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1. Characteristics of patients with hypertension in a population with type 2 diabetes mellitus. Results from the Turkish Nationwide SurvEy of Glycemic and Other Metabolic Parameters of Patients with Diabetes Mellitus (TEMD Hypertension Study)

Author

Güldiken, Sibel, Aytürk, Semra, Yilmaz, Murat, Aşik, Mehmet, Dinççağ, Nevin, Satman, İlhan, Çakmak, Ramazan, Türker, Fulya, İdiz, Cemile, Hacişahinoğullari, Hülya, Bağdemir, Elif, Yildiz, Büşra, Yumuk, Volkan Demirhan, Haliloğlu, Özlem, Salman, Serpil, Sancak, Seda, Özsari, Levent, Çağiltay, Eylem, Deyneli, Oğuzhan, İmre, Eren, Gönen, Sait, Boysan, Şerife Nur, Altuntaş, Yüksel, Öztürk, FeyzaYener, Mert, Meral, Pişkinpaşa, Hamide, Aydin, Hasan, İmamoğlu, Şazi, Ersoy, Canan, Öz Gül, Özen, Küçüksaraç Kiyici, Sinem, Çetinarslan, Berrin, Selek, Alev, Doğru, Teoman, Kirik, Ali, Kebapçi, Nur, Efe, Belgin, Kaya, Ahmet, Çordan, İlker, Baldane, Süleyman, Kiraç, Cem Onur, Sönmez, Alper, Haymana, Cem, Demirci, İbrahim, Çapa, Zehra, Barçın, Cem, Cesur, Mustafa, Yetkin, İlhan, Çorapçioğlu, Demet, Canlar, Şule, Yildiz, Okan Bülent, Şendur, Süleyman Nahit, Çakir, Bekir, Özdemir, Didem, Çorakçi, Ahmet, Kutlu, Mustafa, Başçil Tütüncü, Neslihan, Bozkuş, Yusuf, Çakal, Erman, Demirbaş, Berrin, Ertek, Sibel, Altay, Mustafa, Dağdeviren, Murat, Dizdar, Oğuzhan Sıtkı, Bayram, Fahri, Abedi, Amir Hassein, Çetinkalp, Şevki, Özişik, Hatice, Örük, Güzide Gonca, Yener, Serkan, Saydam, Başak Özgen, Güney, Engin, Ünübol, Mustafa, Yaylali, Güzin Fidan, Topsakal, Şenay, Hekimsoy, Zeliha, Akbaba, Gülhan, Aslan, İbrahim, Balci, Mustafa Kemal, Dalkiran, Şefika, Akbay, Esen, Gül, Kamile, Gürkan, Eren, Ağbaht, Kemal, Yilmaz, Müge Özsan, Bozkirli, Emre, Tetiker, B.Tamer, Çetinkaya Altuntaş, Seher, Atmaca, Ayşegül, Durmuş, Elif Tutku, Mete, Türkan, Kutlutürk, Faruk, Küçükler, Ferit Kerim, Dikbaş, Oğuz, Akin, Şafak, Nuhoğlu, İrfan, Ersöz, Halil Önder, Bayraktaroğlu, Taner, Çarlioğlu, Ayşe Kargılı, Şişman, Pınar, Şahin, İbrahim, Çetin, Sedat, Çapoğlu, İlyas, Akbaş, Emin Murat, Üçler, Rıfkı, Sabuncu, Tevfik, Eren, Mehmet Ali, Tuzcu, Alpaslan Kemal, Pekkolay, Zafer, Özkaya, Mesut, Araz, Mustafa, Sonmez, Alper, Sahin, Ibrahim, and Satman, Ilhan

Published
2021
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2. Turkish nationwide survEy of glycemic and other Metabolic parameters of patients with Diabetes mellitus (TEMD study)

