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Your search keyword '"Igarashi, Kazuharu"' showing total 121 results
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121 results on '"Igarashi, Kazuharu"'

7. Development of a nomogram to predict outcome after liver resection for hepatocellular carcinoma in Child-Pugh B cirrhosis

Author

Berardi, Giammauro, Morise, Zenichi, Sposito, Carlo, Igarashi, Kazuharu, Panetta, Valentina, Simonelli, Ilaria, Kim, Sungho, Goh, Brian K.P., Kubo, Shoji, Tanaka, Shogo, Takeda, Yutaka, Ettorre, Giuseppe Maria, Wilson, Gregory C., Cimino, Matteo, Chan, Chung-Yip, Torzilli, Guido, Cheung, Tan To, Kaneko, Hironori, Mazzaferro, Vincenzo, Geller, David A., Han, Ho-Seong, Kanazawa, Akishige, Wakabayashi, Go, and Troisi, Roberto Ivan

Published
2020
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11. Comprehensive Exploration to Identify Predictive DNA Markers of ΔNp63/SOX2 in Drug Resistance in Human Esophageal Squamous Cell Carcinoma

Author

Ooizumi, Yosuke, Kojima, Keita, Igarashi, Kazuharu, Tanaka, Yoko, Harada, Hiroki, Yokota, Kazuko, Kaida, Takeshi, Ishii, Satoru, Tanaka, Toshimichi, Yokoi, Keigo, Nishizawa, Nobuyuki, Washio, Marie, Ushiku, Hideki, Katoh, Hiroshi, Kosaka, Yoshimasa, Mieno, Hiroaki, Hosoda, Kei, Watanabe, Masahiko, Katada, Chikatoshi, Hiki, Naoki, and Yamashita, Keishi

Published
2019
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13. Utility of Robot-assisted Laparoscopic Transabdominal Preperitoneal Repair of Inguinal Hernia Following Robot-assisted Laparoscopic Radical Prostatectomy

Author

FUNAMIZU, NAOTAKE, MINETA, SHO, OZAKI, TAKAHIRO, MISHIMA, KOHEI, IGARASHI, KAZUHARU, OMURA, KENJI, TAKADA, YASUTSUGU, and WAKABAYASHI, GO

Subjects
Male, Prostatectomy, Pharmacology, Cancer Research, Humans, Female, Hernia, Inguinal, Laparoscopy, Prospective Studies, Robotics, General Biochemistry, Genetics and Molecular Biology, Research Article, Retrospective Studies
Abstract

Background: To evaluate the utility of robot-assisted laparoscopic transabdominal preperitoneal repair (R-TAPP) of postprostatectomy inguinal hernia (PIH) in patients who underwent robot-assisted laparoscopic radical prostatectomy (RALP). Patients and Methods: This was a prospective, single-centre retrospective cohort study. R-TAPP was conducted in 74 consecutive patients from September 2016 to March 2020. With the exception of women and patients who underwent previous abdominal surgery, 70 patients were classified into two groups based on the absence or presence of PIH. Their data were retrospectively compared to those who had not undergone RALP. Results: The median operative time for the PIH group was longer compared to the non-PIH group. However, postoperative complications, including seroma formation, haematoma and surgical site infections, were not significantly different between the groups. The estimated blood loss was small, and hospitalisation duration was 1 day in all cases. Moreover, there were no hernia recurrences within the 90-day follow-up period in either group. Conclusion: R-TAPP is a feasible and safe approach for inguinal hernia repair, even in patients who undergo RALP for prostate cancer.

