302 results on '"Iglesias N"'
Search Results
2. Implementation experience of a guideline on fall prevention in Centres Committed to Excellence in Care®
- Author
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Moreno-Casbas, T., González-María, E., Albornos-Muñoz, L., Córcoles-Jiménez, M.P., Ruiz-García, M.V., Alonso-Poncelas, E., Acosta-Arrocha, A., Ferreiro-Iglesias, N., Lariz-Murua, A., Arza-Alonso, N., Moreno-Rodrigo, A., Rodríguez-Soberado, M.P., Sánchez-Muñoz, M.T., Prada-Roces, M.T., Martínez-González, M.P., Tiñena-Amorós, M., Fernández-García, S., Morell-Bernadí, A., Tejero-Vidal, L.L., Jaria-Lansac, M., Alcañiz-Mesas, Ana Isabel, García-González, Milagros, Zúñiga-Blanco, Lucía, del Barrio-Pintado, M. Begoña, Íñigo-Cruces, Lidia, Folguera-Arnau, Mercè, Albornos-Muñoz, Laura, and Melián-Correa, Esther
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- 2020
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3. Randomized, double-blind, controlled trial, phase III, to evaluate the use of platelet-rich plasma versus hyaluronic acid in hip coxarthrosis
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Villanova-López, M.M., Núñez-Núñez, M., Fernández-Prieto, D., González-López, C., García-Donaire, J., Pérez-Pérez, A., Sandoval Fernández del Castillo, S., Murillo-Izquierdo, M., Camean-Fernández, M., Gutiérrez-Pizarraya, A., Navas-Iglesias, N., Roca-Ruiz, L.J., Calleja-Hernández, M.Á., and Ballester-Alfaro, J.J.
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- 2020
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4. Ensayo clínico fase III para evaluar la eficacia y seguridad del uso de plasma rico en plaquetas frente a ácido hialurónico en coxartrosis
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Villanova-López, M.M., Núñez-Núñez, M., Fernández-Prieto, D., González-López, C., García-Donaire, J., Pérez-Pérez, A., Sandoval Fernández del Castillo, S., Murillo-Izquierdo, M., Camean-Fernández, M., Gutiérrez-Pizarraya, A., Navas-Iglesias, N., Roca-Ruiz, L.J., Calleja-Hernández, M.Á., and Ballester-Alfaro, J.J.
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- 2020
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5. The assessment of echocardiographic clinical utility
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Benyounes Iglesias, N., primary, Van Der Vynckt, C., additional, Lang, S., additional, Pividori, J., additional, Marie, J., additional, Allaoui, M., additional, Amiel Pizziconi, B., additional, and Tibi, T., additional
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- 2024
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6. Correlation of body composition parameters with disease progression in patients with amyotrophic lateral sclerosis
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Rodriguez, J., primary, Monzón, A., additional, Iglesias, N., additional, Calles, L., additional, Hernando, I., additional, Etxeberria, E., additional, Varona, L., additional, Arosa, V., additional, and Izquierdo, J., additional
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- 2023
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7. Redox Polymers for Drug Delivery
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Romero-Azogil, L., primary, Benito, E., additional, Iglesias, N., additional, Galbis, E., additional, de-Paz, M.-V., additional, and García-Martín, M.-G., additional
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- 2020
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8. Structural and magnetic properties of hexagonal Fe3Sn prepared by non-equilibrium techniques
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Echevarria-Bonet, C., Iglesias, N., Garitaonandia, J.S., Salazar, D., Hadjipanayis, G.C., and Barandiaran, J.M.
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- 2018
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9. Characterization of the Population Structure of a Grapefruit Isolate of Citrus tristeza virus (CTV) Selected for Pre-immunization Assays in Argentina
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Iglesias, N. G., Marengo, J., Reiquelme, K., Costa, N., Plata, M. I., and Semorile, L.
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- 2005
10. Genetic Structure of Citrus tristeza virus (CTV) Populations from Field Argentinian Grapefruit Isolates
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Iglesias, N. G., Riquelme, K., Marengo, J., Costa, N., Plata, M. I., and Semorile, L.
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- 2005
11. Citokeratin expresión in gut tissues from Holstein cows with distinct histopathological forms of paratuberculosis
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Balseiro Morales, Ana María [0000-0002-5121-7264], Casais-Goyos, R., Iglesias, T., Navarro León, A.I., Alonso-Hearn, M., Blanco-Vázquez, C., Canive, M., Muñoz, M., Balseiro, Ana, Badía-Bringué, G., Iglesias, N., Balseiro Morales, Ana María [0000-0002-5121-7264], Casais-Goyos, R., Iglesias, T., Navarro León, A.I., Alonso-Hearn, M., Blanco-Vázquez, C., Canive, M., Muñoz, M., Balseiro, Ana, Badía-Bringué, G., and Iglesias, N.
- Published
- 2023
12. Biomarker Discovery using proteomic serum profiling of different pathological forms of bovine paratuberculosis
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Balseiro Morales, Ana María [0000-0002-5121-7264], Navarro León, A.I., Ciordia, S., Muñoz Llamosas, M., Casais, R., Balseiro, Ana, Milhano, F.R., Iglesias, N., Corrales, F.J., Iglesias, T., Blanco-Vázquez, C., Balseiro Morales, Ana María [0000-0002-5121-7264], Navarro León, A.I., Ciordia, S., Muñoz Llamosas, M., Casais, R., Balseiro, Ana, Milhano, F.R., Iglesias, N., Corrales, F.J., Iglesias, T., and Blanco-Vázquez, C.
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- 2023
13. Impacto de la COVID-19 en la salud del paciente poscrítico
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Pinedo Otaola, S., primary, Sanmartín Cuevas, V., additional, Fernández Fernández de Leceta, Z., additional, Pérez Iglesias, N., additional, López De Munain Berganzo, A., additional, Azkuenaga Fernández, M., additional, Pérez Iriondo, A., additional, and Aramburu Ojenbarrena, A., additional
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- 2023
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14. How to perform magnetic resonance imaging in patients with pacemakers or implantable cardioverter defibrillators?
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Tibi, T., primary, Benyounes Iglesias, N., additional, and Van Der Vynckt, C., additional
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- 2023
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15. Oral anticoagulation in patients with atrial fibrillation and medical non-neoplastic disease in a terminal stage
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Díez-Manglano, Jesús, Bernabeu-Wittel, Máximo, Murcia-Zaragoza, José, Escolano-Fernández, Belén, Jarava-Rol, Guadalupe, Hernández-Quiles, Carlos, Oliver, Miguel, Sanz-Baena, Susana, Bernabeu-Wittel, M., Ollero-Baturone, M., Hernández Quiles, C., Moreno-Gaviño, L., Galindo-Ocaña, J., Nieto Martín, D., Praena Segovia, J., Ramírez-Duque, N., Mendoza Giraldo, D., de la Higuera, L., Rincón Gómez, M., García Gutiérrez, M., Fernández, A., Murcia-Zaragoza, J., Escolano Fernández, B., Jarava Rol, G., Maiz-Jiménez, M., Ruiz-Cantero, A., Oliver, M., Díez-Manglano, J., Sanz Baena, S., Barón-Franco, B., Ramos-Cantos, C., Pérez Belmonte, L. M., Loring, M., Sanromán y Terán, C., Macías Mir, P., Camacho González, D., García Ordóñez, M. A., Mora-Rufete, A., Fernández-Moyano, A., Cassani Garza, M., Alemán, A., Sánchez López, P., Díez, F., López-Sáez, J. B., Bayón Sayago, M., Retamar, P.., Masanés, F., López Soto, A., Ternavasio, G., Gómez Lesmes, S., Novo Valeiro, I., Llorente Cancho, H., Polvorosa, M., Alvela, L., Castro Iglesias, N., Fuertes-Martín, A., González-Ruano, P., García García, J. A., Castillo Rubio, R., Serrano Villar, S., Soria-López, M. A., González Gisbert, B., Joya, L., Urrutia de Diego, A., González Escoda, E., Pérez Gutiérrez, M. P., Machín-Lázaro, J. M., Navarro Hidalgo, D., Díez, L., Muniesa, M., Martínez Velasco, C., Zubiaga, M., Feliu-Mazaria, L., Tolchinski, G., Riera Hortelano, R., Giner, P., Fernández-Miera, M. F., Martín Pérez, A., Formiga, F., Cuervo, M. A., and On behalf of the researchers of PALIAR study
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- 2017
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16. Evaluation of the bovine ATP-binding cassette subfamily A member 13 (ABCA13) as a potential biomarker for sensitive detection of animals with focal pathological forms of subclinical paratuberculosis
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Casais, R., Blanco-Vázquez, C., Iglesias, N., Vázquez, P., Juste, R.A., Garrido, J. M., Balseiro, Ana, Canive, M., Amado, J., Queipo, M.A., Iglesias, T., Alonso-Hearn, M., and Balseiro Morales, Ana María
- Abstract
Trabajo presentado al: ICP 15th International Association for Paratuberculous, Dublín, 12-16 Junio. 2022.
