40 results on '"Ibrahim Maman Laminou"'
Search Results
2. Plasmodium falciparum kelch13 polymorphisms identified after treatment failure with artemisinin-based combination therapy in Niger
- Author
-
Ibrahima Issa Arzika, Neil F. Lobo, Mahaman Moustapha Lamine, Ilagouma Amadou Tidjani, Houzé Sandrine, Véronique Sarrasin-Hubert, Aboubacar Mahamadou, Eric Adehossi, Demba Sarr, Ousman Mahmud, and Ibrahim Maman Laminou
- Subjects
P. falciparum ,Resistance ,Artemisinin ,Pfkelch13 ,Niger ,Arctic medicine. Tropical medicine ,RC955-962 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Artemisinin-based combination therapy (ACT) is the most effective treatment for malaria, and has significantly reduced morbimortality. Polymorphisms associated with the Plasmodium falciparum Kelch gene (Pfkelch13) have been associated with delayed parasite clearance even with ACT treatment. Methods The Pfkelch13 gene was sequenced from P. falciparum infected patients (n = 159) with uncomplicated malaria in Niger. An adequate clinical and parasitological response (ACPR) was reported in 155 patients. Four (n = 4) patients had treatment failure (TF) that were not reinfections—two of which had late parasitological failures (LPF) and two had late clinical failures (LCF). Results Thirteen single nucleotide polymorphisms (SNPs) were identified of which seven were non-synonymous (C469R, T508S, R515T, A578S, I465V, I437V, F506L,), and three were synonymous (P443P, P715P, L514L). Three SNP (C469R, F506L, P715P) were present before ACT treatment, while seven mutations (C469R, T508S, R515T, L514L, P443P, I437V, I465V) were selected by artemether/lumefantrine (AL)—five of which were non-synonymous (C469R, T508S, R515T, I437V, I465V). Artesunate/amodiaquine (ASAQ) has selected any mutation. One sample presented three cumulatively non-synonymous SNPs—C469R, T508S, R515T. Conclusions This study demonstrates intra-host selection of Pfkelch13 gene by AL. The study highlights the importance of LCF and LPF parasites in the selection of resistance to ACT. Further studies using gene editing are required to confirm the potential implication of resistance to ACT with the most common R515T and T508S mutations. It would also be important to elucidate the role of cumulative mutations.
- Published
- 2023
- Full Text
- View/download PDF
3. Countrywide insecticide resistance monitoring and first report of the presence of the L1014S knock down resistance in Niger, West Africa
- Author
-
Hadiza Soumaila, Boubé Hamani, Ibrahim Issa Arzika, Amadou Soumana, Abdoulaye Daouda, Fatoumata Abdoulaye Daouda, Souleymane Mahaman Iro, Samira Gouro, Maman Sani Zaman-Allah, Izamné Mahamadou, Saadou Kadri, Noura Maman Salé, Wilfried Hounkanrin, Boubacar Mahamadou, Halima Naroua Zamaka, Rabiou Labbo, Ibrahim Maman Laminou, Hadiza Jackou, Sabiti Idrissa, Eric Coulibaly, Zilahatou Bahari-Tohon, Els Mathieu, Jenny Carlson, Ellen Dotson, Taiwo Samson Awolola, Cecilia Flatley, and Joseph Chabi
- Subjects
Insecticide resistance ,Resistance mechanisms ,New generation ITNs ,Malaria ,Niger ,Arctic medicine. Tropical medicine ,RC955-962 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Mass distribution of insecticide-treated nets (ITNs) is the principal malaria vector control strategy adopted by Niger. To better inform on the most appropriate ITN to distribute, the National Malaria Control Programme (NMCP) of Niger and its partners, conducted insecticide resistance monitoring in selected sites across the country. Methods The susceptibility of Anopheles gambiae sensu lato (s.l.) to chlorfenapyr and pyrethroid insecticides was investigated in a total of sixteen sites in 2019 and 2020, using 2–5-day-old adults reared from wild collected larvae per site. The susceptibility status, pyrethroid resistance intensity at 5 and 10 times the diagnostic concentrations, and piperonyl butoxide (PBO) synergism with diagnostic concentrations of deltamethrin, permethrin and alpha-cypermethrin were assessed using WHO bioassays. Two doses (100 and 200 µg/bottle) of chlorfenapyr were tested using the CDC bottle assay method. Species composition and allele frequencies for knock-down resistance (kdr-L1014F and L1014S) and acetylcholinesterase (ace-1 G119S) mutations were further characterized using polymerase chain reaction (PCR). Results High resistance intensity to all pyrethroids tested was observed in all sites except for alpha-cypermethrin in Gaya and Tessaoua and permethrin in Gaya in 2019 recording moderate resistance intensity. Similarly, Balleyara, Keita and Tillabery yielded moderate resistance intensity for alpha-cypermethrin and deltamethrin, and Niamey V low resistance intensity against deltamethrin and permethrin in 2020. Pre-exposure to PBO substantially increased susceptibility with average increases in mortality between 0 and 70% for tested pyrethroids. Susceptibility to chlorfenapyr (100 µg/bottle) was recorded in all sites except in Tessaoua and Magaria where susceptibility was recorded at the dose of 200 µg/bottle. Anopheles coluzzii was the predominant malaria vector species in most of the sites followed by An. gambiae sensu stricto (s.s.) and Anopheles arabiensis. The kdr-L1014S allele, investigated for the first time, was detected in the country. Both kdr-L1014F (frequencies [0.46–0.81]) and L1014S (frequencies [0.41–0.87]) were present in all sites while the ace-1 G119S was between 0.08 and 0.20. Conclusion The data collected will guide the NMCP in making evidence-based decisions to better adapt vector control strategies and insecticide resistance management in Niger, starting with mass distribution of new generation ITNs such as interceptor G2 and PBO ITNs.
- Published
- 2022
- Full Text
- View/download PDF
4. Prevalence of Mutations in the Pfdhfr, Pfdhps, and Pfmdr1 Genes of Malarial Parasites Isolated from Symptomatic Patients in Dogondoutchi, Niger
- Author
-
Ibrahima Issa, Mahaman Moustapha Lamine, Veronique Hubert, Amadou Ilagouma, Eric Adehossi, Aboubacar Mahamadou, Neil F. Lobo, Demba Sarr, Lisa M. Shollenberger, Houze Sandrine, Ronan Jambou, and Ibrahim Maman Laminou
- Subjects
P. falciparum ,Pfdhfr ,Pfdhps ,Pfmdr1 ,Niger ,Medicine - Abstract
The effectiveness of artemisinin-based combination therapies (ACTs) depends not only on that of artemisinin but also on that of partner molecules. This study aims to evaluate the prevalence of mutations in the Pfdhfr, Pfdhps, and Pfmdr1 genes from isolates collected during a clinical study. Plasmodium genomic DNA samples extracted from symptomatic malaria patients from Dogondoutchi, Niger, were sequenced by the Sanger method to determine mutations in the Pfdhfr (codons 51, 59, 108, and 164), Pfdhps (codons 436, 437, 540, 581, and 613), and Pfmdr1 (codons 86, 184, 1034, and 1246) genes. One hundred fifty-five (155) pre-treatment samples were sequenced for the Pfdhfr, Pfdhps, and Pfmdr1 genes. A high prevalence of mutations in the Pfdhfr gene was observed at the level of the N51I (84.97%), C59R (92.62%), and S108N (97.39%) codons. The key K540E mutation in the Pfdhps gene was not observed. Only one isolate was found to harbor a mutation at codon I431V. The most common mutation on the Pfmdr1 gene was Y184F in 71.43% of the mutations found, followed by N86Y in 10.20%. The triple-mutant haplotype N51I/C59R/S108N (IRN) was detected in 97% of the samples. Single-mutant (ICS and NCN) and double-mutant (IRS, NRN, and ICN) haplotypes were prevalent at 97% and 95%, respectively. Double-mutant haplotypes of the Pfdhps (581 and 613) and Pfmdr (86 and 184) were found in 3% and 25.45% of the isolates studied, respectively. The study focused on the molecular analysis of the sequencing of the Pfdhfr, Pfdhps, and Pfmdr1 genes. Although a high prevalence of mutations in the Pfdhfr gene have been observed, there is a lack of sulfadoxine pyrimethamine resistance. There is a high prevalence of mutation in the Pfmdr184 codon associated with resistance to amodiaquine. These data will be used by Niger’s National Malaria Control Program to better monitor the resistance of Plasmodium to partner molecules in artemisinin-based combination therapies.
