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1. OPA1 and disease-causing mutants perturb mitochondrial nucleoid distribution

Author

J. Macuada, I. Molina-Riquelme, G. Vidal, N. Pérez-Bravo, C. Vásquez-Trincado, G. Aedo, D. Lagos, P. Yu-Wai-Man, R. Horvath, T. J. Rudge, B. Cartes-Saavedra, and V. Eisner

Subjects
Cytology, QH573-671
Abstract

Abstract Optic atrophy protein 1 (OPA1) mediates inner mitochondrial membrane (IMM) fusion and cristae organization. Mutations in OPA1 cause autosomal dominant optic atrophy (ADOA), a leading cause of blindness. Cells from ADOA patients show impaired mitochondrial fusion, cristae structure, bioenergetic function, and mitochondrial DNA (mtDNA) integrity. The mtDNA encodes electron transport chain subunits and is packaged into nucleoids spread within the mitochondrial population. Nucleoids interact with the IMM, and their distribution is tightly linked to mitochondrial fusion and cristae shaping. Yet, little is known about the physio-pathological relevance of nucleoid distribution. We studied the effect of OPA1 and ADOA-associated mutants on nucleoid distribution using high-resolution confocal microscopy. We applied a novel model incorporating the mitochondrial context, separating nucleoid distribution into the array in the mitochondrial population and intramitochondrial longitudinal distribution. Opa1-null cells showed decreased mtDNA levels and nucleoid abundance. Also, loss of Opa1 led to an altered distribution of nucleoids in the mitochondrial population, loss of cristae periodicity, and altered nucleoids to cristae proximity partly rescued by OPA1 isoform 1. Overexpression of WT OPA1 or ADOA-causing mutants c.870+5 G > A or c.2713 C > T in WT cells, showed perturbed nucleoid array in the mitochondria population associated with cristae disorganization, which was partly reproduced in Skeletal muscle-derived fibroblasts from ADOA patients harboring the same mutants. Opa1-null and cells overexpressing ADOA mutants accumulated mitochondria without nucleoids. Interestingly, intramitochondrial nucleoid distribution was only altered in Opa1-null cells. Altogether, our results highlight the relevance of OPA1 in nucleoid distribution in the mitochondrial landscape and at a single-organelle level and shed light on new components of ADOA etiology.

Published
2024
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2. Correction: Efficacy and safety assessment of different dosage of benznidazol for the treatment of Chagas disease in chronic phase in adults (MULTIBENZ study): study protocol for a multicenter randomized Phase II non-inferiority clinical trial

Author

D. Molina-Morant, M. L. Fernández, P. Bosch-Nicolau, E. Sulleiro, M. Bangher, F. Salvador, A. Sanchez-Montalva, A. L. P. Ribeiro, A. M. B. de Paula, S. Eloi, R. Correa-Oliveira, J. C. Villar, S. Sosa-Estani, and I. Molina

Subjects
Medicine (General), R5-920
Published
2023
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3. GWTC-3: Compact Binary Coalescences Observed by LIGO and Virgo during the Second Part of the Third Observing Run

Author

R. Abbott, T. D. Abbott, F. Acernese, K. Ackley, C. Adams, N. Adhikari, R. X. Adhikari, V. B. Adya, C. Affeldt, D. Agarwal, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, L. Aiello, A. Ain, P. Ajith, S. Akcay, T. Akutsu, S. Albanesi, A. Allocca, P. A. Altin, A. Amato, C. Anand, S. Anand, A. Ananyeva, S. B. Anderson, W. G. Anderson, M. Ando, T. Andrade, N. Andres, T. Andrić, S. V. Angelova, S. Ansoldi, J. M. Antelis, S. Antier, S. Appert, Koji Arai, Koya Arai, Y. Arai, S. Araki, A. Araya, M. C. Araya, J. S. Areeda, M. Arène, N. Aritomi, N. Arnaud, M. Arogeti, S. M. Aronson, K. G. Arun, H. Asada, Y. Asali, G. Ashton, Y. Aso, M. Assiduo, S. M. Aston, P. Astone, F. Aubin, C. Austin, S. Babak, F. Badaracco, M. K. M. Bader, C. Badger, S. Bae, Y. Bae, A. M. Baer, S. Bagnasco, Y. Bai, L. Baiotti, J. Baird, R. Bajpai, M. Ball, G. Ballardin, S. W. Ballmer, A. Balsamo, G. Baltus, S. Banagiri, D. Bankar, J. C. Barayoga, C. Barbieri, B. C. Barish, D. Barker, P. Barneo, F. Barone, B. Barr, L. Barsotti, M. Barsuglia, D. Barta, J. Bartlett, M. A. Barton, I. Bartos, R. Bassiri, A. Basti, M. Bawaj, J. C. Bayley, A. C. Baylor, M. Bazzan, B. Bécsy, V. M. Bedakihale, M. Bejger, I. Belahcene, V. Benedetto, D. Beniwal, T. F. Bennett, J. D. Bentley, M. BenYaala, F. Bergamin, B. K. Berger, S. Bernuzzi, C. P. L. Berry, D. Bersanetti, A. Bertolini, J. Betzwieser, D. Beveridge, R. Bhandare, U. Bhardwaj, D. Bhattacharjee, S. Bhaumik, I. A. Bilenko, G. Billingsley, S. Bini, R. Birney, O. Birnholtz, S. Biscans, M. Bischi, S. Biscoveanu, A. Bisht, B. Biswas, M. Bitossi, M.-A. Bizouard, J. K. Blackburn, C. D. Blair, D. G. Blair, R. M. Blair, F. Bobba, N. Bode, M. Boer, G. Bogaert, M. Boldrini, L. D. Bonavena, F. Bondu, E. Bonilla, R. Bonnand, P. Booker, B. A. Boom, R. Bork, V. Boschi, N. Bose, S. Bose, V. Bossilkov, V. Boudart, Y. Bouffanais, A. Bozzi, C. Bradaschia, P. R. Brady, A. Bramley, A. Branch, M. Branchesi, J. Brandt, J. E. Brau, M. Breschi, T. Briant, J. H. Briggs, A. Brillet, M. Brinkmann, P. Brockill, A. F. Brooks, J. Brooks, D. D. Brown, S. Brunett, G. Bruno, R. Bruntz, J. Bryant, T. Bulik, H. J. Bulten, A. Buonanno, R. Buscicchio, D. Buskulic, C. Buy, R. L. Byer, G. S. Cabourn Davies, L. Cadonati, G. Cagnoli, C. Cahillane, J. Calderón Bustillo, J. D. Callaghan, T. A. Callister, E. Calloni, J. Cameron, J. B. Camp, M. Canepa, S. Canevarolo, M. Cannavacciuolo, K. C. Cannon, H. Cao, Z. Cao, E. Capocasa, E. Capote, G. Carapella, F. Carbognani, J. B. Carlin, M. F. Carney, M. Carpinelli, G. Carrillo, G. Carullo, T. L. Carver, J. Casanueva Diaz, C. Casentini, G. Castaldi, S. Caudill, M. Cavaglià, F. Cavalier, R. Cavalieri, M. Ceasar, G. Cella, P. Cerdá-Durán, E. Cesarini, W. Chaibi, K. Chakravarti, S. Chalathadka Subrahmanya, E. Champion, C.-H. Chan, C. Chan, C. L. Chan, K. Chan, M. Chan, K. Chandra, P. Chanial, S. Chao, C. E. A. Chapman-Bird, P. Charlton, E. A. Chase, E. Chassande-Mottin, C. Chatterjee, Debarati Chatterjee, Deep Chatterjee, M. Chaturvedi, S. Chaty, K. Chatziioannou, C. Chen, H. Y. Chen, J. Chen, K. Chen, X. Chen, Y.-B. Chen, Y.-R. Chen, Z. Chen, H. Cheng, C. K. Cheong, H. Y. Cheung, H. Y. Chia, F. Chiadini, C-Y. Chiang, G. Chiarini, R. Chierici, A. Chincarini, M. L. Chiofalo, A. Chiummo, G. Cho, H. S. Cho, R. K. Choudhary, S. Choudhary, N. Christensen, H. Chu, Q. Chu, Y-K. Chu, S. Chua, K. W. Chung, G. Ciani, P. Ciecielag, M. Cieślar, M. Cifaldi, A. A. Ciobanu, R. Ciolfi, F. Cipriano, A. Cirone, F. Clara, E. N. Clark, J. A. Clark, L. Clarke, P. Clearwater, S. Clesse, F. Cleva, E. Coccia, E. Codazzo, P.-F. Cohadon, D. E. Cohen, L. Cohen, M. Colleoni, C. G. Collette, A. Colombo, M. Colpi, C. M. Compton, M. Constancio, Jr., L. Conti, S. J. Cooper, P. Corban, T. R. Corbitt, I. Cordero-Carrión, S. Corezzi, K. R. Corley, N. Cornish, D. Corre, A. Corsi, S. Cortese, C. A. Costa, R. Cotesta, M. W. Coughlin, J.-P. Coulon, S. T. Countryman, B. Cousins, P. Couvares, D. M. Coward, M. J. Cowart, D. C. Coyne, R. Coyne, J. D. E. Creighton, T. D. Creighton, A. W. Criswell, M. Croquette, S. G. Crowder, J. R. Cudell, T. J. Cullen, A. Cumming, R. Cummings, L. Cunningham, E. Cuoco, M. Curyło, P. Dabadie, T. Dal Canton, S. Dall’Osso, G. Dálya, A. Dana, L. M. DaneshgaranBajastani, B. D’Angelo, B. Danila, S. Danilishin, S. D’Antonio, K. Danzmann, C. Darsow-Fromm, A. Dasgupta, L. E. H. Datrier, V. Dattilo, I. Dave, M. Davier, D. Davis, M. C. Davis, E. J. Daw, P. F. de Alarcón, R. Dean, D. DeBra, M. Deenadayalan, J. Degallaix, M. De Laurentis, S. Deléglise, V. Del Favero, F. De Lillo, N. De Lillo, W. Del Pozzo, L. M. DeMarchi, F. De Matteis, V. D’Emilio, N. Demos, T. Dent, A. Depasse, R. De Pietri, R. De Rosa, C. De Rossi, R. DeSalvo, R. De Simone, S. Dhurandhar, M. C. Díaz, M. Diaz-Ortiz, Jr., N. A. Didio, T. Dietrich, L. Di Fiore, C. Di Fronzo, C. Di Giorgio, F. Di Giovanni, M. Di Giovanni, T. Di Girolamo, A. Di Lieto, B. Ding, S. Di Pace, I. Di Palma, F. Di Renzo, A. K. Divakarla, A. Dmitriev, Z. Doctor, L. D’Onofrio, F. Donovan, K. L. Dooley, S. Doravari, I. Dorrington, M. Drago, J. C. Driggers, Y. Drori, J.-G. Ducoin, P. Dupej, O. Durante, D. D’Urso, P.-A. Duverne, S. E. Dwyer, C. Eassa, P. J. Easter, M. Ebersold, T. Eckhardt, G. Eddolls, B. Edelman, T. B. Edo, O. Edy, A. Effler, S. Eguchi, J. Eichholz, S. S. Eikenberry, M. Eisenmann, R. A. Eisenstein, A. Ejlli, E. Engelby, Y. Enomoto, L. Errico, R. C. Essick, H. Estellés, D. Estevez, Z. Etienne, T. Etzel, M. Evans, T. M. Evans, B. E. Ewing, V. Fafone, H. Fair, S. Fairhurst, A. M. Farah, S. Farinon, B. Farr, W. M. Farr, N. W. Farrow, E. J. Fauchon-Jones, G. Favaro, M. Favata, M. Fays, M. Fazio, J. Feicht, M. M. Fejer, E. Fenyvesi, D. L. Ferguson, A. Fernandez-Galiana, I. Ferrante, T. A. Ferreira, F. Fidecaro, P. Figura, I. Fiori, M. Fishbach, R. P. Fisher, R. Fittipaldi, V. Fiumara, R. Flaminio, E. Floden, H. Fong, J. A. Font, B. Fornal, P. W. F. Forsyth, A. Franke, S. Frasca, F. Frasconi, C. Frederick, J. P. Freed, Z. Frei, A. Freise, R. Frey, P. Fritschel, V. V. Frolov, G. G. Fronzé, Y. Fujii, Y. Fujikawa, M. Fukunaga, M. Fukushima, P. Fulda, M. Fyffe, H. A. Gabbard, W. E. Gabella, B. U. Gadre, J. R. Gair, J. Gais, S. Galaudage, R. Gamba, D. Ganapathy, A. Ganguly, D. Gao, S. G. Gaonkar, B. Garaventa, F. García, C. García-Núñez, C. García-Quirós, F. Garufi, B. Gateley, S. Gaudio, V. Gayathri, G.-G. Ge, G. Gemme, A. Gennai, J. George, R. N. George, O. Gerberding, L. Gergely, P. Gewecke, S. Ghonge, Abhirup Ghosh, Archisman Ghosh, Shaon Ghosh, Shrobana Ghosh, B. Giacomazzo, L. Giacoppo, J. A. Giaime, K. D. Giardina, D. R. Gibson, C. Gier, M. Giesler, P. Giri, F. Gissi, J. Glanzer, A. E. Gleckl, P. Godwin, E. Goetz, R. Goetz, N. Gohlke, J. Golomb, B. Goncharov, G. González, A. Gopakumar, M. Gosselin, R. Gouaty, D. W. Gould, B. Grace, A. Grado, M. Granata, V. Granata, A. Grant, S. Gras, P. Grassia, C. Gray, R. Gray, G. Greco, A. C. Green, R. Green, A. M. Gretarsson, E. M. Gretarsson, D. Griffith, W. Griffiths, H. L. Griggs, G. Grignani, A. Grimaldi, S. J. Grimm, H. Grote, S. Grunewald, P. Gruning, D. Guerra, G. M. Guidi, A. R. Guimaraes, G. Guixé, H. K. Gulati, H.-K. Guo, Y. Guo, Anchal Gupta, Anuradha Gupta, P. Gupta, E. K. Gustafson, R. Gustafson, F. Guzman, S. Ha, L. Haegel, A. Hagiwara, S. Haino, O. Halim, E. D. Hall, E. Z. Hamilton, G. Hammond, W.-B. Han, M. Haney, J. Hanks, C. Hanna, M. D. Hannam, O. Hannuksela, H. Hansen, T. J. Hansen, J. Hanson, T. Harder, T. Hardwick, K. Haris, J. Harms, G. M. Harry, I. W. Harry, D. Hartwig, K. Hasegawa, B. Haskell, R. K. Hasskew, C.-J. Haster, K. Hattori, K. Haughian, H. Hayakawa, K. Hayama, F. J. Hayes, J. Healy, A. Heidmann, A. Heidt, M. C. Heintze, J. Heinze, J. Heinzel, H. Heitmann, F. Hellman, P. Hello, A. F. Helmling-Cornell, G. Hemming, M. Hendry, I. S. Heng, E. Hennes, J. Hennig, M. H. Hennig, A. G. Hernandez, F. Hernandez Vivanco, M. Heurs, S. Hild, P. Hill, Y. Himemoto, A. S. Hines, Y. Hiranuma, N. Hirata, E. Hirose, S. Hochheim, D. Hofman, J. N. Hohmann, D. G. Holcomb, N. A. Holland, K. Holley-Bockelmann, I. J. Hollows, Z. J. Holmes, K. Holt, D. E. Holz, Z. Hong, P. Hopkins, J. Hough, S. Hourihane, E. J. Howell, C. G. Hoy, D. Hoyland, A. Hreibi, B-H. Hsieh, Y. Hsu, G-Z. Huang, H-Y. Huang, P. Huang, Y-C. Huang, Y.-J. Huang, Y. Huang, M. T. Hübner, A. D. Huddart, B. Hughey, D. C. Y. Hui, V. Hui, S. Husa, S. H. Huttner, R. Huxford, T. Huynh-Dinh, S. Ide, B. Idzkowski, A. Iess, B. Ikenoue, S. Imam, K. Inayoshi, C. Ingram, Y. Inoue, K. Ioka, M. Isi, K. Isleif, K. Ito, Y. Itoh, B. R. Iyer, K. Izumi, V. JaberianHamedan, T. Jacqmin, S. J. Jadhav, S. P. Jadhav, A. L. James, A. Z. Jan, K. Jani, J. Janquart, K. Janssens, N. N. Janthalur, P. Jaranowski, D. Jariwala, R. Jaume, A. C. Jenkins, K. Jenner, C. Jeon, M. Jeunon, W. Jia, H.-B. Jin, G. R. Johns, N. K. Johnson-McDaniel, A. W. Jones, D. I. Jones, J. D. Jones, P. Jones, R. Jones, R. J. G. Jonker, L. Ju, P. Jung, K. Jung, J. Junker, V. Juste, K. Kaihotsu, T. Kajita, M. Kakizaki, C. V. Kalaghatgi, V. Kalogera, B. Kamai, M. Kamiizumi, N. Kanda, S. Kandhasamy, G. Kang, J. B. Kanner, Y. Kao, S. J. Kapadia, D. P. Kapasi, S. Karat, C. Karathanasis, S. Karki, R. Kashyap, M. Kasprzack, W. Kastaun, S. Katsanevas, E. Katsavounidis, W. Katzman, T. Kaur, K. Kawabe, K. Kawaguchi, N. Kawai, T. Kawasaki, F. Kéfélian, D. Keitel, J. S. Key, S. Khadka, F. Y. Khalili, S. Khan, E. A. Khazanov, N. Khetan, M. Khursheed, N. Kijbunchoo, C. Kim, J. C. Kim, J. Kim, K. Kim, W. S. Kim, Y.-M. Kim, C. Kimball, N. Kimura, M. Kinley-Hanlon, R. Kirchhoff, J. S. Kissel, N. Kita, H. Kitazawa, L. Kleybolte, S. Klimenko, A. M. Knee, T. D. Knowles, E. Knyazev, P. Koch, G. Koekoek, Y. Kojima, K. Kokeyama, S. Koley, P. Kolitsidou, M. Kolstein, K. Komori, V. Kondrashov, A. K. H. Kong, A. Kontos, N. Koper, M. Korobko, K. Kotake, M. Kovalam, D. B. Kozak, C. Kozakai, R. Kozu, V. Kringel, N. V. Krishnendu, A. Królak, G. Kuehn, F. Kuei, P. Kuijer, S. Kulkarni, A. Kumar, P. Kumar, Rahul Kumar, Rakesh Kumar, J. Kume, K. Kuns, C. Kuo, H-S. Kuo, Y. Kuromiya, S. Kuroyanagi, K. Kusayanagi, S. Kuwahara, K. Kwak, P. Lagabbe, D. Laghi, E. Lalande, T. L. Lam, A. Lamberts, M. Landry, B. B. Lane, R. N. Lang, J. Lange, B. Lantz, I. La Rosa, A. Lartaux-Vollard, P. D. Lasky, M. Laxen, A. Lazzarini, C. Lazzaro, P. Leaci, S. Leavey, Y. K. Lecoeuche, H. K. Lee, H. M. Lee, H. W. Lee, J. Lee, K. Lee, R. Lee, J. Lehmann, A. Lemaître, M. Leonardi, N. Leroy, N. Letendre, C. Levesque, Y. Levin, J. N. Leviton, K. Leyde, A. K. Y. Li, B. Li, J. Li, K. L. Li, T. G. F. Li, X. Li, C-Y. Lin, F-K. Lin, F-L. Lin, H. L. Lin, L. C.-C. Lin, F. Linde, S. D. Linker, J. N. Linley, T. B. Littenberg, G. C. Liu, J. Liu, K. Liu, X. Liu, F. Llamas, M. Llorens-Monteagudo, R. K. L. Lo, A. Lockwood, M. Loh, L. T. London, A. Longo, D. Lopez, M. Lopez Portilla, M. Lorenzini, V. Loriette, M. Lormand, G. Losurdo, T. P. Lott, J. D. Lough, C. O. Lousto, G. Lovelace, J. F. Lucaccioni, H. Lück, D. Lumaca, A. P. Lundgren, L.-W. Luo, J. E. Lynam, R. Macas, M. MacInnis, D. M. Macleod, I. A. O. MacMillan, A. Macquet, I. Magaña Hernandez, C. Magazzù, R. M. Magee, R. Maggiore, M. Magnozzi, S. Mahesh, E. Majorana, C. Makarem, I. Maksimovic, S. Maliakal, A. Malik, N. Man, V. Mandic, V. Mangano, J. L. Mango, G. L. Mansell, M. Manske, M. Mantovani, M. Mapelli, F. Marchesoni, M. Marchio, F. Marion, Z. Mark, S. Márka, Z. Márka, C. Markakis, A. S. Markosyan, A. Markowitz, E. Maros, A. Marquina, S. Marsat, F. Martelli, I. W. Martin, R. M. Martin, M. Martinez, V. A. Martinez, V. Martinez, K. Martinovic, D. V. Martynov, E. J. Marx, H. Masalehdan, K. Mason, E. Massera, A. Masserot, T. J. Massinger, M. Masso-Reid, S. Mastrogiovanni, A. Matas, M. Mateu-Lucena, F. Matichard, M. Matiushechkina, N. Mavalvala, J. J. McCann, R. McCarthy, D. E. McClelland, P. K. McClincy, S. McCormick, L. McCuller, G. I. McGhee, S. C. McGuire, C. McIsaac, J. McIver, T. McRae, S. T. McWilliams, D. Meacher, M. Mehmet, A. K. Mehta, Q. Meijer, A. Melatos, D. A. Melchor, G. Mendell, A. Menendez-Vazquez, C. S. Menoni, R. A. Mercer, L. Mereni, K. Merfeld, E. L. Merilh, J. D. Merritt, M. Merzougui, S. Meshkov, C. Messenger, C. Messick, P. M. Meyers, F. Meylahn, A. Mhaske, A. Miani, H. Miao, I. Michaloliakos, C. Michel, Y. Michimura, H. Middleton, L. Milano, A. L. Miller, A. Miller, B. Miller, M. Millhouse, J. C. Mills, E. Milotti, O. Minazzoli, Y. Minenkov, N. Mio, Ll. M. Mir, M. Miravet-Tenés, C. Mishra, T. Mishra, T. Mistry, S. Mitra, V. P. Mitrofanov, G. Mitselmakher, R. Mittleman, O. Miyakawa, A. Miyamoto, Y. Miyazaki, K. Miyo, S. Miyoki, Geoffrey Mo, L. M. Modafferi, E. Moguel, K. Mogushi, S. R. P. Mohapatra, S. R. Mohite, I. Molina, M. Molina-Ruiz, M. Mondin, M. Montani, C. J. Moore, D. Moraru, F. Morawski, A. More, C. Moreno, G. Moreno, Y. Mori, S. Morisaki, Y. Moriwaki, G. Morrás, B. Mours, C. M. Mow-Lowry, S. Mozzon, F. Muciaccia, Arunava Mukherjee, D. Mukherjee, Soma Mukherjee, Subroto Mukherjee, Suvodip Mukherjee, N. Mukund, A. Mullavey, J. Munch, E. A. Muñiz, P. G. Murray, R. Musenich, S. Muusse, S. L. Nadji, K. Nagano, S. Nagano, A. Nagar, K. Nakamura, H. Nakano, M. Nakano, R. Nakashima, Y. Nakayama, V. Napolano, I. Nardecchia, T. Narikawa, L. Naticchioni, B. Nayak, R. K. Nayak, R. Negishi, B. F. Neil, J. Neilson, G. Nelemans, T. J. N. Nelson, M. Nery, P. Neubauer, A. Neunzert, K. Y. Ng, S. W. S. Ng, C. Nguyen, P. Nguyen, T. Nguyen, L. Nguyen Quynh, W.-T. Ni, S. A. Nichols, A. Nishizawa, S. Nissanke, E. Nitoglia, F. Nocera, M. Norman, C. North, S. Nozaki, J. F. Nuño Siles, L. K. Nuttall, J. Oberling, B. D. O’Brien, Y. Obuchi, J. O’Dell, E. Oelker, W. Ogaki, G. Oganesyan, J. J. Oh, K. Oh, S. H. Oh, M. Ohashi, N. Ohishi, M. Ohkawa, F. Ohme, H. Ohta, M. A. Okada, Y. Okutani, K. Okutomi, C. Olivetto, K. Oohara, C. Ooi, R. Oram, B. O’Reilly, R. G. Ormiston, N. D. Ormsby, L. F. Ortega, R. O’Shaughnessy, E. O’Shea, S. Oshino, S. Ossokine, C. Osthelder, S. Otabe, D. J. Ottaway, H. Overmier, A. E. Pace, G. Pagano, M. A. Page, G. Pagliaroli, A. Pai, S. A. Pai, J. R. Palamos, O. Palashov, C. Palomba, H. Pan, K. Pan, P. K. Panda, H. Pang, P. T. H. Pang, C. Pankow, F. Pannarale, B. C. Pant, F. H. Panther, F. Paoletti, A. Paoli, A. Paolone, A. Parisi, H. Park, J. Park, W. Parker, D. Pascucci, A. Pasqualetti, R. Passaquieti, D. Passuello, M. Patel, M. Pathak, B. Patricelli, A. S. Patron, S. Paul, E. Payne, M. Pedraza, M. Pegoraro, A. Pele, F. E. Peña Arellano, S. Penn, A. Perego, A. Pereira, T. Pereira, C. J. Perez, C. Périgois, C. C. Perkins, A. Perreca, S. Perriès, J. Petermann, D. Petterson, H. P. Pfeiffer, K. A. Pham, K. S. Phukon, O. J. Piccinni, M. Pichot, M. Piendibene, F. Piergiovanni, L. Pierini, V. Pierro, G. Pillant, M. Pillas, F. Pilo, L. Pinard, I. M. Pinto, M. Pinto, B. Piotrzkowski, K. Piotrzkowski, M. Pirello, M. D. Pitkin, E. Placidi, L. Planas, W. Plastino, C. Pluchar, R. Poggiani, E. Polini, D. Y. T. Pong, S. Ponrathnam, P. Popolizio, E. K. Porter, R. Poulton, J. Powell, M. Pracchia, T. Pradier, A. K. Prajapati, K. Prasai, R. Prasanna, G. Pratten, M. Principe, G. A. Prodi, L. Prokhorov, P. Prosposito, L. Prudenzi, A. Puecher, M. Punturo, F. Puosi, P. Puppo, M. Pürrer, H. Qi, V. Quetschke, R. Quitzow-James, N. Qutob, F. J. Raab, G. Raaijmakers, H. Radkins, N. Radulesco, P. Raffai, S. X. Rail, S. Raja, C. Rajan, K. E. Ramirez, T. D. Ramirez, A. Ramos-Buades, J. Rana, P. Rapagnani, U. D. Rapol, A. Ray, V. Raymond, N. Raza, M. Razzano, J. Read, L. A. Rees, T. Regimbau, L. Rei, S. Reid, S. W. Reid, D. H. Reitze, P. Relton, A. Renzini, P. Rettegno, A. Reza, M. Rezac, F. Ricci, D. Richards, J. W. Richardson, L. Richardson, G. Riemenschneider, K. Riles, S. Rinaldi, K. Rink, M. Rizzo, N. A. Robertson, R. Robie, F. Robinet, A. Rocchi, S. Rodriguez, L. Rolland, J. G. Rollins, M. Romanelli, R. Romano, C. L. Romel, A. Romero-Rodríguez, I. M. Romero-Shaw, J. H. Romie, S. Ronchini, L. Rosa, C. A. Rose, D. Rosińska, M. P. Ross, S. Rowan, S. J. Rowlinson, S. Roy, Santosh Roy, Soumen Roy, D. Rozza, P. Ruggi, K. Ruiz-Rocha, K. Ryan, S. Sachdev, T. Sadecki, J. Sadiq, N. Sago, S. Saito, Y. Saito, K. Sakai, Y. Sakai, M. Sakellariadou, Y. Sakuno, O. S. Salafia, L. Salconi, M. Saleem, F. Salemi, A. Samajdar, E. J. Sanchez, J. H. Sanchez, L. E. Sanchez, N. Sanchis-Gual, J. R. Sanders, A. Sanuy, T. R. Saravanan, N. Sarin, B. Sassolas, H. Satari, B. S. Sathyaprakash, S. Sato, T. Sato, O. Sauter, R. L. Savage, T. Sawada, D. Sawant, H. L. Sawant, S. Sayah, D. Schaetzl, M. Scheel, J. Scheuer, M. Schiworski, P. Schmidt, S. Schmidt, R. Schnabel, M. Schneewind, R. M. S. Schofield, A. Schönbeck, B. W. Schulte, B. F. Schutz, E. Schwartz, J. Scott, S. M. Scott, M. Seglar-Arroyo, T. Sekiguchi, Y. Sekiguchi, D. Sellers, A. S. Sengupta, D. Sentenac, E. G. Seo, V. Sequino, A. Sergeev, Y. Setyawati, T. Shaffer, M. S. Shahriar, B. Shams, L. Shao, A. Sharma, P. Sharma, P. Shawhan, N. S. Shcheblanov, S. Shibagaki, M. Shikauchi, R. Shimizu, T. Shimoda, K. Shimode, H. Shinkai, T. Shishido, A. Shoda, D. H. Shoemaker, D. M. Shoemaker, S. ShyamSundar, M. Sieniawska, D. Sigg, L. P. Singer, D. Singh, N. Singh, A. Singha, A. M. Sintes, V. Sipala, V. Skliris, B. J. J. Slagmolen, T. J. Slaven-Blair, J. Smetana, J. R. Smith, R. J. E. Smith, J. Soldateschi, S. N. Somala, K. Somiya, E. J. Son, K. Soni, S. Soni, V. Sordini, F. Sorrentino, N. Sorrentino, H. Sotani, R. Soulard, T. Souradeep, E. Sowell, V. Spagnuolo, A. P. Spencer, M. Spera, R. Srinivasan, A. K. Srivastava, V. Srivastava, K. Staats, C. Stachie, D. A. Steer, J. Steinhoff, J. Steinlechner, S. Steinlechner, S. P. Stevenson, D. J. Stops, M. Stover, K. A. Strain, L. C. Strang, G. Stratta, A. Strunk, R. Sturani, A. L. Stuver, S. Sudhagar, V. Sudhir, R. Sugimoto, H. G. Suh, A. G. Sullivan, J. M. Sullivan, T. Z. Summerscales, H. Sun, L. Sun, S. Sunil, A. Sur, J. Suresh, P. J. Sutton, Takamasa Suzuki, Toshikazu Suzuki, B. L. Swinkels, M. J. Szczepańczyk, P. Szewczyk, M. Tacca, H. Tagoshi, S. C. Tait, H. Takahashi, R. Takahashi, A. Takamori, S. Takano, H. Takeda, M. Takeda, C. J. Talbot, C. Talbot, H. Tanaka, Kazuyuki Tanaka, Kenta Tanaka, Taiki Tanaka, Takahiro Tanaka, A. J. Tanasijczuk, S. Tanioka, D. B. Tanner, D. Tao, L. Tao, E. N. Tapia San Martín, C. Taranto, J. D. Tasson, S. Telada, R. Tenorio, J. E. Terhune, L. Terkowski, M. P. Thirugnanasambandam, L. Thomas, M. Thomas, P. Thomas, J. E. Thompson, S. R. Thondapu, K. A. Thorne, E. Thrane, Shubhanshu Tiwari, Srishti Tiwari, V. Tiwari, A. M. Toivonen, K. Toland, A. E. Tolley, T. Tomaru, Y. Tomigami, T. Tomura, M. Tonelli, A. Torres-Forné, C. I. Torrie, I. Tosta e Melo, D. Töyrä, A. Trapananti, F. Travasso, G. Traylor, M. Trevor, M. C. Tringali, A. Tripathee, L. Troiano, A. Trovato, L. Trozzo, R. J. Trudeau, D. S. Tsai, D. Tsai, K. W. Tsang, T. Tsang, J-S. Tsao, M. Tse, R. Tso, K. Tsubono, S. Tsuchida, L. Tsukada, D. Tsuna, T. Tsutsui, T. Tsuzuki, K. Turbang, M. Turconi, D. Tuyenbayev, A. S. Ubhi, N. Uchikata, T. Uchiyama, R. P. Udall, A. Ueda, T. Uehara, K. Ueno, G. Ueshima, C. S. Unnikrishnan, F. Uraguchi, A. L. Urban, T. Ushiba, A. Utina, H. Vahlbruch, G. Vajente, A. Vajpeyi, G. Valdes, M. Valentini, V. Valsan, N. van Bakel, M. van Beuzekom, J. F. J. van den Brand, C. Van Den Broeck, D. C. Vander-Hyde, L. van der Schaaf, J. V. van Heijningen, J. Vanosky, M. H. P. M. van Putten, N. van Remortel, M. Vardaro, A. F. Vargas, V. Varma, M. Vasúth, A. Vecchio, G. Vedovato, J. Veitch, P. J. Veitch, J. Venneberg, G. Venugopalan, D. Verkindt, P. Verma, Y. Verma, D. Veske, F. Vetrano, A. Viceré, S. Vidyant, A. D. Viets, A. Vijaykumar, V. Villa-Ortega, J.-Y. Vinet, A. Virtuoso, S. Vitale, T. Vo, H. Vocca, E. R. G. von Reis, J. S. A. von Wrangel, C. Vorvick, S. P. Vyatchanin, L. E. Wade, M. Wade, K. J. Wagner, R. C. Walet, M. Walker, G. S. Wallace, L. Wallace, S. Walsh, J. Wang, J. Z. Wang, W. H. Wang, R. L. Ward, J. Warner, M. Was, T. Washimi, N. Y. Washington, J. Watchi, B. Weaver, S. A. Webster, M. Weinert, A. J. Weinstein, R. Weiss, C. M. Weller, R. A. Weller, F. Wellmann, L. Wen, P. Weßels, K. Wette, J. T. Whelan, D. D. White, B. F. Whiting, C. Whittle, D. Wilken, D. Williams, M. J. Williams, N. Williams, A. R. Williamson, J. L. Willis, B. Willke, D. J. Wilson, W. Winkler, C. C. Wipf, T. Wlodarczyk, G. Woan, J. Woehler, J. K. Wofford, I. C. F. Wong, C. Wu, D. S. Wu, H. Wu, S. Wu, D. M. Wysocki, L. Xiao, W-R. Xu, T. Yamada, H. Yamamoto, Kazuhiro Yamamoto, Kohei Yamamoto, T. Yamamoto, K. Yamashita, R. Yamazaki, F. W. Yang, L. Yang, Y. Yang, Yang Yang, Z. Yang, M. J. Yap, D. W. Yeeles, A. B. Yelikar, M. Ying, K. Yokogawa, J. Yokoyama, T. Yokozawa, J. Yoo, T. Yoshioka, Hang Yu, Haocun Yu, H. Yuzurihara, A Zadrożny, M. Zanolin, S. Zeidler, T. Zelenova, J.-P. Zendri, M. Zevin, M. Zhan, H. Zhang, J. Zhang, L. Zhang, T. Zhang, Y. Zhang, C. Zhao, G. Zhao, Y. Zhao, Yue Zhao, Y. Zheng, R. Zhou, Z. Zhou, X. J. Zhu, Z.-H. Zhu, A. B. Zimmerman, Y. Zlochower, M. E. Zucker, and J. Zweizig

