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1. A Global Survey on Changes in the Supply, Price, and Use of Illicit Drugs and Alcohol, and Related Complications During the 2020 COVID-19 Pandemic

Author

Farhoudian, A, Radfar, S, Ardabili, H, Rafei, P, Ebrahimi, M, Zonoozi, A, De Jong, C, Vahidi, M, Yunesian, M, Kouimtsidis, C, Arunogiri, S, Hansen, H, Brady, K, Potenza, M, Baldacchino, A, Ekhtiari, H, Abagiu, A, Abouna, F, Ahmed, M, Al-Ansari, B, Al-Khair, F, Almaqbali, M, Ambekar, A, Arya, S, Asebikan, V, Ayasreh, M, Basu, D, Benmebarek, Z, Bhad, R, Blaise, M, Bonnet, N, Brasch, J, Broers, B, Busse, A, Butner, J, Camilleri, M, Campello, G, Carra, G, Celic, I, Chalabianloo, F, Chaturvedi, A, Cherpitel, J, Clark, K, Cyders, M, de Bernardis, E, Deilamizade, A, Derry, J, Dhagudu, N, Dolezalova, P, Dom, G, Dunlop, A, Elhabiby, M, Elkholy, H, Essien, N, Farah, G, Ferri, M, Floros, G, Friedman, C, Fuderanan, C, Gerra, G, Ghosh, A, Gogia, M, Grammatikopoulos, I, Grandinetti, P, Guirguis, A, Gutnisky, D, Haber, P, Hassani-Abharian, P, Hooshyari, Z, Ibrahim, I, Ieong, H, Indradewi, R, Iskandar, S, Isra, T, Jain, S, James, S, Javadi, S, Joe, K, Jokubonis, D, Jovanova, A, Kamal, R, Kantchelov, A, Kathiresan, P, Katzman, G, Kawale, P, Kern, A, Kessler, F, Kim, S, Kimball, A, Kljucevic, Z, Kurniasanti, K, Lev, R, Lee, H, Lengvenyte, A, Lev-Ran, S, Mabelya, G, Mahi, M, Maphisa, J, Maremmani, I, Masferrer, L, Massah, O, Mccambridge, O, Mcgovern, G, Min, A, Moghanibashi-Mansourieh, A, Mora-Rios, J, Mudalige, I, Mukherjee, D, Munira, P, Myers, B, Menon, T, Narasimha, V, Ndionuka, N, Nejatisafa, A, Niaz, K, Nizami, A, Nuijens, J, Orsolini, L, Oum, V, Oyemade, A, Palavra, I, Pant, S, Paredes, J, Peyron, E, Quiros, R, Qurishi, R, Rafiq, N, Raghavendra Rao, R, Ratta-Apha, W, Raymond, K, Reimer, J, Renaldo, E, Rezapour, T, Robertson, J, Roncero, C, Roub, F, Rubenstein, E, Rupp, C, Saenz, E, Salehi, M, Samartzis, L, Sarubbo, L, Segrec, N, Shah, B, Shen, H, Shirasaka, T, Shoptaw, S, Sintango, F, Sosa, V, Subata, E, Sztycberg, N, Taghizadeh, F, Wee Teck, J, Tjagvad, C, Torrens, M, Twala, J, Vadivel, R, Volpicelli, J, Weijs, J, Wintoniw, S, Wittayanookulluk, A, Wojnar, M, Yasir, S, Yitayih, Y, Zhao, M, Farhoudian A., Radfar S. R., Ardabili H. M., Rafei P., Ebrahimi M., Zonoozi A. K., De Jong C. A. J., Vahidi M., Yunesian M., Kouimtsidis C., Arunogiri S., Hansen H., Brady K. T., Potenza M. N., Baldacchino A. M., Ekhtiari H., Abagiu A. O., Abouna F. D. N., Ahmed M. H., Al-Ansari B., Al-Khair F. M. A., Almaqbali M. H., Ambekar A., Arya S., Asebikan V. O., Ayasreh M. A., Basu D., Benmebarek Z., Bhad R., Blaise M., Bonnet N., Brasch J., Broers B., Busse A., Butner J. L., Camilleri M., Campello G., Carra G., Celic I., Chalabianloo F., Chaturvedi A., Cherpitel J. J. E. N., Clark K. J., Cyders M. A., de Bernardis E., Deilamizade A., Derry J. E., Dhagudu N. K., Dolezalova P., Dom G., Dunlop A. J., Elhabiby M. M., Elkholy H., Essien N. F., Farah G. I., Ferri M., Floros G. D., Friedman C., Fuderanan C. H., Gerra G., Ghosh A., Gogia M., Grammatikopoulos I. A., Grandinetti P., Guirguis A., Gutnisky D., Haber P. S., Hassani-Abharian P., Hooshyari Z., Ibrahim I. I. M., Ieong H. F. -H., Indradewi R. N., Iskandar S., Isra T. N., Jain S., James S., Javadi S. M. H., Joe K. H., Jokubonis D., Jovanova A. T., Kamal R. M., Kantchelov A. I., Kathiresan P., Katzman G., Kawale P., Kern A. M., Kessler F. H. P., Kim S. -G. S., Kimball A. M., Kljucevic Z., Kurniasanti K. S., Lev R., Lee H. K., Lengvenyte A., Lev-Ran S., Mabelya G. S., Mahi M. A. E., Maphisa J. M., Maremmani I., Masferrer L., Massah O., McCambridge O., McGovern G. G., Min A. K., Moghanibashi-Mansourieh A., Mora-Rios J., Mudalige I. U. K., Mukherjee D., Munira P. M., Myers B., Menon T. N. J., Narasimha V. L., Ndionuka N., Nejatisafa A. -A., Niaz K., Nizami A. T., Nuijens J. H., Orsolini L., Oum V., Oyemade A. A., Palavra I. R., Pant S. B., Paredes J., Peyron E., Quiros R. A., Qurishi R., Rafiq N. U. Z., Raghavendra Rao R., Ratta-Apha W., Raymond K. -L., Reimer J., Renaldo E., Rezapour T., Robertson J. R., Roncero C., Roub F., Rubenstein E. J., Rupp C. I., Saenz E., Salehi M., Samartzis L., Sarubbo L. B., Segrec N., Shah B., Shen H., Shirasaka T., Shoptaw S., Sintango F. M., Sosa V. A., Subata E., Sztycberg N., Taghizadeh F., Wee Teck J. B. T., Tjagvad C., Torrens M., Twala J. M., Vadivel