Published
2022
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17. Evaluation of accuracy of laparoscopic liver mono‐segmentectomy using the Glissonian approach with indocyanine green fluorescence negative staining by comparing estimated and actual resection volumes: A single‐center retrospective cohort study

Author

Funamizu, Naotake, primary, Ozaki, Takahiro, additional, Mishima, Kohei, additional, Igarashi, Kazuharu, additional, Omura, Kenji, additional, Takada, Yasutsugu, additional, and Wakabayashi, Go, additional

Published
2021
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20. Outcomes of Distal Gastrectomy for Elderly Patients With Advanced Gastric Cancer: Comparison With Non-Elderly Patients and the Utility of Laparoscopic Distal Gastrectomy for Elderly Patients

Author

Shimada, Ayako, primary, Ishii, Satoru, additional, Tanaka, Hiroto, additional, Okamoto, Tomomi, additional, Mishima, Kohei, additional, Nakanishi, Ryo, additional, Hosaka, Miki, additional, Ozaki, Takahiro, additional, Igarashi, Kazuharu, additional, Honda, Masayuki, additional, Funamizu, Naotake, additional, Tsutsui, Atsuko, additional, Omura, Kenji, additional, and Wakabayashi, Go, additional

Published
2021
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32. Diagnostic potential of hypermethylation of the cysteine dioxygenase 1 gene (CDO 1) promoter DNA in pancreatic cancer

Author

Nishizawa, Nobuyuki, primary, Harada, Hiroki, additional, Kumamoto, Yusuke, additional, Kaizu, Takashi, additional, Katoh, Hiroshi, additional, Tajima, Hiroshi, additional, Ushiku, Hideki, additional, Yokoi, Keigo, additional, Igarashi, Kazuharu, additional, Fujiyama, Yoshiki, additional, Okuwaki, Kosuke, additional, Iwai, Tomohisa, additional, Watanabe, Masahiko, additional, and Yamashita, Keishi, additional

Published
2019
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34. Prediction of onset of remnant gastric cancer by promoter DNA methylation of CDO1/HOPX/Reprimo/E-cadherin

Author

Kojima, Keita, primary, Minatani, Naoko, additional, Ushiku, Hideki, additional, Ishii, Satoru, additional, Tanaka, Toshimichi, additional, Yokoi, Keigo, additional, Nishizawa, Nobuyuki, additional, Ooizumi, Yosuke, additional, Igarashi, Kazuharu, additional, Hosoda, Kei, additional, Moriya, Hiromitsu, additional, Mieno, Hiroaki, additional, Watanabe, Masahiko, additional, and Yamashita, Keishi, additional

Published
2019
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36. Clinical significance of cancer specific methylation of the CDO1 gene in small bowel cancer

Author

Kojima, Keita, primary, Nakamura, Takatoshi, additional, Ooizumi, Yosuke, additional, Igarashi, Kazuharu, additional, Tanaka, Toshimichi, additional, Yokoi, Keigo, additional, Ishii, Satoru, additional, Nishizawa, Nobuyuki, additional, Katoh, Hiroshi, additional, Kosaka, Yoshimasa, additional, Sato, Takeo, additional, Watanabe, Masahiko, additional, and Yamashita, Keishi, additional

Published
2019
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40. Dissected peripancreatic tissue margin is a critical prognostic factor and is associated with a K‑ras gene mutation in pancreatic ductal adenocarcinoma

Author

Nishizawa, Nobuyuki, primary, Kumamoto, Yusuke, additional, Katoh, Hiroshi, additional, Ushiku, Hideki, additional, Yokoi, Keigo, additional, Tanaka, Toshimichi, additional, Ishii, Satoru, additional, Igarashi, Kazuharu, additional, Tajima, Hiroshi, additional, Kaizu, Takashi, additional, Yoshida, Tsutomu, additional, Saegusa, Makoto, additional, Watanabe, Masahiko, additional, and Yamashita, Keishi, additional

Published
2018
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43. Cysteine dioxygenase type 1 (CDO1) gene promoter methylation during the adenoma-carcinoma sequence in colorectal cancer