- Published
- 2022
- Full Text
- View/download PDF
5. Infection palustre de la femme enceinte à Niamey au Niger
- Author
-
Zara Maman Oumarou, Mahaman Moustapha Lamine, Tahirou Issaka, Kamayé Moumouni, Ibrahim Alkassoum, Daou Maman, Mahamadou Doutchi, Soumana Alido, and Ibrahim Maman Laminou
- Subjects
paludisme ,femme enceinte ,signes cliniques ,facteurs de risque ,niger ,Medicine - Abstract
INTRODUCTION: Le paludisme chez la femme enceinte est problème majeur de santé public en Afrique. Il a des conséquences graves aussi bien sur la mère, le fœtus que le nouveau-né. Il est responsable d´un fort taux de morbi-mortalité maternelle et infantile. L´objectif de l´étude est de déterminer la prévalence de l´infection plasmodiale chez la femme enceinte, décrire ses signes cliniques et ses complications éventuelles, analyser les facteurs associés et proposer des mesures de prévention. METHODES: il s´agit d´une étude transversale, conduite du 1er Juin au 30 Novembre 2017 à la Maternité Issaka Gazobi (MIG) de Niamey. Le diagnostic a été fait par microscopie. RESULTATS: deux cents quarante-neuf (249) femmes ont été incluses dans cette étude. La prévalence de l´infection plasmodiale était de 36,5% (IC95%; [30,6; 42,9]). La densité parasitaire moyenne était de 177 P/µl (DS: 121; [40; 800]). Toutes les infections étaient à P.falciparum. 73,6% (67/91) des femmes infectées étaient asymptomatiques. Seules 26,4% (24/91) ont fait un paludisme non compliqué. 9,6% (6/91) ont avorté. 38,4% des nouveau-nés avaient un faible poids à la naissance. 26,51% (66/249) ont développé un paludisme congénital. Le taux de létalité était de 1,1% (1/91). Le traitement préventif intermittent (TPI) protège significativement contre le paludisme gestationnel (p=0,01). CONCLUSION: l´infection des femmes enceintes par le P.falciparum est très fréquente au Niger. Ce portage est le plus souvent asymptomatique mais peut évoluer vers un paludisme non compliqué ou même sévère. Les principales conséquences sont l´avortement, le faible poids à la naissance, le retard de croissance intra utero, le paludisme congénital et le décès maternel. Le TPI et l´utilisation de la moustiquaire imprégnée d´insecticide à longue durée d´action (MILDA) permettent de prévenir l´infection.
- Published
- 2020
- Full Text
- View/download PDF
6. Efficacy of artesunate–amodiaquine, dihydroartemisinin–piperaquine and artemether–lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Maradi, Niger
- Author
-
Francesco Grandesso, Ousmane Guindo, Lynda Woi Messe, Rockyath Makarimi, Aliou Traore, Souleymane Dama, Ibrahim Maman Laminou, Jean Rigal, Martin de Smet, Odile Ouwe Missi Oukem-Boyer, Ogobara K. Doumbo, Abdoulaye Djimdé, and Jean-François Etard
- Subjects
Malaria ,Efficacy ,Antimalarial ,Artemisinin ,Resistance ,Parasite clearance ,Arctic medicine. Tropical medicine ,RC955-962 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Malaria endemic countries need to assess efficacy of anti-malarial treatments on a regular basis. Moreover, resistance to artemisinin that is established across mainland South-East Asia represents today a major threat to global health. Monitoring the efficacy of artemisinin-based combination therapies is of paramount importance to detect as early as possible the emergence of resistance in African countries that toll the highest burden of malaria morbidity and mortality. Methods A WHO standard protocol was used to assess efficacy of the combinations artesunate–amodiaquine (AS–AQ Winthrop®), dihydroartemisinin–piperaquine (DHA–PPQ, Eurartesim®) and artemether–lumefantrine (AM–LM, Coartem®) taken under supervision and respecting pharmaceutical recommendations. The study enrolled for each treatment arm 212 children aged 6–59 months living in Maradi (Niger) and suffering with uncomplicated falciparum malaria. The Kaplan–Meier 42-day PCR-adjusted cure rate was the primary outcome. A standardized parasite clearance estimator was used to assess delayed parasite clearance as surrogate maker of suspected artemisinin resistance. Results No early treatment failures were found in any of the study treatment arms. The day-42 PCR-adjusted cure rate estimates were 99.5, 98.4 and 99.0% in the AS–AQ, DHA–PPQ and AM–LM arms, respectively. The reinfection rate (expressed also as Kaplan–Meier estimates) was higher in the AM–LM arm (32.4%) than in the AS–AQ (13.8%) and the DHA–PPQ arm (24.9%). The parasite clearance rate constant was 0.27, 0.26 and 0.25 per hour for AS–AQ, DHA–PPQ and AM–LM, respectively. Conclusions All the three treatments evaluated largely meet WHO criteria (at least 95% efficacy). AS–AQ and AL–LM may continue to be used and DHA–PPQ may be also recommended as first-line treatment for uncomplicated falciparum malaria in Maradi. The parasite clearance rate were consistent with reference values indicating no suspected artemisinin resistance. Nevertheless, the monitoring of anti-malarial drug efficacy should continue. Trial registration details Registry number at ClinicalTrial.gov: NCT01755559
- Published
- 2018
- Full Text
- View/download PDF
7. Transfusional Malaria and Associated Factors at the National Blood Transfusion Center of Niamey-Niger
- Author
-
Aminata Iro, Moustapha Mahamane Lamine, Ramatoulaye Hamidou Lazoumar, Ibrahim Alkassoum, Daou Maman, Harouna Amadou Mahaman Laouali, Mahamadou Doutchi, Seydou Maiguizo, and Ibrahim Maman Laminou
- Subjects
Arctic medicine. Tropical medicine ,RC955-962 - Abstract
Summary. Problem. Transfusional malaria is an accidental transmission of Plasmodium via a blood transfusion. Its magnitude is underestimated and very little data on the assessment of this risk are available in Niger. Objective. This study aimed to determine the prevalence of plasmodial infection of blood bags at the National Blood Transfusion Center of Niamey (NBTC). Methodology. A cross-sectional study to diagnose Plasmodium infection by microscopy and Rapid Diagnostic Test (RDT) was carried out during the rainy season (September to November 2015). Blood grouping was performed by the BETH-VINCENT technique. Results. One thousand three hundred and fifty-seven (1357) blood bags were collected. One hundred and fifty-seven (11.6%) of the donors were infected with Plasmodium by microscopy and 2.4% (9/369) by rapid diagnostic test. All infections were with P. falciparum (100%). The mean parasite density was 197 parasites/μL (SD=281; [80: 2000]). There were no significant differences in infection prevalence between the ABO blood groups (p=0.3) or the rhesus positivity (p=08). There is also no significant difference in temporal (p=0.1) and spatial (p=0.6) distribution. Conclusion. The transmission of transfusional malaria during the rainy season is a fact in Niger. Such risks were independent of the ABO blood type and positivity for the rhesus antigen. Pretransfusion diagnosis or posttransfusion therapy should be instituted to prevent it.
- Published
- 2019
- Full Text
- View/download PDF
8. A Report of Four Cases of Blackwater Fever after Quinine Treatment at Zinder National Hospital, Niger Republic
- Author
-
Doutchi Mahamadou, Diongolé M. Hassane, Moussa Tondi Maiga Zeinabou, Iliassou Aboubacar, Ali Osseini, Adamou Harissou, Garba Abdoul-Aziz, Alkassoum Ibrahim, Ibrahim Maman Laminou, and Adéhossi Eric
- Subjects
Infectious and parasitic diseases ,RC109-216 - Abstract
Background. Blackwater fever (BWF) is a rare but serious complication of malaria that is a consequence of antimalarial treatment. Its prevalence seems to have increased. Its diagnosis is based on clinical symptoms and urine color. We report on 4 BWF cases admitted to the infectious diseases department of Zinder National Hospital. Results. Four patients were hospitalized in September 2017 for a hepatorenal syndrome of jaundice, port wine-colored urine, renal failure, and hepatic cytolysis following antimalarial treatment with quinine salts. Quinine treatment was stopped and treatment was continued with injectable artemether. Three patients underwent extra-renal purification. Their evolution was favorable. One patient died less than 24 hours after admission. Conclusion. A rare and severe complication, blackwater fever must be considered for patients under antimalarial treatment who present with jaundice, abdominal pain, and acute renal insufficiency with port wine-colored urine. Rapid diagnosis and management in an intensive care unit are crucial for improving the prognosis.
