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775 results on '"Ichinose, Kunihiro"'

1. Effectiveness and safety of rituximab in severely relapsed antineutrophil cytoplasmic antibody–associated vasculitis: a retrospective analysis of a Japanese multicentre cohort from the J-CANVAS

Author

Kidoguchi, Genki, Yoshida, Yusuke, Watanabe, Hirofumi, Sugimoto, Tomohiro, Mokuda, Sho, Kida, Takashi, Yajima, Nobuyuki, Omura, Satoshi, Nakagomi, Daiki, Abe, Yoshiyuki, Kadoya, Masatoshi, Takizawa, Naoho, Nomura, Atsushi, Kukida, Yuji, Kondo, Naoya, Yamano, Yasuhiko, Yanagida, Takuya, Endo, Koji, Matsui, Kiyoshi, Takeuchi, Tohru, Ichinose, Kunihiro, Kato, Masaru, Yanai, Ryo, Matsuo, Yusuke, Shimojima, Yasuhiro, Nishioka, Ryo, Okazaki, Ryota, Takata, Tomoaki, Ito, Takafumi, Moriyama, Mayuko, Takatani, Ayuko, Miyawaki, Yoshia, Ito-Ihara, Toshiko, Kawaguchi, Takashi, Kawahito, Yutaka, and Hirata, Shintaro

Published
2024
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2. Clinical practice pattern of Pneumocystis pneumonia prophylaxis in systemic lupus erythematosus: a cross-sectional study from lupus registry of nationwide institutions (LUNA)

Author

Onishi, Takahisa, Sada, Ken-ei, Hayashi, Keigo, Miyawaki, Yoshia, Yoshimi, Ryusuke, Shimojima, Yasuhiro, Ohno, Shigeru, Kajiyama, Hiroshi, Ichinose, Kunihiro, Sato, Shuzo, Fujiwara, Michio, Yajima, Nobuyuki, Kida, Takashi, Matsuo, Yusuke, Nishimura, Keisuke, and Yamane, Takashi

Published
2024
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3. Evaluating the safety profile of calcineurin inhibitors: cancer risk in patients with systemic lupus erythematosus from the LUNA registry—a historical cohort study

Author

Ichinose, Kunihiro, Sato, Shuntaro, Igawa, Takashi, Okamoto, Momoko, Takatani, Ayuko, Endo, Yushiro, Tsuji, Sosuke, Shimizu, Toshimasa, Sumiyoshi, Remi, Koga, Tomohiro, Kawashiri, Shin-ya, Iwamoto, Naoki, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Yajima, Nobuyuki, Sada, Ken-Ei, Miyawaki, Yoshia, Yoshimi, Ryusuke, Shimojima, Yasuhiro, Ohno, Shigeru, Kajiyama, Hiroshi, Sato, Shuzo, Fujiwara, Michio, and Kawakami, Atsushi

Published
2024
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8. Hypertrophic pachymeningitis in ANCA-associated vasculitis: a cross-sectional and multi-institutional study in Japan (J-CANVAS)

Author

Shimojima, Yasuhiro, Kishida, Dai, Ichikawa, Takanori, Kida, Takashi, Yajima, Nobuyuki, Omura, Satoshi, Nakagomi, Daiki, Abe, Yoshiyuki, Kadoya, Masatoshi, Takizawa, Naoho, Nomura, Atsushi, Kukida, Yuji, Kondo, Naoya, Yamano, Yasuhiko, Yanagida, Takuya, Endo, Koji, Hirata, Shintaro, Matsui, Kiyoshi, Takeuchi, Tohru, Ichinose, Kunihiro, Kato, Masaru, Yanai, Ryo, Matsuo, Yusuke, Nishioka, Ryo, Okazaki, Ryota, Takata, Tomoaki, Ito, Takafumi, Moriyama, Mayuko, Takatani, Ayuko, Miyawaki, Yoshia, Ito-Ihara, Toshiko, Kawaguchi, Takashi, Kawahito, Yutaka, and Sekijima, Yoshiki

Published
2022
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10. Characteristic features of late-onset systemic lupus erythematosus: An observational study of data from the Lupus Registry of Nationwide Institutions.

