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9 results on '"Ifesemen, Onosi S."'

2. The efficacy of systemic glucocorticosteroids for pain in rheumatoid arthritis: a systematic literature review and meta-analysis

Author

McWilliams, Daniel F, Walsh, David A, Jones-Diette, Julie, Thankaraj, Divya, Ifesemen, Onosi S, Morgan, Rheinallt, and Shenker, Nicholas G

Subjects
Rheumatology, Bio/Medical/Health - Clinical Medicine, Pharmacology (medical), Arthritis Research Campaign National Pain Centre, Biomedical Research Centre
Abstract

Background: Glucocorticosteroids (GCs) are recommended to suppress inflammation in people with active RA. This systematic review and meta-analysis aimed to quantify the effects of systemic GCs on RA pain.Methods: A systematic literature review of randomised controlled trials (RCTs) in RA comparing systemic GCs to inactive treatment. Three databases were and spontaneous pain and evoked pain outcomes were extracted. Standardized mean differences (SMDs) and mean differences (MDs) were meta-analysed. Heterogeneity (I², tau statistics) and bias (funnel plot, Eggers test) were assessed. Subgroup analyses investigated sources of variation. This study was pre-registered (PROSPERO CRD42019111562). Results: 18903 titles, 880 abstracts and 226 full texts were assessed. Thirty three RCTs suitable for the meta-analysis included 2658 participants. Pain scores (spontaneous pain) decreased in participants treated with oral GCs; SMD= -0.65 (15 studies, 95% CI, -0.82, -0.49, p3 to 6 months, and -6mm (95% CI, -10mm, -2mm) at >6 months. Similar findings were obtained when evoked pain outcomes were examined. Data from 5 RCTs suggested improvement also in fatigue during GC treatment.Discussion. Oral GCs are analgesic in RA. The benefit is greatest shortly after initiation and GCs might not achieve clinically important pain relief beyond 3 months. Treatments other than anti-inflammatory GCs should be considered to reduce the long-term burden of pain in RA.

Published
2021

3. Additional file 2 of Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA): protocol for a prospective observational study

Author

Ifesemen, Onosi S., McWilliams, Daniel F., Ferguson, Eamonn, Wakefield, Richard, Akin-Akinyosoye, Kehinde, Wilson, Deborah, Platts, Dorothy, Ledbury, Susan, and Walsh, David A.

Abstract

Additional file 2: Supplement 2. CAP-RA PIS final version 1.218082020. CAP-RA Participant Information Sheet, describing the study protocol to potential participants and members of the public in lay language.

Published
2021
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4. Additional file 1 of Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA): protocol for a prospective observational study

Author

Ifesemen, Onosi S., McWilliams, Daniel F., Ferguson, Eamonn, Wakefield, Richard, Akin-Akinyosoye, Kehinde, Wilson, Deborah, Platts, Dorothy, Ledbury, Susan, and Walsh, David A.

Subjects
education, food and beverages, humanities
Abstract

Additional file 1: Supplement 1. SPIRIT Checklist describing protocol items for clinical trials.

Published
2021
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5. Additional file 3 of Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA): protocol for a prospective observational study

Author

Ifesemen, Onosi S., McWilliams, Daniel F., Ferguson, Eamonn, Wakefield, Richard, Akin-Akinyosoye, Kehinde, Wilson, Deborah, Platts, Dorothy, Ledbury, Susan, and Walsh, David A.

Subjects
humanities
Abstract

Additional file 3: Supplement 3. CAP-RA consent form final version 1.423092020 CAP-RA study participant consent form.

Published
2021
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8. efficacy of systemic glucocorticosteroids for pain in rheumatoid arthritis: a systematic literature review and meta-analysis.

Author

McWilliams, Daniel F, Thankaraj, Divya, Jones-Diette, Julie, Morgan, Rheinallt, Ifesemen, Onosi S, Shenker, Nicholas G, and Walsh, David A

Subjects
THERAPEUTIC use of glucocorticoids, DRUG efficacy, GLUCOCORTICOIDS, PAIN measurement, META-analysis, CONFIDENCE intervals, SYSTEMATIC reviews, VISUAL analog scale, TREATMENT duration, RHEUMATOID arthritis, DESCRIPTIVE statistics, PAIN management, EVALUATION
Abstract

Objectives Glucocorticosteroids (GCs) are recommended to suppress inflammation in people with active RA. This systematic review and meta-analysis aimed to quantify the effects of systemic GCs on RA pain. Methods A systematic literature review of randomized controlled trials (RCTs) in RA comparing systemic GCs to inactive treatment. Three databases were and spontaneous pain and evoked pain outcomes were extracted. Standardized mean differences (SMDs) and mean differences were meta-analysed. Heterogeneity (I 2, tau statistics) and bias (funnel plot, Egger's test) were assessed. Subgroup analyses investigated sources of variation. This study was pre-registered (PROSPERO CRD42019111562). Results A total of 18 903 titles, 880 abstracts and 226 full texts were assessed. Thirty-three RCTs suitable for the meta-analysis included 3123 participants. Pain scores (spontaneous pain) decreased in participants treated with oral GCs; SMD = −0.65 (15 studies, 95% CI −0.82, −0.49, P <0.001) with significant heterogeneity (I 2 = 56%, P =0.0002). Efficacy displayed time-related decreases after GC initiation. Mean difference visual analogue scale pain was −15 mm (95% CI −20, −9) greater improvement in GC than control at ≤3 months, −8 mm (95% CI −12, −3) at >3–6 months and −7 mm (95% CI −13, 0) at >6 months. Similar findings were obtained when evoked pain outcomes were examined. Data from five RCTs suggested improvement also in fatigue during GC treatment. Conclusion Oral GCs are analgesic in RA. The benefit is greatest shortly after initiation and GCs might not achieve clinically important pain relief beyond 3 months. Treatments other than anti-inflammatory GCs should be considered to reduce the long-term burden of pain in RA. [ABSTRACT FROM AUTHOR]

Published
2022
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