R., Volpicelli J. R., Weijs J., Wintoniw S. M., Wittayanookulluk A., Wojnar M., Yasir S., Yitayih Y., Zhao M., Farhoudian, A, Radfar, S, Ardabili, H, Rafei, P, Ebrahimi, M, Zonoozi, A, De Jong, C, Vahidi, M, Yunesian, M, Kouimtsidis, C, Arunogiri, S, Hansen, H, Brady, K, Potenza, M, Baldacchino, A, Ekhtiari, H, Abagiu, A, Abouna, F, Ahmed, M, Al-Ansari, B, Al-Khair, F, Almaqbali, M, Ambekar, A, Arya, S, Asebikan, V, Ayasreh, M, Basu, D, Benmebarek, Z, Bhad, R, Blaise, M, Bonnet, N, Brasch, J, Broers, B, Busse, A, Butner, J, Camilleri, M, Campello, G, Carra, G, Celic, I, Chalabianloo, F, Chaturvedi, A, Cherpitel, J, Clark, K, Cyders, M, de Bernardis, E, Deilamizade, A, Derry, J, Dhagudu, N, Dolezalova, P, Dom, G, Dunlop, A, Elhabiby, M, Elkholy, H, Essien, N, Farah, G, Ferri, M, Floros, G, Friedman, C, Fuderanan, C, Gerra, G, Ghosh, A, Gogia, M, Grammatikopoulos, I, Grandinetti, P, Guirguis, A, Gutnisky, D, Haber, P, Hassani-Abharian, P, Hooshyari, Z, Ibrahim, I, Ieong, H, Indradewi, R, Iskandar, S, Isra, T, Jain, S, James, S, Javadi, S, Joe, K, Jokubonis, D, Jovanova, A, Kamal, R, Kantchelov, A, Kathiresan, P, Katzman, G, Kawale, P, Kern, A, Kessler, F, Kim, S, Kimball, A, Kljucevic, Z, Kurniasanti, K, Lev, R, Lee, H, Lengvenyte, A, Lev-Ran, S, Mabelya, G, Mahi, M, Maphisa, J, Maremmani, I, Masferrer, L, Massah, O, Mccambridge, O, Mcgovern, G, Min, A, Moghanibashi-Mansourieh, A, Mora-Rios, J, Mudalige, I, Mukherjee, D, Munira, P, Myers, B, Menon, T, Narasimha, V, Ndionuka, N, Nejatisafa, A, Niaz, K, Nizami, A, Nuijens, J, Orsolini, L, Oum, V, Oyemade, A, Palavra, I, Pant, S, Paredes, J, Peyron, E, Quiros, R, Qurishi, R, Rafiq, N, Raghavendra Rao, R, Ratta-Apha, W, Raymond, K, Reimer, J, Renaldo, E, Rezapour, T, Robertson, J, Roncero, C, Roub, F, Rubenstein, E, Rupp, C, Saenz, E, Salehi, M, Samartzis, L, Sarubbo, L, Segrec, N, Shah, B, Shen, H, Shirasaka, T, Shoptaw, S, Sintango, F, Sosa, V, Subata, E, Sztycberg, N, Taghizadeh, F, Wee Teck, J, Tjagvad, C, Torrens, M, Twala, J, Vadivel, R, Volpicelli, J, Weijs, J, Wintoniw, S, Wittayanookulluk, A, Wojnar, M, Yasir, S, Yitayih, Y, Zhao, M, Farhoudian A., Radfar S. R., Ardabili H. M., Rafei P., Ebrahimi M., Zonoozi A. K., De Jong C. A. J., Vahidi M., Yunesian M., Kouimtsidis C., Arunogiri S., Hansen H., Brady K. T., Potenza M. N., Baldacchino A. M., Ekhtiari H., Abagiu A. O., Abouna F. D. N., Ahmed M. H., Al-Ansari B., Al-Khair F. M. A., Almaqbali M. H., Ambekar A., Arya S., Asebikan V. O., Ayasreh M. A., Basu D., Benmebarek Z., Bhad R., Blaise M., Bonnet N., Brasch J., Broers B., Busse A., Butner J. L., Camilleri M., Campello G., Carra G., Celic I., Chalabianloo F., Chaturvedi A., Cherpitel J. J. E. N., Clark K. J., Cyders M. A., de Bernardis E., Deilamizade A., Derry J. E., Dhagudu N. K., Dolezalova P., Dom G., Dunlop A. J., Elhabiby M. M., Elkholy H., Essien N. F., Farah G. I., Ferri M., Floros G. D., Friedman C., Fuderanan C. H., Gerra G., Ghosh A., Gogia M., Grammatikopoulos I. A., Grandinetti P., Guirguis A., Gutnisky D., Haber P. S., Hassani-Abharian P., Hooshyari Z., Ibrahim I. I. M., Ieong H. F. -H., Indradewi R. N., Iskandar S., Isra T. N., Jain S., James S., Javadi S. M. H., Joe K. H., Jokubonis D., Jovanova A. T., Kamal R. M., Kantchelov A. I., Kathiresan P., Katzman G., Kawale P., Kern A. M., Kessler F. H. P., Kim S. -G. S., Kimball A. M., Kljucevic Z., Kurniasanti K. S., Lev R., Lee H. K., Lengvenyte A., Lev-Ran S., Mabelya G. S., Mahi M. A. E., Maphisa J. M., Maremmani I., Masferrer L., Massah O., McCambridge O., McGovern G. G., Min A. K., Moghanibashi-Mansourieh A., Mora-Rios J., Mudalige I. U. K., Mukherjee D., Munira P. M., Myers B., Menon T. N. J., Narasimha V. L., Ndionuka N., Nejatisafa A. -A., Niaz K., Nizami A. T., Nuijens J. H., Orsolini L., Oum V., Oyemade A. A., Palavra I. R., Pant S. B., Paredes J., Peyron E., Quiros R. A., Qurishi R., Rafiq N. U. Z., Raghavendra Rao R., Ratta-Apha W., Raymond K. -L., Reimer J., Renaldo E., Rezapour T., Robertson J. R., Roncero C., Roub F., Rubenstein E. J., Rupp C. I., Saenz E., Salehi M., Samartzis L., Sarubbo L. B., Segrec N., Shah B., Shen H., Shirasaka T., Shoptaw S., Sintango F. M., Sosa V. A., Subata E., Sztycberg N., Taghizadeh F., Wee Teck J. B. T., Tjagvad C., Torrens M., Twala J. M., Vadivel R., Volpicelli J. R., Weijs J., Wintoniw S. M., Wittayanookulluk A., Wojnar M., Yasir S., Yitayih Y., and Zhao M.

