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7. The SGLT2 inhibitor dapagliflozin improves kidney function in glycogen storage disease XI

Author

Trepiccione, Francesco, primary, Iervolino, Anna, additional, D’Acierno, Mariavittoria, additional, Siccardi, Sabrina, additional, Costanzo, Vincenzo, additional, Sardella, Donato, additional, De La Motte, Luigi R., additional, D’Apolito, Luciano, additional, Miele, Antonio, additional, Perna, Alessandra F., additional, Capolongo, Giovanna, additional, Zacchia, Miriam, additional, Frische, Sebastian, additional, Nielsen, Rikke, additional, Staiano, Leopoldo, additional, Sambri, Irene, additional, De Cegli, Rossella, additional, Unwin, Robert, additional, Eladari, Dominique, additional, and Capasso, Giovambattista, additional

Published
2023
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8. Thromboembolic Events after COVID-19 Vaccination: An Italian Retrospective Real-World Safety Study

Author

Bernardi, Francesca Futura, primary, Mascolo, Annamaria, additional, Sarno, Marina, additional, Capoluongo, Nicolina, additional, Trama, Ugo, additional, Ruggiero, Rosanna, additional, Sportiello, Liberata, additional, Fusco, Giovanni Maria, additional, Bisogno, Massimo, additional, Coscioni, Enrico, additional, Iervolino, Anna, additional, Di Micco, Pierpaolo, additional, Capuano, Annalisa, additional, and Perrella, Alessandro, additional

Published
2023
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10. Animal models to study cognitive impairment of chronic kidney disease.

Author

Silva, Pedro H. Imenez, Pepin, Marion, Figurek, Andreja, Gutiérrez-Jiménez, Eugenio, Bobot, Mickaël, Iervolino, Anna, Mattace-Raso, Francesco, Hoorn, Ewout J., Bailey, Matthew A., Hénaut, Lucie, Nielsen, Rikke, Frische, Sebastian, Trepiccione, Francesco, Hafez, Gaye, Altunkaynak, Hande O., Endlich, Nicole, Unwin, Robert, Capasso, Giovambattista, Pesic, Vesna, and Massy, Ziad

Subjects
CHRONIC kidney failure, COGNITION disorders, EXECUTIVE function, ACTIVITIES of daily living, COGNITION
Abstract

Mild cognitive impairment (MCI) is common in people with chronic kidney disease (CKD), and its prevalence increases with progressive loss of kidney function. MCI is characterized by a decline in cognitive performance greater than expected for an individual age and education level but with minimal impairment of instrumental activities of daily living. Deterioration can affect one or several cognitive domains (attention, memory, executive functions, language, and perceptual motor or social cognition). Given the increasing prevalence of kidney disease, more and more people with CKD will also develop MCI causing an enormous disease burden for these individuals, their relatives, and society. However, the underlying pathomechanisms are poorly understood, and current therapies mostly aim at supporting patients in their daily lives. This illustrates the urgent need to elucidate the pathogenesis and potential therapeutic targets and test novel therapies in appropriate preclinical models. Here, we will outline the necessary criteria for experimental modeling of cognitive disorders in CKD. We discuss the use of mice, rats, and zebrafish as model systems and present valuable techniques through which kidney function and cognitive impairment can be assessed in this setting. Our objective is to enable researchers to overcome hurdles and accelerate preclinical research aimed at improving the therapy of people with CKD and MCI. [ABSTRACT FROM AUTHOR]

Published
2024
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11. NF-κB Essential Modulator (NEMO) Is Critical for Thyroid Function

Author

Reale, Carla, Iervolino, Anna, Scudiero, Ivan, Ferravante, Angela, D'Andrea, Luca Egildo, Mazzone, Pellegrino, Zotti, Tiziana, Leonardi, Antonio, Roberto, Luca, Zannini, Mariastella, de Cristofaro, Tiziana, Shanmugakonar, Muralitharan, Capasso, Giovambattista, Pasparakis, Manolis, Vito, Pasquale, and Stilo, Romania

Published
2016
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13. Animal models to study cognitive impairment of chronic kidney disease

Author

Imenez Silva, Pedro H., Pepin, Marion, Figurek, Andreja, Gutiérrez-Jiménez, Eugenio, Bobot, Mickaël, Iervolino, Anna, Mattace-Raso, Francesco, Hoorn, Ewout J., Bailey, Matthew A., Hénaut, Lucie, Nielsen, Rikke, Frische, Sebastian, Trepiccione, Francesco, Hafez, Gaye, Altunkaynak, Hande O., Endlich, Nicole, Unwin, Robert, Capasso, Giovambattista, Pesic, Vesna, Massy, Ziad, and Wagner, Carsten A.