Author

Sakurai, Natsuki, Yoshimi, Ryusuke, Yajima, Nobuyuki, Hidekawa, Chiharu, Kunishita, Yosuke, Kishimoto, Daiga, Sugiyama, Yumiko Kawahara, Kojitani, Noriko, Suzuki, Naoki, Yoshioka, Yuji, Komiya, Takaaki, Takase-Minegishi, Kaoru, Kirino, Yohei, Sada, Ken-ei, Miyawaki, Yoshia, Ichinose, Kunihiro, Ohno, Shigeru, Kajiyama, Hiroshi, Sato, Shuzo, and Shimojima, Yasuhiro

Subjects
SYSTEMIC lupus erythematosus, EXANTHEMA, MULTIVARIATE analysis, AGE of onset, LOGISTIC regression analysis
Abstract

Objective: Late-onset systemic lupus erythematosus (LoSLE) is known to possess characteristics different from those of early-onset SLE (EoSLE), thereby making their diagnosis difficult. This study aimed to assess the characteristic features of LoSLE in Japan, a model country with a super-aged society. Methods: Data were obtained from the Lupus Registry of Nationwide Institutions, which includes a multicenter cohort of patients with SLE in Japan who satisfied the 1997 American College of Rheumatology revised classification criteria for SLE. Data were compared between patients with LoSLE (≥50 years old at onset) and EoSLE (<50 years old at onset). To identify factors associated with LoSLE, binary logistic regression was used for the multivariate analysis, and missing values were complemented by multiple imputations. We also conducted a sub-analysis for patients diagnosed within 5 years of onset. Results: Out of 929 enrolled patients, 34 were excluded owing to a lack of data regarding onset age. Among the 895 remaining patients, 100 had LoSLE, whereas 795 had EoSLE. The male-to-female ratio was significantly higher in the LoSLE group than in the EoSLE group (0.32 vs 0.11, p < 0.001). With respect to SLEDAI components at onset, patients with LoSLE exhibited a higher frequency of myositis (11.9% vs 3.75%, p = 0.031), lower frequency of skin rash (33.3% vs 67.7%, p < 0.001), and lower frequency of alopecia (7.32% vs 24.7%, p = 0.012). No significant differences in overall disease activity at onset were observed between the two groups. Regarding medical history, immunosuppressants were more commonly used in EoSLE. A multivariate analysis revealed that a higher male proportion and a lower proportion of new rash at onset were independent characteristic features of LoSLE. We also identified late onset as an independent risk factor for a high SDI score at enrollment and replicated the result in a sub-analysis for the population with a shorter time since onset. Conclusions: We clarified that LoSLE was characterized by a higher male proportion, a lower frequency of skin rash and a tendency to organ damage. Now that the world is faced with aging, our results may be helpful at diagnosis of LoSLE. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Effectiveness of intravenous methylprednisolone pulse in patients with severe microscopic polyangiitis and granulomatosis with polyangiitis.

Author

Omura, Satoshi, Kida, Takashi, Noma, Hisashi, Inoue, Hironori, Sofue, Hideaki, Sakashita, Aki, Kadoya, Masatoshi, Nakagomi, Daiki, Abe, Yoshiyuki, Takizawa, Naoho, Nomura, Atsushi, Kukida, Yuji, Kondo, Naoya, Yamano, Yasuhiko, Yanagida, Takuya, Endo, Koji, Hirata, Shintaro, Matsui, Kiyoshi, Takeuchi, Tohru, and Ichinose, Kunihiro

Subjects
MORTALITY, STATISTICAL models, RESEARCH funding, CREATININE, MICROSCOPIC polyangiitis, STATISTICAL sampling, MULTIPLE regression analysis, SEVERITY of illness index, RANDOMIZED controlled trials, ACUTE kidney failure, INFECTION, DESCRIPTIVE statistics, INTRAVENOUS therapy, GRANULOMATOSIS with polyangiitis, GLOMERULONEPHRITIS, LONGITUDINAL method, DRUG efficacy, RESEARCH methodology, MEDICAL records, ACQUISITION of data, METHYLPREDNISOLONE, DISEASE relapse, CONFIDENCE intervals, DATA analysis software, HEMORRHAGE, PROPORTIONAL hazards models, GLOMERULAR filtration rate
Abstract

Objectives To evaluate the effectiveness and safety of two different intravenous methylprednisolone (IVMP) pulse doses in patients with severe microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA). Methods We emulated a target trial using observational data from the nationwide registry in Japan. Patients with severe glomerulonephritis or diffuse alveolar haemorrhage were selected and pseudo-randomized into three groups using propensity score-based overlap weighting as follows: non-IVMP, IVMP 0.5 g/day and IVMP 1.0 g/day. The primary outcome was all-cause mortality, and the secondary outcomes were composite all-cause mortality and kidney failure, severe relapse and serious infection from 2 to 48 weeks after treatment initiation. To estimate the treatment effects, the Cox proportional hazard model and Fine–Gray subdistribution hazard model were used. Results In this emulated target trial, of 201 eligible patients (MPA, 175; GPA, 26), 6 (3%) died, 4 (2.0%) had kidney failure, 11 (5.5%) had severe relapse, and 40 (19.9%) had severe infections. Hazard ratios (HR) for IVMP 0.5 g/day and IVMP 1.0 g/day pulse groups compared with non-IVMP pulse were as follows: all-cause mortality 0.46 (95% CI: 0.07, 2.81) and 0.07 (95% CI: 0.01, 0.41), respectively; all-cause mortality/kidney failure 1.18 (95% CI: 0.26, 5.31) and 0.59 (95% CI: 0.08, 4.52), respectively; subdistribution HRs for severe relapse were 1.26 (95% CI: 0.12, 13.70) and 3.36 (95% CI: 0.49, 23.29), respectively; and for serious infection 1.88 (95% CI: 0.76, 4.65) and 0.94 (95% CI: 0.28, 3.13), respectively. Conclusion IVMP 1.0 g/day pulse may improve 48-week mortality in patients with severe MPA/GPA. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Headache in systemic lupus erythematosus: The LUNA registry cross-sectional study

