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Human lice have long been parasites of humans and are responsible for several epidemics in human medical history. However, their morphology, particularly head and body lice, remains very similar. In this study, we discriminate human louse species based on the number, shape and size of aeropyles (respiratory pores) of the egg operculum as well as the size of the respiratory orifice in the aeropyles. For this purpose, lice and eggs were collected from infested patients referring to Parasitology Department of Avicenne Hospital (Bobigny, France) and analyzed morphologically. The microscopic examination of the aeropyles revealed a large variation in the number ranging from 5 to 12 for head lice, 10 to 16 for body lice and 13 to 18 for pubic lice with a statistically distinct average of 8.3, 12.9 and 15.7, respectively. Although the length of the head and body louse eggs were almost similar, the width of body louse eggs were bigger than those of head louse (412.9 μm and 363.5 μm, respectively), while pubic louse eggs had the smallest length (692.9 μm) and width (286.1 μm). In addition, pubic louse eggs had a greater operculum length and width (253.7 μm length and 220.7 μm width) than head (230.6 μm length and 210.2 μm width) and body lice (227.9 μm length and 199.9 μm width). Moreover, pubic lice had the smallest average aeropyle size (41.2 μm) compared to head (51.1 μm) and body lice (49.1 μm). The respiratory orifice on the aeropyles of head and body lice (9.9 μm) were almost twice as big as those of pubic lice (4.9 μm). There was an inverse correlation between the number of aeropyles and their size in head, body and pubic lice. These findings are helpful in accurate identification of human louse species using their eggs, which could be useful for control management strategies against these ectoparasites. [ABSTRACT FROM AUTHOR]

Introduction: Following lung transplantation (LTx), it is important for recipients to comply with immunosuppressive treatment and cope with related problems. In the post-LTx period, the course of dyspnea and psychological problems it causes in case of progression are not known. Depression and anxiety may develop in recipients after LTx. However, the relationship between this situation and treatment compliance and dyspnea is uncertain. Objective: The aim of this study was to investigate dyspnea, anxiety, and depression levels of recipients following LTx and their immunosuppressive treatment compliance. Method: The study was planned as a descriptive, correlational, and cross-sectional study. Data were collected on various social media platforms via an online interview, and 65 LTx recipients were included in the sample (n = 65). A Participant Information Form, the Modified Borg Scale, the Beck Anxiety Inventory, the Beck Depression Inventory, and the Immunosuppressive Drug Compliance Scale were employed to collect data. The collected data were analyzed using descriptive statistics, the Mann–Whitney U test, and the Kruskal-Wallis test. Results: The mean age of the participants was found to be 52.60 ± 9.44 years, and 56.9% were male. Forty percent of the participants were dependent on oxygen support, and 32.2% had hypertension. Their dyspnea levels were mild, anxiety levels were moderate, depression levels were high, and immunosuppressive treatment compliance levels were slightly above-average. According to the correlation analysis results, dyspnea was associated with anxiety and depression (p < 0.05). As depression increased, immunosuppressive treatment compliance decreased, and the correlation between the two variables was statistically significant (p < 0.05). Conclusion: In this study, as the severity of dyspnea experienced by LTRs increased, the severity of their anxiety and depression also increased. Additionally, there was an inverse correlation between depression and immunosuppressive treatment compliance. LTRs demonstrated insufficient adherence to their immunosuppressive drug regimens, which is very significant in terms of graft survivability. These results suggest that LTRs should be closely monitored at home. [ABSTRACT FROM AUTHOR]

Background: The relationship between sex steroid hormones and high-sensitivity C-reactive protein(hs-CRP) levels in American children and adolescents is understudied. This research will examine this association. Methods: The study conducted a data analysis from the National Health and Nutrition Examination Survey (NHANES) 2015-2016, adjusting multiple linear regression models with R 4.2.2 and EmpowerStats. A total of 1,768 children and adolescents were surveyed. Data collection involved measurements of serum levels of testosterone, estradiol, sex hormone-binding globulin (SHBG) and hs-CRP. Results: With the increase in testosterone, a brief rise (β=0.082, P=0.047) followed by an overall decline (β=-0.028, P=0.023) in hs-CRP was observed in the Male Prepubertal population, while a continuous decline (β=-0.002, P<0.05) was seen in the Male Pubertal group. A positive correlation (β=0.047, P<0.05) was found between testosterone and hs-CRP in the Female Prepubertal population, whereas no significant association (β=0.002, P>0.05) was detected in the Female Pubertal group. A significant inverse correlation was observed between estradiol and hs-CRP solely in the Female Pubertal group (β=-0.002, P<0.05), while no association was found in other populations. An inverse relationship between SHBG and hs-CRP was consistently noted across all groups: Male Prepubertal, Male Pubertal, Female Prepubertal, and Female Pubertal. Conclusions: The association between sex steroid hormones and high-sensitivity C-reactive protein (hs-CRP) levels among American children and adolescents is conditional and influenced by multiple factors. [ABSTRACT FROM AUTHOR]

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Background: 25-hydroxyvitamin D is the body's main storage form of vitamin D and is internationally recognized as the best indicator of vitamin D status in the human body. There is a scarcity of research investigating the interrelationship between serum 25-hydroxyvitamin D (25(OH)D) levels and mortality among elderly individuals with hyperlipidemia. To address this knowledge gap, we examined the association between serum 25(OH)D levels and mortality in an older hyperlipidemic population from NHANES, while controlling for other influential factors. The study sought to elucidate the correlation between serum 25(OH)D levels and mortality about all-cause mortality, cardiovascular disease (CVD), malignant neoplasms, and mortality from other causes. Methods: The data from NHANES 2001-2016, including 9,271 participants were analyzed to examine the association between serum 25(OH)D levels and mortality. The interrelationship was illustrated using Kaplan-Meier curves and restricted cubic splines, while the Cox proportional hazards model was utilized to estimate the multifactor adjusted hazard ratio (HR). Results: This study included 9,271 participants (43.28% male) with an average age of 69.58 years, and the average duration of participant follow-up was 88.37 months. Kaplan-Meier curves demonstrated that lower serum 25(OH)D levels were associated with increased risks of all-cause mortality, cardiovascular mortality, malignant neoplasm mortality, and mortality from other causes. This negative association was further confirmed by the Cox proportional hazards models. Additionally, restricted cubic splines not only revealed this negative association but also highlighted the saturated serum 25(OH)D levels. Moreover, subgroup analyses indicated that the inverse correlation between serum 25(OH) D levels and all-cause mortality was more pronounced in the non-obese and smoking population. And the inverse correlation with mortality from other causes was even stronger in the non-obese population. Conclusions: In the elderly population with hyperlipidemia, 25(OH)D serum levels were negatively correlated with both cause-specific mortality and all-cause mortality. Moreover, there was a threshold effect in this negative association. [ABSTRACT FROM AUTHOR]

In recent years, organic solar cells (OSCs) have shown high power efficiencies approaching 20%. However, the fundamental mechanisms of charge separation in these highly efficient devices have been a subject of intensive debates. Here, the charge separation efficiency (CSE) is extensively investigated across a wide range of blend systems with different energetic offsets. The findings unveil the temperature‐dependent nature of charge separation in low‐offset systems, emphasizing its significant contribution to the overall CSE. An intriguing inverse correlation between CSE and charge separation activation energy in relation to the offset is also observed. These results shed new light on the factors underlying the high CSE observed in the state‐of‐the‐art devices. [ABSTRACT FROM AUTHOR]

The radial velocity (RV) method of exoplanet detection requires mitigation of nuisance signals arising from stellar activity. Using analytic cool and facular spot models, we explore the use of central line moments (CLMs) for recovering and monitoring rotation induced RV variability. Different spot distribution patterns, photosphere-spot contrast ratios, and the presence or absence of the convective blueshift lead to differences in CLM signals between M and G dwarfs. Harmonics of the rotation period are often recovered with the highest power in standard periodogram analyses. By contrast, we show the true stellar rotation may be more reliably recovered with string length minimization. For solar minimum activity levels, recovery of the stellar rotation signal from CLMs is found to require unfeasibly high signal-to-noise observations. The stellar rotation period can be recovered at solar maximum activity levels from CLMs for reasonable cross-correlation function (CCF) signal-to-noise ratios >1000–5000. The CLMs can be used to recover and monitor stellar activity through their mutual correlations and correlations with RV and bisector inverse span. The skewness of a CCF, a measure of asymmetry, is described by the third CLM, |$M_3$|⁠. Our noise-free simulations indicate the linear RV versus |$M_3$| correlation is up to 10 per cent higher than the RV versus bisector inverse span correlation. We find a corresponding ∼5 per cent increase in linear correlation for CARMENES observations of the M star, AU Mic. We also assess the effectiveness of the time derivative of the second CLM, |$M_2$|⁠ , for monitoring stellar activity. [ABSTRACT FROM AUTHOR]

