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Treball final de Màster en Investigació Sociològica Aplicada, Universitat Autònoma de Barcelona. Facultat de Ciències Polítiques i de Sociologia Aquest treball pretén explorar el rol de la xarxa comunitària com un dels agents que poden tenir un impacte en la reinserció de les persones empresonades, partint de la premissa teòrica que és difícil aconseguir el desistiment del delicte i evitar la reincidència sense un suport comunitari fort. S'ha dissenyat una investigació qualitativa amb un estudi de casos a través d'una mostra intencional de quatre entitats de la xarxa comunitària que treballen amb persones recluses i/o exrecluses a Catalunya. A través de les entrevistes a aquestes entitats, que responen a quatre tipologies segons una classificació pròpia, es pretén arribar a conèixer quins són els elements amb què es treballen des de la intervenció comunitària per ajudar a l'èxit del procés de reinserció d'aquells que han finalitzat una condemna de presó i s'enfronten a la vida en comunitat.

Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders involving age-dependent gene dysregulation. Reelin is a glycoprotein that varies its expression throughout lifetime and controls cortical patterning and synaptogenesis. Brain and plasma reelin levels have been reported to be low in adults with autism; as well as in children with autism, but only when compared to control adults. Therefore, reelin expression levels in children with autism are unclear. For this reason, we compared plasma reelin levels in children with autism and children without autism (non-ASD) of similar ages to evaluate reelin expression in ASD during childhood. Plasma samples from 19 non-ASD (8.9 +/- 0.8 years) and 40 children with autism (7.5 +/- 0.5 years) were analyzed. We found that 50% of the children with autism displayed similar plasma reelin levels to the non-ASD group. However, the remaining 50% expressed more than 30 times more reelin compared to non-ASD levels. We also show that male children with autism displayed significantly higher reelin levels than females. The clinical presentation of this subgroup could not be distinguished from that of children with autism. Epilepsy or attention-deficit/hyperactivity disorder (ADHD) was not associated to reelin levels. We conclude that the high levels of plasma reelin might be an important hallmark in a subset of children with autism, previously unnoticed. As we could not find any correlation between reelin levels and ASD clinical presentations, our results may indicate transient reelin increases in the plasma or the characterization of a group of ASD individuals with a different pathophysiology.

The Biological Institute of Sarrià, located in the Sant Ignasi (Jesuits of Sarrià school in Barcelona), was active between 1931 and 1965, and was known throughout Spain and Europe for its pioneering studies in embryology. They had different lines of study, and it was after the Spanish Civil War (1936-1939) when botany was resumed by Fr. Jaume Capell SJ, who was the main person responsible of the herbarium that currently it is conserved in the same school. The herbarium consists of 3,853 specimens, many of which explain the history and botani cal work of the Jesuits in the mid-20th century. The herbarium contains different exsiccata as the «Herbario de Frère Sennen», «Plantes d’Espagne», «Herbario escolar del Jardín Botánico de Madrid» and duplicates from the herbarium of Institut Botànic de Barcelona. The study of this collection reveals the presence of interesting specimens from the taxonomic point of view –Baccharis ×itapetiningae Malag., Valeriana longiflora Willk. var. eu-longiflora Capell & A.Bolòs and Carduus gayanus Durieu ex Willk. var. capellii Cámara– and a first cita tion in the Iberian Peninsula –Fimbristylis turkestanica (Regel) B.Fedtsch.–, as well as sheets with information of ethnobotanical interest, Institut d’Estudis Catalans per l’atorgament de la borsa d’estudis Ramon d’Alòs-Moner (2018)

Anàlisi del sistema de reducció actual implementat per a les emissions de NOx produides per la incineració de residus urbans de la Planta de Valorització de Residus de Sant Adrià del Besòs. Estudi del projecte de substitució d'aquest sistema per un basat en reactors catalítics: viabilitat, dimensionament i resultats a esperar. Aquest treball coincidirà amb la fase d'enginyeria de detall del projecte, per la qual cosa serà realitzat amb la tutorització de l'empresa pública Tractament i Selecció de Residus S.A. (TERSA).

Documento de trabajo sobre psiquiatría

Pediatric subglottic pathology still represents a challenge when it comes to choosing the right treatment. We present the management of patients followed in our center for this reason during the last 5 years.

International audience

La presente tesis doctoral consiste en un estudio histórico y literario, y la edición crítica de la comedia Carlos V en Francia de Lope de Vega. El primer capítulo corresponde al estudio histórico. Viene seguido por dos capítulos dedicados al estudio literario y la edición crítica de la obra.

The reelin signaling protein and its downstream components have been associated with synaptic plasticity and neurotransmission. The reelin signaling pathway begins with the binding of reelin to the transmembrane lipoprotein receptor apolipoprotein E receptor 2 (ApoER2), which in turns induces the sequential cleavage of ApoER2 by the sequential action of a- and ?-secretases. Using conditional-knockout mice of the catalytic component of the ?-secretase complex, presenilin 1 (PS1), we demonstrated increased brain ApoER2 and reelin protein and transcript levels, with no changes in the number of reelin-positive cells. Using the human SH-SY5Y neuroblastoma cell line, we showed that ApoER2 processing occurs in the presence of PS1, producing an intracellular ApoER2 C-terminal fragment. In addition, the pharmacologic inhibition of ?-secretase in SH-SY5Y cells led to increased reelin levels. Overexpression of ApoER2 decreased reelin mRNA levels in these cells. A luciferase reporter gene assay and nuclear fractionation confirmed that increased amounts of intracellular fragment of ApoER2 suppressed reelin expression at a transcriptional level. Chromatin immunoprecipitation experiments corroborated that the intracellular fragment of ApoER2 bound to the RELN promoter region. Our study suggests that PS1/?-secretase-dependent processing of the reelin receptor ApoER2 inhibits reelin expression and may regulate its signaling.

Presenilin-1 (PS1) is the catalytic component of the ?-secretase complex. In this study, we explore if PS1 participates in the processing of the cholinergic acetylcholinesterase (AChE). The major AChE variant expressed in the brain is a tetramer (G(4)) bound to a proline-rich membrane anchor (PRiMA). Overexpression of the transmembrane PRiMA protein in Chinese hamster ovary cells expressing AChE and treated with the ?-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester have enabled us to study whether, through its ?-secretase activity, PS1 participates in the processing of PRiMA-linked AChE. ?-Secretase inhibition led to a notable increase in the level of PRiMA-linked AChE, suggesting that ?-secretase is involved in the cleavage of PRiMA. We demonstrate that cleavage of PRiMA by ?-secretase results in a C-terminal PRiMA fragment. Immunofluorescence labeling allowed us to identify this PRiMA fragment in the nucleus. Moreover, we have determined changes in the proportion of the raft-residing AChE-PRiMA in a PS1 conditional knockout mouse. Our results are of interest as both enzymes have therapeutic relevance for Alzheimer's disease.