Author

Takamatsu, Ryota, primary, Shimojima, Yasuhiro, additional, Kishida, Dai, additional, Ichikawa, Takanori, additional, Ueno, Ken-ichi, additional, Miyawaki, Yoshia, additional, Yajima, Nobuyuki, additional, Sada, Ken-Ei, additional, Ichinose, Kunihiro, additional, Yoshimi, Ryusuke, additional, Ohno, Shigeru, additional, Kajiyama, Hiroshi, additional, Fujiwara, Michio, additional, Sato, Shuzo, additional, Kida, Takashi, additional, Matsuo, Yusuke, additional, Nishimura, Keisuke, additional, Toriyama, Toshihide, additional, and Sekijima, Yoshiki, additional

Published
2024
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15. Association of glucocorticoid doses and emotional health in lupus low disease activity state (LLDAS): a cross-sectional study

Author

Miyawaki, Yoshia, Shimizu, Sayaka, Ogawa, Yusuke, Sada, Ken-ei, Katayama, Yu, Asano, Yosuke, Hayashi, Keigo, Yamamura, Yuriko, Hiramatsu-Asano, Sumie, Ohashi, Keiji, Morishita, Michiko, Watanabe, Haruki, Takano-Narazaki, Mariko, Matsumoto, Yoshinori, Yajima, Nobuyuki, Yoshimi, Ryusuke, Shimojima, Yasuhiro, Ohno, Shigeru, Kajiyama, Hiroshi, Ichinose, Kunihiro, Sato, Shuzo, Fujiwara, Michio, Yamazaki, Hajime, Yamamoto, Yosuke, Wada, Jun, and Fukuhara, Shunichi

Published
2021
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16. Granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-α in combination is a useful diagnostic biomarker to distinguish familial Mediterranean fever from sepsis

Author

Koga, Tomohiro, Furukawa, Kaori, Migita, Kiyoshi, Morimoto, Shimpei, Shimizu, Toshimasa, Fukui, Shoichi, Umeda, Masataka, Endo, Yushiro, Sumiyoshi, Remi, Kawashiri, Shin-ya, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Origuchi, Tomoki, Maeda, Takahiro, Yachie, Akihiro, and Kawakami, Atsushi

Published
2021
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17. Comparative study of the effect of neuromuscular electrical stimulation and oral administration of branched-chain amino acid on preventing sarcopenia in patients after living-donor liver transplantation: study protocol for an open-label randomized controlled trial

Author

Haraguchi, Masafumi, Ichinose, Kunihiro, Miyaaki, Hisamitsu, Hanada, Masatoshi, Fukushima, Masanori, Sasaki, Ryu, Miuma, Satoshi, Hara, Takanobu, Kugiyama, Tota, Soyama, Akihiko, Hidaka, Masaaki, Tsuji, Ayumi, Yano, Rintaro, Sekino, Motohiro, Takahata, Hideaki, Eguchi, Susumu, and Nakao, Kazuhiko

Published
2021
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18. Association between serum bone biomarker levels and therapeutic response to abatacept in patients with rheumatoid arthritis (RA): a multicenter, prospective, and observational RA ultrasound cohort study in Japan

Author

Kawashiri, Shin-ya, Endo, Yushiro, Nishino, Ayako, Okamoto, Momoko, Tsuji, Sosuke, Takatani, Ayuko, Shimizu, Toshimasa, Sumiyoshi, Remi, Koga, Tomohiro, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Aramaki, Toshiyuki, Ueki, Yukitaka, Yoshitama, Tamami, Eiraku, Nobutaka, Matsuoka, Naoki, Okada, Akitomo, Fujikawa, Keita, Hamada, Hiroaki, Nagano, Shuji, Tada, Yoshifumi, and Kawakami, Atsushi

