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1. An ovine septic shock model of live bacterial infusion

Author

Obonyo, Nchafatso G., Raman, Sainath, Suen, Jacky Y., Peters, Kate M., Phan, Minh-Duy, Passmore, Margaret R., Bouquet, Mahe, Wilson, Emily S., Hyslop, Kieran, Palmieri, Chiara, White, Nicole, Sato, Kei, Farah, Samia M., Gandini, Lucia, Liu, Keibun, Fior, Gabriele, Heinsar, Silver, Ijuin, Shinichi, Kyun Ro, Sun, Abbate, Gabriella, Ainola, Carmen, Sato, Noriko, Lundon, Brooke, Portatadino, Sofia, Rachakonda, Reema H., Schneider, Bailey, Harley, Amanda, See Hoe, Louise E., Schembri, Mark A., Li Bassi, Gianluigi, and Fraser, John F.

Published
2024
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6. Etiology-Based Prognosis of Extracorporeal CPR Recipients After Out-of-Hospital Cardiac Arrest: A Retrospective Multicenter Cohort Study

Author

Sawano, Hirotaka, Egawa, Yuko, Kato, Shunichi, Bunya, Naofumi, Kasai, Takehiko, Ijuin, Shinichi, Nakayama, Shinichi, Kanda, Jun, Kanou, Seiya, Takada, Hiroaki, Inoue, Kazushige, Takeuchi, Ichiro, Honzawa, Hiroshi, Kobayashi, Makoto, Hamagami, Tomohiro, Takayama, Wataru, Otomo, Yasuhiro, Maekawa, Kunihiko, Shimizu, Takafumi, Nara, Satoshi, Nasu, Michitaka, Takahashi, Kuniko, Hagiwara, Yoshihiro, Kushimoto, Shigeki, Fukuda, Reo, Ogura, Takayuki, Shiraishi, Shin-ichiro, Zushi, Ryosuke, Otani, Norio, Kikuchi, Migaku, Watanabe, Kazuhiro, Nakagami, Takuo, Shoko, Tomohisa, Kitamura, Nobuya, Otani, Takayuki, Matsuoka, Yoshinori, Aoki, Makoto, Sakuraya, Masaaki, Arimoto, Hideki, Homma, Koichiro, Naito, Hiromichi, Nakao, Shunichiro, Okazaki, Tomoya, Tahara, Yoshio, Okamoto, Hiroshi, Kunikata, Jun, Yokoi, Hideto, Takiguchi, Toru, Tominaga, Naoki, Hamaguchi, Takuro, Seki, Tomohisa, Nakata, Jun, Yamamoto, Takeshi, Tagami, Takashi, Inoue, Akihiko, Hifumi, Toru, Sakamoto, Tetsuya, Kuroda, Yasuhiro, and Yokobori, Shoji

Published
2024
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9. Prognostic Significance of Signs of Life in Out-of-Hospital Cardiac Arrest Patients Undergoing Extracorporeal Cardiopulmonary Resuscitation*

Author

Bunya, Naofumi, Ohnishi, Hirofumi, Kasai, Takehiko, Katayama, Yoichi, Kakizaki, Ryuichiro, Nara, Satoshi, Ijuin, Shinichi, Inoue, Akihiko, Hifumi, Toru, Sakamoto, Tetsuya, Kuroda, Yasuhiro, Narimatsu, Eichi, Okamoto, Hiroshi, Kunikata, Jun, Yokoi, Hideto, Sawano, Hirotaka, Egawa, Yuko, Kato, Shunichi, Sugiyama, Kazuhiro, Nakayama, Shinichi, Kanda, Jun, Kanou, Seiya, Takiguchi, Toru, Yokobori, Shoji, Takada, Hiroaki, Inoue, Kazushige, Takeuchi, Ichiro, Honzawa, Hiroshi, Kobayashi, Makoto, Hamagami, Tomohiro, Takayama, Wataru, Otomo, Yasuhiro, Maekawa, Kunihiko, Shimizu, Takafumi, Nasu, Michitaka, Takahashi, Kuniko, Hagiwara, Yoshihiro, Kushimoto, Shigeki, Fukuda, Reo, Ogura, Takayuki, Shiraishi, Shin-Ichiro, Zushi, Ryosuke, Otani, Norio, Kikuchi, Migaku, Watanabe, Kazuhiro, Nakagami, Takuo, Shoko, Tomohisa, Kitamura, Nobuya, Otani, Takayuki, Matsuoka, Yoshinori, Aoki, Makoto, Sakuraya, Masaaki, Arimoto, Hideki, Homma, Koichiro, Naito, Hiromichi, Nakao, Shunichiro, Okazaki, Tomoya, and Tahara, Yoshio

