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4. OC.07.6 COMBINATION OF MUCOSA-EXPOSURE DEVICE AND COMPUTERAIDED DETECTION FOR ADENOMA DETECTION DURING COLONOSCOPY: A RANDOMIZED TRIAL

Author

Spadaccini, M., primary, Hassan, C., additional, De Marco, A., additional, Rondonotti, E., additional, Antonelli, G., additional, Andrisani, G., additional, Lollo, G., additional, Auriemma, F., additional, Iacopini, F., additional, Facciorusso, A., additional, Maselli, R., additional, Fugazza, A., additional, Bambina, Bergna I.M., additional, Cereatti, F., additional, Mangiavillano, B., additional, Radaelli, F., additional, Di Matteo, F., additional, Gross, S., additional, Sharma, P., additional, Mori, Y., additional, Bretthauer, M., additional, Rex, D., additional, and Repici, A., additional

Published
2023
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5. OC.07.4 TEXTURE AND COLORE ENHANCING IMAGING (TXI) VERSUS HIGH DEFINITION WHITE LIGHT ENDOSCOPY FOR DETECTION OF COLORECTAL NEOPLASIA: AN INTERNATIONAL MULTICENTER RANDOMISED TRIAL

Author

Antonelli, G., primary, Bevivino, G., additional, Pecere, S., additional, Ebigbo, A., additional, Cereatti, F., additional, Azikue, N., additional, Di Fonzo, M., additional, Coppola, M., additional, Barbaro, F., additional, Caruso, A., additional, Okimoto, K., additional, Antenucci, C., additional, Matsumura, T., additional, Zerboni, G., additional, Grossi, C., additional, Meinikheim, M., additional, Papparella, G., additional, Correale, L., additional, Costamagna, G., additional, Spada, C., additional, Messman, H., additional, Hassan, C., additional, and Iacopini, F., additional

Published
2023
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7. Endoscopists performance in optical diagnosis of colorectal polyps in artificial intelligence studies

Author

Pecere, Silvia, Antonelli, G., Dinis-Ribeiro, M., Mori, Y., Hassan, Cesare, Fuccio, L., Bisschops, R., Costamagna, Guido, Jin, E. H., Lee, D., Misawa, M., Messmann, H., Iacopini, F., Petruzziello, Lucio, Repici, A., Saito, Y., Sharma, P., Yamada, M., Spada, Cristiano, Frazzoni, L., Pecere S., Hassan C., Costamagna G. (ORCID:0000-0002-8100-2731), Petruzziello L., Spada C. (ORCID:0000-0002-5692-0960), Pecere, Silvia, Antonelli, G., Dinis-Ribeiro, M., Mori, Y., Hassan, Cesare, Fuccio, L., Bisschops, R., Costamagna, Guido, Jin, E. H., Lee, D., Misawa, M., Messmann, H., Iacopini, F., Petruzziello, Lucio, Repici, A., Saito, Y., Sharma, P., Yamada, M., Spada, Cristiano, Frazzoni, L., Pecere S., Hassan C., Costamagna G. (ORCID:0000-0002-8100-2731), Petruzziello L., and Spada C. (ORCID:0000-0002-5692-0960)