This study examined the relationships between factors contributing to high school students’ mathematics achievement. Three hundred fourteen high school students participated in the study. We collected the data through the “Self‐Efficacy Scale for Mathematics Literacy,” “Bidimensional Mathematics Anxiety Scale,” “Mathematics Self‐Efficacy Scale,” “Attitudes Towards Mathematics Scale Short Form,” and mathematics exams. For this purpose, we proposed a theoretical model and tested the assumptions based on the model with path analysis. The results showed a positive and significant relationship between mathematical literacy self‐efficacy with mathematics self‐efficacy perception and attitudes towards mathematics. In addition, mathematics self‐efficacy perception had a positive and significant relationship with attitudes towards mathematics and a negative and significant relationship with mathematics anxiety. Also, attitudes towards mathematics had a positive and significant relationship with mathematics achievement, and mathematics anxiety had a negative and significant relationship with mathematics achievement. For every individual to use mathematics to meet basic life skills, all stakeholders of education, especially teachers, need to understand its importance, resources and how they can empower individuals in this aim. The relationships revealed in this study will serve the development of this understanding. [ABSTRACT FROM AUTHOR]

Background: Delirium affects 50–85% of patients on mechanical ventilation and is associated with increased mortality, prolonged hospitalization, and a three-fold higher risk of dementia. Microglia, the resident immune cells of the brain, exhibit both neuroprotective and neurotoxic functions; however, their effects in mechanical ventilation-induced acute lung injury (VILI) are unknown. We hypothesize that in a model of short-term VILI, microglia play a neuroprotective role to ameliorate delirium-like phenotypes. Methods: Microglia depletion (n = 18) was accomplished using an orally administered colony stimulating factor 1 receptor inhibitor, while controls received a vehicle diet (n = 18). We then compared extent of neuronal injury in the frontal cortex and hippocampus using cleaved caspase-3 (CC3) and multiple delirium-like behaviors in microglia depleted and non-microglia depleted male mice (C57BL/6 J aged 4–9 months) following VILI. Delirium-like behaviors were evaluated using the Open Field, Elevated Plus Maze, and Y-maze assays. We subsequently evaluated whether repopulation of microglia (n = 14 repopulation, 14 vehicle) restored the phenotypes. Results: Frontal/hippocampal neuronal CC3 levels were significantly higher in microglia depleted VILI mice compared to vehicle-treated VILI controls (p < 0.01, p < 0.01, respectively). These structural changes were accompanied by worse delirium-like behaviors in microglia depleted VILI mice compared to vehicle controls. Specifically, microglia depleted VILI mice demonstrated: (1) significantly increased time in the periphery of the Open Field (p = 0.01), (2) significantly increased coefficient of variation (p = 0.02), (3) trend towards reduced time in the open arms of the Elevated Plus Maze (p = 0.09), and (4) significantly decreased spontaneous alternations on Y-maze (p < 0.01). There was a significant inverse correlation between frontal CC3 and percent spontaneous alternations (R2 = 0.51, p < 0.01). Microglia repopulation showed a near-complete return to vehicle levels of delirium like-behaviors. Conclusions: This study demonstrates that microglia depletion exacerbates structural and functional delirium-like phenotypes after VILI, while subsequent repopulation of microglia restores these phenotypes. These findings suggest a neuroprotective role for microglia in ameliorating neuronal and functional delirium-like phenotypes and call for consideration of interventions that leverage endogenous microglia physiology to mitigate delirium. [ABSTRACT FROM AUTHOR]

The development and progression of chronic lymphocytic leukemia (CLL) depend on genetic abnormalities and on the immunosuppressive microenvironment. We have explored the possibility that genetic drivers might be responsible for the immune cell dysregulation that shapes the protumor microenvironment. We performed a transcriptome analysis of coding and non-coding RNAs (ncRNAs) during leukemia progression in the Rag2−/−γc−/− MEC1-based xenotransplantation model. The DLEU2/miR-16 locus was found downmodulated in monocytes/macrophages of leukemic mice. To validate the role of this cluster in the tumor immune microenvironment, we generated a mouse model that simultaneously mimics the overexpression of hTCL1 and the germline deletion of the minimal deleted region (MDR) encoding the DLEU2/miR-15a/miR-16-1 cluster. This model provides an innovative and faster CLL system where monocyte differentiation and macrophage polarization are exacerbated, and T-cells are dysfunctional. MDR deletion inversely correlates with the levels of predicted target proteins including BCL2 and PD1/PD-L1 on murine CLL cells and immune cells. The inverse correlation of miR-15a/miR-16-1 with target proteins has been confirmed on patient-derived immune cells. Forced expression of miR-16-1 interferes with monocyte differentiation into tumor-associated macrophages, indicating that selected ncRNAs drive the protumor phenotype of non-malignant immune cells. [ABSTRACT FROM AUTHOR]

Introduction: The intricate roles of immune cells and inflammatory factors in cancer, particularly their association with the risk of bladder cancer, are not well understood. Methods: This study aimed to clarify potential causal relationships between these elements and the development of bladder cancer using genome-wide association study (GWAS) summary statistics for 731 immune cell phenotypes and 91 circulating inflammatory factors (cases=2,053; controls=287,137). The primary analytical approach was Inverse Variance Weighting (IVW), supplemented by MR-Egger regression, weighted median, and weighted mode analyses. Sensitivity analyses included Cochran Q test, MR-Egger intercept test, and Leave-one-out test. Results: The findings indicated that monocytes are positively correlated with an increased risk of bladder cancer. On the contrary, double-negative (DN) T cells, HLA DR+CD8br, and CD28 on CD28+CD45RA+CD8br T cells exhibited an inverse correlation, suggesting a possible protective effect. Furthermore, inflammatory factors IL-20, IL-22RA1, and Eotaxin were significantly associated with an increased risk of bladder cancer. Discussion: These results suggest that certain immune cell phenotypes and inflammatory factors may play a role in the development of bladder cancer and could serve as potential biomarkers for assessing tumor risk. The findings also offer new insights into the pathogenesis of bladder cancer, indicating a need for further investigation. [ABSTRACT FROM AUTHOR]

The Vilcanota is the second-largest snow-capped mountain range in Peru, featuring 380 individual glaciers, each with its own unique characteristics that must be studied independently. However, few studies have been conducted in the Vilcanota range to monitor and track the area and volume changes of the Suyuparina and Quisoquipina glaciers. Notably, there are only a few studies that have approached this issue using LIDAR technology. Our methodology is based on a combination of optical, radar and LIDAR data sources, which allowed for constructing coherent temporal series for the both the perimeter and volume changes of the Suyuparina and Quisoquipina glaciers while accounting for the uncertainty in the perimeter detection procedure. Our results indicated that, from 1990 to 2013, there was a reduction in snow cover of 12,694.35 m2 per year for Quisoquipina and 16,599.2 m2 per year for Suyuparina. This represents a loss of 12.18% for Quisoquipina and 22.45% for Suyuparina. From 2006 to 2013, the volume of the Quisoquipina glacier decreased from 11.73 km3 in 2006 to 11.04 km3 in 2010, while the Suyuparina glacier decreased from 6.26 km3 to 5.93 km3. Likewise, when analyzing the correlation between glacier area and precipitation, a moderate inverse correlation (R = −0.52, p < 0.05) was found for Quisoquipina. In contrast, the correlation for Suyuparina was low and nonsignificant, showing inconsistency in the effect of precipitation. Additionally, the correlation between the snow cover area and the annual mean air temperature (R = −0.34, p > 0.05) and annual minimum air temperature (R = −0.36, p > 0.05) was low, inverse, and not significant for Quisoquipina. Meanwhile, snow cover on Suyuparina had a low nonsignificant correlation (R = −0.31, p > 0.05) with the annual maximum air temperature, indicating a minimal influence of the measured climatic variables near this glacier on its retreat. In general, it was possible to establish a reduction in both the area and volume of the Suyuparina and Quisoquipina glaciers based on freely accessible remote sensing data. [ABSTRACT FROM AUTHOR]

Introduction Methods Results Conclusion While there are no widely accepted diversity, equity, and inclusion (DEI) metrics for journals, geographic and sex diversity across a journal's editorial board may provide a surrogate measure of its commitment to DEI. We explored the association between journal quality and DEI metrics for cardiothoracic surgery (CTS) journals and investigated whether editorial diversity correlates with diversity across published articles.We collected the following data for 30 CTS journals: country of publication (categorized by income level), journal quality metrics (citation‐based metrics, e.g., impact factor (IF) or H‐index), and sex and geographic representation across editorial boards and published articles. Bivariate correlations between numeric variables were assessed using Spearman's correlation.Female representation across editorial boards was 12.1%. Most editorial board members belonged to the United States (35.2%), with only 7.4% from the lower‐middle‐income countries and 0% from low‐income countries. IF showed a strong positive correlation with female editorial representation (r = 0.70) but an inverse correlation with low‐ and middle‐income countries (LMICs) editorial representation (r = −0.45). Female editorial representation demonstrated a significant positive correlation with female first authorship (r = 0.45), whereas LMIC editorial representation correlated strongly with LMIC corresponding authorship (r = 0.85).Women and researchers from LMICs are in the minority across editorial boards of CTS journals. However, a strong correlation between journal H‐index and female editorial representation indicates that top‐ranked journals are spearheading efforts to improve equitable sex‐based and gender representations. Similar efforts are required to ensure more global geographic representation across editorial boards and top‐ranked CTS journals are the best placed to lead by example. [ABSTRACT FROM AUTHOR]

