1. Kinetics of circulating levels of miR-195, miR-155 and miR-21 in patients with breast cancer undergoing mastectomy.
- Author
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Igglezou M, Vareli K, Georgiou GK, Sainis I, and Briasoulis E
- Subjects
- Adult, Aged, Biomarkers, Tumor blood, Biomarkers, Tumor genetics, Breast Neoplasms pathology, Breast Neoplasms surgery, Female, Humans, Mastectomy, Middle Aged, Neoplasm Recurrence, Local, Pilot Projects, Postoperative Period, Preoperative Period, Breast Neoplasms blood, MicroRNAs blood, MicroRNAs genetics, Neovascularization, Pathologic blood
- Abstract
Background: MicroRNAs are small RNA molecules that negatively regulate the expression of the majority of proteins, mainly at the post-transcriptional level. Being stable in the circulation and resistant to storage handling, they are potentially promising biomarkers., Materials and Methods: We measured RNA levels of three microRNAs with tumorigenic or angiogenic potential (miR-155, miR-195, and miR-21) in blood samples taken from patients with early breast cancer, both preoperatively and postoperatively., Results: We found that persistently elevated postoperative levels of miR-195 were detected only in patients who developed early tumor relapse and that miR-155 levels tended to increase three days postoperatively (p=0.05) and fell below baseline one month post-surgery (p<0.05). We had no major findings for miR-21., Conclusion: The results of this pilot study indicate a possible involvement of miR-155 in surgery-induced angiogenesis and potential prognostic significance of high postoperative levels of circulating miR-195 in patients with breast cancer., (Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)
- Published
- 2014