- Published
- 2019
- Full Text
- View/download PDF
9. Evidence that seasonal malaria chemoprevention with SPAQ influences blood and pre-erythrocytic stage antibody responses of Plasmodium falciparum infections in Niger
- Author
-
Mahaman Moustapha, Lamine, Adamou, Rafiou, Ibrahim, Maman Laminou, Abdoulaye Louis Padounou, Mariama, Diallo, Abdoulaye, Courtin, David, Testa, Jean, and Ndiaye, Jean LouisAbdourahim
- Published
- 2021
- Full Text
- View/download PDF
10. Management of Risk Factors for Health Care Workers After Initial Contact with Patients Infected with SARS-COV-2 in Niamey, The Center of the Epidemic in Niger
- Author
-
Hamidou Lazoumar Ramatoulaye, Aliou Sanda Abdal-Kader, Adamou Lagare, Mahamadou A Maiga, Fakani Aboutalib Aliane, François Comlan Aida Sylviane, Idi Issa, Bibata Abdou Sidikou, Garda Idé Oumarou, Ali sidiki, Zeinabou Abdou Aouta, Amina Moussa, Zeinabou Dioffo Alassan, Ibrahim Karidjo, Goni Alhassan Maman Bachir, Issifou Djibo, Salia Moussa, Ibrahim Maman Laminou, and Ronan Jambou
- Abstract
BackgroundThe covid-19 pandemic is caused by a new corona virus called SARS Cov-2. Health care workers are particularly exposed target.Aimthis study aims to analyze the risk factors of SARS-Cov-2 infection in health workers who have been in contact with positive patient.MethodsThis is a prospective cohort conducted among health workers from March 2022 to January 2021 in health care facilities in Niamey. A questionnaire was administrated at inclusion. rRT-PCR was performed if clinical signs were present. ELISA testing was performed at baseline, day15 and day 30. The chi-square or Fisher test, Kaplan-Meir survival model, Cow regression and logistic regression were used as statistical test.Results259 health workers were included. More than half of the respondents were female. 45.95% of the participants were nurses and 36.68% were physicians. The prevalence of Covid-19 was 28.8%. 56.4% of the participants had positive serology at day 30. The risk factors associated with Covid-19 were professional category (p=0.024). Membership structure (pConclusionComorbidities, function and affiliation are the main risk factors for Covid-19 and hand hygiene is a protective factor.
- Published
- 2023
11. Plasmodium falciparum Kelch13 polymorphisms identified after treatment failure with artemisinin- based combination therapy in Niger
- Author
-
Ibrahima Issa Arzika, Neil Lobo, Mahaman Moustapha Lamine, Ilagouma Amadou Tidjani, Sandrine Houze, Véronique Hubert, Boubacar Mahamadou, Eric Adehossi, Demba Sarr, Ousman Mahmud, and Ibrahim Maman Laminou
- Abstract
Background: Artemisinin-based combination therapy (ACT) is the most effective treatment for malaria, and has significantly reduced morbimortality. Polymorphisms associated with the Plasmodium falciparum kelch gene (Pfkelch13) propeller domains have been associated with delayed parasite clearance even with ACT treatment. Methods: The Pfkelch13gene was sequenced from P. falciparum infected patients (n=159) with uncomplicated malaria in Niger.An adequate clinical and parasitological response (ACPR) was reported in 155 patients. Four (n=4) patients had treatment failure (TF) that were not reinfections - two of which had late parasitological failures (LPF) and two had late clinical failures (LCF). Results: Thirteen single nucleotide polymorphisms (SNPs) were identified of which eight were non synonymous (NSY) (C469R, T508S, S515T, A578S, I465V, I437V, E506L, N197D), and five were synonymous (SY) (H298H, H385H, P443P, P715P, L514L). Six SNP (C469R, H298H, E506L, N197D, H385H, P715P) were present before ACT treatment, while seven mutations (C469R, T508S, S515T, L514L, P443P, I437V, I465V) were selected by Artemether lumefantrine (AL) - five of which were non synonymous (C469R, T508S, S515T, I437V, I465V). Artesunate amodiaquine (ASAQ) has selected any mutation. One sample presented three cumulatively non-synonymous SNPs - C469R, T508S, S515T. This study demonstrates intra host selection of Pfkelch13 gene NS by AL. Conclusions: The study highlights the importance of LCF and LPF parasites in the selection of resistance to ACT. Further studies using gene editing are required to confirm the potential implication of resistance to ACT with the most common S515T and T508S mutations. It would also be important to elucidate the role of cumulative mutations. GenBank accession numbers: MZ364160, MZ364-213
- Published
- 2022
12. Rage humaine et itinéraire médical au Niger: A propos d’un cas confirmé par RT- qPCR en 2019
- Author
-
Morou Mounkaila, Bayaki Saka, Gado Amadou Mahamadou, Lagaré Adamou, and Ibrahim Maman Laminou
- Published
- 2021
13. Sickle Cell Disease and Severity of Malaria
- Author
-
Ramatoulaye Hamidou Lazoumar, Djibo Yacouba Hamadou, Mansour Maman Anou, Mahamadou Doutchi, Mahamane Moustapha lamine, Samaila Boubacar, Maman Daou, Ibrahim Alkasoume, Ibrahim Maman Laminou, and Kamaye Moumouni
- Subjects
medicine.anatomical_structure ,business.industry ,Immunology ,Cell ,Medicine ,General Medicine ,Disease ,business ,medicine.disease ,Malaria - Published
- 2019
14. Infection palustre de la femme enceinte à Niamey au Niger
- Author
-
Tahirou Issaka, Mahaman Moustapha Lamine, Mahamadou Doutchi, Ibrahim Maman Laminou, Ibrahim Alkassoum, Soumana Alido, Daou Maman, Kamaye Moumouni, and Zara Maman Oumarou
- Subjects
Adult ,medicine.medical_specialty ,Paludisme ,femme enceinte ,030231 tropical medicine ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Pregnancy ,medicine ,Prevalence ,risk factors ,Humans ,030212 general & internal medicine ,Niger ,Malaria, Falciparum ,Gynecology ,Mosquito Nets ,business.industry ,Research ,Infant, Newborn ,General Medicine ,Infant, Low Birth Weight ,medicine.disease ,Malaria ,Abortion, Spontaneous ,Cross-Sectional Studies ,Paludisme, femme enceinte, signes cliniques, facteurs de risque, Niger ,Pregnancy Complications, Parasitic ,Female ,signes cliniques ,clinical signs ,business ,pregnant women ,facteurs de risque - Abstract
INTRODUCTION: Le paludisme chez la femme enceinte est un problA¨me majeur de santA© publique en Afrique. Il a des consA©quences graves aussi bien sur la mA¨re, le fA“tus que le nouveau-nA©. Il est responsable d´un fort taux de morbi-mortalitA© maternelle et infantile. L´objectif de l´A©tude est de dA©terminer la prA©valence de l´infection plasmodiale chez la femme enceinte, dA©crire ses signes cliniques et ses complications A©ventuelles, analyser les facteurs associA©s et proposer des mesures de prA©vention. METHODES: il s´agit d´une A©tude transversale, conduite du 1er juin au 30 novembre 2017 A la MaternitA© Issaka Gazobi (MIG) de Niamey. Le diagnostic a A©tA© fait par microscopie. RESULTATS: deux cents quarante-neuf (249) femmes ont A©tA© incluses dans cette A©tude. La prA©valence de l´infection plasmodiale A©tait de 36,5% (IC95%; [30,6; 42,9]). La densitA© parasitaire moyenne A©tait de 177 P/µl (DS: 121; [40; 800]). Toutes les infections A©taient A P.falciparum. Un peu plus de soixante-treize pourcent (73,6%) (67/91) des femmes infectA©es A©taient asymptomatiques. Seules 26,4% (24/91) ont fait un paludisme non compliquA©; 9,6% (6/91) ont avortA©; 38,4% des nouveau-nA©s avaient un faible poids A la naissance et 26,51% (66/249) ont dA©veloppA© un paludisme congA©nital. Le taux de lA©talitA© A©tait de 1,1% (1/91). Le traitement prA©ventif intermittent (TPI) protA¨ge significativement contre le paludisme gestationnel (p=0,01). CONCLUSION: l´infection des femmes enceintes par le P.falciparum est trA¨s frA©quente au Niger. Ce portage est le plus souvent asymptomatique mais peut A©voluer vers un paludisme non compliquA© ou mAame sA©vA¨re. Les principales consA©quences sont l´avortement, le faible poids A la naissance, le retard de croissance intra utero, le paludisme congA©nital et le dA©cA¨s maternel. Le TPI et l´utilisation de la moustiquaire imprA©gnA©e d´insecticide A longue durA©e d´action (MILDA) permettent de prA©venir l´infection.