Codium fragile (CF) contains various bioactive compounds, but its high salt content (39.8%) makes its use as a functional food challenging. Here, we aimed to optimize the desalination process and verify changes in functionality based on variations in salt and total phenolic contents. To optimize the CF immersion conditions for the lowest salt content and monitor the total phenolic content, a response surface methodology was used. The optimal immersion conditions were as follows: X1 (immersion temperature) = 42.8 °C; X2 (immersion time) = 1.0 h. An inverse correlation was noted between salt content and total phenolic content. Among the post-desalination processes, desalination with centrifugal dehydration (CD) significantly reduced salt content. CD ethanol extract (CD-E) induced the longest sleep duration in the pentobarbital-induced sleep test in ethanol extracts. Moreover, 1000 mg/kg CD-E had a significant effect on non-rapid eye movement sleep but did not affect delta activity. These findings highlight the potential of industrializing CF as a functional food through desalination and its promise as a natural aid for sleep promotion. [ABSTRACT FROM AUTHOR]

This work focused on the leakage of the composite pressure vessel with a structure consisting of an aluminum alloy inner liner, a composite winding layer, and an aluminum covering. Through applying the finite element simulation approach and leakage rate test, it was found that the average strain of the winding layer in the lap region at the pressure of 46 MPa is 0.0078. Additionally, the leakage rate of the covering adhesive joint was investigated by considering the deformation, revealing that the leakage rate increases with increasing test pressure. The leakage rate at the lap region with a length of 18 mm is 2.05 × 10−7 Pa·m3/s at 0.0078 strain decreasing by 1.46 and 2.31 times compared to those under 12 and 7 mm lengths, respectively. The leakage rate exhibits a strict inverse correlation with the length of the leakage path under a pressure of 0 MPa. Additionally, when the deformation remains below the critical strain threshold (approximately 0.6%), the relationship between pressure and leakage rate shows a linear positive correlation. When the deformation of the component exceeds the critical strain threshold, the leakage rate of the component is significantly affected by its deformation and an increase in overall deformation results in a greater increase in leakage rate. The relationship between the two exhibits a non‐linear trend. This work provides strong technical support for the leakage assessment of composite pressure vessels. Highlights: Deformation of the pressure vessel was analyzed through theoretical and simulation approaches.Establishing the relationship between deformation and pressure in metal–metal lap structures.Leakage analysis for different metal–metal lap lengths and deformation conditions. [ABSTRACT FROM AUTHOR]

The Atlantic Forest Biome (AFB) creates an ideal environment for the proliferation of vector mosquitoes, such as Haemagogus and Sabethes species, which transmit the Yellow Fever virus (YFV) to both human and non-human primates (NHP) (particularly Alouatta sp. and Callithrix sp.). From 2016 to 2020, 748 fatal cases of YF in humans and 1,763 in NHPs were reported in this biome, following several years free from the disease. This underscores the imminent risk posed by the YFV. In this study, we examined the spatiotemporal distribution patterns of YF cases in both NHPs and humans across the entire AFB during the outbreak period, using a generalized linear mixed regression model (GLMM) at the municipal level. Our analysis examined factors associated with the spread of YFV, including environmental characteristics, climate conditions, human vaccination coverage, and the presence of two additional YFV-affected NHP species. The occurrence of epizootics has been directly associated with natural forest formations and the presence of species within the Callithrix genus. Additionally, epizootics have been shown to be directly associated with human prevalence. Furthermore, human prevalence showed an inverse correlation with urban areas, temporary croplands, and savannah and grassland areas. Further analyses using Moran's Index to incorporate the neighborhoods of municipalities with cases in each studied host revealed additional variables, such as altitude, which showed a positive correlation. Additionally, the occurrence of the disease in both hosts exhibited a spatio-temporal distribution pattern. To effectively mitigate the spread of the virus, it is necessary to proactively expand vaccination coverage, refine NHP surveillance strategies, and enhance entomological surveillance in both natural and modified environments. [ABSTRACT FROM AUTHOR]

The addition of Navicula sp. to shrimp nurseries can improve the growth of Penaeus vannamei reared in biofloc systems. However, the contribution of microalgae to the biofloc formation and the effective contribution to shrimp nutrition remain unknown. In this study, Navicula sp. was added to biofloc nursery systems of P. vannamei at distinct time frequencies for evaluating its nutritional contribution to shrimp growth. Nursery rearing was carried out in bioflocs for 35 days at a stocking density of 3000 post-larvae m−3. Shrimp were fed using a commercial feed plus fresh culture of Navicula sp. at different frequencies: no addition of Navicula sp. (WN – control), the addition of 10 × 104 cells mL−1 of the diatom every 5, 10 and 15 days (N5, N10 and N15, respectively). Food sources relative contribution to P. vannamei development was estimated using a Bayesian mixture model. The isotopic discrimination factor (Δ15N and Δ13C) for each food source was determined experimentally. After 35 days of culture, survival (∼93 %) was similar across all treatments but there was a significant difference in weight gain and feed conversion ratio. The N10 treatment (0.50 ± 0.05 g, 0.99 ± 0.01) exhibited better growth parameters when compared to the WN treatment (0.33 ± 0.07 g, 11.46 ± 0.30). Biofloc was the food source most assimilated by shrimp followed by Navicula sp. and commercial feed. Contribution of Navicula sp. was higher in the N5 treatment. In the treatments with diatom addition, an inverse correlation was observed between the relative contributions of biofloc and Navicula sp., indicating that Navicula sp. is not in the biofloc composition, but it is directly consumed by P. vannamei post-larvae. Biofloc and Navicula sp. exhibited larger contributions to the growth of shrimp, reinforcing the importance of natural food sources to the aquaculture of P. vannamei post-larvae. [ABSTRACT FROM AUTHOR]

Introduction: This study investigates the relationship between patient age, gender, and various complications, such as pain, restricted range of motion (ROM), and hemorrhage following total knee arthroplasty. Materials and Methods: This cross-sectional study included 62 patients (Mean±SD age= 65.9±7.38 years; female participants=74.2%) who underwent total knee arthroplasty at Atieh Hospital in Tehran, Iran, between 2020 and 2021. Pain levels were assessed using the numerical pain rating score. Meanwhile, knee joint ROM was evaluated using a reliable mobile application. Hemorrhage was measured through knee joint drainage. Statistical analyses were performed to analyze the data. Results: Women reported higher pain levels and more restricted ROM in passive knee extension and active/passive knee flexion compared to men (P<0.05). However, no significant differences were observed between genders in active knee extension and hemorrhage. A significant inverse correlation was found between pain and ROM in passive knee extension (rho=-0.41, P≤0.001), as well as in active (rho=-0.5, P≤0.001) and passive knee flexion (rho= -0.59, P≤0.001). However, no significant relationship was observed between pain and active knee extension or hemorrhage. Age showed no statistically significant correlation with the other variables. Conclusion: This study highlights the association between higher pain levels and greater ROM restrictions in passive knee extension and active/passive knee flexion following total knee arthroplasty; however, patient age and gender were not found to be associated with postoperative hemorrhage. These findings underscore the importance of closely monitoring pain and ROM, particularly in women undergoing total knee arthroplasty. [ABSTRACT FROM AUTHOR]

Purpose: The aim of the current study was to investigate the mtDNA methylation levels and mtDNA copy numbers in the sperm of patients with asthenozoospermia and compare them to those observed in controls with normozoospermia. Methods: Pyrosequencing analysis of the methylation levels of the mitochondrial D-loop and MT-CO1/chr1:631,907–632083/chrX:26,471,887–126,472,063 (hereinafter referred to as "MT-CO1-AVG") region and quantitative PCR analysis of the mtDNA copy number were performed on sperm from 30 patients with asthenozoospermia and 30 controls with normozoospermia. Results: Compared with those of controls with normozoospermia, the methylation levels of D-loop and MT-CO1-AVG regions and mtDNA copy number were significantly higher in patients with asthenozoospermia. The methylation level of the D-loop region in patients with asthenozoospermia and controls with normozoospermia and that of MT-CO1-AVG region in patients with asthenozoospermia showed a decreasing tendency with increasing total sperm motility. A significant inverse correlation between the mtDNA copy number and total sperm motility was observed in patients with asthenozoospermia but not in controls with normozoospermia. In patients with asthenozoospermia, but not in controls with normozoospermia, we observed a significant inverse correlation between D-loop methylation levels and mtDNA copy number, while no significant correlation was observed between MT-CO1-AVG methylation levels and mtDNA copy number. Conclusion: These results reveal the occurrence of mtDNA methylation in human sperm and altered D-loop and MT-CO1-AVG methylation levels in patients with asthenozoospermia. Additional research is needed to determine the function of these features in the etiology and course of asthenozoospermia. [ABSTRACT FROM AUTHOR]

