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1,194 results on '"Idbaih, Ahmed"'

1. Repeated blood–brain barrier opening with a nine-emitter implantable ultrasound device in combination with carboplatin in recurrent glioblastoma: a phase I/II clinical trial

Author

Carpentier, Alexandre, Stupp, Roger, Sonabend, Adam M., Dufour, Henry, Chinot, Olivier, Mathon, Bertrand, Ducray, François, Guyotat, Jacques, Baize, Nathalie, Menei, Philippe, de Groot, John, Weinberg, Jeffrey S., Liu, Benjamin P., Guemas, Eric, Desseaux, Carole, Schmitt, Charlotte, Bouchoux, Guillaume, Canney, Michael, and Idbaih, Ahmed

Published
2024
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3. Ex vivo drug sensitivity screening predicts response to temozolomide in glioblastoma patients and identifies candidate biomarkers

Author

Ntafoulis, Ioannis, Kleijn, Anne, Ju, Jie, Jimenez-Cowell, Kevin, Fabro, Federica, Klein, Michelle, Chi Yen, Romain Tching, Balvers, Rutger K., Li, Yunlei, Stubbs, Andrew P., Kers, Trisha V., Kros, Johan M., Lawler, Sean E., Beerepoot, Laurens V., Kremer, Andreas, Idbaih, Ahmed, Verreault, Maite, Byrne, Annette T., O’Farrell, Alice C., Connor, Kate, Biswas, Archita, Salvucci, Manuela, Prehn, Jochen H. M., Lambrechts, Diether, Dilcan, Gonca, Lodi, Francesca, Arijs, Ingrid, van den Bent, Martin J., Dirven, Clemens M. F., Leenstra, Sieger, and Lamfers, Martine L. M.

Published
2023
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4. Phase III trial of chemoradiotherapy with temozolomide plus nivolumab or placebo for newly diagnosed glioblastoma with methylated MGMT promoter

Author

Lim, Michael, Weller, Michael, Idbaih, Ahmed, Steinbach, Joachim, Finocchiaro, Gaetano, Raval, Raju R, Ansstas, George, Baehring, Joachim, Taylor, Jennie W, Honnorat, Jerome, Petrecca, Kevin, De Vos, Filip, Wick, Antje, Sumrall, Ashley, Sahebjam, Solmaz, Mellinghoff, Ingo K, Kinoshita, Masashi, Roberts, Mustimbo, Slepetis, Ruta, Warad, Deepti, Leung, David, Lee, Michelle, Reardon, David A, and Omuro, Antonio

Subjects
Rare Diseases, Genetics, Clinical Research, Brain Cancer, Clinical Trials and Supportive Activities, Neurosciences, Brain Disorders, Cancer, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Humans, Temozolomide, Glioblastoma, Nivolumab, Brain Neoplasms, Chemoradiotherapy, Adrenal Cortex Hormones, Antineoplastic Agents, Alkylating, DNA Modification Methylases, Tumor Suppressor Proteins, DNA Repair Enzymes, glioblastoma, MGMT promoter, nivolumab, PD-L1, temozolomide, MGMT promoter, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundNearly all patients with newly diagnosed glioblastoma experience recurrence following standard-of-care radiotherapy (RT) + temozolomide (TMZ). The purpose of the phase III randomized CheckMate 548 study was to evaluate RT + TMZ combined with the immune checkpoint inhibitor nivolumab (NIVO) or placebo (PBO) in patients with newly diagnosed glioblastoma with methylated MGMT promoter (NCT02667587).MethodsPatients (N = 716) were randomized 1:1 to NIVO [(240 mg every 2 weeks × 8, then 480 mg every 4 weeks) + RT (60 Gy over 6 weeks) + TMZ (75 mg/m2 once daily during RT, then 150-200 mg/m2 once daily on days 1-5 of every 28-day cycle × 6)] or PBO + RT + TMZ following the same regimen. The primary endpoints were progression-free survival (PFS) and overall survival (OS) in patients without baseline corticosteroids and in all randomized patients.ResultsAs of December 22, 2020, median (m)PFS (blinded independent central review) was 10.6 months (95% CI, 8.9-11.8) with NIVO + RT + TMZ vs 10.3 months (95% CI, 9.7-12.5) with PBO + RT + TMZ (HR, 1.1; 95% CI, 0.9-1.3) and mOS was 28.9 months (95% CI, 24.4-31.6) vs 32.1 months (95% CI, 29.4-33.8), respectively (HR, 1.1; 95% CI, 0.9-1.3). In patients without baseline corticosteroids, mOS was 31.3 months (95% CI, 28.6-34.8) with NIVO + RT + TMZ vs 33.0 months (95% CI, 31.0-35.1) with PBO + RT + TMZ (HR, 1.1; 95% CI, 0.9-1.4). Grade 3/4 treatment-related adverse event rates were 52.4% vs 33.6%, respectively.ConclusionsNIVO added to RT + TMZ did not improve survival in patients with newly diagnosed glioblastoma with methylated or indeterminate MGMT promoter. No new safety signals were observed.