Published
2021
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19. Real-world comparative effectiveness and safety of tofacitinib and baricitinib in patients with rheumatoid arthritis

Author

Iwamoto, Naoki, Sato, Shuntaro, Kurushima, Shota, Michitsuji, Toru, Nishihata, Shinya, Okamoto, Momoko, Tsuji, Yoshika, Endo, Yushiro, Shimizu, Toshimasa, Sumiyoshi, Remi, Suzuki, Takahisa, Okada, Akitomo, Koga, Tomohiro, Kawashiri, Shin-ya, Fujikawa, Keita, Igawa, Takashi, Aramaki, Toshiyuki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Mizokami, Akinari, Origuchi, Tomoki, Ueki, Yukitaka, Eguchi, Katsumi, and Kawakami, Atsushi

Published
2021
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21. Podocyte foot process width is a prediction marker for complete renal response at 6 and 12 months after induction therapy in lupus nephritis

Author

Ichinose, Kunihiro, Kitamura, Mineaki, Sato, Shuntaro, Fujikawa, Keita, Horai, Yoshiro, Matsuoka, Naoki, Tsuboi, Masahiko, Nonaka, Fumiaki, Shimizu, Toshimasa, Fukui, Shoichi, Umeda, Masataka, Koga, Tomohiro, Kawashiri, Shin-ya, Iwamoto, Naoki, Igawa, Takashi, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Nishino, Tomoya, and Kawakami, Atsushi

Published
2018
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22. Optimal dose of intravenous cyclophosphamide during remission induction therapy in ANCA-associated vasculitis: A retrospective cohort study of J-CANVAS

Author

Sofue, Hideaki, primary, Kida, Takashi, additional, Hirano, Aiko, additional, Omura, Satoshi, additional, Kadoya, Masatoshi, additional, Nakagomi, Daiki, additional, Abe, Yoshiyuki, additional, Takizawa, Naoho, additional, Nomura, Atsushi, additional, Kukida, Yuji, additional, Kondo, Naoya, additional, Yamano, Yasuhiko, additional, Yanagida, Takuya, additional, Endo, Koji, additional, Hirata, Shintaro, additional, Matsui, Kiyoshi, additional, Takeuchi, Tohru, additional, Ichinose, Kunihiro, additional, Kato, Masaru, additional, Yanai, Ryo, additional, Matsuo, Yusuke, additional, Shimojima, Yasuhiro, additional, Nishioka, Ryo, additional, Okazaki, Ryota, additional, Takata, Tomoaki, additional, Ito, Takafumi, additional, Moriyama, Mayuko, additional, Takatani, Ayuko, additional, Miyawaki, Yoshia, additional, Ito-Ihara, Toshiko, additional, Yajima, Nobuyuki, additional, Kawaguchi, Takashi, additional, Fujioka, Kazuki, additional, Fujii, Wataru, additional, Seno, Takahiro, additional, Wada, Makoto, additional, Kohno, Masataka, additional, and Kawahito, Yutaka, additional

Published
2023
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23. Protective effect of hydroxychloroquine on infections in patients with systemic lupus erythematosus: an observational study using the LUNA registry

Author

Hidekawa, Chiharu, primary, Yoshimi, Ryusuke, additional, Saigusa, Yusuke, additional, Tamura, Jun, additional, Kojitani, Noriko, additional, Suzuki, Naoki, additional, Sakurai, Natsuki, additional, Yoshioka, Yuji, additional, Sugiyama-Kawahara, Yumiko, additional, Kunishita, Yosuke, additional, Kishimoto, Daiga, additional, Higashitani, Kana, additional, Sato, Yuichiro, additional, Komiya, Takaaki, additional, Nagai, Hideto, additional, Hamada, Naoki, additional, Maeda, Ayaka, additional, Tsuchida, Naomi, additional, Hirahara, Lisa, additional, Soejima, Yutaro, additional, Takase-Minegishi, Kaoru, additional, Kirino, Yohei, additional, Yajima, Nobuyuki, additional, Sada, Ken-ei, additional, Miyawaki, Yoshia, additional, Ichinose, Kunihiro, additional, Ohno, Shigeru, additional, Kajiyama, Hiroshi, additional, Sato, Shuzo, additional, Shimojima, Yasuhiro, additional, Fujiwara, Michio, additional, and Nakajima, Hideaki, additional

Published
2023
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24. Novel anti-suprabasin antibodies may contribute to the pathogenesis of neuropsychiatric systemic lupus erythematosus