This study is inspired by an experimental observation for vortex-induced vibrations (VIVs) of a double-hanger cable system, in which a smaller vibration of the downwind hanger cable is re-excited over a narrow range of wind speeds beyond the "lock-in" range. This phenomenon is known as the wake vortex-induced vibrations (WVIVs), where the upstream wake flow induces downstream vibrations. To further investigate the characteristics and reasons for WVIVs, a refined wind tunnel test of double-hanger cable was conducted to consider the influence of aerodynamic interaction. The double-hanger cable was modeled by the tandem-arranged spring-mounted cylinders vibrating in two dimensions. The vibration responses of hanger cables were obtained under various wind speeds to reproduce the lock-in phenomenon. In addition, the vibration trajectory, phase relationship, damping ratio, inter-cable correlation, and the wind pressure on the surface of cables were analyzed. Finally, the Stockbridge dampers were designed to suppress the vibrations. The results show that under the aerodynamic interaction of the cables, the onset wind speed of VIVs in the double cables increases, and the downstream cable WVIVs closely follow the VIVs. During the WVIV phase, the downstream cable behavior is characterized by increased negative aerodynamic damping and an inverse displacement correlation between the cables. The phase relationships between the cables are time-varying due to the aerodynamic interaction. The first proper orthogonal decomposition mode of wind pressure dominates the cross-wind of motions and is crucial in vibrations. Stockbridge dampers can effectively reduce the amplitude of VIVs and eliminate WVIVs in cables. [ABSTRACT FROM AUTHOR]

The formation of large-scale circulating structures (LSC) is one of the critical characteristics of turbulent Rayleigh–Bénard convection (RBC). Although the effect of LSC in turbulent RBC was disputed due to conflicting results, recently, the results of three-dimensional direct numerical simulation [Zwirner et al., "Elliptical instability and multiple-roll flow modes of the large-scale circulation in confined turbulent Rayleigh-Bénard convection," Phys. Rev. Lett. 125, 54502 (2020)] confirmed that in RBC flows with a low Prandtl number, P r = 0.1 within Oberbeck–Boussinesq assumption, the formation of higher number of LSC leads to a decrease in heat and momentum transfer. However, it was shown that for higher Prandtl numbers, heat/momentum transfer is not correlated with the number of LSC. Experimental evidence is investigated of an inverse correlation between the momentum transfer and small-scale rolling structures for high Prandtl non-Oberbeck–Boussinesq condition. Experiments were undertaken at a Prandtl number of P r = 7 and Rayleigh number of R a = 5.3 × 10 7 in a cubical convection cell with an unit aspect ratio. Particle image velocimetry along with a robust combinatorial vortex detection algorithm was used to capture the flow field, detect the rolling structures, and estimate their size. It was found that although the flow structures were dominated by the LSC, the number of smaller rolling structures was significant. The results also showed that after the initiation of convection while the flow was still undeveloped, the majority of rolling structures were small scale. For this state, an inverse correlation between the number of rolling structures and momentum transfer was observed highlighting the influence of flow rolling structures regardless of the formation of the LSC. [ABSTRACT FROM AUTHOR]

Background: Lower urinary tract (LUT) symptoms are reported in more than 80% of patients with multiple sclerosis (MS), most commonly an overactive bladder (OAB). The relationship between brain white matter (WM) changes in MS and OAB symptoms is poorly understood. Objectives: We aim to evaluate (i) microstructural WM differences across MS patients (pwMS) with OAB symptoms, patients without LUT symptoms, and healthy subjects using diffusion tensor imaging (DTI), and (ii) associations between clinical OAB symptom scores and DTI indices. Methods: Twenty-nine female pwMS [mean age (SD) 43.3 years (9.4)], including seventeen with OAB [mean age (SD) 46.1 years (8.6)] and nine without LUT symptoms [mean age (SD) 37.5 years (8.9)], and fourteen healthy controls (HCs) [mean age (SD) 48.5 years (20)] were scanned in a 3T MRI with a DTI protocol. Additionally, clinical scans were performed for WM lesion segmentation. Group differences in fractional anisotropy (FA) were evaluated using tract-based spatial statistics. The Urinary Symptom Profile questionnaire assessed OAB severity. Results: A statistically significant reduction in FA (p = 0.004) was identified in microstructural WM in pwMS, compared with HCs. An inverse correlation was found between FA in frontal and parietal WM lobes and OAB scores (p = 0.021) in pwMS. Areas of lower FA, although this did not reach statistical significance, were found in both frontal lobes and the rest of the non-dominant hemisphere in pwMS with OAB compared with pwMS without LUT symptoms (p = 0.072). Conclusions: This study identified that lesions affecting different WM tracts in MS can result in OAB symptoms and demonstrated the role of the WM in the neural control of LUT functions. By using DTI, the association between OAB symptom severity and WM changes were identified, adding knowledge to the current LUT working model. As MS is predominantly a WM disease, these findings suggest that regional WM involvement, including of the anterior corona radiata, anterior thalamic radiation, superior longitudinal fasciculus, and superior frontal-occipital fasciculus and a non-dominant prevalence in WM, can result in OAB symptoms. OAB symptoms in MS correlate with anisotropy changes in different white matter tracts as demonstrated by DTI. Structural impairment in WM tracts plays an important role in LUT symptoms in MS. [ABSTRACT FROM AUTHOR]

Polar mesospheric clouds (PMCs) are ice crystal clouds formed in the mesosphere of high-latitude regions in both the northern (NH) and southern hemispheres (SH). Peak height is an important physical characteristic of PMCs. Satellite observation data from solar occultation for ice experiments (SOFIE) during seven PMC seasons from 2007 to 2014 show that the difference between the height of the mesopause and the peak height of the PMCs (Zmes-Zmax) were inversely correlated with the atmospheric mesopause temperature. The Zmes-Zmax averages for all seasons for the NH and SH were 3.54 km and 2.66 km, respectively. They were smaller at the starting and ending stages of each PMC season and larger in the middle stages. Analysis of the individual cases and statistical results simulated by the PMCs 0-D model also revealed the inverse correlations between the Zmes-Zmax and mesopause temperature, with correlation coefficients of −0.71 and −0.62 for the NH and SH, respectively. The corresponding rates of change of Zmes-Zmax with respect to mesopause temperature were found to be −0.21 km/K and −0.14 km/K, respectively. The formation mechanism of PMCs suggests that a lower temperature around the mesopause can lead to a greater distance and longer time for ice crystals to condense and grow in clouds. Thus, ice crystals sediment to a lower height, making the peak height of the PMCs further away from the mesopause. In addition, disturbances in small-scale dynamic processes tend to weaken the impact of temperature on the peak height of PMCs. [ABSTRACT FROM AUTHOR]

This study investigates the insecticidal efficacy of low doses of Beauveria bassiana and Bacillus thuringiensis on second and fourth instar Helicoverpa armigera larvae, encompassing various facets of toxicity, developmental impacts, diet consumption, frass production, weight gain, and foliar persistence. Bt and Bb were evaluated for insecticidal properties against the 2nd and 4th instar of H. armigera. To each larvae, a Bt-treated diet (1 ml) was provided to feed for 72 h. For the application of Bb, larvae were dipped in spore suspension (1 × 106 and 1 × 107 conidia ml−1) for 10 s. For combined application of Bb and Bt, larvae were first dipped in fungal suspension and then allowed to feed on Bt-treated diet in rearing vials (7 × 3 cm). The research reveals concentration-dependent responses, wherein increased mortality, reduced pupation, adult emergence, and egg hatching are observed. Notably, second instar larvae exhibit higher susceptibility, demonstrating a linear correlation between mortality and developmental stage. A synergistic effect (Co-toxicity Factor CTF ≥ 20) is observed when larvae are simultaneously exposed to higher concentrations of B. bassiana (1 × 107 conidia ml−1) and B. thuringiensis isolates (Bt-a1 and Bt-s1), both for second and fourth instar H. armigera larvae. Lower concentrations of B. bassiana (1 × 10−6 conidia ml−1) yield an additive effect in combination with Bt. Pupation, adult emergence, and egg eclosion from surviving individuals show an inverse correlation with the toxic level of microbial agents. Growth and development are adversely affected when treated with B. bassiana and fed on B. thuringiensis-mixed diets, resulting in significant variations in larval and pupal duration, pupal weight, and adult longevity. The study results highlight an increase in larval and pupal duration, alongside a decrease in pupal weight and adult longevity, corresponding to the lethal action of the applied agents. Additionally, microbial agents impact weight gain, frass production, and diet consumption. Larvae treated with lower concentrations of B. bassiana (1 × 106 conidia ml−1) and B. thuringiensis demonstrate higher weight gain compared to higher application rates (1 × 107 conidia ml−1) or combined applications. The initial weight of larvae influences weight gain and diet consumption, aligning with the pathogenicity of the applied agents. In conclusion, this study underscores the substantial influence of microbial agents on the growth, development, diet intake, and frass production of H. armigera. Leveraging the susceptibility of H. armigera larvae to B. bassiana and B. thuringiensis presents an effective strategy to mitigate feeding and survival under field conditions. [ABSTRACT FROM AUTHOR]