- Published
- 2020
15. Trends in Pharmaceutical Research and Development Vol. 2
- Author
-
Khadijatul Qubra, M. C. S. Subha, K. Chowdoji Rao, S. S. Kuthar, Pamela Sinha, Krystal M. Rivera-Rodríguez, B. Mallikarjuna, K. Pallavi, Leticia Eligio-García, Ramatoulaye Hamidou Lazoumar, Márió Gajdács, Ruchika Nandha, V. V. Kovalev, Saad Mohamed Hussein Ayoub, T. I. Ivko, Moustapha Mahamane Lamine, V. Krishnaveni, Elida Pontifez-Pablo, S. V. Spyrydonov, Sharma Khemchand, Muna Abdel Latif Khalil, Chinky Goyal, L. O. Bobrytska, M. G. Hogade, Ibrahim Maman Laminou, L. Iakovlieva, Bisu Singh, Andrea Foglio Bonda, K. Madhusudana Rao, Daou Maman, T. A. Germanyuk, Lorella Giovannelli, Aminata Iro, Lorena Segale, Raúl H Morales-Borges, A. O. Adebola Yusuf, Kantha D. Arunachalam, Harouna Amadou Mahaman Laouali, Olena Koshova, Gupta Arun Kumar, Enedina Jiménez-Cardoso, Salud Pérez-Gutiérrez, Mahamadou Doutchi, Ibrahim Alkassoum, Seydou Maiguizo, Anatoly Gordienko, N. A. Gordzievska, O. Tkachova, and Harpal Singh
- Subjects
Engineering ,business.industry ,Engineering ethics ,Pharmaceutical sciences ,business - Published
- 2020
16. A Fatal Case of COVID-19 in an Infant with Severe Acute Malnutrition Admitted to a Paediatric Ward in Niger
- Author
-
Soumana, Alido, Samaila, Aboubacar, Moustapha, Lamine Mahaman, Kamaye, Moumouni, Daouda, Balkissa, Salifou, Ibrahim Alkassoum, Lagare, Adamou, Adehossi, Eric Omar, and Ibrahim, Maman Laminou
- Subjects
Article Subject - Abstract
While there have been very few fatal cases, SARS-CoV-2 has been reported in paediatric patients. This study aims to describe a fatal case of COVID-19 in a child with severe acute malnutrition. The eight-month-old child presented with fever, diarrhoea, and difficulty in breathing. The mother of the child had fever and shortness of breath four weeks before she died. Physical examination revealed lethargy, dehydration, and severe weight loss with a weight of 5 kg at a height of 78 cm tall. The weight-for-height index was less than three Z-scores, which corresponds to severe acute malnutrition. The pulmonary examination revealed moderate respiratory distress, and the chest X-ray presented features suggestive of pneumonia in the right lung area. In the context of the COVID-19 outbreak in Niger and the circumstances of the mother’s death, a nasal swab was taken for laboratory confirmation. Treatment provided to the child included intranasal oxygen, antibiotics, and a dietary program with therapeutic milk. The child died 48 hours after his admission. The history of contact with a SARS-CoV-2 suspect or positive patient should lead to screening for infection by using RT-PCR. It is important to investigate malnutrition as a potential risk factor for severe SARS-CoV-2 infection and resultant mortality.
- Published
- 2020
- Full Text
- View/download PDF
17. Detection of Plasmodium falciparum K13 Propeller A569G Mutation after Artesunate-amodiaquine Treatment Failure in Niger
- Author
-
Alioune Dieye, D. Gora, Ibrahim Maman Laminou, Boubacar Mahamadou, Moustapha Mahamane Lamine, and Ibrahim Arzika
- Subjects
Artemether/lumefantrine ,030231 tropical medicine ,Artesunate/amodiaquine ,Propeller ,Plasmodium falciparum ,General Medicine ,Biology ,medicine.disease ,biology.organism_classification ,Virology ,Treatment failure ,03 medical and health sciences ,0302 clinical medicine ,Mutation (genetic algorithm) ,medicine ,030212 general & internal medicine ,Malaria ,medicine.drug - Published
- 2018
18. Current Trends in Disease and Health Vol. 2
- Author
-
Mohammed Obied Altwerqi, Ruba Qadi, Ibrahim Alkasoum, Kamayé Moumouni, C. C. Ofoegbu, Ramatoulaye Hamidou Lazoumar, F. S. F. Alyazidi, Tomisin Matthew Adaja, Matilda Adesuwa O. Ojo, Ashwaq Mohammed Almalki, Amalsaleh Alsofyany, Nwabor Ozioma Forstinus, Rayan Khalid Almalki, Philip Pine Abata, Maman Daou, Michael Ira Reich, Ameenah Alkhaldi, Fatmahmeteb Alnufei, Vicente Beltrán-Campos, Qasemmuidh Alharthi, Djibo Yacouba Hamadou, Alicia Aboytes-Alvarez, C. O. Ifeadike, Xiomara Arteaga-Herrera, Charles C. Onoh, Martins Paul Emenike, Xóchitl Sofía Ramírez-Gómez, A. N. Onyeyili, Abdelaziz Mousa Thabet, Ani Ogonna Christiana, S. S. Adaramola, Samaila Boubacar, Mansour Mohammed Altwerqi, Nicolás Padilla-Raygoza, Sarah Binbaz, Ify L. Nwaogazie, V. C. Analo, Sarah Obaid Dhafar, Mahamane Moustapha lamine, Oghenefejiri Bovwe, Nnamonu Emmanuel Ikechukwu, Ken K. Umeadi, Amalturki Altowairqi, ThankGod C. Omuruka, Asim Ali Alzahrani, Mahamadou Doutchi, Victor Chuwang Pam, Amjad Althagafi, O. F. Emelumadu, Ma. Lourdes Jordan-Jinez, Verónica Benítez-Guerrero, P. E. N. Onyemachi, Ibrahim Maman Laminou, Celia Monserrat Bernal-Razon, Omar Ahmed Asiri, Mansour Maman Anou, Hosamtalal Mashrah, A. S. V. Prasad, Nawwafwaiel Aljuaid, Ernest I. Achalu, Majed Mansour Aljuaid, María Luisa Sánchez-Padilla, Georgina Olvera-Villanueva, Clarisee Noel Ayina Ayina, Sanaa S. Thabet, Terkaa Atim, Faisal Ali Alotaibi, Ozoofmatar Alghashmari, and Jonathan Abina Karshima
- Subjects
business.industry ,Environmental health ,Medicine ,Disease ,Current (fluid) ,business - Published
- 2019
19. Some evidence that seasonal malaria chemoprevention with SPAQ has an effect on blood stage antibody responses and pre-erythrocytic stage of Plasmodium falciparum infections in Niger.
