8 results on '"I. Kilgallen"'
Search Results
2. Circulating interleukin 6 and interleukin 10 in community acquired pneumonia
- Author
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N Murphy, P. Glynn, I Kilgallen, Shane J. O'Neill, and R. Coakley
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Adult ,Pulmonary and Respiratory Medicine ,medicine.medical_treatment ,Enzyme-Linked Immunosorbent Assay ,Sepsis ,Age Distribution ,Community-acquired pneumonia ,Severity of illness ,medicine ,Humans ,Interleukin 6 ,APACHE ,Aged ,APACHE II ,biology ,Interleukin-6 ,business.industry ,Original Articles ,Pneumonia ,Middle Aged ,medicine.disease ,Systemic Inflammatory Response Syndrome ,Interleukin-10 ,Community-Acquired Infections ,Systemic inflammatory response syndrome ,Interleukin 10 ,Cytokine ,Immunology ,biology.protein ,business - Abstract
Background—Inflammatory cytokine concentrations correlate with severity of sepsis. We hypothesised that patients with community acquired pneumonia (CAP) associated with systemic inflammatory response syndrome (SIRS) would have greater interleukin 6 (IL-6) production due to activation of the inflammatory cytokine cascade, matched by a significant anti-inflammatory cytokine response. Interleukin 10 (IL-10) was evaluated as a potential surrogate marker of severity of sepsis in CAP and age related impairment of the cytokine response was studied in elderly patients with CAP. Methods—Circulating immunoreactive IL-6 and IL-10 levels were measured in 38 patients with CAP subdivided into a group fulfilling the criteria for SIRS (n = 28) and a non-SIRS group (n = 10) in a variety of age groups and correlated with APACHE II scores. Results—80% had circulating IL-6 levels (median 46.7 pg/ml, range 4.6‐27 000) and 60% had circulating IL-10 levels (median 15.5 pg/ml, range 2.5‐765). Concentrations of both were significantly increased in patients with SIRS compared with nonSIRS patients. Those with activation of the inflammatory cytokine cascade (IL-6 positive) produced more IL-10 than IL-6 negative patients. Older patients had a similar cytokine response. Both cytokines correlated positively with APACHE II scores. Conclusions—This is the first demonstration of circulating IL-10 in CAP. A greater counter-inflammatory response in patients with SIRS and in IL-6 positive patients suggests a potential immunomodulatory role for IL-10 in controlling the inflammatory cytokine response in CAP. IL-10 concentrations correlate with severity of illness in CAP and may be of prognostic importance. There is no age related impairment in the cytokine response. (Thorax 1999;54:51‐55)
- Published
- 1999
- Full Text
- View/download PDF
3. Parental perception of food allergy or intolerance in children under 4 years of age
- Author
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Michael J. Gibney and I. Kilgallen
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Pediatrics ,medicine.medical_specialty ,Nutrition and Dietetics ,business.industry ,Food allergy or intolerance ,digestive, oral, and skin physiology ,Medicine (miscellaneous) ,medicine.disease ,Rash ,Food allergy ,medicine ,Parental perception ,medicine.symptom ,business ,Infant feeding - Abstract
The perceived prevalence of food allergy among parents of pre-school children in Ireland is unknown. An interview-assisted questionnaire was used to interview the parents of 600 children, aged 0–4 years, about food allergy. Twelve and a half per cent of the children were perceived by their parents to be food allergic. However, no instance of food allergy in children aged under 6 months was reported. Hyperactivity was the most common symptom noted, with sweets, sugary drinks and food colours being the most frequently implicated foods. Rash, the second most common symptom cited was largely associated with dairy products and eggs. Neither parental age, education, socio-economic groups or infant feeding practices affected perception of food allergy. Food allergy was diagnosed primarily by the parents themselves using simple food avoidance.