Observations and model studies suggest that front dynamics can enhance phytoplankton productivity. This study tested whether frontal systems also increase the abundance of nitrifying microbes and nitrogen recycling during repeat sampling transects across the Mid‐Atlantic Bight shelfbreak in July 2019. We measured ammonium concentrations, nitrate dual isotopes (δ15N, δ18O), and ammonia monooxygenase subunit A (amoA) genes of ammonia‐oxidizing archaea (AOA) and bacteria (AOB). In subsurface shelf waters, ammonium concentrations exceeded 2 μmol L−1, due to a temporary imbalance in regeneration from sinking particles and subsequent nitrification. The inverse correlation between nitrate δ15N values and ammonium concentrations confirmed nitrate was partially or entirely from local nitrification on the shelf. In contrast, the shelfbreak frontal zone and slope sea subsurface waters had much lower ammonium concentrations (0.1–0.2 μmol L−1) due to tight coupling between ammonium regeneration and nitrification. The deviation of nitrate δ15N and δ18O from algal uptake‐driven 1 : 1 ratio suggests concurrent nitrification in the euphotic zone. The shelfbreak front acted as an ecological boundary where AOA and AOB amoA gene numbers were partitioned, with AOAs abounding in slope waters and AOBs in shelf waters, likely due to ammonium availability. At certain slope stations, deep‐water nutrient inputs via isopycnal lifting induced by Gulf Stream intrusions caused unexpectedly high phytoplankton biomass, which doubled nitrifier abundance and potentially stimulated both ammonium regeneration and nitrification. These findings demonstrate distinct distributions of nitrifying microbes along the salinity gradient from shelf to slope and highlight the significant influence of coastal ocean‐western boundary current interactions on nitrogen biogeochemistry. [ABSTRACT FROM AUTHOR]

This study investigates the relationship between sea surface temperature (SST) anomalies in the subtropical Atlantic Ocean, as represented by the Southern Atlantic subtropical dipole (SASD), and SST anomalies in the tropical Pacific Ocean, identified by the El Niño‐Southern Oscillation (ENSO). Contrary to the previously held notion of a weak relationship between SASD and ENSO as suggested by earlier literature, our analysis reveals a substantial inverse correlation between the two. This correlation exhibits significant multi‐decadal variability, which has notably intensified over the most recent two decades compared with the preceding two decades. This intensification in the SASD–ENSO inverse correlation may be attributed to the shift in ENSO regime from predominance of eastern Pacific El Niño to central Pacific El Niño events around the turn of the century. This transition triggers wavetrains that propagate along different paths, consequently influencing the South Atlantic subtropical high and inducing alterations in anomalous SST patterns in the subtropical Atlantic Ocean. These findings advance our comprehension of the interactions between South Atlantic and Pacific SST variations, which strongly influence rainfall patterns, particularly in South America and southern Africa. Understanding such teleconnection holds promise for improving sub‐seasonal to seasonal precipitation predictions in these regions. [ABSTRACT FROM AUTHOR]

Aims/Introduction: Blood glucose meters are commonly used at the bedside, but most of the meters used in Hung Vuong Hospital (Ho Chi Minh City, Vietnam) are built for self‐monitoring and might not be suitable for determining glucose levels in patients. In this study, we aimed to validate the performance of six frequently used meters in our hospital using the Clinical & Laboratory Standards Institute (CLSI) standard, and investigate the hematocrit impact on the accuracy of these meters. Materials and Methods: A total of 135 pregnant women who underwent a 75‐g oral glucose tolerance test consented to participate in the study at Hung Vuong Hospital. Whole blood glucose levels were measured in duplicate using meters, and hematocrit levels were measured using an Alinity h‐series analyzer. Within 5 min, plasma glucose levels were measured twice in a row using the Cobas c502 reference analyzer. For accuracy and precision, the hematocrit effect was assed using CLSI POCT12‐A3. Results: Out of six evaluated meters, three meters qualified. For CLSI criterion at glucose concentration of 5.55 mmol/L, Accu‐Chek Inform II, Accu‐Chek Performa and OneTouch VerioVue achieved 97.31%, 98.08% and 99.62%, respectively. For CLSI criterion at 4.17 mmol/L, these three achieved 100%. Accu‐Chek Inform II and Accu‐Chek Performa showed an inverse correlation between glucose level and hematocrit with slopes of −0.500 (95% confidence interval −0.678 to −0.322) and −0.396 (95% confidence interval −0.569 to −0.224), whereas OneTouch VerioVue was not affected by hematocrit, with a slope of 0.207 (95% confidence interval −0.026 to 0.440). Conclusions: Blood glucose meters' measurements can be affected by hematocrit, and might provide readings not within an acceptable bias. Medical organizations need to verify or validate before using on patients. [ABSTRACT FROM AUTHOR]

Purpose Methods Results Conclusions To determine how corneoscleral geometry changes with axial length and to assess the usefulness of including the sagittal configuration of the anterior segment when predicting the axial length.An observational study was performed including 96 healthy subjects (96 eyes). Axial length was calculated from optical biometry (IOL Master 500). Corneal curvature and scleral sagittal height parameters at 13, 14 and 15 mm were obtained automatically using corneoscleral topography (eye surface profiler; ESP). In addition, corneal and scleral sagittal heights at numerous locations (21 radii: 0–10 mm from the corneal apex at 12 angles: 0–330°) were calculated using the raw height data extracted from the ESP. The relationships between axial length and the study parameters were analysed using Pearson correlation analysis. The equations for the prediction of axial length were obtained by fitting multiple linear regression models.The temporal‐nasal scleral asymmetry at 13‐, 14‐ and 15‐mm chord lengths was significantly correlated with axial length (r2 ≤ 0.26; p < 0.001). Significant inverse correlations were found between the temporal scleral sagittal height and axial length (r2 ≤ 0.28; p ≤ 0.02). The nasal scleral sagittal height was not associated with axial length. Three significant multiple linear regression models were fitted based on spherical equivalent, corneal radius and scleral asymmetry at 13 (r2 = 0.79; p < 0.001), 14 (r2 = 0.80; p < 0.001) and 15 (r2 = 0.80; p < 0.001) mm chord lengths.Larger ocular globes show reduced temporal‐nasal scleral asymmetry, mainly due to the lower sagittal height of the temporal sclera. Thus, the geometry of the temporal scleral may be a factor of interest during myopia progression. [ABSTRACT FROM AUTHOR]

Highlights In this study, we present a model for predicting the Young's modulus of polymer/nanodiamond (ND) composites, taking into account the interphase properties. The Christensen‐Lo model is adapted and refined to predict the modulus of ND‐based nanocomposites by considering the properties of spherical NDs and their surrounding interphase. The outcomes of the developed model are benchmarked against experimental data, exploring the impact of various parameters, such as ND radius, ND concentration, and interphase properties (thickness and modulus) on the nanocomposite modulus. Findings suggest an inverse correlation between the size of the nanoparticles and the modulus of nanocomposite. Specifically, it is observed that nanoparticles with a minimum radius of 1 nm and a maximum concentration of 5 vol% can increase the nanocomposite modulus by 180%. Additionally, maximum thickness and modulus of the interphase can significantly improve the nanocomposite modulus. The highest interphase thickness of 10 nm and maximum interphase modulus of 100 GPa can grow the modulus of samples by 300%. The predicted influences of all parameters on the nanocomposite modulus validate the accuracy of the developed model. A model for the Young's modulus of polymer nanodiamond (ND) composites is presented. ND radius, ND concentration, and interphase thickness and modulus are considered. The outcomes of the developed model are compared to the experimental data. 5 vol% of the smallest ND (R = 1 nm) increases the nanocomposite modulus by 180%. The thickest and the toughest interphase enhance the nanocomposite modulus by 300%. [ABSTRACT FROM AUTHOR]

TikTok, with its visual content and setup, has emerged as a powerful platform for fast fashion. This study examines how Zara uses TikTok to communicate with consumers, promote products and strengthen its brand. Content strategies, interaction with users and the impact on brand perception were analysed. Collaborations with content creators and special launches were found to broaden the audience and generate greater engagement. Video length also influences success, with an inverse correlation between length and likes. This analysis provides insights to understand and optimize brands' presence on TikTok. [ABSTRACT FROM AUTHOR]

Both composition and temperature play a crucial role in determining the NO radiative cooling in lower thermosphere as observed by TIMED/SABER. In this work, we present a detailed investigation of seasonal variation in thermospheric NO radiative cooling. We have carried forward the investigation of Li et al. (2018) regarding the variations in local nighttime peak NO radiative cooling and its altitude during solar maximum and solar minimum conditions. By analyzing latitudinal changes over quiet times for each month in year 2018, it is evident that both the investigated parameters exhibit summer-winter variability. The qualitative contribution of different species (i.e., NO, and O), and temperatures in determining the vertical profile of NO radiative cooling for different latitudes is investigated by utilizing the NRLMSISE-00 estimated parameters, and SNOE observed NO density. The temperature, NO density, and compositional variations due to asymmetrical solar heating and associated summer-to-winter circulation in both the hemispheres during solar minimum conditions seem to be the dominating factor in controlling the NO radiative cooling during different seasons. The altitudes at which maximum cooling by NO occurs exhibits an inverse correlation with the amount of radiative cooling. The region of enhanced NO densities (polar and summer hemispheric low-mid latitude regions) have larger NO radiative cooling with lower peak altitudes in comparison to other regions (equatorial to winter hemispheric low-mid latitude regions), where NO radiative cooling is low with higher peak altitude values. [ABSTRACT FROM AUTHOR]