Published
2022

5. Traduction et republication de : « Événements thromboemboliques artériels liés au cancer »

Author

Benhamou, Ygal, Benmaziane, Asmahane, Bertoletti, Laurent, Bichon, Virginie, Bozec, Coralie, Cohen, Ariel, Couturaud, Francis, Debourdeau, Philippe, Dielenseger, Pascale, Douriez, Éric, Élias, Antoine, Espitia, Olivier, Frère, Corinne, Gaboreau, Yoann, Gendron, Pascale, Girard, Philippe, Hanon, Olivier, Idbaih, Ahmed, Laporte, Silvy, Mahé, Isabelle, Mayeur, Didier, Mismetti, Patrick, Moustafa, Farès, Pernod, Gilles, Roy, Pierre-Marie, Rouge Bugat, Marie-Ève, Sanchez, Olivier, Schmidt, Jeannot, Scotté, Florian, and Sevestre, Maie-Antoinette

Published
2024
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6. Long-term outcome and prognosis of mixed histiocytosis (Erdheim-Chester disease and Langerhans Cell Histiocytosis)

Author

Pegoraro, Francesco, Papo, Matthias, Cohen-Aubart, Fleur, Peyronel, Francesco, Lugli, Gianmarco, Trambusti, Irene, Baulier, Gildas, de Menthon, Mathilde, Le Scornet, Tanguy, Oziol, Eric, Ferreira-Maldent, Nicole, Hermine, Olivier, Faucher, Benoit, Koschel, Dirk, Straetmans, Nicole, Abisror, Noémie, Terrier, Benjamin, Lifermann, François, Razanamahery, Jerome, Allenbach, Yves, Keraen, Jeremy, Bulifon, Sophie, Hervier, Baptiste, Buccoliero, Annamaria, Charlotte, Frederic, Monzani, Quentin, Boussouar, Samia, Shor, Natalia, Tondo, Annalisa, Barete, Stephane, Idbaih, Ahmed, Tazi, Abdellatif, Sieni, Elena, Amoura, Zahir, Emile, Jean-François, Vaglio, Augusto, and Haroche, Julien

Published
2024
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8. Management of patients with rare adult solid cancers: objectives and evaluation of European reference networks (ERN) EURACAN

Author

Blay, Jean-Yves, Casali, Paolo, Ray-Coquard, Isabelle, Seckl, Michael J., Gietema, Jourik, de Herder, Wouter W., Caplin, Martyn, Klümpen, Heinz-Josef, Glehen, Olivier, Wyrwicz, Lucjan, Peeters, Robin, Licitra, Lisa, Girard, Nicolas, Piperno-Neumann, Sophie, Kapiteijn, Ellen, Idbaih, Ahmed, Franceschi, Enrico, Trama, Annalisa, Frezza, Anna-Maria, Hohenberger, Peter, Hindi, Nadia, Martin-Broto, Javier, Schell, Johanna, Rogasik, Muriel, Lejeune, Stephane, Oliver, Kathy, de Lorenzo, Francesco, and Weinman, Ariane

Published
2024
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9. Cell of Origin of Brain and Spinal Cord Tumors

Author

Laurenge, Alice, Huillard, Emmanuelle, Bielle, Franck, Idbaih, Ahmed, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Hanaei, Sara, editor

Published
2023
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10. Comparative analysis of deeply phenotyped GBM cohorts of ‘short-term’ and ‘long-term’ survivors

Author

Biswas, Archita, Salvucci, Manuela, Connor, Kate, Düssmann, Heiko, Carberry, Steven, Fichtner, Michael, King, Ellen, Murphy, Brona, O’Farrell, Alice C., Cryan, Jane, Beausang, Alan, Heffernan, Josephine, Cremona, Mattia, Hennessy, Bryan T., Clerkin, James, Sweeney, Kieron J., MacNally, Steve, Brett, Francesca, O’Halloran, Philip, Bacon, Orna, Furney, Simon, Verreault, Maite, Quissac, Emie, Bielle, Franck, Ahmed, Mohammed H., Idbaih, Ahmed, Leenstra, Sieger, Ntafoulis, Ioannis, Fabro, Federica, Lamfers, Martine, Golebiewska, Anna, Hertel, Frank, Niclou, Simone P., Yen, Romain Tching Chi, Kremer, Andreas, Dilcan, Gonca, Lodi, Francesca, Arijs, Ingrid, Lambrechts, Diether, Purushothama, Manasa Kalya, Kel, Alexander, Byrne, Annette T., and Prehn, Jochen H.M.