Author

Guldiken, Sibel, Ayturk, Semra, Yilmaz, Murat, Asik, Mehmet, Dinccag, Nevin, Cakmak, Ramazan, Turker, Fulya, Idiz, Cemile, Hacisahinogullari, Hulya, Bagdemir, Elif, Yildiz, Busra, Yumuk, Volkan Demirhan, Haliloglu, Ozlem, Sancak, Seda, Ozsari, Levent, Cagiltay, Eylem, Deyneli, Oguzhan, Imre, Eren, Gonen, Sait, Boysan, S. Nur, Altuntas, Yuksel, Ozturk, Feyza Yener, Mert, Meral, Piskinpasa, Hamide, Aydin, Hasan, Imamoglu, Sazi, Ersoy, Canan, Gul, Ozen Oz, Kucuksarac Kiyici, Sinem, Cetinarslan, Berrin, Selek, Alev, Dogru, Teoman, Kirik, Ali, Kebapci, Nur, Efe, Belgin, Kaya, Ahmet, Cordan, Ilker, Baldane, Suleyman, Kirac, Cem Onur, Demirci, Ibrahim, Capa, Zehra, Cesur, Mustafa, Yetkin, Ilhan, Corapcioglu, Demet, Canlar, Sule, Bulent Yildiz, Okan, Sendur, Suleyman Nahit, Cakir, Bekir, Ozdemir, Didem, Corakci, Ahmet, Kutlu, Mustafa, Bascil Tutuncu, Neslihan, Bozkus, Yusuf, Cakal, Erman, Demirbas, Berrin, Ertek, Sibel, Altay, Mustafa, Dagdeviren, Murat, Abedi, Amir Hassein, Cetinkalp, Sevki, Ozisik, Hatice, Oruk, Guzide Gonca, Yener, Serkan, Saydam, Basak Ozgen, Guney, Engin, Unubol, Mustafa, Yaylali, Guzin Fidan, Topsakal, Senay, Hekimsoy, Zeliha, Akbaba, Gulhan, Aslan, Ibrahim, Balci, Mustafa Kemal, Dalkiran, Sefika, Akbay, Esen, Gul, Kamile, Agbaht, Kemal, Yilmaz, Muge Ozsan, Bozkirli, Emre, Tetiker, B. Tamer, Cetinkaya Altuntas, Seher, Atmaca, Aysegul, Durmuş, Elif Tutku, Mete, Turkan, Kutluturk, Faruk, Kucukler, Ferit Kerim, Dikbas, Oguz, Akin, Safak, Nuhoglu, Irfan, Ersoz, Halil Onder, Bayraktaroglu, Taner, Sisman, Pınar, Sahin, Ibrahim, Cetin, Sedat, Capoglu, Ilyas, Akbas, Emin Murat, Ucler, Rıfkı, Eren, Mehmet Ali, Tuzcu, Alpaslan Kemal, Pekkolay, Zafer, Ozkaya, Mesut, Araz, Mustafa, Sonmez, Alper, Haymana, Cem, Bayram, Fahri, Salman, Serpil, Dizdar, Oguzhan Sitki, Gurkan, Eren, Kargili Carlıoglu, Ayse, Barcin, Cem, Sabuncu, Tevfik, and Satman, Ilhan

Published
2018
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15. Impact of Obesity on the Metabolic Control of Type 2 Diabetes: Results of the Turkish Nationwide Survey of Glycemic and Other Metabolic Parameters of Patients with Diabetes Mellitus (TEMD Obesity Study)