In this research paper analysis of the dynamics of the moisture content of the soil layer of chernozem and the accumulation of productive moisture reserves in its thickness was carried out, based on a set of data from 1947 to 2022. The change in the moisture regime within the periodically leaching water regime of the central part of the Left Bank Forest- Steppe of Ukraine has been analyzed. The analysis was performed under the crops: winter wheat, spring barley, corn for grain and silage, sugar beet, sunflower in crop rotations of various types to a depth of 0-100 cm to 0-300 cm. The purpose of the research was to establish the features of the formation of reserves of productive moisture in the chernozem thickness in a seasonal dimension upon the dynamics of climatic parameters against the background of their intracentury climatic variability for the conditions of the left bank part of the central Forest-Steppe of Ukraine. The generally accepted research methods were used: field, laboratory, mathematical, statistical and comparative calculation. Based on the conducted research, the following results were obtained. In order to form a non-flushing humidification regime, it is necessary to accumulate 117-135 mm in the thickness of 0-100 cm, which will correspond to a reserve in the thickness of 0-200 cm - 117-167 mm. For periodic flushing water regime 160-165 mm of moisture should be accumulated in the 0-100 cm thickness, which will provide a moisture reserve of 300 mm in the 0-200 cm thickness. The flushing water regime is formed with a moisture reserve in the thickness of 0-100 cm in the amount of 175 mm, which provides a moisture reserve in the thicknesses of 0-150 cm and 0-200 cm - 250 mm and 315 mm, which corresponds to the reserve of NV-VRK, and the thickness of 0-300 cm is saturated with moisture in an amount of more than 400 mm (HB-VK). Calculation of the paired correlation coefficients showed that an inverse strong correlation (R > -0.70) was found between the amount of precipitation for November - March and the supply of moisture to the meter layer of soil (R > -0.70), and the consumption of moisture from the soil for April - July correlated with the precipitation for November - March at the level of direct strong correlation (R ≥ 0.70). The relationship with the moisture consumption from the moisture potential for April - August was at the level of an inverse strong correlation (R < 0.70), i.e. the higher the amount of precipitation during the autumn-winter-spring period (cold period), the less moisture is recorded in a meter-thick layer, the greater its consumption in April-July from the soil and the smaller consumption of moisture potential in April-August. The zone of the central Forest-Steppe is characterized by a periodically leaching water regime, when an average of 165 mm of moisture accumulates in a meter-thick chernozem, and therefore gravitates towards the values of the moisture reserve in the non-flushing water regime, which exceeds its value by 25 mm, which is a stable trend of aridization of soil conditions in spring period. The conditions of moistening chernozems, formed in a long-term time interval under the present climatic conditions of the central part of the Left Bank Forest- Steppe, cannot be shifted under the influence of agrotechnical influences beyond the parameters of the non-leaching or periodically leaching water conditions in the agrocenosis. There is manifested the process of the self-regulation stability of the Forest-Steppe zone against active aridization and the "attack" of the Steppe on the Forest-Steppe. [ABSTRACT FROM AUTHOR]

Background: Polycystic ovarian syndrome is affecting around 5-15% of females. Spexin hormone, identified as neuropeptide Q, has been newly recognized by bioinformatics methods. Objective: To evaluate the relationship concerning levels of spexin hormone with metabolic disruption in women with polycystic ovarian syndrome. Patients and Methods: A case-control study carried out in the department of Obstetrics and Gynecology in Al-Imamain Al-Khademain medical city/Baghdad, Iraq, from Jan 1, 2022, to the end of Dec 31, 2022. The study sample comprises, 192 participants aged 18-45 years were joined and allocated into a case group (96 women with PCOS) and a control group (96 women without PCOS). Results: Mean value of spexin hormone was (2.7±0.3 ng/mL) in the PCOS group, while it was (3.5±0.7 ng/mL) in the control group; fasting blood sugar shows significant association with a negative, weak correlation with Spexin in patients (P-value= 0.005), Insulin shows significant association with inverse correlation with Spexin in patients (P-value= 0.04), Homeostasis model valuation of insulin resistance (HOMA-IR) shows significant association with inverse correlation with Spexin in patients (P-value= 0.003). Spexin had a significant inverse correlation with LH, SHBG, testosterone, FAI, and Dehydroepiandrosterone. Conclusion: Serum level of spexin hormone was meaningfully decreased in patients with PCOS than that in healthy women. [ABSTRACT FROM AUTHOR]

This study explores the efficiency and applicability of a HONO collection system that incorporates an ultrasonic nozzle and spray chamber for the measurement of ambient air. The system demonstrates (1) a remarkable efficiency of 97.7% across two serial stages, (2) lower detection limits of 0.15 ppbv for HONO, and (3) an absence of interference from NO2 or OH radicals. Practical ambient monitoring with the HONO collection system revealed typical diurnal variations in HONO, O3, and HNO3 concentrations, aligning with photolysis dynamics. Notably, HONO concentrations peaked at 0.37 ppb during nighttime and decreased to 0.27 ppb by midday. O3 demonstrated an inverse relationship with HONO, especially during ozone depletion phases, with r2 values of 0.94, 0.81, and 0.52 across various intervals. The HONO/NOx ratio during periods of enhanced HONO suggested the presence of additional formation mechanisms beyond heterogeneous NOx reactions. Moreover, ozone levels often fell below 20 ppb, indicating a consistent inverse correlation with HONO, thereby reaffirming further mechanisms of HONO formation beyond heterogeneous NOx reactions. The real-time atmospheric chemical reactions involving HONO, monitored concurrently with O3 and NOx, were effectively validated by the HONO collection system employed in this investigation. [ABSTRACT FROM AUTHOR]

It has been demonstrated previously that human leukocyte antigen class I (HLA-I) and class II (HLA-II) alleles may modulate JAK2 V617F and CALR mutation (CALRmut)-associated oncogenesis in myeloproliferative neoplasms (MPNs). However, the role of immunogenetic factors in MPNs remains underexplored. We aimed to investigate the potential involvement of HLA genes in CALRmut+ MPNs. High-resolution genotyping of HLA-I and -II loci was conducted in 42 CALRmut+ and 158 JAK2 V617F+ MPN patients and 1,083 healthy controls. A global analysis of the diversity of HLA-I genotypes revealed no significant differences between CALRmut+ patients and controls. However, one HLA-I allele (C*06:02) showed an inverse correlation with presence of CALR mutation. A meta-analysis across independent cohorts and healthy individuals from the 1000 Genomes Project confirmed an inverse correlation between the presentation capabilities of the HLA-I loci for JAK2 V617F and CALRmut-derived peptides in both patients and healthy individuals. scRNA-Seq analysis revealed low expression of TAP1 and CIITA genes in CALRmut+ hematopoietic stem and progenitor cells. In conclusion, the HLA-I genotype differentially restricts JAK2 V617F and CALRmut-driven oncogenesis potentially explaining the mutual exclusivity of the two mutations and differences in their presentation latency. These findings have practical implications for the development of neoantigen-based vaccines in MPNs. [ABSTRACT FROM AUTHOR]

This study aimed to assess clinical and radiographic outcomes, including implant survival, marginal bone loss, and patient satisfaction, in individuals with severe bone atrophy treated using a newly developed system of short and extra-short implants. A total of 44 implants (37 short and 7 extra-short) were placed with immediate loading in 11 patients. The patients were followed up at between 6 and 24 months. Bone changes, keratinized mucosa, bleeding on probing, probing depth, crown-to-implant ratio, and patient satisfaction were evaluated. An implant survival and success rate of 100% was observed. The peri-implant bone condition showed no significant associations between marginal bone loss (MBL) and gingival recession. In extra-short implants, the crown-to-implant ratio did not affect MBL in the evaluated times. However, short implants showed a statistically significant inverse correlation between mesial measurement and crown-to-implant ratio (p = 0.006) and between distal measurement and crown-to-implant ratio (p = 0.004) over six months. Plaque was present in the mesiobuccal regions in 38.64% of the implants, with extra-short implants having the highest relative frequency (71.4%). Bleeding was observed in 18.9% of the short implants in the mesiolingual region and 14.3% of the extra-short implants. There was a statistically significant association between bleeding on probing in the mesiobuccal region and the type of implant (p = 0.026). The analysis of probing depth showed no difference between the types of implants. Within the limits of this study, short and extra-short implants presented similar clinical and radiographic behavior of soft and hard tissues in the evaluated times. [ABSTRACT FROM AUTHOR]

