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5. Radiological and chemical exposures and risks of cancer in the Constances cohort (COREXCA)

Author

LAURENT, Olivier, Renaud, Philippe, Broggio, David, Blanchardon, Eric, Dreuil, Serge, Greau, Claire, Vignaud, Caroline, Ancelet, Sophie, Armant, Olivier, Bernier, Marie-Odile, Clero, Enora, Durand, Christelle, Ebrahimian Chiusa, Teni, Foucault, Anais, Goldberg, Marcel, Guerin, Sabine, Huet, Christelle, Lequy, Emeline, Métivier, Jean-Michel, Grison, Stephane, Ibanez, Chrystelle, Ielsch, Géraldine, Klokov, Dmitry, Monceau, V., Roy, Herve, guihenneuc, chantal, Leuraud, Klervi, Nathalie, Velly, Zins, Marie, Laboratoire d épidémiologie des rayonnements ionisants (IRSN/PSE-SANTE/SESANE/LEPID), Service de recherche sur les effets biologiques et Sanitaires des rayonnements ionisants (IRSN/PSE-SANTE/SESANE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN)-Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Pôle Santé Environnement- Direction Environnement (IRSN/PSE-ENV), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Laboratoire d'évaluation de la dose interne (IRSN/PSE-SANTE/SDOS/LEDI), Service de dosimétrie (IRSN/PSE-SANTE/SDOS), Bureau d'expertise en radioprotection de la population (IRSN/PSE-ENV/SEREN/BERAP), Service d'expertise et d'étude en radioprotection des populations et de la radioactivité dans l'environnement (IRSN/PSE-ENV/SEREN), Unité d'expertise en radioprotection médicale (IRSN/PSE-SANTE/SER/UEM), Service d'études et d'expertise en radioprotection (IRSN/PSE-SANTE/SER), Bureau d'étude et d'expertise du radon (IRSN/PSE-ENV/SEREN/BERAD), Laboratoire d'écotoxicologie des radionucléides (IRSN/PSE-ENV/SRTE/LECO), Service de recherche sur les transferts et les effets des radionucléides sur les écosystèmes (IRSN/PSE-ENV/SRTE), Laboratoire de radiotoxicologie et radiobiologie expérimentale (IRSN/PSE-SANTE/SESANE/LRTOX), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Institut National de l'Environnement Industriel et des Risques (INERIS), Laboratoire de dosimétrie des rayonnements ionisants (IRSN/PSE-SANTE/SDOS/LDRI), Laboratoire d'étude et d'expertise sur la radioactivité de l'environnement (IRSN/PSE-ENV/SEREN/LEREN), Bureau d'analyse et de suivi des expositions professionnelles (IRSN/PSE-SANTE/SER/BASEP), Biostatistique, traitement et modélisation des données biologiques = Biostatistic, Biological Data treatment and Modelisation (BioSTM - URP_7537), Université Paris Cité (UPCité), Fondation de France (grant WB-2020-29711) French Agency for Food, Environmental and Occupational Health & Safety (ANSES, grant EST-21-188), European Radiation Protection Week, and European Project: 900009,RadoNorm

Subjects
[SDV]Life Sciences [q-bio]
Abstract

International audience

Published
2022

6. Radiological component of the Exposome, multiple exposures, risks of cancer and other chronic diseases in the Constances cohort (CORALE)

Author

LAURENT, Olivier, Renaud, Philippe, Dreuil, Serge, Greau, Claire, Vignaud, Caroline, Ancelet, Sophie, Armant, Olivier, Bernier, Marie-Odile, Clero, Enora, Durand, Christelle, Ebrahimian Chiusa, Teni, Goldberg, Marcel, Lequy, Emeline, Grison, Stephane, Ibanez, Chrystelle, Ielsch, Géraldine, Klokov, Dmitry, Monceau, V., Roy, Herve, Guihenneuc, Chantal, Leuraud, Klervi, Zins., Marie, Laboratoire d épidémiologie des rayonnements ionisants (IRSN/PSE-SANTE/SESANE/LEPID), Service de recherche sur les effets biologiques et Sanitaires des rayonnements ionisants (IRSN/PSE-SANTE/SESANE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN)-Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Pôle Santé Environnement- Direction Environnement (IRSN/PSE-ENV), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Unité d'expertise en radioprotection médicale (IRSN/PSE-SANTE/SER/UEM), Service d'études et d'expertise en radioprotection (IRSN/PSE-SANTE/SER), Bureau d'étude et d'expertise du radon (IRSN/PSE-ENV/SEREN/BERAD), Service d'expertise et d'étude en radioprotection des populations et de la radioactivité dans l'environnement (IRSN/PSE-ENV/SEREN), Laboratoire d'écotoxicologie des radionucléides (IRSN/PSE-ENV/SRTE/LECO), Service de recherche sur les transferts et les effets des radionucléides sur les écosystèmes (IRSN/PSE-ENV/SRTE), Laboratoire de radiotoxicologie et radiobiologie expérimentale (IRSN/PSE-SANTE/SESANE/LRTOX), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Bureau d'analyse et de suivi des expositions professionnelles (IRSN/PSE-SANTE/SER/BASEP), Biostatistique, traitement et modélisation des données biologiques = Biostatistic, Biological Data treatment and Modelisation (BioSTM - URP_7537), Université Paris Cité (UPCité), Fondation de France, Radonorm, and European Project: 900009,RadoNorm