Subjects
Physics, QC1-999
Abstract

The third Gravitational-Wave Transient Catalog (GWTC-3) describes signals detected with Advanced LIGO and Advanced Virgo up to the end of their third observing run. Updating the previous GWTC-2.1, we present candidate gravitational waves from compact binary coalescences during the second half of the third observing run (O3b) between 1 November 2019, 15∶00 Coordinated Universal Time (UTC) and 27 March 2020, 17∶00 UTC. There are 35 compact binary coalescence candidates identified by at least one of our search algorithms with a probability of astrophysical origin p_{astro}>0.5. Of these, 18 were previously reported as low-latency public alerts, and 17 are reported here for the first time. Based upon estimates for the component masses, our O3b candidates with p_{astro}>0.5 are consistent with gravitational-wave signals from binary black holes or neutron-star–black-hole binaries, and we identify none from binary neutron stars. However, from the gravitational-wave data alone, we are not able to measure matter effects that distinguish whether the binary components are neutron stars or black holes. The range of inferred component masses is similar to that found with previous catalogs, but the O3b candidates include the first confident observations of neutron-star–black-hole binaries. Including the 35 candidates from O3b in addition to those from GWTC-2.1, GWTC-3 contains 90 candidates found by our analysis with p_{astro}>0.5 across the first three observing runs. These observations of compact binary coalescences present an unprecedented view of the properties of black holes and neutron stars.

Published
2023
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4. Treatment of ACL injury in a professional soccer player during COVID-19 lockdown

Author

I. Molina, A. Muñoz, and X. Linde

Subjects
Anterior cruciate ligament, Treatment, Physiotherapy, Soccer, COVID-19, Sports medicine, RC1200-1245
Abstract

Anterior Cruciate Ligament (ACL) injuries stand out as the most severe in sports such as soccer. This study presents the rehabilitation process of a professional soccer player who suffered a total ACL tear. It details the treatment performed after the surgical intervention and all the adaptations that had to be applied in the rehabilitation process due to the lockdown period established at the beginning of the COVID-19 pandemic. During the period comprised between weeks 9 and 21 post-surgery, the rehabilitation treatment was carried out virtually, adapting the actions, work environment and equipment used. Despite the limitations it entailed, the virtual format and the adaptations in the treatment allowed the rehabilitation process to continue, fulfilling all the pre-established objectives and deadlines with a consequent satisfactory and safe return to competitive sport. After carrying out a bibliographic research, no clinical cases have been found regarding the adaptation of the rehabilitation process of an ACL reconstruction in a professional soccer player during the COVID-19 lockdown.

Published
2022
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5. Impact of the COVID-19 pandemic on tuberculosis management in Spain

Author

M.L. Aznar, J. Espinosa-Pereiro, N. Saborit, N. Jové, F. Sánchez Martinez, S. Pérez-Recio, A. Vitoria, I. Sanjoaquin, E. Gallardo, J. Llenas-García, V. Pomar, I.O. García, J. Cacho, Lisbeth Goncalves De Freitas, J.V. San Martin, J.F. García Rodriguez, M.Á. Jiménez-Fuentes, M.L. De Souza-Galvao, T. Tórtola, R. Zules, I. Molina, and Adrián Sánchez-Montalvá

Subjects
Tuberculosis, COVID-19, Impact, Household contact screening, Pandemic, Transmission, Infectious and parasitic diseases, RC109-216
Abstract

Background: The impact of COVID-19 on the diagnosis and management of tuberculosis (TB) patients is unknown. Methods: Participating centres completed a structured web-based survey regarding changes to TB patient management during the COVID-19 pandemic. The study also included data from participating centres on patients aged ≥18 diagnosed with TB in 2 periods: March 15 to June 30, 2020 and March 15 to June 30, 2019. Clinical variables and information about patient household contacts were retrospectively collected. Results: A total of 7 (70%) TB units reported changes in their usual TB team operations. Across both periods of study, 169 patients were diagnosed with active TB (90 in 2019, 79 in 2020). Patients diagnosed in 2020 showed more frequent bilateral lesions in chest X-ray than patients diagnosed in 2019 (P = 0.004). There was a higher percentage of latent TB infection and active TB among children in households of patients diagnosed in 2020, compared with 2019 (P = 0.001). Conclusions: The COVID-19 pandemic has caused substantial changes in TB care. TB patients diagnosed during the COVID-19 pandemic showed more extended pulmonary forms. The increase in latent TB infection and active TB in children of patient households could reflect increased household transmission due to anti-COVID-19 measures.