Published
2024
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15. Dapagliflozin Prevents Kidney Glycogen Accumulation and Improves Renal Proximal Tubule Cell Functions in a Mouse Model of Glycogen Storage Disease Type 1b

Author

D’Acierno, Mariavittoria, primary, Resaz, Roberta, additional, Iervolino, Anna, additional, Nielsen, Rikke, additional, Sardella, Donato, additional, Siccardi, Sabrina, additional, Costanzo, Vincenzo, additional, D’Apolito, Luciano, additional, Suzumoto, Yoko, additional, Segalerba, Daniela, additional, Astigiano, Simonetta, additional, Perna, Alessandra F., additional, Capasso, Giovambattista, additional, Eva, Alessandra, additional, and Trepiccione, Francesco, additional

Published
2022
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16. Safety and immunogenicity of the COVID-19 vaccine BNT162b2 for patients with breast and gynecological cancer on active anticancer therapy: Results of a prospective observational study

Author

De Placido, Pietro, primary, Pietroluongo, Erica, additional, De Angelis, Carmine, additional, Tafuro, Margherita, additional, Barraco, Chiara, additional, Giannatiempo, Rosa, additional, Buonaiuto, Roberto, additional, Schettini, Francesco, additional, Iervolino, Anna, additional, Vozzella, Emilia Anna, additional, Giuliano, Mario, additional, Bianco, Roberto, additional, and Arpino, Grazia, additional

Published
2022
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17. miRNA-23a modulates sodium-hydrogen exchanger 1 expression: studies in medullary thick ascending limb of salt-induced hypertensive rats

Author

Lombari, Patrizia, primary, Mallardo, Massimo, additional, Petrazzuolo, Oriana, additional, Amruthraj Nagoth, Joseph, additional, Fiume, Giuseppe, additional, Scanni, Roberto, additional, Iervolino, Anna, additional, Damiano, Sara, additional, Coppola, Annapaola, additional, Borriello, Margherita, additional, Ingrosso, Diego, additional, Perna, Alessandra F, additional, Zacchia, Miriam, additional, Trepiccione, Francesco, additional, and Capasso, Giovambattista, additional

Published
2022
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18. MO675: A New in Vivo Multi-Photon Microscopy Based Approach to Study the Peritoneal Membrane Changes Induced by Peritoneal Dialysis

Author

D'apolito, Luciano, primary, Costanzo, Vincenzo, additional, Iervolino, Anna, additional, Sardella, Donato, additional, Frische, Sebastian, additional, Perri, Anna, additional, Bonofiglio, Renzo, additional, Puoci, Francesco, additional, Capasso, Giovambattista, additional, and Trepiccione, Francesco, additional

Published
2022
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21. Efficacy of a Virtual Reality Program in Pediatric Surgery to Reduce Anxiety and Distress Symptoms in the Preoperative Phase: A Prospective Randomized Clinical Trial

Author

Esposito, Ciro, primary, Autorino, Giuseppe, additional, Iervolino, Anna, additional, Vozzella, Emilia Anna, additional, Cerulo, Mariapina, additional, Esposito, Giovanni, additional, Coppola, Vincenzo, additional, Carulli, Roberto, additional, Cortese, Giuseppe, additional, Gallo, Luigi, additional, and Escolino, Maria, additional

Published
2022
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22. The DiaCoVAb Study in South Italy: Immune Response to SARS-CoV-2 Vaccination in Dialysis Patients

Author

Fucci, Alessandra, primary, Giacobbe, Simona, additional, Guerriero, Ilaria, additional, Suzumoto, Yoko, additional, D’Andrea, Egildo Luca, additional, Scrima, Marianna, additional, Nolli, Maria Luisa, additional, Iervolino, Anna, additional, Chiuchiolo, Luigi Amedeo, additional, Salvatore, Ermanno, additional, Renzulli, Roberta, additional, La Peccerella, Ludovico, additional, Marra, Giuseppe, additional, Liuzzi, Marco, additional, Santoro, Domenico, additional, Zulli, Enrico, additional, Gentile, Romolo, additional, Clemente, Gennaro, additional, and Capasso, Giovambattista, additional

Published
2022
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23. miRNA-23a modulates sodium-hydrogen exchanger 1 expression: studies in medullary thick ascending limb of salt-induced hypertensive rats.

