1. High-resolution contrast-enhanced MRI of atherosclerosis with digital cardiac and respiratory gating in mice
- Author
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Jacques Felblinger, Hasan Alsaid, Odette Fokapu, Yannick Crémillieux, Emmanuelle Canet-Soulas, Zakaria Bendahmane, André Briguet, Catherine Desbleds-Mansard, Claire Corot, Maher Sabbah, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Biomécanique et génie biomédical (BIM), Centre National de la Recherche Scientifique (CNRS), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Guerbet Research, IPA Program - Rhône-Alpes Region, and Felblinger, Jacques
- Subjects
Male ,Image quality ,Contrast Media ,MESH: Magnetic Resonance Angiography ,Gating ,atherosclerotic plaque ,cardiorespiratory gating ,MESH: Signal Processing, Computer-Assisted ,Signal ,030218 nuclear medicine & medical imaging ,MESH: Atherosclerosis ,Electrocardiography ,0302 clinical medicine ,Heart Rate ,Heterocyclic Compounds ,Demodulation ,Medicine ,MESH: Animals ,Respiratory system ,MESH: Heart Rate ,Image resolution ,[INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM] ,[SDV.BIBS] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] ,Signal Processing, Computer-Assisted ,contrast agent ,[SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] ,MESH: Reproducibility of Results ,MESH: Artifacts ,MESH: Respiratory Mechanics ,Radiology ,MESH: Image Enhancement ,Artifacts ,medicine.medical_specialty ,mice ,MESH: Heterocyclic Compounds ,Sensitivity and Specificity ,03 medical and health sciences ,MESH: Mice, Inbred C57BL ,MESH: Contrast Media ,Organometallic Compounds ,Animals ,Radiology, Nuclear Medicine and imaging ,aortic arch and carotids ,MESH: Mice ,Digital signal processing ,business.industry ,Reproducibility of Results ,Cardiorespiratory fitness ,MESH: Organometallic Compounds ,Atherosclerosis ,Image Enhancement ,MESH: Sensitivity and Specificity ,MESH: Male ,MESH: Electrocardiography ,Mice, Inbred C57BL ,Respiratory Mechanics ,[INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM] ,business ,Magnetic Resonance Angiography ,030217 neurology & neurosurgery ,Biomedical engineering - Abstract
International audience; Atherosclerosis initially develops predominantly at the aortic root and carotid origin, where effective visualization in mice requires efficient cardiac and respiratory gating. The present study sought to first compare the high-resolution MRI gating performance of two digital gating strategies using: 1) separate cardiac and respiratory signals (double-sensor); and 2) a single-sensor cardiorespiratory signal (ECG demodulation), and second, to apply an optimized processing technique to dynamic contrast-enhanced (CE) carotid origin vessel-wall imaging in mice. High-resolution MR mouse heart and aortic arch images were acquired by ECG signal detection, digital signal processing, and gating signal generation modeled using Simulink (MathWorks, USA). Double-sensor gating used a respiratory sensor while single-sensor gating used breathing-modulated ECG to generate a demodulated respiratory signal. Pre- and postcontrast T(1)-weighted images were acquired to evaluate vessel-wall enhancement with a gadolinium blood-pool agent (P792; Guerbet, France) at the carotid origin in vivo in ApoE(-/-) and C57BL/6 mice, using the optimized cardiorespiratory gating processing technique. Both strategies provided images with improved spatial resolution, less artifacts, and 100% correct transistor-to-transistor logic (TTL) signals. Image quality allowed vessel-wall enhancement measurement in all the ApoE(-/-) mice, with maximal (32%) enhancement 27 min postinjection. The study demonstrated the efficiency of both cardiorespiratory gating strategies for dynamic contrast-enhanced vessel-wall imaging.
- Published
- 2007