Published
2024
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12. Transient return of spontaneous circulation related to favourable outcomes in out-of-hospital cardiac arrest patients resuscitated with extracorporeal cardiopulmonary resuscitation: A secondary analysis of the SAVE-J II study

Author

Sawano, Hirotaka, Egawa, Yuko, Sugiyama, Kazuhiro, Tanabe, Maki, Bunya, Naofumi, Kasai, Takehiko, Ijuin, Shinichi, Nakayama, Shinichi, Kanda, Jun, Kanou, Seiya, Takiguchi, Toru, Yokobori, Shoji, Takada, Hiroaki, Inoue, Kazushige, Takeuchi, Ichiro, Honzawa, Hiroshi, Kobayashi, Makoto, Hamagami, Tomohiro, Takayama, Wataru, Otomo, Yasuhiro, Maekawa, Kunihiko, Shimizu, Takafumi, Nara, Satoshi, Nasu, Michitaka, Takahashi, Kuniko, Hagiwara, Yoshihiro, Kushimoto, Shigeki, Fukuda, Reo, Ogura, Takayuki, Shiraishi, Shin-ichiro, Zushi, Ryosuke, Otani, Norio, Kikuchi, Migaku, Watanabe, Kazuhiro, Nakagami, Takuo, Shoko, Tomohisa, Kitamura, Nobuya, Otani, Takayuki, Matsuoka, Yoshinori, Aoki, Makoto, Sakuraya, Masaaki, Arimoto, Hideki, Homma, Koichiro, Naito, Hiromichi, Nakao, Shunichiro, Okazaki, Tomoya, Tahara, Yoshio, Okamoto, Hiroshi, Kunikata, Jun, Yokoi, Hideto, Hifumi, Toru, Inoue, Akihiko, Abe, Toshikazu, Sakamoto, Tetsuya, and Kuroda, Yasuhiro

Published
2022
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14. Extracorporeal cardiopulmonary resuscitation in adult patients with out-of-hospital cardiac arrest: a retrospective large cohort multicenter study in Japan

Author

Inoue, Akihiko, Hifumi, Toru, Sakamoto, Tetsuya, Okamoto, Hiroshi, Kunikata, Jun, Yokoi, Hideto, Sawano, Hirotaka, Egawa, Yuko, Kato, Shunichi, Sugiyama, Kazuhiro, Bunya, Naofumi, Kasai, Takehiko, Ijuin, Shinichi, Nakayama, Shinichi, Kanda, Jun, Kanou, Seiya, Takiguchi, Toru, Yokobori, Shoji, Takada, Hiroaki, Inoue, Kazushige, Takeuchi, Ichiro, Honzawa, Hiroshi, Kobayashi, Makoto, Hamagami, Tomohiro, Takayama, Wataru, Otomo, Yasuhiro, Maekawa, Kunihiko, Shimizu, Takafumi, Nara, Satoshi, Nasu, Michitaka, Takahashi, Kuniko, Hagiwara, Yoshihiro, Kushimoto, Shigeki, Fukuda, Reo, Ogura, Takayuki, Shiraishi, Shin-ichiro, Zushi, Ryosuke, Otani, Norio, Kikuchi, Migaku, Watanabe, Kazuhiro, Nakagami, Takuo, Shoko, Tomohisa, Kitamura, Nobuya, Otani, Takayuki, Matsuoka, Yoshinori, Aoki, Makoto, Sakuraya, Masaaki, Arimoto, Hideki, Homma, Koichiro, Naito, Hiromichi, Nakao, Shunichiro, Okazaki, Tomoya, Tahara, Yoshio, and Kuroda, Yasuhiro

Published
2022
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15. A novel echocardiographic parameter considering left ventricular afterload during V‐A ECMO support.

Author

Sato, Kei, Heinsar, Silver, Chan, Jonathan, Farah, Samia M., Wildi, Karin, Obonyo, Nchafatso G., Liu, Keibun, Ainola, Carmen, Sato, Noriko, Abbate, Gabriella, Wilson, Emily S., Bouquet, Mahé, Hyslop, Kieran, Passmore, Margaret R., Ijuin, Shinichi, Ro, Sun Kyun, Fior, Gabriele, Gandini, Lucia, Lundon, Brooke, and Platts, David G.