Abstract

Background and Aims: COVID-19 has infected more than 77 million people worldwide and impacted the lives of many more, with a particularly devastating impact on vulnerable populations, including people with substance use disorders (SUDs). Quarantines, travel bans, regulatory changes, social distancing, and “lockdown” measures have affected drug and alcohol supply chains and subsequently their availability, price, and use patterns, with possible downstream effects on presentations of SUDs and demand for treatment. Given the lack of multicentric epidemiologic studies, we conducted a rapid global survey within the International Society of Addiction Medicine (ISAM) network in order to understand the status of substance-use patterns during the current pandemic. Design: Cross-sectional survey. Setting: Worldwide. Participants: Starting on April 4, 2020 during a 5-week period, the survey received 185 responses from 77 countries. Measurements: To assess addiction medicine professionals' perceived changes in drug and alcohol supply, price, use pattern, and related complications during the COVID-19 pandemic. Findings: Participants reported (among who answered “decreased” or “increased”) a decrease in drug supply (69.0%) and at the same time an increase in price (95.3%) globally. With respect to changes in use patterns, an increase in alcohol (71.7%), cannabis (63.0%), prescription opioids (70.9%), and sedative/hypnotics (84.6%) use was reported, while the use of amphetamines (59.7%), cocaine (67.5%), and opiates (58.2%) was reported to decrease overall. Conclusions: The global report on changes in the availability, use patterns, and complications of alcohol and drugs during the COVID-19 pandemic should be considered in making new policies and in developing mitigating measures and guidelines during the current pandemic (and probable future ones) in order to minimize risks to people with SUD.

