1. Concurrent Oral 9 - Rheumatoid Arthritis: Aetiopathogenesis [OP59-OP64]: OP59. The Value of Interleukin-17 Serum Level in Rheumatoid Arthritis Immunopathogenesis
- Author
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I. V. Biliavska, O. P. Bortkevych, S. Ceeraz, J. Spencer, E. H. Choy, V. Corrigall, M. Bombardieri, Y. Ngar Woon Kam, F. Brentano, K. Choi, D. Kyburz, S. Gay, I. B. McInnes, C. Pitzalis, L. L. Gompels, T. Vincent, L. Madden, N. H. Lim, E. McConnell, K. Mcnamee, D. O. Haskard, E. M. Paleolog, C. Swales, D. J. Mahoney, N. A. Athanasou, O. Sharif, A. J. Day, C. M. Milner, A. Sabokbar, H. Knowles, A.-M. Cleton-Jansen, E. Korsching, and N. Athanasou
- Subjects
biology ,business.industry ,medicine.medical_treatment ,Interleukin ,medicine.disease ,medicine.disease_cause ,Autoimmunity ,Cytokine ,Rheumatology ,Rheumatoid arthritis ,Immunology ,medicine ,biology.protein ,Rheumatoid factor ,Pharmacology (medical) ,Interleukin 17 ,Antibody ,business ,Cyclic Citrullinated Peptide Antibody - Abstract
Background: Interleukin (IL)-17 is the main Th-1 cytokine, produced by activated T-lymphocytes. The potential IL-17 value in rheumatoid arthritis (RA) pathogenesis consists of its independent inflammatory response induction and mediated stimulation of proinflammatory factors synthesis resulting in joint destruction. The aim of study was to determine the role of IL-17 in immuno-inflammatory/autoimmune reactions development and to reveal IL-17 serum level associations with clinical and immunological characteristics of RA. Methods: 50 patients with early RA (disease duration >, Russia), anti-CCP antibodies (Axies-Shield Diagnostic, UK) were revealed using ELISA immunoassay. Results: On the base of IL-17 serum level patients were divided in two groups: group1 (n = 28) were patients with normal IL-17 serum level and group2 (n = 22) were those with high IL-17 serum level. In the group2, the rate of patients' pain assessment by visual analogue scale (67.3 ± 7.2 vs 32.8 ± 4.6; P
- Published
- 2017