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- 1996
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- View/download PDF
4. Irish Thoracic Society
- Author
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T. Feeney, O. O’Muire, J. J. Gilmartin, P. Manning, H. Sinclair, L. Clancy, F. O’Connell, D. R. Springall, J. M. Polak, V. E. Thomas, R. W. Fuller, N. B. Pride, R. A. Lyons, C. Leonard, J. Faul, V. J. Tormey, L. W. Poulter, C. M. Burke, S. Pathmakanthan, M. C. Barry, J. H. Wang, C. J. Kelly, P. E. Burke, S. J. Sheehan, H. P. Redmond, D. Bouchier-Hayes, H. Abdih, R. W. G. Watson, P. Burke, J. J. Egan, L. Barber, J. Lomax, A. Fox, J. Craske, N. Yonan, A. N. Rahman, A. K. Deiraniya, K. B. Carroll, A. Turner, A. A. Woodcock, K. McNeill, B. Bookless, K. Gould, P. Corris, T. Higgenbottam, A. Webb, A. Woodcock, K. McManus, D. Miller, M. Allen, D. Ilstrup, C. Deschamps, V. Trastek, P. Pairolero, T. P. Cotter, C. Vaughan, W. P. Kealy, P. F. Duggan, A. Curtain, C. P. Bredin, A. Waite, C. P. Maguire, J. Ryan, D. O’Neill, D. Coakley, J. B. Walsh, I. Kilgallen, S. O’Neill, M. Ryan, C. M. O’Connor, T. McDonnell, R. C. Lowry, J. B. Buick, T. R. A. Magee, D. O’Riordan, J. Hayes, C. O’Connor, M. X. FitzGerald, C. Cosgrave, C. Costello, P. C. Deegan, W. T. McNicholas, A. M. Nugent, J. Lyons, I. Gleadhill, J. MacMahon, E. C. Stevenson, L. G. Heaney, M. D. Shields, I. S. Cadden, R. Taylor, M. Ennis, S. A. Kharitonov, J. O’Connor, W. A. Owens, H. O’Kane, J. Cleland, D. J. Gladstone, M. Sarsam, A. N. J. Graham, V. Anikin, J. A. McGuigan, R. C. Curry, G. Varghese, P. Keelan, R. Rutherford, D. O’Keeffe, P. McCarthy, H. Moore, E. Balbernie, R. Coakley, M. Keane, R. Costello, P. Byrne, D. McKeogh, P. McLoughlin, G. Finlay, D. Concannon, D. McKeown, P. Kelly, W. A. Tanner, D. J. Bouchier-Hayes, M. Arumugasamy, K. Yacoub, G. O’Leary, K. Stokes, J. Geraghty, H. Osborne, R. O’Dwyer, R. Gilliland, S. M. Saleem, T. Aherne, C. K. Power, C. H. Burke, A. Byrne, J. F. A. Murphy, R. Sharkey, E. Mulloy, K. Sharkey, M. Long, M. A. Birchall, A. Moorat, J. Henderson, L. Jacques, P. Cahill, C. Condron, D. Royston, J. Murphy, and S. O. Neill
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General Medicine - Published
- 1995
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5. National scientific medical meeting 1995 abstracts
- Author