Subjects
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract

International audience; ContextThe whole population is exposed throughout its life to ionizing radiation (IR) at varying levels, via multiple natural and artificial sources, whether in the context of the residential environment, various activities (professional or other such as air travel) or for medical reasons (diagnostic or therapeutic procedures). The carcinogenic effects of IR are well documented at dose levels of 100 milliGrays (mGy) or higher. There is still controversy about the shape of the relationships between exposure and cancer risks at lower doses, called “low doses”. In addition, quantification of the effects of multi-exposure to IR and other cancer risk factors is poorly documented, with the exception of the interaction between tobacco and radon on lung cancer risk. Similarly, the relationships between exposures to IR at different stages of life (e.g., during childhood, puberty, etc.) and late health effects remain poorly characterized. Potential associations between low doses of IR and non-cancer chronic diseases also require better documentation. ObjectivesThe first objective of the CORALE project is to carry out the broadest possible reconstruction of doses of IR from environmental sources (radon, terrestrial and cosmic radiation, food, nuclear installations and other artificial sources), medical (diagnostic and therapeutic procedures) and occupational (nuclear workers but also other industries using radioactive sources, health professionals… ) received by participants in the Constances cohort since birth, following the logic of the exposome concept (for its radiological component). The second objective will be to estimate the risks of cancers and other chronic diseases potentially associated with the cumulative doses received (from several sources of IR and over time) taking into account the potential influence of the context of multi-exposures to other risk factors.MethodsIn order to reconstruct the annual doses due to radioactivity of natural and artificial origin received by each member of the Constances cohort since their birth, a large number of sources of radioactivity must be considered. Reconstructions related to environmental, medical and occupational exposures will be performed by different units of the IRSN in collaboration with the Constances cohort team. To do this, a questionnaire will be sent to cohort members who have already provided their residential histories. The statistical analyses (e.g., Cox models with time-dependent covariates) will be carried out at the IRSN epidemiology laboratory and will benefit from the expertise of radiobiologists, supporting the exploration of specific hypotheses and interpretations. The use of innovative regression methods on exposure profiles will be explored in collaboration with the University of Paris.PerspectivesCORALE is part of a broader long-term research programme, which will include the effects of other multi-exposures (e.g., IR and other environmental exposures) and the study of risk and exposure biomarkers through the Constances biobank, further complementing the application of the exposome concept through the study of within-body regulations following exposures. This program will help improve the characterization of the exposome and its relation with chronic diseases in the Constances cohort.

Published
2021

8. Report on the results from the on-site comparison of indoor radon measurements and geogenic radon measurements under field conditions

Author

Cinelli, Giorgia, S. Baumann, Bossew, Peter, S. Celaya, A. Fernandez, E. Fernandez, Fuente, Ismael, Gréau, Claire, Gruber, Valeria, Ielsch, Géraldine, F. J. Maringer, E. Petermann, Sanchez, Ricardo Pol, L. Quindos, J. Quindos, Rábago, Daniel, Sainz, Carlos, Stietka, Michael, Wiedner, Hannah, and Benoit Sabot

Published
2020
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9. Residential Exposure to Natural Background Radiation and Risk of Childhood Acute Leukemia in France, 1990–2009

Author

Demoury, Claire, primary, Marquant, Fabienne, additional, Ielsch, Géraldine, additional, Goujon, Stéphanie, additional, Debayle, Christophe, additional, Faure, Laure, additional, Coste, Astrid, additional, Laurent, Olivier, additional, Guillevic, Jérôme, additional, Laurier, Dominique, additional, Hémon, Denis, additional, and Clavel, Jacqueline, additional

Published
2017
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11. Exposure to natural background radiation and association with childhood leukemia incidence in France 1990-2007

Author

Laurier Dominique, Guillevic Jérôme, Clavel Jacqueline, Ielsch Géraldine, Demoury Claire, Hemon Denis, and Ancelet Sophie

Subjects
Oncology, medicine.medical_specialty, Acute leukemia, Childhood leukemia, business.industry, Incidence (epidemiology), Cancer, macromolecular substances, medicine.disease, Ionizing radiation, Internal medicine, medicine, General Earth and Planetary Sciences, Observational study, business, General Environmental Science, Background radiation
Abstract

Background Several observational studies have reported associations between childhood acute leukemia and exposure to natural background radiation (NBR), but literature on low-dose ionizing radiatio...

Published
2013

12. Bayesian prediction of childhood leukemia risks potentially due to radon, terrestrial gamma and cosmic rays in France

Author

Richardson David, Laurier Dominique, Clavel Jacqueline, Hemon Denis, Laurent Olivier, Ielsch Géraldine, Ancelet Sophie, and Demoury Claire

Subjects
Childhood leukemia, business.industry, Cancer, chemistry.chemical_element, Radon, Cosmic ray, medicine.disease, Ionizing radiation, chemistry, Environmental health, medicine, General Earth and Planetary Sciences, Risk assessment, business, Health impact assessment, General Environmental Science, Background radiation
Abstract

Background: Previous Quantitative Risk Assessments (QRA) have suggested that natural background radiation (NBR) may be a cause of childhood leukemia but have often neglected important sources of un...

Published
2013

16. P-286

Author

Laurent, Olivier, primary, Ancelet, Sophie, additional, Richardson, David, additional, Clavel, Jacqueline, additional, Ielsch, Géraldine, additional, Hémon, Denis, additional, Demoury, Claire, additional, and Laurier, Dominique, additional

Published
2012
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