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Purpose: to study influence of regional factors and intensive educational process on cardio-haemo-dynamic and vegetative characteristics in conditions of individual differentiated classes. Material: in the research 80 student (of 17-18 years’ age) participated; they were divided into group of the tested (n=40) and group of comparison (n=40). Results: we showed physiological influence on bloodstream regulation and weakening of activity in conditions of individual-differentiated classes. The content of programs of informational, sports-health related, physical culture and prophylaxis measures resulted in students’ different speed characteristics (in bloodstream links and in its regulation). In conditions of annual educational process the students had balance of sympathetic and para-sympathetic regulation of central and periphery bloodstream. It depends on weather factors of year seasons, on examination sessions. Conclusions: in conditions of educational process adaptation-compensatory shifts are conditioned by dominating segmental regulation with participation of bloodstream links and regulatory supra-segmental influences. We also observed manifestation of influence of separate autonomous regulation factors.