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35 results on '"Idda, M."'

3. Nuclear morphology is a deep learning biomarker of senescence across tissues and species

Author

Heckenbach, Indra, primary, Mkrtchyan, Garik, additional, Ezra, Michael Ben, additional, Bakula, Daniela, additional, Madsen, Jakob, additional, Nielsen, Malte, additional, Oró, Denise, additional, Idda, M Laura, additional, Gorospe, Myriam, additional, Mortensen, Laust, additional, Verdin, Eric, additional, Westendorp, Rudi, additional, and Scheibye-Knudsen, Morten, additional

Published
2021
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4. Circadian clocks

Author

Idda, M. Laura, primary, Bertolucci, Cristiano, additional, Vallone, Daniela, additional, Gothilf, Yoav, additional, Sánchez-Vázquez, Francisco Javier, additional, and Foulkes, Nicholas S., additional

Published
2012
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7. Cooperative translational control of polymorphic BAFF by NF90 and miR-15a

Author

Idda, M Laura, primary, Lodde, Valeria, additional, McClusky, Waverly G, additional, Martindale, Jennifer L, additional, Yang, Xiaoling, additional, Munk, Rachel, additional, Steri, Maristella, additional, Orrù, Valeria, additional, Mulas, Antonella, additional, Cucca, Francesco, additional, Abdelmohsen, Kotb, additional, and Gorospe, Myriam, additional

Published
2018
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8. GRSF1 suppresses cell senescence

Author

Noh, Ji Heon, primary, Kim, Kyoung Mi, additional, Idda, M. Laura, additional, Martindale, Jennifer L., additional, Yang, Xiaoling, additional, Abdelmohsen, Kotb, additional, and Gorospe, Myriam, additional

Published
2018
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12. Overexpression of the Cytokine BAFF and Autoimmunity Risk

Author

Steri, Maristella, primary, Orrù, Valeria, additional, Idda, M. Laura, additional, Pitzalis, Maristella, additional, Pala, Mauro, additional, Zara, Ilenia, additional, Sidore, Carlo, additional, Faà, Valeria, additional, Floris, Matteo, additional, Deiana, Manila, additional, Asunis, Isadora, additional, Porcu, Eleonora, additional, Mulas, Antonella, additional, Piras, Maria G., additional, Lobina, Monia, additional, Lai, Sandra, additional, Marongiu, Mara, additional, Serra, Valentina, additional, Marongiu, Michele, additional, Sole, Gabriella, additional, Busonero, Fabio, additional, Maschio, Andrea, additional, Cusano, Roberto, additional, Cuccuru, Gianmauro, additional, Deidda, Francesca, additional, Poddie, Fausto, additional, Farina, Gabriele, additional, Dei, Mariano, additional, Virdis, Francesca, additional, Olla, Stefania, additional, Satta, Maria A., additional, Pani, Mario, additional, Delitala, Alessandro, additional, Cocco, Eleonora, additional, Frau, Jessica, additional, Coghe, Giancarlo, additional, Lorefice, Lorena, additional, Fenu, Giuseppe, additional, Ferrigno, Paola, additional, Ban, Maria, additional, Barizzone, Nadia, additional, Leone, Maurizio, additional, Guerini, Franca R., additional, Piga, Matteo, additional, Firinu, Davide, additional, Kockum, Ingrid, additional, Lima Bomfim, Izaura, additional, Olsson, Tomas, additional, Alfredsson, Lars, additional, Suarez, Ana, additional, Carreira, Patricia E., additional, Castillo-Palma, Maria J., additional, Marcus, Joseph H., additional, Congia, Mauro, additional, Angius, Andrea, additional, Melis, Maurizio, additional, Gonzalez, Antonio, additional, Alarcón Riquelme, Marta E., additional, da Silva, Berta M., additional, Marchini, Maurizio, additional, Danieli, Maria G., additional, Del Giacco, Stefano, additional, Mathieu, Alessandro, additional, Pani, Antonello, additional, Montgomery, Stephen B., additional, Rosati, Giulio, additional, Hillert, Jan, additional, Sawcer, Stephen, additional, D’Alfonso, Sandra, additional, Todd, John A., additional, Novembre, John, additional, Abecasis, Gonçalo R., additional, Whalen, Michael B., additional, Marrosu, Maria G., additional, Meloni, Alessandra, additional, Sanna, Serena, additional, Gorospe, Myriam, additional, Schlessinger, David, additional, Fiorillo, Edoardo, additional, Zoledziewska, Magdalena, additional, and Cucca, Francesco, additional

Published
2017
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13. ERK Signaling Regulates Light-Induced Gene Expression via D-Box Enhancers in a Differential, Wavelength-Dependent Manner

Author

Mracek, Philipp, Pagano, Chrstina, Fröhlich, Nadine, Idda, M. Laura, Cuesta, Ines H., Lopez-Olmeda, Jose Fernando, Sánchez-Vázquez, F. Javier, Daniela Vallone, Daniela, and Foulkes, Nicholas S.