Published
2021
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6. Efficacy and safety assessment of different dosage of benznidazol for the treatment of Chagas disease in chronic phase in adults (MULTIBENZ study): study protocol for a multicenter randomized Phase II non-inferiority clinical trial

Author

D. Molina-Morant, M. L. Fernández, P. Bosch-Nicolau, E. Sulleiro, M. Bangher, F. Salvador, A. Sanchez-Montalva, A. L. P. Ribeiro, A. M. B. de Paula, S. Eloi, R. Correa-Oliveira, J. C. Villar, S. Sosa-Estani, and I. Molina

Subjects
Chagas disease, Benznidazole, Therapeutic, Multicenter study, Clinical trial, Medicine (General), R5-920
Abstract

Abstract Background Chagas disease (CD) continues to be a neglected infectious disease with one of the largest burdens globally. Despite the modest cure rates in adult chronic patients and its safety profile, benznidazole (BNZ) is still the drug of choice. Its current recommended dose is based on nonrandomized studies, and efficacy and safety of the optimal dose of BNZ have been scarcely analyzed in clinical trials. Methods/design MULTIBENZ is a phase II, randomized, noninferiority, double-blind, multicenter international clinical trial. A total of 240 patients with Trypanosoma CD in the chronic phase will be recruited in four different countries (Argentina, Brazil, Colombia, and Spain). Patients will be randomized to receive BNZ 150 mg/day for 60 days, 400 mg/day for 15 days, or 300 mg/day for 60 days (comparator arm). The primary outcome is the efficacy of three different BNZ therapeutic schemes in terms of dose and duration. Efficacy will be assessed according to the proportion of patients with sustained parasitic load suppression in peripheral blood measured by polymerase chain reaction. The secondary outcomes are related to pharmacokinetics and drug tolerability. The follow-up will be 12 months from randomization to end of study participation. Recruitment was started in April 2018. Conclusion This is a clinical trial conducted for the assessment of different dose schemes of BNZ compared with the standard treatment regimen for the treatment of CD in the chronic phase. MULTIBENZ may help to clarify which is the most adequate BNZ regimen in terms of efficacy and safety, predicated on sustained parasitic load suppression in peripheral blood. Trial registration ClinicalTrials.gov, NCT03191162 . Registered on 19 June 2017.

Published
2020
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7. Population of Merging Compact Binaries Inferred Using Gravitational Waves through GWTC-3

Author

R. Abbott, T. D. Abbott, F. Acernese, K. Ackley, C. Adams, N. Adhikari, R. X. Adhikari, V. B. Adya, C. Affeldt, D. Agarwal, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, L. Aiello, A. Ain, P. Ajith, T. Akutsu, P. F. de Alarcón, S. Akcay, S. Albanesi, A. Allocca, P. A. Altin, A. Amato, C. Anand, S. Anand, A. Ananyeva, S. B. Anderson, W. G. Anderson, M. Ando, T. Andrade, N. Andres, T. Andrić, S. V. Angelova, S. Ansoldi, J. M. Antelis, S. Antier, F. Antonini, S. Appert, Koji Arai, Koya Arai, Y. Arai, S. Araki, A. Araya, M. C. Araya, J. S. Areeda, M. Arène, N. Aritomi, N. Arnaud, M. Arogeti, S. M. Aronson, K. G. Arun, H. Asada, Y. Asali, G. Ashton, Y. Aso, M. Assiduo, S. M. Aston, P. Astone, F. Aubin, C. Austin, S. Babak, F. Badaracco, M. K. M. Bader, C. Badger, S. Bae, Y. Bae, A. M. Baer, S. Bagnasco, Y. Bai, L. Baiotti, J. Baird, R. Bajpai, M. Ball, G. Ballardin, S. W. Ballmer, A. Balsamo, G. Baltus, S. Banagiri, D. Bankar, J. C. Barayoga, C. Barbieri, B. C. Barish, D. Barker, P. Barneo, F. Barone, B. Barr, L. Barsotti, M. Barsuglia, D. Barta, J. Bartlett, M. A. Barton, I. Bartos, R. Bassiri, A. Basti, M. Bawaj, J. C. Bayley, A. C. Baylor, M. Bazzan, B. Bécsy, V. M. Bedakihale, M. Bejger, I. Belahcene, V. Benedetto, D. Beniwal, T. F. Bennett, J. D. Bentley, M. BenYaala, F. Bergamin, B. K. Berger, S. Bernuzzi, C. P. L. Berry, D. Bersanetti, A. Bertolini, J. Betzwieser, D. Beveridge, R. Bhandare, U. Bhardwaj, D. Bhattacharjee, S. Bhaumik, I. A. Bilenko, G. Billingsley, S. Bini, I. A. Birney, O. Birnholtz, S. Biscans, M. Bischi, S. Biscoveanu, A. Bisht, B. Biswas, M. Bitossi, M.-A. Bizouard, J. K. Blackburn, C. D. Blair, D. G. Blair, R. M. Blair, F. Bobba, N. Bode, M. Boer, G. Bogaert, M. Boldrini, L. D. Bonavena, F. Bondu, E. Bonilla, R. Bonnand, P. Booker, B. A. Boom, R. Bork, V. Boschi, N. Bose, S. Bose, V. Bossilkov, V. Boudart, Y. Bouffanais, A. Bozzi, C. Bradaschia, P. R. Brady, A. Bramley, A. Branch, M. Branchesi, J. Brandt, J. E. Brau, M. Breschi, T. Briant, J. H. Briggs, A. Brillet, M. Brinkmann, P. Brockill, A. F. Brooks, J. Brooks, D. D. Brown, S. Brunett, G. Bruno, R. Bruntz, J. Bryant, T. Bulik, H. J. Bulten, A. Buonanno, R. Buscicchio, D. Buskulic, C. Buy, R. L. Byer, L. Cadonati, G. Cagnoli, C. Cahillane, J. Calderón Bustillo, J. D. Callaghan, T. A. Callister, E. Calloni, J. Cameron, J. B. Camp, M. Canepa, S. Canevarolo, M. Cannavacciuolo, K. C. Cannon, H. Cao, Z. Cao, E. Capocasa, E. Capote, G. Carapella, F. Carbognani, J. B. Carlin, M. F. Carney, M. Carpinelli, G. Carrillo, G. Carullo, T. L. Carver, J. Casanueva Diaz, C. Casentini, G. Castaldi, S. Caudill, M. Cavaglià, F. Cavalier, R. Cavalieri, M. Ceasar, G. Cella, P. Cerdá-Durán, E. Cesarini, W. Chaibi, K. Chakravarti, S. Chalathadka Subrahmanya, E. Champion, C.-H. Chan, C. Chan, C. L. Chan, K. Chan, M. Chan, K. Chandra, P. Chanial, S. Chao, C. E. A. Chapman-Bird, P. Charlton, E. A. Chase, E. Chassande-Mottin, C. Chatterjee, Debarati Chatterjee, Deep Chatterjee, M. Chaturvedi, S. Chaty, K. Chatziioannou, C. Chen, H. Y. Chen, J. Chen, K. Chen, X. Chen, Y.-B. Chen, Y.-R. Chen, Z. Chen, H. Cheng, C. K. Cheong, H. Y. Cheung, H. Y. Chia, F. Chiadini, C-Y. Chiang, G. Chiarini, R. Chierici, A. Chincarini, M. L. Chiofalo, A. Chiummo, G. Cho, H. S. Cho, R. K. Choudhary, S. Choudhary, N. Christensen, H. Chu, Q. Chu, Y-K. Chu, S. Chua, K. W. Chung, G. Ciani, P. Ciecielag, M. Cieślar, M. Cifaldi, A. A. Ciobanu, R. Ciolfi, F. Cipriano, A. Cirone, F. Clara, E. N. Clark, J. A. Clark, L. Clarke, P. Clearwater, S. Clesse, F. Cleva, E. Coccia, E. Codazzo, P.-F. Cohadon, D. E. Cohen, L. Cohen, M. Colleoni, C. G. Collette, A. Colombo, M. Colpi, C. M. Compton, M. Constancio, Jr., L. Conti, S. J. Cooper, P. Corban, T. R. Corbitt, I. Cordero-Carrión, S. Corezzi, K. R. Corley, N. Cornish, D. Corre, A. Corsi, S. Cortese, C. A. Costa, R. Cotesta, M. W. Coughlin, J.-P. Coulon, S. T. Countryman, B. Cousins, P. Couvares, D. M. Coward, M. J. Cowart, D. C. Coyne, R. Coyne, J. D. E. Creighton, T. D. Creighton, A. W. Criswell, M. Croquette, S. G. Crowder, J. R. Cudell, T. J. Cullen, A. Cumming, R. Cummings, L. Cunningham, E. Cuoco, M. Curyło, P. Dabadie, T. Dal Canton, S. Dall’Osso, G. Dálya, A. Dana, L. M. DaneshgaranBajastani, B. D’Angelo, B. Danila, S. Danilishin, S. D’Antonio, K. Danzmann, C. Darsow-Fromm, A. Dasgupta, L. E. H. Datrier, S. Datta, V. Dattilo, I. Dave, M. Davier, G. S. Davies, D. Davis, M. C. Davis, E. J. Daw, R. Dean, D. DeBra, M. Deenadayalan, J. Degallaix, M. De Laurentis, S. Deléglise, V. Del Favero, F. De Lillo, N. De Lillo, W. Del Pozzo, L. M. DeMarchi, F. De Matteis, V. D’Emilio, N. Demos, T. Dent, A. Depasse, R. De Pietri, R. De Rosa, C. De Rossi, R. DeSalvo, R. De Simone, S. Dhurandhar, M. C. Díaz, M. Diaz-Ortiz, Jr., N. A. Didio, T. Dietrich, L. Di Fiore, C. Di Fronzo, C. Di Giorgio, F. Di Giovanni, M. Di Giovanni, T. Di Girolamo, A. Di Lieto, B. Ding, S. Di Pace, I. Di Palma, F. Di Renzo, A. K. Divakarla, A. Dmitriev, Z. 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Weller, F. Wellmann, L. Wen, P. Weßels, K. Wette, J. T. Whelan, D. D. White, B. F. Whiting, C. Whittle, D. Wilken, D. Williams, M. J. Williams, A. R. Williamson, J. L. Willis, B. Willke, D. J. Wilson, W. Winkler, C. C. Wipf, T. Wlodarczyk, G. Woan, J. Woehler, J. K. Wofford, I. C. F. Wong, C. Wu, D. S. Wu, H. Wu, S. Wu, D. M. Wysocki, L. Xiao, W-R. Xu, T. Yamada, H. Yamamoto, Kazuhiro Yamamoto, Kohei Yamamoto, T. Yamamoto, K. Yamashita, R. Yamazaki, F. W. Yang, L. Yang, Y. Yang, Yang Yang, Z. Yang, M. J. Yap, D. W. Yeeles, A. B. Yelikar, M. Ying, K. Yokogawa, J. Yokoyama, T. Yokozawa, J. Yoo, T. Yoshioka, Hang Yu, Haocun Yu, H. Yuzurihara, A. Zadrożny, M. Zanolin, S. Zeidler, T. Zelenova, J.-P. Zendri, M. Zevin, M. Zhan, H. Zhang, J. Zhang, L. Zhang, T. Zhang, Y. Zhang, C. Zhao, G. Zhao, Y. Zhao, Yue Zhao, Y. Zheng, R. Zhou, Z. Zhou, X. J. Zhu, Z.-H. Zhu, A. B. Zimmerman, Y. Zlochower, M. E. Zucker, and J. Zweizig

Subjects
Physics, QC1-999
Abstract

We report on the population properties of compact binary mergers inferred from gravitational-wave observations of these systems during the first three LIGO-Virgo observing runs. The Gravitational-Wave Transient Catalog 3 (GWTC-3) contains signals consistent with three classes of binary mergers: binary black hole, binary neutron star, and neutron star–black hole mergers. We infer the binary neutron star merger rate to be between 10 and 1700 Gpc^{−3} yr^{−1} and the neutron star–black hole merger rate to be between 7.8 and 140 Gpc^{−3} yr^{−1}, assuming a constant rate density in the comoving frame and taking the union of 90% credible intervals for methods used in this work. We infer the binary black hole merger rate, allowing for evolution with redshift, to be between 17.9 and 44 Gpc^{-3} yr^{-1} at a fiducial redshift (z=0.2). The rate of binary black hole mergers is observed to increase with redshift at a rate proportional to (1+z)^{κ} with κ=2.9_{-1.8}^{+1.7} for z≲1. Using both binary neutron star and neutron star–black hole binaries, we obtain a broad, relatively flat neutron star mass distribution extending from 1.2_{-0.2}^{+0.1} to 2.0_{-0.3}^{+0.3}M_{⊙}. We confidently determine that the merger rate as a function of mass sharply declines after the expected maximum neutron star mass, but cannot yet confirm or rule out the existence of a lower mass gap between neutron stars and black holes. We also find the binary black hole mass distribution has localized over- and underdensities relative to a power-law distribution, with peaks emerging at chirp masses of 8.3_{-0.5}^{+0.3} and 27.9_{-1.8}^{+1.9}M_{⊙}. While we continue to find that the mass distribution of a binary’s more massive component strongly decreases as a function of primary mass, we observe no evidence of a strongly suppressed merger rate above approximately 60M_{⊙}, which would indicate the presence of a upper mass gap. Observed black hole spins are small, with half of spin magnitudes below χ_{i}≈0.25. While the majority of spins are preferentially aligned with the orbital angular momentum, we infer evidence of antialigned spins among the binary population. We observe an increase in spin magnitude for systems with more unequal-mass ratio. We also observe evidence of misalignment of spins relative to the orbital angular momentum.

Published
2023
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8. Search for Gravitational Waves Associated with Fast Radio Bursts Detected by CHIME/FRB during the LIGO–Virgo Observing Run O3a

Author

R. Abbott, T. D. Abbott, F. Acernese, K. Ackley, C. Adams, N. Adhikari, R. X. Adhikari, V. B. Adya, C. Affeldt, D. Agarwal, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, L. Aiello, A. Ain, P. Ajith, T. Akutsu, S. Albanesi, A. Allocca, P. A. Altin, A. Amato, C. Anand, S. Anand, A. Ananyeva, S. B. Anderson, W. G. Anderson, M. Ando, T. Andrade, N. Andres, T. Andrić, S. V. Angelova, S. Ansoldi, J. M. Antelis, S. Antier, S. Appert, Koji Arai, Koya Arai, Y. Arai, S. Araki, A. Araya, M. C. Araya, J. S. Areeda, M. Arène, N. Aritomi, N. Arnaud, S. M. Aronson, K. G. Arun, H. Asada, Y. Asali, G. Ashton, Y. Aso, M. Assiduo, S. M. Aston, P. Astone, F. Aubin, C. Austin, S. Babak, F. Badaracco, M. K. M. Bader, C. Badger, S. Bae, Y. Bae, A. M. Baer, S. Bagnasco, Y. Bai, L. Baiotti, J. Baird, R. Bajpai, M. Ball, G. Ballardin, S. W. Ballmer, A. Balsamo, G. Baltus, S. Banagiri, D. Bankar, J. C. Barayoga, C. Barbieri, B. C. Barish, D. Barker, P. Barneo, F. Barone, B. Barr, L. Barsotti, M. 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Fronzé, Y. Fujii, Y. Fujikawa, M. Fukunaga, M. Fukushima, P. Fulda, M. Fyffe, H. A. Gabbard, B. U. Gadre, J. R. Gair, J. Gais, S. Galaudage, R. Gamba, D. Ganapathy, A. Ganguly, D. Gao, S. G. Gaonkar, B. Garaventa, C. García-Núñez, C. García-Quirós, F. Garufi, B. Gateley, S. Gaudio, V. Gayathri, G.-G. Ge, G. Gemme, A. Gennai, J. George, O. Gerberding, L. Gergely, P. Gewecke, S. Ghonge, Abhirup Ghosh, Archisman Ghosh, Shaon Ghosh, Shrobana Ghosh, B. Giacomazzo, L. Giacoppo, J. A. Giaime, K. D. Giardina, D. R. Gibson, C. Gier, M. Giesler, P. Giri, F. Gissi, J. Glanzer, A. E. Gleckl, P. Godwin, E. Goetz, R. Goetz, N. Gohlke, B. Goncharov, G. González, A. Gopakumar, M. Gosselin, R. Gouaty, D. W. Gould, B. Grace, A. Grado, M. Granata, V. Granata, A. Grant, S. Gras, P. Grassia, C. Gray, R. Gray, G. Greco, A. C. Green, R. Green, A. M. Gretarsson, E. M. Gretarsson, D. Griffith, W. Griffiths, H. L. Griggs, G. Grignani, A. Grimaldi, S. J. Grimm, H. Grote, S. Grunewald, P. Gruning, D. Guerra, G. 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Zwaniga, The LIGO Scientific Collaboration, The Virgo Collaboration, The KAGRA Collaboration, and The CHIME/FRB Collaboration

Subjects
Gravitational wave astronomy, Radio transient sources, Astrophysics, QB460-466
Abstract

We search for gravitational-wave (GW) transients associated with fast radio bursts (FRBs) detected by the Canadian Hydrogen Intensity Mapping Experiment Fast Radio Burst Project, during the first part of the third observing run of Advanced LIGO and Advanced Virgo (2019 April 1 15:00 UTC–2019 October 1 15:00 UTC). Triggers from 22 FRBs were analyzed with a search that targets both binary neutron star (BNS) and neutron star–black hole (NSBH) mergers. A targeted search for generic GW transients was conducted on 40 FRBs. We find no significant evidence for a GW association in either search. Given the large uncertainties in the distances of our FRB sample, we are unable to exclude the possibility of a GW association. Assessing the volumetric event rates of both FRB and binary mergers, an association is limited to 15% of the FRB population for BNS mergers or 1% for NSBH mergers. We report 90% confidence lower bounds on the distance to each FRB for a range of GW progenitor models and set upper limits on the energy emitted through GWs for a range of emission scenarios. We find values of order 10 ^51 –10 ^57 erg for models with central GW frequencies in the range 70–3560 Hz. At the sensitivity of this search, we find these limits to be above the predicted GW emissions for the models considered. We also find no significant coincident detection of GWs with the repeater, FRB 20200120E, which is the closest known extragalactic FRB.