Abstract

Widespread adoption of optical diagnosis of colorectal neoplasia is prevented by suboptimal endoscopist performance and lack of standardized training and competence evaluation. We aimed to assess diagnostic accuracy of endoscopists in optical diagnosis of colorectal neoplasia in the framework of artificial intelligence (AI) validation studies. Literature searches of databases (PubMed/MEDLINE, EMBASE, Scopus) up to April 2022 were performed to identify articles evaluating accuracy of individual endoscopists in performing optical diagnosis of colorectal neoplasia within studies validating AI against a histologically verified ground-truth. The main outcomes were endoscopists' pooled sensitivity, specificity, positive and negative predictive value (PPV/NPV), positive and negative likelihood ratio (LR) and area under the curve (AUC for sROC) for predicting adenomas versus non-adenomas. Six studies with 67 endoscopists and 2085 (IQR: 115–243,5) patients were evaluated. Pooled sensitivity and specificity for adenomatous histology was respectively 84.5% (95% CI 80.3%–88%) and 83% (95% CI 79.6%–85.9%), corresponding to a PPV, NPV, LR+, LR− of 89.5% (95% CI 87.1%–91.5%), 75.7% (95% CI 70.1%–80.7%), 5 (95% CI 3.9%–6.2%) and 0.19 (95% CI 0.14%–0.25%). The AUC was 0.82 (CI 0.76–0.90). Expert endoscopists showed a higher sensitivity than non-experts (90.5%, [95% CI 87.6%–92.7%] vs. 75.5%, [95% CI 66.5%–82.7%], p < 0.001), and Eastern endoscopists showed a higher sensitivity than Western (85%, [95% CI 80.5%–88.6%] vs. 75.8%, [95% CI 70.2%–80.6%]). Quality was graded high for 3 studies and low for 3 studies. We show that human accuracy for diagnosis of colorectal neoplasia in the setting of AI studies is suboptimal. Educational interventions could benefit by AI validation settings which seem a feasible framework for competence assessment.

Published
2022

9. OC.04.5 TEXTURE AND COLOR ENHANCING IMAGING (TXI) INCREASES ADENOMA DETECTION RATE IN COLONOSCOPY: INTERIM ANALYSIS OF A RANDOMIZED CONTROLLED TRIAL

Author

Antonelli, G., primary, Bevivino, G., additional, Pecere, S., additional, Cereatti, F., additional, Ebigbo, A., additional, Akizue, N., additional, Di Fonzo, M., additional, Coppola, M., additional, Barbaro, F., additional, Caruso, A., additional, Okimoto, K., additional, Antenucci, C., additional, Matsumura, T., additional, Zerboni, G., additional, Grossi, C., additional, Meinikheim, M., additional, Papparella, G., additional, Costamagna, G., additional, Spada, C., additional, Messmann, H., additional, Hassan, C., additional, and Iacopini, F., additional

Published
2022
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11. ENDOSCOPIST PERFORMANCE IN OPTICAL DIAGNOSIS OF COLORECTAL POLYPS IN ARTIFICIAL INTELLIGENCE STUDIES

Author

Pecere, S., additional, Antonelli, G., additional, Dinis-Ribeiro, M., additional, Mori, Y., additional, Hassan, C., additional, Fuccio, L., additional, Bisschops, R., additional, Costamagna, G., additional, Ji, E.H., additional, Lee, D., additional, Misawa, M., additional, Messmann, H., additional, Iacopini, F., additional, Petruzziello, L., additional, Repici, A., additional, Saito, Y., additional, Sharma, P., additional, Yamada, M., additional, Spada, C., additional, and Frazzoni, L., additional

Published
2022
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13. T06.02.13 RATE OF NON-INVASIVE COLORECTAL NEOPLASMS REFERRED TO SURGERY AS A PERFORMANCE KEY MEASURE FOR SCREENING PROGRAMS

Author

Iacopini, F., primary, Hassan, C., additional, Mattei, E., additional, Ceci, V., additional, Frontespezi, S., additional, Brighi, S., additional, Fedeli, P., additional, Angeletti, S., additional, Fanello, G., additional, D'Ovidio, V., additional, De Palo, M.G., additional, Cocco, A., additional, Forte, A., additional, Forti, G., additional, Altavilla, N., additional, Dimito, G., additional, Occhigrossi, G., additional, Di Giulio, E., additional, Bazuro, M., additional, Ballanti, R., additional, Faggiani, R., additional, Scozzarro, A., additional, Capezzuto, E., additional, Baldi, F., additional, Baiocchi, D., additional, and Barca, A., additional

Published
2020
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16. NON-INVASIVE COLORECTAL NEOPLASMS REFERRED TO SURGERY: A PERFORMANCE KEY MEASURE FOR SCREENING PROGRAMS

