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1. Acetylshikonin isolated from Lithospermum erythrorhizon roots inhibits dihydrofolate reductase and hampers autochthonous mammary carcinogenesis in Δ16HER2 transgenic mice

Author

Wang, Junbiao, Iannarelli, Romilde, Pucciarelli, Stefania, Laudadio, Emiliano, Galeazzi, Roberta, Giangrossi, Mara, Falconi, Maurizio, Cui, Lishan, Navia, Aleix Marti, Buccioni, Michela, Marucci, Gabriella, Tomassoni, Daniele, Serini, Laura, Sut, Stefania, Maggi, Filippo, Dall’Acqua, Stefano, Marchini, Cristina, and Amici, Augusto

Published
2020
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14. Evaluations of thyme extract effects in human normal bronchial and tracheal epithelial cell lines and in human lung cancer cell line

Author

Santoni Giorgio, Nabissi Massimo, Nicotra Giovanna, Morelli Maria Beatrice, Iannarelli Romilde, Cardinali Claudio, Maggi Filippo, Amantini Consuelo, Valisi Matteo, and Marinelli Oliviero

Subjects
0301 basic medicine, Lung Neoplasms, medicine.drug_class, Interleukin-1beta, Anti-Inflammatory Agents, Bronchi, Inflammation, Respiratory Mucosa, Pharmacology, Toxicology, Anti-inflammatory, Cell Line, Thymus Plant, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, medicine, Humans, Interleukin 8, Lung, Thymol, Cell Death, Plant Extracts, business.industry, Interleukin-8, NF-kappa B, General Medicine, respiratory system, Antineoplastic Agents, Phytogenic, Mucus, respiratory tract diseases, Trachea, 030104 developmental biology, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, Cancer cell, Immunology, medicine.symptom, business
Abstract

Thyme (Thymus vulgaris) is used traditionally to prepare herbal remedies possessing expectorant, mucolytic, antitussive and antispasmodic properties. The aim of the present study was to investigate the effects of a standardized hydroalcoholic extract of thyme on primary human airway (bronchial/tracheal) epithelial cell lines in a model of lung inflammation induced by LPS. In addition, the effects of thyme extract on human lung cancer cell line (H460) were analysed. Thyme extract showed significant anti-inflammatory properties by reducing the NF-κB p65 and NF-κB p52 transcription factors protein levels followed by the decrease of pro-inflammatory cytokines (IL-1 beta and IL-8), and Muc5ac secretion in human normal bronchial and tracheal epithelial cells. Moreover, the extract showed cytotoxic effects on H460 cancer cells, modulated the release of IL-1 beta, IL-8 and down-regulated NF-κB p65 and NF-κB p52 proteins. Taken together, these results substantiated the traditional uses of thyme in the treatment of respiratory diseases. Thyme extract might be an effective treatment of chronic diseases based on inflammatory processes when hypersecretion of mucus overwhelms the ciliary clearance and obstructs airways, causing morbidity and mortality. Moreover thyme extract, evaluated in H460 lung cancer cell line, demonstrated to induce cell cytotoxicity in addition to reduce inflammatory cell signals.

Published
2016
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16. Identification of highly effective antitrypanosomal compounds in essential oils from the Apiaceae family

Author

Kamte, Stephane L. Ngahang, Ranjbarian, Farahnaz, Cianfaglione, Kevin, Sut, Stefania, Dall'Acqua, Stefano, Bruno, Maurizio, Afshar, Fariba Heshmati, Iannarelli, Romilde, Benelli, Giovanni, Cappellacci, Loredana, Hofer, Anders, Maggi, Filippo, Petrelli, Riccardo, Kamte, Stephane L. Ngahang, Ranjbarian, Farahnaz, Cianfaglione, Kevin, Sut, Stefania, Dall'Acqua, Stefano, Bruno, Maurizio, Afshar, Fariba Heshmati, Iannarelli, Romilde, Benelli, Giovanni, Cappellacci, Loredana, Hofer, Anders, Maggi, Filippo, and Petrelli, Riccardo