Published
2023
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9. Observation of Gravitational Waves from Two Neutron Star–Black Hole Coalescences

Author

R. Abbott, T. D. Abbott, S. Abraham, F. Acernese, K. Ackley, A. Adams, C. Adams, R. X. Adhikari, V. B. Adya, C. Affeldt, D. Agarwal, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, L. Aiello, A. Ain, P. Ajith, T. Akutsu, K. M. Aleman, G. Allen, A. Allocca, P. A. Altin, A. Amato, S. Anand, A. Ananyeva, S. B. Anderson, W. G. Anderson, M. Ando, S. V. Angelova, S. Ansoldi, J. M. Antelis, S. Antier, S. Appert, Koya Arai, Koji Arai, Y. Arai, S. Araki, A. Araya, M. C. Araya, J. S. Areeda, M. Arène, N. Aritomi, N. Arnaud, S. M. Aronson, K. G. Arun, H. Asada, Y. Asali, G. Ashton, Y. Aso, S. M. Aston, P. Astone, F. Aubin, P. Aufmuth, K. AultONeal, C. Austin, S. Babak, F. Badaracco, M. K. M. Bader, S. Bae, Y. Bae, A. M. Baer, S. Bagnasco, Y. Bai, L. Baiotti, J. Baird, R. Bajpai, M. Ball, G. Ballardin, S. W. Ballmer, M. Bals, A. Balsamo, G. Baltus, S. Banagiri, D. Bankar, R. S. Bankar, J. C. Barayoga, C. Barbieri, B. C. Barish, D. Barker, P. Barneo, F. Barone, B. Barr, L. Barsotti, M. 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Zhang, J. Zhang, L. Zhang, R. Zhang, T. Zhang, C. Zhao, G. Zhao, Yue Zhao, Yuhang Zhao, Z. Zhou, X. J. Zhu, Z.-H. Zhu, A. B. Zimmerman, Y. Zlochower, M. E. Zucker, J. Zweizig, and the LIGO Scientific Collaboration, the Virgo Collaboration, and the KAGRA Collaboration

Subjects
Astrophysics, QB460-466
Abstract

We report the observation of gravitational waves from two compact binary coalescences in LIGO’s and Virgo’s third observing run with properties consistent with neutron star–black hole (NSBH) binaries. The two events are named GW200105_162426 and GW200115_042309, abbreviated as GW200105 and GW200115; the first was observed by LIGO Livingston and Virgo and the second by all three LIGO–Virgo detectors. The source of GW200105 has component masses $8.{9}_{-1.5}^{+1.2}$ and $1.{9}_{-0.2}^{+0.3}\,{M}_{\odot }$ , whereas the source of GW200115 has component masses $5.{7}_{-2.1}^{+1.8}$ and $1.{5}_{-0.3}^{+0.7}\,{M}_{\odot }$ (all measurements quoted at the 90% credible level). The probability that the secondary’s mass is below the maximal mass of a neutron star is 89%–96% and 87%–98%, respectively, for GW200105 and GW200115, with the ranges arising from different astrophysical assumptions. The source luminosity distances are ${280}_{-110}^{+110}$ and ${300}_{-100}^{+150}\,\mathrm{Mpc}$ , respectively. The magnitude of the primary spin of GW200105 is less than 0.23 at the 90% credible level, and its orientation is unconstrained. For GW200115, the primary spin has a negative spin projection onto the orbital angular momentum at 88% probability. We are unable to constrain the spin or tidal deformation of the secondary component for either event. We infer an NSBH merger rate density of ${45}_{-33}^{+75}\,{\mathrm{Gpc}}^{-3}\,{\mathrm{yr}}^{-1}$ when assuming that GW200105 and GW200115 are representative of the NSBH population or ${130}_{-69}^{+112}\,{\mathrm{Gpc}}^{-3}\,{\mathrm{yr}}^{-1}$ under the assumption of a broader distribution of component masses.

Published
2021
Full Text
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10. Narrowband Searches for Continuous and Long-duration Transient Gravitational Waves from Known Pulsars in the LIGO-Virgo Third Observing Run

Author

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Napolano, I. Nardecchia, T. Narikawa, L. Naticchioni, B. Nayak, R. K. Nayak, R. Negishi, B. F. Neil, J. Neilson, G. Nelemans, T. J. N. Nelson, M. Nery, P. Neubauer, A. Neunzert, K. Y. Ng, S. W. S. Ng, C. Nguyen, P. Nguyen, T. Nguyen, L. Nguyen Quynh, W.-T. Ni, S. A. Nichols, A. Nishizawa, S. Nissanke, E. Nitoglia, F. Nocera, M. Norman, C. North, S. Nozaki, L. K. Nuttall, J. Oberling, B. D. O’Brien, Y. Obuchi, J. O’Dell, E. Oelker, W. Ogaki, G. Oganesyan, J. J. Oh, K. Oh, S. H. Oh, M. Ohashi, N. Ohishi, M. Ohkawa, F. Ohme, H. Ohta, M. A. Okada, Y. Okutani, K. Okutomi, C. Olivetto, K. Oohara, C. Ooi, R. Oram, B. O’Reilly, R. G. Ormiston, N. D. Ormsby, L. F. Ortega, R. O’Shaughnessy, E. O’Shea, S. Oshino, S. Ossokine, C. Osthelder, S. Otabe, D. J. Ottaway, H. Overmier, A. E. Pace, G. Pagano, M. A. Page, G. Pagliaroli, A. Pai, S. A. Pai, J. R. Palamos, O. Palashov, C. Palomba, H. Pan, K. Pan, P. K. Panda, H. Pang, P. T. H. Pang, C. Pankow, F. Pannarale, B. C. Pant, F. H. Panther, F. Paoletti, A. Paoli, A. Paolone, A. Parisi, H. Park, J. Park, W. Parker, D. Pascucci, A. Pasqualetti, R. Passaquieti, D. Passuello, M. Patel, M. Pathak, B. Patricelli, A. S. Patron, S. Patrone, S. Paul, E. Payne, M. Pedraza, M. Pegoraro, A. Pele, F. E. Peña Arellano, S. Penn, A. Perego, A. Pereira, T. Pereira, C. J. Perez, C. Périgois, C. C. Perkins, A. Perreca, S. Perriès, J. Petermann, D. Petterson, H. P. Pfeiffer, K. A. Pham, K. S. Phukon, O. J. Piccinni, M. Pichot, M. Piendibene, F. Piergiovanni, L. Pierini, V. Pierro, G. Pillant, M. Pillas, F. Pilo, L. Pinard, I. M. Pinto, M. Pinto, K. Piotrzkowski, M. Pirello, M. D. Pitkin, E. Placidi, L. Planas, W. Plastino, C. Pluchar, R. Poggiani, E. Polini, D. Y. T. Pong, S. Ponrathnam, P. Popolizio, E. K. Porter, R. Poulton, J. Powell, M. Pracchia, T. Pradier, A. K. Prajapati, K. Prasai, R. Prasanna, G. Pratten, M. Principe, G. A. Prodi, L. Prokhorov, P. Prosposito, L. Prudenzi, A. Puecher, M. Punturo, F. Puosi, P. Puppo, M. Pürrer, H. Qi, V. Quetschke, R. Quitzow-James, F. J. Raab, G. Raaijmakers, H. Radkins, N. Radulesco, P. Raffai, S. X. Rail, S. Raja, C. Rajan, K. E. Ramirez, T. D. Ramirez, A. Ramos-Buades, J. Rana, P. Rapagnani, U. D. Rapol, A. Ray, V. Raymond, N. Raza, M. Razzano, J. Read, L. A. Rees, T. Regimbau, L. Rei, S. Reid, S. W. Reid, D. H. Reitze, P. Relton, A. Renzini, P. Rettegno, M. Rezac, F. Ricci, D. Richards, J. W. Richardson, L. Richardson, G. Riemenschneider, K. Riles, S. Rinaldi, K. Rink, M. Rizzo, N. A. Robertson, R. Robie, F. Robinet, A. Rocchi, S. Rodriguez, L. Rolland, J. G. Rollins, M. Romanelli, R. Romano, C. L. Romel, A. Romero-Rodríguez, I. M. Romero-Shaw, J. H. Romie, S. Ronchini, L. Rosa, C. A. Rose, D. Rosińska, M. P. Ross, S. Rowan, S. J. Rowlinson, S. Roy, Santosh Roy, Soumen Roy, D. Rozza, P. Ruggi, K. Ryan, S. Sachdev, T. Sadecki, J. Sadiq, N. Sago, S. Saito, Y. Saito, K. Sakai, Y. Sakai, M. Sakellariadou, Y. Sakuno, O. S. Salafia, L. Salconi, M. Saleem, F. Salemi, A. Samajdar, E. J. Sanchez, J. H. Sanchez, L. E. Sanchez, N. Sanchis-Gual, J. R. Sanders, A. Sanuy, T. R. Saravanan, N. Sarin, B. Sassolas, H. Satari, S. Sato, T. Sato, O. Sauter, R. L. Savage, T. Sawada, D. Sawant, H. L. Sawant, S. Sayah, D. Schaetzl, M. Scheel, J. Scheuer, M. Schiworski, P. Schmidt, S. Schmidt, R. Schnabel, M. Schneewind, R. M. S. Schofield, A. Schönbeck, B. W. Schulte, B. F. Schutz, E. Schwartz, J. Scott, S. M. Scott, M. Seglar-Arroyo, T. Sekiguchi, Y. Sekiguchi, D. Sellers, A. S. Sengupta, D. Sentenac, E. G. Seo, V. Sequino, A. Sergeev, Y. Setyawati, T. Shaffer, M. S. Shahriar, B. Shams, L. Shao, A. Sharma, P. Sharma, P. Shawhan, N. S. Shcheblanov, S. Shibagaki, M. Shikauchi, R. Shimizu, T. Shimoda, K. Shimode, H. Shinkai, T. Shishido, A. Shoda, D. H. Shoemaker, D. M. Shoemaker, S. ShyamSundar, M. Sieniawska, D. Sigg, L. P. Singer, D. Singh, N. Singh, A. Singha, A. M. Sintes, V. Sipala, V. Skliris, B. J. J. Slagmolen, T. J. Slaven-Blair, J. Smetana, J. R. Smith, R. J. E. Smith, J. Soldateschi, S. N. Somala, K. Somiya, E. J. Son, K. Soni, S. Soni, V. Sordini, F. Sorrentino, N. Sorrentino, H. Sotani, R. Soulard, T. Souradeep, E. Sowell, V. Spagnuolo, A. P. Spencer, M. Spera, R. Srinivasan, A. K. Srivastava, V. Srivastava, K. Staats, C. Stachie, D. A. Steer, J. Steinlechner, S. Steinlechner, D. J. Stops, M. Stover, K. A. Strain, L. C. Strang, G. Stratta, A. Strunk, R. Sturani, A. L. Stuver, S. Sudhagar, V. Sudhir, R. Sugimoto, H. G. Suh, T. Z. Summerscales, H. Sun, L. Sun, S. Sunil, A. Sur, J. Suresh, P. J. Sutton, Takamasa Suzuki, Toshikazu Suzuki, B. L. Swinkels, M. J. Szczepańczyk, P. Szewczyk, M. Tacca, H. Tagoshi, S. C. Tait, H. Takahashi, R. Takahashi, A. Takamori, S. Takano, H. Takeda, M. Takeda, C. J. Talbot, C. Talbot, H. Tanaka, Kazuyuki Tanaka, Kenta Tanaka, Taiki Tanaka, Takahiro Tanaka, A. J. Tanasijczuk, S. Tanioka, D. B. Tanner, D. Tao, L. Tao, E. N. Tapia San Martín, C. Taranto, J. D. Tasson, S. Telada, R. Tenorio, J. E. Terhune, L. Terkowski, M. P. Thirugnanasambandam, M. Thomas, P. Thomas, J. E. Thompson, S. R. Thondapu, K. A. Thorne, E. Thrane, Shubhanshu Tiwari, Srishti Tiwari, V. Tiwari, A. M. Toivonen, K. Toland, A. E. Tolley, T. Tomaru, Y. Tomigami, T. Tomura, M. Tonelli, A. Torres-Forné, C. I. Torrie, I. Tosta e Melo, D. Töyrä, A. Trapananti, F. Travasso, G. Traylor, M. Trevor, M. C. Tringali, A. Tripathee, L. Troiano, A. Trovato, L. Trozzo, R. J. Trudeau, D. S. Tsai, D. Tsai, K. W. Tsang, T. Tsang, J-S. Tsao, M. Tse, R. Tso, K. Tsubono, S. Tsuchida, L. Tsukada, D. Tsuna, T. Tsutsui, T. Tsuzuki, K. Turbang, M. Turconi, D. Tuyenbayev, A. S. Ubhi, N. Uchikata, T. Uchiyama, R. P. Udall, A. Ueda, T. Uehara, K. Ueno, G. Ueshima, C. S. Unnikrishnan, F. Uraguchi, A. L. Urban, T. Ushiba, A. Utina, H. Vahlbruch, G. Vajente, A. Vajpeyi, G. Valdes, M. Valentini, V. Valsan, N. van Bakel, M. van Beuzekom, J. F. J. van den Brand, C. Van Den Broeck, D. C. Vander-Hyde, L. van der Schaaf, J. V. van Heijningen, J. Vanosky, M. H. P. M. van Putten, N. van Remortel, M. Vardaro, A. F. Vargas, V. Varma, M. Vasúth, A. Vecchio, G. Vedovato, J. Veitch, P. J. Veitch, J. Venneberg, G. Venugopalan, D. Verkindt, P. Verma, Y. Verma, D. Veske, F. Vetrano, A. Viceré, S. Vidyant, A. D. Viets, A. Vijaykumar, V. Villa-Ortega, J.-Y. Vinet, A. Virtuoso, S. Vitale, T. Vo, H. Vocca, E. R. G. von Reis, J. S. A. von Wrangel, C. Vorvick, S. P. Vyatchanin, L. E. Wade, M. Wade, K. J. Wagner, R. C. Walet, M. Walker, G. S. Wallace, L. Wallace, S. Walsh, J. Wang, J. Z. Wang, W. H. Wang, R. L. Ward, J. Warner, M. Was, T. Washimi, N. Y. Washington, J. Watchi, B. Weaver, S. A. Webster, M. Weinert, A. J. Weinstein, R. Weiss, C. M. Weller, F. Wellmann, L. Wen, P. Weßels, K. Wette, J. T. Whelan, D. D. White, B. F. Whiting, C. Whittle, D. Wilken, D. Williams, M. J. Williams, A. R. Williamson, J. L. Willis, B. Willke, D. J. Wilson, W. Winkler, C. C. Wipf, T. Wlodarczyk, G. Woan, J. Woehler, J. K. Wofford, I. C. F. Wong, C. Wu, D. S. Wu, H. Wu, S. Wu, D. M. Wysocki, L. Xiao, W-R. Xu, T. Yamada, H. Yamamoto, Kazuhiro Yamamoto, Kohei Yamamoto, T. Yamamoto, K. Yamashita, R. Yamazaki, F. W. Yang, L. Yang, Y. Yang, Yang Yang, Z. Yang, M. J. Yap, D. W. Yeeles, A. B. Yelikar, M. Ying, K. Yokogawa, J. Yokoyama, T. Yokozawa, J. Yoo, T. Yoshioka, Hang Yu, Haocun Yu, H. Yuzurihara, A. Zadrożny, M. Zanolin, S. Zeidler, T. Zelenova, J.-P. Zendri, M. Zevin, M. Zhan, H. Zhang, J. Zhang, L. Zhang, T. Zhang, Y. Zhang, C. Zhao, G. Zhao, Y. Zhao, Yue Zhao, R. Zhou, Z. Zhou, X. J. Zhu, Z.-H. Zhu, M. E. Zucker, J. Zweizig, The LIGO Scientific Collaboration, the Virgo Collaboration, and the KAGRA Collaboration, D. Antonopoulou, Z. Arzoumanian, A. Basu, S. Bogdanov, I. Cognard, K. Crowter, T. Enoto, C. M. Espinoza, C. M. L. Flynn, E. Fonseca, D. C. Good, L. Guillemot, S. Guillot, A. K. Harding, M. J. Keith, L. Kuiper, M. E. Lower, A. G. Lyne, J. W. McKee, B. W. Meyers, C. Ng, J. L. Palfreyman, R. M. Shannon, B. Shaw, I. H. Stairs, B. W. Stappers, C. M. Tan, G. Theureau, and P. Weltevrede

Subjects
Gravitational wave astronomy, Neutron stars, Pulsars, Astrophysics, QB460-466
Abstract

Isolated neutron stars that are asymmetric with respect to their spin axis are possible sources of detectable continuous gravitational waves. This paper presents a fully coherent search for such signals from eighteen pulsars in data from LIGO and Virgo’s third observing run (O3). For known pulsars, efficient and sensitive matched-filter searches can be carried out if one assumes the gravitational radiation is phase-locked to the electromagnetic emission. In the search presented here, we relax this assumption and allow both the frequency and the time derivative of the frequency of the gravitational waves to vary in a small range around those inferred from electromagnetic observations. We find no evidence for continuous gravitational waves, and set upper limits on the strain amplitude for each target. These limits are more constraining for seven of the targets than the spin-down limit defined by ascribing all rotational energy loss to gravitational radiation. In an additional search, we look in O3 data for long-duration (hours–months) transient gravitational waves in the aftermath of pulsar glitches for six targets with a total of nine glitches. We report two marginal outliers from this search, but find no clear evidence for such emission either. The resulting duration-dependent strain upper limits do not surpass indirect energy constraints for any of these targets.

Published
2022
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11. Molecular detection of Rickettsia infection in field-collected bed bugs

Author

R. Potts, I. Molina, J.M. Sheele, and J.E. Pietri

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Bed bugs are now one of the most prevalent human-associated, blood-feeding pests in the urban world, but few studies of their association with human pathogens have been conducted since their resurgence. Here, we used PCR to screen samples of field-collected bed bugs (Cimex spp.) for the presence of Rickettsia bacteria and we describe the first detection of an uncharacterized Rickettsia in Cimex lectularius in nature. Rickettsia was detected in 5/39 (12.8%) of the bed bug samples tested. In particular, three pools from the USA and two individual insects from the UK were positive for Rickettsia DNA. Sequencing and analysis of a fragment of the citrate synthase gene (gltA) from positive samples from each country revealed that the Rickettsia detected in both were identical and were closely related to a Rickettsia previously detected in the rat flea Nosopsyllus laeviceps. Additional experiments indicated that the Rickettsia localizes to multiple tissues in the bed bug and reaches high titres. Attempts were made to infect mammalian cells in culture but these efforts were inconclusive. Our findings suggest that Rickettsia are secondary endosymbionts of bed bugs and have potential implications for both bed bug control and public health. However, further investigation is required to determine the pathogenicity of this Rickettsia, its transmission mechanisms, and its contributions to bed bug physiology. Keywords: Bed bug, Cimex, detection, infection, pathogen, Rickettsia, symbiont

Published
2020
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12. GWTC-2: Compact Binary Coalescences Observed by LIGO and Virgo during the First Half of the Third Observing Run

