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293 results on '"Iaina, Adrian"'

5. Sleep Apnoea And Hypertension

Author

Harrison, Mark, Jones, Caroline, Brabin, Elinor, Lavie, Peretz, Silverberg, Donald, Oksenberg, Arie, and Iaina, Adrian

Published
2000

10. Differential regulation of glomerular arginine transporters (CAT-1 and CAT-2) in lipopolysaccharide-treated rats

Author

Schwartz, Doron, Schwartz, Idit F., Gnessin, Ehud, Wollman, Yoram, Chernichovsky, Tamara, Blum, Miriam, and Iaina, Adrian

Subjects
Physiology -- Research, Nitric oxide -- Physiological aspects, Arginine -- Physiological aspects, Bacterial infections -- Physiological aspects, Biological sciences
Abstract

The decrease in glomerular filtration rate (GFR) that is characteristic of sepsis has been shown to result from inhibition of glomerular endothelial nitric oxide synthase (eNOS) by nitric oxide (NO) generated from the inducible isoform of NOS (iNOS). Although L-arginine is the sole precursor for NO biosynthesis, its intracellular availability in glomeruli from septic animals has never been investigated. Arginine uptake was measured in freshly harvested glomeruli from the following experimental groups: 1) untreated rats; 2) rats pretreated with LPS (4 mg/kg body wt, 4 h before experiments); 3) rats treated with LPS as above with either L-[N.sup.6]-(1-iminoethyl)lysine hydrochloride (L-NIL), a selective iNOS antagonist, or 7-nitroindazole, a selective neuronal NOS antagonist; and 4) rats treated with L-NIL only. Both glomeular and mesangial arginine transport characteristics were found compatible with a [y.sup.+] system. Arginine uptake was augmented in glomeruli from LPS-treated rats. Treatment with L-NIL completely abolished this effect whereas L-NIL alone had no effect. Similar results were obtained when primary cultures of rat mesangial cells were preincubated with LPS (10 [micro]g/ml for 24 h) with or without L-NIL. Using RT-PCR, we found that in vivo administration of LPS resulted in a significant increase in glomerular cationic amino acid transporter-2 (CAT-2) mRNA expression whereas CAT-1 mRNA was undetected. Northern blotting further confirmed a significant increase in glomerular CAT-2 by LPS. In mesangial cells, the expression of both CAT-1 and CAT-2 mRNA was augmented after incubation with LPS. In conclusion, in vivo administration of LPS augments glomerular arginine transport through upregulation of steady-state CAT-2 mRNA while downregulating CAT-1 mRNA. These results may correspond to the changes in glomerular iNOS and eNOS activity in sepsis. cationic amino acid transporter-2; sepsis; nitric oxide; arginine transport

Published
2003

30. Role of nitric oxide (EDRF) in radiocontrast acute renal failure in rats

Author

Schwartz, Doron, Blum, Miriam, Peer, Gary, Wollman, Yoram, Maree, Abed, Serban, Irina, Grosskopf, Itamar, Cabili, Shaltiel, Levo, Yoram, and Iaina, Adrian

Subjects
Acute renal failure -- Research, Nitric oxide -- Physiological aspects, Endothelium-derived relaxing factors -- Physiological aspects, Biological sciences
Abstract

Comparative studies of the function of L-arginine and nitric oxide (NO), an endothelium-derived relaxing factor (EDRF), during the pathogenesis of radiocontrast-induced acute renal problem in rats reveal that NO synthase treatment is more effective in reducing p-aminohippurate clearance and weakens the decrease in insulin clearance. C(In) recovery is more rapid in salt-depleted rats than in inhibitor- and L-arginine-treated rats, following radiocontrast treatment. Reduction in guanosine 3',5'-cyclic monophosphate levels following radiocontrast reveals the therapeutic use of L-arginine for acute failure.

Published
1994

39. Iron Management in Predialysis Patients

Author

Silverberg, Donald S., Blum, Miriam, Schwartz, Doron, Agbaria, Zodi, Yacnin, Tatiana, Steinbruch, Shoshana, Baruch, Roni, and Iaina, Adrian

Published
1999

45. The role of correction of anemia in patients with congestive heart failure associated with chronic kidney failure

Author

Silverberg, Donald S., Wexler, Dov, Iaina, Adrian, and Schwartz, Doron

Subjects
Anemia -- Health aspects, Anemia -- Care and treatment, Chronic kidney failure -- Care and treatment, Congestive heart failure -- Causes of, Congestive heart failure -- Care and treatment, Erythropoietin -- Health aspects, Erythropoietin -- Usage, Pharmaceuticals and cosmetics industries
Published
2008

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