Abstract

The Apiaceae family encompasses aromatic plants of economic importance employed in foodstuffs, beverages, perfumery, pharmaceuticals and cosmetics. Apiaceae are rich sources of essential oils because of the wealth of secretory structures (ducts and vittae) they are endowed with. The Apiaceae essential oils are available on an industrial level because of the wide cultivation and disposability of the bulky material from which they are extracted as well as their relatively cheap price. In the fight against protozoal infections, essential oils may represent new therapeutic options. In the present work, we focused on a panel of nine Apiaceae species (Siler montamon, Sison amomum, Echinophora spinosa, Kundmannia sicula, Crithmum maritimum, Helosciadium nodiforum, Pimpinella anisum, Heracleum sphondylium and Trachyspermum cunmi) and their essential oils as a model for the identification of trypanocidal compounds to be used as alternative/integrative therapies in the treatment of Human African trypanosomiasis (HAT) and as starting material for drug design. The evaluation of inhibitory effects of the Apiaceae essential oils against Trypanosoma brucei showed that some of them (E. spinosa, S. amomum, C. maritimwn and H. nodifloruin) were active, with EC50 in the range 2.7-10.7 mu g/mL. Most of these oils were selective against T. brucei, except the one from C. maritimum that was highly selective against the BALB/3T3 mammalian cells. Testing nine characteristic individual components (a-pinene, sabinene, alpha-phellandrene, p-cymene, limonene, beta-ocimene, gamma-terpinene, terpinolene, and myristicin) of these oils, we showed that some of them had much higher selectivity than the oils themselves. Terpinolene was particularly active with an EC50 value of 0.035 mu g/rnL (0.26 mu M) and a selectivity index (SI) of 180. Four other compounds with EC50 in the range 1.0-6.0 mu g/mL (7.4-44 mu M) had also good SI: a-pinene (> 100), beta-ocimene (> 91), limonene (> 18) and sabi

Published
2018
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18. An overlooked horticultural crop, Smyrnium olusatrum, as a potential source of compounds effective against African trypanosomiasis

Author

Petrelli, Riccardo, Ranjbarian, Farahnaz, Dall'Acqua, Stefano, Papa, Fabrizio, Iannarelli, Romilde, Ngahang Kamte, Stephane L., Vittori, Sauro, Benelli, Giovanni, Maggi, Filippo, Hofer, Anders, Cappellacci, Loredana, Petrelli, Riccardo, Ranjbarian, Farahnaz, Dall'Acqua, Stefano, Papa, Fabrizio, Iannarelli, Romilde, Ngahang Kamte, Stephane L., Vittori, Sauro, Benelli, Giovanni, Maggi, Filippo, Hofer, Anders, and Cappellacci, Loredana

Abstract

Among natural products, sesquiterpenes have shown promising inhibitory effects against bloodstream forms of Trypanosoma brucei, the protozoan parasite causing human African trypanosomiasis (HAT). Smyrnium olusatrum (Apiaceae), also known as Alexanders or wild celery, is a neglected horticultural crop characterized by oxygenated sesquiterpenes containing a furan ring. In the present work we explored the potential of its essential oils obtained from different organs and the main oxygenated sesquiterpenes, namely isofuranodiene, germacrone and β-acetoxyfuranoeudesm-4(15)-ene, as inhibitors of Trypanosoma brucei. All essential oils effectively inhibited the growth of parasite showing IC50 values of 1.9–4.0 μg/ml. Among the main essential oil constituents, isofuranodiene exhibited a significant and selective inhibitory activity against T. brucei (IC50 of 0.6 μg/ml, SI = 30), with β-acetoxyfuranoeudesm-4(15)-ene giving a moderate potentiating effect. These results shed light on the possible application of isofuranodiene as an antiprotozoal agent to be included in combination treatments aimed not only at curing patients but also at preventing the diffusion of HAT.

Published
2017
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21. Blue honeysuckle fruit (Lonicera caerulea L. var. kamtschatica): phenolic composition, nutritional value and biological activities of its polar extracts

Author

Caprioli, Giovanni, Iannarelli, Romilde, Innocenti, Marzia, Bellumori, Maria, Fiorini, Dennis, Gianni, Sagratini, Vittori, Sauro, Michela Buccioni, Claudia Santinelli, Massimo, Bramucci, Luana, Quassinti, Giulio, Lupidi, Vitali, Luca A., Dezemona, Petrelli, Daniela, Beghelli, Clarita, Cavallucci, Onelia, Bistoni, Angelo, Trivisonno, and Filippo, Maggi

Subjects
Lonicera caerulea L
Published
2016

23. An overlooked horticultural crop, Smyrnium olusatrum, as a potential source of compounds effective against African trypanosomiasis

