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376 results on '"Ibarretxe‐Bilbao, Naroa"'

2. Enhancing Creativity with Combined Transcranial Direct Current and Random Noise Stimulation of the Left Dorsolateral Prefrontal Cortex and Inferior Frontal Gyrus

Author

Peña, Javier, Muthalib, Makii, Sampedro, Agurne, Cardoso-Botelho, Mafalda, Zabala, Oihana, Ibarretxe-Bilbao, Naroa, García-Guerrero, Acebo, Zubiaurre-Elorza, Leire, and Ojeda, Natalia

Abstract

Creativity is a fundamental human accomplishment from scientific advances to composing music. The left dorsolateral prefrontal cortex (DLPFC) and inferior frontal gyrus (IFG) are important metacontrol hubs in flexibility and persistence brain states, respectively. Those hubs are related to divergent thinking, insight problem-solving, and convergent thinking. In this double-blind, between-subjects study, 81 healthy participants were randomly assigned to one of three groups (n = 27) that received a combined transcranial direct current stimulation-transcranial random noise stimulation (tDCS-tRNS) protocol with the anode over the left DLPFC and cathode over the left IFG (+DLPFC-IFG), the opposite montage (-DLPFC+IFG), and a sham group (+DLPFC-IFG). Both active tDCS-tRNS groups received 20 min of 1 mA tDCS with 1 mA (100-500 Hz) tRNS. Creativity was assessed before (baseline) and during stimulation with the Unusual Uses, Picture Completion (PC), Remote Association test (RAT), Matchstick Arithmetic (MA), and Nine-dot (ND) problems. Only the +DLPFC-IFG group had significantly higher scores compared with sham in the RAT (p = 0.009), PC fluency (p = 0.018), PC originality (p = 0.007), ND (p = 0.007), and MA (p = 0.032). Overall, -DLPFC+IFG had greater scores in all creativity tests compared with sham. Implications from the metacontrol theory are discussed.

Published
2023
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7. The Effect of Changing the Balance between Right and Left Dorsolateral Prefrontal Cortex on Different Creativity Tasks: A Transcranial Random Noise Stimulation Study

Author

Peña, Javier, Sampedro, Agurne, Gómez-Gastiasoro, Ainara, Ibarretxe-Bilbao, Naroa, Zubiaurre-Elorza, Leire, Aguiar, Covadonga, and Ojeda, Natalia

Abstract

Transcranial random noise stimulation (tRNS) increases performance in some perceptual tasks. However, little is known about its effect on creativity. Although dorsolateral prefrontal cortex (DLPFC) has been postulated as an important cortical area related to creativity, the relative role of left and right DLPFC is still unclear. We aimed to compare the effect of anodal left/cathodal right (L + R-) and cathodal left/anodal right (L - R+) tRNS over the DLPFC. Eighty-four participants were randomly assigned to L + R-, L-R+ or sham group. Current was set at 2 mA (100-500 Hz) with a 1 mA direct current offset (20 min). Creativity was assessed before and during tRNS with the Remotes Associates Test (RAT), Unusual Uses (UU) and Picture Completion (PC) from Torrance Test of Creative Thinking, nine-dot problem and matchstick arithmetic problems. Bootstrapped analysis of covariance (under-stimulation scores controlling for baseline) showed that L + R- and L - R+ groups had higher scores than sham in UU whereas only L + R- improved in RAT compared to sham. The L - R+ group performed significantly better than L + R- and sham groups in PC, nine-dot problem and matchstick arithmetic problems. L + R- DLPFC may help verbal creative thinking whereas the L - R + seems to produce a "releasing effect" through insight problem solving and originality.