Subjects
CARDIOGENIC shock, EXTRACORPOREAL membrane oxygenation, ARTIFICIAL blood circulation, PROGNOSIS, ECHOCARDIOGRAPHY
Abstract

Background: Left ventricular stroke work index (LVSWI) and cardiac power index (CPI) account for the haemodynamic load of the left ventricle and are promising prognostic values in cardiogenic shock. However, accurately and non‐invasively measuring these parameters during veno‐arterial extracorporeal membrane oxygenation (V‐A ECMO) is challenging and potentially biased by the extracorporeal circulation. This study aimed to investigate, in an ovine model of cardiogenic shock, whether Pressure‐Strain Product (PSP), a novel speckle‐tracking echocardiography parameter, (1) can correlate with pressure‐volume catheter‐based LVSWI and CPI, and (2) can be load‐independent during the flow modification of V‐A ECMO. Methods: Nine Dorset‐cross ewes (51 ± 4 kg) were included. After cardiogenic shock was induced, full support V‐A ECMO (X L/min based on 60 mL/kg/min) commenced. At seven time points during 24‐h observation, echocardiographic parameters as well as pressure‐volume catheter‐based LVSWI and CPI were simultaneously measured with X and following X‐1 L/min of ECMO flow. PSP was calculated by multiplying global circumferential strain or global radial strain, and mean arterial pressure, for PSPcirc or PSPrad, respectively. Results: PSPcirc showed a stronger correlation with LVSWI (correlation coefficient, CC =.360, p <.001) and CPI (CC =.283, p <.001) than other echocardiographic parameters. The predictability of PSPcirc for pressure‐volume catheter‐based LVSWI (AUC.82) and CPI (AUC.80) was also higher than other echocardiographic parameters. No statistically significant differences were identified between the two ECMO flow variations in PSPcirc (p =.558). Conclusions: A novel echocardiographic parameter, PSP, may non‐invasively predict pressure‐volume catheter‐based LVSWI and CPI in a load‐independent manner in a cardiogenic shock supported by V‐A ECMO. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Door‐to‐Needle Time for Extracorporeal Cardiopulmonary Resuscitation and Neurological Outcomes in Out‐of‐Hospital Cardiac Arrest: A Nationwide Study

Author

Yamamoto, Ryo, primary, Kaito, Daiki, additional, Homma, Koichiro, additional, Inoue, Akihiko, additional, Hifumi, Toru, additional, Sakamoto, Tetsuya, additional, Kuroda, Yasuhiro, additional, Sasaki, Junichi, additional, Sawano, Hirotaka, additional, Egawa, Yuko, additional, Kato, Shunichi, additional, Bunya, Naofumi, additional, Kasai, Takehiko, additional, Ijuin, Shinichi, additional, Nakayama, Shinichi, additional, Kanda, Jun, additional, Kanou, Seiya, additional, Takiguchi, Toru, additional, Yokobori, Shoji, additional, Takada, Hiroaki, additional, Inoue, Kazushige, additional, Takeuchi, Ichiro, additional, Honzawa, Hiroshi, additional, Kobayashi, Makoto, additional, Hamagami, Tomohiro, additional, Takayama, Wataru, additional, Otomo, Yasuhiro, additional, Maekawa, Kunihiko, additional, Shimizu, Takafumi, additional, Nara, Satoshi, additional, Nasu, Michitaka, additional, Takahashi, Kuniko, additional, Hagiwara, Yoshihiro, additional, Kushimoto, Shigeki, additional, Fukuda, Reo, additional, Ogura, Takayuki, additional, Shiraishi, Shin‐ichiro, additional, Zushi, Ryosuke, additional, Otani, Norio, additional, Kikuchi, Migaku, additional, Watanabe, Kazuhiro, additional, Nakagami, Takuo, additional, Shoko, Tomohisa, additional, Kitamura, Nobuya, additional, Otani, Takayuki, additional, Matsuoka, Yoshinori, additional, Aoki, Makoto, additional, Sakuraya, Masaaki, additional, Arimoto, Hideki, additional, Naito, Hiromichi, additional, Nakao, Shunichiro, additional, Okazaki, Tomoya, additional, Tahara, Yoshio, additional, Okamoto, Hiroshi, additional, Kunikata, Jun, additional, and Yokoi, Hideto, additional

Published
2024
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18. Fibrinogen levels and bleeding risk in adult extracorporeal cardiopulmonary resuscitation: multicenter observational study subanalysis

