1. High cortisol responses identify propensity for obesity that is linked to thermogenesis in skeletal muscle
- Author
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Iain J. Clarke, I. Ross Young, Brian L. Leury, T. Kevin Lee, Alexandra Rao, Zane B. Andrews, Belinda A. Henry, and Justin C. St. John
- Subjects
Leptin ,Hypothalamo-Hypophyseal System ,medicine.medical_specialty ,Hydrocortisone ,Blotting, Western ,Pituitary-Adrenal System ,Real-Time Polymerase Chain Reaction ,Biochemistry ,Internal medicine ,Genetics ,medicine ,Animals ,Uncoupling protein ,Obesity ,Muscle, Skeletal ,Molecular Biology ,Sheep ,business.industry ,Body Weight ,Malignant hyperthermia ,Skeletal muscle ,Thermogenesis ,medicine.disease ,Endocrinology ,medicine.anatomical_structure ,Postprandial ,Body Composition ,Female ,Energy Metabolism ,business ,Hypothalamic–pituitary–adrenal axis ,Biotechnology ,medicine.drug - Abstract
Subjects characterized as cortisol high responders (HRs) consume more calories after stress, but it is unknown whether cortisol responsiveness predicts a propensity for obesity. Female sheep with either high or low cortisol responses to adrenocorticotropin (ACTH) were identified. Body composition was similar in HRs and cortisol low responders (LRs), but the HRs had greater (P
- Published
- 2013