Background: Vitamin D is a fat-soluble vitamin found in two forms, sourced either from plants (D2) or animals (D3). Numerous epidemiological studies worldwide have highlighted its deficiency across diverse populations in various countries. When coupled with obesity, this deficiency becomes a significant global health concern. Our study aimed to evaluate the vitamin D levels among obese individuals in Southern Morocco. Methods: This is a retrospective, cross-sectional descriptive study on the vitamin D status in obese subjects. This study was conducted at the "Health Universe" Diet Center in Agadir, Morocco. The measurement method involved using a Tanita® wall-mounted metal stadiometer to determine height and a Tanita® BC 418 MA segmental body composition analyzer to determine weight. The serum level of 25-hydroxyvitamin D was determined by electrochemiluminescence (ECLIA) using the Elecsys® and Cobas e411®. Results: The sample of our study, consisting of 1,210 individuals, is composed of 73.5% (n = 889) females and 26.5% (n = 321) males. The mean age of the entire sample is 42.3 ± 13.1 years (ranging from 18 to 86 years). The mean BMI is 37 ± 5.69 kg/m², with a higher value in females (37.4 ± 5.85 kg/m²) compared to males (35.7 ± 5.03 kg/m²), including 42.8% moderate obesity, 34.2% severe obesity, and 23% morbid obesity. The mean serum vitamin D level in our sample is 15.7 ± 7.67 ng/mL. This level is 14.5 ± 7.42 ng/mL for females and 19.2 ± 7.31 ng/mL for males. However, only 5.3% of the subjects have an adequate serum vitamin D level, while 18% have an insufficiency, 52.5% have a moderate deficiency, and 24.2% have a severe deficiency. An inverse trend was noted for BMI, which shows a very significant inverse correlation with serum vitamin D concentration (r = -0.18 and p < 0.01). Conclusions: Our results support the hypothesis that obesity is inversely associated with low vitamin D levels. Lifestyle improvement should be considered as the primary treatment option, aiming to enhance the dysmetabolic state associated with obesity and vitamin D deficiency. [ABSTRACT FROM AUTHOR]

Introduction Methods Results Conclusion Obesity is implicated in adverse atrial remodeling and worse outcomes in patients with atrial fibrillation. The objective of this study is to assess the effect of body mass index (BMI) on ablation‐induced scar formation on late gadolinium enhancement cardiac magnetic resonance imaging (LGE‐CMR).We conducted an analysis of DECAAF II participants who underwent LGE‐CMR scans to measure scar formation 3 months after catheter ablation. Ablation parameters and lesion delivery were not dependent on BMI. The effect of BMI on ablation success was explored.Our analyses included 811 patients. Comorbidities were more prevalent in obese patients. Baseline left atrial volume was higher in obese individuals, 118, 126, 135, 140, and 143 mm3 for normal weight, overweight, obese grade 1, 2, and 3, respectively (p < .001). BMI was associated with scar formation (R = −0.135, p < .001), with patients with Class 3 obesity having the lowest percentage of ablation‐induced scar, 11.1%, 10.3%, 9.5%, 8.8%, 6.8% by ascending BMI group. There was an inverse correlation between BMI and the amount of fibrosis covered by ablation scar, 24%, 23%, 21%, and 18% by ascending BMI group (p = .001). For the fibrosis‐guided ablation group, BMI was associated with residual fibrosis (R = 0.056, p = .005).Obese patients have lower ablation scar formation, covered fibrosis, and more residual fibrosis postablation compared to nonobese patients, regardless of ablation parameters including impedance drop. [ABSTRACT FROM AUTHOR]

Background: The interplay between metabolic disorders and chronic kidney disease (CKD) has been well-documented. However, the connection between CKD and atherogenic index of plasma (AIP) remains understudied. This research delves into the correlation between these two factors, aiming to shed new light on their potential association. Methods: The relationship between AIP and CKD was evaluated using a weighted multivariate logistic regression model, and the curvilinear relationship between AIP and CKD was explored through smooth curve fitting. We engaged a recursive partitioning algorithm in conjunction with a two-stage linear regression model to precisely determine the inflection point. By conducting stratified analyses, the heterogeneity within subpopulations was explored. Results: In the regression model that accounted for all covariates, ORs (95% CI) for the association between CKD and AIP were 1.12 (0.91, 1.36), indicating no significant association between AIP and CKD. However, sensitivity analyses suggested that the relationship between them may be non-linear. Smooth curve analysis confirmed the non-linear relationship between AIP and CKD, identifying an inflection point at -0.55. Below this threshold, AIP exhibited a significant inverse correlation with CKD. Conversely, above this threshold, a pronounced positive correlation was detected. Stratified analyses elucidated that a non-linear association between AIP and CKD was observed among female participants and those aged 50 and above. Conclusion: We found a curvilinear relationship between chronic kidney disease and atherogenic index of plasma. [ABSTRACT FROM AUTHOR]

Background: With the fast-paced advancements of robot technology, human–robot interaction (HRI) has become increasingly popular and complex, and self-efficacy in HRI has received extensive attention. Despite its popularity, this topic remains understudied in China. Objective: In order to provide a psychometrically sound instrument in China, this study aimed to translate and validate the Self-Efficacy in Human–Robot Interaction Scale (SE-HRI) in two Chinese adult samples (N1 = 300, N2 = 500). Methods: The data was analyzed by SPSS 26.0 and Amos 24.0. Item analysis and exploratory factor analysis were conducted using Sample 1 data. Confirmatory factor analysis, criterion-related validity analysis, and reliability analysis were then performed using Sample 2 data. Results: The results revealed that the Chinese SE-HRI scale consisted of 13 items in a two-factor model, suggesting a good model fit. Moreover, general self-efficacy and willingness to accept the use of artificial intelligence (AI) were both positively correlated with self-efficacy in HRI, while negative attitudes toward robots showed an inverse correlation, proving the Chinese SE-HRI scale exhibited excellent criterion-related validity. Conclusion: The Chinese SE-HRI scale is a reliable assessment tool for evaluating self-efficacy in HRI in China. The study discussed implications and limitations, and suggested future directions. [ABSTRACT FROM AUTHOR]

Background: Osteosarcoma (OSC) is considered one of the most common malignant bone tumours in adolescents. Due to OSC's poor prognosis, a comprehensive approach to exploring these aspects is highly needed to improve the survival probability of OSC. In this study, we tried to explore the significance of miRNA-encoded PTEN for clinical-pathological features and prognostic value in OSC. Method: We performed this systematic review and meta-analysis using articles and sources published between 2013 and 2023 from six databases (Scopus, PubMed, ProQuest, Science Direct, Sage Pub, and Cochrane). Included studies were clinical cross-sectional studies. Other study designs, articles not written in English, without full text, and not relevant—were excluded. Then, ROBINS-I is used to evaluate the distance. The results are constructed according to the PICOS criteria in a table. The expression of miRNA related to OSC is assessed in the meta-analysis as the main outcome to determine its ability as a diagnostic and prognostic agent for OSC. This systematic review followed the PRISMA guidelines. Results: A total of 17 studies were included in the final screening. The meta-analysis showed significantly increased (p < 0.00001) miRNA expression in patients with OSC compared to healthy controlled with pooled md (2.85) (95% CI: 2.69, 3.02; I2 = 22%, p = 0.20), the high inverse correlation (p < 0.001) between miRNA and PTEN expression was shown as mean effect size (-0.681) (95% CI: -0.787, -0.536; I2 = 75%, p < 0.0001), and the prognostic evaluation of OS was significantly increased in low expression miRNA (p < 0.00001) with pooled OR. Conclusion: Fifteen miRNAs from 17 studies were found, and together with PTEN expression, they may serve as potential prognostic biomarkers for OSC. High-level levels of miRNA expression are correlated with low PTEN expression, leading to a bad prognosis for OSC. [ABSTRACT FROM AUTHOR]

Schistosomiasis, a parasitic disease caused by Schistosoma spp., affects more than 250 million people worldwide. S. mansoni in particular affects the gastrointestinal tract and, through its eggs, induces a Th2 immune response leading to granuloma formation. The relationship between egg load and immune response is poorly understood. We investigated whether the quantity of parasitic eggs influences the immune response in S. mansoni-infected hamsters. The hepatic and intestinal egg load was assessed, and cytokine expression as well as the expression of three major egg-derived proteins were analyzed in monosex- and bisex-infected animals by qRT-PCR. Statistical correlations between egg load or egg-derived factors Ipse/alpha-1, kappa-5, and omega-1, and the immune response were analyzed in liver and colon tissue. Surprisingly, no correlation of the Th1 cytokines with the hepatic egg load was observed, while the Th2 cytokines Il4, Il5, and Il13 showed an inverse correlation in the liver but not in the colon. A longer embryogenesis of the parasitic eggs in the liver could explain this correlation. This conclusion is supported by the lack of any correlation with immune response in the colon, as the intestinal passage of the eggs is limited to a few days. [ABSTRACT FROM AUTHOR]