Author

Sawano, Hirotaka, Egawa, Yuko, Kato, Shunichi, Bunya, Naofumi, Kasai, Takehiko, Ijuin, Shinichi, Nakayama, Shinichi, Kanda, Jun, Takiguchi, Toru, Yokobori, Shoji, Takada, Hiroaki, Inoue, Kazushige, Takeuchi, Ichiro, Honzawa, Hiroshi, Kobayashi, Makoto, Hamagami, Tomohiro, Takayama, Wataru, Otomo, Yasuhiro, Maekawa, Kunihiko, Shimizu, Takafumi, Nara, Satoshi, Nasu, Michitaka, Takahashi, Kuniko, Hagiwara, Yoshihiro, Kushimoto, Shigeki, Fukuda, Reo, Ogura, Takayuki, Shiraishi, Shin-ichiro, Zushi, Ryosuke, Otani, Norio, Kikuchi, Migaku, Watanabe, Kazuhiro, Nakagami, Takuo, Shoko, Tomohisa, Kitamura, Nobuya, Otani, Takayuki, Matsuoka, Yoshinori, Aoki, Makoto, Sakuraya, Masaaki, Arimoto, Hideki, Homma, Koichiro, Naito, Hiromichi, Nakao, Shunichiro, Okazaki, Tomoya, Tahara, Yoshio, Okamoto, Hiroshi, Kunikata, Jun, Yokoi, Hideto, Kanou, Seiya, Nakatani, Eiji, Urano, Tetsumei, Sasaki, Hatoko, Inoue, Akihiko, Hifumi, Toru, Sakamoto, Tetsuya, Kuroda, Yasuhiro, and Tanaka, Yoshihiro

Published
2025
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23. Etiology-Based Prognosis of Extracorporeal CPR Recipients After Out-of-Hospital Cardiac Arrest

Author

Takiguchi, Toru, primary, Tominaga, Naoki, additional, Hamaguchi, Takuro, additional, Seki, Tomohisa, additional, Nakata, Jun, additional, Yamamoto, Takeshi, additional, Tagami, Takashi, additional, Inoue, Akihiko, additional, Hifumi, Toru, additional, Sakamoto, Tetsuya, additional, Kuroda, Yasuhiro, additional, Yokobori, Shoji, additional, Sawano, Hirotaka, additional, Egawa, Yuko, additional, Kato, Shunichi, additional, Bunya, Naofumi, additional, Kasai, Takehiko, additional, Ijuin, Shinichi, additional, Nakayama, Shinichi, additional, Kanda, Jun, additional, Kanou, Seiya, additional, Takada, Hiroaki, additional, Inoue, Kazushige, additional, Takeuchi, Ichiro, additional, Honzawa, Hiroshi, additional, Kobayashi, Makoto, additional, Hamagami, Tomohiro, additional, Takayama, Wataru, additional, Otomo, Yasuhiro, additional, Maekawa, Kunihiko, additional, Shimizu, Takafumi, additional, Nara, Satoshi, additional, Nasu, Michitaka, additional, Takahashi, Kuniko, additional, Hagiwara, Yoshihiro, additional, Kushimoto, Shigeki, additional, Fukuda, Reo, additional, Ogura, Takayuki, additional, Shiraishi, Shin-ichiro, additional, Zushi, Ryosuke, additional, Otani, Norio, additional, Kikuchi, Migaku, additional, Watanabe, Kazuhiro, additional, Nakagami, Takuo, additional, Shoko, Tomohisa, additional, Kitamura, Nobuya, additional, Otani, Takayuki, additional, Matsuoka, Yoshinori, additional, Aoki, Makoto, additional, Sakuraya, Masaaki, additional, Arimoto, Hideki, additional, Homma, Koichiro, additional, Naito, Hiromichi, additional, Nakao, Shunichiro, additional, Okazaki, Tomoya, additional, Tahara, Yoshio, additional, Okamoto, Hiroshi, additional, Kunikata, Jun, additional, and Yokoi, Hideto, additional

Published
2023
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24. Low-flow time and outcomes in hypothermic cardiac arrest patients treated with extracorporeal cardiopulmonary resuscitation: a secondary analysis of a multi-center retrospective cohort study.

Author

Shoji, Kosuke, Ohbe, Hiroyuki, Matsuyama, Tasuku, Inoue, Akihiko, Hifumi, Toru, Sakamoto, Tetsuya, Kuroda, Yasuhiro, Kushimoto, Shigeki, Sawano, Hirotaka, Egawa, Yuko, Kato, Shunichi, Sugiyama, Kazuhiro, Bunya, Naofumi, Kasai, Takehiko, Ijuin, Shinichi, Nakayama, Shinichi, Kanda, Jun, Kanou, Seiya, Takiguchi, Toru, and Yokobori, Shoji

Subjects
CARDIOPULMONARY resuscitation, CARDIAC arrest, CARDIAC patients, SECONDARY analysis, COHORT analysis
Abstract

