1. Neuropsychological functioning in MRI-derived subgroups of schizophrenia
- Author
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A. McGarrahan, Steven J. Kingsbury, I.J. Osuji, C. M. Cullum, Perry Mihalakos, and David L. Garver
- Subjects
Adult ,Male ,Psychosis ,Pediatrics ,medicine.medical_specialty ,Neuropsychological Tests ,Severity of Illness Index ,Cerebral Ventricles ,Severity of illness ,Neuropsychologia ,medicine ,Humans ,Biological Psychiatry ,Demography ,medicine.diagnostic_test ,Neuropsychology ,Brain ,Cognition ,Neuropsychological test ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Diagnostic and Statistical Manual of Mental Disorders ,Psychiatry and Mental health ,Schizophrenia ,Age of onset ,Cognition Disorders ,Psychology ,Clinical psychology - Abstract
This study examined neuropsychological functioning in two subgroups of patients with familial schizophrenia. Those who showed evidence of progressive ventricular enlargement observed across serial MRI scans (n=6) were compared with subjects whose ventricular volume remained static (n=10) over an average of 28 months. No differences were found in terms of age, education, ethnicity, level of psychotic symptomatology, DSM-IV subtype, age of onset, or duration of illness. Neurocognitively, the static ventricle group was impaired across more cognitive domains and had a larger percentage of subjects falling into the impaired range on a majority of measures, with the greatest differences on measures of attention (p
- Published
- 2007
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