Author

R. Abbott, T. D. Abbott, S. Abraham, F. Acernese, K. Ackley, A. Adams, C. Adams, R. X. Adhikari, V. B. Adya, C. Affeldt, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, L. Aiello, A. Ain, P. Ajith, S. Akcay, G. Allen, A. Allocca, P. A. Altin, A. Amato, S. Anand, A. Ananyeva, S. B. Anderson, W. G. Anderson, S. V. Angelova, S. Ansoldi, J. M. Antelis, S. Antier, S. Appert, K. Arai, M. C. Araya, J. S. Areeda, M. Arène, N. Arnaud, S. M. Aronson, K. G. Arun, Y. Asali, S. Ascenzi, G. Ashton, S. M. Aston, P. Astone, F. Aubin, P. Aufmuth, K. AultONeal, C. Austin, V. Avendano, S. Babak, F. Badaracco, M. K. M. Bader, S. Bae, A. M. Baer, S. Bagnasco, J. Baird, M. Ball, G. Ballardin, S. W. Ballmer, A. Bals, A. Balsamo, G. Baltus, S. Banagiri, D. Bankar, R. S. Bankar, J. C. Barayoga, C. Barbieri, B. C. Barish, D. Barker, P. Barneo, S. Barnum, F. Barone, B. Barr, L. Barsotti, M. Barsuglia, D. Barta, J. Bartlett, I. Bartos, R. Bassiri, A. Basti, M. Bawaj, J. C. Bayley, M. Bazzan, B. R. Becher, B. Bécsy, V. M. Bedakihale, M. Bejger, I. Belahcene, D. Beniwal, M. G. Benjamin, T. F. Bennett, J. D. Bentley, F. Bergamin, B. K. Berger, G. Bergmann, S. Bernuzzi, C. P. L. Berry, D. Bersanetti, A. Bertolini, J. Betzwieser, R. Bhandare, A. V. Bhandari, D. Bhattacharjee, J. Bidler, I. A. Bilenko, G. Billingsley, I. A. Birney, O. Birnholtz, S. Biscans, M. Bischi, S. Biscoveanu, A. Bisht, M. Bitossi, M.-A. Bizouard, J. K. Blackburn, J. Blackman, C. D. Blair, D. G. Blair, R. M. Blair, O. Blanch, F. Bobba, N. Bode, M. Boer, Y. Boetzel, G. Bogaert, M. Boldrini, F. Bondu, E. Bonilla, R. Bonnand, P. Booker, B. A. Boom, R. Bork, V. Boschi, S. Bose, V. Bossilkov, V. Boudart, Y. Bouffanais, A. Bozzi, C. Bradaschia, P. R. Brady, A. Bramley, M. Branchesi, J. E. Brau, M. Breschi, T. Briant, J. H. Briggs, F. Brighenti, A. Brillet, M. Brinkmann, P. Brockill, A. F. Brooks, J. Brooks, D. D. Brown, S. Brunett, G. Bruno, R. Bruntz, A. Buikema, T. Bulik, H. J. Bulten, A. Buonanno, R. Buscicchio, D. Buskulic, R. L. Byer, M. Cabero, L. Cadonati, M. Caesar, G. Cagnoli, C. Cahillane, J. Calderón Bustillo, J. D. Callaghan, T. A. Callister, E. Calloni, J. B. Camp, M. Canepa, K. C. Cannon, H. Cao, J. Cao, G. Carapella, F. Carbognani, M. F. Carney, M. Carpinelli, G. Carullo, T. L. Carver, J. Casanueva Diaz, C. Casentini, S. Caudill, M. Cavaglià, F. Cavalier, R. Cavalieri, G. Cella, P. Cerdá-Durán, E. Cesarini, W. Chaibi, K. Chakravarti, C.-L. Chan, C. Chan, K. Chandra, P. Chanial, S. Chao, P. Charlton, E. A. Chase, E. Chassande-Mottin, D. Chatterjee, D. Chattopadhyay, M. Chaturvedi, K. Chatziioannou, A. Chen, H. Y. Chen, X. Chen, Y. Chen, H.-P. Cheng, C. K. Cheong, H. Y. Chia, F. Chiadini, R. Chierici, A. Chincarini, A. Chiummo, G. Cho, H. S. Cho, M. Cho, S. Choate, N. Christensen, Q. Chu, S. Chua, K. W. Chung, S. Chung, G. Ciani, P. Ciecielag, M. Cieślar, M. Cifaldi, A. A. Ciobanu, R. Ciolfi, F. Cipriano, A. Cirone, F. Clara, E. N. Clark, J. A. Clark, L. Clarke, P. Clearwater, S. Clesse, F. Cleva, E. Coccia, P.-F. Cohadon, D. E. Cohen, M. Colleoni, C. G. Collette, C. Collins, M. Colpi, M. Constancio, Jr., L. Conti, S. J. Cooper, P. Corban, T. R. Corbitt, I. Cordero-Carrión, S. Corezzi, K. R. Corley, N. Cornish, D. Corre, A. Corsi, S. Cortese, C. A. Costa, R. Cotesta, M. W. Coughlin, S. B. Coughlin, J.-P. Coulon, S. T. Countryman, B. Cousins, P. Couvares, P. B. Covas, D. M. Coward, M. J. Cowart, D. C. Coyne, R. Coyne, J. D. E. Creighton, T. D. Creighton, M. Croquette, S. G. Crowder, J. R. Cudell, T. J. Cullen, A. Cumming, R. Cummings, L. Cunningham, E. Cuoco, M. Curyło, T. Dal Canton, G. Dálya, A. Dana, L. M. DaneshgaranBajastani, B. D’Angelo, B. Danila, S. L. Danilishin, S. D’Antonio, K. Danzmann, C. Darsow-Fromm, A. Dasgupta, L. E. H. Datrier, V. Dattilo, I. Dave, M. Davier, G. S. Davies, D. Davis, E. J. Daw, R. Dean, D. DeBra, M. Deenadayalan, J. Degallaix, M. De Laurentis, S. Deléglise, V. Del Favero, F. De Lillo, N. De Lillo, W. Del Pozzo, L. M. DeMarchi, F. De Matteis, V. D’Emilio, N. Demos, T. Denker, T. Dent, A. Depasse, R. De Pietri, R. De Rosa, C. De Rossi, R. DeSalvo, O. de Varona, S. Dhurandhar, M. C. Díaz, M. Diaz-Ortiz, Jr., N. A. Didio, T. Dietrich, L. Di Fiore, C. DiFronzo, C. Di Giorgio, F. Di Giovanni, M. Di Giovanni, T. Di Girolamo, A. Di Lieto, B. Ding, S. Di Pace, I. Di Palma, F. Di Renzo, A. K. Divakarla, A. Dmitriev, Z. Doctor, L. D’Onofrio, F. Donovan, K. L. Dooley, S. Doravari, I. Dorrington, T. P. Downes, M. Drago, J. C. Driggers, Z. Du, J.-G. Ducoin, P. Dupej, O. Durante, D. D’Urso, P.-A. Duverne, S. E. Dwyer, P. J. Easter, G. Eddolls, B. Edelman, T. B. Edo, O. Edy, A. Effler, J. Eichholz, S. S. Eikenberry, M. Eisenmann, R. A. Eisenstein, A. Ejlli, L. Errico, R. C. Essick, H. Estellés, D. Estevez, Z. B. Etienne, T. Etzel, M. Evans, T. M. Evans, B. E. Ewing, V. Fafone, H. Fair, S. Fairhurst, X. Fan, A. M. Farah, S. Farinon, B. Farr, W. M. Farr, E. J. Fauchon-Jones, M. Favata, M. Fays, M. Fazio, J. Feicht, M. M. Fejer, F. Feng, E. Fenyvesi, D. L. Ferguson, A. Fernandez-Galiana, I. Ferrante, T. A. Ferreira, F. Fidecaro, P. Figura, I. Fiori, D. Fiorucci, M. Fishbach, R. P. Fisher, J. M. Fishner, R. Fittipaldi, M. Fitz-Axen, V. Fiumara, R. Flaminio, E. Floden, E. Flynn, H. Fong, J. A. Font, P. W. F. Forsyth, J.-D. Fournier, S. Frasca, F. Frasconi, Z. Frei, A. Freise, R. Frey, V. Frey, P. Fritschel, V. V. Frolov, G. G. Fronzé, P. Fulda, M. Fyffe, H. A. Gabbard, B. U. Gadre, S. M. Gaebel, J. R. Gair, J. Gais, S. Galaudage, R. Gamba, D. Ganapathy, A. Ganguly, S. G. Gaonkar, B. Garaventa, C. García-Quirós, F. Garufi, B. Gateley, S. Gaudio, V. Gayathri, G. Gemme, A. Gennai, D. George, J. George, R. N. George, L. Gergely, S. Ghonge, Abhirup Ghosh, Archisman Ghosh, S. Ghosh, B. Giacomazzo, L. Giacoppo, J. A. Giaime, K. D. Giardina, D. R. Gibson, C. Gier, K. Gill, P. Giri, J. Glanzer, A. E. Gleckl, P. Godwin, E. Goetz, R. Goetz, N. Gohlke, B. Goncharov, G. González, A. Gopakumar, S. E. Gossan, M. Gosselin, R. Gouaty, B. Grace, A. Grado, M. Granata, V. Granata, A. Grant, S. Gras, P. Grassia, C. Gray, R. Gray, G. Greco, A. C. Green, R. Green, E. M. Gretarsson, H. L. Griggs, G. Grignani, A. Grimaldi, E. Grimes, S. J. Grimm, H. Grote, S. Grunewald, P. Gruning, J. G. Guerrero, G. M. Guidi, A. R. Guimaraes, G. Guixé, H. K. Gulati, Y. Guo, Anchal Gupta, Anuradha Gupta, P. Gupta, E. K. Gustafson, R. Gustafson, F. Guzman, L. Haegel, O. Halim, E. D. Hall, E. Z. Hamilton, G. Hammond, M. Haney, M. M. Hanke, J. Hanks, C. Hanna, M. D. Hannam, O. A. Hannuksela, O. Hannuksela, H. Hansen, T. J. Hansen, J. Hanson, T. Harder, T. Hardwick, K. Haris, J. Harms, G. M. Harry, I. W. Harry, D. Hartwig, R. K. Hasskew, C.-J. Haster, K. Haughian, F. J. Hayes, J. Healy, A. Heidmann, M. C. Heintze, J. Heinze, J. Heinzel, H. Heitmann, F. Hellman, P. Hello, A. F. Helmling-Cornell, G. Hemming, M. Hendry, I. S. Heng, E. Hennes, J. Hennig, M. H. Hennig, F. Hernandez Vivanco, M. Heurs, S. Hild, P. Hill, A. S. Hines, S. Hochheim, E. Hofgard, D. Hofman, J. N. Hohmann, A. M. Holgado, N. A. Holland, I. J. Hollows, Z. J. Holmes, K. Holt, D. E. Holz, P. Hopkins, C. Horst, J. Hough, E. J. Howell, C. G. Hoy, D. Hoyland, Y. Huang, M. T. Hübner, A. D. Huddart, E. A. Huerta, B. Hughey, V. Hui, S. Husa, S. H. Huttner, B. M. Hutzler, R. Huxford, T. Huynh-Dinh, B. Idzkowski, A. Iess, S. Imperato, H. Inchauspe, C. Ingram, G. Intini, M. Isi, B. R. Iyer, V. JaberianHamedan, T. Jacqmin, S. J. Jadhav, S. P. Jadhav, A. L. James, K. Jani, K. Janssens, N. N. Janthalur, P. Jaranowski, D. Jariwala, R. Jaume, A. C. Jenkins, M. Jeunon, J. Jiang, G. R. Johns, N. K. Johnson-McDaniel, A. W. Jones, D. I. Jones, J. D. Jones, P. Jones, R. Jones, R. J. G. Jonker, L. Ju, J. Junker, C. V. Kalaghatgi, V. Kalogera, B. Kamai, S. Kandhasamy, G. Kang, J. B. Kanner, S. J. Kapadia, D. P. Kapasi, C. Karathanasis, S. Karki, R. Kashyap, M. Kasprzack, W. Kastaun, S. Katsanevas, E. Katsavounidis, W. Katzman, K. Kawabe, F. Kéfélian, D. Keitel, J. S. Key, S. Khadka, F. Y. Khalili, I. Khan, S. Khan, E. A. Khazanov, N. Khetan, M. Khursheed, N. Kijbunchoo, C. Kim, G. J. Kim, J. C. Kim, K. Kim, W. S. Kim, Y.-M. Kim, C. Kimball, P. J. King, M. Kinley-Hanlon, R. Kirchhoff, J. S. Kissel, L. Kleybolte, S. Klimenko, T. D. Knowles, E. Knyazev, P. Koch, S. M. Koehlenbeck, G. Koekoek, S. Koley, M. Kolstein, K. Komori, V. Kondrashov, A. Kontos, N. Koper, M. Korobko, W. Z. Korth, M. Kovalam, D. B. Kozak, C. Krämer, V. Kringel, N. V. Krishnendu, A. Królak, G. Kuehn, A. Kumar, P. Kumar, Rahul Kumar, Rakesh Kumar, K. Kuns, S. Kwang, B. D. Lackey, D. Laghi, E. Lalande, T. L. Lam, A. Lamberts, M. Landry, B. B. Lane, R. N. Lang, J. Lange, B. Lantz, R. K. Lanza, I. La Rosa, A. Lartaux-Vollard, P. D. Lasky, M. Laxen, A. Lazzarini, C. Lazzaro, P. Leaci, S. Leavey, Y. K. Lecoeuche, H. M. Lee, H. W. Lee, J. Lee, K. Lee, J. Lehmann, E. Leon, N. Leroy, N. Letendre, Y. Levin, A. Li, J. Li, K. J. L. Li, T. G. F. Li, X. Li, F. Linde, S. D. Linker, J. N. Linley, T. B. Littenberg, J. Liu, X. Liu, M. Llorens-Monteagudo, R. K. L. Lo, A. Lockwood, L. T. London, A. Longo, M. Lorenzini, V. Loriette, M. Lormand, G. Losurdo, J. D. Lough, C. O. Lousto, G. Lovelace, H. Lück, D. Lumaca, A. P. Lundgren, Y. Ma, R. Macas, M. MacInnis, D. M. Macleod, I. A. O. MacMillan, A. Macquet, I. Magaña Hernandez, F. Magaña-Sandoval, C. Magazzù, R. M. Magee, E. Majorana, I. Maksimovic, S. Maliakal, A. Malik, N. Man, V. Mandic, V. Mangano, G. L. Mansell, M. Manske, M. Mantovani, M. Mapelli, F. Marchesoni, F. Marion, S. Márka, Z. Márka, C. Markakis, A. S. Markosyan, A. Markowitz, E. Maros, A. Marquina, S. Marsat, F. Martelli, I. W. Martin, R. M. Martin, M. Martinez, V. Martinez, D. V. Martynov, H. Masalehdan, K. Mason, E. Massera, A. Masserot, T. J. Massinger, M. Masso-Reid, S. Mastrogiovanni, A. Matas, M. Mateu-Lucena, F. Matichard, M. Matiushechkina, N. Mavalvala, E. Maynard, J. J. McCann, R. McCarthy, D. E. McClelland, S. McCormick, L. McCuller, S. C. McGuire, C. McIsaac, J. McIver, D. J. McManus, T. McRae, S. T. McWilliams, D. Meacher, G. D. Meadors, M. Mehmet, A. K. Mehta, A. Melatos, D. A. Melchor, G. Mendell, A. Menendez-Vazquez, R. A. Mercer, L. Mereni, K. Merfeld, E. L. Merilh, J. D. Merritt, M. Merzougui, S. Meshkov, C. Messenger, C. Messick, R. Metzdorff, P. M. Meyers, F. Meylahn, A. Mhaske, A. Miani, H. Miao, I. Michaloliakos, C. Michel, H. Middleton, L. Milano, A. L. Miller, M. Millhouse, J. C. Mills, E. Milotti, M. C. Milovich-Goff, O. Minazzoli, Y. Minenkov, Ll. M. Mir, A. Mishkin, C. Mishra, T. Mistry, S. Mitra, V. P. Mitrofanov, G. Mitselmakher, R. Mittleman, G. Mo, K. Mogushi, S. R. P. Mohapatra, S. R. Mohite, I. Molina, M. Molina-Ruiz, M. Mondin, M. Montani, C. J. Moore, D. Moraru, F. Morawski, G. Moreno, S. Morisaki, B. Mours, C. M. Mow-Lowry, S. Mozzon, F. Muciaccia, Arunava Mukherjee, D. Mukherjee, Soma Mukherjee, Subroto Mukherjee, N. Mukund, A. Mullavey, J. Munch, E. A. Muñiz, P. G. Murray, S. L. Nadji, A. Nagar, I. Nardecchia, L. Naticchioni, R. K. Nayak, B. F. Neil, J. Neilson, G. Nelemans, T. J. N. Nelson, M. Nery, A. Neunzert, A. H. Nitz, K. Y. Ng, S. Ng, C. Nguyen, P. Nguyen, T. Nguyen, S. A. Nichols, S. Nissanke, F. Nocera, M. Noh, C. North, D. Nothard, L. K. Nuttall, J. Oberling, B. D. O’Brien, J. O’Dell, G. Oganesyan, G. H. Ogin, J. J. Oh, S. H. Oh, F. Ohme, H. Ohta, M. A. Okada, C. Olivetto, P. Oppermann, R. J. Oram, B. O’Reilly, R. G. Ormiston, L. F. Ortega, R. O’Shaughnessy, S. Ossokine, C. Osthelder, D. J. Ottaway, H. Overmier, B. J. Owen, A. E. Pace, G. Pagano, M. A. Page, G. Pagliaroli, A. Pai, S. A. Pai, J. R. Palamos, O. Palashov, C. Palomba, H. Pan, P. K. Panda, T. H. Pang, C. Pankow, F. Pannarale, B. C. Pant, F. Paoletti, A. Paoli, A. Paolone, W. Parker, D. Pascucci, A. Pasqualetti, R. Passaquieti, D. Passuello, M. Patel, B. Patricelli, E. Payne, T. C. Pechsiri, M. Pedraza, M. Pegoraro, A. Pele, S. Penn, A. Perego, C. J. Perez, C. Périgois, A. Perreca, S. Perriès, J. Petermann, D. Petterson, H. P. Pfeiffer, K. A. Pham, K. S. Phukon, O. J. Piccinni, M. Pichot, M. Piendibene, F. Piergiovanni, L. Pierini, V. Pierro, G. Pillant, F. Pilo, L. Pinard, I. M. Pinto, K. Piotrzkowski, M. Pirello, M. Pitkin, E. Placidi, W. Plastino, C. Pluchar, R. Poggiani, E. Polini, D. Y. T. Pong, S. Ponrathnam, P. Popolizio, E. K. Porter, A. Poverman, J. Powell, M. Pracchia, A. K. Prajapati, K. Prasai, R. Prasanna, G. Pratten, T. Prestegard, M. Principe, G. A. Prodi, L. Prokhorov, P. Prosposito, L. Prudenzi, A. Puecher, M. Punturo, F. Puosi, P. Puppo, M. Pürrer, H. Qi, V. Quetschke, P. J. Quinonez, R. Quitzow-James, F. J. Raab, G. Raaijmakers, H. Radkins, N. Radulesco, P. Raffai, H. Rafferty, S. X. Rail, S. Raja, C. Rajan, B. Rajbhandari, M. Rakhmanov, K. E. Ramirez, T. D. Ramirez, A. Ramos-Buades, J. Rana, K. Rao, P. Rapagnani, U. D. Rapol, B. Ratto, V. Raymond, M. Razzano, J. Read, T. Regimbau, L. Rei, S. Reid, D. H. Reitze, P. Rettegno, F. Ricci, C. J. Richardson, J. W. Richardson, L. Richardson, P. M. Ricker, G. Riemenschneider, K. Riles, M. Rizzo, N. A. Robertson, F. Robinet, A. Rocchi, J. A. Rocha, S. Rodriguez, R. D. Rodriguez-Soto, L. Rolland, J. G. Rollins, V. J. Roma, M. Romanelli, R. Romano, C. L. Romel, A. Romero, I. M. Romero-Shaw, J. H. Romie, S. Ronchini, C. A. Rose, D. Rose, K. Rose, M. J. B. Rosell, D. Rosińska, S. G. Rosofsky, M. P. Ross, S. Rowan, S. J. Rowlinson, Santosh Roy, Soumen Roy, P. Ruggi, K. Ryan, S. Sachdev, T. Sadecki, J. Sadiq, M. Sakellariadou, O. S. Salafia, L. Salconi, M. Saleem, A. Samajdar, E. J. Sanchez, J. H. Sanchez, L. E. Sanchez, N. Sanchis-Gual, J. R. Sanders, L. Sandles, K. A. Santiago, E. Santos, T. R. Saravanan, N. Sarin, B. Sassolas, B. S. Sathyaprakash, O. Sauter, R. L. Savage, V. Savant, D. Sawant, S. Sayah, D. Schaetzl, P. Schale, M. Scheel, J. Scheuer, A. Schindler-Tyka, P. Schmidt, R. Schnabel, R. M. S. Schofield, A. Schönbeck, E. Schreiber, B. W. Schulte, B. F. Schutz, O. Schwarm, E. Schwartz, J. Scott, S. M. Scott, M. Seglar-Arroyo, E. Seidel, D. Sellers, A. S. Sengupta, N. Sennett, D. Sentenac, V. Sequino, A. Sergeev, Y. Setyawati, T. Shaffer, M. S. Shahriar, S. Sharifi, A. Sharma, P. Sharma, P. Shawhan, H. Shen, M. Shikauchi, R. Shink, D. H. Shoemaker, D. M. Shoemaker, K. Shukla, S. ShyamSundar, M. Sieniawska, D. Sigg, L. P. Singer, D. Singh, N. Singh, A. Singha, A. Singhal, A. M. Sintes, V. Sipala, V. Skliris, B. J. J. Slagmolen, T. J. Slaven-Blair, J. Smetana, J. R. Smith, R. J. E. Smith, S. N. Somala, E. J. Son, K. Soni, S. Soni, B. Sorazu, V. Sordini, F. Sorrentino, N. Sorrentino, R. Soulard, T. Souradeep, E. Sowell, A. P. Spencer, M. Spera, A. K. Srivastava, V. Srivastava, K. Staats, C. Stachie, D. A. Steer, J. Steinhoff, M. Steinke, J. Steinlechner, S. Steinlechner, D. Steinmeyer, S. P. Stevenson, G. Stolle-McAllister, D. J. Stops, M. Stover, K. A. Strain, G. Stratta, A. Strunk, R. Sturani, A. L. Stuver, J. Südbeck, S. Sudhagar, V. Sudhir, H. G. Suh, T. Z. Summerscales, H. Sun, L. Sun, S. Sunil, A. Sur, J. Suresh, P. J. Sutton, B. L. Swinkels, M. J. Szczepańczyk, M. Tacca, S. C. Tait, C. Talbot, A. J. Tanasijczuk, D. B. Tanner, D. Tao, A. Tapia, E. N. Tapia San Martin, J. D. Tasson, R. Taylor, R. Tenorio, L. Terkowski, M. P. Thirugnanasambandam, L. M. Thomas, M. Thomas, P. Thomas, J. E. Thompson, S. R. Thondapu, K. A. Thorne, E. Thrane, Shubhanshu Tiwari, Srishti Tiwari, V. Tiwari, K. Toland, A. E. Tolley, M. Tonelli, Z. Tornasi, A. Torres-Forné, C. I. Torrie, I. Tosta e Melo, D. Töyrä, A. T. Tran, A. Trapananti, F. Travasso, G. Traylor, M. C. Tringali, A. Tripathee, A. Trovato, R. J. Trudeau, D. S. Tsai, K. W. Tsang, M. Tse, R. Tso, L. Tsukada, D. Tsuna, T. Tsutsui, M. Turconi, A. S. Ubhi, R. P. Udall, K. Ueno, D. Ugolini, C. S. Unnikrishnan, A. L. Urban, S. A. Usman, A. C. Utina, H. Vahlbruch, G. Vajente, A. Vajpeyi, G. Valdes, M. Valentini, V. Valsan, N. van Bakel, M. van Beuzekom, J. F. J. van den Brand, C. Van Den Broeck, D. C. Vander-Hyde, L. van der Schaaf, J. V. van Heijningen, M. Vardaro, A. F. Vargas, V. Varma, S. Vass, M. Vasúth, A. Vecchio, G. Vedovato, J. Veitch, P. J. Veitch, K. Venkateswara, J. Venneberg, G. Venugopalan, D. Verkindt, Y. Verma, D. Veske, F. Vetrano, A. Viceré, A. D. Viets, A. Vijaykumar, V. Villa-Ortega, J.-Y. Vinet, S. Vitale, T. Vo, H. Vocca, C. Vorvick, S. P. Vyatchanin, A. R. Wade, L. E. Wade, M. Wade, R. C. Walet, M. Walker, G. S. Wallace, L. Wallace, S. Walsh, J. Z. Wang, S. Wang, W. H. Wang, Y. F. Wang, R. L. Ward, J. Warner, M. Was, N. Y. Washington, J. Watchi, B. Weaver, L. Wei, M. Weinert, A. J. Weinstein, R. Weiss, F. Wellmann, L. Wen, P. Weßels, J. W. Westhouse, K. Wette, J. T. Whelan, D. D. White, L. V. White, B. F. Whiting, C. Whittle, D. M. Wilken, D. Williams, M. J. Williams, A. R. Williamson, J. L. Willis, B. Willke, D. J. Wilson, M. H. Wimmer, W. Winkler, C. C. Wipf, G. Woan, J. Woehler, J. K. Wofford, I. C. F. Wong, J. Wrangel, J. L. Wright, D. S. Wu, D. M. Wysocki, L. Xiao, H. Yamamoto, L. Yang, Y. Yang, Z. Yang, M. J. Yap, D. W. Yeeles, A. Yoon, Hang Yu, Haocun Yu, S. H. R. Yuen, A. Zadrożny, M. Zanolin, T. Zelenova, J.-P. Zendri, M. Zevin, J. Zhang, L. Zhang, R. Zhang, T. Zhang, C. Zhao, G. Zhao, Y. Zheng, M. Zhou, Z. Zhou, X. J. Zhu, A. B. Zimmerman, Y. Zlochower, M. E. Zucker, and J. Zweizig