Published
2021

2. Reorganization of Substance Use Treatment and Harm Reduction Services During the COVID-19 Pandemic: A Global Survey

Author

Radfar, S, De Jong, C, Farhoudian, A, Ebrahimi, M, Rafei, P, Vahidi, M, Yunesian, M, Kouimtsidis, C, Arunogiri, S, Massah, O, Deylamizadeh, A, Brady, K, Busse, A, Potenza, M, Ekhtiari, H, Baldacchino, A, Abagiu, A, Abouna, F, Ahmed, M, Al-ansari, B, Mahmmoud Abu Al-khair, F, Almaqbali, M, Ambekar, A, Ardabili, H, Arya, S, Lasebikan, V, Ayasreh, M, Basu, D, Benmebarek, Z, Bhad, R, Blaise, M, Bonnet, N, Brasch, J, Broers, B, Butner, J, Camilleri, M, Campello, G, Carra, G, Celic, I, Chalabianloo, F, Chaturvedi, A, de Jesus Eduardo Noyola Cherpitel, J, Clark, K, Cyders, M, de Bernardis, E, Derry, J, Dhagudu, N, Dolezalova, P, Dom, G, Dunlop, A, Elhabiby, M, Elkholy, H, Essien, N, Farah, G, Ferri, M, Floros, G, Friedman, C, Fuderanan, C, Gerra, G, Ghosh, A, Gogia, M, Grammatikopoulos, I, Grandinetti, P, Guirguis, A, Gutnisky, D, Haber, P, Hassani-Abharian, P, Hooshyari, Z, Ibrahim, I, Ieong, H, Indradewi, R, Iskandar, S, Jain, S, James, S, Javadi, S, Joe, K, Jokubonis, D, Jovanova, A, Kamal, R, Kantchelov, A, Kathiresan, P, Katzman, G, Kawale, P, Kern, A, Kessler, F, Kim, S, Kimball, A, Kljucevic, Z, Siste, K, Lev, R, Lee, H, Lengvenyte, A, Lev-ran, S, Mabelya, G, Mahi, M, Maphisa, J, Maremmani, I, Masferrer, L, Mccambridge, O, Mcgovern, G, Min, A, Moghanibashi-Mansourieh, A, Mora-Rios, J, Mudalige, I, Mukherjee, D, Munira, P, Myers, B, Menon T N, J, Narasimha, V, Ndionuka, N, Nejatisafa, A, Niaz, K, Nizami, A, Nuijens, J, Orsolini, L, Oum, V, Oyemade, A, Palavra, I, Pant, S, Paredes, J, Peyron, E, Alberto Quiros, R, Qurishi, R, Rafiq, N, Rao, R, Ratta-apha, W, Raymond, K, Reimer, J, Renaldo, E, Rezapour, T, Robertson, J, Roncero, C, Roub, F, Rubenstein, E, Rupp, C, Saenz, E, Salehi, M, Samartzis, L, Sarubbo, L, Segrec, N, Shah, B, Shen, H, Shirasaka, T, Shoptaw, S, Sintango, F, Sosa, V, Subata, E, Sztycberg, N, Taghizadeh, F, Teck, J, Tjagvad, C, Torrens, M, Twala, J, Vadivel, R, Volpicelli, J, Weijs, J, Wintoniw, S, Wittayanookulluk, A, Wojnar, M, Yasir, S, Yitayih, Y, Zhao, M, Zonoozi, A, Radfar S. R., De Jong C. A. J., Farhoudian A., Ebrahimi M., Rafei P., Vahidi M., Yunesian M., Kouimtsidis C., Arunogiri S., Massah O., Deylamizadeh A., Brady K. T., Busse A., Potenza M. N., Ekhtiari H., Baldacchino A. M., Abagiu A. O., Abouna F. D. N., Ahmed M. H., Al-ansari B., Mahmmoud Abu Al-khair F., Almaqbali M. H., Ambekar A., Ardabili H. M., Arya S., Lasebikan V. O., Ayasreh M. A., Basu D., Benmebarek Z., Bhad R., Blaise M., Bonnet N., Brasch J., Broers B., Butner J. L., Camilleri M., Campello G., Carra G., Celic I., Chalabianloo F., Chaturvedi A., de Jesus Eduardo Noyola Cherpitel J., Clark K. J., Cyders M. A., de Bernardis E., Derry J. E., Dhagudu N. K., Dolezalova P., Dom G., Dunlop A. J., Elhabiby M. M., Elkholy H., Essien N. F., Farah G. I., Ferri M., Floros G. D., Friedman C., Fuderanan C. H., Gerra G., Ghosh A., Gogia M., Grammatikopoulos I. A., Grandinetti P., Guirguis A., Gutnisky D., Haber P. S., Hassani-Abharian P., Hooshyari Z., Ibrahim I. I. M., Ieong H., Indradewi R. N., Iskandar S., Jain S., James S., Javadi S. M. H., Joe K. H., Jokubonis D., Jovanova A. T., Kamal R. M., Kantchelov A. I., Kathiresan P., Katzman G., Kawale P., Kern A. M., Kessler F. H. P., Kim S., Kimball A. M., Kljucevic Z., Siste K., Lev R., Lee H. K., Lengvenyte A., Lev-ran S., Mabelya G. S., Mahi M. A. E., Maphisa J., Maremmani I., Masferrer L., McCambridge O., McGovern G. G., Min A. K., Moghanibashi-Mansourieh A., Mora-Rios J., Mudalige I. U. K., Mukherjee D., Munira P. M., Myers B., Menon T N J., Narasimha V. L., Ndionuka N., Nejatisafa A., Niaz K., Nizami A. T., Nuijens J. H., Orsolini L., Oum V., Oyemade A. A., Palavra I. R., Pant S. B., Paredes J., Peyron E., Alberto Quiros R., Qurishi R., Rafiq N. U. Z., Rao R. R., Ratta-apha W., Raymond K., Reimer J., Renaldo E., Rezapour T., Robertson J. R., Roncero C., Roub F., Rubenstein E. J., Rupp C. I., Saenz E., Salehi M., Samartzis L., Sarubbo L. B., Segrec N., Shah B., Shen H., Shirasaka T., Shoptaw S., Sintango F. M., Sosa V. A., Subata E., Sztycberg N., Taghizadeh F., Teck J., Tjagvad C., Torrens M., Twala J. M., Vadivel R., Volpicelli J. R., Weijs J., Wintoniw S. M., Wittayanookulluk