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- 2022
17. Child psychiatric emergency visits during the COVID-19 pandemic
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Andreo Jover, J., primary, Hernandez Calle, D., additional, Curto-Ramos, J., additional, Vicente Valor, L., additional, García Martínez, D., additional, Juárez, G., additional, Alcamí, M., additional, Ortiz, A., additional, Iglesias, N., additional, Bravo-Ortiz, M.F., additional, Martinez-Ales, G., additional, and Rodríguez-Vega, B., additional
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- 2022
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18. Evaluation of diagnostic performance of two M. bovis-specific antibody ELISA tests in rabbits
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Juste, R.A., Sevilla, I., Garrido, J.M., Venteo, A., Domínguez, M., Blanco-Vázquez, C., Iglesias, N., Balseiro, Ana, Casais, R., Juste, R.A., Sevilla, I., Garrido, J.M., Venteo, A., Domínguez, M., Blanco-Vázquez, C., Iglesias, N., Balseiro, Ana, and Casais, R.
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- 2022
19. Evaluation of the bovine ATP-binding cassette subfamily A member 13 (ABCA13) as a potential biomarker for sensitive detection of animals with focal pathological forms of subclinical paratuberculosis
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Balseiro Morales, Ana María [0000-0002-5121-7264], Casais, R., Blanco-Vázquez, C., Iglesias, N., Vázquez, P., Juste, R.A., Garrido, J. M., Balseiro, Ana, Canive, M., Amado, J., Queipo, M.A., Iglesias, T., Alonso-Hearn, M., Balseiro Morales, Ana María [0000-0002-5121-7264], Casais, R., Blanco-Vázquez, C., Iglesias, N., Vázquez, P., Juste, R.A., Garrido, J. M., Balseiro, Ana, Canive, M., Amado, J., Queipo, M.A., Iglesias, T., and Alonso-Hearn, M.
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- 2022
20. Proteomic analysis of sera from Holstein Friesian cows with different pathological forms of bovine paratuberculosis (PTB)
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Balseiro Morales, Ana María [0000-0002-5121-7264], Navarro León, A.I., Muñoz, M., Iglesias, N., Blanco Vázquez, Cristina, Balseiro, Ana, Corrales, Fernando J., Ciordia, S., Milhano, Fátima, Casais, R., Balseiro Morales, Ana María [0000-0002-5121-7264], Navarro León, A.I., Muñoz, M., Iglesias, N., Blanco Vázquez, Cristina, Balseiro, Ana, Corrales, Fernando J., Ciordia, S., Milhano, Fátima, and Casais, R.
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- 2022
21. Use of ATP-Binding cassette Subfamily A Member 13 (ABCA13) for sensitive detection of focal pathological forms of subclinical bovine paratuberculosis
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Ministerio de Ciencia e Innovación (España), European Commission, Principado de Asturias, CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Balseiro Morales, Ana María [0000-0002-5121-7264], Blanco-Vázquez, C., Alonso Hearn, M., Iglesias, N., Vázquez, P., Juste, Ramón A., Garrido, J. M., Balseiro, Ana, Canive, M., Amado, J., Queipo, Manuel A., Iglesias, T., Casais, R., Ministerio de Ciencia e Innovación (España), European Commission, Principado de Asturias, CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Balseiro Morales, Ana María [0000-0002-5121-7264], Blanco-Vázquez, C., Alonso Hearn, M., Iglesias, N., Vázquez, P., Juste, Ramón A., Garrido, J. M., Balseiro, Ana, Canive, M., Amado, J., Queipo, Manuel A., Iglesias, T., and Casais, R.
- Abstract
Bovine paratuberculosis (PTB) is a chronic enteritis caused by Mycobacterium avium subspecies paratuberculosis (Map) that causes a heavy economic impact worldwide. Map infected animals can remain asymptomatic for years while transmitting the mycobacteria to other members of the herd. Therefore, accurate detection of subclinically infected animals is crucial for disease control. In a previous RNA-Seq study, we identified several mRNAs that were overexpressed in whole blood of cows with different PTB-associated histological lesions compared with control animals without detected lesions. The proteins encoded by two of these mRNAs, ATP binding cassette subfamily A member 13 (ABCA13) and Matrix Metallopeptidase 8 (MMP8) were significantly overexpressed in whole blood of animals with focal histological lesions, the most frequent pathological form in the subclinical stages of the disease. In the current study, the potential of sensitive early diagnostic tools of commercial ELISAs, based on the detection of these two biomarkers, was evaluated in serum samples of 704 Holstein Friesian cows (566 infected animals and 138 control animals from PTB-free farms). For this evaluation, infected animals were classified into three groups, according to the type of histological lesions present in their gut tissues: focal (n = 447), multifocal (n = 59), and diffuse (n = 60). The ELISA based on the detection of ABCA13 was successfully validated showing good discriminatory power between animals with focal lesions and control animals (sensitivity 82.99% and specificity 80.43%). Conversely, the MMP8-based ELISA showed a poor discriminatory power between the different histological groups and non-infected controls. The ABCA13-based ELISA showed a higher diagnostic value (0.822) than the IDEXX ELISA (0.517), the fecal bacterial isolation (0.523) and the real-time PCR (0.531) for the detection of animals with focal lesions. Overall, our results indicate that this ABCA13 ELISA greatly improves the
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- 2022
22. Temporal resource partitioning mediates vertebrate coexistence at carcasses: The role of competitive and facilitative interactions
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Junta de Comunidades de Castilla-La Mancha, Fundação para a Ciência e a Tecnologia (Portugal), Olea, Pedro P., Iglesias, N., Mateo-Tomás, Patricia, Junta de Comunidades de Castilla-La Mancha, Fundação para a Ciência e a Tecnologia (Portugal), Olea, Pedro P., Iglesias, N., and Mateo-Tomás, Patricia
- Abstract
Unravelling how biodiversity is maintained despite species competition for shared resources has been a central question in community ecology, and is gaining relevance amidst the current biodiversity crisis. Yet, we have still a poor understanding of the mechanisms that regulate species coexistence and shape the structure of assemblages in highly competitive environments such as carrion pulsed resources. Here, we study how large vertebrates coexist in scavenger assemblages by adapting their diel activity at large ungulate carcasses in NW Spain. We used camera traps to record vertebrate scavengers consuming 34 carcasses of livestock and hunted wild ungulates, which allowed us to assess also differences regarding carcass origin. To evaluate temporal resource partition among species, we estimated the overlap of diel activity patterns and the mean times of each scavenger at carcasses. We recorded 16 species of scavengers, 7 mammals and 9 birds, and found similar richness at both types of carcasses. Birds and mammals showed contrasting diel activity patterns, with birds using carcasses during daytime (mean= 11:38 h) and mammals mostly at night (23:09 h). The unimodal activity patterns of scavengers showed asynchronous peaks among species. Subordinate species modified their activity patterns at carcasses used by apex species to reduce temporal overlap. Also, diel activity patterns of vultures closely followed those of corvids, suggesting facilitation processes in which corvids would enhance carcass detection by vultures. Two mammal species (12.5%) increased nocturnality at carcasses of hunted ungulates, which could be a response to human disturbance. Our results suggest that both temporal segregation and coupling mediate the coexistence of large vertebrates at carcasses. These mechanisms might lead to richer scavenger assemblages and thereby more efficient ones in driving critical ecosystem functions related to carrion consumption, such as energy and nutrient recycling and
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- 2022
23. Double immunofluorescence staining of whole-mount small intestinal mucosa simples as a tool for characterization on three-dimensional paratuberculosis granulomas
- Author
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Principado de Asturias, European Commission, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Balseiro Morales, Ana María [0000-0002-5121-7264], Casais, R., Guervos, M.A., Navarro León, A.I., Blanco-Vázquez, C., Iglesias, N., Balseiro, Ana, Muñoz, M., Principado de Asturias, European Commission, Ministerio de Ciencia e Innovación (España), Agencia Estatal de Investigación (España), Balseiro Morales, Ana María [0000-0002-5121-7264], Casais, R., Guervos, M.A., Navarro León, A.I., Blanco-Vázquez, C., Iglesias, N., Balseiro, Ana, and Muñoz, M.