- Author
-
Moustapha, Lamine Mahaman, primary, Adamou, Rafiou, additional, Ibrahim, Maman Laminou, additional, Padounou, Mariama Abdoulaye Louis, additional, Diallo, Abdoulaye, additional, Courtin, David, additional, Testa, Jean, additional, and NDiaye, Jean Louis, additional
- Published
- 2020
- Full Text
- View/download PDF
20. Infection palustre de la femme enceinte à Niamey au Niger
- Author
-
Oumarou, Zara Maman, primary, Lamine, Mahaman Moustapha, additional, Issaka, Tahirou, additional, Moumouni, Kamayé, additional, Alkassoum, Ibrahim, additional, Maman, Daou, additional, Doutchi, Mahamadou, additional, Alido, Soumana, additional, and Ibrahim, Maman Laminou, additional
- Published
- 2020
- Full Text
- View/download PDF
21. Teaching One Health: Animal husbandry in a post-graduate interdisciplinary curriculum
- Author
-
Sidikou, Djibo Idrissa, primary, Caron, Yannick, additional, Delguste, Catherine, additional, Ibrahim, Abdoulkarim Issa, additional, Ibrahim, Maman Laminou, additional, Adakal, Hassane, additional, Hornick, Jean-Luc, additional, and Antoine-Moussiaux, Nicolas, additional
- Published
- 2020
- Full Text
- View/download PDF
22. Some evidence that seasonal malaria chemoprevention with SPAQ did not have effect on antibodies response against pre-erythrocyte stage but on the blood-stage in Niger.
- Author
-
Moustapha, Lamine Mahaman, primary, Adamou, Rafiou, additional, Ibrahim, Maman Laminou, additional, Padounou, Mariama Abdoulaye Louis, additional, Diallo, Abdoulaye, additional, Courtin, David, additional, Testa, Jean, additional, and NDiaye, Jean Louis, additional
- Published
- 2019
- Full Text
- View/download PDF
23. Polymorphism of pfk13-propeller in Niger: Detection of Novel Mutations
- Author
-
Mahaman Moustapha Lamine, Oumou Ascofaré, Ibrahim Maman Laminou, Boubacar Mahamadou, and Alioune Dieye
- Subjects
Genetics ,03 medical and health sciences ,0302 clinical medicine ,Polymorphism (materials science) ,030231 tropical medicine ,030212 general & internal medicine ,General Medicine ,Biology - Published
- 2017
24. Advances and Trends in Biotechnology and Genetics Vol. 2
- Author
-
E. P. Willie, Farid Zaidi, Mukesh Kumar Patidar, Anil Kumar, Azab Elsayed Azab, Adaobi Mary-Joy Okafor, Sadhana Nighojkar, M. Senthilnathan, D. Gora, H. J. Bhosale, Sonia Medouni-Adrar, Sevastianos Roussos, Ibrahim Arzika, Adedeji David Atere, Edouard Kouamé N’Goran, Mohamed Omar Albasha, Antonio Mori, Michael O. Ozoje, Meeta Sharma, E. E. Ekerette, Tukaram Kadam, Véronique Desseaux, E. A. Okon, K.V.N.S. Srinivas, Nafan Diarrassouba, Hermann-Desiré Lallie, Giovanni Malerba, E. V. Ikpeme, Kelvin Ifeanyichukwu Egbuchulem, A. Ramadevi, Ayobola A. Iyanda, Anand Nighojkar, Franklin Kayode Ayenogun, Noel Dougba Dago, Ibrahim Maman Laminou, Boubacar Mahamadou, Lamia Medouni-Haroune, Martial Didier Yao Saraka, S. Z. Uzma, Alioune Dieye, Bolaji David Akinbo, H. E. Etta, A. Thangamani, Massimo Delledonne, Lamine Baba-Moussa, Mouloud Kecha, O. U. Udensi, and Moustapha Mahamane Lamine
- Subjects
Engineering ,business.industry ,Engineering ethics ,business - Published
- 2019
25. Transfusional Malaria and Associated Factors at the National Blood Transfusion Center of Niamey-Niger
- Author
-
Ibrahim Alkassoum, Seydou Maiguizo, Daou Maman, Ramatoulaye Hamidou Lazoumar, Mahamadou Doutchi, Aminata Iro, Harouna Amadou Mahaman Laouali, Moustapha Mahamane Lamine, and Ibrahim Maman Laminou
- Subjects
medicine.medical_specialty ,lcsh:Arctic medicine. Tropical medicine ,Blood transfusion ,Article Subject ,lcsh:RC955-962 ,medicine.medical_treatment ,030231 tropical medicine ,Microbiology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,ABO blood group system ,parasitic diseases ,medicine ,030212 general & internal medicine ,Parasite density ,Rapid diagnostic test ,business.industry ,Transmission (medicine) ,Infection prevalence ,General Medicine ,medicine.disease ,Blood grouping ,Parasitology ,business ,Malaria ,Research Article - Abstract
Summary.Problem. Transfusional malaria is an accidental transmission ofPlasmodiumvia a blood transfusion. Its magnitude is underestimated and very little data on the assessment of this risk are available in Niger.Objective. This study aimed to determine the prevalence of plasmodial infection of blood bags at the National Blood Transfusion Center of Niamey (NBTC).Methodology. A cross-sectional study to diagnosePlasmodiuminfection by microscopy and Rapid Diagnostic Test (RDT) was carried out during the rainy season (September to November 2015). Blood grouping was performed by the BETH-VINCENT technique.Results. One thousand three hundred and fifty-seven (1357) blood bags were collected. One hundred and fifty-seven (11.6%) of the donors were infected withPlasmodiumby microscopy and 2.4% (9/369) by rapid diagnostic test. All infections were withP. falciparum(100%). The mean parasite density was 197 parasites/μL (SD=281; [80: 2000]). There were no significant differences in infection prevalence between the ABO blood groups (p=0.3) or the rhesus positivity (p=08). There is also no significant difference in temporal (p=0.1) and spatial (p=0.6) distribution.Conclusion. The transmission of transfusional malaria during the rainy season is a fact in Niger. Such risks were independent of the ABO blood type and positivity for the rhesus antigen. Pretransfusion diagnosis or posttransfusion therapy should be instituted to prevent it.
- Published
- 2019
26. Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria : a WorldWide Antimalarial Resistance Network individual participant data meta-analysis
- Author
-
Dahal, Prabin, Simpson, Julie Anne, Abdulla, Salim, Achan, Jane, Adam, Ishag, Agarwal, Aarti, Allan, Richard, Anvikar, Anupkumar R., Arinaitwe, Emmanuel, Ashley, Elizabeth A., Awab, Ghulam Rahim, Bassat, Quique, Bjorkman, Anders, Bompart, Francois, Borrmann, Steffen, Bousema, Teun, Broek, Ingrid, Bukirwa, Hasifa, Carrara, Verena I., Corsi, Marco, Cot, Michel, D'Alessandro, Umberto, Davis, Timothy M. E., de Wit, Marit, Deloron, Philippe, Desai, Meghna, Dimbu, Pedro Rafael, Djalle, Djibrine, Djimde, Abdoulaye, Dorsey, Grant, Doumbo, Ogobara K., Drakeley, Chris J., Duparc, Stephan, Edstein, Michael D., Espie, Emmanuelle, Faiz, Abul, Falade, Catherine, Fanello, Caterina, Faucher, Jean-Francois, Faye, Babacar, Fortes, Filomeno de Jesus, Gadalla, Nahla B., Gaye, Oumar, Gil, J. Pedro, Greenwood, Brian, Grivoyannis, Anastasia, Hamed, Kamal, Hien, Tran Tinh, Hughes, David, Humphreys, Georgina, Hwang, Jimee, Ibrahim, Maman Laminou, Janssens, Bart, Jullien, Vincent, Juma, Elizabeth, Kamugisha, Erasmus, Karema, Corine, Karunajeewa, Harin A., Kiechel, Jean R., Kironde, Fred, Kofoed, Poul-Erik, Kremsner, Peter G., Lameyre, Valerie, Lee, Sue J., Marsh, Kevin, Mårtensson, Andreas, Mayxay, Mayfong, Menan, Herve, Mens, Petra, Mutabingwa, Theonest K., Ndiaye, Jean-Louis, Ngasala, Billy E., Noedl, Harald, Nosten, Francois, Offianan, Andre Toure, Oguike, Mary, Ogutu, Bernhards R., Olliaro, Piero, Ouedraogo, Jean Bosco, Piola, Patrice, Plowe, Christopher V., Plucinski, Mateusz M., Pratt, Oliver James, Premji, Zulfikarali, Ramharter, Michael, Rogier, Christophe, Rombo, Lars, Rosenthal, Philip J., Sawa, Patrick, Schramm, Birgit, Sibley, Carol, Sinou, Veronique, Sirima, Sodiomon, Smithuis, Frank, Staedke, Sarah G., Sutanto, Inge, Talisuna, Ambrose Otau, Tarning, Joel, Taylor, Walter R. J., Temu, Emmanuel, Thriemer, Kamala L., Thuy, Nhien Nguyen, Udhayakumar, Venkatachalam, Ursing, Johan, van Herp, Michel, van Vugt, Michele, Whitty, Christopher, William, Yavo, Winnips, Cornelis, Zongo, Issaka, Guerin, Philippe, Price, Ric