Author

Capoglu, Ilyas, Sonmez, Alper, Yumuk, Volkan, Haymana, Cem, Demirci, Ibrahim, Barcin, Cem, Kiyici, Sinem, GÜLDİKEN, SİBEL, Oruk, Gonca, Saydam, Basak Ozgen, BALDANE, SÜLEYMAN, KUTLUTÜRK, FARUK, KÜÇÜKLER, FERİT KERİM, Deyneli, Oguzhan, Cetinarslan, Berrin, SABUNCU, TEVFİK, BAYRAM, FAHRİ, Satman, Ilhan, Ayturk, Semra, Yilmaz, Murat, Asik, Mehmet, Dinccag, Nevin, Cakmak, Ramazan, Idiz, Cemile, Hacisahinogullari, Hulya, Bagdemir, Elif, Yildiz, Busra, Haliloglu, Ozlem, Sancak, Seda, Ozsari, Levent, Cagiltay, Eylem, Imre, Eren, Sait Gonen, Sait Gonen, Boysan, S. Nur, Altuntas, Yuksel, Ozturk, Feyza Yener, Mert, Meral, Piskinpasa, Hamide, Aydin, Hasan, ERSOY, CANAN, Oz Gul, Ozen, SELEK, ALEV, Dogru, Teoman, Kirik, Ali, Kebapci, Nur, Efe, Belgin, Kaya, Ahmet, Cordan, Ilker, KIRAÇ, CEM ONUR, Capa, Zehra, Cesur, Mustafa, Yetkin, Ilhan, ÇORAPÇIOĞLU, DEMET, Canlar, Sule, YILDIZ, OKAN BÜLENT, ŞENDUR, SÜLEYMAN NAHİT, ÇAKIR, BEKİR, ÖZDEMİR, DİDEM, BAŞÇIL TÜTÜNCÜ, NESLİHAN, Bozkus, Yusuf, Cakal, Erman, Demirbas, Berrin, Ertek, Sibel, Altay, Mustafa, Dagdeviren, Murat, ABEDİ, AMİR HOSSEİN, ÇETİNKALP, ŞEVKİ, ÖZIŞIK, HATİCE, Yener, Serkan, GÜNEY, ENGİN, ÜNÜBOL, MUSTAFA, YAYLALI, GÜZİN FİDAN, TOPSAKAL, ŞENAY, HEKİMSOY, ZELİHA, Akbaba, Gulhan, Aslan, Ibrahim, BALCI, MUSTAFA KEMAL, Dalkiran, Sefika, AKBAY, Esen, GÜL, KAMİLE, Agbaht, Kemal, YILMAZ, MÜGE ÖZSAN, TETİKER, BEKİR TAMER, ÇETİNKAYA ALTUNTAŞ, SEHER, ATMACA, AYŞEGÜL, DURMUŞ, ELİF TUTKU, Mete, Turkan, DİKBAŞ, OĞUZ, Akin, Safak, NUHOĞLU, İRFAN, Ersoz, Halil Onder, BAYRAKTAROĞLU, TANER, Sisman, Pinar, ŞAHİN, İBRAHİM, Cetin, Sedat, AKBAŞ, EMİN MURAT, Ucler, Rifki, EREN, MEHMET ALİ, TUZCU, ALPASLAN KEMAL, PEKKOLAY, ZAFER, Ozkaya, Mesut, Araz, Mustafa, Salman, Serpil, Dizdar, Oguzhan Sitki, GÜRKAN, EREN, Kargili Carlioglu, Ayse, Imamoglu, Sazi, Bozkirli, Emre, Kutlu, Mustafa, Corakci, Ahmet, Turker, Fulya, Ege Üniversitesi, Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri/İç Hastalıkları Bölümü., Ersoy, Canan, Öz Gül, Özen, AAH-8861-2021, Zonguldak Bülent Ecevit Üniversitesi, Sonmez, A, Yumuk, V, Haymana, C, Demirci, I, Barcin, C, Kiyici, S, Kargili Carlioglu, A, Yeditepe Üniversitesi, [Belirlenecek], İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, OMÜ, Hitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çukurova Üniversitesi, Tıp Fakültesi, Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı, Dikbaş, Oğuz, Selçuk Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, and Baldane, Süleyman

Subjects
Male, Health (social science), Turkey, Glucose blood level, Body Mass Index, 0302 clinical medicine, Pregnancy, Surveys and Questionnaires, Insulin, Endocrinology & metabolism, Anthropometry, Correlation analysis, Health survey, Multicenter study, Clinical trial, Blood, lcsh:Nutrition. Foods and food supply, Human, medicine.medical_specialty, HbA1c, lcsh:TX341-641, Major clinical study, Article, Education, Hydroxymethylglutaryl coenzyme A reductase inhibitor, 03 medical and health sciences, Age, Physiology (medical), Humans, Attainment, Cross-sectional study, Glycemic, Demography, Aged, 030109 nutrition & dietetics, Physical inactivity, Questionnaire, Medical record, Follow up, Hlucose blood level, medicine.disease, Cardiovascular risk, Obesity, Cross-Sectional Studies, Lipid metabolism, Dyslipidemia, Diabetes Mellitus, Type 2, Non insulin dependent diabetes mellitus, Complication, 0301 basic medicine, Blood Glucose, Renal Replacement Therapy, Nephrology, Cardiovascular Disease, Type 2 diabetes, Overweight, Turkey (republic), Turkey (bird), Prevalence, Disease, Antihypertensive agent, Metabolic parameters, lcsh:RC620-627, Priority journal, Obesity management, Smoking, Middle Aged, lcsh:Nutritional diseases. Deficiency diseases, Body mass, Microangiopathy, Hypertension, Tertiary health care, Blood pressure, Female, medicine.symptom, Blood-pressure, Research Article, Adult, Health care quality, 030209 endocrinology & metabolism, Management of obesity, Association, Diabetes mellitus, Internal medicine, Metabolic regulation, medicine, Nutrition & dietetics, Oral antidiabetic agent, Disease severity, business.industry, Gender, Weight, Metabolism, Metabolic control analysis, business, Follow-Up Studies
Abstract

