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With the use of a completely self-contained, pre-evacuated, and disposable suction apparatus, endometrial suction biopsy was performed in 250 patients presenting with abnormal uterine bleeding or for an infertility evaluation. The instrument's components and performance features are described, as well as the distribution of tissue diagnoses. Biopsy provided tissue sufficient for diagnosis in 90 per cent of cases where tissue was obtained. In the postmenopausal subgroup, hyperplastic transformation was seen in 28/71 (39 per cent) women, and occult adenocarcinoma was diagnosed in another nine (12 per cent). Over-all instrument performance was very good.