Subjects
Physics, QC1-999
Abstract

We report on gravitational-wave discoveries from compact binary coalescences detected by Advanced LIGO and Advanced Virgo in the first half of the third observing run (O3a) between 1 April 2019 15∶00 UTC and 1 October 2019 15∶00 UTC. By imposing a false-alarm-rate threshold of two per year in each of the four search pipelines that constitute our search, we present 39 candidate gravitational-wave events. At this threshold, we expect a contamination fraction of less than 10%. Of these, 26 candidate events were reported previously in near-real time through gamma-ray coordinates network notices and circulars; 13 are reported here for the first time. The catalog contains events whose sources are black hole binary mergers up to a redshift of approximately 0.8, as well as events whose components cannot be unambiguously identified as black holes or neutron stars. For the latter group, we are unable to determine the nature based on estimates of the component masses and spins from gravitational-wave data alone. The range of candidate event masses which are unambiguously identified as binary black holes (both objects ≥3 M_{⊙}) is increased compared to GWTC-1, with total masses from approximately 14 M_{⊙} for GW190924_021846 to approximately 150 M_{⊙} for GW190521. For the first time, this catalog includes binary systems with significantly asymmetric mass ratios, which had not been observed in data taken before April 2019. We also find that 11 of the 39 events detected since April 2019 have positive effective inspiral spins under our default prior (at 90% credibility), while none exhibit negative effective inspiral spin. Given the increased sensitivity of Advanced LIGO and Advanced Virgo, the detection of 39 candidate events in approximately 26 weeks of data (approximately 1.5 per week) is consistent with GWTC-1.

Published
2021
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13. Validez del dispositivo inercial WIMU PRO para el registro de la frecuencia cardiaca en un test de campo

Author

I. Molina-Carmona, C. Gómez-Carmona, A. Bastida-Castillo, and J. Pino-Ortega

Subjects
fútbol, dispositivo inercial, esfuerzos intermitentes de alta intensidad, Sports, GV557-1198.995
Abstract

Los avances tecnológicos han contribuido a la mejora de la colección de datos fisiológicos y cinemáticos con relación a la competición y los entrenamientos. Dispositivos inerciales tales como WIMUPROTM (RealTrack Systems, Almería, España) compuesto por diferentes sensores (cuatro acelerómetros, dos giróscopos, un magnetómetro, un chip GNSS para posicionamiento global mediante satélite, un chip UWB para posicionamiento por radiofrecuencia de onda corta en deportes indoor, receptor de Ant+ y Bluetooth, entre otros)se utilizan dentro de una variedad de situaciones deportivas. Es importante conocer la validez y precisión del dato de dichas mediciones ya que se utilizan en contextos reales del juego. Objetivo. Evaluar la validez del dispositivo inercial WIMU PROTM para registrar la variable frecuencia cardiaca (FC) en relación con un dispositivo validado como es Polar Team 2®.Participantes. 15 jugadores de fútbol de categoría cadete participaron voluntariamente en este estudio(edad:15,40 ± 0,50 años, altura:169,26 ± 0,08 cm, peso:62,00 ± 12,32 kg). Procedimiento. Los individuos que componen la muestra llevaron a cabo el test RSA (adaptado de Bangsbo 2008) el cual consta de 7 sprints de 30 metros con una recuperación activa entre ellos de 20 segundos, el cual simula las exigencias reales de competición en fútbol. Resultados.Se encontró una correlación muy alta entre los datos obtenidos por el registro del dispositivo WIMU PROTM y los realizados por el dispositivo Polar Team 2® (r2=.958, p

Published
2018
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14. Calibrated Monolithically Integrated 90 $^{\circ} $ Downconverter for Colorless Operation in the C+L Band

Author

P. J. Reyes-Iglesias, A. Ortega-Monux, and I. Molina-Fernandez

Subjects
Coherent communication, fiber optics systems, integrated photonic systems, waveguide devices, Applied optics. Photonics, TA1501-1820, Optics. Light, QC350-467
Abstract

We propose a 90° hybrid-based monolithically integrated coherent receiver suitable for colorless operation in the complete C- and L-band (1530-1625 nm). In-phase and quadrature (IQ) signal components are obtained from a calibrated analog IQ recovery circuit, which adequately combines all the four photocurrents at the output of the 90° hybrid nearly cancelling the baseband interference from the self-beating of adjacent wavelength division multiplexing channels. We numerically demonstrate that the proposed downconverter supports colorless reception of 128 channels with 16-quadrature amplitude modulation at 112 Gbps in the C+L band. Aside from this, this receiver exhibits a noticeable dynamic range, thereby not requiring a variable optical attenuator on the signal path, and it is pretty robust under realistic fabrication errors of the optoelectronic chip.

Published
2015
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15. A Comprehensive Usability Measurement Tool for m-Learning Applications

Author

Christian X. Navarro-Cota, Ana I. Molina, Miguel A. Redondo, and Carmen Lacave

Abstract

Contribution: This article describes the process used to create a questionnaire to evaluate the usability of mobile learning applications (CECAM). The questionnaire includes specific questions to assess user interface usability and pedagogical usability. Background: Nowadays, mobile applications are expanding rapidly and are commonly used in educational institutions to support the learning and teaching process. But the possible deficient usability could decrease the utility of learning activities and the student's motivation. Therefore, careful planning and design by the developer are required, along with a usability evaluation of the applications. Research Questions: How could an instrument be developed to evaluate the usability of m-learning applications that combine technical and pedagogical aspects? How can the quality of the developed instrument be determined? Methodology: A structured questionnaire was created like a measuring tool to evaluate and design m-learning applications. Different statistical techniques, including reliability and validity assessments, were employed to evaluate the quality of the instrument, which is determined through the calibration of the CECAM survey. Findings: After the validity analysis of the questionnaire, a scale with 56 items was obtained, with an alpha reliability coefficient of 0.911 (an excellent measuring scale). It pretends to be used by teachers to design or evaluate m-learning applications, improve their usability, and enhance the students' learning experience.

Published
2024
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16. Refractive Index Engineering With Subwavelength Gratings in Silicon Microphotonic Waveguides

Author

J. H. Schmid, P. Cheben, P. J. Bock, R. Halir, J. Lapointe, S. Janz, A. Delage, A. Densmore, J.-M. Fedeli, T. J. Hall, B. Lamontagne, R. Ma, I. Molina-Fernandez, and D.-X. Xu

Subjects
Silicon photonics, nanophotonics, subwavelength gratings (SWGs), waveguides, Applied optics. Photonics, TA1501-1820, Optics. Light, QC350-467
Abstract

In this review, we summarize and discuss our recent studies of subwavelength grating (SWG) structures for engineering the refractive index of silicon microphotonic waveguides. The SWG effect allows control of the effective refractive index of a waveguide core over a range spanning the values of the cladding material and silicon by lithographic patterning. We demonstrate this effect with the example of segmented photonic wire waveguides, which are shown to exhibit low propagation loss, and can be used to make highly efficient waveguide crossings and in-plane fiber–chip coupling structures. Other applications of SWG structures in silicon photonic waveguide devices include surface grating couplers with enhanced performance and simplified fabrication requirements, as well as a novel curved waveguide sidewall grating microspectrometer, in which an SWG structure fulfills a dual purpose by acting as an effective slab waveguide for diffracted light and as a lateral cladding for a channel waveguide.

Published
2011
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17. Intraslab Mexican earthquakes of 27 April 2009 (Mw5.8) and 22 May 2009 (Mw5.6): a source and ground motion study

Author

UNAM Seismology group, Xyoli Pérez-Campos, Singh Singh Shri Krishna, Arturo Iglesias Mendoza, L Alcántara, M Ordaz, Denis Legrand, L. A. Aguilar, D. Almora, M. Ambriz, M. Ayala, C. Cárdenas, G. Castro, J. l Cruz, R. Delgado, J. Estrada, S.I. Franco-Sánchez, M.A. Macías, I. Molina, F. Navarro, C. Pérez, J. Pérez, A. Quezada, Luis Quintanar Robles, L.E. Rodríguez, A.L. Ruiz, H. E. Sandoval, M. Torres, C. Valdés-González, R Vázquez, JM. Velasco, J. Velázquez, and M. Velázquez

Subjects
sismos intraplaca, geometría de la placa, energía radiada, movimiento del terreno, Geophysics. Cosmic physics, QC801-809
Abstract

Dos tipos de sismos intraplaca en la placa de Cocos que subduce debajo de la placa Norte America ocurren en Guerrero, México, y áreas adyacentes: (A) inversos de gran echado y (B) de fallamiento normal. Los de tipo A se localizan a ~10-35 km de la costa, a una profundidad de ~35 km, y revelan compresión en la dirección del echado de la placa, probablemente causada por su desdoblamiento. Los de tipo B son ligeramente más profundos que los del tipo A cuando ocurren cerca de la costa, pero si ocurren más adentro del continente, donde la placa se vuelve horizontal, alcanzan profundidades de 40-50 km. Estos eventos revelan extensión en la placa subducida orientada en la dirección de su echado. El análisis de los sismos del 27 de abril y del 22 de mayo de 2009 revela que se trata de eventos intraplaca en la placa de Cocos subducida del tipo A y B, respectivamente. Los espectros de fuente obtenidos a partir de datos locales y regionales dan una caída de esfuerzos de Brune, Δσ, de ~49 y 34 MPa, respectivamente, un poco mayores que la mediana de Δσ de 30 MPa reportada previamente para sismos intraplaca mexicanos. Nuestras estimaciones de energía radiada, ER, son 3.55x1013 J y 2.29x1013 J, lo que arroja un cociente ER/M0 de 5.63x10-5 y 6.54x10-5, y un esfuerzo aparente, σa, de 3.9 MPa y 4.6 MPa, respectivamente (correspondientes al M0 reportado en el catálogo Global de CMT), valores razonables para sismos intraplaca. Las aceleraciones máximas del terreno (PGA), como una función de la distancia están en buen acuerdo con relaciones de atenuación previamente obtenidas para sismos intraplaca mexicanos. Los movimientos del terreno en el Valle de México generados por sismos intraplaca son más ricos en altas frecuencias en comparación con aquéllos de eventos interplaca, especialmente en la zona dura. Esto refleja tanto una naturaleza más energética de las fuentes intraplaca como una distancia más cercana a la fuente de muchos de estos sismos. Los resultados obtenidos en este estudio nos dan confianza en nuestro conocimiento de la naturaleza de las fuentes intraplaca y nuestra habilidad de estimar movimientos fuertes para eventos futuros. doi: https://doi.org/10.22201/igeof.00167169p.2010.49.3.111

Published
2010
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19. Metodología de diseño, observación y cálculo de redes geodésicas interiores en túneles de ferrocarril de alta velocidad

Author

J. Velasco, T. Herrero, I. Molina, J. López, E. Pérez-Martín, and J. Prieto

Subjects
ferrocarriles, túneles, geodesia, redes geodésicas, simulación, Architecture, NA1-9428, Building construction, TH1-9745
Abstract

El guiado de las Tuneladoras durante su avance debe apoyarse en los puntos determinados inmediatamente detrás de ellas. Conseguir las precisiones requeridas presentaría algunas dificultades en condiciones normales con respecto al exterior, pero en el interior de un túnel se plantean ciertos factores que ensombrecen el panorama. El más importante y difícil de tratar es el de la refracción lateral. El diseño de redes interiores es uno de los principales problemas, desde el punto de vista geodésico y topográfico, el cual tiene unas características tales que todos los textos de topografía de precisión aconsejan evitar. Con estas redes se va guiando la tuneladora y en ningún momento dicha red vuelve a tener comprobación sobre otros puntos de control. A medida que la red va avanzando, las precisiones obtenidas de sus coordenadas van empeorando de forma exponencial. Este trabajo establece una metodología para el diseño de redes planimétricas interiores.

Published
2015
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23. Six-Port-Based Architecture for Phase Noise Measurement in the UWB Band

Author

J. M. Ávila-Ruiz, A. Moscoso-Mártir, E. Durán-Valdeiglesias, L. Moreno-Pozas, J. de-Oliva-Rubio, and I. Molina-Fernández

Subjects
Computer engineering. Computer hardware, TK7885-7895
Abstract

A six-port-based frequency discriminator for phase noise measurement is proposed. This circuit makes use of a delay line discriminator configuration, thus not requiring reference oscillator. Furthermore, the use of a six-port network allows an extremely simple and completely passive solution well suited for low power oscillator measurement. A detailed study of the architecture is performed including the system noise sources. Besides, a prototype of the proposed six-port based delay line frequency discriminator is evaluated. Phase noise measurements of a commercial RF VCO are performed and compared with the results obtained with commercial metrology equipment with good agreement.

Published
2014
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26. Large Format Additive Manufacturing in Furniture Design with Novel Cork Based Polymeric Materials

Author

Nieto, Daniel Moreno, Pintos, Pedro Burgos, Sánchez, Daniel Moreno, Rubio, Sergio I. Molina, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Haddar, Mohamed, Editorial Board Member, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Marín Granados, Manuel D., editor, Mirálbes Buil, Ramón, editor, and de-Cózar-Macías, Oscar D., editor

Published
2023
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28. 2024 Latin American Society of Hypertension guidelines on the management of arterial hypertension and related comorbidities in Latin America.