Background: Obesity is the main obstacle for metabolic control in patients with type 2 diabetes. Turkey has the highest prevalence of obesity and type 2 diabetes in Europe. The effect of obesity on the metabolic control, and the macro-and microvascular complications of patients are not apparent. Objectives: This nationwide survey aimed to investigate the prevalence of overweight and obesity among patients with type 2 diabetes and to search for the impact of obesity on the metabolic control of these patients. We also investigated the independent associates of obesity in patients with type 2 diabetes. Methods: We consecutively enrolled patients who were under follow-up for at least 1 year in 69 tertiary healthcare units in 37 cities. The demographic, anthropometric, and clinical data including medications were recorded. Patients were excluded if they were pregnant, younger than 18 years, had decompensated liver disease, psychiatric disorders interfering with cognition or compliance, had bariatric surgery, or were undergoing renal replacement therapy. Results: Only 10% of patients with type 2 diabetes (n = 4,648) had normal body mass indexes (BMI), while the others were affected by overweight (31%) or obesity (59%). Women had a significantly higher prevalence of obesity (53.4 vs. 40%) and severe obesity (16.6 vs. 3.3%). Significant associations were present between high BMI levels and lower education levels, intake of insulin, antihypertensives and statins, poor metabolic control, or the presence of microvascular complications. Age, gender, level of education, smoking, and physical inactivity were the independent associates of obesity in patients with type 2 diabetes. Conclusion: The TEMD Obesity Study shows that obesity is a major determinant of the poor metabolic control in patients with type 2 diabetes. These results underline the importance of prevention and management of obesity to improve health care in patients with type 2 diabetes. Also, the results point out the independent sociodemographic and clinical associates of obesity, which should be the prior targets to overcome, in the national fight with obesity. (c) 2019 The Author(s) Published by S. Karger AG, Basel, C1 [Sonmez, Alper; Haymana, Cem; Demirci, Ibrahim] Univ Hlth Sci, Gulhane Sch Med, Dept Endocrinol & Metab, TR-06018 Ankara, Turkey., [Yumuk, Volkan] Istanbul Univ, Cerrahpasa Med Fac, Dept Endocrinol & Metab, Istanbul, Turkey., [Barcin, Cem] Univ Hlth Sci, Gulhane Sch Med, Dept Cardiol, Ankara, Turkey., [Kiyici, Sinem] Univ Hlth Sci, Bursa Yuksek Ihtisas Training & Res Hosp, Dept Endocrinol & Metab, Bursa, Turkey., [Guldiken, Sibel] Trakya Univ, Med Fac, Dept Endocrinol & Metab, Edirne, Turkey., [Oruk, Gonca] Izmir Katip Celebi Univ, Ataturk Educ & Res Hosp, Dept Endocrinol & Metab, Izmir, Turkey., [Saydam, Basak Ozgen] Dokuz Eylul Univ, Med Fac, Dept Endocrinol & Metab, Izmir, Turkey., [Baldane, Suleyman] Selcuk Univ, Med Fac, Dept Endocrinol & Metab, Konya, Turkey., [Kutluturk, Faruk] Gaziosmanpasa Univ, Med Fac, Dept Endocrinol & Metab, Tokat, Turkey., [Kucukler, Ferit Kerim] Hitit Univ, Med Fac, Dept Endocrinol & Metab, Corum, Turkey., [Deyneli, Oguzhan] Marmara Univ, Med Fac, Dept Endocrinol & Metab, Istanbul, Turkey., [Cetinarslan, Berrin] Kocaeli