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S. Norris, C. Collins, J. Hegarty, C. O’Farrelly, J. Carton, L. Madrigal, D. P. O’Donoghue, H. Holloway, J. F. Fielding, W. Mullins, S. W. Hone, M. Donnelly, F. Powell, A. W. Blayney, E. A. Cahill, S. F. Daly, M. J. Turner, P. A. Sullivan, M. McLoughlin, M. M. Skelly, H. E. Mulcahy, T. Connell, C. Duggan, M. J. Duffy, A. Troy, K. Sheahan, A. Whelan, C. M. Herra, C. T. Keane, H. Johnson, B. Lee, E. Doherty, T. McDonnell, D. Mulherin, O. FitzGerald, B. Bresnihan, H. M. Hassett, A. Boyce, V. Greig, C. O’Herlihy, P. P. A. Smyth, E. F. Roche, I. McCormack, E. Tempany, M. J. Cullen, D. F. Smith, Y. McBrinn, B. Murray, R. Freaney, D. Keating, M. J. McKenna, J. A. O’Hare, H. Alam, Q. Raza, M. Geoghegan, S. Killalea, M. Hall, J. Feely, L. Kyne, B. O’Hara, M. Cullen, I. M. Rea, J. P. Donnelly, R. W. Stout, P. Lacey, M. J. Donnelly, J. McGrath, T. P. Hennessy, C. V. I. Timon, D. Hyde, H. X. Xia, M. Buckley, C. O’Morain, S. Keating, H. Xia, J. P. McGrath, R. C. Stuart, P. Lawlor, P. J. Byrne, T. N. Walsh, T. P. J. Hennessy, M. Duffy, M. Tubridy, J. Redmond, K. Monahan, R. P. Murphy, D. R. Headon, T. O’Gorman, F. M. O’Reilly, C. Darby, G. M. Murphy, A. Murphy, M. Codd, P. Dervan, D. Lawlor, S. O. Loughlin, N. Flanagan, R. Watson, L. Barnes, C. Kilgallen, E. Sweeney, A. Mynes, D. Mooney, I. Donoghue, O. Browne, J. A. Kirrane, D. McKenna, M. Young, E. O’Toole, S. O’Briain, U. Srinivasan, C. Feighery, N. Leonard, E. Jones, M. A. Moloney, D. G. Weir, M. Lawler, A. O’Neill, H. Gowing, D. Pamphilon, S. R. McCann, G. O’Toole, A. Orren, C. M. Seifer, D. C. Crowley, G. J. Sheehan, T. Deignan, J. Kelly, V. J. Tormey, J. Faul, C. Leonard, C. M. Burke, L. W. Poulter, S. Lynch, G. McEntee, O. Traynor, E. Barry, P. Costello, A. Keavney, R. Willoughby, C. O’Donnell, M. Cahill, A. Earley, P. Eustace, R. Osborne, C. Saidlear, B. Holmes, A. Early, A. P. Moran, A. Neisser, R. J. Polt, H. Bernheimer, M. Kainz, B. Schwerer, L. Gallagher, R. Firth, N. Kennedy, E. McGilloway, N. Tubridy, K. Shields, W. K. Cullen, M. J. Rowan, A. R. Moore, M. Rowan, D. Coakley, B. Lawlor, G. Swanwick, R. Al-Naeemi, R. Murphy, N. M. Codd, M. Goggins, N. P. Kennedy, B. L. Mallon, H. Mulcahy, M. Skelly, D. O. Donoghue, D. McCarthy, A. Saunders, D. J. Veale, J. J. F. Belch, D. Breathnach, E. Murphy, G. Kernohan, K. Gibson, A. G. Wilson, G. W. Duff, N. de Vries, L. B. A. van de Putte, J. Donoghue, F. O’Kelly, Z. Johnson, T. Maher, A. Moran, C. Keane, D. O’Neill, N. Horgan, J. M. Barragry, D. M. Campbell, M. Behan, P. R. O’Connell, V. S. Donnelly, D. Crowley, M. Geary, P. Boylan, M. Fanagan, K. Hickey, T. Teoh, M. Doyle, R. Harrison, D. Lyons, Y. Shenouda, M. Coughlan, P. McKenna, P. Lenehan, M. Foley, P. Kelehan, P. Ravichandran, M. Kelly, A. Conroy, C. Fitzpatrick, D. Egan, C. L. Regan, B. V. McAdam, P. McParland, G. A. FitzGerald, D. J. Fitzgerald, S. C