A., Wojnar M., Yasir S., Yitayih Y., Zhao M., Zonoozi A. K., Radfar, S, De Jong, C, Farhoudian, A, Ebrahimi, M, Rafei, P, Vahidi, M, Yunesian, M, Kouimtsidis, C, Arunogiri, S, Massah, O, Deylamizadeh, A, Brady, K, Busse, A, Potenza, M, Ekhtiari, H, Baldacchino, A, Abagiu, A, Abouna, F, Ahmed, M, Al-ansari, B, Mahmmoud Abu Al-khair, F, Almaqbali, M, Ambekar, A, Ardabili, H, Arya, S, Lasebikan, V, Ayasreh, M, Basu, D, Benmebarek, Z, Bhad, R, Blaise, M, Bonnet, N, Brasch, J, Broers, B, Butner, J, Camilleri, M, Campello, G, Carra, G, Celic, I, Chalabianloo, F, Chaturvedi, A, de Jesus Eduardo Noyola Cherpitel, J, Clark, K, Cyders, M, de Bernardis, E, Derry, J, Dhagudu, N, Dolezalova, P, Dom, G, Dunlop, A, Elhabiby, M, Elkholy, H, Essien, N, Farah, G, Ferri, M, Floros, G, Friedman, C, Fuderanan, C, Gerra, G, Ghosh, A, Gogia, M, Grammatikopoulos, I, Grandinetti, P, Guirguis, A, Gutnisky, D, Haber, P, Hassani-Abharian, P, Hooshyari, Z, Ibrahim, I, Ieong, H, Indradewi, R, Iskandar, S, Jain, S, James, S, Javadi, S, Joe, K, Jokubonis, D, Jovanova, A, Kamal, R, Kantchelov, A, Kathiresan, P, Katzman, G, Kawale, P, Kern, A, Kessler, F, Kim, S, Kimball, A, Kljucevic, Z, Siste, K, Lev, R, Lee, H, Lengvenyte, A, Lev-ran, S, Mabelya, G, Mahi, M, Maphisa, J, Maremmani, I, Masferrer, L, Mccambridge, O, Mcgovern, G, Min, A, Moghanibashi-Mansourieh, A, Mora-Rios, J, Mudalige, I, Mukherjee, D, Munira, P, Myers, B, Menon T N, J, Narasimha, V, Ndionuka, N, Nejatisafa, A, Niaz, K, Nizami, A, Nuijens, J, Orsolini, L, Oum, V, Oyemade, A, Palavra, I, Pant, S, Paredes, J, Peyron, E, Alberto Quiros, R, Qurishi, R, Rafiq, N, Rao, R, Ratta-apha, W, Raymond, K, Reimer, J, Renaldo, E, Rezapour, T, Robertson, J, Roncero, C, Roub, F, Rubenstein, E, Rupp, C, Saenz, E, Salehi, M, Samartzis, L, Sarubbo, L, Segrec, N, Shah, B, Shen, H, Shirasaka, T, Shoptaw, S, Sintango, F, Sosa, V, Subata, E, Sztycberg, N, Taghizadeh, F, Teck, J, Tjagvad, C, Torrens, M, Twala, J, Vadivel, R, Volpicelli, J, Weijs, J, Wintoniw, S, Wittayanookulluk, A, Wojnar, M, Yasir, S, Yitayih, Y, Zhao, M, Zonoozi, A, Radfar S. R., De Jong C. A. J., Farhoudian A., Ebrahimi M., Rafei P., Vahidi M., Yunesian M., Kouimtsidis C., Arunogiri S., Massah O., Deylamizadeh A., Brady K. T., Busse A., Potenza M. N., Ekhtiari H., Baldacchino A. M., Abagiu A. O., Abouna F. D. N., Ahmed M. H., Al-ansari B., Mahmmoud Abu Al-khair F., Almaqbali M. H., Ambekar A., Ardabili H. M., Arya S., Lasebikan V. O., Ayasreh M. A., Basu D., Benmebarek Z., Bhad R., Blaise M., Bonnet N., Brasch J., Broers B., Butner J. L., Camilleri M., Campello G., Carra G., Celic I., Chalabianloo F., Chaturvedi A., de Jesus Eduardo Noyola Cherpitel J., Clark K. J., Cyders M. A., de Bernardis E., Derry J. E., Dhagudu N. K., Dolezalova P., Dom G., Dunlop A. J., Elhabiby M. M., Elkholy H., Essien N. F., Farah G. I., Ferri M., Floros G. D., Friedman C., Fuderanan C. H., Gerra G., Ghosh A., Gogia M., Grammatikopoulos I. A., Grandinetti P., Guirguis A., Gutnisky D., Haber P. S., Hassani-Abharian P., Hooshyari Z., Ibrahim I. I. M., Ieong H., Indradewi R. N., Iskandar S., Jain S., James S., Javadi S. M. H., Joe K. H., Jokubonis D., Jovanova A. T., Kamal R. M., Kantchelov A. I., Kathiresan P., Katzman G., Kawale P., Kern A. M., Kessler F. H. P., Kim S., Kimball A. M., Kljucevic Z., Siste K., Lev R., Lee H. K., Lengvenyte A., Lev-ran S., Mabelya G. S., Mahi M. A. E., Maphisa J., Maremmani I., Masferrer L., McCambridge O., McGovern G. G., Min A. K., Moghanibashi-Mansourieh A., Mora-Rios J., Mudalige I. U. K., Mukherjee D., Munira P. M., Myers B., Menon T N J., Narasimha V. L., Ndionuka N., Nejatisafa A., Niaz K., Nizami A. T., Nuijens J. H., Orsolini L., Oum V., Oyemade A. A., Palavra I. R., Pant S. B., Paredes J., Peyron E., Alberto Quiros R., Qurishi R., Rafiq N. U. Z., Rao R. R., Ratta-apha W., Raymond K., Reimer J., Renaldo E., Rezapour T., Robertson J. R., Roncero C., Roub F., Rubenstein E. J., Rupp C. I., Saenz E., Salehi M., Samartzis L., Sarubbo L. B., Segrec N., Shah B., Shen H., Shirasaka T., Shoptaw S., Sintango F. M., Sosa V. A., Subata E., Sztycberg N., Taghizadeh F., Teck J., Tjagvad C., Torrens M., Twala J. M., Vadivel R., Volpicelli J. R., Weijs J., Wintoniw S. M., Wittayanookulluk A., Wojnar M., Yasir S., Yitayih Y., Zhao M., and Zonoozi A. K.