Author

Ichinose, Kunihiro, Ohyama, Kaname, Furukawa, Kaori, Higuchi, Osamu, Mukaino, Akihiro, Satoh, Katsuya, Nakane, Shunya, Shimizu, Toshimasa, Umeda, Masataka, Fukui, Shoichi, Nishino, Ayako, Nakajima, Hideki, Koga, Tomohiro, Kawashiri, Shin-ya, Iwamoto, Naoki, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Yoshida, Mari, Kuroda, Naotaka, and Kawakami, Atsushi

Published
2018
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25. CD4+ CD52lo T-cell expression contributes to the development of systemic lupus erythematosus

Author

Umeda, Masataka, Koga, Tomohiro, Ichinose, Kunihiro, Igawa, Takashi, Sato, Tomohito, Takatani, Ayuko, Shimizu, Toshimasa, Fukui, Shoichi, Nishino, Ayako, Horai, Yoshiro, Hirai, Yasuko, Kawashiri, Shin-ya, Iwamoto, Naoki, Aramaki, Toshiyuki, Tamai, Mami, Nakamura, Hideki, Yamamoto, Kazuo, Abiru, Norio, Origuchi, Tomoki, Ueki, Yukitaka, and Kawakami, Atsushi

Published
2018
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26. Denosumab is effective toward glucocorticoid-induced osteoporosis patients complicated with rheumatic diseases regardless of prior anti-osteoporotic drugs

Author

Iwamoto, Naoki, Okamoto, Momoko, Tsuji, Sosuke, Endo, Yushiro, Takatani, Ayuko, Shimizu, Toshimasa, Umeda, Masataka, Fukui, Shoichi, Sumiyoshi, Remi, Igawa, Takashi, Koga, Tomohiro, Kawashiri, Shin-ya, Aramaki, Toshiyuki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Eguchi, Katsumi, Ueki, Yukitaka, and Kawakami, Atsushi

Published
2019
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28. Utility of a simplified ultrasonography scoring system among patients with rheumatoid arthritis: A multicenter cohort study

Author

Endo, Yushiro, Kawashiri, Shin-ya, Morimoto, Shimpei, Nishino, Ayako, Okamoto, Momoko, Tsuji, Sosuke, Takatani, Ayuko, Shimizu, Toshimasa, Sumiyoshi, Remi, Igawa, Takashi, Koga, Tomohiro, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Ueki, Yukitaka, Yoshitama, Tamami, Eiraku, Nobutaka, Matsuoka, Naoki, Okada, Akitomo, Fujikawa, Keita, Otsubo, Hideo, Takaoka, Hirokazu, Hamada, Hiroaki, Tsuru, Tomomi, Nagano, Shuji, Yojiro, Arinobu, Hidaka, Toshihiko, Tada, Yoshifumi, and Kawakami, Atsushi

Published
2021
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29. Immunoglobulin G4-related Disease with Marked Eosinophilia: A Case Report and Literature Review

Author

Origuchi, Tomoki, primary, Uchida, Tomohisa, additional, Sakaguchi, Tatsuki, additional, Matsuo, Haruna, additional, Michitsuji, Toru, additional, Umeda, Masataka, additional, Shimizu, Toshimasa, additional, Koga, Tomohiro, additional, Kawashiri, Shin-Ya, additional, Iwamoto, Naoki, additional, Ichinose, Kunihiro, additional, Tamai, Mami, additional, Ichinose, Masahiro, additional, Ando, Koji, additional, Horie, Ichiro, additional, Nakao, Nobuhiro, additional, Irie, Junji, additional, and Kawakami, Atsushi, additional

Published
2023
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30. Seasonal Influence on Development of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: A Retrospective Cohort Study Conducted at Multiple Institutions in Japan (J-CANVAS)

Author

Yoshida, Yusuke, primary, Nakamoto, Naoki, additional, Oka, Naoya, additional, Kidoguchi, Genki, additional, Hosokawa, Yohei, additional, Araki, Kei, additional, Ishitoku, Michinori, additional, Watanabe, Hirofumi, additional, Sugimoto, Tomohiro, additional, Mokuda, Sho, additional, Kida, Takashi, additional, Yajima, Nobuyuki, additional, Omura, Satoshi, additional, Nakagomi, Daiki, additional, Abe, Yoshiyuki, additional, Kadoya, Masatoshi, additional, Takizawa, Naoho, additional, Nomura, Atsushi, additional, Kukida, Yuji, additional, Kondo, Naoya, additional, Yamano, Yasuhiko, additional, Yanagida, Takuya, additional, Endo, Koji, additional, Matsui, Kiyoshi, additional, Takeuchi, Tohru, additional, Ichinose, Kunihiro, additional, Kato, Masaru, additional, Yanai, Ryo, additional, Matsuo, Yusuke, additional, Shimojima, Yasuhiro, additional, Nishioka, Ryo, additional, Okazaki, Ryota, additional, Takata, Tomoaki, additional, Ito, Takafumi, additional, Moriyama, Mayuko, additional, Takatani, Ayuko, additional, Miyawaki, Yoshia, additional, Ito-Ihara, Toshiko, additional, Kawaguchi, Takashi, additional, Kawahito, Yutaka, additional, and Hirata, Shintaro, additional