Author

Iacopini, F, additional, Hassan, C, additional, Frontespezi, S, additional, Mattei, E, additional, Ceci, V, additional, Brighi, S, additional, Fedeli, P, additional, Angeletti, S, additional, Fanello, G, additional, D’Ovidio, V, additional, De Palo, MG, additional, Cocco, A, additional, Forte, A, additional, Forti, G, additional, Grossi, C, additional, Altavilla, N, additional, Dimito, G, additional, Occhigrossi, G, additional, Di Giulio, E, additional, Bazuro, M, additional, Ballanti, R, additional, Faggiani, R, additional, Scozzarro, A, additional, Capezzuto, E, additional, Baldi, F, additional, Baiocchi, D, additional, Barca, A, additional, and Costamagna, G, additional

Published
2020
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30. OC.13.4 ENDOSCOPIC SUBMUCOSAL DISSECTION: NATIONAL SURVEY ON CURRENT PRACTICES, TRAINING AND OUTCOMES

Author

Maselli, R., primary, Iacopini, F., additional, Azzolini, F., additional, Petruzziello, L., additional, Manno, M., additional, De Luca, L., additional, Cecinato, P., additional, Fiori, G., additional, Staiano, T., additional, Rizzotto, E. Rosa, additional, Angeletti, S., additional, Costamagna, G., additional, Caruso, A., additional, Coppola, F., additional, Andrisani, G., additional, Edi, V., additional, Missale, G., additional, Panarese, A., additional, Mazzocchi, S., additional, Cesaro, P., additional, Campanale, M.C., additional, Occhipinti, P., additional, Tarantino, O., additional, Crosta, C., additional, Brosolo, P., additional, Sferrazza, S., additional, Rondonotti, E., additional, Amato, A., additional, Fuccio, L., additional, and Repici, A., additional

Published
2019
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31. OC.16.1 SUPERFICIAL COLORECTAL NEOPLASMS REFERRED TO SURGERY: A SCREENING POPULATION-BASED OBSERVATIONAL STUDY

Author

Iacopini, F., primary, Hassan, C., additional, Frontespezi, S., additional, Ceci, V., additional, Mattei, E., additional, Brighi, S., additional, Fedeli, P., additional, Cocco, A., additional, Angeletti, S., additional, Fanello, G., additional, D'Ovidio, V., additional, Gallina, S., additional, Forte, A., additional, Forti, G., additional, Altavilla, N., additional, Andrei, F., additional, Di Giulio, E., additional, Dimito, G., additional, Occhigrossi, G., additional, Scozzarro, A., additional, Bazuro, M., additional, Ballanti, R., additional, Baiocchi, D., additional, Faggiani, R., additional, Capezzuto, E., additional, Baldi, F., additional, Barca, A., additional, and Costamagna, G., additional

Published
2019
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35. P.05.9 SURGERY FOR NON-INVASIVE COLORECTAL NEOPLASMS IN A POPULATION-BASED SCREENING PROGRAM

Author

Iacopini, F., primary, Hassan, C., additional, Mattei, E., additional, Ceci, V., additional, Frontespezi, S., additional, Brighi, S., additional, Fedeli, P., additional, Angeletti, S., additional, Fanello, G., additional, D'Ovidio, V., additional, De Palo, M.G., additional, Cocco, A., additional, Forte, A., additional, Forti, G., additional, Elisei, W., additional, Grossi, C., additional, Altavilla, N., additional, Dimito, G., additional, Occhigrossi, G., additional, Di Giulio, E., additional, Bazuro, E., additional, Ballanti, R., additional, Faggiani, R., additional, Scozzarro, A., additional, Capezzuto, E., additional, Baldi, F., additional, Baiocchi, D., additional, and Barca, A., additional

Published
2018
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39. OC.02.6: Impact of Previous NBI Knowledge on the Improvement of Surface-Vascular Patterns Analysis after an Image-Based Training Program: A Single Center Study on Colorectal Neoplasms

Author

Desideri, F., primary, Angeletti, S., additional, Iacopini, F., additional, Esposito, G., additional, Cicchese, N., additional, Imperatrice, B., additional, Stigliano, S., additional, Archibugi, L., additional, Häfner, M., additional, and Di Giulio, E., additional

Published
2017
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42. Prognostic variables for the clinical success of flexible endoscopic septotomy of Zenker's diverticulum