N., Stepniewska, Kasia, Dahal, Prabin, Simpson, Julie Anne, Abdulla, Salim, Achan, Jane, Adam, Ishag, Agarwal, Aarti, Allan, Richard, Anvikar, Anupkumar R., Arinaitwe, Emmanuel, Ashley, Elizabeth A., Awab, Ghulam Rahim, Bassat, Quique, Bjorkman, Anders, Bompart, Francois, Borrmann, Steffen, Bousema, Teun, Broek, Ingrid, Bukirwa, Hasifa, Carrara, Verena I., Corsi, Marco, Cot, Michel, D'Alessandro, Umberto, Davis, Timothy M. E., de Wit, Marit, Deloron, Philippe, Desai, Meghna, Dimbu, Pedro Rafael, Djalle, Djibrine, Djimde, Abdoulaye, Dorsey, Grant, Doumbo, Ogobara K., Drakeley, Chris J., Duparc, Stephan, Edstein, Michael D., Espie, Emmanuelle, Faiz, Abul, Falade, Catherine, Fanello, Caterina, Faucher, Jean-Francois, Faye, Babacar, Fortes, Filomeno de Jesus, Gadalla, Nahla B., Gaye, Oumar, Gil, J. Pedro, Greenwood, Brian, Grivoyannis, Anastasia, Hamed, Kamal, Hien, Tran Tinh, Hughes, David, Humphreys, Georgina, Hwang, Jimee, Ibrahim, Maman Laminou, Janssens, Bart, Jullien, Vincent, Juma, Elizabeth, Kamugisha, Erasmus, Karema, Corine, Karunajeewa, Harin A., Kiechel, Jean R., Kironde, Fred, Kofoed, Poul-Erik, Kremsner, Peter G., Lameyre, Valerie, Lee, Sue J., Marsh, Kevin, Mårtensson, Andreas, Mayxay, Mayfong, Menan, Herve, Mens, Petra, Mutabingwa, Theonest K., Ndiaye, Jean-Louis, Ngasala, Billy E., Noedl, Harald, Nosten, Francois, Offianan, Andre Toure, Oguike, Mary, Ogutu, Bernhards R., Olliaro, Piero, Ouedraogo, Jean Bosco, Piola, Patrice, Plowe, Christopher V., Plucinski, Mateusz M., Pratt, Oliver James, Premji, Zulfikarali, Ramharter, Michael, Rogier, Christophe, Rombo, Lars, Rosenthal, Philip J., Sawa, Patrick, Schramm, Birgit, Sibley, Carol, Sinou, Veronique, Sirima, Sodiomon, Smithuis, Frank, Staedke, Sarah G., Sutanto, Inge, Talisuna, Ambrose Otau, Tarning, Joel, Taylor, Walter R. J., Temu, Emmanuel, Thriemer, Kamala L., Thuy, Nhien Nguyen, Udhayakumar, Venkatachalam, Ursing, Johan, van Herp, Michel, van Vugt, Michele, Whitty, Christopher, William, Yavo, Winnips, Cornelis, Zongo, Issaka, Guerin, Philippe, Price, Ric N., and Stepniewska, Kasia
- Abstract
Background: Therapeutic efficacy studies in uncomplicated Plasmodium falciparum malaria are confounded by new infections, which constitute competing risk events since they can potentially preclude/pre-empt the detection of subsequent recrudescence of persistent, sub-microscopic primary infections. Methods: Antimalarial studies typically report the risk of recrudescence derived using the Kaplan-Meier (K-M) method, which considers new infections acquired during the follow-up period as censored. Cumulative Incidence Function (CIF) provides an alternative approach for handling new infections, which accounts for them as a competing risk event. The complement of the estimate derived using the K-M method (1 minus K-M), and the CIF were used to derive the risk of recrudescence at the end of the follow-up period using data from studies collated in the WorldWide Antimalarial Resistance Network data repository. Absolute differences in the failure estimates derived using these two methods were quantified. In comparative studies, the equality of two K-M curves was assessed using the log-rank test, and the equality of CIFs using Gray's k-sample test (both at 5% level of significance). Two different regression modelling strategies for recrudescence were considered: cause-specific Cox model and Fine and Gray's sub-distributional hazard model. Results: Data were available from 92 studies (233 treatment arms, 31,379 patients) conducted between 1996 and 2014. At the end of follow-up, the median absolute overestimation in the estimated risk of cumulative recrudescence by using 1 minus K-M approach was 0.04% (interquartile range (IQR): 0.00-0.27%, Range: 0.00-3.60%). The overestimation was correlated positively with the proportion of patients with recrudescence [Pearson's correlation coefficient (rho): 0.38, 95% Confidence Interval (CI) 0.30-0.46] or new infection [rho: 0.43; 95% CI 0.35-0.54]. In three study arms, the point estimates of failure were greater than 10% (the WHO threshold
- Published
- 2019
- Full Text
- View/download PDF
27. Molecular markers of resistance to amodiaquine plus sulfadoxine-pyrimethamine in an area with seasonal malaria chemoprevention in south central Niger
- Author
-
Ibrahim Maman Laminou, Alfred Amambua-Ngwa, Céline Langendorf, Lynda Woi-Messe, Umberto D'Alessandro, Carol Hopkins Sibley, Seidou H. Bouriema, Rebecca F. Grais, Thierry Fandeur, Rockyath Makarimi, and Philippe J Guerin
- Subjects
Male ,Veterinary medicine ,medicine.medical_treatment ,Drug Resistance ,Protozoan Proteins ,0302 clinical medicine ,030212 general & internal medicine ,Niger ,Malaria, Falciparum ,education.field_of_study ,biology ,Drug Combinations ,Infectious Diseases ,Pyrimethamine ,Child, Preschool ,Mass Drug Administration ,Female ,Seasons ,Multidrug Resistance-Associated Proteins ,medicine.drug ,lcsh:Arctic medicine. Tropical medicine ,Genotype ,lcsh:RC955-962 ,Sulfadoxine ,030231 tropical medicine ,Population ,Plasmodium falciparum ,Amodiaquine ,Chemoprevention ,lcsh:Infectious and parasitic diseases ,03 medical and health sciences ,Antimalarials ,parasitic diseases ,medicine ,Humans ,lcsh:RC109-216 ,education ,Dihydropteroate Synthase ,Research ,Prevention ,Infant ,Sequence Analysis, DNA ,medicine.disease ,biology.organism_classification ,Sulfadoxine/pyrimethamine ,Malaria ,Tetrahydrofolate Dehydrogenase ,Seasonal malaria chemoprophylaxis ,Parasitology ,Mutant Proteins - Abstract
Background In Niger, malaria transmission is markedly seasonal with most of the disease burden occurring in children during the rainy season. Seasonal malaria chemoprevention (SMC) with amodiaquine plus sulfadoxine– pyrimethamine (AQ + SP) is recommended in the country to be administered monthly just before and during the rainy season. Moreover, clinical decisions on use of SP for intermittent preventive treatment in pregnancy (IPTp) now depend upon the validated molecular markers for SP resistance in Plasmodium falciparum observed in the local parasite population. However, little is known about molecular markers of resistance for either SP or AQ in the south of Niger. To address this question, clinical samples which met clinical and biological criteria, were collected in Gabi, Madarounfa district, Maradi region, Niger in 2011–2012 (before SMC implementation). Molecular markers of resistance to pyrimethamine (pfdhfr), sulfadoxine (pfdhps) and amodiaquine (pfmdr1) were assessed by DNA sequencing. Results Prior to SMC implementation, the samples showed a high proportion of clinical samples that carried the pfdhfr 51I/59R/108N haplotype associated with resistance to pyrimethamine and pfdhps 436A/F/H and 437G mutations associated with reduced susceptibility to sulfadoxine. In contrast mutations in codons 581G, and 613S in the pfdhps gene, and in pfmdr1, 86Y, 184Y, 1042D and 1246Y associated with resistance to amodiaquine, were less frequently observed. Importantly, pfdhfr I164L and pfdhps K540E mutations shown to be the most clinically relevant markers for high level clinical resistance to SP were not detected in Gabi. Conclusion Although parasites with genotypes associated with the highest levels of resistance to AQ + SP are not yet common in this setting, their importance for deployment of SMC and IPTp dictates that monitoring of these markers of resistance should accompany these interventions. This study also highlights the parasite heterogeneity within a small spatial area and the need to use caution when extrapolating results from surveys of molecular markers of resistance in a single site to inform regional policy decisions.