Published
2023
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11. Deep-learning-based reconstruction of undersampled MRI to reduce scan times: a multicentre, retrospective, cohort study

Author

Rastogi, Aditya, Brugnara, Gianluca, Foltyn-Dumitru, Martha, Mahmutoglu, Mustafa Ahmed, Preetha, Chandrakanth J, Kobler, Erich, Pflüger, Irada, Schell, Marianne, Deike-Hofmann, Katerina, Kessler, Tobias, van den Bent, Martin J, Idbaih, Ahmed, Platten, Michael, Brandes, Alba A, Nabors, Burt, Stupp, Roger, Bernhardt, Denise, Debus, Jürgen, Abdollahi, Amir, Gorlia, Thierry, Tonn, Jörg-Christian, Weller, Michael, Maier-Hein, Klaus H, Radbruch, Alexander, Wick, Wolfgang, Bendszus, Martin, Meredig, Hagen, Kurz, Felix T, and Vollmuth, Philipp

Published
2024
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12. Health-related quality-of-life results from the randomised phase II TAVAREC trial on temozolomide with or without bevacizumab in 1p/19q intact first-recurrence World Health Organization grade 2 and 3 glioma (European Organization for Research and Treatment of Cancer 26091)

Author

Reijneveld, Jaap C., Machingura, Abigirl, Coens, Corneel, Taphoorn, Martin J.B., Taal, Walter, Clement, Paul M., Idbaih, Ahmed, de Vos, Filip Y.F., Klein, Martin, Wick, Wolfgang, Mulholland, Paul J., Lewis, Joanne, Golfinopoulos, Vassilis, Ghislain, Irina, Bottomley, Andrew, and van den Bent, Martin J.

Published
2023
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18. Neuro-Psychological Outcome of ICU-Admitted COVID-19 Patients Presenting With CNS Complications

Author

Pelle, Juliette, Nedelec, Thomas, Marois, Clémence, Delorme, Cecile, Corvol, Jean-Christophe, Delattre, Jean-Yves, Carvalho, Stephanie, Sagnes, Sandrine, Dubois, Bruno, Navarro, Vincent, Louapre, Celine, Stojkovic, Tanya, Idbaih, Ahmed, Rosso, Charlotte, Grabli, David, Gales, Ana Zenovia, Millet, Bruno, Rohaut, Benjamin, Bayen, Eleonore, Dupont, Sophie, Bruneteau, Gaelle, Lehericy, Stephane, Seilhean, Danielle, Durr, Alexandra, Lamari, Foudil, Houot, Marion, Brochard, Vanessa Batista, Lubetzki, Catherine, Seilhean, Danielle, Pradat-Diehl, Pascale, Rosso, Charlotte, Hoang-Xuan, Khe, Fontaine, Bertrand, Naccache, Lionel, Fossati, Philippe, Arnulf, Isabelle, Durr, Alexandra, Carpentier, Alexandre, Edel, Yves, Robain, Gilberte, Thoumie, Philippe, Degos, Bertrand, Sharshar, Tarek, Alamowitch, Sonia, Apartis-Bourdieu, Emmanuelle, Peretti, Charles-Siegried, Ursu, Renata, Dzierzynski, Nathalie, Bourron, Kiyoka Kinugawa, Belmin, Joel, Oquendo, Bruno, Pautas, Eric, Verny, Marc, Samson, Yves, Leder, Sara, Leger, Anne, Deltour, Sandrine, Baronnet, Flore, Bombois, Stephanie, Touat, Mehdi, Idbaih, Ahmed, Sanson, Marc, Dehais, Caroline, Houillier, Caroline, Laigle-Donadey, Florence, Psimaras, Dimitri, Alenton, Agusti, Younan, Nadia, Villain, Nicolas, Grabli, David, del Mar Amador, Maria, Bruneteau, Gaelle, Louapre, Celine, Mariani, Louise-Laure, Mezouar, Nicolas, Mangone, Graziella, Meneret, Aurelie, Hartmann, Andreas, Tarrano, Clement, Bendetowicz, David, Pradat, Pierre-François, Baulac, Michel, Sambin, Sara, Pichit, Phintip, Chochon, Florence, Hesters, Adele, Herlin, Bastien, Nguyen, An Hung, Procher, Valerie, Demoule, Alexandre, Morawiec, Elise, Mayaux, Julien, Faure, Morgan, Ewenczyk, Claire, Coarelli, Giulia, Heinzmann, Anna, Stojkovic, Tanya, Masingue, Marion, Bassez, Guillaume, Navarro, Vincent, An, Isabelle, Worbe, Yulia, Lambrecq, Virginie, Debs, Rabab, Musat, Esteban Munoz, Lenglet, Timothee, Lambrecq, Virginie, Hanin, Aurelie, Chougar, Lydia, Shor, Nathalia, Pyatigorskaya, Nadya, Galanaud, Damien, Leclercq, Delphine, Demeret, Sophie, Rohaut, Benjamin, Cao, Albert, Marois, Clemence, Weiss, Nicolas, Gassama, Salimata, Guennec, Loic Le, Degos, Vincent, Jacquens, Alice, Similowski, Thomas, Morelot-Panzini, Capucine, Rotge, Jean-Yves, Saudreau, Bertrand, Millet, Bruno, Pitron, Victor, Sarni, Nassim, Girault, Nathalie, Maatoug, Redwan, Leu, Smaranda, Bayen, Eleonore, Thivard, Lionel, Mokhtari, Karima, Plu, Isabelle, Gonçalves, Bruno, Bottin, Laure, Yger, Marion, Ouvrard, Gaelle, Haddad, Rebecca, Ketz, Flora, Lafuente, Carmelo, Oasi, Christel, Megabarne, Bruno, Herve, Dominique, Salman, Haysam, Rametti-Lacroux, Armelle, Chalançon, Alize, Herve, Anais, Royer, Hugo, Beauzor, Florence, Maheo, Valentine, Laganot, Christelle, Minelli, Camille, Fekete, Aurelie, Grine, Abel, Biet, Marie, Hilab, Rania, Besnard, Aurore, Bouguerra, Meriem, Goudard, Gwen, Houairi, Saida, Al-Youssef, Saba, Pires, Christine, Oukhedouma, Anissa, Siuda-Krzywicka, Katarzyna, Malkinson, Tal Seidel, Agguini, Hanane, Said, Safia, and Houot, Marion