Author

Lombari, Patrizia, Mallardo, Massimo, Petrazzuolo, Oriana, Nagoth, Joseph Amruthraj, Fiume, Giuseppe, Scanni, Roberto, Iervolino, Anna, Damiano, Sara, Coppola, Annapaola, Borriello, Margherita, Ingrosso, Diego, Perna, Alessandra F, Zacchia, Miriam, Trepiccione, Francesco, and Capasso, Giovambattista

Subjects
GENE expression, REGULATION of blood pressure, GENETIC vectors, ESSENTIAL hypertension, HYPERTENSION
Abstract

Background The kidney is the main organ in the pathophysiology of essential hypertension. Although most bicarbonate reabsorption occurs in the proximal tubule, the medullary thick ascending limb (mTAL) of the nephron also maintains acid–base balance by contributing to 25% of bicarbonate reabsorption. A crucial element in this regulation is the sodium-hydrogen exchanger 1 (NHE1), a ubiquitous membrane protein controlling intracellular pH, where proton extrusion is driven by the inward sodium flux. MicroRNA (miRNA) expression of hypertensive patients significantly differs from that of normotensive subjects. The aim of this study was to determine the functional role of miRNA alterations at the mTAL level. Methods By miRNA microarray analysis, we identified miRNA expression profiles in isolated mTALs from high sodium intake–induced hypertensive rats (HSD) versus their normotensive counterparts (NSD). In vitro validation was carried out in rat mTAL cells. Results Five miRNAs involved in the onset of salt-sensitive hypertension were identified, including miR-23a, which was bioinformatically predicted to target NHE1 mRNA. Data demonstrated that miRNA-23a is downregulated in the mTAL of HSD rats while NHE1 is upregulated. Consistently, transfection of an miRNA-23a mimic in an mTAL cell line, using a viral vector, resulted in NHE1 downregulation. Conclusion NHE1, a protein involved in sodium reabsorption at the mTAL level and blood pressure regulation, is upregulated in our model. This was due to a downregulation of miRNA-23a. Expression levels of this miRNA are influenced by high sodium intake in the mTALs of rats. The downregulation of miRNA-23a in humans affected by essential hypertension corroborate our data and point to the potential role of miRNA-23a in the regulation of mTAL function following high salt intake. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Telemedicine: A cornerstone of healthcare assistance during the recent pandemic outbreak of COVID-19 but also a great opportunity for the future. A pilot experience in the largest Teaching Hospital in Southern Italy

Author

Tartaglia Edoardo, Vozzella Emilia Anna, LLD Iervolino Anna, Egidio Rosanna, Buonocore Gaetano, EngD Perrone Antonietta, EngD Toscano Gugliemo, EngD Tremante Raffaele, EngD Cesaro Francesca, Sommella Vincenzo, Magri Paola, and Iodice Lanfranco

Abstract

Background: At the end of 2019, Wuhan, China, experienced an outbreak of a novel coronavirus. The epidemiologic burden of COVID-19 is constantly evolving, with numbers of infected persons, hospital admissions and deaths growing near exponentially. The recent pandemic outbreak of COVID-19 worldwide caught the health care systems in every country around the world by storm and without a proper defense mechanism to cope and control such a pandemic. In fact, this outbreak is causing an overwhelming burden of illnesses that stresses health system capacity and adverse effects on healthcare workers including the risk of infection. In this context, telemedicine has been promoted and scaled up to reduce the risk of transmission. In this paper the Authors reports their own experience with Telemedicine. Methods: During the “lockdown”, the AOU“Federico II” was forced to create peculiar pathways to ensure the safety of the patients and medical staff, and to keep an appropriate medical assistance, therefore it was introduced the telemedicine, wherever possible, by modifying the Information Technology (IT) related to the waiting times, rescheduling all booked visits and identifying several outpatient’s clinics suitable for telemedicine activities. Besides, safe pathways were properly studied to screening all patients who had a medical consult in person.Results: Since the introduction of telemedicine service, 953 consultations were provided in this way, about 13 % of all medical consults delivered by AOU “Federico II” in this period; 97,38% of them were follow-up visits, that otherwise would have been missed during the current pandemic, so an economic loss has been avoided. In addition, it has been calculated that, using Telemedicine visits vs a face-to-face consultation, about 65-70% of direct costs were spared by our Healthcare Company.Conclusions: Telemedicine has been the keystone that has allowed a rapid, appropriate response of whole overloaded healthcare systems to current Pandemic, and, as reported by Ohannessian et al., all stakeholders are encouraged to address the challenges and collaborate to promote the safe and evidence-based use of telemedicine during the current pandemic and future outbreaks, and the COVID-19 pandemic is a call to adopt the necessary regulatory changes supporting wide adoption of telemedicine.