- Abstract
Bovine paratuberculosis (PTB) is a chronic granulomatous enteritis, caused by Mycobacterium avium subsp. paratuberculosis (Map). The progression of PTB from subclinical to the clinical stage of the disease is determined locally at the level of the granuloma, a host defence hallmark against mycobacterial infection. Therefore, in- depth characterization of distinct cell populations controlling granuloma formation is critical to understanding PTB progression. Confocal laser scanning microscopy (CLSM) has been extensively used to visualize two or more proteins of interest concomitantly within a variety of cellular structures. As such, it is an invaluable tool for the correct identification and characterization of different cell populations. In this study, a novel approach, CLSM of whole-mount small intestinal mucosa samples, is used to characterize three-dimensional (3-D) paratuberculosis granulomas and epithelioid macrophages. Detailed optimized procedures to perform CLSM in whole mount small intestinal mucosa samples and also in formalin fixed paraffin embedded (FFPE) intestinal tissue sections of Holstein Friesian cows presenting different types of PTB-associated histological lesions are described.
- Published
- 2022
24. Introduction of standardised parenteral nutrition for paediatric and neonatal patients using multichamber bags - an impact assessment on aseptic services capacity
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Zeraschi, S.L., primary, Iglesias, N., additional, Mak, K., additional, Dawson, E., additional, Lowey, A.R., additional, Forster, C.G., additional, and Ward, E., additional
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- 2022
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25. Proteomic analysis of sera from Holstein Friesian cows with different pathological forms of bovine paratuberculosis (PTB)
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Navarro León, A.I., Muñoz, M., Iglesias, N., Blanco Vázquez, C., Balseiro, Ana, Corrales, F.J., Ciordia, S., Milhano, F.R., and Casais, R.
- Abstract
Trabajo presentado al: ICP 15th International Association for Paratuberculous, Dublín, 12 -16 June. 2022.
- Published
- 2022
26. Zinc recovery from an effluent using Ionquest 290: From laboratory scale to pilot plant
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Avila, M., Grinbaum, B., Carranza, F., Mazuelos, A., Romero, R., Iglesias, N., Lozano, J.L., Perez, G., and Valiente, M.
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- 2011
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27. ¿POR QUÉ LAS MUJERES NO SE TOMAN EL PAPANICOLAU?: BARRERAS PERCIBIDAS POR UN GRUPO DE MUJERES INGRESADAS AL PROGRAMA DE CÁNCER CERVICOUTERINO AUGE
- Author
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María Teresa Urrutia S, Lauren Poupin B, Ximena Concha P, Daisy Viñales A, Cecilia Iglesias N, and Viviana Reyes I
- Subjects
Papanicolau ,cáncer cérvicouterino ,programas de salud ,barreras ,Papanicolau test ,cervical cancer ,health programs ,barriers ,Gynecology and obstetrics ,RG1-991 - Abstract
Antecedentes: A comienzos de los 70, se introdujo en Chile el examen de citología cervical para la pesquisa precoz de cáncer cérvico uterino. La adherencia a este examen ha demostrado su utilidad para la pesquisa oportuna de la patología y para la disminución de la mortalidad. Objetivo: Examinar las percepciones que tiene un grupo de mujeres chilenas con lesiones preinvasoras de cuello uterino, sobre el Papanicolau. Método: Estudio descriptivo, cualitativo, transversal. Se entrevista a un grupo de 237 mujeres ingresadas al programa AUGE del Servicio de Salud Metropolitano Sur-Oriente, Santiago, Chile. Resultados: Las principales razones para no hacerse el Papanicolau y no acudir a buscar el resultado fueron: la falta de preocupación; los problemas relacionados al procedimiento como miedo, vergüenza, incomodidad y falta de tiempo; y la falta de conocimiento. Conclusión: Todas las razones dadas por las mujeres chilenas en este estudio, han sido descritas en la literatura internacional. Los profesionales de la salud están en situación de cambiar la perspectiva que las mujeres tienen y por lo tanto para mejorar la educación y la práctica del screening en las mujeres. Resultados de este estudio pueden servir de guía para desarrollar programas educativos y posteriormente ser aplicados en la práctica clínica.Background: At the beginning of the 70s, the exam of cervical cytology was introduced in Chile. The ad-herence to this exam has demonstrated its utility for the opportune search of the pathology and mortality decrease. Objective: To examine perceptions about the Papanicolau (PAP) test from the perspectives of Chilean women with premalignant lesions. Method: Descriptive, qualitative, and cross-sectional study in a group of 237 women from AUGE program in the Southeast Metropolitan Public Health Service, Santiago, Chile. Results: The principal reasons for not having had a PAP test were procrastination; the problems related to the PAP test procedure like fear, embarrassment, discomfort, and lack of time; and lack of knowledge. Conclusión: All the reasons given by the Chilean women in this study have been described in the international literature. Health professionals are in a position to change the perspective that the women have, and therefore for increasing the education and cervical cáncer screening for women. Results of this study can serve as a guide for education programs and can be applied in clinical practice.
- Published
- 2008
28. Operational pH in packed-bed reactors for ferrous ion bio-oxidation
- Author
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Mazuelos, A., Carranza, F., Romero, R., Iglesias, N., and Villalobo, E.
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- 2010
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29. Valoración de la Atención Continuada en un Centro de Salud Rural de la Comarca de la Vera en la provincia de Cáceres
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Mateos Iglesias, N., Tobajas Belvís, L., Tobajas Belvís, J., Tobajas Pizarro, L., and Fernández del Valle, P.
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- 2010
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30. Biorecovery of copper from converter slags: Slags characterization and exploratory ferric leaching tests
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Carranza, F., Romero, R., Mazuelos, A., Iglesias, N., and Forcat, O.
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- 2009
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31. Molecular virology of dengue virus.
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Iglesias, N. G., primary, Byk, L. A., additional, and Gamarnik, A. V., additional
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- 2014
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32. Control de la paratuberculosis bovina: identificación y validación de biomarcadores de detección precoz de la enfermedad
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Casais, R., Blanco-Vázquez, C., Iglesias, N., Balseiro, Ana, Vicente, F., Amado, J., Canive, M., Juste, R., Alonso-Hearn, M., CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Balseiro Morales, Ana María, and Balseiro Morales, Ana María [0000-0002-5121-7264]
- Abstract
6 páginas, 3 tablas, 3 figuras., Las enfermedades son responsables del 20% de las pérdidas de la producción animal y constituyen una de las barreras al comercio de animales vivos y alimentos de origen animal. En este contexto, cabe destacar la importancia estratégica de la sanidad animal, ya que garantiza la salud y el bienestar animal, la salud pública, la seguridad alimentaria, la producción sostenible de alimentos, la conservación del medio ambiente y la sostenibilidad y competitividad de la producción ganadera y la economía rural. (Rodríguez García y col., 2014)., Este estudio ha sido financiado por el Instituto Nacional de Investigaciones Agrarias (INIA RTA-2014-00009-C02), el Ministerio de Ciencia, Innovación y Universidades (MICINN RTI2018-094192-R-C22), Fondos Europeos para el Desarrollo Regional (FEDER) y fondos regionales PCTI 2018–2020 (GRUPIN: IDI2018-000237). Agradecemos al INIA la financiación de los contratos pre-doctorales de formación de Cristina Blanco Vázquez y María Canive.
- Published
- 2021
33. Control de la paratuberculosis bovina: nuevos métodos de diagnóstico basados en la detección de biomarcadores bovinos
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CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Balseiro Morales, Ana María [0000-0002-5121-7264], Casais, R, Blanco-Vázquez, C., Iglesias, N., Balseiro, Ana, Vicente, F., Amado, J., Canive, M., Juste, R., Alonso Hearn, M., CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Balseiro Morales, Ana María [0000-0002-5121-7264], Casais, R, Blanco-Vázquez, C., Iglesias, N., Balseiro, Ana, Vicente, F., Amado, J., Canive, M., Juste, R., and Alonso Hearn, M.
- Published
- 2021
34. Control de la paratuberculosis bovina: identificación y validación de biomarcadores de detección precoz de la enfermedad
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CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Balseiro Morales, Ana María [0000-0002-5121-7264], Casais, R., Blanco-Vázquez, C., Iglesias, N., Balseiro, Ana, Vicente, F., Amado, J., Canive, M., Juste, R., Alonso-Hearn, M., CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Balseiro Morales, Ana María [0000-0002-5121-7264], Casais, R., Blanco-Vázquez, C., Iglesias, N., Balseiro, Ana, Vicente, F., Amado, J., Canive, M., Juste, R., and Alonso-Hearn, M.