Univ, Med Fac, Dept Endocrinol & Metab, Kocaeli, Turkey., [Sabuncu, Tevfik] Harran Univ, Med Fac, Dept Endocrinol & Metab, Urfa, Turkey., [Bayram, Fahri] Erciyes Univ, Med Fac, Dept Endocrinol & Metab, Kayseri, Turkey., [Satman, Ilhan] Istanbul Univ, Med Fac, Dept Endocrinol & Metab, Istanbul, Turkey., [Ayturk, Semra] Trakya Univ, Sch Med, Dept Endocrinol & Metab, Edirne, Turkey., [Yilmaz, Murat] Corlu REYAP Private Hosp, Dept Endocrinol & Metab, Corlu, Turkey., [Asik, Mehmet] Canakkale 18 March Univ, Sch Med, Dept Endocrinol & Metab, Canakkale, Turkey., [Dinccag, Nevin; Cakmak, Ramazan; Turker, Fulya; Idiz, Cemile; Hacisahinogullari, Hulya; Bagdemir, Elif; Yildiz, Busra; Haliloglu, Ozlem] Istanbul Univ, Sch Med, Dept Endocrinol & Metab, Cerrahpasa, Turkey., [Sancak, Seda] Univ Hlth Sci, Sch Med, Fatih Sultan Mehmet Training & Res Hosp, Dept Endocrinol & Metab, Istanbul, Turkey., [Ozsari, Levent; Cagiltay, Eylem] Univ Hlth Sci, Sch Med, Sultanabdulhamit Training & Res Hosp, Dept Endocrinol & Metab, Istanbul, Turkey., [Imre, Eren] Marmara Univ, Sch Med, Dept Endocrinol & Metab, Istanbul, Turkey., [Sait Gonen; Boysan, S. Nur] Istanbul Sci Univ, Sch Med, Dept Endocrinol & Metab, Istanbul, Turkey., [Altuntas, Yuksel; Ozturk, Feyza Yener] Univ Hlth Sci, Sch Med, Sisli Hamidiye Etfal Training & Res Hosp, Dept Endocrinol & Metab, Istanbul, Turkey., [Mert, Meral; Piskinpasa, Hamide] Univ Hlth Sci, Istanbul Bakirkoy Dr Sadi Konuk Training & Res Ho, Sch Med, Dept Endocrinol & Metab, Istanbul, Turkey., [Aydin, Hasan] Yeditepe Univ, Sch Med, Dept Endocrinol & Metab, Istanbul, Turkey., [Ersoy, Canan; Oz Gul, Ozen] Uludag Univ, Sch Med, Dept Endocrinol & Metab, Bursa, Turkey., [Selek, Alev] Kocaeli Univ, Sch Med, Dept Endocrinol & Metab, Kocaeli, Turkey., [Dogru, Teoman; Kirik, Ali] Balikesir Univ, Sch Med, Dept Internal Med, Balikesir, Turkey., [Kebapci, Nur; Efe, Belgin] Eskisehir Osmangazi Univ, Sch Med, Dept Endocrinol & Metab, Odunpazari Eskisehir, Turkey., [Kaya, Ahmet; Cordan, Ilker] Necmettin Erbakan Univ, Sch Med, Dept Endocrinol & Metab, Konya, Turkey., [Kirac, Cem Onur] Selcuk Univ, Sch Med, Dept Endocrinol & Metab, Konya, Turkey., [Capa, Zehra] Univ Hlth Sci, Gulhane Sch Med, Ankara, Turkey., [Capa, Zehra] Gulhane Training & Res Hosp, Dept Endocrinol & Metab, Ankara, Turkey., [Cesur, Mustafa] Private Guven Hosp, Dept Endocrinol & Metab, Ankara, Turkey., [Yetkin, Ilhan] Gazi Univ, Sch Med, Dept Endocrinol & Metab, Ankara, Turkey., [Corapcioglu, Demet; Canlar, Sule] Ankara Univ, Sch Med, Dept Endocrinol & Metab, Ankara, Turkey., [Yildiz, Okan Bulent; Sendur, Suleyman Nahit] Hacettepe Univ, Sch Med, Dept Endocrinol & Metab, Ankara, Turkey., [Cakir, Bekir; Ozdemir, Didem] Yildirim Beyazit Univ, Sch Med, Dept Endocrinol & Metab, Ankara, Turkey., [Corakci, Ahmet] Ufuk Univ, Sch Med, Dept Endocrinol & Metab, Ankara, Turkey., [Kutlu, Mustafa] Private Bayindir Hosp, Dept Endocrinol & Metab, Ankara, Turkey., [Bascil Tutuncu, Neslihan; Bozkus, Yusuf] Baskent Univ, Sch Med, Dept Endocrinol & Metab, Ankara, Turkey., [Cakal, Erman] Univ Hlth Sci, Sch Med, Diskapi Yildirim Beyazit Training & Res Hosp, Dept Endocrinol & Metab, Ankara, Turkey., [Demirbas, Berrin] TOBB Univ, Sch Med, Dept Endocrinol & Metab, Ankara, Turkey., [Ertek, Sibel] Private