Published
2021
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14. Parkinson’s Disease

Author

Díez-Cirarda, María, Ibarretxe-Bilbao, Naroa, Peña, Javier, Ojeda, Natalia, DeLuca, John, editor, Chiaravalloti, Nancy D., editor, and Weber, Erica, editor

Published
2020
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25. Schizophrenia

Author

Del Pozo, Natalia Ojeda, Lasa, Javier Peña, Ibarretxe-Bilbao, Naroa, Kreutzer, Jeffrey S., editor, DeLuca, John, editor, and Caplan, Bruce, editor

Published
2018
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26. Parkinson’s Disease

Author

Díez-Cirarda, María, Ibarretxe-Bilbao, Naroa, Baron, Mark S., Peña, Javier, Ojeda, Natalia, Kreutzer, Jeffrey S., editor, DeLuca, John, editor, and Caplan, Bruce, editor

Published
2018
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33. Analyzing structural and functional brain changes related to an integrative cognitive remediation program for schizophrenia: A randomized controlled trial

Author

Educación física y deportiva, Procesos psicológicos básicos y su desarrollo, Gorputz eta Kirol Hezkuntza, Oinarrizko psikologia prozesuak eta haien garapena, Sampedro, Agurne, Ibarretxe Bilbao, Naroa, Peña Lasa, Javier, Cabrera Zubizarreta, Alberto, Sánchez Gómez, Pedro María, Gómez Gastiasoro, Ainara, Iriarte Yoller, Nagore, Pavón, Cristóbal, Tous Espelosin, Mikel, Ojeda, Natalia, Educación física y deportiva, Procesos psicológicos básicos y su desarrollo, Gorputz eta Kirol Hezkuntza, Oinarrizko psikologia prozesuak eta haien garapena, Sampedro, Agurne, Ibarretxe Bilbao, Naroa, Peña Lasa, Javier, Cabrera Zubizarreta, Alberto, Sánchez Gómez, Pedro María, Gómez Gastiasoro, Ainara, Iriarte Yoller, Nagore, Pavón, Cristóbal, Tous Espelosin, Mikel, and Ojeda, Natalia

Abstract

Cognitive remediation has been shown to improve cognition in schizophrenia, but little is known about the specific functional and structural brain changes related to the implementation of an integrative cognitive remediation program. This study analyzed the functional and structural brain changes identified after implementing an integrative cognitive remediation program, REHACOP, in schizophrenia. The program combined cognitive remediation, social cognitive training, and functional and social skills training. The sample included 59 patients that were assigned to either the REHACOP group or an active control group for 20 weeks. In addition to a clinical and neuropsychological assessment, T1-weighted, diffusion-weighted and functional magnetic resonance images were acquired during a resting-state and during a memory paradigm, both at baseline and follow-up. Voxel-based morphometry, tract-based spatial statistics, resting-state functional connectivity, and brain activation analyses during the memory paradigm were performed. Brain changes were assessed with a 2 × 2 repeated-measure analysis of covariance for group x time interaction. Intragroup paired t-tests were also carried out. Repeated-measure analyses revealed improvements in cognition and functional outcome, but no significant brain changes associated with the integrative cognitive remediation program. Intragroup analyses showed greater gray matter volume and cortical thickness in right temporal regions at post-treatment in the REHACOP group. The absence of significant brain-level results associated with cognitive remediation may be partly due to the small sample size, which limited the statistical power of the study. Therefore, further research is needed to clarify whether the temporal lobe may be a key area involved in cognitive improvements following cognitive remediation.

Published
2023

34. Enhancement of Divergent Creative Thinking After Transcranial Near-Infrared Photobiomodulation Over the Default Mode Network.

Author

Peña, Javier, Muthalib, Makii, Beaty, Roger E., Sampedro, Agurne, Ibarretxe-Bilbao, Naroa, Zubiaurre-Elorza, Leire, García-Guerrero, M. Acebo, Cortazar, Ibon, Niso, Mikel, and Ojeda, Natalia

Subjects
DEFAULT mode network, DIVERGENT thinking, CREATIVE thinking, PHOTOBIOMODULATION therapy, TRANSCRANIAL direct current stimulation, NEAR infrared radiation, TREATMENT effectiveness
Abstract