Published
2023
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20. Challenges in glioblastoma research: focus on the tumor microenvironment

Author

Bikfalvi, Andreas, da Costa, Cristine Alves, Avril, Tony, Barnier, Jean-Vianney, Bauchet, Luc, Brisson, Lucie, Cartron, Pierre Francois, Castel, Hélène, Chevet, Eric, Chneiweiss, Hervé, Clavreul, Anne, Constantin, Bruno, Coronas, Valérie, Daubon, Thomas, Dontenwill, Monique, Ducray, Francois, Entz-Werlé, Natacha, Figarella-Branger, Dominique, Fournier, Isabelle, Frenel, Jean-Sébastien, Gabut, Mathieu, Galli, Thierry, Gavard, Julie, Huberfeld, Gilles, Hugnot, Jean-Philippe, Idbaih, Ahmed, Junier, Marie-Pierre, Mathivet, Thomas, Menei, Philippe, Meyronet, David, Mirjolet, Céline, Morin, Fabrice, Mosser, Jean, Moyal, Elisabeth Cohen-Jonathan, Rousseau, Véronique, Salzet, Michel, Sanson, Marc, Seano, Giorgio, Tabouret, Emeline, Tchoghandjian, Aurélie, Turchi, Laurent, Vallette, Francois M., Vats, Somya, Verreault, Maité, and Virolle, Thierry

Published
2023
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25. Glioblastoma cell motility depends on enhanced oxidative stress coupled with mobilization of a sulfurtransferase

Author

Saurty-Seerunghen, Mirca S., Daubon, Thomas, Bellenger, Léa, Delaunay, Virgile, Castro, Gloria, Guyon, Joris, Rezk, Ahmed, Fabrega, Sylvie, Idbaih, Ahmed, Almairac, Fabien, Burel-Vandenbos, Fanny, Turchi, Laurent, Duplus, Eric, Virolle, Thierry, Peyrin, Jean-Michel, Antoniewski, Christophe, Chneiweiss, Hervé, El-Habr, Elias A., and Junier, Marie-Pierre

Published
2022
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27. Primary Meningeal Melanocytic Tumors of the Central Nervous System: A Review from the Ultra-Rare Brain Tumors Task Force of the European Network for Rare Cancers (EURACAN).

Author

Pellerino, Alessia, Verdijk, Robert M., Nichelli, Lucia, Andratschke, Nicolaus H., Idbaih, Ahmed, and Goldbrunner, Roland

Subjects
MENINGES, DOSE-response relationship (Radiation), CANCER, RADIOTHERAPY, RARE diseases, CANCER patient medical care, CENTRAL nervous system, GENES, GENETIC mutation, BRAIN tumors
Abstract