Author

Costamagna, Guido, Iacopini, F, Bizzotto, A, Familiari, Pietro, Tringali, Andrea, Perri, Vincenzo, Bella, A., Costamagna, Guido (ORCID:0000-0002-8100-2731), Familiari, P (ORCID:0000-0002-5181-2928), Tringali, Andrea (ORCID:0000-0002-9614-3449), Perri, Vincenzo (ORCID:0000-0002-0551-0873), Costamagna, Guido, Iacopini, F, Bizzotto, A, Familiari, Pietro, Tringali, Andrea, Perri, Vincenzo, Bella, A., Costamagna, Guido (ORCID:0000-0002-8100-2731), Familiari, P (ORCID:0000-0002-5181-2928), Tringali, Andrea (ORCID:0000-0002-9614-3449), and Perri, Vincenzo (ORCID:0000-0002-0551-0873)

Abstract

Flexible endoscopy septotomy for Zenker's diverticulum (ZD) is an alternative to endostapling; however, long-term data are sparse and studies are heterogeneous. The aim of this study was to assess the clinical success of flexible endoscopy diverticuloscope-assisted septotomy according to all ZD-related symptoms and to identify potential prognostic variables.

Published
2016

43. Prognostic variables for the clinical success of flexible endoscopic septotomy of Zenker’s diverticulum

Author

Perri, Vincenzo, Iacopini, F, Bizzotto, A, Familiari, Pietro, Tringali, Andrea, Perri, V, Bella, A., Costamagna, G (ORCID:0000-0002-0551-0873), Tringali, Andrea (ORCID:0000-0002-9614-3449), Perri, Vincenzo, Iacopini, F, Bizzotto, A, Familiari, Pietro, Tringali, Andrea, Perri, V, Bella, A., Costamagna, G (ORCID:0000-0002-0551-0873), and Tringali, Andrea (ORCID:0000-0002-9614-3449)

Abstract

BACKGROUND AND AIMS Flexible endoscopy septotomy for Zenker's diverticulum (ZD) is an alternative to endostapling; however, long-term data are sparse and studies are heterogeneous. The aim of this study was to assess the clinical success of flexible endoscopy diverticuloscope-assisted septotomy according to all ZD-related symptoms and to identify potential prognostic variables. METHODS: A prospective database of all patients with ZD undergoing septotomy and followed up for 24 months or longer was analyzed. Septotomy was conducted by using a diverticuloscope-assisted technique. Dysphagia, regurgitation, and respiratory symptoms (during the day and at night) were scored by their weekly frequency from 0 to 3 when on a solid food diet. Clinical success (asymptomatic state) was defined as a maximum of 2 symptoms with a score of 1 (once per week). Prognostic variables of clinical success included age, sex, pretreatment total symptom score, pre- and posttreatment ZD size, and septotomy length. The Kaplan-Meier method and Cox proportional hazards model were used to calculate the crude and adjusted hazard ratio (HR). RESULTS: Septotomy was attempted and achieved in a single session in 89 patients. Clinical success at the intention-to-treat analysis was 69%, 64%, and 46% at 6, 24, and 48 months, respectively. Adverse events occurred in 3 patients: perforation in 2 (2%) and postprocedural bleeding in 1 (1%). Independent variables for failure at 6 months were a septotomy length ≤25 mm (HR 6.34) and pretreatment ZD size ≥50 mm (HR 11.08), whereas at 48 months, they were septotomy length ≤25 (HR 2.20) and posttreatment ZD size ≥10 mm (HR 2.03). Success rates for ZD ranging in size from 30 mm to 49 mm with a septotomy >25 mm were 100% and 71% at 6 months and 48 months, respectively. CONCLUSION: Flexible endoscopic septotomy for ZD is feasible and safe. Treatment success correlates with the length of the septotomy and the size of ZD, which should ultimately determine the appropriat

Published
2016

44. Development of an E-learning System for the Endoscopic Diagnosis of Early Gastric Cancer: An International Multicenter Randomized Controlled Trial

