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614 results on '"Ierardi, Enzo"'

1. Concomitant and Bismuth Quadruple Therapy for Helicobacter pylori Eradication in Southern Italy: Preliminary Data from a Randomized Clinical Trial

Author

Losurdo, Giuseppe, primary, Borraccino, Antonia Valeria, additional, Aloisio, Adriana, additional, Russo, Francesco, additional, Riezzo, Giuseppe, additional, Galeano, Grazia, additional, Pricci, Maria, additional, Girardi, Bruna, additional, Celiberto, Francesca, additional, Iannone, Andrea, additional, Ierardi, Enzo, additional, and Di Leo, Alfredo, additional

Published
2024
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2. Comparison of Transient Elastography and Point Shear Wave Elastography for Analysis of Liver Stiffness: A Prospective Study

Author

Losurdo, Giuseppe, primary, Ditonno, Ilaria, additional, Novielli, Domenico, additional, Celiberto, Francesca, additional, Iannone, Andrea, additional, Castellaneta, Antonino, additional, Dell’Aquila, Paola, additional, Ranaldo, Nunzio, additional, Rendina, Maria, additional, Barone, Michele, additional, Ierardi, Enzo, additional, and Di Leo, Alfredo, additional

Published
2024
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3. Opioid-induced Constipation: Old and New Concepts in Diagnosis and Treatment.

Author

Squeo, Francesco, Celiberto, Francesca, Ierardi, Enzo, Russo, Francesco, Riezzo, Giuseppe, D'Attoma, Benedetta, Di Leo, Alfredo, and Losurdo, Giuseppe

Subjects
CONSTIPATION, HEALTH facilities, DIAGNOSIS, OPIOID analgesics, LABOR productivity, CANCER pain
Abstract

Daily use of opioid analgesics has significantly increased in recent years due to an increasing prevalence of conditions associated with chronic pain. Opioid-induced constipation (OIC) is one of the most common, under-recognized, and under-treated side effects of opioid analgesics. OIC significantly reduces the quality of life by causing psychological distress, lowering work productivity, and increasing access to healthcare facilities. The economic and social burden of OIC led to the development of precise strategies for daily clinical practice. Key aspects are the prevention of constipation through adequate water intake and fiber support, avoidance of sedentariness, and early recognition and treatment of cofactors that could worsen constipation. Recommended first-line therapy includes osmotic (preferably polyethylene glycol) and stimulant laxatives. Peripherally acting µ-opioid receptor antagonists, such as methylnaltrexone, naloxegol, or naldemedine, should be used in patients that have not responded to the first-line treatments. The bowel functional index is the main tool for assessing the severity of OIC and for monitoring the response. The paper discusses the recent literature on the pathophysiology, clinical evaluation, and management of OIC and provides a pragmatic approach for its assessment and treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Helicobacter pylori Secondary Antibiotic Resistance after One or More Eradication Failure: A Genotypic Stool Analysis Study.

Author

Losurdo, Giuseppe, Mezzapesa, Martino, Ditonno, Ilaria, Piazzolla, Mariapaola, Pricci, Maria, Girardi, Bruna, Celiberto, Francesca, Galeano, Grazia, Riezzo, Giuseppe, Russo, Francesco, Iannone, Andrea, Ierardi, Enzo, and Di Leo, Alfredo

Subjects
DRUG resistance in bacteria, HELICOBACTER pylori, GENOTYPES, BACTERIAL DNA, CLARITHROMYCIN
Abstract

Helicobacter pylori (H. pylori) antibiotic resistance is the leading cause for unsuccessful eradication therapy. After one or more failures, the chance of encountering secondary antibiotic resistance increases. The aim of this study was to characterize genotypic secondary resistance in a cohort of southern Italian H. pylori patients with at least one previous failure. Such patients collected stool samples using a dedicated kit (THD fecal testTM), and bacterial DNA was extracted and amplified using RT-PCR. Resistance to clarithromycin, amoxicillin, metronidazole, levofloxacin, and tetracycline was assessed using a high-resolution melting curve. We enrolled 50 patients. A total of 72% of patients failed one previous antibiotic course, 16% failed two, 10% failed three, and 2% failed four. The rate of secondary antibiotic resistance was 16% for clarithromycin, 18% for metronidazole, 14% for amoxicillin, 14% for levofloxacin, and 2% for tetracycline. Among the eight clarithromycin-resistant patients, five (62.5%) previously received a clarithromycin-based regimen. The same rate was 33.3% (3/9) for metronidazole. The only tetracycline-resistant patient had received Pylera. In conclusion, our data seem to show that, even though secondary resistance is not very high, resistance to clarithromycin could be very likely related to previous exposure to this antibiotic. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Facilitating Self-Directed Learning (SDL) and Satisfaction with SDL among Pre-University Students

Author

Yeoh, Miranda P., Cazan, Ana-Maria, Ierardi, Enzo, and Jacic, Ljubomir A.