Author

Kojima, Keita, primary, Nakamura, Takatoshi, additional, Ohbu, Makoto, additional, Katoh, Hiroshi, additional, Ooizumi, Yosuke, additional, Igarashi, Kazuharu, additional, Ishii, Satoru, additional, Tanaka, Toshimichi, additional, Yokoi, Keigo, additional, Nishizawa, Nobuyuki, additional, Yokota, Kazuko, additional, Kosaka, Yoshimasa, additional, Sato, Takeo, additional, Watanabe, Masahiko, additional, and Yamashita, Keishi, additional

Published
2018
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44. Prognostic significance of promoter DNA hypermethylation of the cysteine dioxygenase 1 (CDO1) gene in primary gallbladder cancer and gallbladder disease

Author

Igarashi, Kazuharu, primary, Yamashita, Keishi, additional, Katoh, Hiroshi, additional, Kojima, Keita, additional, Ooizumi, Yosuke, additional, Nishizawa, Nobuyuki, additional, Nishiyama, Ryo, additional, Kawamata, Hiroshi, additional, Tajima, Hiroshi, additional, Kaizu, Takashi, additional, Kumamoto, Yusuke, additional, and Watanabe, Masahiko, additional

Published
2017
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45. Diagnostic potential of hypermethylation of the cysteine dioxygenase 1 gene (CDO1) promoter DNA in pancreatic cancer.

Author

Nishizawa, Nobuyuki, Harada, Hiroki, Kumamoto, Yusuke, Kaizu, Takashi, Katoh, Hiroshi, Tajima, Hiroshi, Ushiku, Hideki, Yokoi, Keigo, Igarashi, Kazuharu, Fujiyama, Yoshiki, Okuwaki, Kosuke, Iwai, Tomohisa, Watanabe, Masahiko, and Yamashita, Keishi

Abstract

DNA markers for pancreatic ductal adenocarcinoma (PDAC) are urgently needed for detection of minimally invasive disease. The epigenetic relevance of the cysteine dioxygenase 1 gene (CDO1) has been never investigated in PDAC. Three studies, including cellular experiments, tissue validation, and pilot testing for pancreatic cytology, were carried out. Promoter DNA methylation value (MV) of CDO1 was quantified by quantitative methylation‐specific PCR. CDO1 expression was consistent with its promoter DNA methylation in 7 PDAC cell lines. In 160 retrospectively collected primary PDAC tumor tissues, MV was significantly higher compared to the corresponding noncancerous pancreas (area under the receiver operating characteristic curve [AUC] = 0.97, P < .0001), and CDO1 hypermethylation was highly specific to PDAC tumor tissues. CDO1 hypermethylation group (MV over 19) was significantly associated with diverse prognostic factors in PDAC. Surprisingly, it was significantly higher in prospectively collected PDAC cytology samples (n = 37), including both pancreatic juice (n = 12) and endoscopic ultrasound‐fine needle aspiration (EUS‐FNA) cytology (n = 25) compared to pancreatic benign diseases (AUC = 0.96, P < .0001). Detection of PDAC was confirmed by DNA testing in 35 of 37 patients (95% sensitivity); thus, it was more sensitive than cytology (33%) or EUS‐FNA cytology (88%). Promoter DNA methylation of CDO1 is extremely specific for PDAC tumors, and accumulates with PDAC tumor progression. It could be a definitive diagnostic marker of PDAC in pancreatic juice or EUS‐FNA cytology. [ABSTRACT FROM AUTHOR]

Published
2019
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46. Dissected peripancreatic tissue margin is a critical prognostic factor and is associated with a K-ras gene mutation in pancreatic ductal adenocarcinoma.