- Abstract
Las enfermedades son responsables del 20% de las pérdidas de la producción animal y constituyen una de las barreras al comercio de animales vivos y alimentos de origen animal. En este contexto, cabe destacar la importancia estratégica de la sanidad animal, ya que garantiza la salud y el bienestar animal, la salud pública, la seguridad alimentaria, la producción sostenible de alimentos, la conservación del medio ambiente y la sostenibilidad y competitividad de la producción ganadera y la economía rural. (Rodríguez García y col., 2014).
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- 2021
35. Biomarcadores de detección precoz de la paratuberculosis
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CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Balseiro Morales, Ana María [0000-0002-5121-7264], Casais, R., Blanco Vázquez, Cristina, Iglesias, N., Balseiro, Ana, Vicente, F., Amado, J., Canive, M., Juste, R., Alonso Hearn, M., CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Balseiro Morales, Ana María [0000-0002-5121-7264], Casais, R., Blanco Vázquez, Cristina, Iglesias, N., Balseiro, Ana, Vicente, F., Amado, J., Canive, M., Juste, R., and Alonso Hearn, M.
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- 2021
36. Bovine intelectin 2 expression as a biomarker of paratuberculosis disease progression
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CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Balseiro Morales, Ana María [0000-0002-5121-7264], Blanco-Vázquez, C., Balseiro, Ana, Alonso Hearn, M., Juste, Ramón A., Iglesias, N., Canive, M., Casais, R., CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Balseiro Morales, Ana María [0000-0002-5121-7264], Blanco-Vázquez, C., Balseiro, Ana, Alonso Hearn, M., Juste, Ramón A., Iglesias, N., Canive, M., and Casais, R.
- Abstract
Paratuberculosis (PTB), a chronic granulomatous enteritis caused by Mycobacterium avium subsp. paratuberculosis (MAP), is responsible for important economic losses in the dairy industry. Our previous RNA-sequencing (RNA-Seq) analysis showed that bovine intelectin 2 (ITLN2) precursor gene was overexpressed in ileocecal valve (ICV) samples of animals with focal (log2 fold-change = 10.6) and diffuse (log2 fold-change = 6.8) PTB-associated lesions compared to animals without lesions. This study analyzes the potential use of ITLN2, a protein that has been described as fundamental in the innate immune response to infections, as a biomarker of MAP infection. The presence of ITLN2 was investigated by quantitative immunohistochemical analysis of ICV samples of 20 Holstein Friesian cows showing focal (n = 5), multifocal (n = 5), diffuse (n = 5) and no histological lesions (n = 5). Significant differences were observed in the mean number of ITLN2 immunostained goblet and Paneth cells between the three histopathological types and the control. The number of immunolabelled cells was higher in the focal histopathological type (116.9 ± 113.9) followed by the multifocal (108.7 ± 140.5), diffuse (76.5 ± 97.8) and control types (41.0 ± 81.3). These results validate ITLN2 as a post-mortem biomarker of disease progression.
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- 2021
37. Combined therapeutic effect of a monoclonal anti-idiotype tumor vaccine against NeuGc-containing gangliosides with chemotherapy in a breast carcinoma model
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Fuentes, D., Avellanet, J., Garcia, A., Iglesias, N., Gabri, M. R., Alonso, D. F., Vazquez, A. M., Perez, R., and Montero, E.
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- 2010
- Full Text
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38. Chromium speciation in Zr-based Metal-Organic Frameworks for environmental remediation
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Saiz, G. Paula, Iglesias, N, Gonzalez-Navarrete, B, Rosales, M, Reizabal-Para, A, Fidalgo-Marijuan, Arkaitz, Larrea, Edurne S., Lopes, C, Lezama, L, García, A, Lanceros-Mendez, S., Arriortua, María Isabel, and Fernandez de Luis, Roberto
- Subjects
Water pollution ,TheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITY ,Photocatalysis ,Metal Organic Frameworks ,Chromium reduction - Abstract
Acute CrVI water pollution due to anthropogenic activities is an increasing worldwide concern. The high toxicity and mobility of CrVI makes necessary to develop dual adsorbent/ion-reductive materials able to capture CrVI and transform it efficiently to less hazardous CrIII. The accurate description of the chromium speciation at the adsorbent/ion-reductive matrix is key to assess whether CrVI is completely reduced to CrIII or if an incomplete transformation leds to the stabilization of highly reactive CrV transient species within the material. With this goal in mind, a dual ultraviolet visible and electron paramagnetic spectroscopy approach has been applied to determine the chromium speciation within Zr-based metal-organic frameworks (MOFs). Our findings point out that the generation of defect positions at Zr-MOFs boost CrVI adsorption, whilst the presence of reductive groups at the organic linkers play a key role to stabilize CrIII as isolated and/or clustered ions.
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- 2020
39. Detection of latent forms of Mycobacterium avium subsp. paratuberculosis infection using host biomarker-based ELISAs greatly improves paratuberculosis diagnostic sensitivity
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CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Principado de Asturias, Blanco-Vázquez, C., Alonso-Hearn, M., Juste, Ramón A., Canive, M., Iglesias Navarro, Tania, Iglesias, N., Amado, J., Vicente, F., Balseiro, Ana, Casais, R., CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Principado de Asturias, Blanco-Vázquez, C., Alonso-Hearn, M., Juste, Ramón A., Canive, M., Iglesias Navarro, Tania, Iglesias, N., Amado, J., Vicente, F., Balseiro, Ana, and Casais, R.
- Abstract
Bovine paratuberculosis (PTB) is a chronic granulomatous enteritis, caused by Mycobacterium avium subsp. paratuberculosis (MAP), responsible for important economic losses in the dairy industry. Current diagnostic methods have low sensitivities for detection of latent forms of MAP infection, defined by focal granulomatous lesions and scarce humoral response or MAP presence. In contrast, patent infections correspond to multifocal and diffuse types of enteritis where there is increased antibody production, and substantial mycobacterial load. Our previous RNA-Seq analysis allowed the selection of five candidate biomarkers overexpressed in peripheral blood of MAP infected Holstein cows with focal (ABCA13 and MMP8) and diffuse (FAM84A, SPARC and DES) lesions vs. control animals with no detectable PTB-associated lesions in intestine and regional lymph nodes. The aim of the current study was to assess the PTB diagnostic potential of commercial ELISAs designed for the specific detection of these biomarkers. The ability of these ELISAs to identify animals with latent and/or patent forms of MAP infection was investigated using serum from naturally infected cattle (n = 88) and non-infected control animals (n = 67). ROC analysis revealed that the ABCA13-based ELISA showed the highest diagnostic accuracy for the detection of infected animals with focal lesions (AUC 0.837, sensitivity 79.25% and specificity 88.06%) and with any type of histological lesion (AUC 0.793, sensitivity 69.41% and specificity 86.57%) improving on the diagnostic performance of the popular IDEXX ELISA and other conventional diagnostic methods. SPARC and MMP8 showed the highest diagnostic accuracy for the detection of animals with multifocal (AUC 0.852) and diffuse lesions (AUC 0.831), respectively. In conclusion, our results suggest that quantification of ABCA13, SPARC and MMP8 by ELISA has the potential for implementation as a diagnostic tool to reliably identify MAP infection, greatly improving early dete
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- 2020
40. Application of sugar foam to a pyrite-contaminated soil
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Moraza, C. Jiménez, Iglesias, N., and Palencia, I.
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- 2006
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41. Recycling EAF dust leaching residue to the furnace: A simulation study
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Palencia, I., Romero, R., Iglesias, N., and Carranza, F.