Abstract

Background: The coronavirus disease 2019 (COVID-19) pandemic has impacted people with substance use disorders (SUDs) worldwide, and healthcare systems have reorganized their services in response to the pandemic. Methods: One week after the announcement of the COVID-19 as a pandemic, in a global survey, 177 addiction medicine professionals described COVID-19-related health responses in their own 77 countries in terms of SUD treatment and harm reduction services. The health responses were categorized around (1) managerial measures and systems, (2) logistics, (3) service providers, and (4) vulnerable groups. Results: Respondents from over 88% of countries reported that core medical and psychiatric care for SUDs had continued; however, only 56% of countries reported having had any business continuity plan, and 37.5% of countries reported shortages of methadone or buprenorphine supplies. Participants of 41% of countries reported partial discontinuation of harm-reduction services such as needle and syringe programs and condom distribution. Fifty-seven percent of overdose prevention interventions and 81% of outreach services were also negatively impacted. Conclusions: Participants reported that SUD treatment and harm-reduction services had been significantly impacted globally early during the COVID-19 pandemic. Based on our findings, we highlight several issues and complications resulting from the pandemic concerning people with SUDs that should be tackled more efficiently during the future waves or similar pandemics. The issues and potential strategies comprise the following: (1) helping policymakers to generate business continuity plans, (2) maintaining the use of evidence-based interventions for people with SUDs, (3) being prepared for adequate medication supplies, (4) integrating harm reduction programs with other treatment modalities, and (5) having specific considerations for vulnerable groups such as immigrants and refugees.

Published
2021

3. Membrane mirrors modulate light

Author

Warde, Cardinal and Ieong, H.-H.

Subjects
Business, Electronics and electrical industries
Abstract

In combination with spatial filters, deformable membrane mirrors can serve either as light shutters or two-dimensional spatial light modulators. Membrane-mirror light-modulator (MLM) technology has been in existence at least since [...]