Published
2020
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27. Dysregulation of Principal Cell miRNAs Facilitates Epigenetic Regulation of AQP2 and Results in Nephrogenic Diabetes Insipidus

Author

Petrillo, Federica, primary, Iervolino, Anna, additional, Angrisano, Tiziana, additional, Jelen, Sabina, additional, Costanzo, Vincenzo, additional, D’Acierno, Mariavittoria, additional, Cheng, Lei, additional, Wu, Qi, additional, Guerriero, Ilaria, additional, Mazzarella, Maria Cristina, additional, De Falco, Alfonso, additional, D’Angelo, Fulvio, additional, Ceccarelli, Michele, additional, Caraglia, Michele, additional, Capasso, Giovambattista, additional, Fenton, Robert A., additional, and Trepiccione, Francesco, additional

Published
2021
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32. A new recombinant MnSOD prevents the Cyclosporine A-induced renal impairment

Author

Damiano, Sara, Trepiccione, Francesco, Ciarcia, Roberto, Scanni, Roberto, Spagnuolo, Manuela, Manco, Leonida, Borrelli, Antonella, Capasso, Clemente, Mancini, Roberto, Schiattarella, Antonella, Iervolino, Anna, Zacchia, Enza, Bata-Csere, Andrea, Florio, Salvatore, Anastasio, Pietro, Pollastro, Rosamaria, Mancini, Aldo, and Capasso, Giovambattista

Published
2013
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33. Prolonged podocyte depletion in larval zebrafish resembles mammalian focal and segmental glomerulosclerosis

Author

Hansen, Kerrin Ursula Ingeborg, primary, Siegerist, Florian, additional, Daniel, Sophie, additional, Schindler, Maximilian, additional, Iervolino, Anna, additional, Blumenthal, Antje, additional, Daniel, Christoph, additional, Amann, Kerstin, additional, Zhou, Weibin, additional, Endlich, Karlhans, additional, and Endlich, Nicole, additional

Published
2020
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37. Insight into Nephrocan Function in Mouse Endoderm Patterning

Author

Addeo, Martina, primary, Buonaiuto, Silvia, additional, Guerriero, Ilaria, additional, Amendola, Elena, additional, Visconte, Feliciano, additional, Marino, Antonio, additional, De Angelis, Maria Teresa, additional, Russo, Filomena, additional, Roberto, Luca, additional, Marotta, Pina, additional, Russo, Nicola Antonino, additional, Iervolino, Anna, additional, Amodio, Federica, additional, De Felice, Mario, additional, Lucci, Valeria, additional, and Falco, Geppino, additional

Published
2019
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38. SP014RENAL PHENOTYPE OF A MOUSE MODEL OF GLYCOGENOSIS I TYPE B

Author

D’Acierno, Mariavittoria, primary, Resaz, Roberta, additional, Iervolino, Anna, additional, De La Motte, Luigi R, additional, Siccardi, Sabrina, additional, Suzumoto, Yoko, additional, Capasso, Giovambattista, additional, Eva, Alessandra, additional, and Trepiccione, Francesco, additional

Published
2019
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41. MicroRNAs in Renal Diseases: A Potential Novel Therapeutic Target

Author

Petrillo, Federica, Iervolino, Anna, Zacchia, Miriam, Simeoni, Adelina, Masella, Cristina, Capolongo, Giovanna, Perna, Alessandra, Capasso, Giovambattista, Trepiccione, Francesco, SIMEONI, Mariadelina, Petrillo, Federica, Iervolino, Anna, Zacchia, Miriam, Simeoni, Adelina, Masella, Cristina, Capolongo, Giovanna, Perna, Alessandra, Capasso, Giovambattista, Trepiccione, Francesco, and Simeoni, Mariadelina

Subjects
Regulation of gene expression, Kidney, Dgcr8, biology, DGCR8, The Kidney in Genetic and Rare Diseases: Review, Diabetic nephropathy, Drosha, Pathogenesis, medicine.anatomical_structure, Renal cancer, microRNA, miRNAs, biology.protein, Renal fibrosis, Cancer research, medicine, Renal cystogenesi, Dicer
Abstract