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- 1999
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42. Experiencia en la implantación de la Guía de prevención de caídas en Centros Comprometidos con la Excelencia en Cuidados®
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Alcañiz-Mesas, Ana Isabel, primary, García-González, Milagros, additional, Zúñiga-Blanco, Lucía, additional, del Barrio-Pintado, M. Begoña, additional, Íñigo-Cruces, Lidia, additional, Folguera-Arnau, Mercè, additional, Albornos-Muñoz, Laura, additional, Melián-Correa, Esther, additional, Moreno-Casbas, T., additional, González-María, E., additional, Albornos-Muñoz, L., additional, Córcoles-Jiménez, M.P., additional, Ruiz-García, M.V., additional, Alonso-Poncelas, E., additional, Acosta-Arrocha, A., additional, Ferreiro-Iglesias, N., additional, Lariz-Murua, A., additional, Arza-Alonso, N., additional, Moreno-Rodrigo, A., additional, Rodríguez-Soberado, M.P., additional, Sánchez-Muñoz, M.T., additional, Prada-Roces, M.T., additional, Martínez-González, M.P., additional, Tiñena-Amorós, M., additional, Fernández-García, S., additional, Morell-Bernadí, A., additional, Tejero-Vidal, L.L., additional, and Jaria-Lansac, M., additional
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- 2020
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43. Implementation experience of a guideline on fall prevention in Centres Committed to Excellence in Care®
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Alcañiz-Mesas, Ana Isabel, primary, García-González, Milagros, additional, Zúñiga-Blanco, Lucía, additional, del Barrio-Pintado, M. Begoña, additional, Íñigo-Cruces, Lidia, additional, Folguera-Arnau, Mercè, additional, Albornos-Muñoz, Laura, additional, Melián-Correa, Esther, additional, Moreno-Casbas, T., additional, González-María, E., additional, Albornos-Muñoz, L., additional, Córcoles-Jiménez, M.P., additional, Ruiz-García, M.V., additional, Alonso-Poncelas, E., additional, Acosta-Arrocha, A., additional, Ferreiro-Iglesias, N., additional, Lariz-Murua, A., additional, Arza-Alonso, N., additional, Moreno-Rodrigo, A., additional, Rodríguez-Soberado, M.P., additional, Sánchez-Muñoz, M.T., additional, Prada-Roces, M.T., additional, Martínez-González, M.P., additional, Tiñena-Amorós, M., additional, Fernández-García, S., additional, Morell-Bernadí, A., additional, Tejero-Vidal, L.L., additional, and Jaria-Lansac, M., additional
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- 2020
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44. 3PC-045 Impact of the preparation of a clinical solution of rituximab 1.0 mg/mL on the particulates (aggregation) measured by dynamic light scattering: sodium chloride and glucose concentration, and agitation effect
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Natalia-Iglesias, N, primary, Hermosilla, J, additional, Exposito, J, additional, Salmerón-Garcia, A, additional, and Cabeza, J, additional
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- 2020
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45. Diagnóstico precoz de la paratuberculosis bovina mediante ELISAs basados en la detección de biomarcadores proteicos
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Blanco-Vázquez, C., Alonso Hearn, M., Juste, R., Balseiro, Ana, Iglesias, N., Copano, F., Amado, J., Canive, M., Casais, R., European Commission, and Ministerio de Ciencia, Innovación y Universidades (España)
- Abstract
Trabajo presentado al: XXIV Simposio de AVEDILA. Pamplona, 7-8 noviembre 2019., Este estudio forma parte del proyecto coordinado “Marcadores Inmunológicos y genéticos asociados a infecciones latentes o patentes causadas por Mycobacterium avium subsp. paratuberculosis” que ha sido financiado por el Instituto Nacional de Investigaciones Agrarias (INIA RTA-2014-00009-C02), el Ministerio de Ciencia, Innovación y Universidades (MICINN RTI2018-094192-R-C22), Fondos Europeos para el Desarrollo Regional (FEDER) y fondos regionales PCTI 2018-2020 (GRUPIN: ID2018-000237).
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- 2019
46. Linagliptin Effects on Heart Failure and Related Outcomes in Individuals With Type 2 Diabetes Mellitus at High Cardiovascular and Renal Risk in CARMELINA
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McGuire D, Alexander J, Johansen O, Perkovic V, Rosenstock J, Cooper M, Wanner C, Kahn S, Toto R, Zinman B, Baanstra D, Pfarr E, Schnaidt S, Meinicke T, George J, von Eynatten M, Marx N, Aizenberg D, Fiorella A, Edgardo N, Belen C, Alonso P, Walter M, Maia K, Guillermo S, Leandro B, Constanza R, Alejandra N, Melina C, Ariel I, Rodrigo C, Alvarez C, Jorge M, Gabriel C, German S, Bartolacci I, Bolobanich G, Tale T, Meritano M, Echeverria M, Gerrini S, Alvarez M, Torrijos N, Berli M, Coggiola J, Castaneda G, Rode R, Milessi R, Roude A, Bono J, Caresani J, Arias V, Westberg J, Allende G, Liberman A, Bordonava A, Almagro S, Gerbaudo C, Schiavi L, Budassi N, Cecilia M, Buncuga M, Carlos S, Osvaldo T, Mercedes S, Calella P, Agustina V, Aljandro M, Alberto D, Fiorella M, Cantero M, Cariganano M, Anadon P, Cartasegna L, Gabriela M, Fernanda A, Alberto R, Chacon C, Jazmin F, Colombo H, Coni E, Mattausch S, Thomsenhall K, della Torre M, Morandini M, Berra F, Margarita H, Commendatore V, Tedesco J, Bolzan P, Cuneo C, Narcisa G, Caputi V, Pablo S, Sandra G, Pacora F, Tinari M, Jure H, Parody M, Toranzo A, Frechtel G, Yohena S, Lovecchio S, Muller C, Martin S, Olivera C, Breyaui M, Bianchi G, Garcia C, Luciana V, Florencia F, Ruben G, Gelersztein E, Rey G, Sanchez C, Fornasari L, Di Pierro L, Giacomi G, Miguel S, Laura T, Gonzalo C, Ramon C, Glenny J, Koretzky M, Porto A, Tiberio O, Ellenberg A, Saurral R, Igarzabal C, Vilamajo O, Matkovich J, de Lapertosa S, Villagra M, Cuzziol G, de la Cruz M, Pinchetti R, Mierez M, Lopez C, Gorosito V, Gabito A, Kleiban A, Grosembacher L, Adrian P, Paula R, Javier G, Kraft F, Andres F, Krynski F, Nicolas P, Marcelo F, Alfredo F, de la Fuente R, Natalia C, Luquez H, Recuero Y, Becchetti N, Ruiz M, Costantino M, Vazquez G, Guzman C, Pelatia P, Maffei L, Sassone S, Yantorno M, Prado G, Khron B, Maldonado N, Gustavo L, Veronica V, Marino J, Elizabeth A, Alejandra C, Oscar R, Azize G, Gallardo M, Escudero M, Vargas E, Ramos H, Lucero C, Najenson M, Crocci I, Chiesa A, Nardone L, Dominguez S, Zanini A, Manghi F, Grossman M, Giudice G, Romeo A, Piskorz D, Miguel C, Susana D, Noeli U, Rosa S, Martin V, Soledad A, Virginia M, Lorena G, Prado A, Veronica L, Eduardo H, Adolfo P, Florencia W, Rista L, Scolari C, Rojas N, Bertolio V, Zarandon R, Jair S, Orlando C, Sanabria H, Ignacio D, Viviana C, Marina R, Sarjanovich R, Scaro G, Huerta C, Mana M, Gutierrez M, Dain A, Gavicola R, Sessa H, Sacripanti J, Felman R, Vilarino P, Sicer M, Lagrutta M, Sala J, Casabella T, Cecilia H, Carlos B, Vines G, Javier R, Vico M, Lanchiotti P, Martella C, Torres L, Villarino A, Molina M, Martinez J, Farias C, Bertola S, Rojas M, Guzman P, Nisi J, Martinez D, Barrionuevo M, Vita N, Lopez A, Vottero E, Giuliano M, Paron L, Vogel D, Mele P, Imposti H, Dominguez A, Zaidman C, Fernando G, Beck M, Beltrame P, Chemello D, Junior R, Abreu A, Fernandes V, Saboia J, Rodrigues L, Carvalho M, Gurgel M, Gadelha D, Ramos C, Borba V, Golbert M, Pitthan M, Golbert L, Valentini R, Canani L, Gross