Published
2023
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31. Comparison of complete renal response and mortality in early- and late-onset lupus nephritis: a multicenter retrospective study of a Japanese cohort

Author

Ichinose, Kunihiro, Kitamura, Mineaki, Sato, Shuntaro, Fujikawa, Keita, Horai, Yoshiro, Matsuoka, Naoki, Tsuboi, Masahiko, Nonaka, Fumiaki, Shimizu, Toshimasa, Sumiyoshi, Remi, Koga, Tomohiro, Kawashiri, Shin-ya, Iwamoto, Naoki, Igawa, Takashi, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Nishino, Tomoya, and Kawakami, Atsushi

Published
2020
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32. Comparison of lung microbiota between antineutrophil cytoplasmic antibody-associated vasculitis and sarcoidosis

Author

Fukui, Shoichi, Morimoto, Shimpei, Ichinose, Kunihiro, Nakashima, Shota, Ishimoto, Hiroshi, Hara, Atsuko, Kakugawa, Tomoyuki, Sakamoto, Noriho, Tsuji, Yoshika, Aramaki, Toshiyuki, Koga, Tomohiro, Kawashiri, Shin-ya, Iwamoto, Naoki, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Ueki, Yukitaka, Suzuki, Shino, Mukae, Hiroshi, and Kawakami, Atsushi

Published
2020
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33. Interleukin-18 and fibroblast growth factor 2 in combination is a useful diagnostic biomarker to distinguish adult-onset Still’s disease from sepsis

Author

Koga, Tomohiro, Sumiyoshi, Remi, Furukawa, Kaori, Sato, Shuntaro, Migita, Kiyoshi, Shimizu, Toshimasa, Umeda, Masataka, Endo, Yushiro, Fukui, Shoichi, Kawashiri, Shin-ya, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Nonaka, Fumiaki, Yachie, Akihiro, Kondo, Hideaki, Maeda, Takahiro, and Kawakami, Atsushi

Published
2020
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36. Serum levels of fibroblast growth factor-2 distinguish Takayasu arteritis from giant cell arteritis independent of age at diagnosis

Author

Fukui, Shoichi, Kuwahara-Takaki, Ayako, Ono, Nobuyuki, Sato, Shuntaro, Koga, Tomohiro, Kawashiri, Shin-ya, Iwanaga, Nozomi, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Migita, Kiyoshi, Arinobu, Yojiro, Niiro, Hiroaki, Tada, Yoshifumi, Akashi, Koichi, Maeda, Takahiro, and Kawakami, Atsushi

Published
2019
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37. Eosinophilic granulomatous with polyangiitis complicated by swelling of the oral cavity floor and cervical soft tissue as initial manifestation mimicking IgG4-related disease: A case report.

Author

Suzuki, Tomoko, Moriyama, Mayuko, Takano, Ikuko, Miyajima, Nobue, Yoshioka, Yuki, Honda, Manabu, Kondo, Masahiro, Shokei, Sachiko, Araki, Asuka, Kadota, Kyuichi, and Ichinose, Kunihiro

Subjects
EDEMA, CHURG-Strauss syndrome, PULMONARY eosinophilia, TISSUES, KIMURA disease, LEUKOCYTE count
Published
2024
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38. Association between hypogammaglobulinaemia and severe infections during induction therapy in ANCA-associated vasculitis: from J-CANVAS study.

Author

Omura, Satoshi, Kida, Takashi, Noma, Hisashi, Sunaga, Atsuhiko, Kusuoka, Hiroaki, Kadoya, Masatoshi, Nakagomi, Daiki, Abe, Yoshiyuki, Takizawa, Naoho, Nomura, Atsushi, Kukida, Yuji, Kondo, Naoya, Yamano, Yasuhiko, Yanagida, Takuya, Endo, Koji, Hirata, Shintaro, Matsui, Kiyoshi, Takeuchi, Tohru, Ichinose, Kunihiro, and Kato, Masaru

Subjects
IMMUNOGLOBULINS, CONFIDENCE intervals, MULTIVARIATE analysis, AUTOIMMUNE diseases, ANTINEUTROPHIL cytoplasmic antibodies, RETROSPECTIVE studies, INFECTION, COMPARATIVE studies, AGAMMAGLOBULINEMIA, DESCRIPTIVE statistics, RESEARCH funding, IMMUNOSUPPRESSIVE agents, STATISTICAL models, VASCULITIS, INDUCTION chemotherapy, LONGITUDINAL method
Abstract