In recent years, there has been a notable increase in bullying rates in school. Bullying is characterized as a repeated set of malicious actions by an individual or group toward another individual in an imbalanced power dynamic, resulting in physical, psychological, social, or material harm to the victim, with the intention of causing social exclusion. The scientific literature has investigated the factors that influence this type of behavior, environmental factors, such as school location and student age, as well as other factors, such as gender and level of physical fitness, also play an important role. This study examined the correlation between motor self-efficacy and bullying, considering that physical activity acts as a regulator in these cases. The Kolmogorov-Smirnov test was employed to assess the normality of the data distribution, and Spearman's Rho test was used to analyze the relationship between each dimension of the EBIPQ and E-AEM scores. The Cronbach's alpha was used to evaluate the reliability of each instrument. The results indicated a significant inverse correlation between the EBIP-Q and E-AEM in the variables of sex, educational stage and school environment. In conclusion, an inverse correlation was observed betweenmotor self-efficacy and bullying, indicating that higher levels of motor self-efficacy are related to lower levels of bullying victimization. Motor self-efficacy could be used as a tool to reduce bullying situations at school. It would be important for government policies to encourage the practice of physical activity in all areas of life in order to improve motor self-efficacy and end bullying. [ABSTRACT FROM AUTHOR]

Hydrophobic deep eutectic solvents (HDESs) are a new generation of water-immiscible solvents that have shown potential as green and sustainable reaction media for biocatalytic applications. In this study, esterification of tyrosol and hydroxytyrosol catalysed by Novozym 435 (Candida antarctica lipase B immobilised on acrylic resin) was taken as a model reaction to examine the feasibility of using HDESs as solvents for acylation reactions and the impacts of the components and physicochemical properties of the HDESs on the enzymatic performance. 21 HDESs were screened. Yields as high as 95.1% could be achieved within 2 h of reaction in an HDES, comparable to or even better than the results obtained in organic solvents. The enzymatic reactions were favoured in the HDES comprising a tertiary alcohol instead of a secondary/ primary one as the hydrogen bond acceptor (HBA). Inverse correlations were found between enzyme activity and the polarity and viscosity of the HDES. Carboxylic acid-based eutectic solvents can play a dual role as both a reaction medium and a substrate reservoir for the acylation reaction. These findings provide valuable guidelines for selecting HDESs for biocatalytic applications. [ABSTRACT FROM AUTHOR]

A long‐held tenet in computer science asserts that the training of deep learning is analogous to an alchemical furnace, and its "black box" signature brings forth inexplicability. For electromagnetic metasurfaces, the related intelligent applications also get stuck into such a dilemma. Although the past 5 years have witnessed a proliferation of deep learning‐based works across complex photonic scenarios, they neglect the already existing but untapped physical laws. Here, the intrinsic correlation between the real and imaginary parts of the spectra are revealed using Kramers–Kronig relations, which is then mimicked by bidirectional information flow in neural network space. Such consideration harnesses the missing spectral connection to extract crucial features effectively. The bidirectional recurrent neural network is benchmarked in metasurface inverse design and compare it with a fully‐connected neural network, unidirectional recurrent neural network, and attention‐based transformer. Beyond the improved accuracy, the study examines the intermediate information products and physically explains why different network structures yield different performances. The work offers explicable perspectives to utilize physical information in the deep learning field and facilitates many data‐intensive research endeavors. [ABSTRACT FROM AUTHOR]

Two sets of motor proteins underpin motile cilia/flagella function. The axoneme-associated inner and outer dynein arms drive sliding of adjacent axoneme microtubule doublets to periodically bend the flagellum for beating, while intraflagellar transport (IFT) kinesins and dyneins carry IFT trains bidirectionally along the axoneme. Despite assembling motile cilia and flagella, IFT train speeds have only previously been quantified in immobilized flagella-mechanical immobilization or genetic paralysis. This has limited investigation of the interaction between IFT and flagellar beating. Here, in uniflagellate Leishmania parasites, we use high-frequency, dual-color fluorescence microscopy to visualize IFT train movement in beating flagella. We discovered that adhesion of flagella to a microscope slide is detrimental, reducing IFT train speed and increasing train stalling. In flagella free to move, IFT train speed is not strongly dependent on flagella beat type; however, permanent disruption of flagella beating by deletion of genes necessary for formation or regulation of beating showed an inverse correlation of beat frequency and IFT train speed. [ABSTRACT FROM AUTHOR]

Advancements in veterinary medicine have resulted in increased life spans for dogs, necessitating a better understanding of quality of life for older dogs. This study aimed to evaluate quality of life (QoL) progression and its potential association with mortality in senior and geriatric dogs. The Canine Owner-Reported Quality of Life Questionnaire (CORQ), consisting of 17 questions across four domains (vitality, companionship, pain, and mobility) was employed. Higher scores indicated better quality of life, with 7 as the highest potential score for each question. In a cross-sectional analysis including 92 dogs, we found an inverse correlation between overall CORQ (and all domain scores) and fractional lifespan. The domain of vitality demonstrated the lowest scores, while companionship exhibited the highest. A longitudinal analysis, including 34 dogs, revealed that when dogs reach the geriatric stage (100% of their calculated lifespan), their expected overall CORQ is 5.95 out of 7, and dogs are expected to have a monthly decline of 0.05 units in the score. Cox proportional hazard analysis demonstrated a significant association between overall CORQ scores and mortality, with dogs scoring below 5.35 being at a higher risk of mortality. This study underscores the association between aging, declining quality of life, and increased mortality risk in aging dogs. [ABSTRACT FROM AUTHOR]

Objectives: To assess the predictive value of serum trypsin and trypsinogen activation peptide (TAP) for the severity of AP through a single center cohort study as well as a systematic review of the current literature. Methods: A literature search was conducted using Medline (PubMed), EMBASE and the Cochrane Central Register. A total of 142 patients with acute pancreatitis (AP) were included in the cohort study and parameters of the revised Atlanta criteria of 2012 and the APACHE II were assessed. Results: The review showed promising results for the predictive value of serum trypsinogen-2 but conflicting results for serum TAP and trypsin. In the cohort study, patients were observed for 4 days after diagnosis of AP; 9 patients had severe AP, 35 patients had moderate AP and 81 patients had mild AP. The ratio of the geometric mean of severe vs. mild AP for trypsin was 0.72 (95% CI: 0.51–1.00), p = 0.053 and, for TAP, 0.74 (95% CI: 0.54–1.01), p = 0.055, respectively. Conclusions: The cohort study showed an inverse correlation of serum levels of TAP and trypsin with severity of AP. Serum TAP and trypsin have an inferior predictive value of severity of AP compared to the clinical APACHE II score. [ABSTRACT FROM AUTHOR]

Background: Hepatocellular carcinoma (HCC) is a primary malignant liver tumor characterized by a low survival rate and high mortality. This study aimed to investigate the causal effect of immune cell phenotypes, plasma metabolites, and HCC in East Asian populations. Methods: The summary results for 731 immunocytes, 1400 plasma metabolites, and HCCs were acquired from publicly available genome-wide association studies (GWASs). This study utilized two-sample Mendelian randomization (MR) analysis to establish causal relationships, which was achieved by employing various statistical methods including inverse variance-weighted, simple mode, MR–Egger, weighted median, and weighted mode. Multiple sensitivity analyses were conducted to confirm the reliability of the MR data. Ultimately, mediation analysis was employed to ascertain the path that leads from immunocytes to plasma metabolites. Results: Among the 20 immune cells and HCC for East Asians, causal links were found, with one showing an inverse correlation. In addition, 36 metabolites were significantly associated with HCC for East Asians. Through analysis of established causative metabolites, we identified a strong correlation between the glycerophospholipid metabolic pathway and HCC for East Asians. By employing a two-step MR analysis, we identified 11 immunocytes that are causally linked to HCC for East Asians through the mediation of 14 plasma metabolites, with Linolenate [α or γ; (18:3n3 or 6)] levels showing the highest mediation proportion (19.3%). Conclusions: Our findings affirm the causal links among immunocytes, plasma metabolites, and HCC in eastern Asia populations by calculating the percentage of the impact that is influenced by plasma metabolites. This study offers innovative perspectives on the early detection, diagnosis, and therapy of HCC. [ABSTRACT FROM AUTHOR]

Tufa deposits have significant potential for reconstructing past lake-level fluctuations. Here, we conducted U-Th dating of tufa deposits exposed along the shoreline of Longmu Co Lake in the northwestern Tibetan Plateau to reconstruct its water level history during the middle-late Holocene. Our data demonstrate that Longmu Co Lake reached its highest level (61 m above the present level) at around 7.4 ka in response to the strengthened Indian Summer Monsoon and increased glacial meltwater; its lake level subsequently decreased due to solar insolation-induced decline in summer monsoon and glacial meltwater. Moreover, we find that the lake level experienced an abrupt decline at ~2.2 ka with a maximum amplitude of 13 m, probably owing to the rapid cooling of the local climate. The δ18O and δ13C of Longmu Co tufa also show a covariance trend, which supports the regional climate change reflected by the lake level fluctuation of Longmu Co. Additionally, we observed an inverse correlation between initial δ234U content in tufa and lake level variation, suggesting that initial calcium δ234U can serve as a proxy for reconstructing environmental changes. Our study therefore implies that lake tufa as a reliable archive for accurately reconstructing lake level changes. [ABSTRACT FROM AUTHOR]