Author

Petrelli, Riccardo, primary, Ranjbarian, Farahnaz, additional, Dall'Acqua, Stefano, additional, Papa, Fabrizio, additional, Iannarelli, Romilde, additional, Ngahang Kamte, Stephane L., additional, Vittori, Sauro, additional, Benelli, Giovanni, additional, Maggi, Filippo, additional, Hofer, Anders, additional, and Cappellacci, Loredana, additional

Published
2017
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25. Polar extracts from the berry-like fruits of Hypericum androsaemum L. as a promising ingredient in skin care formulations

Author

Antognoni, Fabiana, primary, Lianza, Mariacaterina, additional, Poli, Ferruccio, additional, Buccioni, Michela, additional, Santinelli, Claudia, additional, Caprioli, Giovanni, additional, Iannarelli, Romilde, additional, Lupidi, Giulio, additional, Damiani, Elisabetta, additional, Beghelli, Daniela, additional, Alunno, Alessia, additional, and Maggi, Filippo, additional

Published
2017
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31. Bioactive Secondary Metabolites fromSchizogyne sericea(Asteraceae) Endemic to Canary Islands

Author

Venditti, Alessandro, primary, Bianco, Armandodoriano, additional, Muscolo, Camilla, additional, Zorzetto, Christian, additional, Sánchez-Mateo, Candelaria C., additional, Rabanal, Rosa M., additional, Quassinti, Luana, additional, Bramucci, Massimo, additional, Damiano, Silvia, additional, Iannarelli, Romilde, additional, Lupidi, Giulio, additional, Papa, Fabrizio, additional, Petrelli, Dezemona, additional, Vitali, Luca A., additional, Vittori, Sauro, additional, and Maggi, Filippo, additional

Published
2016
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32. Phenolic acids, antioxidant and antiproliferative activities of Naviglio® extracts from Schizogyne sericea (Asteraceae)

Author

Caprioli, Giovanni, primary, Iannarelli, Romilde, additional, Sagratini, Gianni, additional, Vittori, Sauro, additional, Zorzetto, Christian, additional, Sánchez-Mateo, Candelaria C., additional, Rabanal, Rosa M., additional, Quassinti, Luana, additional, Bramucci, Massimo, additional, Vitali, Luca A., additional, Petrelli, Dezemona, additional, Lupidi, Giulio, additional, Venditti, Alessandro, additional, and Maggi, Filippo, additional

Published
2016
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33. Polar Constituents and Biological Activity of the Berry-Like Fruits from Hypericum androsaemum L.

Author

Caprioli, Giovanni, primary, Alunno, Alessia, additional, Beghelli, Daniela, additional, Bianco, Armandodoriano, additional, Bramucci, Massimo, additional, Frezza, Claudio, additional, Iannarelli, Romilde, additional, Papa, Fabrizio, additional, Quassinti, Luana, additional, Sagratini, Gianni, additional, Tirillini, Bruno, additional, Venditti, Alessandro, additional, Vittori, Sauro, additional, and Maggi, Filippo, additional

Published
2016
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34. Blue honeysuckle fruit (Lonicera caerulea L.) from eastern Russia: phenolic composition, nutritional value and biological activities of its polar extracts

Author

Caprioli, Giovanni, primary, Iannarelli, Romilde, additional, Innocenti, Marzia, additional, Bellumori, Maria, additional, Fiorini, Dennis, additional, Sagratini, Gianni, additional, Vittori, Sauro, additional, Buccioni, Michela, additional, Santinelli, Claudia, additional, Bramucci, Massimo, additional, Quassinti, Luana, additional, Lupidi, Giulio, additional, Vitali, Luca A., additional, Petrelli, Dezemona, additional, Beghelli, Daniela, additional, Cavallucci, Clarita, additional, Bistoni, Onelia, additional, Trivisonno, Angelo, additional, and Maggi, Filippo, additional

Published
2016
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36. Microemulsions enhance the shelf-life and processability of Smyrnium olusatrum L. essential oil.