Mem Hosp, Dept Endocrinol & Metab, Ankara, Turkey., [Altay, Mustafa; Dagdeviren, Murat] Univ Hlth Sci, Sch Med, Kecioren Training & Res Hosp, Dept Endocrinol & Metab, Ankara, Turkey., [Abedi, Amir Hassein] Erciyes Univ, Sch Med, Dept Endocrinol & Metab, Kayseri, Turkey., [Cetinkalp, Sevki; Ozisik, Hatice] Ege Univ, Sch Med, Dept Endocrinol & Metab, Izmir, Turkey., [Yener, Serkan] Dokuz Eylul Univ, Sch Med, Dept Endocrinol & Metab, Izmir, Turkey., [Guney, Engin; Unubol, Mustafa] Adnan Menderes Univ, Sch Med, Dept Endocrinol & Metab, Aydin, Turkey., [Yaylali, Guzin Fidan; Topsakal, Senay] Pamukkale Univ, Sch Med, Dept Endocrinol & Metab, Denizli, Turkey., [Hekimsoy, Zeliha] Celal Bayar Univ, Sch Med, Dept Endocrinol & Metab, Manisa, Turkey., [Akbaba, Gulhan] Mugla Univ, Sch Med, Dept Endocrinol & Metab, Mugla, Turkey., [Aslan, Ibrahim] Univ Hlth Sci, Antalya Training & Res Hosp, Sch Med, Dept Endocrinol & Metab, Antalya, Turkey., [Balci, Mustafa Kemal; Dalkiran, Sefika] Akdeniz Univ, Sch Med, Dept Endocrinol & Metab, Antalya, Turkey., [Akbay, Esen] Mersin Univ, Sch Med, Dept Endocrinol & Metab, Mersin, Turkey., [Gul, Kamile] Kahramanmaras Sutcu Imam Univ, Sch Med, Dept Endocrinol & Metab, Kahramanmaras, Turkey., [Agbaht, Kemal] Private Defne Hosp, Dept Endocrinol & Metab, Antalya, Turkey., [Yilmaz, Muge Ozsan] Mustafa Kemal Univ, Sch Med, Dept Endocrinol & Metab, Antakya, Turkey., [Bozkirli, Emre] Baskent Univ, Adana Training Hosp, Dept Endocrinol & Metab, Ankara, Turkey., [Tetiker, B. Tamer; Cetinkaya Altuntas, Seher] Cukurova Univ, Sch Med, Dept Endocrinol & Metab, Adana, Turkey., [Atmaca, Aysegul; Durmus, Elif Tutku] 19 Mayis Univ, Sch Med, Dept Endocrinol & Metab, Samsun, Turkey., [Mete, Turkan] Univ Hlth Sci, Sch Med, Samsun Training & Res Hosp, Dept Endocrinol & Metab, Samsun, Turkey., [Dikbas, Oguz] Giresun Univ, Sch Med, Dept Endocrinol & Metab, Giresun, Turkey., [Akin, Safak] Recep Tayyip Erdogan Univ, Sch Med, Dept Endocrinol & Metab, Rize, Turkey., [Nuhoglu, Irfan; Ersoz, Halil Onder] Karadeniz Tech Univ, Sch Med, Dept Endocrinol & Metab, Trabzon, Turkey., [Bayraktaroglu, Taner] Bulent Ecevit Univ, Sch Med, Dept Endocrinol & Metab, Zonguldak, Turkey., [Sisman, Pinar] Kars Harakani State Hosp, Dept Endocrinol & Metab, Kars, Turkey., [Sahin, Ibrahim; Cetin, Sedat] Inonu Univ, Sch Med, Dept Endocrinol & Metab, Malatya, Turkey., [Capoglu, Ilyas; Akbas, Emin Murat] Erzincan Univ, Sch Med, Dept Endocrinol & Metab, Erzincan, Turkey., [Ucler, Rifki] Yuzuncu Yil Univ, Sch Med, Dept Endocrinol & Metab, Van, Turkey., [Eren, Mehmet Ali] Harran Univ, Sch Med, Dept Endocrinol & Metab, Sanliurfa, Turkey., [Tuzcu, Alpaslan Kemal; Pekkolay, Zafer] Dicle Univ, Sch Med, Dept Endocrinol & Metab, Diyarbakir, Turkey., [Ozkaya, Mesut] Univ Hlth Sci, Sch Med, Gaziantep Ersin Arslan Res & Training Hosp, Gaziantep, Turkey., [Araz, Mustafa] Gaziantep Univ, Sch Med, Dept Endocrinol & Metab, Gaziantep, Turkey., [Salman, Serpil] Liv Hosp Ulus, Dept Endocrinol & Metab, Istanbul, Turkey., [Dizdar, Oguzhan Sitki] Kayseri Educ & Res Hosp, Dept Internal Med, Kayseri, Turkey., [Gurkan, Eren] Mustafa Kemal Univ, Dept Endocrinol & Metab, Antakya, Turkey., [Kargili Carlioglu, Ayse] Erzurum Reg Educ & Res Hosp, Dept Endocrinol & Metab, Erzurum, Turkey.