Background: In out-of-hospital cardiac arrest (OHCA) patients with extracorporeal cardiopulmonary resuscitation (ECPR), the association between low-flow time and outcomes in accidental hypothermia (AH) patients compared to those of patients without AH has not been fully investigated. Methods: This was a secondary analysis of the retrospective multicenter registry in Japan. We enrolled patients aged ≥ 18 years who had been admitted to the emergency department for OHCA and had undergone ECPR between January, 2013 and December, 2018. AH was defined as an arrival body temperature below 32 °C. The primary outcome was survival to discharge. Cubic spline analyses were performed to assess the non-linear associations between low-flow time and outcomes stratified by the presence of AH. We also analyzed the interaction between low-flow time and the presence of AH. Results: Of 1252 eligible patients, 105 (8.4%) and 1147 (91.6%) were in the AH and non-AH groups, respectively. Median low-flow time was 60 (47–79) min in the AH group and 51 (42–62) min in the non-AH group. The survival discharge rates in the AH and non-AH groups were 44.8% and 25.4%, respectively. The cubic spline analyses showed that survival discharge rate remained constant regardless of low-flow time in the AH group. Conversely, a decreasing trend was identified in the survival discharge rate with longer low-flow time in the non-AH group. The interaction analysis revealed a significant interaction between low-flow time and AH in survival discharge rate (p for interaction = 0.048). Conclusions: OHCA patients with arrival body temperature < 32 °C who had received ECPR had relatively good survival outcomes regardless of low-flow time, in contrast to those of patients without AH. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Impact of center volume on in-hospital mortality in adult patients with out‑of‑hospital cardiac arrest resuscitated using extracorporeal cardiopulmonary resuscitation: a secondary analysis of the SAVE-J II study.

Author

Misumi, Kayo, Hagiwara, Yoshihiro, Kimura, Takuya, Hifumi, Toru, Inoue, Akihiko, Sakamoto, Tetsuya, Kuroda, Yasuhiro, Ogura, Takayuki, Sawano, Hirotaka, Egawa, Yuko, Kato, Shunichi, Sugiyama, Kazuhiro, Bunya, Naofumi, Kasai, Takehiko, Ijuin, Shinichi, Nakayama, Shinichi, Kanda, Jun, Kanou, Seiya, Takiguchi, Toru, and Yokobori, Shoji

Subjects
CARDIOPULMONARY resuscitation, CARDIAC arrest, HOSPITAL mortality, SECONDARY analysis, CARDIAC patients, AUTOMATED external defibrillation
Abstract

Recently, patients with out-of-hospital cardiac arrest (OHCA) refractory to conventional resuscitation have started undergoing extracorporeal cardiopulmonary resuscitation (ECPR). However, the mortality rate of these patients remains high. This study aimed to clarify whether a center ECPR volume was associated with the survival rates of adult patients with OHCA resuscitated using ECPR. This was a secondary analysis of a retrospective multicenter registry study, the SAVE-J II study, involving 36 participating institutions in Japan. Centers were divided into three groups according to the tertiles of the annual average number of patients undergoing ECPR: high-volume (≥ 21 sessions per year), medium-volume (11–20 sessions per year), or low-volume (< 11 sessions per year). The primary outcome was survival rate at the time of discharge. Patient characteristics and outcomes were compared among the three groups. Moreover, a multivariable-adjusted logistic regression model was applied to study the impact of center ECPR volume. A total of 1740 patients were included in this study. The center ECPR volume was strongly associated with survival rate at the time of discharge; furthermore, survival rate was best in high-volume compared with medium- and low-volume centers (33.4%, 24.1%, and 26.8%, respectively; P = 0.001). After adjusting for patient characteristics, undergoing ECPR at high-volume centers was associated with an increased likelihood of survival compared to middle- (adjusted odds ratio 0.657; P = 0.003) and low-volume centers (adjusted odds ratio 0.983; P = 0.006). The annual number of ECPR sessions was associated with favorable survival rates and lower complication rates of the ECPR procedure. Clinical trial registration: https://center6.umin.ac.jp/cgi-open-bin/ctr%5fe/ctr%5fview.cgi?recptno=R000041577 (unique identifier: UMIN000036490). [ABSTRACT FROM AUTHOR]

Published
2024
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26. Etiology-Based Prognosis of Extracorporeal CPR Recipients After Out-of-Hospital Cardiac Arrest