Objectives To investigate the association between decreased serum IgG levels caused by remission-induction immunosuppressive therapy of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) and the development of severe infections. Methods We conducted a retrospective cohort study of patients with new-onset or severe relapsing AAV enrolled in the J-CANVAS registry, which was established at 24 referral sites in Japan. The minimum serum IgG levels up to 24 weeks and the incidence of severe infection up to 48 weeks after treatment initiation were evaluated. After multiple imputations for all explanatory variables, we performed the multivariate analysis using a Fine–Gray model to assess the association between low IgG (the minimum IgG levels <500 mg/dl) and severe infections. In addition, the association was expressed as a restricted cubic spline (RCS) and analysed by treatment subgroups. Results Of 657 included patients (microscopic polyangiitis, 392; granulomatosis with polyangiitis, 139; eosinophilic granulomatosis with polyangiitis, 126), 111 (16.9%) developed severe infections. The minimum serum IgG levels were measured in 510 patients, of whom 77 (15.1%) had low IgG. After multiple imputations, the confounder-adjusted hazard ratio of low IgG for the incidence of severe infections was 1.75 (95% confidence interval: 1.03–3.00). The RCS revealed a U-shaped association between serum IgG levels and the incidence of severe infection with serum IgG 946 mg/dl as the lowest point. Subgroup analysis showed no obvious heterogeneity between treatment regimens. Conclusion Regardless of treatment regimens, low IgG after remission-induction treatment was associated with the development of severe infections up to 48 weeks after treatment initiation. [ABSTRACT FROM AUTHOR]

Published
2023
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41. CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease

Author

Maeda, Kayaho, Otomo, Kotaro, Yoshida, Nobuya, Abu-Asab, Mones S., Ichinose, Kunihiro, Nishino, Tomoya, Kono, Michihito, Ferretti, Andrew, Bhargava, Rhea, Maruyama, Shoichi, Bickerton, Sean, Fahmy, Tarek M., Tsokos, Maria G., and Tsokos, George C.

Subjects
Autoimmune diseases -- Care and treatment -- Research, GTPases -- Analysis, Kidney diseases -- Care and treatment -- Development and progression -- Research, Lipopolysaccharides -- Analysis, Nephritis -- Research, Health care industry
Abstract

Podocyte malfunction occurs in autoimmune and nonautoimmune kidney disease. Calcium signaling is essential for podocyte injury, but the role of [Ca.sup.2+]/calmodulin-dependent kinase (CaMK) signaling in podocytes has not been fully explored. We report that podocytes from patients with lupus nephritis and focal segmental glomerulosclerosis and lupusprone and lipopolysaccharide- or adriamycin-treated mice display increased expression of CaMK IV (CaMK4), but not CaMK2. Mechanistically, CaMK4 modulated podocyte motility by altering the expression of the GTPases Rac1 and RhoA and suppressed the expression of nephrin, synaptopodin, and actin fibers in podocytes. In addition, it phosphorylated the scaffold protein 14-3-3[beta], which resulted in the release and degradation of synaptopodin. Targeted delivery of a CaMK4 inhibitor to podocytes preserved their ultrastructure, averted immune complex deposition and crescent formation, and suppressed proteinuria in lupus-prone mice and proteinuria in mice exposed to lipopolysaccharide-induced podocyte injury by preserving nephrin/synaptopodin expression. In animals exposed to adriamycin, podocyte- specific delivery of a CaMK4 inhibitor prevented and reversed podocyte injury and renal disease. We conclude that CaMK4 is pivotal in immune and nonimmune podocyte injury and that its targeted cell-specific inhibition preserves podocyte structure and function and should have therapeutic value in lupus nephritis and podocytopathies, including focal segmental glomerulosclerosis., Introduction Podocyte dysfunction is a common feature of renal injury in autoimmune and nonautoimmune renal diseases, including lupus nephritis (LN) and focal segmental glomerulosclerosis (FSGS). Sustained podocyte injury ultimately leads [...]