J, Valenti A, Sartori C, Dutra O, Azevedo E, Azevedo A, Vaz R, Vaz H, da Costa F, da Costa L, Panarotto D, Lain F, Camazzola F, Dellomea B, Rech R, Pizzato P, Nunes C, Jaeger C, Silveira D, Wagner L, Machado L, Rea R, de Bem A, Alves J, Jonasson T, Malucelli F, Betti R, Lerario A, Lisboa H, Bem J, Tres G, Tavares C, Nardi A, Pozzatto M, Backes L, Reolao J, Scariot E, Ziguer E, Baldissera D, Griz L, Antunes D, Victor F, Freire K, Barros A, Costi B, Sa M, Carneiro A, Felicio J, Felicio K, Penha P, Ferreira J, Melo F, Alves A, Souza A, Costa L, Pinheiro D, Turatti L, Augusto G, Leanca C, Santomauro A, Forti A, Sena R, Marinho A, Facanha C, de Souza K, de Souza A, de Queiroz W, Leite S, Vieira S, Gubert L, Olsen A, Piazzetta G, Fuck A, Ferreira M, Fortes J, Brandao T, Alves F, Radice E, dos Santos J, de Almeida R, Franco D, Saporito W, Eliaschewitz F, de Siqueira K, Bona R, Genestreti P, de Castro D, Visconti G, Sampaio C, Palhares F, Konigsfeld H, Alves E, Feder C, Leao B, Saraiva J, Rodovalho S, Costa M, Pires N, Figueiredo E, Werner G, Garcia J, de Paiva I, Quirino B, Botelho R, da Silva R, Navarro A, Lourenco C, Pereira A, Arantes F, Boner D, Saad J, Falchetto E, Washizu E, Mandil A, Pimenta N, Tofani F, Fonseca T, Teixeira L, Maia L, Lemos M, Mouco O, Nakazone M, Weiand L, Bohn J, Hissa M, Araripe F, Carvalho F, Cancado G, Wang R, Chacra A, Fusaro A, de Mendonca E, Cercato C, Halpern A, Alves B, Braile M, Sestito R, Mustafa E, Ferreira V, Sbardellini B, de Almeida P, Guimaraes F, Piedade M, Bienert I, Braga J, Daher R, Hirakawa T, Terra E, Farias E, Figueiredo M, Lima L, Moraes K, Avelino I, Flato U, Plavnik F, Portes E, Moreira M, Vendramini M, Veloso R, Padilha M, Rodrigues A, Adam R, Santos S, Sayeg N, Guerrero D, Madeira M, Siqueira J, Pinheiro R, Villacorta A, Mellazi A, Braga T, Kaiser S, Paolino B, Lefterov I, Marinchev A, Angelova S, Klyuchkova N, Lybomirova Z, Kerekovski Y, Kuneva T, Penkova D, Levterov G, Videnova E, Georgieva P, Shinkov A, Borissova A, Vlahov J, Dakovska-Dekova L, Lucheva M, Luchev P, Temelkova M, Borisova K, Tsenov S, Andreeva V, Margaritov V, Arasheva G, Lozanov L, Borisov R, Gorcheva D, Henein S, Whatley S, Boutros M, Kalyniuk N, Berlingieri J, Nisker W, Hoag G, Hepburn D, Harvey M, Manjoo P, Yale J, Sherman M, Tsoukas M, Rehman W, Mason M, Santerre M, De Kock J, Barkhuizen F, Rooke C, Gill C, Kooy J, Burgoyne G, de Kock J, Degen G, Hockman L, Invik R, Roberts P, Ward K, Alasaad H, Susan A, Davies V, Gupta N, Milhalidis J, Grossman L, Agawal N, Yared Z, Rwaheed, Nouhad S, Nahla A, Khandwala H, Warwick A, Wadehra D, Manan A, Vecchiarelli J, Aslam N, Ferrao A, St-Maurice F, Collette R, Davey B, Nawaz S, Coutu B, Costi P, Greiss I, Mansour F, Raymond J, St-Phard W, Nadra I, Della Siega A, Barahona L, Klinke P, Contractor H, Fryer M, Chandra N, Conti B, Telzer L, Sorensen S, Lounsbury N, Martin E, Mitchell L, Pelzer E, Nelson S, Jones M, Cox J, Luco G, Trhoughton T, Labonte R, Chouinard G, Frechette A, Rheaume M, Cusson J, Faucher J, Dery V, Kelly A, Miranda B, Al-Kayssi N, Malette P, Rheault P, Fredette P, Dumas R, Palardy J, Belanger A, Boucher P, Doyon B, Charbonneau J, Bailey G, Odendaal M, Stephan K, Badenhorst J, Knight D, Thurgood A, Johnston M, Cooper-Rosen E, Jagger R, Green M, Weisnagel S, Gangloff A, Bergeron J, Pesant Y, Chevalier P, Woo V, Hurd C, Ruckert G, Lira J, Navarro G, Venegas M, Gonzalez P, Montecinos H, Vidal G, Fernandez M, Varas J, Fernandez C, Aguilar J, Marin R, Kindel C, Yovaniniz P, Gherman O, Aravena M, Carvajal J, Macias E, Corrado P, Lazcano M, Garrido B, Charme G, Carrasco J, Vignolo P, Saavedra S, Gajardo V, Saavedra C, Santamaria D, del Castillo B, Balda I, Zurvarra V, Fu G, Jiang D, Huang H, Wang M, Song J, Lu W, Lin Y, Lu Z, Shi Y, Zhong M, Zhao X, Chen D, Zhang G, He Y, Shi P, Chu K, Gao Q, Deng W, Zhang J, Zhang Y, Chen H, Liu E, Xie Y, Lin R, Tan W, Yuan Z, Wang Y, Ren J, Yu H, Luo M, Ma W, Shi W, Xu H, Xu M, Liu G, Dong Y, Bai B, Guo R, Liu X, Gao Y, Li S, Xu X, Liu P, Dong X, Wang S, Fu F, Jiang Q, Meng C, Yin X, Lu Y, Cui Y, Su G, Miao W, Wei F, Zhao Q, Li Z, Gao X, Lozno H, Prada W, Figueroa W, Ordonez A, Quintero E, Vallejo G, Contreras C, Escobar J, Alvaran J, Ortiz L, Marin M, Montoya C, Mendoza J, Manjarres J, Navarro B, Martinez G, Bonfanti A, Perci X, de la Hoz L, Arroyo J, Rendon C, Lopez J, Escobar N, Franco J, Lozano M, Zapata C, Ibarra L, Barrero A, Sarmiento A, Lozada H, Olitte M, Florez L, Munoz C, Quintero G, Correa G, Ruiz S, Dorado A, Causa A, Palma E, Morales A, Arteaga J, Beltran J, Granados M, Rubio A, Dada F, Bueno W, Rivera R, Corredor K, Romero V, Accini F, Palmera J, Ruiz G, Ortega M, Sanchez A, Lora Y, Cano J, Duque S, Thiriez S, Castano M, Giraldo P, Boljkovac Z, Grcic I, Balen M, Zukanovic S, Jeric M, Dvorscak D, Car S, Knezevic A, Herceg D, Franov B, Miskovic V, Bakula M, Hadak A, Superba M, Rubes J, Gornik I, Hamzic J, Ballek L, Sedlackova L, Hejlova J, Galatikova D, Huskova A, Zak P, Flekac M, Mraz M, Potuznik P, Palova S, Novak P, Okenka L, Matuska J, Rohac F, Vondrak K, Reichert P, Shamasna A, Skopek J, Lejskova M, Jiruska M, Lang P, Podoubsky R, Svobodova J, Cifkova R, Jozifova M, Krajcoviechova A, Wolfhart P, Sulc P, Silhova E, Cechakova M, Machova V, Balkova J, Peterka M, Votocek S, Prosecky R, Valis M, Barton P, Tomek J, Pumprla J, Axmannova M, Vitaskova R, Sincl F, Horanska P, Richter B, Malicherova E, Roderova E, Jenickova P, Winkelmann B, Finger C, Klausmann G, Milek K, Schwabe M, Weiss N, Mahlmann A, Werth S, Schmidt C, Schoell I, London M, Steidl E, Orban K, Taeschner H, Bonigut S, Schiefke I, Schwittay A, Kornmann O, Eich A, Franke S, Kis J, Szobota E, Danos P, Beke E, Grosz A, Csecsei G, Ferenczy J, Filo A, Ferencz I, Mihaly E, Baranyi T, Revesz K, Schlezak J, Harcsa E, Dombroczki Z, Kocsis I, Juhasz E, Literati-Nagy B, Kulcsar E, Bezzeg K, Kemeny V, Peterfai E, Buday B, Keltai K, Balo T, Somogyi A, Nagy G, Oroszlan T, Bagosi Z, Bujtor Z, Tabak A, Ferencz V, Domjan B, Tanczer T, Palinkas A, Karolyi H, Kovacs K, Csaszar I, Palhegyi E, Engelhalter G, Horthy R, Vanko E, Szabo G, Sipos G, Szigyarto M, Sebo N, Paragh G, Zsiros N, Szentimrei R, Pal D, Kobling T, Szanto I, Varadi Z, Bajnok L, Szujo S, Nemes O, Bajnok A, Mezosi E, Bodis B, Marton Z, Konyves L, Farago M, Kiss G, Kiss O, Nagy E, Takacs R, Nyitray S, Abraham G, Fehertemplomi K, Deak L, Dezso E, Karneili E, Deeb D, Zloczower M, Mahmid R, Zolotov S, Hochberg I, Elias M, Goldstein L, Poletaev V, Rock W, Koren O, Saliba W, Wolf F, Adawi F, Nimer A, Mosenzon O, Raz I, Potekhin M, Cahn A, Yulian T, Zvulunov E, Israel H, Shpitz D, Bar-Or I, Chananashvili L, Irena L, Dessau H, Halabe A, Vishlitzky V, Nabriski D, Baraf L, Itelman M, Schiff E, Willner N, Fireman-Klein E, Svistunov V, Dotan Y, Pavlichev O, Saig L, Bashkin A, Kuyantseva E, Gershkov S, Nodelman M, Arbel Y, Bogomolny N, Leshem-Rubinow E, Rofe M, Chorin E, Havkuk O, Wainstein J, Feldman D, Fujino Y, 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Ocicka-Kozakiewicz A, Jurowiecki J, Stasinska T, Karczewicz-Janowska J, Jaruga J, ZytkiewiczJaruga D, Krupinska E, Pupek-Musialik D, Bogdanski P, Szulinska M, Skrypnik D, Skokowska E, Bojarska-Los M, Giermkowska-Samek M, Pirog M, Wojnowski L, Jelinska A, Gradzka M, Danyluk A, Lysek R, Sliwinska T, Podrazka-Szczepaniak A, Barney M, Tomczyk