Author

Takiguchi, Toru, Tominaga, Naoki, Hamaguchi, Takuro, Seki, Tomohisa, Nakata, Jun, Yamamoto, Takeshi, Tagami, Takashi, Inoue, Akihiko, Hifumi, Toru, Sakamoto, Tetsuya, Kuroda, Yasuhiro, Yokobori, Shoji, Sawano, Hirotaka, Egawa, Yuko, Kato, Shunichi, Bunya, Naofumi, Kasai, Takehiko, Ijuin, Shinichi, Nakayama, Shinichi, Kanda, Jun, Kanou, Seiya, Takada, Hiroaki, Inoue, Kazushige, Takeuchi, Ichiro, Honzawa, Hiroshi, Kobayashi, Makoto, Hamagami, Tomohiro, Takayama, Wataru, Otomo, Yasuhiro, Maekawa, Kunihiko, Shimizu, Takafumi, Nara, Satoshi, Nasu, Michitaka, Takahashi, Kuniko, Hagiwara, Yoshihiro, Kushimoto, Shigeki, Fukuda, Reo, Ogura, Takayuki, Shiraishi, Shin-ichiro, Zushi, Ryosuke, Otani, Norio, Kikuchi, Migaku, Watanabe, Kazuhiro, Nakagami, Takuo, Shoko, Tomohisa, Kitamura, Nobuya, Otani, Takayuki, Matsuoka, Yoshinori, Aoki, Makoto, Sakuraya, Masaaki, Arimoto, Hideki, Homma, Koichiro, Naito, Hiromichi, Nakao, Shunichiro, Okazaki, Tomoya, Tahara, Yoshio, Okamoto, Hiroshi, Kunikata, Jun, and Yokoi, Hideto

Abstract

A better understanding of the relative contributions of various factors to patient outcomes is essential for optimal patient selection for extracorporeal CPR (ECPR) therapy for patients with out-of-hospital cardiac arrest (OHCA). However, evidence on the prognostic comparison based on the etiologies of cardiac arrest is limited.

Published
2024
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27. The association between blood glucose levels on arrival at the hospital and patient outcomes after out-of-hospital cardiac arrest: A multicenter cohort study.

Author

Taira, Takuya, Inoue, Akihiko, Kuroda, Yasuhiro, Oosuki, Gentoku, Suga, Masafumi, Nishimura, Takeshi, Ijuin, Shinichi, and Ishihara, Satoshi

Abstract

This study aimed to investigate the association between blood glucose levels on arrival at the hospital and 1-month survival and favorable neurological outcomes in patients with OHCA using a large Japanese dataset. This study was a secondary analysis of data from the JAAM-OHCA Registry. Adult (≥18 years) patients with witnessed OHCA transported to emergency departments and registered in the database from June 2014 to December 2019 were included in the study. The primary and secondary endpoints were 1-month survival and 1-month favorable neurological outcomes (Glasgow-Pittsburgh Cerebral Performance Category score 1 or 2), respectively. Patients were categorized into the following four groups based on blood glucose levels on arrival at the hospital: <80 mg/dL, 80–179 mg/dL, 180–299 mg/dL, and ≥300 mg/dL. This study included 11,387 patients. Survival rates were 1.3%, 3.1%, 7.0%, and 5.7% in the <80 mg/dL, 80–179 mg/dL, 180–299 mg/dL, and ≥ 300 mg/dL blood glucose groups, respectively. The rates of favorable neurological outcomes in each group were 0.4%, 1.5%, 3.3%, and 2.5%, respectively. Multivariable analysis showed that 180–299 mg/dL glucose was significantly associated with 1-month survival and favorable neurological outcomes compared with 80–179 mg/dL glucose (odds ratio [OR], 1.77; 95% confidence interval [CI], 1.34–2.31; p < 0.001 and OR, 1.52; 95 % Cl, 1.02–2.25; p = 0.035, respectively). In this study, blood glucose levels with the best outcomes likely ranged from 200 to 250 mg/dL based on the cubic spline regression model. Blood glucose level of 180–299 mg/dL on arrival at the hospital was significantly associated with 1-month survival and favorable neurological outcomes compared to blood glucose level of 80–179 mg/dL in patients with OHCA. • The association between blood glucose levels and outcomes in OHCA patients has not been thoroughly examined. • Mild-to-moderate hyperglycemia on arrival at the hospital was significantly associated with 1-month good outcomes. • Blood glucose levels with the best outcomes likely ranged from 200 to 250 mg/dL based on the cubic spline regression model. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Association between PaCO2 and outcomes in patients who underwent extracorporeal cardiopulmonary resuscitation for out‐of‐hospital cardiac arrest.