Author

Sánchez, Ramiro, Coca, Antonio, de Salazar, Dora I. Molina, Alcocer, Luis, Aristizabal, Dagnovar, Barbosa, Eduardo, Brandao, Andrea A., Diaz-Velazco, Margarita E., Hernández-Hernández, Rafael, López-Jaramillo, Patricio, López-Rivera, Jesús, Ortellado, José, Parra-Carrillo, José, Parati, Gianfranco, Peñaherrera, Ernesto, Ramirez, Agustín J., Sebba-Barroso, Weimar K., Valdez, Osiris, Wyss, Fernando, and Heagerty, Anthony

Published
2025
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32. Temas de Derecho Minero y Energético

Author

Ana Milena Vásquez Domínguez, Marina Motta Benevides Gadelha, Margarita Ricaurte Rueda, Diana Carolina Sánchez Zapata, Adriana María Sanín Vélez, Clara Inés Atehortúa Arredondo, Ana Restrepo Londoño, Laura Juanita Villanueva Marroquín, Sebastián Cabrales Villalba, Arenas A I Molina, C Guzmán E Ávila, Milton Fernando Montoya Pardo

Published
2022

33. Subwavelength-Engineered Metamaterial Devices for Integrated Photonics.

Author

Pavel Cheben, Jens H. Schmid, Pablo Ginel-Moreno, Shahrzad Khajavi, R. Korcek, W. Fraser, D. Sirmaci, Alejandro Fernández Hinestrosa, Jose M. Luque-González, Daniel Pereira-Martín, Alejandro Sánchez-Postigo, Abdelfettah Hadij-ElHouati, Daniel Benedikovic, Alejandro Ortega-Moñux, J. Gonzalo Wangüemert-Pérez, I. Molina Fernandez, Robert Halir, Winnie N. Ye, Daniele Melati, Carlos Alonso-Ramos, David González-Andrade, Laurent Vivien, I. Staude, J. Zhang, Maziyar Milanizadeh, Dan-Xia Xu, Yuri Grinberg, Ross Cheriton, Siegfried Janz, S. Wang, Martin Vachon, Milan Dado, R. Fernández de Cabo, and Aitor V. Velasco

Published
2023
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40. Apolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab

Author

Hagström, Emil, Steg, P. Gabriel, Szarek, Michael, Bhatt, Deepak L., Bittner, Vera A., Danchin, Nicolas, Diaz, Rafael, Goodman, Shaun G., Harrington, Robert A., Jukema, J. Wouter, Liberopoulos, Evangelos, Marx, Nikolaus, McGinniss, Jennifer, Manvelian, Garen, Pordy, Robert, Scemama, Michel, White, Harvey D., Zeiher, Andreas M., Schwartz, Gregory G., Schwartz, Gregory G., Bhatt, Deepak L., Bittner, Vera A., Diaz, Rafael, Goodman, Shaun G., Harrington, Robert A., Jukema, J. Wouter, Szarek, Michael, White, Harvey D., Zeiher, Andreas M., Tricoci, Pierluigi, Roe, Matthew T., Mahaffey, Kenneth W., Edelberg, Jay M., Hanotin, Corinne, Lecorps, Guillaume, Moryusef, Angèle, Pordy, Robert, Sasiela, William J., Tamby, Jean-François, Diaz, Rafael, Aylward, Philip E, Drexel, Heinz, Sinnaeve, Peter, Dilic, Mirza, Lopes, Renato D., Gotcheva, Nina N, Goodman, Shaun G., Prieto, Juan-Carlos, Yong, Huo, López-Jaramillo, Patricio, Pećin, Ivan, Reiner, Zeljko, Ostadal, Petr, Poulsen, Steen Hvitfeldt, Viigimaa, Margus, Nieminen, Markku S, Danchin, Nicolas, Chumburidze, Vakhtang, Marx, Nikolaus, Liberopoulos, Evangelos, Carlos, Pablo, Valdovinos, Montenegro, Tse, Hung-Fat, Kiss, Robert Gabor, Xavier, Denis, Zahger, Doron, Valgimigli, Marco, Kimura, Takeshi, Kim, Hyo Soo, Kim, Sang-Hyun, Erglis, Andrejs, Laucevicius, Aleksandras, Kedev, Sasko, Yusoff, Khalid, Ramos López, Gabriel Arturo, Alings, Marco, White, Harvey D., Halvorsen, Sigrun, Correa Flores, Roger M, Sy, Rody G., Budaj, Andrzej, Morais, Joao, Dorobantu, Maria, Karpov, Yuri, Ristic, Arsen D., Chua, Terrance, Murin, Jan, Fras, Zlatko, Dalby, Anthony J, Tuñón, José, de Silva, H. Asita, Hagström, Emil, Landmesser, Ulf, Müller, Christian, Chiang, Chern-En, Sritara, Piyamitr, Guneri, Sema, Parkhomenko, Alexander, Ray, Kausik K., Moriarty, Patrick M., Roe, Matthew T., Vogel, Robert, Chaitman, Bernard, Kelsey, Sheryl F., Olsson, Anders G., Rouleau, Jean-Lucien, Simoons, Maarten L., Alexander, Karen, Meloni, Chiara, Rosenson, Robert, Sijbrands, Eric J.G., Tricoci, Pierluigi, Alexander, John H., Armaganijan, Luciana, Bagai, Akshay, Bahit, Maria Cecilia, Brennan, J. Matthew, Clifton, Shaun, DeVore, Adam D., Deloatch, Shalonda, Dickey, Sheila, Dombrowski, Keith, Ducrocq, Grégory, Eapen, Zubin, Endsley, Patricia, Eppinger, Arleen, Harrison, Robert W., Hess, Connie Ng, Hlatky, Mark A., Jordan, Joseph Dedrick, Knowles, Joshua W., Kolls, Bradley J., Kong, David F., Leonardi, Sergio, Lillis, Linda, Lopes, Renato D., Maron, David J., Mahaffey, Kenneth W., Marcus, Jill, Mathews, Robin, Mehta, Rajendra H., Mentz, Robert J., Moreira, Humberto Graner, Patel, Chetan B., Pereira, Sabrina Bernardez, Perkins, Lynn, Povsic, Thomas J., Puymirat, Etienne, Roe, Matthew T., Jones, William Schuyler, Shah, Bimal R., Sherwood, Matthew W., Stringfellow, Kenya, Sujjavanich, Darin, Toma, Mustafa, Trotter, Charlene, van Diepen, Sean F.P., Wilson, Matthew D., Tze-Kay Yan, Andrew, Schiavi, Lilia B, Garrido, Marcelo, Alvarisqueta, Andrés F, Sassone, Sonia A, Bordonava, Anselmo P, Alves De Lima, Alberto E, Schmidberg, Jorge M, Duronto, Ernesto A, Caruso, Orlando C, Novaretto, Leonardo P, Hominal, Miguel Angel, Montaña, Oscar R, Caccavo, Alberto, Gomez Vilamajo, Oscar A, Lorenzatti, Alberto J, Cartasegna, Luis R, Paterlini, Gustavo A, Mackinnon, Ignacio J, Caime, Guillermo D, Amuchastegui, Marcos, Salomone, Oscar, Codutti, Oscar R, Jure, Horacio O, Bono, Julio OE, Hrabar, Adrian D, Vallejos, Julio A, Ahuad Guerrero, Rodolfo A, Novoa, Federico, Patocchi, Cristian A, Zaidman, Cesar J, Giuliano, Maria E, Dran, Ricardo D, Vico, Marisa L, Carnero, Gabriela S, Guzman, Pablo N, Medrano Allende, Juan C, Garcia Brasca, Daniela F, Bustamante Labarta, Miguel H, Nani, Sebastian, Blumberg, Eduardo DS, Colombo, Hugo R, Liberman, Alberto, Fuentealba, Victorino, Luciardi, Hector L, Waisman, Gabriel D, Berli, Mario A, Garcia Duran, Ruben O, Cestari, Horacio G, Luquez, Hugo A, Giordano, Jorge A, Saavedra, Silvia S, Zapata, Gerardo, Costamagna, Osvaldo, Llois, Susana, Waites, Jonathon H, Collins, Nicholas, Soward, Allan, Aylward, Philip E, Hii, Chris LS, Aylward, Philip E, Shaw, James, Arstall, Margaret A, Horowitz, John, Ninio, Daniel, Rogers, James F, Colquhoun, David, Oqueli Flores, Romulo E, Roberts-Thomson, Philip, Raffel, Owen, Lehman, Sam J, Aroney, Constantine, Coverdale, Steven GM, Garrahy, Paul J, Starmer, Gregory, Sader, Mark, Carroll, Patrick A, Dick, Ronald, Zweiker, Robert, Hoppe, Uta, Drexel, Heinz, Huber, Kurt, Berger, Rudolf, Delle-Karth, Georg, Frey, Bernhard, Weidinger, Franz, Faes, Dirk, Hermans, Kurt, Pirenne, Bruno, Leone, Attilio, Hoffer, Etienne, Sinnaeve, Peter, Vrolix, Mathias CM, Wolf, Luc De, Wollaert, Bart, Castadot, Marc, Dujardin, Karl, Beauloye, Christophe, Vervoort, Geert, Striekwold, Harry, Convens, Carl, Roosen, John, Barbato, Emanuele, Claeys, Marc, Cools, Frank, Terzic, Ibrahim, Barakovic, Fahir, Midzic, Zlatko, Pojskic, Belma, Fazlibegovic, Emir, Dilic, Mirza, Durak-Nalbantic, Azra, Kulić, Mehmed, Vulic, Dusko, Muslibegovic, Adis, Goronja, Boris, Reis, Gilmar, Sousa, Luciano, Nicolau, Jose C, Giorgeto, Flavio E, Silva, Ricardo P, Maia, Lilia Nigro, Rech, Rafael, Rossi, Paulo RF, Cerqueira, Maria José AG, Duda, Norberto, Kalil, Renato, Kormann, Adrian, Abrantes, José Antonio M, Filho, Pedro Pimentel, Soggia, Ana Priscila, de Santos, Mayler ON, Neuenschwander, Fernando, Bodanese, Luiz C, Michalaros, Yorghos L, Eliaschewitz, Freddy G, Vidotti, Maria H, Leaes, Paulo E, Botelho, Roberto V, Kaiser, Sergio, Manenti, Euler Roberto F Fernandes, Precoma, Dalton B, Moura Jorge, Jose C, Silva, Pedro, Silveira, Jose A, Saporito, Wladmir, Neto, Jose A Marin, Feitosa, Gilson S, Ritt, Luiz Eduardo F, de Souza, Juliana A, Costa, Fernando, Souza, Weimar KSB, Reis, Helder JL, Lopes, Renato D., Machado, Leandro, Aidar Ayoub, José Carlos, Todorov, Georgi V, Nikolov, Fedya P, Velcheva, Elena S, Tzekova, Maria L, Benov, Haralambi O, Petranov, Stanislav L, Tumbev, Haralin S, Shehova-Yankova, Nina S, Markov, Dimitar T, Raev, Dimitar H, Mollov, Mihail N, Kichukov, Kostadin N, Ilieva- Pandeva, Katya A, Gotcheva, Nina N, Ivanova, Raya, Gospodinov, Maryana, Mincheva, Valentina M, Lazov, Petar V, Dimov, Bojidar I, Senaratne, Manohara, Stone, James, Kornder, Jan, Pearce, Stephen, Dion, Danielle, Savard, Daniel, Pesant, Yves, Pandey, Amritanshu, Robinson, Simon, Gosselin, Gilbert, Vizel, Saul, Hoag, Gordon, Bourgeois, Ronald, Morisset, Anne, Sabbah, Eric, Sussex, Bruce, Kouz, Simon, MacDonald, Paul, Diaz, Ariel, Michaud, Nicolas, Fell, David, Leung, Raymond, Vuurmans, Tycho, Lai, Christopher, Nigro, Frank, Davies, Richard, Nogareda, Gustavo, Vijayaraghavan, Ram, Ducas, John, Lepage, Serge, Mehta, Shamir, Cha, James, Dupuis, Robert, Fong, Peter, Lutchmedial, Sohrab, Rodes-Cabau, Josep, Fadlallah, Hussein, Cleveland, David, Huynh, Thao, Bata, Iqbal, Hameed, Adnan, Pincetti, Cristian, Potthoff, Sergio, Prieto, Juan C, Acevedo, Monica, Aguirre, Arnoldo, Vejar, Margarita, Yañez, Mario, Araneda, Guillermo, Fernandez, Mauricio, Perez, Luis, Varleta, Paola, Florenzano, Fernando, Huidobro, Laura, Raffo, Carlos A, Olivares, Claudia, Nahuelpan, Leonardo, Montecinos, Humberto, Chen, Jiyan, Dong, Yugang, Huang, Weijian, Wang, Jianzhong, Huang, Shi’An, Yao, Zhuhua, Li, Xiang, Cui, Lan, Lin, Wenhua, Sun, Yuemin, Wang, Jingfeng, Li, Jianping, Zhang, Xuelian, Zhu, Hong, Chen, Dandan, Huang, Lan, Dong, Shaohong, Su, Guohai, Xu, Biao, Su, Xi, Cheng, Xiaoshu, Lin, Jinxiu, Zong, Wenxia, Li, Huanming, Feng, Yi, Xu, Dingli, Yang, Xinchun, Ke, Yuannan, Lin, Xuefeng, Zhang, Zheng, Zheng, Zeqi, Luo, Zhurong, Chen, Yundai, Ding, Chunhua, Zhong, Yi, Zheng, Yang, Li, Xiaodong, Peng, Daoquan, Zhao, Shuiping, Li, Ying, Liu, Xuebo, Wei, Meng, Liu, Shaowen, Yu, Yihua, Qu, Baiming, Jiang, Weihong, Zhou, Yujie, Zhao, Xingsheng, Yuan, Zuyi, Guo, Ying, Xu, Xiping, Shi, Xubo, Ge, Junbo, Fu, Guosheng, Bai, Feng, Fang, Weiyi, Shou, Xiling, Yang, Xiangjun, Wang, Jian’An, Xiang, Meixiang, Sun, Yingxian, Lu, Qinghua, Zhang, Ruiyan, Zhu, Jianhua, Xu, Yizhou, Fan, Zhongcai, Li, Tianchang, Wu, Chun, Jaramillo, Nicolas, Vallejo, Gregorio Sanchez, Luna Botia, Diana C, Lopez, Rodrigo Botero, De Salazar, Dora I Molina, Bonfanti, Alberto J Cadena, Aroca, Carlos Cotes, Higuera, Juan Diego, Blanquicett, Marco, Barrera Silva, Sandra I, Garcia Lozada, Henry J, Coronel Arroyo, Julian A, Accini Mendoza, Jose L, Fernandez Ruiz, Ricardo L, Quintero Ossa, Alvaro M., Manzur Jatin, Fernando G, Sotomayor Herazo, Aristides, Parada, Jeffrey Castellanos, Arambula, Rafael Suarez, Urina Triana, Miguel A, Trujillo, Angela M Fernandez, Strozzi, Maja, Car, Siniša, Miličić, Davor, Lovrić Benčić, Martina, Pintarić, Hrvoje, Prvulović, Đeiti, Šikić, Jozica, Peršić, Viktor, Mileta, Dean, Štambuk, Kresimir, Babić, Zdravko, Tomulic, Vjekoslav, Lukenda, Josip, Mejic-Krstulovic, Stanka, Starcevic, Boris, Spinar, Jindrich, Horak, David, Velicka, Zdenek, Alan, David, Machova, Vilma, Linhart, Ales, Novotny, Vojtech, Kaucak, Vladimir, Rokyta, Richard, Naplava, Robert, Coufal, Zdenek, Adamkova, Vera, Podpera, Ivo, Zizka, Jiri, Motovska, Zuzana, Marusincova, Ivana, Ostadal, Petr, Heinc, Petr, Kuchar, Jiri, Povolny, Petr, Matuska, Jiri, Poulsen, Steen H, Raungaard, Bent, Clemmensen, Peter, Bang, Lia E, May, Ole, Bøttcher, Morten, Hove, Jens D, Frost, Lars, Gislason, Gunnar, Larsen, John, Johansen, Peter Betton, Hald, Flemming, Johansen, Peter, Jeppesen, Jørgen, Nielsen, Tonny, Kristensen, Kjeld S, Walichiewicz, Piotr Maria, Lomholdt, Jens D, Klausen, Ib C, Nielsen, Peter Kaiser, Davidsen, Flemming, Videbaek, Lars, Viigimaa, Margus, Soots, Mai, Vahula, Veiko, Hedman, Anu, Soopõld, Üllar, Märtsin, Kaja, Jurgenson, Tiina, Kristjan, Arved, Nieminen, Markku S, Vikman, Saila, Huikuri, Heikki, Airaksinen, Juhani, Coste, Pierre, Ferrari, Emile, Danchin, Nicolas, Morel, Olivier, Montalescot, Gilles, Machecourt, Jacques, Barone-Rochette, Gilles, Mansourati, Jacques, Cottin, Yves, Steg, Ph. Gabriel, Leclercq, Florence, Belhassane, Abdelkader, Delarche, Nicolas, Boccara, Franck, Paganelli, Franck, Clerc, Jérôme, Schiele, Francois, Aboyans, Victor, Probst, Vincent, Berland, Jacques, Lefèvre, Thierry, Chumburidze, Vakhtang, Khintibidze, Irakli, Shaburishvili, Tamaz, Pagava, Zurab, Ghlonti, Ramaz, Lominadze, Zaza, Khabeishvili, George, Hemetsberger, Rayyan, Edward, Kemala, Rauch-Kröhnert, Ursula, Stratmann, Matthias, Appel, Karl-Friedrich, Schmidt, Ekkehard, Omran, Heyder, Stellbrink, Christoph, Dorsel, Thomas, Lianopoulos, Emmanouil, Vöhringer, Hans Friedrich, Marx, Roger, Zirlik, Andreas, Schellenberg, Detlev, Heitzer, Thomas, Laufs, Ulrich, Werner, Christian, Marx, Nikolaus, Gielen, Stephan, Nuding, Sebastian, Winkelmann, Bernhard, Behrens, Steffen, Sydow, Karsten, Karakas, Mahir, Simonis, Gregor, Muenzel, Thomas, Werner, Nikos, Leggewie, Stefan, Böcker, Dirk, Braun- Dullaeus, Rüdiger, Toursarkissian, Nicole, Jeserich, Michael, Weißbrodt, Matthias, Schaeufele, Tim, Weil, Joachim, Völler, Heinz, Waltenberger, Johannes, Natour, Mohammed, Schmitt, Susanne, Müller-Wieland, Dirk, Steiner, Stephan, Heidenreich, Lothar, Offers, Elmar, Gremmler, Uwe, Killat, Holger, Rieker, Werner, Patsilinakos, Sotiris, Kartalis, Athanasios, Manolis, Athanassios, Sionis, Dimitrios, Chachalis, Geargios, Liberopoulos, Evangelos, Skoumas, Ioannis, Athyros, Vasilios, Vardas, Panagiotis, Parthenakis, Frangkiskos, Hahalis, Georgios, Lekakis, John, Hatzitolios, Apostolos, Fausto Ovando, Sergio R, Montenegro Valdovinos, Pablo Carlos, Arango Benecke, Juan L, Rodriguez De Leon, Edgar R, Yan, Bryan PY, Siu, David CW, Turi, Tibor, Merkely, Bela, Gabor Kiss, Robert, Ungi, Imre, Lupkovics, Geza, Nagy, Lajos, Katona, András, Édes, István, Müller, Gábor, Horvath, Iván, Kapin, Tibor, Szigeti, Zsolt, Faluközy, József, Kumbla, Mukund, Sandhu, Manjinder, Annam, Sharath, Reddy Proddutur, Naveen, Regella, Reddy, Premchand, Rajendra K, Mahajan, Ajaykumar, Pawar, Sudhir, Abhyanakar, Atul D, Kerkar, Prafulla, Govinda, Ravishankar A, Oomman, Abraham, Sinha, Dhurjati, Patil, Sachin N, Kahali, Dhiman, Sawhney, Jitendra, Joshi, Abhijeet B, Chaudhary, Sanjeev, Harkut, Pankaj, Guha, Santanu, Porwal, Sanjay, Jujjuru, Srimannarayana, Pothineni, Ramesh B, Monteiro, Minguel R, Khan, Aziz, Iyengar, Shamanna S, Grewal, Jasprakash Singh, Chopda, Manoj, Fulwani, Mahesh C, Patange, Dr. Aparna, Sachin, Patil, Chopra, Vijay K, Goyal, Naresh K, Shinde, Rituparna, Manakshe, Gajendra V, Patki, Nitin, Sethi, Sumeet, Munusamy, Vengatesh, Sunil Thanvi, Sunil Karnaand, Adhyapak, Srilakshmi, Patil, Chandrakant, Pandurangi, Ulhas, Mathur, Rishabh, Gupta, Jugal, Kalashetti, Suhas, Bhagwat, Ajit, Raghuraman, Bagirath, Kumar Yerra, Shiv, Bhansali, Prasant, Borse, Rohidas, Rahul, Patil, Das, Srihari, Kumar, Vinay, Abdullakutty, Jabir, Saathe, Shireesh, Palimkar, Priya, Abdullkutty, Jabir, Sathe, Shireesh, Atar, Shaul, Shechter, Michael, Mosseri, Morris, Arbel, Yaron, Ehud, Chorin, Ofer, Havakuk, Lotan, Chaim, Rosenschein, Uri, Katz, Amos, Henkin, Yaakov, Francis, Adi, Klutstein, Marc, Nikolsky, Eugenia, Zukermann, Robert, Turgeman, Yoav, Halabi, Majdi, Marmor, Alon, Kornowski, Ran, Jonas, Michael, Amir, Offer, Hasin, Yonathan, Rozenman, Yoseph, Fuchs, Shmuel, Zvi, Vered, Hussein, Osamah, Gavish, Dov, Vered, Zvi, Caraco, Yoseph, Elias, Mazen, Tov, Naveh, Wolfovitz, Efrat, Lishner, Michael, Elias, Nizar, Piovaccari, Giancarlo, Pellegrin, Annamaria De, Garbelotto, Raffaella, Guardigli, Gabriele, Marco, Valgimigli, Licciardello, Giovanni, Auguadro, Carla, Scalise, Filippo, Cuccia, Claudio, Salvioni, Alessandro, Musumeci, Giuseppe, Senni, Michelle, Calabrò, Paolo, Novo, Salvatore, Faggiano, Pompilio, Metra, Marco, De Cesare, Nicoletta B, Berti, Sergio, Puccioni, Enrico, Galvani, Marcello, Tespili, Maurizio, Piatti, Piermarco, Palvarini, Michela, Luca, Giuseppe De, Violini, Roberto, Leo, Alessandro De, Olivari, Zoran, Filardi, Pasquale Perrone, Ferratini, Maurizio, Racca, Vittorio, Dai, Kazuoki, Shimatani, Yuji, Kamiya, Haruo, Ando, Kenji, Takeda, Yoshihiro, Morino, Yoshihiro, Hata, Yoshiki, Kimura, Kazuo, Kishi, Koichi, Michishita, Ichiro, Uehara, Hiroki, Higashikata, Toshinori, Hirayama, Atsushi, Hirooka, Keiji, Doi, Yasuji, Sakagami, Satoru, Taguchi, Shuichi, Koike, Akihiro, Fujinaga, Hiroyuki, Koba, Shinji, Kozuma, Ken, Kawasaki, Tomohiro, Ono, Yujiro, Shimizu, Masatoshi, Katsuda, Yousuke, Wada, Atsuyuki, Shinke, Toshiro, Kimura, Takeshi, Ako, Junya, Fujii, Kenshi, Takahashi, Toshiyuki, Nakao, Koichi, Furukawa, Yutaka, Sugino, Hiroshi, Tamura, Ritsu, Mano, Toshiaki, Uematsu, Masaaki, Utsu, Noriaki, Ito, Kashima, Haraguchi, Takuya, Sato, Katsuhiko, Ueda, Yasunori, Nishibe, Akira, Fujimoto, Kazuteru, Masutani, Motomaru, Nishibe, Akira, Fujimoto, Kazuteru, Yoon, Jung Han, Kim, Sang-Hyun, Kim, Hack-Lyoung, Sik Park, Hun, Chae, In-Ho, Kim, Moo Hyun, Jeong, Myung Ho, Rha, Seungwoon, Kim, Chongjin, Kim, Hyo-Soo, Kim, Hae Young, Hong, Taekjong, Tahk, Seung-Jea, Kim, Youngkwon, Busmane, Arija, Pontaga, Natalija, Strelnieks, Aldis, Mintale, Iveta, Sime, Iveta, Petrulioniene, Zaneta, Kavaliauskiene, Roma, Jurgaitiene, Ruta, Sakalyte, Gintare, Slapikas, Rimvydas, Norkiene, Sigute, Misonis, Nerijus, Kibarskis, Aleksandras, Kubilius, Raimondas, Bojovski, Stojko, Kedev, Sasko, Lozance, Nensi, Kjovkaroski, Aleksandar, Doncovska, Snezana, Ong, Tiong Kiam, Kasim, Sazzli, Maskon, Oteh, Kandasamy, Balachandran, Yusoff, Khalid, Liew, Houng B, Wan Mohamed, Wan Mohd Izani, Castillo, Armando García, Ramos López, Gabriel Arturo, Calvillo, Jorge Carrillo, Campos, Pedro Fajardo, Núñez Fragoso, Juan Carlos, Bayram Llamas, Edmundo Alfredo, Alcocer Gamba, Marco Antonio, Madrigal, Jaime Carranza, González Salas, Luis Gerardo, Rosas, Enrique López, González Díaz, Belinda, Vázquez, Eduardo Salcido, Nacoud Ackar, Alfredo, Llamas Esperón, Guillermo Antonio, Martínez Sánchez, Carlos Rodolfo, De Leon, María Guerrero, Suarez Otero, Rodrigo, Salmón, Guillermo Fanghänel, Pérez Ríos, Jesús 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Mladen, Knutson, Thomas, Friedman, Dennis, Chaleff, Fred, Loussararian, Arthur, Rozeman, Phillip, Kimmelstiel, Carey, Kuvin, Jeffrey, Silver, Kevin, Foster, Malcolm, Tonnessen, Glen, Espinoza, Andrey, Amlani, Mohamadali, Wali, Andreas, Malozzi, Christopher, Jong, Geert T, Massey, Clara, Wattanakit, Keattiyoat, O’Donnell, Philip J., Singal, Dinesh, Jaffrani, Naseem, Banuru, Sridhar, Fisher, Daniel, Xenakis, Mark, Perlmutter, Neal, Bhagwat, Ravi, Strader, James, Blonder, Ronald, Akyea-Djamson, Ayim, Labroo, Ajay, Lee, Kwan, Marais, H. John, Claxton, Edmund, Weiss, Robert, Kathryn, Rohr, Berk, Martin, Rossi, Peter, Joshi, Parag, Khera, Amit, Khaira, Ajit S, Kumkumian, Greg, Lupovitch, Steven, Purow, Joshua, Welka, Stephen, Hoffman, David, Fischer, Stuart, Soroka, Eugene, Eagerton, Donald, Pancholy, Samir, Ray, Michael, Erenrich, Norman, Farrar, Michael, Pollock, Stewart, French, William J, Diamantis, Steve, Guy, Douglas, Gimple, Lawrence, Neustel, Mark, Schwartz, Steven, Pereira, Edward, Albert, Seals, Spriggs, Douglas, Strain, Janet, Mittal, Suneet, Vo, Anthony, Chane, Majed, Hall, Jason, Vijay, Nampalli, Lotun, Kapildeo, Lester, F. Martin, Nahhas, Ahed, Pope, Theodore, Nager, Paul, Vohra, Rakesh, Sharma, Mukesh, Bashir, Riyaz, Ahmed, Hinan, Berlowitz, Michael, Fishberg, Robert, Barrucco, Robert, Yang, Eric, Radin, Michael, Sporn, Daniel, Stapleton, Dwight, Eisenberg, Steven, Landzberg, Joel, Mcgough, Martin, Turk, Samir, Schwartz, Michael, Sundram, P. Sandy, Jain, Diwakar, Zainea, Mark, Bayron, Carlos, Karlsberg, Ronald, Dohad, Suhail, Lui, Henry, Keen, William, Westerhausen, Donald, Khurana, Sandeep, Agarwal, Himanshu, Birchem, Jessica, Penny, William, Chang, Mark, Murphy, Sherrill, Henry, John, Schifferdecker, Branislav, Gilbert, John M, Chalavarya, Gopal, Eaton, Charles, Schmedtje, John F, Christenson, Stuart, Dotani, Imran, Denham, Douglas, Macdonell, Alexander, Gibson, Paul, Rahman, Aref, Al Joundi, Tammam, Assi, Nizar, Conrad, Gary, Kotha, Purushotham, Love, Michael, Giesler, Gregory, Rubenstein, Howard, Gamil, Dawood, Akright, Laura, Krawczyk, Justine, Cobler, Joanne, Wells, Terry, Welker, James, Foster, Robert, Gilmore, Richard, Anderson, Jay, Jacoby, Douglas, Harris, Bill, Gardner, Geraldine, Dandillaya, Ramprasad, Vora, Kishor, Kostis, John, Hunter, John, Laxson, David, Ball, Eric, Anderson, Jay, Wells, Terry, Vora, Kishor, Ball, Eric, Welker, James, Lopes, Renato D., Egydio, Flavia, Kawakami, Anelise, Oliveira, Janaina, Goodman, Shaun G., Wozniak, Julianna, Matthews, Alexander, Ratky, Caroline, Valiris, Janine, Berdan, Lisa, Hepditch, Anita, Quintero, Kirby, Roe, Matthew T., Rorick, Tyrus, Westbrook, Melissa, Danchin, Nicolas, Bezault, Madeleine, Drouet, Elodie, Simon, Tabassome, White, Harvey D., Alsweiler, Caroline, Sinnaeve, Peter, Luyten, Anne, Aylward, Philip E, Butters, Julie, Griffith, Liddy, Shaw, Michelle, Hagström, Emil, Grunberg, Lena, Szarek, Michael, Islam, Shahidul, Brégeault, Marie-France, Bougon, Nathalie, Faustino, Douglas, Fontecave, Sylvie, Murphy, Judith, Tamby, Jean- Francois, Verrier, Melanie, Agnetti, Veronique, Andersen, Dorthe, Badreddine, Emmy, Bekkouche, Mhamed, Bouancheau, Cecile, Brigui, Imane, Brocklehurst, Maddy, Cianciarulo, Joseph, Devaul, Dawn, Domokos, Szilvia, Gache, Cecile, Gobillot, Caroline, Guillou, Severine, Healy, Jan, Heath, Megan, Jaiwal, Gayatri, Javierre, Carine, Labeirie, Julien, Monier, Myriam, Morales, Ulises, Mrabti, Asmaa, Mthombeni, Bicky, Okan, Betim, Smith, Lucile, Sheller, Jennifer, Sopena, Sebastien, Pellan, Valerie, Benbernou, Fadela, Bengrait, Nafissa, Lamoureux, Maud, Kralova, Katarina, Scemama, Michel, Bejuit, Raphael, Coulange, Anthony, Berthou, Christelle, Repincay, Jérôme, Lorenzato, Christelle, Etienne, Alexis, Gouet, Valerie, Lecorps, Guillaume, Loizeau, Virginie, Normand, Mickael, Ourliac, Anne, Rondel, Christelle, Adamo, Antony, Beltran, Pascale, Barraud, Pauline, Dubois-Gache, Helene, Halle, Benjamin, Metwally, Lamia, Mourgues, Maxime, Sotty, Marc, Vincendet, Marion, Cotruta, Raluca, Chengyue, Zhu, Fournie-Lloret, Dominique, Morrello, Christine, Perthuis, Aurelie, Picault, Patrick, Zobouyan, Isabelle, Colhoun, Helen M., Dempsey, Michael A., and McClanahan, Mark A.