Published
2001

6. Reorganization of Substance Use Treatment and Harm Reduction Services During the COVID-19 Pandemic: A Global Survey

Author

Seyed Ramin Radfar, Cornelis A. J. De Jong, Ali Farhoudian, Mohsen Ebrahimi, Parnian Rafei, Mehrnoosh Vahidi, Masud Yunesian, Christos Kouimtsidis, Shalini Arunogiri, Omid Massah, Abbas Deylamizadeh, Kathleen T. Brady, Anja Busse, ISAM-PPIG Global Survey Consortium, Marc N. Potenza, Hamed Ekhtiari, Alexander Mario Baldacchino, Adrian Octavian Abagiu, Franck David Noel Abouna, Mohamed Hassan Ahmed, Basma Al-ansari, Feda Mahmmoud Abu Al-khair, Mandhar Humaid Almaqbali, Atul Ambekar, Hossein Mohaddes Ardabili, Sidharth Arya, Victor Olufolahan Lasebikan, Murad Ali Ayasreh, Debasish Basu, Zoubir Benmebarek, Roshan Bhad, Mario Blaise, Nicolas Bonnet, Jennifer Brasch, Barbara Broers, Jenna L. Butner, Moses Camilleri, Giovanna Campello, Giuseppe Carra, Ivan Celic, Fatemeh Chalabianloo, Abhishek Chaturvedi, José de Jesús Eduardo Noyola Cherpitel, Kelly J. Clark, Melissa Anne Cyders, Ernesto de Bernardis, John Edward Derry, Naveen Kumar Dhagudu, Pavla Dolezalova, Geert Dom, Adrian John Dunlop, Mahmoud Mamdouh Elhabiby, Hussien Elkholy, Nsidibe Francis Essien, Ghandi Ilias Farah, Marica Ferri, Georgios D Floros, Catherine Friedman, Clara Hidalgo Fuderanan, Gilberto Gerra, Abhishek Ghosh, Maka Gogia, Ilias A. Grammatikopoulos, Paolo Grandinetti, Amira Guirguis, David Gutnisky, Paul Steven Haber, Peyman Hassani-Abharian, Zahra Hooshyari, Islam Ibrahim Mokhtar Ibrahim, Hada Fong-ha Ieong, Regina Nova Indradewi, Shelly Iskandar, Shobhit Jain, Sandi James, Seyyed Mohammad hossein Javadi, Keun Ho Joe, Darius Jokubonis, Acka Tushevska Jovanova, Rama Mohamed Kamal, Alexander Ivanov Kantchelov, Preethy Kathiresan, Gary Katzman, Paul Kawale, Audrey Margaret Kern, Felix Henrique Paim Kessler, Sung-Gon Sue Kim, Ann Marie Kimball, Zeljko Kljucevic, Kristiana Siste, Roneet Lev, Hae Kook Lee, Aiste Lengvenyte, Shaul Lev-ran, Geni Seseja Mabelya, Mohamed Ali El Mahi, J. Maphisa Maphisa, Icro Maremmani, Laura Masferrer, Orlagh McCambridge, Garrett Gregory McGovern, Aung Kyi Min, Amir Moghanibashi-Mansourieh, Jazman Mora-Rios, Indika Udaya Kumara Mudalige, Diptadhi Mukherjee, Pejic Munira Munira, Bronwyn Myers, Jayakrishnan Menon T N, Venkata Lakshmi Narasimha, Nkemakolam Ndionuka, Ali-Akbar Nejatisafa, Kamran Niaz, Asad Tamizuddin Nizami, Jan H. Nuijens, Laura Orsolini, Vantheara Oum, Adegboyega Adekunle Oyemade, Irena Rojnia Palavra, Sagun Ballav Pant, Joselyn Paredes, Eric Peyron, Randall Alberto Quirós, Rouhollah Qurishi, Noor ul Zaman Rafiq, Ranjini Raghavendra Rao, Woraphat Ratta-apha, Karren-Lee Raymond, Jens Reimer, Eduardo Renaldo, Tara Rezapour, James Roy Robertson, Carlos Roncero, Fazle Roub, Elizabeth Jane Rubenstein, Claudia Ines Rupp, Elizabeth Saenz, Mohammad Salehi, Lampros Samartzis, Laura Beatriz Sarubbo, Nusa Segrec, Bigya Shah, Hongxian Shen, Tomohiro Shirasaka, Steve Shoptaw, Fransiskus Muronga Sintango, Veronica Andrea Sosa, Emilis Subata, Norberto Sztycberg, Fatemeh Taghizadeh, Joseph Brian Tay Wee Teck, Christian Tjagvad, Marta Torrens, Judith Meme Twala, Ramyadarshni Vadivel, Joseph Robert Volpicelli, Jelmer Weijs, Steven Michael Wintoniw, Apisak Wittayanookulluk, Marcin Wojnar, Sadia Yasir, Yimenu Yitayih, Min Zhao, Arash Khojasteh Zonoozi, ISAM-PPIG Global Survey Consortium, Radfar, S, De Jong, C, Farhoudian, A, Ebrahimi, M, Rafei, P, Vahidi, M, Yunesian, M, Kouimtsidis, C, Arunogiri, S, Massah, O, Deylamizadeh, A, Brady, K, Busse, A, Potenza, M, Ekhtiari, H, Baldacchino, A, Abagiu, A, Abouna, F, Ahmed, M, Al-ansari, B, Mahmmoud Abu Al-khair, F, Almaqbali, M, Ambekar, A, Ardabili, H, Arya, S, Lasebikan, V, Ayasreh, M, Basu, D, Benmebarek, Z, Bhad, R, Blaise, M, Bonnet, N, Brasch, J, Broers, B, Butner, J, Camilleri, M, Campello, G, Carra, G, Celic, I, Chalabianloo, F, Chaturvedi, A, de Jesus Eduardo Noyola Cherpitel, J, Clark, K, Cyders, M, de Bernardis, E, Derry, J, Dhagudu, N, Dolezalova, P, Dom, G, Dunlop, A, Elhabiby, M, Elkholy, H, Essien, N, Farah, G, Ferri, M, Floros, G, Friedman, C, Fuderanan, C, Gerra, G, Ghosh, A, Gogia, M, Grammatikopoulos, I, Grandinetti, P, Guirguis, A, Gutnisky, D, Haber, P, Hassani-Abharian, P, Hooshyari, Z, Ibrahim, I, Ieong, H, Indradewi, R, Iskandar, S, Jain, S, James, S, Javadi, S, Joe, K, Jokubonis, D, Jovanova, A, Kamal, R, Kantchelov, A, Kathiresan, P, Katzman, G, Kawale, P, Kern, A, Kessler, F, Kim, S, Kimball, A, Kljucevic, Z, Siste, K, Lev, R, Lee, H, Lengvenyte, A, Lev-ran, S, Mabelya, G, Mahi, M, Maphisa, J, Maremmani, I, Masferrer, L, Mccambridge, O, Mcgovern, G, Min, A, Moghanibashi-Mansourieh, A, Mora-Rios, J, Mudalige, I, Mukherjee, D, Munira, P, Myers, B, Menon T N, J, Narasimha, V, Ndionuka, N, Nejatisafa, A, Niaz, K, Nizami, A, Nuijens, J, Orsolini, L, Oum, V, Oyemade, A, Palavra, I, Pant, S, Paredes, J, Peyron, E, Alberto Quiros, R, Qurishi, R, Rafiq, N, Rao, R, Ratta-apha, W, Raymond, K, Reimer, J, Renaldo, E, Rezapour, T, Robertson, J, Roncero, C, Roub, F, Rubenstein, E, Rupp, C, Saenz, E, Salehi, M, Samartzis, L, Sarubbo, L, Segrec, N, Shah, B, Shen, H, Shirasaka, T, Shoptaw, S, Sintango, F, Sosa, V, Subata, E, Sztycberg, N, Taghizadeh, F, Teck, J, Tjagvad, C, Torrens, M, Twala, J, Vadivel, R, Volpicelli, J, Weijs, J, Wintoniw, S, Wittayanookulluk, A, Wojnar, M, Yasir, S, Yitayih, Y, Zhao, M, Zonoozi, A, University of St Andrews. School of Medicine, University of St Andrews. Centre for Minorities Research (CMR), and University of St Andrews. Population and Behavioural Science Division