Published
2019

20. Turkish nationwide survEy of glycemic and other Metabolic parameters of patients with Diabetes mellitus (TEMD study)

Author

Sonmez, Alper, primary, Haymana, Cem, additional, Bayram, Fahri, additional, Salman, Serpil, additional, Dizdar, Oguzhan Sitki, additional, Gurkan, Eren, additional, Kargili Carlıoglu, Ayse, additional, Barcin, Cem, additional, Sabuncu, Tevfik, additional, Satman, Ilhan, additional, Guldiken, Sibel, additional, Ayturk, Semra, additional, Yilmaz, Murat, additional, Asik, Mehmet, additional, Dinccag, Nevin, additional, Cakmak, Ramazan, additional, Turker, Fulya, additional, Idiz, Cemile, additional, Hacisahinogullari, Hulya, additional, Bagdemir, Elif, additional, Yildiz, Busra, additional, Yumuk, Volkan Demirhan, additional, Haliloglu, Ozlem, additional, Sancak, Seda, additional, Ozsari, Levent, additional, Cagiltay, Eylem, additional, Deyneli, Oguzhan, additional, Imre, Eren, additional, Gonen, Sait, additional, Boysan, S. Nur, additional, Altuntas, Yuksel, additional, Ozturk, Feyza Yener, additional, Mert, Meral, additional, Piskinpasa, Hamide, additional, Aydin, Hasan, additional, Imamoglu, Sazi, additional, Ersoy, Canan, additional, Gul, Ozen Oz, additional, Kucuksarac Kiyici, Sinem, additional, Cetinarslan, Berrin, additional, Selek, Alev, additional, Dogru, Teoman, additional, Kirik, Ali, additional, Kebapci, Nur, additional, Efe, Belgin, additional, Kaya, Ahmet, additional, Cordan, Ilker, additional, Baldane, Suleyman, additional, Kirac, Cem Onur, additional, Demirci, Ibrahim, additional, Capa, Zehra, additional, Cesur, Mustafa, additional, Yetkin, Ilhan, additional, Corapcioglu, Demet, additional, Canlar, Sule, additional, Bulent Yildiz, Okan, additional, Sendur, Suleyman Nahit, additional, Cakir, Bekir, additional, Ozdemir, Didem, additional, Corakci, Ahmet, additional, Kutlu, Mustafa, additional, Bascil Tutuncu, Neslihan, additional, Bozkus, Yusuf, additional, Cakal, Erman, additional, Demirbas, Berrin, additional, Ertek, Sibel, additional, Altay, Mustafa, additional, Dagdeviren, Murat, additional, Abedi, Amir Hassein, additional, Cetinkalp, Sevki, additional, Ozisik, Hatice, additional, Oruk, Guzide Gonca, additional, Yener, Serkan, additional, Saydam, Basak Ozgen, additional, Guney, Engin, additional, Unubol, Mustafa, additional, Yaylali, Guzin Fidan, additional, Topsakal, Senay, additional, Hekimsoy, Zeliha, additional, Akbaba, Gulhan, additional, Aslan, Ibrahim, additional, Balci, Mustafa Kemal, additional, Dalkiran, Sefika, additional, Akbay, Esen, additional, Gul, Kamile, additional, Agbaht, Kemal, additional, Yilmaz, Muge Ozsan, additional, Bozkirli, Emre, additional, Tetiker, B. Tamer, additional, Cetinkaya Altuntas, Seher, additional, Atmaca, Aysegul, additional, Durmuş, Elif Tutku, additional, Mete, Turkan, additional, Kutluturk, Faruk, additional, Kucukler, Ferit Kerim, additional, Dikbas, Oguz, additional, Akin, Safak, additional, Nuhoglu, Irfan, additional, Ersoz, Halil Onder, additional, Bayraktaroglu, Taner, additional, Sisman, Pınar, additional, Sahin, Ibrahim, additional, Cetin, Sedat, additional, Capoglu, Ilyas, additional, Akbas, Emin Murat, additional, Ucler, Rıfkı, additional, Eren, Mehmet Ali, additional, Tuzcu, Alpaslan Kemal, additional, Pekkolay, Zafer, additional, Ozkaya, Mesut, additional, and Araz, Mustafa, additional

Published
2018
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22. The Effects of Trandolapril on Lipid Peroxidation and Anti-oxidant Systems in Hypertensive Type 2 Diabetic Patients

Author

TUNCEL, ERCAN, ERSOY, CANAN, ERTURK, ERDINC, SERDAR, ZEHRA, GURSOY, NILGUN, IMAMOGLU, SAZI, and ARINIK, AYHAN

Subjects
Diabetes -- Research, Health
Abstract

One of the important causes of the chronic complications of diabetes mellitus is metabolic stress which increases oxidative stress that leads to the formation of free radicals and structural and [...]

Published
2000

32. TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction

Author

Topaloglu, A Kemal, primary, Reimann, Frank, additional, Guclu, Metin, additional, Yalin, Ayse Serap, additional, Kotan, L Damla, additional, Porter, Keith M, additional, Serin, Ayse, additional, Mungan, Neslihan O, additional, Cook, Joshua R, additional, Ozbek, Mehmet N, additional, Imamoglu, Sazi, additional, Akalin, N Sema, additional, Yuksel, Bilgin, additional, O'Rahilly, Stephen, additional, and Semple, Robert K, additional

Published
2008
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37. TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction.