Simple Summary: The European Network for Rare Cancers (EURACAN) Task Force on Ultra-Rare Brain Tumors (domain 10, subdomain 10) has reviewed the literature extensively regarding primary meningeal melanocytic tumors, which are ultra-rare entities that affect primarily children and young adults and represent an unmet need in neuro-oncology. The review covers the main histological and molecular factors, radiological findings, clinical features, and therapeutic challenges. Further efforts are needed to collect more knowledge on these rare brain tumors to improve the diagnostic tools and provide novel treatment strategies. Background: Primary meningeal melanocytic tumors are ultra-rare entities with distinct histological and molecular features compared with other melanocytic or pigmented lesions, such as brain and leptomeningeal metastases from metastatic melanoma. Methods: The European Network for Rare Cancers (EURACAN) Task Force on Ultra-Rare Brain Tumors (domain 10, subdomain 10) performed a literature review from January 1985 to December 2023 regarding the epidemiologic and clinical characteristics, histological and molecular features, radiological findings, and efficacy of local treatments (surgery and radiotherapy) and systemic treatments for these entities. Results: Molecular analysis can detect specific mutations, including GNAQ, GNA11, SF3B1, EIF1AX, BAP1, that are typically found in circumscribed primary meningeal melanocytic tumors and not in other melanocytic lesions, whereas NRAS and BRAF mutations are typical for diffuse primary meningeal melanocytic tumors. The neuroimaging of the whole neuroaxis suggests a melanocytic nature of a lesion, depicts its circumscribed or diffuse nature, but cannot predict the tumor's aggressiveness. Gross-total resection is the first choice in the case of circumscribed meningeal melanocytoma and melanoma; conversely, meningeal biopsy may be reserved for patients with diffuse and multinodular leptomeningeal spread to achieve a definitive diagnosis. High-dose radiotherapy is rarely indicated in diffuse melanocytic tumors except as palliative treatment to alleviate symptoms. Last, a definitive advantage of a specific systemic treatment could not be concluded, as most of the data available derive from case reports or small cohorts. Conclusions: As primary meningeal melanocytic tumors are extremely rare, the correlations between the clinical characteristics, molecular profile, radiological findings at diagnosis and progression are weak, and poor evidence on the best therapeutic approach is available. There is a need to develop shared platforms and registries to capture more knowledge regarding these ultra-rare entities. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Deep-learning-based synthesis of post-contrast T1-weighted MRI for tumour response assessment in neuro-oncology: a multicentre, retrospective cohort study

Author

Jayachandran Preetha, Chandrakanth, Meredig, Hagen, Brugnara, Gianluca, Mahmutoglu, Mustafa A, Foltyn, Martha, Isensee, Fabian, Kessler, Tobias, Pflüger, Irada, Schell, Marianne, Neuberger, Ulf, Petersen, Jens, Wick, Antje, Heiland, Sabine, Debus, Jürgen, Platten, Michael, Idbaih, Ahmed, Brandes, Alba A, Winkler, Frank, van den Bent, Martin J, Nabors, Burt, Stupp, Roger, Maier-Hein, Klaus H, Gorlia, Thierry, Tonn, Jörg-Christian, Weller, Michael, Wick, Wolfgang, Bendszus, Martin, and Vollmuth, Philipp

Published
2021
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30. Histiocytosis

Author

Emile, Jean-François, Cohen-Aubart, Fleur, Collin, Matthew, Fraitag, Sylvie, Idbaih, Ahmed, Abdel-Wahab, Omar, Rollins, Barrett J, Donadieu, Jean, and Haroche, Julien

Published
2021
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31. SARS-CoV-2 infection in patients with primary central nervous system lymphoma

Author

Laurenge, Alice, Ursu, Renata, Houillier, Caroline, Abdi, Basma, Tebano, Gianpiero, Quemeneur, Cyril, Choquet, Sylvain, Di Blasi, Roberta, Lozano, Fernando, Morales, Andrea, Durán-Peña, Alberto, Sirven-Villaros, Lila, Mathon, Bertrand, Mokhtari, Karima, Bielle, Franck, Martin-Duverneuil, Nadine, Delattre, Jean-Yves, Marcelin, Anne-Geneviève, Pourcher, Valérie, Alentorn, Agusti, Idbaih, Ahmed, Carpentier, Antoine F., Leblond, Véronique, Hoang-Xuan, Khê, and Touat, Mehdi

Published
2021
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33. Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors

Author

Melin, Beatrice S, Barnholtz-Sloan, Jill S, Wrensch, Margaret R, Johansen, Christoffer, Il'yasova, Dora, Kinnersley, Ben, Ostrom, Quinn T, Labreche, Karim, Chen, Yanwen, Armstrong, Georgina, Liu, Yanhong, Eckel-Passow, Jeanette E, Decker, Paul A, Labussière, Marianne, Idbaih, Ahmed, Hoang-Xuan, Khe, Di Stefano, Anna-Luisa, Mokhtari, Karima, Delattre, Jean-Yves, Broderick, Peter, Galan, Pilar, Gousias, Konstantinos, Schramm, Johannes, Schoemaker, Minouk J, Fleming, Sarah J, Herms, Stefan, Heilmann, Stefanie, Nöthen, Markus M, Wichmann, Heinz-Erich, Schreiber, Stefan, Swerdlow, Anthony, Lathrop, Mark, Simon, Matthias, Sanson, Marc, Andersson, Ulrika, Rajaraman, Preetha, Chanock, Stephen, Linet, Martha, Wang, Zhaoming, Yeager, Meredith, Wiencke, John K, Hansen, Helen, McCoy, Lucie, Rice, Terri, Kosel, Matthew L, Sicotte, Hugues, Amos, Christopher I, Bernstein, Jonine L, Davis, Faith, Lachance, Dan, Lau, Ching, Merrell, Ryan T, Shildkraut, Joellen, Ali-Osman, Francis, Sadetzki, Siegal, Scheurer, Michael, Shete, Sanjay, Lai, Rose K, Claus, Elizabeth B, Olson, Sara H, Jenkins, Robert B, Houlston, Richard S, and Bondy, Melissa L

Subjects
Biological Sciences, Genetics, Rare Diseases, Human Genome, Brain Disorders, Cancer, Neurosciences, Prevention, Brain Cancer, Alleles, Brain Neoplasms, Gene Expression Regulation, Neoplastic, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Glioblastoma, Glioma, Humans, Meta-Analysis as Topic, Polymorphism, Single Nucleotide, Quantitative Trait Loci, GliomaScan Consortium, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 × 10-9, odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 × 10-10, OR = 1.24), 16p13.3 (rs2562152; P = 1.93 × 10-8, OR = 1.21), 16q12.1 (rs10852606; P = 1.29 × 10-11, OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 × 10-10, OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 × 10-9, OR = 1.19), 1q44 (rs12076373; P = 2.63 × 10-10, OR = 1.23), 2q33.3 (rs7572263; P = 2.18 × 10-10, OR = 1.20), 3p14.1 (rs11706832; P = 7.66 × 10-9, OR = 1.15), 10q24.33 (rs11598018; P = 3.39 × 10-8, OR = 1.14), 11q21 (rs7107785; P = 3.87 × 10-10, OR = 1.16), 14q12 (rs10131032; P = 5.07 × 10-11, OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 × 10-9, OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.

Published
2017

36. Present and Future of Immunotherapy in Patients With Glioblastoma: Limitations and Opportunities.

Author

Maccari, Marta, Baek, Chooyoung, Caccese, Mario, Mandruzzato, Susanna, Fiorentino, Alba, Internò, Valeria, Bosio, Alberto, Cerretti, Giulia, Padovan, Marta, Idbaih, Ahmed, and Lombardi, Giuseppe

Subjects
IMMUNIZATION, GLIOMAS, RADIOTHERAPY, IMMUNOTHERAPY, CANCER vaccines, IMMUNE checkpoint inhibitors, PROGRAMMED cell death 1 receptors, NIVOLUMAB, IMMUNOSUPPRESSION, REGULATORY T cells
Abstract

Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor. Standard therapies, including surgical resection, chemoradiation, and tumor treating fields, have not resulted in major improvements in the survival outcomes of patients with GBM. The lack of effective strategies has led to an increasing interest in immunotherapic approaches, considering the success in other solid tumors. However, GBM is a highly immunosuppressive tumor, as documented by the presence of several mechanisms of immune escape, which may represent a reason why immunotherapy clinical trials failed in this kind of tumor. In this review, we examine the current landscape of immunotherapy strategies in GBM, focusing on the challenge of immunoresistance and potential mechanisms to overcome it. We discussed completed and ongoing clinical trials involving immune checkpoint inhibitors, oncolytic viruses, vaccines, and CAR T-cell therapies, to provide insights into the efficacy and outcomes of different immunotherapeutic interventions. We also explore the impact of radiotherapy on the immune system within the GBM microenvironment highlighting the complex interactions between radiation treatment and the immune response. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Initial surgical resection and long time to occurrence from initial diagnosis are independent prognostic factors in resected recurrent IDH wild-type glioblastoma

Author

Seyve, Antoine, Lozano-Sanchez, Fernando, Thomas, Alice, Mathon, Bertrand, Tran, Suzanne, Mokhtari, Karima, Giry, Marine, Marie, Yannick, Capelle, Laurent, Peyre, Matthieu, Carpentier, Alexandre, Feuvret, Loic, Sanson, Marc, Hoang-Xuan, Khê, Honnorat, Jérome, Delattre, Jean-Yves, Ducray, François, and Idbaih, Ahmed

Published
2020
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39. Multi-platform molecular profiling of a large cohort of glioblastomas reveals potential therapeutic strategies