Author

Cespi, Marco, Quassinti, Luana, Perinelli, Diego Romano, Bramucci, Massimo, Iannarelli, Romilde, Papa, Fabrizio, Ricciutelli, Massimo, Bonacucina, Giulia, Palmieri, Giovanni Filippo, and Maggi, Filippo

Subjects
THERAPEUTIC use of essential oils, MICROEMULSIONS, LOMATIUM, HORTICULTURAL crops, CURATIVE medicine, BIOACTIVE compounds
Abstract

Smyrnium olusatrum L. is a horticultural crop cultivated during the Roman age for culinary and curative uses. The essential oil extracted from this plant (AEO) is rich in bioactive constituents such as isofuranodiene and germacrone. Several previous studies revealed that AEO and its isolated components possess interesting therapeutic features, such as antiproliferative, neuritogenic, hepatoprotective and antioxidant properties. Nevertheless, AEO has stability problems because of the high concentration of its main components. This issue makes AEO very difficult to handle and use. Thus, AEO was formulated as microemulsions known for their thermodynamic stability and easiness of preparation. AEO was hydrodistilled from inflorescences of S. olusatrum and its composition determined by different chromatographic methods. The microemulsions were developed using a central composite design and their activity tested using the MTT assay. The present study demonstrated the possibility to formulate stable AEOmicroemulsionswhere the crystallization of isofuranodiene is avoided, and the AEO biological activity is maintained. [ABSTRACT FROM AUTHOR]

Published
2017
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37. Phenolic acids, antioxidant and antiproliferative activities of Naviglio® extracts from Schizogyne sericea (Asteraceae).

Author

Caprioli, Giovanni, Iannarelli, Romilde, Sagratini, Gianni, Vittori, Sauro, Zorzetto, Christian, Sánchez-Mateo, Candelaria C., Rabanal, Rosa M., Quassinti, Luana, Bramucci, Massimo, Vitali, Luca A., Petrelli, Dezemona, Lupidi, Giulio, Venditti, Alessandro, and Maggi, Filippo

Abstract

Schizogyne sericea, well-known as ‘salado’, is a halophytic shrub widespread on coastal rocks of Tenerife (Canary Islands). This plant is used traditionally as analgesic, astringent, anti-inflammatory and vulnerary agent. In the present work, we have analysed the aqueous and ethanolic extracts ofS. sericeafor the content of phenolic acids by HPLC-DAD. The dynamic solid–liquid Naviglio® extractor was used to extract the flowering aerial parts. Aqueous extracts showed higher levels of phenolics than ethanolic extracts.S. sericeaextracts were rich in chlorogenic and isochlorogenic acids. The Naviglio® extracts obtained were assayed forin vitrobiological activities, namely antioxidant, antimicrobial and cytotoxicity on tumour cells by DPPH, ABTS, FRAP, agar disc-diffusion and MTT methods, respectively. Results showed that aqueous extracts, being richer in phenolic acids, are endowed with relevant radical scavenging activity (TEAC values in the range 208–960 μmol TE/g) while ethanolic extracts exhibited noteworthy antiproliferative effects on tumour cells. [ABSTRACT FROM PUBLISHER]

Published
2017
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38. Essential oil chemotypification and secretory structures of the neglected vegetable Smyrnium olusatrum L. (Apiaceae) growing in central Italy

Author

Maggi, Filippo, primary, Papa, Fabrizio, additional, Giuliani, Claudia, additional, Maleci Bini, Laura, additional, Venditti, Alessandro, additional, Bianco, Armandodoriano, additional, Nicoletti, Marcello, additional, Iannarelli, Romilde, additional, Caprioli, Giovanni, additional, Sagratini, Gianni, additional, Cortese, Manuela, additional, Ricciutelli, Massimo, additional, and Vittori, Sauro, additional

Published
2014
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40. Antioxidant activity and cytotoxicity on tumour cells of the essential oil from Cedronella canariensis var. canariensis (L.) Webb & Berthel. (Lamiaceae).

Author

Zorzetto, Christian, Sánchez-Mateo, Candelaria C., Rabanal, Rosa M., Lupidi, Giulio, Bramucci, Massimo, Quassinti, Luana, Iannarelli, Romilde, Papa, Fabrizio, and Maggi, Filippo

Abstract

Cedronella canariensisis a lemon-scented species of the family Lamiaceae endemic to the Canary Islands where it is used in the traditional medicine to prepare infusions or inhalations for anti-catarrhal, tonic, diuretic, hypoglycaemiant, hypotensive, anti-inflammatory and decongestant of the respiratory tract. In this work we investigated for the first time the antioxidant activity of the essential oil and its inhibitory effects on tumour cells (A375, MDA-MB-231, HCT 116) proliferation by DPPH, ABTS, FRAP and MTT assays, respectively. The oil, analysed by GC-ionisation flame detector and GC–MS, was characterised by pinocarvone (58.0%) and β-pinene (10.8%) as the major constituents, being typical of the chemotype ‘canariensis’. Noteworthy was the cytotoxic activity of the oil against the tumour cells examined, with IC50values of 4.3, 7.3 and 11.4 μg/mL on A375, MDA-MB-231 and HCT 116 tumour cells, respectively, as well as the scavenging activity against the ABTS radical (IC50of 10.5 μg/mL). [ABSTRACT FROM PUBLISHER]

