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Objective: Inflammation and pain are normally present concomitantly, which requires using a combination of anti-inflammatory and pain killer medications. This could potentially decrease patient adherence to such combinations. Therefore, there is an urgent need to develop combinations of antiinflammatory and analgesic therapies. This study is designed to evaluate the analgesic and antiinflammatory activities of a newly synthetic compound of ibuprofen and gabapentin. Method: The study protocol includes two stages. The first stage: the evaluation of the analgesic effectiveness of tested compounds via using hot plate and acetic acid induced-writhing tests. The second stage: the investigation of the anti-inflammatory activity via using dextran induced-peritonitis, cotton pelt induced-granulomas, and formalin induced-paw edema analyses. Rats were randomly divided into four groups (six rats in each group): Group A (control): rats were orally treated with vehicle (propylene glycol 50 % v/v); Group B: rats were orally treated with ibuprofen (10 mg/kg); Group C: rats were orally treated with gabapentin (200 mg/kg); and Group D: rats were orally treated with the synthetic compound (ibuprofen-gabapentin) in dose equivalent to 10 mg/kg ibuprofen and 200 mg/kg gabapentin. Result: It was found that the newly synthesized compound of ibuprofen and gabapentin has significantly reduced the pain in comparison with control groups. Additionally, this compound has significant anti-inflammatory properties compared to medications admitted to the control group as well. Conclusion: The newly synthesized compound (ibuprofen-gabapentin) demonstrates remarkable analgesic and anti-inflammatory activities in comparison with the conventional compounds. [ABSTRACT FROM AUTHOR]

Objective: Inflammation and pain are normally present concomitantly, which requires using a combination of anti-inflammatory and pain killer medications. This could potentially decrease patient adherence to such combinations. Therefore, there is an urgent need to develop combinations of anti-inflammatory and analgesic therapies. This study is designed to evaluate the analgesic and anti-inflammatory activities of a newly synthetic compound of ibuprofen and gabapentin. Method: The study protocol includes two stages. The first stage: the evaluation of the analgesic effectiveness of tested compounds via using hot plate and acetic acid induced-writhing tests. The second stage: the investigation of the anti-inflammatory activity via using dextran induced- peritonitis, cotton pelt induced- granulomas, and formalin induced- paw edema analyses. Rats were randomly divided into four groups (six rats in each group): Group A (control): rats were orally treated with vehicle (propylene glycol 50 % v/v); Group B: rats were orally treated with ibuprofen (10 mg/ kg); Group C: rats were orally treated with gabapentin (200 mg/ kg); and Group D: rats were orally treated with the synthetic compound (ibuprofen-gabapentin) in dose equivalent to 10 mg/ kg ibuprofen and 200 mg/kg gabapentin. Result: It was found that the newly synthesized compound of ibuprofen and gabapentin has significantly reduced the pain in comparison with control groups. Additionally, this compound has significant anti-inflammatory properties compared to medications admitted to the control group as well. Conclusion: The newly synthesized compound (ibuprofen-gabapentin) demonstrates remarkable analgesic and anti-inflammatory activities in comparison with the conventional compounds. [ABSTRACT FROM AUTHOR]

Objective: Environmental pollution with heavy metals has become a matter of concern, lead is one of those metals, Lead is a cumulative, multi-systemic toxicant which affects major body systems; it is associated with number of changes that include impairment of liver function. This work was designed to investigate the protective effect of vinpocetine on hepatotoxicity induced by lead acetate in rats. Method: Eighteen adult rats of both sexes were used in this study; the animals were randomly enrolled into three groups of 6 rats each: Group I- Each rat was orally inoculated with 0.3 ml saline. Intraperitoneal (i.p.) injection of 100 μl of saline was given 1 h later, this group served as control. Group II- rats daily received an intraperitoneal injection of freshly prepared lead acetate (20 mg/kg body wt.) for 5 days. Group III- Rats in this group received vinpocetine and lead as the following; at first vinpocetine administered orally in a dose of 3mg/kg/day (dissolved in normal saline) for 5 days alone and then lead injection started in a dose of 20 mg/kg and continued for 10 days with oral vinpocetine dose where vinpocetine administered 1hr before lead. 24 hours after the last dose, the liver of each animal was excised to prepare homogenate for estimation interleukin-1 beta (IL-1β), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-α) and caspase 3. Result: Lead significantly (P < 0.05) elevated IL-1beta, TNF-α and caspase 3, while it significantly (P < 0.05) reduced IL-10 levels. On the other hand, vinpocetine significantly (P < 0.05) decreased IL-1beta and caspase 3 but it doesn’t significantly (P > 0.05) reduce TNF-α and it significantly (P < 0.05) increase IL-10. Conclusion: vinpocetine may have a protective effect against lead-induced hepatotoxicity in rats. [ABSTRACT FROM AUTHOR]