Author

Xiu, Joanne, Piccioni, David, Juarez, Tiffany, Pingle, Sandeep C, Hu, Jethro, Rudnick, Jeremy, Fink, Karen, Spetzler, David B, Maney, Todd, Ghazalpour, Anatole, Bender, Ryan, Gatalica, Zoran, Reddy, Sandeep, Sanai, Nader, Idbaih, Ahmed, Glantz, Michael, and Kesari, Santosh

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Genetics, Brain Cancer, Neurosciences, Human Genome, Rare Diseases, Cancer, Brain Disorders, Good Health and Well Being, Adult, Age Factors, Aged, Aged, 80 and over, Biomarkers, Tumor, Brain Neoplasms, DNA Methylation, Gene Amplification, Glioblastoma, Humans, Middle Aged, Mutation, Prognosis, Promoter Regions, Genetic, Survival Analysis, Tumor Suppressor Proteins, Young Adult, glioblastoma, tumor profiling, EGFRvIII, IDH1, MGMT promoter methylation, Oncology and carcinogenesis
Abstract

Glioblastomas (GBM) are the most aggressive and prevalent form of gliomas with abysmal prognosis and limited treatment options. We analyzed clinically relevant molecular aberrations suggestive of response to therapies in 1035 GBM tumors. Our analysis revealed mutations in 39 genes of 48 tested. IHC revealed expression of PD-L1 in 19% and PD-1 in 46%. MGMT-methylation was seen in 43%, EGFRvIII in 19% and 1p19q co-deletion in 2%. TP53 mutation was associated with concurrent mutations, while IDH1 mutation was associated with MGMT-methylation and TP53 mutation and was mutually exclusive of EGFRvIII mutation. Distinct biomarker profiles were seen in GBM compared with WHO grade III astrocytoma, suggesting different biology and potentially different treatment approaches. Analysis of 17 metachronous paired tumors showed frequent biomarker changes, including MGMT-methylation and EGFR aberrations, indicating the need for a re-biopsy for tumor profiling to direct subsequent therapy. MGMT-methylation, PR and TOPO1 appeared as significant prognostic markers in sub-cohorts of GBM defined by age. The current study represents the largest biomarker study on clinical GBM tumors using multiple technologies to detect gene mutation, amplification, protein expression and promoter methylation. These data will inform planning for future personalized biomarker-based clinical trials and identifying effective treatments based on tumor biomarkers.

Published
2016

42. EXTH-59. IDENTIFICATION OF GROWTH HORMONE RECEPTOR AS A RELEVANT TARGET FOR PRECISION MEDICINE IN LOW-EGFR EXPRESSING GLIOBLASTOMA

Author

Verreault, Maite, primary, Vilchis, Irma Segoviano, additional, Rosenberg, Shai, additional, Lemaire, Nolwenn, additional, Schmitt, Charlotte, additional, Guehennec, Jeremy, additional, Royer-Perron, Louis, additional, Thomas, Jean-Leon, additional, Lam, Tukiet T, additional, Dingli, Florent, additional, Loew, Damarys, additional, Ducray, Francois, additional, Paris, Sophie, additional, Carpentier, Catherine, additional, Marie, Yannick, additional, Laigle-Donadey, Florence, additional, Rousseau, Audrey, additional, Pigat, Natascha, additional, Boutillon, Florence, additional, Bielle, Franck, additional, Mokhtari, Karima, additional, Frank, Stuart J, additional, de Reynies, Aurelien, additional, Hoang-Xuan, Khe, additional, Sanson, Marc, additional, Goffin, Vincent, additional, and Idbaih, Ahmed, additional

Published
2023
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43. CTNI-58. UPDATED RESULTS AND MOLECULAR SUBGROUP ANALYSES FROM THE RANDOMIZED PHASE 3 MIRAGE TRIAL ON MARIZOMIB IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA

Author

Roth, Patrick, primary, Gorlia, Thierry, additional, Reijneveld, Jaap, additional, de Vos, Filip, additional, Idbaih, Ahmed, additional, Frenel, Jean-Sébastien, additional, Le Rhun, Emilie, additional, Sepúlveda, Juan, additional, Perry, James, additional, Masucci, G Laura, additional, Freres, Pierre, additional, Hirte, Hal, additional, Seidel, Clemens, additional, Walenkamp, Annemiek, additional, Lukacova, Slavka, additional, Meijnders, Paul, additional, Blais, Andre, additional, Ducray, Francois, additional, Verschaeve, Vincent, additional, Nicholas, Garth, additional, Balana, Carmen, additional, Bota, Daniela, additional, Preusser, Matthias, additional, Nuyens, Sarah, additional, Dhermain, Fréderic, additional, van den Bent, Martin, additional, O’Callaghan, Chris J, additional, Vanlancker, Maureen, additional, Mason, Warren, additional, and Weller, Michael, additional

