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The purpose of the study aimed to explore integrated active learning (IAL) practices in a graduate-level fully online, accelerated course at an HSI, with a focus on students' perceptions, and to evaluate the implementation of integrated active learning based on student feedback and reflections. Course instructors started implementing IAL practices for the same course in 2022. Data from before and after IAL implementation in terms of course syllabi and course designs on Blackboard, the LMS used in the HSI, were collected. To investigate students' perceptions, survey methods were also conducted. Findings revealed that graduate students overwhelmingly preferred IAL over traditional online learning approaches. Implications and recommendations were discussed. [ABSTRACT FROM AUTHOR]

AbstractContext Gallbladder cancer (GBC) is the most common malignant tumour of the biliary tract. Isoalantolactone (IAL), an active sesquiterpene lactone compound isolated from the roots of Inula helenium L. (Asteraceae), has antitumour effects.Objective This study investigates the effects of IAL on GBC.Materials and methods In vitro, NOZ and GBC-SD cells were treated with IAL (0, 10, 20 and 40 μM) for 24 h. The DMSO-treated cells were selected as a control. Cell proliferation, migration, invasion and apoptosis were measured by the CCK-8 assay, transwell assay, flow cytometry and western blot. In vivo, subcutaneous tumour xenografts were constructed by injecting nude mice (BALB/C) with 5 × 106 NOZ cells. Mice were divided into the control group (equal amount of DMSO), the IAL group (10 mg/kg/day) and the IAL + Ro 67-7476 group (IAL, 10 mg/kg/day; Ro 67-7476, 4 mg/kg/day). The study duration was 30 days.Results Compared with the DMSO group, cell proliferation of NOZ (IC50 15.98 μM) and GBC-SD (IC50 20.22 μM) was inhibited by about 70% in the IAL 40 μM group. Migration and invasion were suppressed by about 80%. Cell apoptosis rate was increased about three-fold. The phosphorylation level of ERK was decreased to 30–35%. Tumour volume and weight (about 80% reduction) were suppressed by IAL in vivo. Moreover, the effects of IAL were abolished by Ro 67-7476 in vitro and in vivo.Discussion and conclusions Our findings indicate that IAL could inhibit GBC progression in vitro and in vivo by inhibiting the ERK signalling pathway.

Gallbladder cancer (GBC) is the most common malignant tumour of the biliary tract. Isoalantolactone (IAL), an active sesquiterpene lactone compound isolated from the roots of Inula helenium L. (Asteraceae), has antitumour effects. This study investigates the effects of IAL on GBC. In vitro, NOZ and GBC-SD cells were treated with IAL (0, 10, 20 and 40 μM) for 24 h. The DMSO-treated cells were selected as a control. Cell proliferation, migration, invasion and apoptosis were measured by the CCK-8 assay, transwell assay, flow cytometry and western blot. In vivo, subcutaneous tumour xenografts were constructed by injecting nude mice (BALB/C) with 5 × 106 NOZ cells. Mice were divided into the control group (equal amount of DMSO), the IAL group (10 mg/kg/day) and the IAL + Ro 67-7476 group (IAL, 10 mg/kg/day; Ro 67-7476, 4 mg/kg/day). The study duration was 30 days. Compared with the DMSO group, cell proliferation of NOZ (IC50 15.98 μM) and GBC-SD (IC50 20.22 μM) was inhibited by about 70% in the IAL 40 μM group. Migration and invasion were suppressed by about 80%. Cell apoptosis rate was increased about three-fold. The phosphorylation level of ERK was decreased to 30–35%. Tumour volume and weight (about 80% reduction) were suppressed by IAL in vivo. Moreover, the effects of IAL were abolished by Ro 67-7476 in vitro and in vivo. Our findings indicate that IAL could inhibit GBC progression in vitro and in vivo by inhibiting the ERK signalling pathway. [ABSTRACT FROM AUTHOR]

Uno de los problemas constantes en la mejora de la evaluación de los sistemas de gestión de calidad, está relacionado con minimizar la subjetividad e incrementar los criterios de valoración. La presente investigación tuvo como objetivo proponer un procedimiento de cálculo y análisis para la evaluación del desempeño de los sistemas de gestión de calidad, orientado a reducir la subjetividad en la valoración del nivel de eficacia del sistema, según norma ISO 9000, a través del análisis de la literatura. Con este propósito, se correlacionaron los principios básicos de la gestión de calidad con indicadores de la entidad, utilizando el método de expertos para conformar una base de cálculo. El resultado obtenido fue un indicador del desempeño del sistema de gestión de calidad (EDsgc) de la organización; que, de acuerdo a los resultados del sistema, identifica la organización como: Principiante, Proactiva, Flexible, Innovadora o Sostenible. El procedimiento minimiza la subjetividad del resultado con el uso de escalas numéricas en cada indicador.

Epidemiological data have linked birth control formulations to an increased risk of infant acute leukemia involving MLL rearrangements. Reverse transcription polymerase chain reaction (RT-PCR) studies showed that 10 nM estradiol enhanced MLL transcription in addition to its common translocation partners, MLLT2 ( AF4) and MLLT3 ( AF9). The same concentration of estradiol triggered MLL and MLLT3 co-localization without affecting the interaction of genes located on the same chromosomes. Estradiol also stimulated the generation of MLL- MLLT3 fusion transcripts as seen by RT-PCR. RNAi knockdown of activation-induced cytidine deaminase (AICDA) suppressed the induction of MLL- MLLT3 fusion transcript formation observed with estradiol. Additionally, chromatin immunoprecipitation (ChIP) analysis showed estradiol dependent localization of AICDA in MLL intron 11, upstream of a hotspot for both DNA cleavage and rearrangement, but not downstream within intron 12. Combined, these studies show that levels of estradiol consistent with that observed during pregnancy have the potential to initiate MLL fusions through an AICDA-mediated mechanism. [ABSTRACT FROM AUTHOR]

The phrase "algorithmic language" is conspicuously associated with Algol, the acronym first used to name the programming language Algol 60, which originated through a cooperation between the ACM and German Association for Applied Mathematics and Mechanics (GAMM) groups of programming specialists. In the 1920s computing real things, solving messy equations, came to be called practical mathematics or numerical analysis, and the techniques to do so were called procedures, schemes, or Verfahren (in German). In the 1950s, however, the venerable notion of an "algorithm" allowed computer users, who were reflecting on developing computing procedures and transferring these to automatic machinery, describe what they thought they were "actually" doing. This article traces the use of the terms "algebraic" to "algorithmic" during the development of the programming language Algol. [ABSTRACT FROM PUBLISHER]