Abstract

The aim of the study was to evaluate our practice of self-directed learning (SDL) among pre-university students in Malaysia. Respondents provided data on their previous school learning experiences besides present SDL experiences in college. We carried out exploratory factor analysis based on the school data. We did a confirmatory factor analysis using College SDL experiences of students. Given high similarities between the measurement models, we decided to use the original structure of the instrument. Students provided feedback using a questionnaire based on Prociuk's. A large majority declared that they needed SDL experiences which they lacked while at school. The study also showed that students had rated their SDL experiences in college more positively than in school, on four factors of SDL experiences. Pearson correlations showed that "knowledgeable and organised teachers" and "promotion of active learning" correlated significantly with students' current satisfaction with SDL in college.

Published
2017
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9. Fibres and Colorectal Cancer: Clinical and Molecular Evidence

Author

Celiberto, Francesca, primary, Aloisio, Adriana, additional, Girardi, Bruna, additional, Pricci, Maria, additional, Iannone, Andrea, additional, Russo, Francesco, additional, Riezzo, Giuseppe, additional, D’Attoma, Benedetta, additional, Ierardi, Enzo, additional, Losurdo, Giuseppe, additional, and Di Leo, Alfredo, additional

Published
2023
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20. Familial intestinal polyposis and device assisted enteroscopy: where do we stand?

Author

Losurdo, Giuseppe, Di Leo, Milena, Rizzi, Salvatore, Lacavalla, Ilaria, Celiberto, Francesca, Iannone, Andrea, Rendina, Maria, Ierardi, Enzo, Iabichino, Giuseppe, De Luca, Luca, and Di Leo, Alfredo

Subjects
HEREDITARY nonpolyposis colorectal cancer, ENTEROSCOPY, HEREDITARY cancer syndromes, ADENOMATOUS polyposis coli, POLYPECTOMY, SMALL intestine, MAGNETIC resonance imaging, COLORECTAL cancer, INTESTINES
Abstract

Hereditary polyposis syndromes are a group of inherited disorders associated with a high risk of developing colorectal cancer. The best known ones are familial adenomatous polyposis (FAP), Peutz-Jeghers (PJS), juvenile polyposis and Cowden syndromes, as well as conditions predisposing to cancer, such as Lynch syndrome. Some of them are characterized by an increased risk of small bowel polyps occurrence. Literature search in PubMed was performed in November 2022 and a narrative review was carried out. Since performing small bowel polypectomy is important in such patients, device assisted enteroscopy (DAE) is the key for this procedure. A screening strategy for small bowel polyps is recommended only for PJS. Guidelines endorse either magnetic resonance imaging (MRI) or videocapsule endoscopy (VCE) every 1–3 years, according to the phenotype of the disease. Enteroscopy should be considered for therapeutic purpose in patients with a positive VCE or MRI. DAE has a central role in the resection of polyps larger than mm or causing symptoms of subocclusion or intussusception. Both single (SBE) and double balloon enteroscopy (DBE) are indicated and able to resect polyps up to 6–10 cm. American guidelines have restricted the indications to small bowel enteroscopy only to FAP patients with grade IV Spiegelman. Only some groups of patients (PJS, FAP with demonstrated small bowel polyp burden) may benefit from DAE. [ABSTRACT FROM AUTHOR]

Published
2023
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23. A prospective study on Helicobacter pylori rapid urease test false negativity: is it time for its use in restricted situations?

Author

LOSURDO, Giuseppe, primary, FRANCIOSO, Federica, additional, PRICCI, Maria, additional, GIRARDI, Bruna, additional, RUSSO, Francesco, additional, RIEZZO, Giuseppe, additional, D’ATTOMA, Benedetta, additional, BLEVE, Maria A., additional, IANNONE, Andrea, additional, CELIBERTO, Francesca, additional, IERARDI, Enzo, additional, and DI LEO, Alfredo, additional

Published
2022
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