Published
2018
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42. Evaluation of a renal risk score for Japanese patients with ANCA-associated glomerulonephritis in a multi-center cohort study

Author

Uchida, Tomohisa, Ichinose, Kunihiro, Yamashita, Ayuko, Muta, Kumiko, Kitamura, Mineaki, Sato, Shuntaro, Iwamoto, Naoki, Nishino, Tomoya, Kawakami, Atsushi, Uchida, Tomohisa, Ichinose, Kunihiro, Yamashita, Ayuko, Muta, Kumiko, Kitamura, Mineaki, Sato, Shuntaro, Iwamoto, Naoki, Nishino, Tomoya, and Kawakami, Atsushi

Abstract

Background: In patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis, prediction of renal survival should guide the choice of therapy, but a prediction of the histological classification has inconsistencies. Objectives: To evaluate the usefulness of renal risk score (RRS) for Japanese patients with ANCA-associated glomerulonephritis (AAGN) and compare the prediction for end-stage renal disease (ESRD) between RRS and the histological classification. Methods: We retrospectively analyzed 96 patients with AAGN who underwent a renal biopsy. Renal survival was categorized by RRS, and the histological classification was assessed separately. We compared the predictive values for RRS and the histological classification. Results: The median observational period was 37.5 (interquartile range [IQR] 21.5–77.0) months. The median RRS point at the time of renal biopsy was 2 (IQR 0–7.8), and the patients were categorized into low- (n = 29), medium- (n = 43), and high-risk groups (n = 24) using RRS. As expected, the renal prognosis was the worst in the “high-risk” group and the best in the “low-risk” group. In the histological classification, the survival deteriorated progressively from “focal” (best) to “mixed,” “crescentic,” and “sclerotic” (worst) classes, different from the order in the original proposal for this system. Multivariable Cox regression analysis revealed that RRS was independently associated with ESRD. The difference in prediction for renal survival between RRS and the histological classification was not significant using area under receiver-operatingcharacteristic curves. Conclusion: We evaluated the usefulness of RRS in Japanese patients with AAGN and found it a stable predictor of renal survival in such patients., Frontiers in Immunology, 14, art. no. 1141407; 2023

Published
2023

47. Association of alcohol consumption and fatigue in SLE: A cross-sectional study from Lupus Registry of Nationwide Institution (LUNA) cohort

Author

Katayama, Yu, primary, Miyawaki, Yoshia, additional, Shidahara, Kenta, additional, Nawachi, Shoichi, additional, Asano, Yosuke, additional, Ohashi, Keiji, additional, Katsuyama, Eri, additional, Katsuyama, Takayuki, additional, Narazaki, Mariko, additional, Matsumoto, Yoshinori, additional, Sada, Ken-Ei, additional, Yajima, Nobuyuki, additional, Shimojima, Yasuhiro, additional, Yoshimi, Ryusuke, additional, Ichinose, Kunihiro, additional, Kajiyama, Hiroshi, additional, Fujiwara, Michio, additional, Sato, Shuzo, additional, and Wada, Jun, additional

Published
2023
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48. Immune complexome analysis of a rich variety of serum immune complexes identifies disease-characteristic immune complex antigens in systemic sclerosis

Author

Kutsuna, Yuki Jimbayashi, primary, Iwamoto, Naoki, additional, Ichinose, Kunihiro, additional, Aibara, Nozomi, additional, Nakashima, Katsumi, additional, Nakamura, Hideki, additional, Koike, Yuta, additional, Murota, Hiroyuki, additional, Ueki, Yukitaka, additional, Miyamoto, Hirotaka, additional, Hashizume, Junya, additional, Kodama, Yukinobu, additional, Nakashima, Mikiro, additional, Kawakami, Atsushi, additional, and Ohyama, Kaname, additional

Published
2023
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49. Musculoskeletal manifestations occur predominantly in patients with later-onset familial Mediterranean fever: Data from a multicenter, prospective national cohort study in Japan

Author

Endo, Yushiro, Koga, Tomohiro, Ishida, Midori, Fujita, Yuya, Tsuji, Sosuke, Takatani, Ayuko, Shimizu, Toshimasa, Sumiyoshi, Remi, Igawa, Takashi, Umeda, Masataka, Fukui, Shoichi, Nishino, Ayako, Kawashiri, Shin-ya, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Agematsu, Kazunaga, Yachie, Akihiro, Masumoto, Junya, Migita, Kiyoshi, and Kawakami, Atsushi

Published
2018
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50. Association of one-point glucocorticoid-free status with chronic damage and disease duration in systemic lupus erythematosus: a cross-sectional study

Author

Sada, Ken-ei, primary, Katayama, Yu, additional, Asano, Yosuke, additional, Hayashi, Keigo, additional, Miyawaki, Yoshia, additional, Ohashi, Keiji, additional, Katsuyama, Eri, additional, Katsuyama, Takayuki, additional, Takano-Narazaki, Mariko, additional, Matsumoto, Yoshinori, additional, Yoshimi, Ryusuke, additional, Shimojima, Yasuhiro, additional, Ohno, Shigeru, additional, Kajiyama, Hiroshi, additional, Ichinose, Kunihiro, additional, Sato, Shuzo, additional, Fujiwara, Michio, additional, and Yajima, Nobuyuki, additional

Published
2022
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