Author

Yao, K., primary, Uedo, N., additional, Muto, M., additional, Ishikawa, H., additional, Cardona, H.J., additional, Filho, E.C. Castro, additional, Pittayanon, R., additional, Olano, C., additional, Yao, F., additional, Parra-Blanco, A., additional, Ho, S.H., additional, Avendano, A.G., additional, Piscoya, A., additional, Fedorov, E., additional, Bialek, A.P., additional, Mitrakov, A., additional, Caro, L., additional, Gonen, C., additional, Dolwani, S., additional, Farca, A., additional, Cuaresma, L.F., additional, Bonilla, J.J., additional, Kasetsermwiriya, W., additional, Ragunath, K., additional, Kim, S.E., additional, Marini, M., additional, Li, H., additional, Cimmino, D.G., additional, Piskorz, M.M., additional, Iacopini, F., additional, So, J.B., additional, Yamazaki, K., additional, Kim, G.H., additional, Ang, T.L., additional, Milhomem-Cardoso, D.M., additional, Waldbaum, C.A., additional, Carvajal, W.A. Piedra, additional, Hayward, C.M., additional, Singh, R., additional, Banerjee, R., additional, Anagnostopoulos, G.K., additional, and Takahashi, Y., additional

Published
2016
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49. Curative endoscopic submucosal dissection of large nonpolypoid superficial neoplasms in ulcerative colitis (with videos)

Author

Iacopini, F, Saito, Y, Yamada, M, Grossi, C., Rigato, P, Costamagna, Guido, Gotoda, T, Matsuda, T, Scozzarro, A., Costamagna, Guido (ORCID:0000-0002-8100-2731), Iacopini, F, Saito, Y, Yamada, M, Grossi, C., Rigato, P, Costamagna, Guido, Gotoda, T, Matsuda, T, Scozzarro, A., and Costamagna, Guido (ORCID:0000-0002-8100-2731)

Abstract

Endoscopic resection of superficial neoplasms in inflammatory bowel disease (IBD) is appropriate if a complete resection can be achieved. However, EMR is ineffective for large, nonpolypoid neoplasms in IBD due to submucosal fibrosis, and no data are available on the efficacy of endoscopic submucosal dissection (ESD).

Published
2015

50. Prevalence of nonpolypoid colorectal neoplasia: an italian multicenter observational study

Author

Bianco, Ma, Cipolletta, L, Rotondano, G, Buffoli, F, Gizzi, G, Tessari, F, Crotta, S, Strini, G, Orsello, M, Ballare, M, Gallo, M, Salacone, P, Asnaghi, G, Manca, A, Rizzi, R, Predebon, S, Quattrone, P, Vanni, R, Di Placido, R, Bastardini, R, Cristoni, Mv, Praiano, F, Meroni, E, Fasoli, A, Coccia, G, Allegretti, A, Manes, G, Cesari, P, Rolfi, F, Zambelli, A, Manfredi, G, Lisi, S, Cestari, R, Lancini, Gp, Crosta, C, Fiori, G, De Roberto, G, Dal Fante, M, Fazzini, L, Dinelli, M, Frego, R, Parente, F, Bargiggia, S, Paggi, S, Viale, E, Testoni, Pa, Iiritano, E, Andrian, G, Dinca, M, Germana, B, Lecis, P, Cappiello, R, Sablich, R, Tonello, C, Buri, L, Cannizzaro, R, Maiero, S, Fasoli, R, Ceroni, L, Eusebi, Lh, Iori, V, Tioli, C, Villani, V, Cortini, C, Maltoni, S, Forti, E, Solmi, L, Giovanardi, M, Calella, F, Tarantino, O, Widmayer, C, Silvestrelli, M, Bou Serhal, T, Feliciangeli, G, Tombesi, G, Anti, M, Pastorelli, A, Costamagna, G, Petruzziello, L, Cesaro, P, De Masi, E, Errico, A, Di Giulio, E, Carnuccio, A, Gabbrielli, Armando, Pandolfi, M, Lamazza, A, Femia, S, Morini, S, Lorenzetti, R, Del Vecchio Blanco, G, Grasso, E, Ferrara, M, Apuzzo, M, Iacopini, F, Milano, A, Balatsinou, C, Spadaccini, A, Silla, M, Ingrosso, M, Pirozzi, Ga, De Luca, L, De Bellis, M, Tempesta, A, De Palma GD, Siciliano, S, Di Giorgio, P, Giannattasio, F, Galloro, G, Grimaldi, E, Ciarleglio, A, Sarrantonio, G, Delle Cave, M, Lamanda, R, De Stefano, S, Labianca, O, Maisto, T, Montanaro, F, Pasquale, L, Di Girolamo, E, Piscopo, R, De Seta, M, Romano, M, Borgheresi, P, Gravina, Ag, Sarracco, P, Scaglione, G, Marmo, R, Salerno, R, Gentile, M, Annese, V, Della Valle, N, Muscatiello, N, Di Matteo, G, Giorgio, P, Fregola, G, Quatraro, F, Pisani, A, Tonti, P, Stoppino, G, Corazza, L, D'Ascoli, B, Ciuffi, M, Ignomirelli, O, Giglio, A, Rodino, S, Scanu, Am, Loriga, P, Murgia, R, Giacobbe, G, Grande, D, Montalbano, L, Linea, C., Bianco, Ma, Cipolletta, L, Rotondano, G, Buffoli, F, Gizzi, G, Tessari, F, Testoni, PIER ALBERTO, Flat Lesions Italian, Network, DE PALMA, GIOVANNI DOMENICO, Ma, Bianco, L., Cipolletta, G., Rotondano, F., Buffoli, G., Gizzi, F., Tessari, Romano, Marco, Gravina, A. G., Maria Antonia, Bianco, Livio, Cipolletta, Gianluca, Rotondano, Federico, Buffoli, Giuseppe, Gizzi, Francesco, Tessari, and Galloro, Giuseppe