Published
2015
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41. Polar extracts from the berry-like fruits of Hypericum androsaemum L. as a promising ingredient in skin care formulations

Author

Alessia Alunno, Fabiana Antognoni, Romilde Iannarelli, Daniela Beghelli, Claudia Santinelli, Filippo Maggi, Ferruccio Poli, Giulio Lupidi, Michela Buccioni, Elisabetta Damiani, Giovanni Caprioli, Mariacaterina Lianza, Antognoni, Fabiana, Lianza, Mariacaterina, Poli, Ferruccio, Buccioni, Michela, Santinelli, Claudia, Caprioli, Giovanni, Iannarelli, Romilde, Lupidi, Giulio, Maggi, Filippo, Damiani, Elisabetta, Beghelli, Daniela, and Alunno, Alessia

Subjects
Male, 0301 basic medicine, Shikimic Acid, Decoction, Berry, Pharmacology, Medicinal, chemistry.chemical_compound, Ingredient, 0302 clinical medicine, Drug Stability, Cell Movement, Drug Discovery, Leukocytes, Cells, Cultured, Chromatography, High Pressure Liquid, chemistry.chemical_classification, Chromatography, Cultured, biology, Traditional medicine, Polar constituent, Polar constituents, Middle Aged, Plants, Skin Care, Hypericum androsaemum, Hemolysis, High Pressure Liquid, 030220 oncology & carcinogenesis, Female, Chlorogenic Acid, Hypericum, Adult, Immunomodulatory, Cells, Mononuclear, Collagenase activity, Matrix Metalloproteinase Inhibitors, Fibroblast migration, 03 medical and health sciences, Chlorogenic acid, UV-protection, Collagenases, Dermatologic Agents, Fibroblasts, Fruit, Humans, Interleukin-6, Kinetics, Leukocytes, Mononuclear, Methanol, Phytotherapy, Plant Extracts, Plants, Medicinal, Solvents, Water, Wound Healing, Drug Discovery3003 Pharmaceutical Science, medicine, biology.organism_classification, medicine.disease, 030104 developmental biology, Enzyme, chemistry
Abstract

Ethnopharmacological relevance The top flowering aerial parts of the Hypericum species are traditionally used to prepare ointments to heal cuts and burns. Sometimes even the fruits are used for these purposes. Hypericum androsaemum L., commonly known as tutsan or shrubby St. John's Wort, is a Mediterranean medicinal plant which has been traditionally used to prepare an ointment for treating cuts and wounds. Aim of the study To evaluate the extracts obtained from H. androsaemum red berries as functional ingredients for skin care formulations. Materials and methods The methanolic extract was obtained by Soxhlet extraction while the aqueous extract was prepared by decoction; their composition was determined by HPLC analysis. Their biological activities were measured in terms of proliferation and migration of human fibroblasts, inhibition of collagenase activity, and immunomodulatory effects on human peripheral blood mononuclear cells (PBMCs). In addition, we evaluated their photostability by UV spectroscopy and their protective effects against APPH-induced hemolysis in red blood cells (RBC). Results The polar extracts contained significant amounts of shikimic (108,143.7–115,901.3 mg/kg) and chlorogenic acids (45,781.1–57,002.7 mg/kg). The main components of these extracts made an important contribution to a significant increase in human fibroblast migration. Both extracts were also active as collagenase inhibitors, with the aqueous one showing a greater inhibitory capacity (IC 50 value of 88.1 µg/mL), similar to that of chlorogenic acid. The kinetic parameters determined for the enzymatic reaction revealed for both aqueous extract and chlorogenic acid an uncompetitive mechanism of inhibition. The methanolic extract showed important effects on PBMCs by modulating IL-6. Both extracts proved to be photostable in the UVA/B range and protected RBC against peroxidation at low concentrations. Conclusions H. androsaemum red berries were proven to contain phytochemicals that improve skin regeneration, hence potentially employable in skin care formulations.

Published
2017

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