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Background There are conflicting recommendations between organizations regarding aminoglycoside use for the prophylaxis of type III open fractures. Study question To compare cefazolin monotherapy versus cefazolin plus aminoglycoside therapy for prophylaxis of type III open fractures in trauma patients. Study design This was a multicenter, retrospective, cohort study conducted in 3 academic medical centers in the United States. Consecutive adult trauma patients with type III open fractures between January 2014 and September 2016 were included. Patients were divided into 2 groups: (1) cefazolin monotherapy versus (2) cefazolin plus aminoglycoside. Measures and outcomes The primary outcome measure was the occurrence of infection at the open fracture site. The secondary outcome measure was the occurrence of acute kidney injury. Results There were 134 patients included in the study cohort. Of these, 39 received cefazolin monotherapy and 95 received cefazolin plus aminoglycoside. Overall, the mean age was 39 ± 15 years, 105 (78%) were male, and the most common fracture location was tibia/fibula (n = 74, 56%). Infection at the open fracture site occurred in 6 of 39 patients (15%) in the cefazolin monotherapy group and 15 of 95 patients (16%) in the cefazolin plus aminoglycoside group (P = 1.000). Acute kidney injury occurred in 0 of 39 (0%) in the cefazolin monotherapy group and 1 of 95 (1%) in the cefazolin plus aminoglycoside group (P = 1.000). Conclusions Cefazolin monotherapy may be appropriate for antimicrobial prophylaxis of type III open fractures in trauma patients.

CASE This case report discusses 2 cases of proximal femur peri-implant fractures after the use of lateral locking plates for distal femur periprosthetic fractures. CONCLUSION The use of locking plate technology for fixation of distal femur periprosthetic fractures is a common treatment modality. Although much has been reported regarding healing and complication rates of distal femoral periprosthetic fractures, little has been reported about peri-implant fractures subsequent to treatment using locking plates. We propose the importance of developing a method of fixation to protect the entire femur in osteoporotic patients sustaining distal femur periprosthetic fractures at the index surgery to avoid this complication.