Transcranial photobiomodulation (tPBM) has been used for cognitive enhancement in healthy people. However, its effect on creativity has not been investigated. The default mode network (DMN) is associated with divergent thinking (DT; but not convergent thinking, CT), and also with anxiety, which in turn has been negatively related to creativity. We aimed to use tPBM over the DMN to assess the effect on DT compared to sham. Additionally, we assessed the possible mediating effect of anxiety between tPBM and DT. In this single-blind, between-subjects study, 58 healthy participants were randomly assigned to tPBM or sham group. tPBM was applied using near-infrared light (810 nm, 40 Hz; 50% duty cycle), through light-emitting diode devices combining transcranial plus intranasal PBM over the cortical nodes of the DMN for 20 min (240 J/cm2 in total). DT and CT were assessed before (baseline) and after tPBM with the Unusual Uses (UU), Picture Completion (PC) and Remote Associates test (RAT). ANCOVA (post-stimulation controlling for baseline) results showed that tPBM group had significantly higher scores compared to sham in total UU, PC, and total DT. tPBM may be effective for DT enhancement. The lack of effect on CT reveals a specific link between DMN and DT. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Brain Degeneration in Synucleinopathies Based on Analysis of Cognition and Other Nonmotor Features: A Multimodal Imaging Study

Author

Lucas-Jiménez, Olaia, primary, Ibarretxe-Bilbao, Naroa, additional, Diez, Ibai, additional, Peña, Javier, additional, Tijero, Beatriz, additional, Galdós, Marta, additional, Murueta-Goyena, Ane, additional, Del Pino, Rocío, additional, Acera, Marian, additional, Gómez-Esteban, Juan Carlos, additional, Gabilondo, Iñigo, additional, and Ojeda, Natalia, additional

Published
2023
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36. Preterm Birth and Early Life Environmental Factors: Neuropsychological Profiles at Adolescence and Young Adulthood

Author

de Gamarra, Lexuri Fernández, primary, Zubiaurre-Elorza, Leire, additional, Gómez-Gastiasoro, Ainara, additional, Molins-Sauri, Marta, additional, Loureiro, Begoña, additional, Peña, Javier, additional, García-Guerrero, María Acebo, additional, Ibarretxe-Bilbao, Naroa, additional, Bruna, Olga, additional, Junqué, Carme, additional, Macaya, Alfons, additional, Poca, Maria A., additional, and Ojeda, Natalia, additional

Published
2023
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38. Correction to: Multimodal visual system analysis as a biomarker of visual hallucinations in Parkinson’s disease

Author

Diez-Cirarda, Maria, primary, Cabrera-Zubizarreta, Alberto, additional, Murueta-Goyena, Ane, additional, Strafella, Antonio P., additional, Del Pino, Rocio, additional, Acera, Marian, additional, Lucas-Jiménez, Olaia, additional, Ibarretxe-Bilbao, Naroa, additional, Tijero, Beatriz, additional, Gómez-Esteban, Juan Carlos, additional, and Gabilondo, Iñigo, additional

Published
2022
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39. Parkinson’s Disease

Author

Díez-Cirarda, María, primary, Ibarretxe-Bilbao, Naroa, additional, Peña, Javier, additional, and Ojeda, Natalia, additional

Published
2017
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41. Multimodal visual system analysis as a biomarker of visual hallucinations in Parkinson’s disease

Author

Diez-Cirarda, Maria, primary, Cabrera-Zubizarreta, Alberto, additional, Murueta-Goyena, Ane, additional, Strafella, Antonio P., additional, Del Pino, Rocio, additional, Acera, Marian, additional, Lucas-Jiménez, Olaia, additional, Ibarretxe-Bilbao, Naroa, additional, Tijero, Beatriz, additional, Gómez-Esteban, Juan Carlos, additional, and Gabilondo, Iñigo, additional

Published
2022
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42. Comparing transcranial direct current stimulation and transcranial random noise stimulation over left dorsolateral prefrontal cortex and left inferior frontal gyrus: Effects on divergent and convergent thinking