Published
2022
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41. Substitució i pervivència de la toponímia prejaumina en el paisatge valencià després de l’expulsió dels moriscos: el cas del terme d’Onda a través d’establiments de colons en 1617

Author

Xiva i Molina, Ismael and Xiva i Molina, Ismael

Abstract

Aquest article presenta un estudi de cas dels topònims presents en els vint establiments conservats que serviren per a repoblar en 1617 la Moreria de la vila d’Onda i els llocs d’Artesa i Tales (la Plana Baixa, País Valencià) després de l’expulsió dels moriscos en 1609. A través dela seua anàlisi, es pretén determinar si la substitució del corpus toponímic prejaumí d’aquesta comunitat en els indrets en què vivia en contacte amb comunitats cristianes es dugué a terme a partir d’aquest moment o si ja s’havia iniciat des de la conquesta. Els resultats revelen que els cristians implantaren els seus noms de lloc des del segle XIII, però que va haver altres que foren assumits per aquells i han sobreviscut fins a hui dia., This article presents a case study of the toponyms included in the twenty emphyteutic establishments conserved that served to repopulate in 1617 the Moorish neighbourhood of Onda and the villages of Artesa and Tales (la Plana Baixa, Valencian Country) after the Expulsion of the Moriscos in 1609. Through this analysis, the study aims to determine whether the replacement of the Pre-Jamesi antoponymic corpus of this community, in areas where they coexisted with Christian communities, began at this time or had started earlier, during the conquest. The results reveal that Christians began imposing their names in the 13th century, but some names were assimilated and have survived to this day., Este artículo presenta un estudio de caso de los topónimos presentes en los veinte establecimientos conservados que sirvieron para repoblar en 1617 la Morería de la villa de Onda y los lugares de Artesa y Tales (Plana Baja, País Valenciano) tras la expulsión de los moriscos en 1609. A través de su análisis, se pretende determinar si la sustitución del corpus toponímico prejaimino de esta comunidad en los sitios en los que vivía en contacto con comunidades cristianas se llevó a término a partir de este momento o si ya se había iniciado desde la conquista. Los resultados revelan que los cristianos implantaron sus nombres de lugar desde el siglo XIII, pero que hubo otros que fueron asumidos por aquellos y han sobrevivido hasta hoy en día.

Published
2024

44. AN ASSESSMENT OF EMERGING NETWORKS IN THE FRUIT SECTOR: THE CASE OF INCA BERRY IN ECUADOR

Author

C., Moreno-Miranda, A., Pilamala, I., Molina, L., Cerda-Mejia, R., Moreno-Miranda, and Rama, D.

Subjects
Sustainable development, Actors, Distribution channels, Food, Business logistics, Retail trade, Marketing, Setting (Literature), Environmental auditing, Production management, Direct market channel, Retail/reseller channel, Agricultural industry, Food/cooking/nutrition, Health
Abstract

The diversification of agri-food products through emerging chains has a fundamental social and economic role in Ecuador. A substantial amount of research focused only on examining critical factors in terms of agronomic and environmental performance. However, there is a shift in the agri-food chain perspective and study towards more sustainable models of production, logistics trade, and consumption. Aspects such as the socio-economic sustainability, level of collaboration between actors, an adequate chain configuration, and the employment of smart governance mechanisms show the weaknesses where stakeholders can propose enhancements. In this respect, socio-economic and productive factors are consequential and still affecting the progress of these chains. Also, the current growth of market opportunities at the local and international level is a driver to support them by setting sustainable strategies. This study aimed to analyze socio-economic and production aspects to understand the dynamic across the emerging Inca berry (Physalis peruviana) chain located in Ecuador and bring forward potential strategies. Thus, chain vertical and horizontal dimensioning was introduced to contribute with relevant insights. The framework applied accounts with a revision of primary and support activities, and flows of high and low relevance. The investigation clustered pre-production, production, and post-production tiers. Also, it executed the food chain mapping, the identification of chain actors, and application of surveys at the supply chain levels to identify strengths and weaknesses based on specific socio-economic and productive variables. Results stated several viable long-term strategies. Examples of those strategies are the diversification of marketing channels, the intervention of academic institutions to improve efficiency, productivity, and the associations' empowerment. All of them aimed at circular economic models. The main research contribution is the application of the chain configuration to assess the chain performance comprehensively. Based on the results, our recommendation is incorporating new indicators to analyze the environmental and institutional components profoundly. Key words: Inca berry, dimensioning, performance, associative structures, rural extension, INTRODUCTION In the last decade, the growth of exports of crops has been significant in Latin American countries [1]. These exports are mainly fresh products such as flowers, fruits, vegetables, [...]

Published
2020
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48. Ureaplasma urealyticum and Mycoplasma hominis urogenital infections associate with semen inflammation and decreased sperm quality

Author

Daniela A Paira, Carolina Olivera, Andrea D Tissera, Rosa I Molina, José J Olmedo, Virginia E Rivero, Héctor A Saka, and Ruben D Motrich

Subjects
Immunology, Immunology and Allergy, Cell Biology
Abstract

Ureaplasma urealyticum and Mycoplasma hominis are among the most prevalent sexually transmitted infections proposed to induce urogenital inflammation and impair sperm quality. However, the topic remains controversial since contradictory findings have been reported. Herein, we performed a comprehensive analysis of U. urealyticum and M. hominis urogenital infections and their association with urogenital inflammation (i.e., leukocyte subsets and inflammatory cytokines in semen,) and sperm quality parameters in a cohort of men with couple’s primary infertility undergoing initial infertility evaluation or with lower urinary tract symptoms and no infertility-related complaints. Overall, U. urealyticum and M. hominis infection was detected in 17.0% and 23.6% of patients, respectively, whereas the coinfection was detected in 3.8% of patients only. Remarkably, similar infection frequencies were found in the different patient subpopulations analyzed. Moreover, infections were associated with elevated semen levels of TNF, IL-1β, and IL-6 and/or increased counts of total leukocytes and their subsets, including CD4 and CD8 T lymphocytes and neutrophils. In addition, M. hominis infection and the coinfection with U. urealyticum were associated with impairments in sperm quality variables. Our results indicate that U. urealyticum and M. hominis male urogenital infections induce urogenital inflammation and decrease sperm quality, thus impairing male fertility potential. Screening for U. urealyticum and M. hominis infections and performing a comprehensive analysis of different leukocyte subsets and inflammatory cytokines in semen may be clinically helpful in the diagnosis and follow-up of male urogenital infection.

Published
2023
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49. Iberian experience with PASCAL transcatheter edge-to-edge repair for mitral valve regurgitation

Author

Chi-Hion Pedro Li, Rodrigo Estévez-Loureiro, Xavier Freixa, Rui Teles, Ana I. Molina-Ramos, Manuel Pan, Luis Nombela-Franco, Bruno Melica, Ignacio J. Amat-Santos, Ignacio Cruz-González, Lluís Asmarats, Robert Alarcón, Laura Sanchis, Estefanía Fernández-Peregrina, José Antonio Baz, Xavier Millán, Irene Menduiña, and Dabit Arzamendi

Subjects
Male, Heart Valve Prosthesis Implantation, Cardiac Catheterization, Treatment Outcome, Humans, Mitral Valve Insufficiency, Mitral Valve, Female, General Medicine, Aged
Abstract

The PASCAL system is a novel device for transcatheter mitral valve repair based on the edge-to-edge concept. The unique features of this device might have a relevant impact on the repair outcomes. There are few data on clinical outcomes in real-life registries. The aim of this study was to report the early Iberian experience (Spain and Portugal) of the PASCAL system.Procedural and 30-day outcomes were investigated in consecutive patients with symptomatic severe mitral regurgitation (MR) treated with the PASCAL system at 10 centers. Primary efficacy endpoints were technical success and degree of residual MR at discharge. The primary safety endpoint was the rate of major adverse events (MAE) at 30 days.We included 68 patients (age, 75 [68-81] years; 38% women; EuroSCORE II 4.5%). MR etiology was degenerative in 25%, functional in 65%, and mixed in 10%. A total of 71% of patients were in New York Heart Association (NYHA) functional class≥III. Technical success was achieved in 96% and independent capture was used in 73% of procedures. In the treated population, MR at discharge was≤2+ in 100%, with no in-hospital deaths. At 30 days, the MAE rate was 5.9%, the all-cause mortality rate was 1.6%, 98% were in NYHA functional class≤II, and 95% had MR≤2+ (P.001).Transcatheter mitral valve repair with the PASCAL system was safe and effective, with high procedural success and low rates of MAE. At 30 days, MR was significantly reduced, with a significant improvement in functional status.

Published
2023
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50. Experiencia ibérica con PASCAL para la reparación percutánea borde a borde en insuficiencia mitral

Author

Chi-Hion Pedro Li, Rodrigo Estévez-Loureiro, Xavier Freixa, Rui Teles, Ana I. Molina-Ramos, Manuel Pan, Luis Nombela-Franco, Bruno Melica, Ignacio J. Amat-Santos, Ignacio Cruz-González, Lluís Asmarats, Robert Alarcón, Laura Sanchis, Estefanía Fernández-Peregrina, José Antonio Baz, Xavier Millán, Irene Menduiña, and Dabit Arzamendi

Subjects
Cardiology and Cardiovascular Medicine
Published
2023
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