Author

Nishizawa, Nobuyuki, Kumamoto, Yusuke, Katoh, Hiroshi, Ushiku, Hideki, Yokoi, Keigo, Tanaka, Toshimichi, Ishii, Satoru, Igarashi, Kazuharu, Tajima, Hiroshi, Kaizu, Takashi, Yoshida, Tsutomu, Saegusa, Makoto, Watanabe, Masahiko, and Yamashita, Keishi

Subjects
PANCREATECTOMY, PROPORTIONAL hazards models, ANTIGENS, RELEVANCE, TISSUES
Abstract

We previously reported that the dissected pancreatic tissue margin (DPM) and the preoperative serum level of carbohydrate antigen 19-9 (preCA19-9) were independent prognostic factors in pancreatic ductal adenocarcinoma (PDAC). In the current study, the prognostic relevance of these factors, including their molecular associations, were validated. A total of 161 patients with PDAC underwent a pancreatectomy between 1986 and 2013, and a multivariate Cox proportional hazards model and a propensity score-based model validated the prognostic importance of DPM. The prognostic factors were compared with the mutation profiles of the K-ras and TP53 genes. Univariate prognostic analysis of disease-specific survival (DSS) demonstrated that DPM (P<0.0001), preCA19-9 (P<0.0001) and Union for International Cancer Control (UICC) stage (P<0.0001), were all significantly associated with poor outcome in PDAC. A multivariate Cox proportional hazards model confirmed that preCA19-9 (P=0.0002) and DPM (P=0.0002) remained as prognostic factors independent of UICC stage (P=0.0015). The combination of preCA19-9 and DPM to predict prognosis could accurately identify the long-term survivors of PDAC (70% 5-year DSS), and a multivariate logistic regression model identified that DPM was the most effective predictor of mortality. The prognostic relevance of DPM was also confirmed (P=0.0008) through propensity score-based background adjustment of patient bias. K-ras gene mutation was significantly associated with DPM (P=0.0002), and DPM-positive patients demonstrated recurrence of distant metastasis in 67% of cases. Therefore, DPM is a critical prognostic indicator in PDAC. In combination with preCA19-9, DPM may be useful to identify long-term survivors of PDAC. Furthermore, to the best of our knowledge, the current study was the first to discover that DPM can represent a poor prognosis based putatively on its association with the K-ras gene mutation. [ABSTRACT FROM AUTHOR]

Published
2019

49. A Case of Primary Malignant Solitary Fibrous Tumor of the Pancreas

Author

Yamanashi, Takahiro, primary, Toriumi, Fumiki, additional, Yahagi, Masashi, additional, Shiratori, Fumiaki, additional, Igarashi, Kazuharu, additional, Nishi, Tomohiko, additional, Handa, Kan, additional, Sekine, Kazuhiko, additional, Mukai, Kiyoshi, additional, and Shimoyama, Yutaka, additional

Published
2012
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50. [A Case of Delayed Anastomotic Leakage after Ileocecal Resection in a Hemodialysis Patient].

Author

Nakanishi R, Tsutsui A, Tanaka H, Hagiwara C, Igarashi K, Okamoto N, Oomura K, and Wakabayash G

Subjects
Aged, Anastomosis, Surgical, Anastomotic Leak etiology, Anastomotic Leak surgery, Humans, Male, Renal Dialysis, Retrospective Studies, Laparoscopy, Neoplasms, Rectal Neoplasms surgery
Abstract

A 66-year-old man was referred to our department with the diagnosis of ascending colon cancer. He was undergoing dialysis for chronic renal failure due to diabetic nephropathy. Laparoscopic ileocecal resection was planned for the ascending colon cancer, but the procedure was converted to laparotomy owing to intraoperative bleeding. The patient was discharged from the hospital after 7 days. On the 14th postoperative day, the patient presented with purulent drainage from the wound and fever and was diagnosed to have a minor anastomotic leak. The suture of the anterior sheath was exposed in part of the wound. The patient's general condition was stable, and conservative treatment was planned. However, when he coughed, the wound separated and the intestine prolapsed, and emergency surgery was performed. Intraoperative findings showed leakage of intestinal fluid from the anastomotic border, and we diagnosed delayed suture failure. We present a rare case of delayed anastomotic leakage in a hemodialysis patient.

Published
2022

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