Published
2023
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46. 638 Characterisation of the immune response to EO2401, a new immunotherapy approach against cancer, plus nivolumab in recurrent glioblastoma: The EOGBM1–18/ROSALIE study

Author

Maia, Ana, primary, Toussaint, Hélène, additional, Magalhaes, Joao Gamelas, additional, Idbaih, Ahmed, additional, Villar, Maria Vieito, additional, Tabatabai, Ghazaleh, additional, Stradella, Agostina, additional, Ghiringhelli, Francois, additional, Burger, Michael C, additional, Mildenberger, Iris, additional, Herrlinger, Ulrich, additional, González, Macarena, additional, Hervieu, Alice, additional, GilMartin, Marta, additional, Renovanz, Mirjam, additional, Touat, Mehdi, additional, Wen, Patrick, additional, Wick, Antje, additional, Bonny, Christophe, additional, Paillarse, Jean-Michel, additional, Reardon, David, additional, Wick, Wolfgang, additional, and Gouttefangeas, Cécile, additional

Published
2023
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47. CTIM-25. EO2401 PEPTIDE IMMUNOTHERAPY + NIVOLUMAB +/- BEVACIZUMAB IN FIRST RECURRENT GLIOBLASTOMA: THE PHASE 1/2 EOGBM1-18/ROSALIE STUDY (NCT04116658)

Author

Reardon, David, primary, Idbaih, Ahmed, additional, Vieito, Maria, additional, Ghiringhelli, François, additional, Stradella, Agostina, additional, Tabatabai, Ghazaleh, additional, Burger, Michael C, additional, Mildenberger, Iris, additional, Herrlinger, Ulrich, additional, Wen, Patrick, additional, Touat, Mehdi, additional, Wick, Antje, additional, González, Macarena, additional, Hervieu, Alice, additional, GilMartin, Marta, additional, Renovanz, Mirjam, additional, Gouttefangeas, Cécile, additional, Maia, Ana, additional, Bonny, Christophe, additional, Paillarse, Jean-Michel, additional, Chêne, Laurent, additional, Fagerberg, Jan, additional, and Wick, Wolfgang, additional

Published
2023
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48. Genomic Exploration of Distinct Molecular Phenotypes Steering Temozolomide Resistance Development in Patient-Derived Glioblastoma Cells

Author

Fabro, Federica, primary, Kers, Trisha V., additional, Feller, Kate J., additional, Beerens, Cecile, additional, Ntafoulis, Ioannis, additional, Idbaih, Ahmed, additional, Verreault, Maite, additional, Connor, Kate, additional, Biswas, Archita, additional, Salvucci, Manuela, additional, Prehn, Jochen H. M., additional, Byrne, Annette T., additional, O'Farrell, Alice C., additional, Lambrechts, Diether, additional, Dilcan, Gonca, additional, Lodi, Francesca, additional, Arijs, Ingrid, additional, Kremer, Andreas, additional, Tching Chi Yen, Romain, additional, Chien, Miao-Ping, additional, Lamfers, Martine L. M., additional, and Leenstra, Sieger, additional

Published
2023
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49. Supplementary Figure S4 from Prognostic Markers of DNA Methylation and Next-Generation Sequencing in Progressive Glioblastoma from the EORTC-26101 Trial

Author

Kessler, Tobias, primary, Schrimpf, Daniel, primary, Doerner, Laura, primary, Hai, Ling, primary, Kaulen, Leon D., primary, Ito, Jakob, primary, van den Bent, Martin, primary, Taphoorn, Martin, primary, Brandes, Alba A., primary, Idbaih, Ahmed, primary, Dômont, Julien, primary, Clement, Paul M., primary, Campone, Mario, primary, Bendszus, Martin, primary, von Deimling, Andreas, primary, Sahm, Felix, primary, Platten, Michael, primary, Wick, Wolfgang, primary, and Wick, Antje, primary

Published
2023
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50. Supplementary Table S2 from Prognostic Markers of DNA Methylation and Next-Generation Sequencing in Progressive Glioblastoma from the EORTC-26101 Trial

Author

Kessler, Tobias, primary, Schrimpf, Daniel, primary, Doerner, Laura, primary, Hai, Ling, primary, Kaulen, Leon D., primary, Ito, Jakob, primary, van den Bent, Martin, primary, Taphoorn, Martin, primary, Brandes, Alba A., primary, Idbaih, Ahmed, primary, Dômont, Julien, primary, Clement, Paul M., primary, Campone, Mario, primary, Bendszus, Martin, primary, von Deimling, Andreas, primary, Sahm, Felix, primary, Platten, Michael, primary, Wick, Wolfgang, primary, and Wick, Antje, primary

Published
2023
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