Search

Your search keyword '"I. Meij"' showing total 5 results
Start Over Author "I. Meij"
5 results on '"I. Meij"'

1. Genetic diseases and molecular genetics - 2

Author

Kenneth I. Glassberg, David G. Motto, Chong Zhang, Valeriy Nosikov, E.I. Christensen, Mikhail Shvetsov, Bin Zhu, Ana Paula Rodrigues Melo, Manuela Cuccurullo, Ryszard Grenda, Vladimir Tesar, Guido Gatti, Boris Utsch, Susanna Tomasoni, Nan Chen, A. Schirinzi, Nobuaki Takagi, Maria Roszkowska-Blaim, Semiramis Jamil Adad do Monte, Eric Wise, Federica Mezzabotta, Fabien Nevo, Wolf H. Fridman, Véronique Frémeaux-Bacchi, Angela D'Angelo, Joseph H. Lee, Christian Becker, Monica Ceol, Andrea Emmert, Elena Kamyshova, Dorothee Schönfeld, Dali Dalia, Adile Akdas, Peter Nürnberg, Fatiu A Arogundade, Franca Anglani, Frank Bienaimé, Carsten A. Wagner, Céline Becker, Zhaohui Wang, Maja Krzysztalowska, Kálmán Tory, João Bosco, Ali G. Gharavi, Piera Trionfini, Malgorzata Panczyk-Tomaszewska, Maria Bracale, Martijn J. Wilmer, Abubakr Sanusi, M Merta, Vera Krane, Bruno Ranchin, Marie-Agnes Dragon-Durey, Ellen Shapiro, Andrzej Ciechanowicz, Aleksey Shestakov, Karolina Skonieczna, Rémi Salomon, Pierre Ronco, Ahmet Nayir, Dominik N. Müller, Elena Ranieri, Ilenia Bernascone, Giuseppe Remuzzi, QiuJu Liu, Faddi Fakhouri, Irina Kutyrina, Patricia L. Weng, Corinne Antignac, Massimo Attanasio, Celin Schaeffer, Jitka Stekrova, Vinay Sakhuja, Jean-Luc Andre, Sidarth Kumar Sethi, Laura Zagato, Giorgio Casari, Pauling Chu, Frank Breunig, L Salawu, Olivier Gribouval, I. Meij, Leo A. H. Monnens, Dorella Del Prete, Mustafa Solak, Mieczyslaw Litwin, Loreto Gesualdo, Nazim Denizli, P. Cerullo, Lambertus P. van den Heuvel, Christoph Wanner, Shih-Hua Lin, W. van't Hoff, P. Deen, Muheez A. Durosinmi, Christian Noel, Frank Weidemann, G. Messina, Lorena Longaretti, Pinar Ata Eren, Veronika Elisakova, Emilia Tiralongo, Ling Qin, Stanislava Svobodova, Gian Marco Ghiggeri, Marta Drozdzynska, Anne-Laure Sellier-Leclerc, Sung-Sen Yang, Jarosław Peregud-Pogorzelski, José Adail Fonseca de Castro, Chiara Lanzani, Lino Merlino, Fabrizio Dal Piaz, Cristina Malaventura, Chantal Loirat, Wen Zhang, Monica Dagnino, Marco Simonini, Vivekanand Jha, Lina Artifoni, Lorena Citterio, Gudrun Nürnberg, Grażyna Adler, Friedhelm Hildebrandt, Elisa Benetti, Lorenzo A. Calò, Michael Zirbs, Terry W. Hensle, Eduardo Machuca, Arnaud Garnier, Solmaz Erdem, Andrzej Brodkiewicz, Caroline Blanc, Audrey Pawtowski, Miriam Galbusera, Muzzamil Hassan, M. Belingheri, Hong Ren, Anita Konka, Reiterová J, Jackeline Larissa Mendes de Sousa, Yasaswi Paruchuri, Luca Rampoldi, N.V. Knoers, Milada Kohoutová, L. Rampoldi, Simona Delli Carpini, Francesco Scolari, H. Mehmet Sokmen, Annalisa Vilasi, Maddalena Gigante, O. Devuyst, Antonio Malorni, Elena Levtchenko, Nirupama Chandel, Leo A. J. Kluijtmans, Giovambattista Capasso, Sam Werzberger, Zeynep Acar, Simone Sanna-Cherchi, José Tibúrcio do Monte Neto, L. Ghio, Weiming Wang, Sophie Saunier, Xavier Jeunemaitre, Robert D. Burk, FuDe Huang, Elena Brioni, Paolo Manunta, Luisa Murer, G.M. Ghiggeri, P. K. Aggarwal, Daniela Corna, Yi-Fen Lo, Ana Maria Martins, Edgar A. Otto, Adewale Akinsola, Anatália de Brito Ribeiro da Silva, Roberto Ravazzolo, Enrica Tosetto, Dorothee Schoenfeld, Yu-Juei Hsu, Claudia Izzi, Ariela Benigni, Alan Werzberger, Matthias T.F. Wolf, Gianluca Caridi, Giuseppe Bianchi, Vânia D'Almeida, Irina Davydenko, and E.N. Levtchenko