Author

Kawakami, Ayumi, Shibahashi, Keita, Sugiyama, Kazuhiro, Hifumi, Toru, Inoue, Akihiko, Sakamoto, Tetsuya, Kuroda, Yasuhiro, Sawano, Hirotaka, Egawa, Yuko, Kato, Shunichi, Tanabe, Maki, Bunya, Naofumi, Kasai, Takehiko, Ijuin, Shinichi, Nakayama, Shinichi, Kanda, Jun, Kanou, Seiya, Takiguchi, Toru, Yokobori, Shoji, and Takada, Hiroaki

Published
2024
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29. Assessment and diagnosis of right ventricular failure—retrospection and future directions

Author

Ro, Sun Kyun, primary, Sato, Kei, additional, Ijuin, Shinichi, additional, Sela, Declan, additional, Fior, Gabriele, additional, Heinsar, Silver, additional, Kim, Ji Young, additional, Chan, Jonathan, additional, Nonaka, Hideaki, additional, Lin, Aaron C. W., additional, Bassi, Gianluigi Li, additional, Platts, David G., additional, Obonyo, Nchafatso G., additional, Suen, Jacky Y., additional, and Fraser, John F., additional

Published
2023
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31. A NOVEL SPECKLE-TRACKING ECHOCARDIOGRAPHIC PARAMETER CONSIDERING LEFT VENTRICULAR LOADING CONDITION IN CARDIOGENIC SHOCK DURING VA ECMO

Author

Sato, Kei, primary, Heinsar, Silver, additional, Wildi, Karin Susanne, additional, Obonyo, Nchafatso, additional, LIU, KEIBUN, additional, Farah, Samia, additional, Ainola, Carmen, additional, Sato, Noriko, additional, Fior, Gabriele, additional, Ro, Sun Kyun, additional, Gandini, Lucia, additional, Ijuin, Shinichi, additional, Bouquet, Mahe, additional, Wilson, Emily, additional, Passmore, Margaret, additional, Hyslop, Kieran, additional, Chan, Jonathan H., additional, Platts, David, additional, Suen, Jacky, additional, Bassi, Gianluigi Li, additional, and Fraser, John, additional

Published
2023
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33. Transient return of spontaneous circulation related to favourable outcomes in out-of-hospital cardiac arrest patients resuscitated with extracorporeal cardiopulmonary resuscitation: A secondary analysis of the SAVE-J II study

Author

Otani, Takayuki, primary, Hifumi, Toru, additional, Inoue, Akihiko, additional, Abe, Toshikazu, additional, Sakamoto, Tetsuya, additional, Kuroda, Yasuhiro, additional, Sawano, Hirotaka, additional, Egawa, Yuko, additional, Sugiyama, Kazuhiro, additional, Tanabe, Maki, additional, Bunya, Naofumi, additional, Kasai, Takehiko, additional, Ijuin, Shinichi, additional, Nakayama, Shinichi, additional, Kanda, Jun, additional, Kanou, Seiya, additional, Takiguchi, Toru, additional, Yokobori, Shoji, additional, Takada, Hiroaki, additional, Inoue, Kazushige, additional, Takeuchi, Ichiro, additional, Honzawa, Hiroshi, additional, Kobayashi, Makoto, additional, Hamagami, Tomohiro, additional, Takayama, Wataru, additional, Otomo, Yasuhiro, additional, Maekawa, Kunihiko, additional, Shimizu, Takafumi, additional, Nara, Satoshi, additional, Nasu, Michitaka, additional, Takahashi, Kuniko, additional, Hagiwara, Yoshihiro, additional, Kushimoto, Shigeki, additional, Fukuda, Reo, additional, Ogura, Takayuki, additional, Shiraishi, Shin-ichiro, additional, Zushi, Ryosuke, additional, Otani, Norio, additional, Kikuchi, Migaku, additional, Watanabe, Kazuhiro, additional, Nakagami, Takuo, additional, Shoko, Tomohisa, additional, Kitamura, Nobuya, additional, Otani, Takayuki, additional, Matsuoka, Yoshinori, additional, Aoki, Makoto, additional, Sakuraya, Masaaki, additional, Arimoto, Hideki, additional, Homma, Koichiro, additional, Naito, Hiromichi, additional, Nakao, Shunichiro, additional, Okazaki, Tomoya, additional, Tahara, Yoshio, additional, Okamoto, Hiroshi, additional, Kunikata, Jun, additional, and Yokoi, Hideto, additional

Published
2022
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37. Association between stress hyperglycemia on admission and unfavorable neurological outcome in OHCA patients receiving ECPR

Author

Taira, Takuya, primary, Inoue, Akihiko, additional, Nishimura, Takeshi, additional, Takahashi, Ryo, additional, Isobe, Maho, additional, Maemura, Saki, additional, Suga, Masafumi, additional, Ijuin, Shinichi, additional, Masano, Tomoya, additional, Matsuyama, Shigenari, additional, Ishihara, Satoshi, additional, Kuroda, Yasuhiro, additional, and Nakayama, Shinichi, additional