- Published
- 2018
28. Efficacy of artesunate-amodiaquine, dihydroartemisinin-piperaquine and artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Maradi, Niger
- Author
-
Martin De Smet, Aliou Traore, Jean Rigal, Ibrahim Maman Laminou, Souleymane Dama, Odile Ouwe Missi Oukem-Boyer, Rockyath Makarimi, Francesco Grandesso, Ogobara K. Doumbo, Abdoulaye Djimde, Lynda Woi Messe, Ousmane Guindo, and Jean-François Etard
- Subjects
Male ,Artemether/lumefantrine ,Resistance ,Antimalarial ,Kaplan-Meier Estimate ,Parasite Load ,Efficacy ,0302 clinical medicine ,Dihydroartemisinin/piperaquine ,Global health ,030212 general & internal medicine ,Niger ,Artemisinin ,Malaria, Falciparum ,biology ,Artesunate/amodiaquine ,Artemisinins ,Drug Combinations ,Infectious Diseases ,Child, Preschool ,Quinolines ,Female ,medicine.drug ,medicine.medical_specialty ,lcsh:Arctic medicine. Tropical medicine ,lcsh:RC955-962 ,030231 tropical medicine ,lcsh:Infectious and parasitic diseases ,03 medical and health sciences ,Antimalarials ,Internal medicine ,parasitic diseases ,medicine ,Humans ,lcsh:RC109-216 ,Parasite clearance ,Lumefantrine ,business.industry ,Research ,Amodiaquine ,Infant ,Plasmodium falciparum ,biology.organism_classification ,medicine.disease ,Malaria ,Parasitology ,business - Abstract
Background Malaria endemic countries need to assess efficacy of anti-malarial treatments on a regular basis. Moreover, resistance to artemisinin that is established across mainland South-East Asia represents today a major threat to global health. Monitoring the efficacy of artemisinin-based combination therapies is of paramount importance to detect as early as possible the emergence of resistance in African countries that toll the highest burden of malaria morbidity and mortality. Methods A WHO standard protocol was used to assess efficacy of the combinations artesunate–amodiaquine (AS–AQ Winthrop®), dihydroartemisinin–piperaquine (DHA–PPQ, Eurartesim®) and artemether–lumefantrine (AM–LM, Coartem®) taken under supervision and respecting pharmaceutical recommendations. The study enrolled for each treatment arm 212 children aged 6–59 months living in Maradi (Niger) and suffering with uncomplicated falciparum malaria. The Kaplan–Meier 42-day PCR-adjusted cure rate was the primary outcome. A standardized parasite clearance estimator was used to assess delayed parasite clearance as surrogate maker of suspected artemisinin resistance. Results No early treatment failures were found in any of the study treatment arms. The day-42 PCR-adjusted cure rate estimates were 99.5, 98.4 and 99.0% in the AS–AQ, DHA–PPQ and AM–LM arms, respectively. The reinfection rate (expressed also as Kaplan–Meier estimates) was higher in the AM–LM arm (32.4%) than in the AS–AQ (13.8%) and the DHA–PPQ arm (24.9%). The parasite clearance rate constant was 0.27, 0.26 and 0.25 per hour for AS–AQ, DHA–PPQ and AM–LM, respectively. Conclusions All the three treatments evaluated largely meet WHO criteria (at least 95% efficacy). AS–AQ and AL–LM may continue to be used and DHA–PPQ may be also recommended as first-line treatment for uncomplicated falciparum malaria in Maradi. The parasite clearance rate were consistent with reference values indicating no suspected artemisinin resistance. Nevertheless, the monitoring of anti-malarial drug efficacy should continue. Trial registration details Registry number at ClinicalTrial.gov: NCT01755559
- Published
- 2017
29. Cours National de Paludologie du Niger : Bilan de cinq ans.
- Author
-
Ibrahim, Maman Laminou, primary, Labbo, Rabou, additional, Mahaman Moustapha, Lamine, additional, Arzika, Ibrahim, additional, Boubacar, Mahamadou, additional, Amadou, Soumana, additional, Izamne, Mahamadou, additional, Haladou, Sani, additional, Abdou Oumarou, Mamane, additional, Jakou, Hadiza, additional, Daou, Maman, additional, and Adehossi, Eric, additional
- Published
- 2017
- Full Text
- View/download PDF
30. Estimation de l’impact en santé publique de la chimioprévention du paludisme saisonnier au Niger
- Author
-
Salissou, Issa, primary, Mahaman Moustapha, Lamine, additional, Alkassoum, Ibrahim, additional, Hadiza, Djakou, additional, and Ibrahim, Maman Laminou, additional
- Published
- 2017
- Full Text
- View/download PDF
31. Perception de la chimioprévention du paludisme saisonnier au Niger
- Author
-
Salissou, Issa, primary, Mahaman Moustapha, Lamine, additional, Yerima, Bako, additional, Alkassoum, Ibrahim, additional, Hadiza, Djakou, additional, and Ibrahim, Maman Laminou, additional
- Published
- 2017
- Full Text
- View/download PDF
32. Low Prevalence of Pfcrt Resistance Alleles among Patients with Uncomplicated Falciparum Malaria in Niger Six Years after Chloroquine Withdrawal
- Author
-
Salissou, Adamou, primary, Zamanka, Halima, additional, Biyghe Binze, Brigitte, additional, Rivière, Taiana, additional, Tichit, Magalie, additional, Ibrahim, Maman Laminou, additional, and Fandeur, Thierry, additional
- Published
- 2014
- Full Text
- View/download PDF
33. Field-based evidence of fast and global increase of Plasmodium falciparum drug-resistance by DNA-microarrays and PCR/RFLP in Niger
- Author
-
Ibrahim, Maman Laminou, primary, Steenkeste, Nicolas, additional, Khim, Nimol, additional, Adam, Hadiza Hassane, additional, Konaté, Lassana, additional, Coppée, Jean-Yves, additional, Ariey, Fredéric, additional, and Duchemin, Jean-Bernard, additional
- Published
- 2009
- Full Text
- View/download PDF
34. Polymorphism of PfATPase in Niger: detection of three new point mutations
- Author
-
Ibrahim, Maman Laminou, primary, Khim, Nimol, additional, Adam, Hassane Hadiza, additional, Ariey, Frédéric, additional, and Duchemin, Jean-Bernard, additional
- Published
- 2009
- Full Text
- View/download PDF
35. Controlling Schistosomiasis: Significant Decrease of Anaemia Prevalence One Year after a Single Dose of Praziquantel in Nigerien Schoolchildren
- Author
-
Tohon, Zilahatou B., primary, Mainassara, Halima B., additional, Garba, Amadou, additional, Mahamane, Ali E., additional, Bosqué-Oliva, Elisa, additional, Ibrahim, Maman-Laminou, additional, Duchemin, Jean-Bernard, additional, Chanteau, Suzanne, additional, and Boisier, Pascal, additional
- Published
- 2008
- Full Text
- View/download PDF
36. Field-based evidence for the linkage of pfcrt and pfdhfr drug-resistant malaria genotypes and clinical profiles of severe malaria in Niger
- Author
-
Ibrahim, Maman Laminou, primary, Gay-Andrieu, Françoise, additional, Adehossi, Eric, additional, Lacroix, Veronique, additional, Randrianarivelojosia, Milijaona, additional, and Duchemin, Jean-Bernard, additional