A, Necki M, Malicka J, Dudzinska M, KiszczakBochynska E, Markiewicz A, Galbas K, Paciorkowski A, Mazur S, Mazur M, Chmielowski A, Swiatek A, Sobocka B, Wis J, Jozefowska M, Kaczmarek M, Timler M, Cieplucha Z, Lazuka L, Lazuka N, Wittek A, Spyra J, Jasiel-Wojculewicz H, Stefanski A, Wierucki L, Hanczuk A, Misiura M, Szmygel K, Kolcowa O, Orlowska-Kunikowska E, Rutkowski M, Ignaszewska-Wyrzykowska A, Popenda G, Maciejewska J, Mostowy A, WojteckaGrabka M, Grazyna M, Wieslaw K, Barbara K, Kramarczuk E, Wojciech C, Jaroslaw H, Ewa B, Karas P, Agnieszka S, Hanna C, Justyna S, Piotr K, Wozniak I, Mateusz W, Katarzyna W, Jacek F, Andrzej J, Cymerman K, Gmytrasiewicz M, Zambrzycki J, Krysiak-Kowaluk H, Klodawska K, Klszczewski Z, Zieleniewski J, Opadczuk P, Urbanska K, Faran-Grabowska K, Szczepanik T, Siegel A, Kleczek A, Kincel K, Nowak D, Slowik-Gomulka L, Watemborska-Matuszyk G, Lampart J, Strozik-Krecichwost A, Dziewit T, Broncel M, Wojcik-Odyniec J, Jakubczyk E, Wierzbicka K, Witowicz A, Jedrych B, Korczyk P, Socik-Pojawa M, Monteiro P, Monteiro S, Mendes P, Soares F, Mendes S, Leite L, Vicente J, Santos M, Ferreira A, Alves P, Rosario F, Garrao A, Duarte L, Rogado C, Duarte R, Laginha T, Matos P, Raposo J, Mariz J, Teixeira J, Capela C, Leitao A, Cardiga R, Alface M, Augusto S, Basto L, Cunha A, Rei D, Dantas J, Verdasca I, Andrade L, Silva A, Suarez M, Dias V, Silva J, Pereira N, Goncalves M, Goncalves A, Silveira A, Sampaio A, Dias A, Diogo M, Vilaca C, Cif A, Calin T, Elena S, Crisan C, Adina S, Ramona S, Anghel V, Simona C, Turcu L, Mihaela V, Cosma D, Cristina H, Marius-Calin H, Negrisanu G, Andreea-Andrada M, Maria-Mihaela 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M, Rebecca J, Barker T, Seaton B, Campbell E, Kompanik H, Jayson L, Huffman C, Bialow M, McDonnell G, McCaffrey J, Manis C, DeLuca E, Levins J, Bartlett M, Anorga K, Franco M, Gentry P, Hodge D, Pohil R, Rschultz, Leggett R, Blair L, Gisler J, Niegos F, Osburn M, Parma K, Schendel S, Stines L, Winnie M, Wu P, Canales J, Yu J, Cornett G, Beavins J, Hyde D, Zapinski D, Johnson T, Levinson D, Ahmed A, Kenny B, Kuehl A, Bates C, Jantzi C, Ananthula P, Shafer J, Louthan J, Bays A, Stapleton A, Staton P, Strum D, Taylor P, Smith A, Rapp R, Bao S, Randolph C, MacGillivray B, Schuster R, Harden T, Barnella C, Dunnam T, Whiles R, Bolick C, Brockmyre A, Plucker S, Marshall C, Poteet C, Morin D, Tavel E, Averill N, McFann A, Purcell D, Dixon T, Corey E, Goss J, Drescher R, Irfan M, Naeem M, Egelhof R, Mehta P, Koehler T, Walia J, Fernandez J, Bedel G, Preet R, Bhuchar S, Ahmed F, Onyema D, Benchabbat A, Kohanbash L, Miller P, Lalinde M, Carrithers E, Patterson R, Raube-Miceli A, Martinez A, 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Earl J, McNeill R, Farrington C, Carr K, Nabat M, Matthew S, Yvette E, Handelsman Y, Delkhah S, Ismail Y, Janna C, Akhtar A, Neiman A, Blumenthal S, Colleen V, Schmidt D, Ashraf E, Bhargava A, Khoo T, Langel C, Theuma P, Wright D, Fitzgerald K, Hitchcock J, Capasso-Gulve E, Wolff E, Umpierrez G, Priyathama V, Francisco P, Dawn S, Quraishi A, Kahn B, Ferro F, Hertz B, Phelps J, Campbell A, Downing J, Pangtay D, Pangatay S, Villagran-Solis K, Haseeb M, Rettig K, Kwan R, Cox R, Slimak V, So A, Schmedtje J, Chang A, Douglas Z, McGarity W, Jestel J, Kanade P, Julie J, Asher R, Canaan Y, Perez A, Alonso I, Cutchin R, Koser A, Adeola Y, Brito S, Stocks J, Frandsen B, Weigelt M, Stehouwer E, Ince C, Stephen P, Shadi B, Jeffrey C, Thethi T, Carpio G, McDuffie R, Moreau C, Stell C, Katalenich B, McKendall-Lewis C, Htun W, Conroy K, Lovre D, Galagan R, Olmeda C, Sihota A, Barton A, Beasley R, Nankivel P, Aberle M, Machin I, Porras J, Rodriguez D, Albornoz A, Haidar A, Lopez-Santini R, Rivero G, 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Colfer H, Kane L, Teklinski A, Gadowski G, Levanovich P, Saba F, Confident L, Hossain S, Steinberg B, Philippe B, Choroenthkongtrakal S, Boccalano F, Anand R, Syam V, Manohar A, Suresh P, Madhusudhan P, Patel P, Cambier P, Klonaris J, Cheng W, Fisher S, Schelle M, Reese L, McLean S, Poock J, Hoens J, Rosie A, Welshons R, Dean J, Kuhlman P, Luke R, Lohrbauer L, Cunningham M, Buday P, Lehmann M, Chrzanowski K, Fletcher A, Hargrove J, Harris F, Debs-Perez G, Maiquez A, Cordoves L, Georgescu M, Tayoun H, Munoz F, Ortiz D, Munoz G, Hamzeh I, Misra A, Zhang L, Forgosh L, Loria K, Roncari C, Hommerding J, Morris G, Lebron C, Blake K, LaVenture K, Lange C, Levinson L, Baungarten T, Edevante S, Shawley S, Moyer H, Elliott K, Iachini K, Rajan R, Davis C, Shattuck A, Simon W, Lakin G, Secrist N, Buth D, Steere D, Talbot K, Singh N, Mascolo R, Sloan S, Kmetzo J, Brown J, Carter L, Lawrence M, Arauz-Pacheco C, Lender D, Kozlow W, Cavanaugh L, Wilson J, Gujja P, Akhter F, Khan M, Mohammed A, Satyavolu S, Dev D, Yalamanchili H, Sumeyye C, Fernandes H, Chaleff F, Jancko M, Trenche S, Kaplan W, Wilcox S, Goisse M, Rua M, Black J, Chapman K, Suh D, Yan L, Song D, Chanara S, Houchin V, McKeinness A, Sotolongo R, Gutierrez K, Miranda-Palma B, Solano M, Jain M, Needell J, Banerjee A, Jarratt M, Hantel S, Lees K, Welty F, Freedman S, Parhofer K, Birkeland K, McGill J, Tijssen J, Clemmensen P, Pehrson S, Grande P, Januzzi J, Wood M, Petrie M, Sairanen T, Tatlisumak T, Soinne L, Kase C, Turan T, Mann J, Agarwal R, Fogarty D, Navaneethan S, Srinivas T, Forsmark C, Frossard J, Gelrud A, Mayerle J, Lee R, Heist R, Sullivan R, Buchbinder E, Chodak G, Edelman M, Thompson V, Coles A, and CARMELINA Investigators
- Subjects
cardiovascular disease ,type 2 diabetes mellitus ,heart failure ,chronic kidney diseases - Abstract
Background: Individuals with type 2 diabetes mellitus are at increased risk for heart failure (HF), particularly those with coexisting atherosclerotic cardiovascular disease and/or kidney disease. Some but not all dipeptidyl peptidase-4 inhibitors have been associated with increased HF risk. We performed secondary analyses of HF and related outcomes with the dipeptidyl peptidase-4 inhibitor linagliptin versus placebo in CARMELINA (The Cardiovascular and Renal Microvascular Outcome Study With Linagliptin), a cardiovascular outcomes trial that enrolled participants with type 2 diabetes mellitus and atherosclerotic cardiovascular disease and/or kidney disease. Methods: Participants in 27 countries with type 2 diabetes mellitus and concomitant atherosclerotic cardiovascular disease and/or kidney disease were randomized 1:1 to receive once daily oral linagliptin 5 mg or placebo, on top of standard of care. All hospitalization for HF (hHF), cardiovascular outcomes, and deaths were prospectively captured and centrally adjudicated. In prespecified and post hoc analyses of HF and related events, Cox proportional hazards models adjusting for region and baseline history of HF were used. Recurrent hHF events were analyzed using a negative binomial model. In a subset of participants with left ventricular ejection fraction captured within the year before randomization, HF-related outcomes were assessed in subgroups stratified by left ventricular ejection fraction > or 50%. Results: CARMELINA enrolled 6979 participants (mean age, 65.9 years; estimated glomerular filtration rate, mL/min per 1.73m(2); hemoglobin A1c, 8.0%; 62.9% men; diabetes mellitus duration, 14.8 years), including 1873 (26.8%) with a history of HF at baseline. Median follow-up was 2.2 years. Linagliptin versus placebo did not affect the incidence of hHF (209/3494 [6.0%] versus 226/3485 [6.5%], respectively; hazard ratio [HR], 0.90; 95% CI, 0.74-1.08), the composite of cardiovascular death/hHF (HR, 0.94; 95% CI, 0.82-1.08), or risk for recurrent hHF events (326 versus 359 events, respectively; rate ratio, 0.94; 95% CI, 0.75-1.20). There was no heterogeneity of linagliptin effects on hHF by history of HF at baseline, baseline estimated glomerular filtration rate or urine albumin-creatinine ratio, or prerandomization left ventricular ejection fraction. Conclusions: In a large, international cardiovascular outcome trial in participants with type 2 diabetes mellitus and concomitant atherosclerotic cardiovascular disease and/or kidney disease, linagliptin did not affect the risk of hHF or other selected HF-related outcomes, including among participants with and without a history of HF, across the spectrum of kidney disease, and independent of previous left ventricular ejection fraction. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01897532.
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- 2019
47. Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk The CARMELINA Randomized Clinical Trial
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Satyavolu S, Dev D, Yalamanchili H, Sumeyye C, Fernandes H, Chaleff F, Jancko M, Trenche S, Kaplan W, Wilcox S, Goisse M, Rua M, Black J, Chapman K, Suh D, Yan L, Song D, Chanara S, Houchin V, McKeinness A, Sotolongo R, Gutierrez K, Miranda-Palma B, Solano M, Jain M, Needell J, Banerjee A, Jarratt M, Hantel S, Lees K, Welty F, Freedman S, Parhofer K, Birkeland K, McGill J, Tijssen J, Clemmensen P, Pehrson S, Grande P, Januzzi J, Wood M, Petrie M, Sairanen T, Tatlisumak T, Soinne L, Kase C, Turan T, Mann J, Agarwal R, Fogarty D, Navaneethan S, Srinivas T, Forsmark C, Frossard J, Gelrud A, Mayerle J, Lee R, Heist R, Sullivan R, Buchbinder E, Chodak G, Edelman M, Thompson V, Coles A, and CARMELINA Investigators
- Abstract
IMPORTANCE Type 2 diabetes is associated with increased cardiovascular (CV) risk. Prior trials have demonstrated CV safety of 3 dipeptidyl peptidase 4 (DPP-4) inhibitors but have included limited numbers of patients with high CV risk and chronic kidney disease. OBJECTIVE To evaluate the effect of linagliptin, a selective DPP-4 inhibitor, on CV outcomes and kidney outcomes in patients with type 2 diabetes at high risk of CV and kidney events. DESIGN, SETTING, AND PARTICIPANTS Randomized, placebo-controlled, multicenter noninferiority trial conducted from August 2013 to August 2016 at 605 clinic sites in 27 countries among adults with type 2 diabetes, hemoglobin A(1c) of 6.5% to 10.0%, high CV risk (history of vascular disease and urine-albumin creatinine ratio [UACR] > 200mg/g), and high renal risk (reduced eGFR and micro-or macroalbuminuria). Participants with end-stage renal disease (ESRD) were excluded. Final follow-up occurred on January 18, 2018. INTERVENTIONS Patients were randomized to receive linagliptin, 5 mg once daily (n = 3494), or placebo once daily (n = 3485) added to usual care. Other glucose-lowering medications or insulin could be added based on clinical need and local clinical guidelines. MAIN OUTCOMES AND MEASURES Primary outcomewas time to first occurrence of the composite of CV death, nonfatalmyocardial infarction, or nonfatal stroke. Criteria for noninferiority of linagliptin vs placebo was defined by the upper limit of the 2-sided 95% CI for the hazard ratio (HR) of linagliptin relative to placebo being less than 1.3. Secondary outcome was time to first occurrence of adjudicated death due to renal failure, ESRD, or sustained 40% or higher decrease in eGFR from baseline. RESULTS Of 6991 enrollees, 6979 (mean age, 65.9 years; eGFR, 54.6 mL/min/1.73m2; 80.1% with UACR > 30mg/g) received at least 1 dose of study medication and 98.7% completed the study. During a median follow-up of 2.2 years, the primary outcome occurred in 434 of 3494 (12.4%) and 420 of 3485 (12.1%) in the linagliptin and placebo groups, respectively, (absolute incidence rate difference, 0.13 [95% CI,-0.63 to 0.90] per 100 person-years) (HR, 1.02; 95% CI, 0.89-1.17; P
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- 2019
48. Treatment of copper concentrates containing chalcopyrite and non-ferrous sulphides by the BRISA process
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Carranza, F., Iglesias, N., Mazuelos, A., Palencia, I., and Romero, R.
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- 2004
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49. Nanostructured Chitosan-Based Biomaterials for Sustained and Colon-Specific Resveratrol Release
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Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica, Iglesias, N., Galbis Fuster, Elsa, Díaz Blanco, Manuel Jesús, Lucas Rodríguez, Ricardo, Benito Hernández, Elena María, Paz Báñez, María Violante de, Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica, Iglesias, N., Galbis Fuster, Elsa, Díaz Blanco, Manuel Jesús, Lucas Rodríguez, Ricardo, Benito Hernández, Elena María, and Paz Báñez, María Violante de
- Abstract
In the present work, we demonstrate the preparation of chitosan-based composites as vehicles of the natural occurring multi-drug resveratrol (RES). Such systems are endowed with potential therapeutic effects on inflammatory bowel diseases (IBD), such as Crohn’s disease (CD) and ulcerative colitis, through the sustained colonic release of RES from long-lasting mucoadhesive drug depots. The loading of RES into nanoparticles (NPs) was optimized regarding two independent variables: RES/polymer ratio, and temperature. Twenty experiments were carried out and a Box–Behnken experimental design was used to evaluate the significance of these independent variables related to encapsulation efficiency (EE). The enhanced RES EE values were achieved in 24 h at 39 °C and at RES/polymer ratio of 0.75:1 w/w. Sizes and polydispersities of the optimized NPs were studied by dynamic light scattering (DLS). Chitosan (CTS) dispersions containing the RES-loaded NPs were ionically gelled with tricarballylic acid to yield CTS-NPs composites. Macro- and microscopic features (morphology and porosity studied by SEM and spreadability), thermal stability (studied by TGA), and release kinetics of the RES-loaded CTS-NPs were investigated. Release patterns in simulated colon conditions for 48 h displayed significant differences between the NPs (final cumulative drug release: 79–81%), and the CTS-NPs composites (29–34%).
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- 2019
50. Diagnóstico precoz de la paratuberculosis bovina mediante ELISAs basados en la detección de biomarcadores proteicos
- Author
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European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Blanco-Vázquez, C., Alonso Hearn, M., Juste, R., Balseiro, Ana, Iglesias, N., Copano, F., Amado, J., Canive, M., Casais, R., European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Blanco-Vázquez, C., Alonso Hearn, M., Juste, R., Balseiro, Ana, Iglesias, N., Copano, F., Amado, J., Canive, M., and Casais, R.
- Published
- 2019
Catalog
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