Subjects
Male, medicine.medical_specialty, Colorectal cancer, Prevalence, Colonic Polyps, Colonoscopy, Colorectal Neoplasm, colonoscopy, flat lesions, colorectal neoplasia, Gastroenterology, Internal medicine, Epidemiology, medicine, Humans, Prospective Studies, Aged, Intraepithelial neoplasia, medicine.diagnostic_test, business.industry, Cancer, Histology, Middle Aged, medicine.disease, Colonic Polyp, Prospective Studie, Italy, Observational study, Female, Colorectal Neoplasms, business, Human
Abstract

BACKGROUND AND STUDY AIM: The aim of this study was to assess the prevalence of nonpolypoid lesions (NPLs) in Italy and their risk of containing neoplasia or advanced histology. PATIENTS AND METHODS: This was a multicenter cross-sectional observational study on consecutive patients undergoing total colonoscopy over a 3-month period in 80 Italian centers. RESULTS: In all, 27,400 total colonoscopies were analyzed. Cancer was diagnosed in 801 patients (2.9 %). A total of 6553 precancerous lesions were detected in 5609 patients. Of these, 4154 patients (74.1 %) had polypoid lesions and 1455 patients (25.9 %) had NPLs. Therefore, the prevalence of NPLs was 5.3 % (95 %CI 5.0 - 5.6). NPLs larger than 10 mm were detected in 254 patients (17.5 %). NPLs were more predominant in the proximal colon (OR 2.92, 95 %CI 2.56 - 3.43; P < 0.0001 vs. polypoid lesions). Neoplastic tissue was diagnosed in 79.0 % and advanced histology (high-grade intraepithelial neoplasia or more) in 20.9 % of resected lesions. The risk of advanced histology was similar for polypoid and nonpolypoid lesions when adjusted for size. Depressed lesions had the highest risk of advanced histology (OR 10.56, 95 %CI 6.02 - 18.55; P < 0.0000 vs. flat-elevated). Age was an independent predictor of both neoplasia and advanced histology ( P = 0.0001). CONCLUSIONS: NPLs are relatively common in the Italian population, with a prevalence similar to that in other Western series. NPLs are not more aggressive than polypoid lesions, except for those with depressed morphology. Georg Thieme Verlag KG Stuttgart. New York.

Published
2010

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