Author

Peña, Javier, primary, Sampedro, Agurne, additional, Balboa-Bandeira, Yolanda, additional, Ibarretxe-Bilbao, Naroa, additional, Zubiaurre-Elorza, Leire, additional, García-Guerrero, M. Acebo, additional, and Ojeda, Natalia, additional

Published
2022
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45. Schizophrenia

Author

Del Pozo, Natalia Ojeda, primary, Lasa, Javier Peña, additional, and Ibarretxe-Bilbao, Naroa, additional

Published
2017
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47. Enhancing Creativity With Combined Transcranial Direct Current and Random Noise Stimulation of the Left Dorsolateral Prefrontal Cortex and Inferior Frontal Gyrus

Author

Peña, Javier, primary, Muthalib, Makii, additional, Sampedro, Agurne, additional, Cardoso‐Botelho, Mafalda, additional, Zabala, Oihana, additional, Ibarretxe‐Bilbao, Naroa, additional, García‐Guerrero, Acebo, additional, Zubiaurre‐Elorza, Leire, additional, and Ojeda, Natalia, additional

Published
2022
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48. Cover Image

Author

C. Monte‐Rubio, Gemma, primary, Segura, Barbara, additional, P. Strafella, Antonio, additional, van Eimeren, Thilo, additional, Ibarretxe‐Bilbao, Naroa, additional, Diez‐Cirarda, Maria, additional, Eggers, Carsten, additional, Lucas‐Jiménez, Olaia, additional, Ojeda, Natalia, additional, Peña, Javier, additional, Ruppert, Marina C., additional, Sala‐Llonch, Roser, additional, Theis, Hendrik, additional, Uribe, Carme, additional, and Junque, Carme, additional

Published
2022
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49. Parameters from site classification to harmonize MRI clinical studies: Application to a multi-site Parkinson's disease dataset

Author

Monte-Rubio, Gemma C., Segura, Barbara, Strafella, Antonio P., van Eimeren, Thilo, Ibarretxe-Bilbao, Naroa, Diez-Cirarda, Maria, Eggers, Carsten, Lucas-Jimenez, Olaia, Ojeda, Natalia, Pena, Javier, Ruppert, Marina C., Sala-Llonch, Roser, Theis, Hendrik, Uribe, Carme, Junque, Carme, Monte-Rubio, Gemma C., Segura, Barbara, Strafella, Antonio P., van Eimeren, Thilo, Ibarretxe-Bilbao, Naroa, Diez-Cirarda, Maria, Eggers, Carsten, Lucas-Jimenez, Olaia, Ojeda, Natalia, Pena, Javier, Ruppert, Marina C., Sala-Llonch, Roser, Theis, Hendrik, Uribe, Carme, and Junque, Carme

Abstract

Multi-site MRI datasets are crucial for big data research. However, neuroimaging studies must face the batch effect. Here, we propose an approach that uses the predictive probabilities provided by Gaussian processes (GPs) to harmonize clinical-based studies. A multi-site dataset of 216 Parkinson's disease (PD) patients and 87 healthy subjects (HS) was used. We performed a site GP classification using MRI data. The outcomes estimated from this classification, redefined like Weighted HARMonization PArameters (WHARMPA), were used as regressors in two different clinical studies: A PD versus HS machine learning classification using GP, and a VBM comparison (FWE-p < .05, k = 100). Same studies were also conducted using conventional Boolean site covariates, and without information about site belonging. The results from site GP classification provided high scores, balanced accuracy (BAC) was 98.39% for grey matter images. PD versus HS classification performed better when the WHARMPA were used to harmonize (BAC = 78.60%; AUC = 0.90) than when using the Boolean site information (BAC = 56.31%; AUC = 0.71) and without it (BAC = 57.22%; AUC = 0.73). The VBM analysis harmonized using WHARMPA provided larger and more statistically robust clusters in regions previously reported in PD than when the Boolean site covariates or no corrections were added to the model. In conclusion, WHARMPA might encode global site-effects quantitatively and allow the harmonization of data. This method is user-friendly and provides a powerful solution, without complex implementations, to clean the analyses by removing variability associated with the differences between sites.

Published
2022

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