Subjects
Genetics, Transplantation, medicine.medical_specialty, Nephrology, business.industry, Molecular genetics, medicine, business, Human genetics
Published
2009
Full Text
View/download PDF

3. Magnesium stimulates renal phosphate reabsorption.

Author

Thumfart J, Jung S, Amasheh S, Krämer S, Peters H, Sommer K, Biber J, Murer H, Meij I, Querfeld U, Wagner CA, and Müller D

Subjects
Animal Feed, Animals, Fibroblast Growth Factors blood, Immunohistochemistry, Linoleic Acids blood, Male, Parathyroid Hormone blood, Parathyroidectomy, RNA, Messenger metabolism, Rats, Rats, Sprague-Dawley, Sodium-Phosphate Cotransporter Proteins, Type IIa genetics, Sodium-Phosphate Cotransporter Proteins, Type IIc genetics, gamma-Linolenic Acid blood, Kidney metabolism, Magnesium pharmacology, Phosphates metabolism, Sodium-Phosphate Cotransporter Proteins, Type IIa metabolism, Sodium-Phosphate Cotransporter Proteins, Type IIc metabolism
Abstract

In the kidney, approximately 80% of the filtered phosphate (Pi) is reabsorbed along the proximal tubule. Changes in renal Pi reabsorption are associated with modulation of the sodium-dependent Pi cotransporter type IIa (NaPi-IIa) and type IIc (NaPi-IIc) protein abundance in the brush-border membrane (BBM) of proximal tubule cells. NaPi-IIa is mainly regulated by dietary Pi intake and parathyroid hormone (PTH). The purpose of the present study was to elucidate the effect of alteration in dietary magnesium (Mg2+) intake on renal Pi handling. Urinary Pi excretion and renal expression of NaPi-IIa and NaPi-IIc were analyzed in rats fed a normal (0.2%) or high-Mg2+ (2.5%) diet. A high-Mg2+ diet resulted in decreased renal Pi excretion and increased protein expression of NaPi-IIa and NaPi-IIc. Serum FGF-23 (fibroblast growth factor 23) levels were unchanged under a high-Mg2+ diet. Serum PTH levels were slightly decreased under a high-Mg2+ diet. To examine whether the observed changes in renal Pi reabsorption are PTH dependent, expression of NaPi-IIa and NaPi-IIc was also analyzed in parathyroidectomized (PTX) rats fed a normal or high-Mg2+ diet. In PTX rats, Mg2+ had no significant effect on renal Pi excretion or NaPi-IIa protein expression. Mg2+ increased NaPi-IIc protein expression in PTX rats. This experiment shows for the first time on the molecular level how Mg2+ stimulates renal Pi reabsorption. Under a high-Mg2+ diet, NaPi-IIa expression is dependent on PTH levels, whereas NaPi-IIc expression seems to be independent of PTH levels.

Published
2008
Full Text
View/download PDF

4. The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.

Author

Willnow T, Antignac C, Brändli A, Christensen E, Cox R, Davidson D, Davies J, Devuyst O, Eichele G, Hastie N, Verroust P, Schedl A, and Meij I

Abstract

Rapid progress in genome research creates a wealth of information on the functional annotation of mammalian genome sequences. However, as we accumulate large amounts of scientific information we are facing problems of how to integrate and relate the data produced by various genomic approaches. Here, we propose the novel concept of an organ atlas where diverse data from expression maps to histological findings to mutant phenotypes can be queried, compared and visualized in the context of a three-dimensional reconstruction of the organ. We will seek proof of concept for the organ atlas by elucidating genetic pathways involved in development and pathophysiology of the kidney. Such a kidney atlas may provide a paradigm for a new systems-biology approach in functional genome research aimed at understanding the genetic bases of organ development, physiology and disease.

Published
2005
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results