Author

Topaloglu, A. Kemal, Reimann, Frank, Guclu, Metin, Yalin, Ayse Serap, Kotan, L. Damla, Porter, Keith M., Serin, Ayse, Mungan, Neslihan O., Cook, Joshua R., Ozbek, Mehmet N., Imamoglu, Sazi, Akalin, N. Sema, Yuksel, Bilgin, O'Rahilly, Stephen, and Semple, Robert K.

Subjects
GENETIC mutation, HYPOGONADISM, TACHYKININS, FOLLICLE-stimulating hormone, STEROID hormones, REPRODUCTIVE health
Abstract

The timely secretion of gonadal sex steroids is essential for the initiation of puberty, the postpubertal maintenance of secondary sexual characteristics and the normal perinatal development of male external genitalia. Normal gonadal steroid production requires the actions of the pituitary-derived gonadotropins, luteinizing hormone and follicle-stimulating hormone. We report four human pedigrees with severe congenital gonadotropin deficiency and pubertal failure in which all affected individuals are homozygous for loss-of-function mutations in TAC3 (encoding Neurokinin B) or its receptor TACR3 (encoding NK3R). Neurokinin B, a member of the substance P–related tachykinin family, is known to be highly expressed in hypothalamic neurons that also express kisspeptin, a recently identified regulator of gonadotropin-releasing hormone secretion. These findings implicate Neurokinin B as a critical central regulator of human gonadal function and suggest new approaches to the pharmacological control of human reproduction and sex hormone-related diseases. [ABSTRACT FROM AUTHOR]

Published
2009
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38. A retrospective analysis of thyroid cancer

Author

Arinik, Ayhan, Erturk, Erdinc, Gursoy, Nilgun, Yerci, Omer, Koran, Nusret, Tuncel, Ercan, and Imamoglu, Sazi

Subjects
DIAGNOSIS
Abstract

We reviewed the results of 2071 thyroidectomies performed during thepast 11 years at Uludag University School of Medicine Hospital. Of all the patients 1602 (77.4%) were women and 469 (22.6%) were men (F:M= 3.4:1). Seventy-eight of the thyroid surgery patients (3.77%) had thyroid carcinoma, with a female to male ratio of 2.0:1. The relativerisk of thyroid cancer in male versus female patients with thyroid nodules was determined to be 1.75:1. Patient distribution by thyroid carcinoma type was: papillary carcinoma 49%, follicular carcinoma 24%,undifferentiated carcinoma 10%, metastatic carcinoma 10%, and medullary carcinoma 6%. Fine needle aspiration biopsy (FNAB) has been used routinely in our hospital for the last 4 years. During this period, the average number of operations decreased from 201 to 130 per year and the surgical diagnosis of thyroid carcinoma increased from 2.85 to 7.65%. We conclude that papillary carcinoma is relatively less prevalent in our population and that fine needle aspiration biopsy is the preferred method of diagnosing nodular thyroid disease. [ABSTRACT FROM AUTHOR]

Published
1996

39. Physical activity alters urinary albumin/ creatinine ratio in type 1 diabetic patient.

Author

Tuncel E, Erturk E, Ersoy C, Kiyici S, Duran C, Kuru N, and Imamoglu S

Abstract

While the best way to identify microalbuminuria is to determine albumin excretion rate (AER) in a 24 h urine sample. Published data have shown that calculation of an albumin/creatinine ratio (ACR) in a spot urine sample has reasonable rate of sensitivity and specificity. We aimed to evaluate the effect of daily exercise on ACR and estimate the best time for the examination of the ACR in a spot urine sample. Sixteen eligible patients with Type 1 diabetes mellitus were asked to perform varying degree of exercise periods. Urinary albumin and creatinine excretion rates during each period were determined. ACR and AER of timed urinary samples were compared with the 24 hour urinary AER. We found significant correlations between timed and 24 hour urinary AER. According to diagnostic performance tests, ACR and AER of timed urine samples were both found to be significantly more sensitive during resting period when compared with mild or moderate active periods. It is concluded that ACR and AER of a timed urine sample are sensitive and specific methods for determining microalbuminuria, while overnight resting samples give the impression of being more diagnostic. Key PointsTimed urine samples can predict microalbuminuria but because of the erroneous urine collections, microalbuminuria measurement should be calculated with creatiniuria measurement.With increasing physical activity during urine collection diagnostic performances of the cut-off values go downhill.For detecting microalbuminuria best results are reached with the early-morning urine samples.

Published
2004

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