1. Seasonality in the manifestation of type 1 diabetes varies according to age at diagnosis in Finnish children
- Author
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Finnish Pediat Diabet Register, Turtinen, Maaret, Härkönen, Taina, Ilonen, Jorma, Parkkola, Anna, Knip, Mikael, HUS Children and Adolescents, Children's Hospital, Clinicum, CAMM - Research Program for Clinical and Molecular Metabolism, Molecular and Integrative Biosciences Research Programme, Lastentautien yksikkö, Research Group Knip, Tampere University, and Department of Paediatrics
- Subjects
RISK ,Adolescent ,type 1 diabetes ,AUTOIMMUNITY ,Incidence ,CHILDHOOD ,General Medicine ,3121 Internal medicine ,CLINICAL ONSET ,MELLITUS ,HLA class II ,Diabetes Mellitus, Type 1 ,3123 Gynaecology and paediatrics ,Pediatrics, Perinatology and Child Health ,Humans ,ISLET-CELL-ANTIBODIES ,IDDM ,GENDER ,Seasons ,Child ,clinical characteristics ,season ,Finland ,Autoantibodies - Abstract
AIM: We tested the hypothesis of a more aggressive disease process at diagnosis of type 1 diabetes during fall and winter, the colder seasons with consistently observed higher incidence of type 1 diabetes. METHODS: Seasonality in the manifestation of type 1 diabetes was examined in 4993 Finnish children and adolescents. Metabolic characteristics, beta-cell autoantibodies and HLA class II genetics were analysed at clinical diagnosis. RESULTS: Significant seasonality was observed with higher number of new cases during fall and winter (n = 1353/27.1% and n = 1286/25.8%) compared with spring and summer (n = 1135/22.7% and n = 219/24.4%) (p
- Published
- 2022
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