Search

Khalid Altigani Ahmed,1 Alnada Ibrahim,2 Daniel Gonzalez,3 Abubakr O Nur4 1Department of Clinical Pharmacy, College of Pharmacy, Najran University, Najran, Saudi Arabia; 2Department of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia; 3Division of Clinical Pharmacology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA; 4Department of Pharmaceutics, Faculty of Pharmacy, University of Khartoum, Khartoum, SudanCorrespondence: Alnada Ibrahim, Department of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia, Email alaibrahim@pnu.edu.saPurpose: The study aimed to perform a population pharmacokinetic (PK) analysis to obtain vancomycin PK parameter estimates in Sudanese adult patients. The population PK model is then applied to perform model-based dose optimization.Patients and Methods: Data were collected through a retrospective, single-center, observational cohort study performed in Aliaa Specialist Hospital, Khartoum, Sudan. A population PK model was developed using the MonolixSuite 2020R1 to explore the potential effects of demographics and laboratory covariates on vancomycin PK. Monte Carlo simulations were performed to optimize dosage regimens as a function of creatinine clearance (CLcr) and virtual patients were partitioned into five CLcr groups.Results: We retrospectively collected 194 vancomycin plasma concentrations from 99 adults. The median (interquartile range) for age (years) and CLcr (mL/min) were 65 (50– 75) and 12.7 (5.52– 25.78), respectively. Vancomycin PK data were best fitted using a one-compartment model with linear elimination. The estimates of clearance and volume of distribution were 2.02 L/h and 65 L, respectively. CLcr was identified as the main covariate explaining the PK variability in vancomycin CL. CL significantly decreased with decreasing CLcr. For the five CLcr groups evaluated

Mansour A Mahmoud,1 Alnada Ibrahim,2 Fawaz Alharbi,3 Ali Mohammed Alalawi,4 Faris Alnezary,1 Ahmed Aldafiri,3 Yaser Alahmadi,1 Sultan Othman Alolayan,1 Sultan S Althaqfan,1 Mohammed M Alsultan,5 Safaa Omer,6 Musaad B Alsahly7 1Department of Clinical and Hospital Pharmacy, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Saudi Arabia; 2Department of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O.Box 84428, Riyadh, 11671, Saudi Arabia; 3AlHaram Hospital, Ministry of Health, Al-Madinah Al-Munawarah, Saudi Arabia; 4Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Saudi Arabia; 5Department of Pharmacy Practice, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 6Department of Clinical Biochemistry, College of Medicine, King Khalid University, Abha, Saudi Arabia; 7College of Medicine, Department of Physiology, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Alnada Ibrahim, Department of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia, Email alaibrahim@pnu.edu.sa Mansour A Mahmoud, Department of Clinical and Hospital Pharmacy, College of Pharmacy, Taibah University, AL-Madinah Al-Munawara, Saudi Arabia, Email mammm.99@gmail.comObjective: To investigate public uptake, attitudes and the safety of the first and second doses of COVID-19 vaccination.Methods: This was a cross-sectional web-based survey study. A self-administered questionnaire was prepared from a literature search and information about COVID-19 available at various resources. The developed questionnaire was validated for readability by experts and refined in light of the feedback received from the experts and the final version was prepared. The reliability of the questionnaire was 0.7 which shows an acceptable level of scale internal consistency. The data analysis was

Najla Altwaijry,1 Alnada Ibrahim,2,3 Reem Binsuwaidan,1 Lina I Alnajjar,2 Bshra A Alsfouk,1 Raghdah Almutairi4 1Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia; 2Department of Pharmacy Practice, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia; 3Department of Pharmaceutics, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan; 4College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi ArabiaCorrespondence: Alnada IbrahimDepartment of Pharmacy Practice, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi ArabiaTel +966503308360Email alnada44@hotmail.comPurpose: This study aimed at describing the experience of academic staff and students with distance education, during the COVID-19 pandemic, at a college of pharmacy in Saudi Arabia.Methods: This study used a mixed-method approach. The first phase implemented a survey that targeted both academic staff and students to evaluate their experiences with distance education during the COVID-19 pandemic. Then, a focus group discussion was conducted to explore, in-depth, their experience. The survey consisted of five domains as follows: readiness for the shift to distance education during the full and partial lockdown, perception towards distance education, barriers against distance education, and the acquisitions due to distance education. A five-point Likert scale was used to assess participants’ responses to the different domains (mean score ± standard deviation).Results: Seventy-eight percent of the academic staff and 65% of the students responded to the survey. Participants’ views were positive for readiness for the shift to distance education during the full lockdown (3.89± 0.42 for academic staff and 3.82± 0.50 for students) with almost similar evaluation for the readiness during the blended learni