Subjects
opioid agonist treatment, RC435-571, Psychological intervention, addiction services, Health administration, Experimental Psychopathology and Treatment, 0302 clinical medicine, RA0421, RA0421 Public health. Hygiene. Preventive Medicine, Pandemic, Severe acute respiratory syndrome coronavirus 2, Drug addiction, 030212 general & internal medicine, harm reduction, Original Research, Psychiatry, Public health, Addiction medicine, substance use disorder, public health, 3rd-DAS, Opiate agonist treatment, Addiction services, Outreach, Substance abuse, Psychiatry and Mental health, RM, COVID-19 pandemic, drug policy, medicine.medical_specialty, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Drug policy, medicine, Substance use disorders, Harm reduction, business.industry, SDG 16 - Peace, Justice and Strong Institutions, COVID-19, medicine.disease, addiction service, RM Therapeutics. Pharmacology, Coronavirus, Family medicine, Human medicine, business, 030217 neurology & neurosurgery
Abstract

Background:The coronavirus disease 2019 (COVID-19) pandemic has impacted people with substance use disorders (SUDs) worldwide, and healthcare systems have reorganized their services in response to the pandemic.Methods:One week after the announcement of the COVID-19 as a pandemic, in a global survey, 177 addiction medicine professionals described COVID-19-related health responses in their own 77 countries in terms of SUD treatment and harm reduction services. The health responses were categorized around (1) managerial measures and systems, (2) logistics, (3) service providers, and (4) vulnerable groups.Results:Respondents from over 88% of countries reported that core medical and psychiatric care for SUDs had continued; however, only 56% of countries reported having had any business continuity plan, and 37.5% of countries reported shortages of methadone or buprenorphine supplies. Participants of 41% of countries reported partial discontinuation of harm-reduction services such as needle and syringe programs and condom distribution. Fifty-seven percent of overdose prevention interventions and 81% of outreach services were also negatively impacted.Conclusions:Participants reported that SUD treatment and harm-reduction services had been significantly impacted globally early during the COVID-19 pandemic. Based on our findings, we highlight several issues and complications resulting from the pandemic concerning people with SUDs that should be tackled more efficiently during the future waves or similar pandemics. The issues and potential strategies comprise the following: (1) helping policymakers to generate business continuity plans, (2) maintaining the use of evidence-based interventions for people with SUDs, (3) being prepared for adequate medication supplies, (4) integrating harm reduction programs with other treatment modalities, and (5) having specific considerations for vulnerable groups such as immigrants and refugees.

Published
2021

7. Punctate Administration of Ficin as a human and animal model of non-histaminergic itch.

Author

Malewicz NM, Ieong HF, Oeck S, Kumowski N, Zhang Z, Shimada SG, and LaMotte RH

Subjects
Animals, Disease Models, Animal, Histamine, Humans, Mice, Pain, Ficain, Pruritus chemically induced
Abstract

Background: Ficin, a cysteine protease derived from fig-tree latex, has been reported to elicit itch and nociceptive sensations, though quantitative sensory studies are lacking. Cowhage containing the pruritic cysteine Mucunain, on the contrary, has been widely studied as activating polymodal nociceptors and eliciting a histamine-independent itch., Objectives: We tested whether ficin in heat-inactivated cowhage spicules would elicit itch and nociceptive sensations in humans, and analogous behaviours in mice, which are similar to those evoked by native cowhage, and whether these behaviours in mice were dose-dependent when ficin was injected intradermally., Methods: Human volunteers rated the magnitude of itch and nociceptive sensations evoked by either native cowhage spicules or heat-inactivated spicules soaked in 1, 10 or 100 mg/mL ficin (0.03, 0.3 and 3 ng of ficin in spicule tip), applied to forearm. In mice, itch-like scratching and nociceptive-like wiping were recorded in response to either native cowhage, to heat-inactivated spicules that were either inactive or contained 100 mg/mL ficin, or to intradermal injections of 1.25, 2.5 or 5 μg/ 5 μL, each treatment applied to the cheek., Results: The dose of 100 mg/mL ficin in spicules evoked comparable magnitudes of itch, nociceptive sensations and areas of cutaneous dysesthesia as native cowhage in humans and comparable itch-like scratching and pain-like wiping behaviours in mice. But to elicit similar behaviours when injected intradermally in mice a greater amount of ficin (1.25 μg) was required., Conclusion: Spicule delivery or intradermal injection of ficin elicits behaviours in mice that model itch and nociceptive sensations in humans, suggesting that ficin may be useful in translating mechanistic research on the neural mechanisms of pruritic and nociceptive effects of cysteine proteases between the two species., (© 2022 European Academy of Dermatology and Venereology.)

Published
2022
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