Search

Your search keyword '"Ienaga K"' showing total 181 results
Start Over Author "Ienaga K"
181 results on '"Ienaga K"'

13. Chemistry of Crosslines

Author

Nakamura, K., primary, Hochi, T., additional, Nakazawa, Y., additional, Fukunaga, Y., additional, and Ienaga, K., additional

Published
2005
Full Text
View/download PDF

28. Serum accumulation of a creatinine oxidative metabolite (NZ-419: 5-hydroxy-1- methylhydatoin) as an intrinsic antioxidant in diabetic patients with or without chronic kidney disease

Author

Ienaga K, Nakano K, and Goji Hasegawa

Subjects
Adult, Male, medicine.medical_specialty, Antioxidant, medicine.medical_treatment, Metabolite, Oxidative phosphorylation, Antioxidants, chemistry.chemical_compound, Molar ratio, Internal medicine, Diabetes mellitus, medicine, Humans, Diabetic Nephropathies, Creatinine, business.industry, Hydantoins, General Medicine, Middle Aged, medicine.disease, Endocrinology, chemistry, Biochemistry, Nephrology, Chronic renal failure, Kidney Failure, Chronic, Female, business, Kidney disease
Abstract

AIMS In mammals, creatinine (Cr) is catabolized by a dual oxidative pathway via 5-hydroxy-1-methylhydantoin or 5-hydroxycreatinine. The former, an intrinsic antioxidant, termed NZ-419, has been reported to prevent the progression of chronic renal failure in animal models. However, its clinical intrinsic serum level has not yet been reported. METHODS We analyzed serum NZ-419 levels in diabetic and nondiabetic patients with or without Stage 3 - 5 chronic kidney disease (CKD). RESULTS The levels of NZ-419 in diabetic patients with (88.1 ± 17.2 µg/dl, p < 0.001) or without (31.5 ± 2.4 µg/dl, p < 0.05) Stage 3 - 5 CKD were significantly higher than in nondiabetic normal controls (9.0 ± 5.6 µg/dl). The molar ratio data showed NZ-419/Cr was significantly higher in both diabetic patients with (p < 0.01) or without Stage 3 - 5 CKD (p < 0.001) compared to nondiabetic normal controls. No further increase occurred with increasing severity of renal failure. Furthermore, nondiabetic patients with or without Stage 3 - 5 CKD did not show significantly different molar ratio values than controls but had significantly higher values of NZ-419 levels (p < 0.001). CONCLUSIONS Overproduction and decreased clearance played a major role in the increased NZ-419 levels we observed in the patients with diabetes and Stage 3 - 5 CKD, respectively. The existence of chronic renal failure did not further enhance this overproduction.

Published
2011

42. A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats.

Author

Nakamura, J, primary, Kato, K, additional, Hamada, Y, additional, Nakayama, M, additional, Chaya, S, additional, Nakashima, E, additional, Naruse, K, additional, Kasuya, Y, additional, Mizubayashi, R, additional, Miwa, K, additional, Yasuda, Y, additional, Kamiya, H, additional, Ienaga, K, additional, Sakakibara, F, additional, Koh, N, additional, and Hotta, N, additional

Published
1999
Full Text
View/download PDF

43. Immunochemical quantification of crossline as a fluorescent advanced glycation endproduct in erythrocyte membrane proteins from diabetic patients with or without retinopathy

Author

Yamaguchi, M., primary, Nakamura, N., additional, Nakano, K., additional, Kitagawa, Y., additional, Shigeta, H., additional, Hasegawa, G., additional, Ienaga, K., additional, Nakamura, K., additional, Nakazawa, Y., additional, Fukui, I., additional, Obayashi, H., additional, and Kondo, M., additional

Published
1998
Full Text
View/download PDF

49. The Dimroth rearrangement. XVII. The rearrangement of some 1,6-Dihydro-6-imino-1,2-polymethylenepyrimidines into 2,N6-polymethylene-bridged 6-aminopyrimidines

Author

Brown, DJ and Ienaga, K

Abstract

The cyclic imino ether, 2-ethoxy-3,4,5,6,7,8-hexahydroazocine (4; n = 6), condenses with amino-methylenemalononitrile (3; R = CN) to give the bicyclic imine, 6,7,8,9,10,11-hexahydro-4-imino-4H-pyrimido[1,2- alazocine-3-carbonitrile (5f), which undergoes Dimroth rearrangement in boiling butanol to yield a β-bridged isomer, 2,10,13- triazabicyclo[7,3,1]trideca-1(13),9,11-triene-12-carbo-nitrile (7a). Imino ethers (4) with fewer than six methylene groups give bicyclic imines which are incapable of rearrangement; those with more than six methylene groups give imines which cannot be isolated on account of their extremely facile rearrangement into β-bridged isomers. Ionization constants and the ultraviolet, infrared, proton magnetic resonance and mass spectra of the main products are discussed.

Published
1975
Full Text
View/download PDF

50. Highly Selective Aldose Reductase Inhibitors. 1. 3-(Arylalkyl)-2,4,5-trioxoimidazolidine-1-acetic Acids

Author

Ishii, A., Kotani, T., Nagaki, Y., Shibayama, Y., Toyomaki, Y., Okukado, N., Ienaga, K., and Okamoto, K.

Abstract

A series of 3-(arylalkyl)-2,4,5-trioxoimidazolidine-1-acetic acids (1) was prepared and tested for aldose reductase (AR) and aldehyde reductase (ALR) inhibitory activities. These compounds showed strong inhibitory activity against AR without significant inhibitory activity for ALR. The ratio of IC50(ALR)/IC50(AR) was >1000 in some compouds. On the basis of pharmacological tests such as the recovery of reduced motor nerve conduction velocity and toxicological profile, 3-(3-nitrobenzyl)-2,4,5-trioxoimidazolidine-1-acetic acid (NZ-314) was selected as the candidate for clinical development.

Published
1996

Catalog

Books, media, physical & digital resources
See catalog results