Published
2022
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38. Additional file 1 of Extracorporeal cardiopulmonary resuscitation in adult patients with out-of-hospital cardiac arrest: a retrospective large cohort multicenter study in Japan

Author

Inoue, Akihiko, Hifumi, Toru, Sakamoto, Tetsuya, Okamoto, Hiroshi, Kunikata, Jun, Yokoi, Hideto, Sawano, Hirotaka, Egawa, Yuko, Kato, Shunichi, Sugiyama, Kazuhiro, Bunya, Naofumi, Kasai, Takehiko, Ijuin, Shinichi, Nakayama, Shinichi, Kanda, Jun, Kanou, Seiya, Takiguchi, Toru, Yokobori, Shoji, Takada, Hiroaki, Inoue, Kazushige, Takeuchi, Ichiro, Honzawa, Hiroshi, Kobayashi, Makoto, Hamagami, Tomohiro, Takayama, Wataru, Otomo, Yasuhiro, Maekawa, Kunihiko, Shimizu, Takafumi, Nara, Satoshi, Nasu, Michitaka, Takahashi, Kuniko, Hagiwara, Yoshihiro, Kushimoto, Shigeki, Fukuda, Reo, Ogura, Takayuki, Shiraishi, Shin-ichiro, Zushi, Ryosuke, Otani, Norio, Kikuchi, Migaku, Watanabe, Kazuhiro, Nakagami, Takuo, Shoko, Tomohisa, Kitamura, Nobuya, Otani, Takayuki, Matsuoka, Yoshinori, Aoki, Makoto, Sakuraya, Masaaki, Arimoto, Hideki, Homma, Koichiro, Naito, Hiromichi, Nakao, Shunichiro, Okazaki, Tomoya, Tahara, Yoshio, and Kuroda, Yasuhiro

Abstract

Additional file 1: Fig. S1 Distribution of participating institutions in SAVE-J II. Fig. S2 Distribution of participating institutions and ECPR From 6 to 135 cases. Fig. S3 Distribution of age and estimated low flow time. Fig. S4 ECPR cases and neurological outcome and survival to hospital discharge, 2013–2018. Fig. S5 Association between age or estimated low flow time and complications. Table S1. Baseline characteristics according to neurological outcome at hospital discharge (N = 1644). Table S2. Baseline characteristics according to survival to hospital discharge (N = 1644). Table S3. Complications during ECPR according to neurological outcomes and survival to hospital discharge (N = 1644). Table S4. Baseline characteristics between initial cardiac rhythm at the scene (N = 1628). Table S5. Outcome data and complications during ECPR between initial cardiac rhythm at the scene (N = 1628). Table S6. ECMO information

Published
2022
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42. Details of Targeted Temperature Management Methods for Patients Who Had Out-of-Hospital Cardiac Arrest Receiving Extracorporeal Cardiopulmonary Resuscitation: A Questionnaire Survey.

Author

Hifumi, Toru, Inoue, Akihiko, Otani, Takayuki, Otani, Norio, Kushimoto, Shigeki, Sakamoto, Tetsuya, Kuroda, Yasuhiro, Takiguchi, Toru, Watanabe, Kazuhiro, Ogura, Takayuki, Okazaki, Tomoya, Ijuin, Shinichi, Zushi, Ryosuke, Arimoto, Hideki, Takada, Hiroaki, Shiraishi, Shin-ichiro, Egawa, Yuko, Kanda, Jun, Nasu, Michitaka, and Kobayashi, Makoto

Published
2022
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43. Rescue Pericardial Drainage and Return Connected to ECMO for Aortic Rupture into the Pericardial Sac with Acute Type A Aortic Dissection

Author

Ijuin, Shinichi, primary, Takeuchi, Mariko, additional, Nakai, Chikashi, additional, Inoue, Akihiko, additional, Izumi, So, additional, Igarashi, Nobuaki, additional, Matsuyama, Shigenari, additional, Ishihara, Satoshi, additional, Doi, Tomofumi, additional, Nakayama, Shinichi, additional, and Tsukube, Takuro, additional

Published
2021
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44. Successful interhospital transfer for extracorporeal cardiopulmonary resuscitation of a patient who had a cardiac arrest after cesarean section

Author

Ijuin, Shinichi, primary, Ishihara, Satoshi, additional, Maemura, Saki, additional, Fukushima, Masafumi, additional, Murakami, Atsushi, additional, Inoue, Akihiko, additional, Taniguchi, Yayoi, additional, Igarashi, Nobuaki, additional, Matsuyama, Shigenari, additional, Kawase, Tetsunori, additional, Doi, Tomofumi, additional, and Nakayama, Shinichi, additional

Published
2021
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