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1. ChemInform Abstract: 3,5-Diphenyl-1H-pyrazole Derivatives. Part 6. Esters and 2- Dialkylaminoethyl Ethers of 1-(2-Hydroxy-2-phenylethyl)-3,5-diphenyl- 1H-pyrazole and N,N-Disubstituted 1-(2-Amino-2-phenylethyl)-3,5- diphenyl-1H-pyrazoles with Depressant a

Author

BONDAVALLI, F., primary, BRUNO, O., additional, RANISE, A., additional, SCHENONE, P., additional, LOSASSO, C., additional, STELLA, L., additional, DE PAOLA, C., additional, IOIA, N., additional, and MARMO, E., additional

Published
2010
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4. 3,5-Diphenyl-1H-pyrazole derivatives. VI--Esters and 2-dialkylaminoethyl ethers of 1(2-hydroxy-2-phenylethyl)-3,5-diphenyl-1H-pyrazole and N,N-disubstituted 1-(2-amino-2-phenylethyl)-3,5-diphenyl-1H-pyrazoles with depressant and platelet antiaggregating activities.

Author

Bondavalli F, Bruno O, Ranise A, Schenone P, Losasso C, Stella L, de Paola C, Ioia N, and Marmo E

Subjects
Anesthetics, Local chemical synthesis, Animals, Anti-Arrhythmia Agents chemical synthesis, Anti-Inflammatory Agents, Non-Steroidal chemical synthesis, Antihypertensive Agents chemical synthesis, Chemical Phenomena, Chemistry, Humans, In Vitro Techniques, Mice, Motor Activity drug effects, Pyrazoles pharmacology, Rats, Central Nervous System Depressants chemical synthesis, Platelet Aggregation drug effects, Platelet Aggregation Inhibitors chemical synthesis, Pyrazoles chemical synthesis
Abstract

The syntheses of 1-(2-hydroxy-2-phenylethyl)-3,5-diphenyl-1H-pyrazole 1 by reaction of 2-hydrazino-1-phenylethanol with dibenzoylmethane, of esters 2 and 2-dialkylaminoethyl ethers 3 starting from 1 as sodium salt and acyl chlorides or 2-chloroethyldialkylamines, respectively, as well as of N,N-disubstituted 1-(2-amino-2-phenylethyl)-3,5-diphenyl-1H-pyrazoles 5 by reaction of secondary amines with the tosylate of 1, are described. Some of the above compounds showed a considerable sedative effect in mice and a remarkable platelet antiaggregating activity in vitro, as well as moderate local anesthetic, analgesic and antiinflammatory activities in mice and rats.

Published
1990

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