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3 results on '"I. Tamby"'

1. Antenatal diagnosis of congenital toxoplasmosis: evaluation of the biological parameters in a cohort of 286 patients

Author

E. Issert, J. Cazenave, J.-P. Dedet, F. Pratlong, I. Tamby, Pierre Boulot, and I. Villena

Subjects
medicine.medical_specialty, Amniotic fluid, Antibodies, Protozoan, Polymerase Chain Reaction, Toxoplasmosis, Congenital, Cohort Studies, Obstetrics and gynaecology, Pregnancy, Prenatal Diagnosis, Medicine, Animals, Humans, Lost to follow-up, Subclinical infection, Retrospective Studies, medicine.diagnostic_test, business.industry, Obstetrics, Obstetrics and Gynecology, Retrospective cohort study, DNA, Protozoan, medicine.disease, Fetal Blood, Toxoplasmosis, Surgery, Immunoglobulin A, Immunoglobulin M, Pregnancy Complications, Parasitic, Cohort, Amniocentesis, Female, business, Toxoplasma
Abstract

Objective To evaluate the biological parameters obtained by cordocentesis and amniocentesis in the antenatal diagnosis of congenital toxoplasmosis. Design Nine-year retrospective study. Setting Parasitology Laboratory, Department of Obstetrics and Gynaecology and Department of Paediatrics, Centre Hospitalo-Universitaire, Montpellier, France. Participants Two hundred and eighty-six pregnant women infected with toxoplasmosis between 7 and 34 weeks of gestation. Methods Detection of abnormalities by ultrasound examination. Detection in fetal blood of Toxoplasma, of specific IgM and IgA and of nonspecific biological markers. Detection in amniotic fluid of Toxoplasma. Results Out of 286 antenatal diagnoses, 211 were negative (1st group), 40 were positive (2nd group) and led to 8 medical abortions, and 35 were uncertain (3rd group). In the 1st and 3rd groups respectively, 7 (3.3 %) and 5 (14.3 %) cases of congenital toxoplasmosis were observed. Overall, 52 cases of congenital toxoplasmosis were detected : 12 were clinically apparent, 36 subclinical (of which 12 were in groups 1 and 3) and 4 were lost to follow up. Conclusion There is substantial importance in making the diagnosis of toxoplasmosis antenatally in order to limit the number of medical abortions. In our series, the most accurate predictor was the detection of the fetal antibody response (specific IgM and IgA) to Toxoplasma.

Published
1996

2. Polymerase chain reaction on sputum for the diagnosis of pulmonary toxoplasmosis in AIDS patients.

Author

Abraham B, Tamby I, Reynes J, and Bastien P

Subjects
AIDS-Related Opportunistic Infections parasitology, Adult, Animals, Humans, Lung Diseases, Parasitic parasitology, Male, Toxoplasma genetics, Toxoplasmosis parasitology, AIDS-Related Opportunistic Infections diagnosis, Lung Diseases, Parasitic diagnosis, Polymerase Chain Reaction methods, Sputum parasitology, Toxoplasma isolation & purification, Toxoplasmosis diagnosis
Published
2000
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3. Antenatal diagnosis of congenital toxoplasmosis: evaluation of the biological parameters in a cohort of 286 patients.

Author

Pratlong F, Boulot P, Villena I, Issert E, Tamby I, Cazenave J, and Dedet JP

Subjects
Animals, Antibodies, Protozoan blood, Cohort Studies, DNA, Protozoan isolation & purification, Female, Fetal Blood parasitology, Humans, Immunoglobulin A blood, Immunoglobulin M blood, Polymerase Chain Reaction, Pregnancy, Pregnancy Complications, Parasitic immunology, Retrospective Studies, Toxoplasma immunology, Toxoplasma isolation & purification, Toxoplasmosis, Congenital immunology, Pregnancy Complications, Parasitic diagnosis, Prenatal Diagnosis, Toxoplasmosis, Congenital diagnosis
Abstract

Objective: To evaluate the biological parameters obtained by cordocentesis and amniocentesis in the antenatal diagnosis of congenital toxoplasmosis., Design: Nine-year retrospective study., Setting: Parasitology Laboratory, Department of Obstetrics and Gynaecology and Department of Paediatrics, Centre Hospitalo-Universitaire, Montpellier, France., Participants: Two hundred and eighty-six pregnant women infected with toxoplasmosis between 7 and 34 weeks of gestation., Methods: Detection of abnormalities by ultrasound examination. Detection in fetal blood of Toxoplasma, of specific IgM and IgA and of nonspecific biological markers. Detection in amniotic fluid of Toxoplasma., Results: Out of 286 antenatal diagnoses, 211 were negative (1st group), 40 were positive (2nd group) and led to 8 medical abortions, and 35 were uncertain (3rd group). In the 1st and 3rd groups respectively, 7 (3.3%) and 5 (14.3%) cases of congenital toxoplasmosis were observed. Overall, 52 cases of congenital toxoplasmosis were detected: 12 were clinically apparent, 36 subclinical (of which 12 were in groups 1 and 3) and 4 were lost to follow up., Conclusion: There is substantial importance in making the diagnosis of toxoplasmosis antenatally in order to limit the number of medical abortions. In our series, the most accurate predictor was the detection of the fetal antibody response (specific IgM and IgA) to Toxoplasma.

Published
1996
Full Text
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