Background: MicroRNAs (miRNAs) are a family of short noncoding RNAs that play important roles in posttranscriptional gene regulation. miRNAs inhibit target gene expression by blocking protein translation or by inducing mRNA degradation and therefore have the potential to modulate physiological and pathological processes. Summary: In the kidney, miRNAs play a role in the organogenesis and in the pathogenesis of several diseases, including renal carcinoma, diabetic nephropathy, cystogenesis, and glomerulopathies. Indeed, podocytes, but also the parietal cells of the Bowman capsule are severely affected by miRNA deregulation. In addition, several miRNAs have been found involved in the development of renal fibrosis. These experimental lines of evidence found a counterpart also in patients affected by diabetic and Ig-A nephropathies, opening the possibility of their use as biomarkers. Finally, the possibility to direct target-specific miRNA to prevent the development of renal fibrosis is encouraging potential novel therapies based on miRNA mimicking or antagonism. This review reports the main studies that investigate the role of miRNAs in the kidneys, in particular highlighting the experimental models used, their potential role as biomarkers and, finally, the most recent data on the miRNA-based therapy. Key Messages: miRNAs are crucial regulators of cell function. They are easy to detect and represent potentially good targets for novel therapies.

Published
2017

42. Corrigendum: Integrin Beta 1 Is Crucial for Urinary Concentrating Ability and Renal Medulla Architecture in Adult Mice

Author

Iervolino, Anna, primary, De La Motte, Luigi R., additional, Petrillo, Federica, additional, Prosperi, Federica, additional, Alvino, Francesca Maria, additional, Schiano, Guglielmo, additional, Perna, Alessandra F., additional, Di Matteo, Danilo, additional, De Felice, Mario, additional, Capasso, Giovambattista, additional, and Trepiccione, Francesco, additional

Published
2018
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43. Integrin Beta 1 Is Crucial for Urinary Concentrating Ability and Renal Medulla Architecture in Adult Mice

Author

Iervolino, Anna, primary, De La Motte, Luigi R., additional, Petrillo, Federica, additional, Prosperi, Federica, additional, Alvino, Francesca Maria, additional, Schiano, Guglielmo, additional, Perna, Alessandra F., additional, Di Matteo, Danilo, additional, De Felice, Mario, additional, Capasso, Giovambattista, additional, and Trepiccione, Francesco, additional

Published
2018
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45. SP011CHARACTERIZATION OF NOVEL MUTATIONS IN ARGININE VASOPRESSIN RECEPTOR 2 GENE (AVRP2) CAUSING NEPHROGENIC DIABETES INSIPIDUS

Author

Prosperi, Federica, primary, Costanzo, Vincenzo, additional, Iervolino, Anna, additional, Petrillo, Federica, additional, De la Motte, Luigi, additional, Marzuillo, Pierluigi, additional, Jelen, Sabina, additional, La Manna, Angela, additional, Capasso, Giovambattista, additional, and Trepiccione, Francesco, additional

Published
2018
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49. NF-B Essential Modulator (NEMO) Is Critical for Thyroid Function

Author

Reale, Carla, Iervolino, Anna, Scudiero, Ivan, Ferravante, Angela, D'Andrea, Luca Egildo, Mazzone, Pellegrino, Zotti, Tiziana, Leonardi, Antonio, Roberto, Luca, Zannini, Mariastella, de Cristofaro, Tiziana, Shanmugakonar, Muralitharan, Capasso, Giovambattista, Pasparakis, Manolis, Vito, Pasquale, Stilo, Romania, Reale, Carla, Iervolino, Anna, Scudiero, Ivan, Ferravante, Angela, D'Andrea, Luca Egildo, Mazzone, Pellegrino, Zotti, Tiziana, Leonardi, Antonio, Roberto, Luca, Zannini, Mariastella, de Cristofaro, Tiziana, Shanmugakonar, Muralitharan, Capasso, Giovambattista, Pasparakis, Manolis, Vito, Pasquale, and Stilo, Romania

Abstract

The I-B kinase (IKK) subunit NEMO/IKK (NEMO) is an adapter molecule that is critical for canonical activation of NF-B, a pleiotropic transcription factor controlling immunity, differentiation, cell growth, tumorigenesis, and apoptosis. To explore the functional role of canonical NF-B signaling in thyroid gland differentiation and function, we have generated a murine strain bearing a genetic deletion of the NEMO locus in thyroid. Here we show that thyrocyte-specific NEMO knock-out mice gradually develop hypothyroidism after birth, which leads to reduced body weight and shortened life span. Histological and molecular analysis indicate that absence of NEMO in thyrocytes results in a dramatic loss of the thyroid gland cellularity, associated with down-regulation of thyroid differentiation markers and ongoing apoptosis. Thus, NEMO-dependent signaling is essential for normal thyroid physiology.

Published
2016

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