- Published
- 2007
- Full Text
- View/download PDF
37. Epidemiological, clinical and biological features of malaria among children in Niamey, Niger.
- Author
-
Gay-Andrieu, Françoise, Adehossi, Eric, Lacroix, Véronique, Gagara, Moussa, Ibrahim, Maman Laminou, Kourna, Hama, and Boureima, Hamadou
- Subjects
MALARIA diagnosis ,JUVENILE diseases ,HEALTH surveys ,EPIDEMIOLOGY ,ANTHROPOMETRY - Abstract
Background: Malaria takes a heavy toll in Niger, one of the world's poorest countries. Previous evaluations conducted in the context of the strategy for the Integrated Management of Childhood Illness, showed that 84% of severe malaria cases and 64 % of ordinary cases are not correctly managed. The aim of this survey was to describe epidemiological, clinical and biological features of malaria among <5 year-old children in the paediatric department of the National Hospital of Niamey, Niger's main referral hospital. Methods: The study was performed in 2003 during the rainy season from July 25
th to October 25th . Microscopic diagnosis of malaria, complete blood cell counts and measurement of glycaemia were performed in compliance with the routine procedure of the laboratory. Epidemiological data was collected through interviews with mothers. Results: 256 children aged 3-60 months were included in the study. Anthropometrics and epidemiological data were typical of a very underprivileged population: 58% of the children were suffering from malnutrition and all were from poor families. Diagnosis of malaria was confirmed by microscopy in 52% of the cases. Clinical symptoms upon admission were non-specific, but there was a significant combination between a positive thick blood smear and neurological symptoms, and between a positive thick blood smear and splenomegaly. Thrombopaenia was also statistically more frequent among confirmed cases of malaria. The prevalence of severe malaria was 86%, including cases of severe anaemia among < 2 year-old children and neurological forms after 2 years of age. Overall mortality was 20% among confirmed cases and 21% among severe cases. Conclusions: The study confirmed that malaria was a major burden for the National Hospital of Niamey. Children hospitalized for malaria had an underprivileged background. Two distinctive features were the prevalence of severe malaria and a high mortality rate. Medical and non-medical underlying factors which may explain such a situation are discussed. [ABSTRACT FROM AUTHOR]- Published
- 2005
- Full Text
- View/download PDF
38. Factors associated with COVID-19 in children aged 0 to 15 in Niger, 2020.
- Author
-
Amadou, Habibatou Idé, Yoda, Herman, Tialla, Dieudonné, Yanogo, Pauline Kiswendsida, Barry, Djibril, Ibrahim, Maman Laminou, Aboubacar, Samaila, Youssoufou Souley, Abdoul Salam, Ousmane, Abdoulaye, and Meda, Nicolas
- Subjects
- *
YOUNG adults , *ABANDONED children , *COVID-19 pandemic , *AGE groups , *DATABASES - Abstract
On January 30, 2020, the WHO declared COVID-19 a global health emergency. Children were affected in less severe forms. Niger had implemented measures in a context where children were a source of contamination. The aim was to determine the factors associated with COVID-19 in children in Niger from February to August 2020 through an analysis of the national database. We conducted an analytical cross-sectional study including all COVID-19 suspects in the database. We used Excel and Epi Info 7.2.4. software for data extraction and analysis. Frequencies and proportions were calculated, and in a logistic regression, we estimated the ORs of association with their 95% confidence intervals, the factors associated with COVID-19 at the threshold of p<0.05. Of 572 notified cases of suspected COVID-19 in children aged 0-15, 11.36% were positive. The median age of infected children was 10 years [IQR: 5-13 years]. The male/female sex ratio was 2.1. Children aged 11 to 15 accounted for 49.2%, 61.5% lived in Niamey, 4.6% had comorbidities. The notion of travel was 12.3% and 40% had a notion of contact, 24.4% had a fever, 23.2% had a cough, 18% were hospitalized, and a case-fatality rate of 1.5%. In etiological analysis, the factors associated with COVID-19 were sex ORa=0.51 [0.28-0.93] p=0.028, presence of symptoms ORa=2.29 [1.23-4.25] p=0.008 and notion of contact ORa=0.32 [0.13-0.77] p=0.011. Exposed children were sensitive to COVID-19, and all age groups were affected, with a predominance of males. We recommend barrier measures adapted to young people, and early detection and management of infected children. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
39. [First detection of Rift Valley Fever Virus among Culex pipiens in Tahoua, Niger].
- Author
-
Mahamane Iro S, Lagare A, Maiga AA, Nouhou Z, Gagara H, Ousmane H, Hassoumi Sanda AN, Zamanka H, Amadou S, Boubakar F, Issa Arzika I, and Ibrahim Maman L
- Subjects
- Animals, Cross-Sectional Studies, Niger epidemiology, Mosquito Vectors virology, Humans, Insect Vectors virology, Rift Valley fever virus isolation & purification, Rift Valley fever virus genetics, Culex virology, Rift Valley Fever epidemiology, Rift Valley Fever transmission, Rift Valley Fever virology
- Abstract
Background: The Rift Valley Fever (RVF) is an arbovirus disease responsible of regular epizootics and epidemics in sub-Saharan Africa and Arabian Peninsula. In 2016, Niger experienced its first outbreak of RVF in Tahoua region, which resulted in high consequences in animal and human health. The aim of this study was to investigate on the RVFV circulation among potential vectors of the disease., Methods: This was a cross-sectional survey carried out in Tahoua and Agadez regions in August 2021. Adult mosquitoes were collected by using the morning spray in human dwellings and the CDC light trap methods. After morphological identification, viral RNA was extracted. The RNA was extracted by using QIAamp Viral RNA Mini Kit (Qiagen). The RVFV detection was performed by using the qRT-PCR method., Results: A total of 2487 insects (1978 mosquitoes, 509 sandflies and 251 biting midges) were identified and divided into three families (Culicidae, Psychodidae and Ceratopogonidae). The Culicidae family composed of the Culex genus being the most abundant with a predominance of Cx.pipiens (31.88%; n = 793) followed by Mansonia sp (21.51%; n = 535), Anophelesgambiae s.l. (8.44%; n = 210), An. pharoensis (0.72%; n = 18), An. rufipes (0.48%; n = 12), Cx. quinquefasciatus (6.39%; n = 159), the Psychodidae with sandflies (20.46%; n = 509), and the Ceratopogonidae with Culicoides genus (10.09%; n = 251). The qRT-PCR carried out on a sample of mosquitoes (N = 96) highlighted that one individual of Cx.pipiens was found positive to RVFV. This specimen was from Tassara locality (Tahoua) and collected by CDC Light Trap method., Conclusion: This study reveals for the first time the circulation of RVFV among Cx.pipiens in Niger and highlights the possible vectorial role of this vector in the disease transmission. Further investigations should be carried out to identify the biological and ecological determinants that support the maintenance of the virus in this area in order to guide control interventions., Competing Interests: Les auteurs déclarent ne pas avoir de conflit d’intérêts., (Copyright © 2024 SFMTSI.)
- Published
- 2024
- Full Text
- View/download PDF
40. [Comparison of the therapeutic efficiency and of the tolerance of the artemether-lumefantrine and artesunate-amodiaquine combination in Niger].
- Author
-
Ibrahim ML, Sadou F, Daou M, Halima BM, Abani M, Halima Z, Ibrahim A, Mahamadou B, and Eric A
- Abstract
Malaria is a major public health problem in Niger. The Global Fund to fight AIDS, Tuberculosis, and Malaria launched, in 2011, an initiative entitled "Affordable Medicines Facility - Malaria" or AMFm which aims to make artemisinin-based combination therapies (ACT) more available, more accessible and to eliminate the development of artemisinin resistance. It is in this context that we have conducted a randomized comparative double open-arm study of the efficacy and safety of artemether-lumefantrine (AL) and artesunate-amodiaquine (AM) in Gaya., The objective of the study is to evaluate and then to compare the efficiency and tolerance to these two combinations. The study was modeled with the WHO 2003, 28 days protocol., 370 febrile patients were examined. 159 patients were included, where 79 (49.4%) were put in the AL arm and 81 (50.6%) were placed in the AM arm. The adequate clinical and parasitological response was 94.8% and 97.1% respectively for AL and AM. There was no statistical significant difference in efficiency between the two therapies (P=0.4) . This difference in adverse effects was not statistically significant (P=0.18) . Artemether-lumefantrine and artesunate-amodiaquine are two combinations with comparable efficacies and safety., (Le comitée de rédaction se réserve le droit de revoyer aux auteurs avant toute soumission à l'avis des lecteurs les manuscrits qui ne seraient pas conformes à ces modalités de présentation. En outre il leur conseille de sonserver un examplaire du manuscrit, des figures et des tableaux.)
- Published
- 2016
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.