Subjects
Life sciences, biology, ddc:570, lcsh:R, lcsh:Medicine, lcsh:Q, sense organs, lcsh:Science
Abstract

The day-night and seasonal cycles are dominated by regular changes in the intensity as well as spectral composition of sunlight. In aquatic environments the spectrum of sunlight is also strongly affected by the depth and quality of water. During evolution, organisms have adopted various key strategies in order to adapt to these changes, including the development of clocks and photoreceptor mechanisms. These mechanisms enable the detection and anticipation of regular changes in lighting conditions and thereby direct an appropriate physiological response. In teleosts, a growing body of evidence points to most cell types possessing complex photoreceptive systems. However, our understanding of precisely how these systems are regulated and in turn dictate changes in gene expression remains incomplete. In this manuscript we attempt to unravel this complexity by comparing the effects of two specific wavelengths of light upon signal transduction and gene expression regulatory mechanisms in zebrafish cells. We reveal a significant difference in the kinetics of light-induced gene expression upon blue and red light exposure. Importantly, both red and blue light-induced gene expression relies upon D-box enhancer promoter elements. Using pharmacological and genetic approaches we demonstrate that the ERK/MAPK pathway acts as a negative regulator of blue but not red light activated transcription. Thus, we reveal that D-box-driven gene expression is regulated via ERK/MAPK signaling in a strongly wavelength-dependent manner.

Published
2013

15. Circadian clocks: Lessons from fish

Author

Idda, M. L., Bertolucci, Cristiano, Vallone, D., Gothilf, Y., Sánchez Vázquez, F. J., and Foulkes, N. S.

Subjects
NO
Published
2012

34. Genetic variants in mRNA untranslated regions.

Author

Steri M, Idda ML, Whalen MB, and Orrù V

Subjects
Animals, Humans, Untranslated Regions genetics, Genetic Variation genetics, RNA, Messenger genetics
Abstract

Genome Wide Association Studies (GWAS) have mapped thousands of genetic variants associated with complex disease risk and regulating quantitative traits, thus exploiting an unprecedented high-resolution genetic characterization of the human genome. A small fraction (3.7%) of the identified associations is located in untranslated regions (UTRs), and the molecular mechanism has been elucidated for few of them. Genetic variations at UTRs may modify regulatory elements affecting the interaction of the UTRs with proteins and microRNAs. The overall functional consequences include modulation of messenger RNA (mRNA) transcription, secondary structure, stability, localization, translation, and access to regulators like microRNAs (miRNAs) and RNA-binding proteins (RBPs). Alterations of these regulatory mechanisms are known to modify molecular pathways and cellular processes, potentially leading to disease processes. Here, we analyze some examples of genetic risk variants mapping in the UTR regulatory elements. We describe a recently identified genetic variant localized in the 3'UTR of the TNFSF13B gene, associated with autoimmunity risk and responsible of an increased stability and translation of TNFSF13B mRNA. We discuss how the correct use and interpretation of public GWAS repositories could lead to a better understanding of etiopathogenetic mechanisms and the generation of robust biological hypothesis as starting point for further functional studies. This article is categorized under: RNA Structure and Dynamics > RNA Structure, Dynamics and Chemistry RNA Evolution and Genomics > Computational Analyses of RNA RNA in Disease and Development > RNA in Disease., (© 2018 Wiley Periodicals, Inc.)

Published
2018
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35. Noncoding RNAs in Alzheimer's disease.

Author

Idda ML, Munk R, Abdelmohsen K, and Gorospe M

Subjects
Animals, Humans, Alzheimer Disease genetics, RNA, Untranslated
Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the main cause of dementia among the elderly worldwide. Despite intense efforts to develop drugs for preventing and treating AD, no effective therapies are available as yet, posing a growing burden at the personal, medical, and socioeconomic levels. AD is characterized by the production and aggregation of amyloid β (Aβ) peptides derived from amyloid precursor protein (APP), the presence of hyperphosphorylated microtubule-associated protein Tau (MAPT), and chronic inflammation leading to neuronal loss. Aβ accumulation and hyperphosphorylated Tau are responsible for the main histopathological features of AD, Aβ plaques, and neurofibrillary tangles (NFTs), respectively. However, the full spectrum of molecular factors that contribute to AD pathogenesis is not known. Noncoding (nc)RNAs, including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), regulate gene expression at the transcriptional and posttranscriptional levels in various diseases, serving as biomarkers and potential therapeutic targets. There is rising recognition that ncRNAs have been implicated in both the onset and pathogenesis of AD. Here, we review the ncRNAs implicated posttranscriptionally in the main AD pathways and discuss the growing interest in targeting regulatory ncRNAs therapeutically to combat AD pathology. WIREs RNA 2018, 9:e1463. doi: 10.1002/wrna.1463 This article is categorized under: RNA in Disease and Development > RNA in Disease., (Published 2018. This article is a U.S. Government work and is in the public domain in the USA.)

Published
2018
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