. Sharma, K. Foran, C. Barry-Kinsella, R. F. Harrison, F. J. Gillespie, P. O’Mahony, M. Boyle, M. J. White, F. Donohoe, Y. Birrane, M. Naughton, R. B. Fitzsimons, M. Piracha, S. McConkey, E. Griffin, E. Hayes, T. Clarke, N. Parfrey, K. Butler, A. J. Malone, P. J. Kearney, P. F. Duggan, A. Lane, R. Keville, M. Turner, S. Barry, D. Sloan, S. Gallagher, M. Darby, P. Galligan, J. Stack, N. Walsh, M. O’Sullivan, M. Fitzgerald, D. Meagher, S. Browne, C. Larkin, P. Casey, E. O’Callaghan, S. Rooney, E. Walsh, M. Morris, T. Burke, M. Roe, C. Maher, M. Wrigley, M. Gill, M. Burgess, E. Corcoran, D. Walsh, B. Gilmer, C. B. Hayes, L. Thornton, J. Fogarty, R. Lyons, M. O’Connor, V. Delaney, K. Buckley, D. Lillis, V. Delany, C. Hayes, P. Dack, D. Igoe, H. J. O’Neill, P. Kelly, D. McKeown, L. Clancy, G. Varghese, S. Hennessy, J. J. Gilmartin, K. Birthistle, D. Carrington, H. Maguire, P. Atkinson, C. Foley-Nolan, M. Lynch, B. Cryan, D. Whyte, C. Conlon, V. Kucinskas, U. Usinskiene, I. Sakalyte, E. Dawson, K. Molloy, N. Goulden, J. Doyle, E. Lawlor, M. G. Harrington, N. El-Nageh, M. -L. Nolan, J. O’Riordan, G. Judge, G. Crotty, T. Finch, M. Borton, T. Barnes, O. Gilligan, G. Lee, R. Limmer, M. Madden, C. Bergin, A. O’Leary, F. Mulcahy, F. Wallis, M. Glennon, M. Cormican, U. NiRiain, M. Heiginbothom, F. Gannon, T. Smith, C. O’Sullivan, R. Hone, D. A. Caugant, C. A. P. Fijen, E. J. Van Schalkwyk, G. J. Coetzee, U. Ni Riain, M. G. Cormican, L. Park, J. Flynn, V. Regazzoli, M. Hayes, G. Nicholson, P. Higgins, N. Flynn, G. Corbett-Feeney, D. J. Conway, N. J. O’Higgins, S. Rajendiran, J. Byrne, E. Kilfeather, P. Dingle, M. Hunter, S. K. Al-Ghazal, P. Stanley, J. Palmer, A. Hong, P. Saxby, D. Sheehan, I. Regan, J. O’Mullane, M. Ni Chaoimh, M. Leahy, J. J. Heffron, M. Lehane, C. Keohane, N. O’Leary, M. Sheehan, E. Renny-Walsh, M. J. Whelton, C. T. Doyle, J. Webster, N. Benjamin, S. FitzGerald, J. S. Chadha, M. G. FitzGerald, G. R. FitzGerald, L. Hemeryck, P. McGettigan, J. Golden, N. Arthur, S. Y. Wen, P. Deegan, T. Cooke, G. I. Adebayo, P. Gaffney, M. Sinnot, D. O’Riordan, T. Hayes, C. M. O’Connor, M. X. FitzGerald, C. Costello, G. Finlay, J. Hayes, C. O’Connor, K. McMahon, S. Hone, J. Robertson, R. Coakley, S. O’Neill, M. Walsh, J. McCarthy, D. Lannon, A. E. Wood, R. Sharkey, E. Mulloy, M. Long, I. Kilgallen, V. Tormey, S. Horne, T. Feeney, Ó. Ó Muiré, M. J. Griffin, D. Hughes, A. Knaggs, D. Magee, C. McCrory, B. March, D. Phelan, M. White, J. Fabry, D. Buggy, C. Cooney, E. Aziz, D. O’Keefe, A. J. McShane, J. Boylan, E. Tobin, C. Motherway, F. Colreavy, N. Denish, R. Dwyer, A. Bergin, K. O’Brien, R. MacSullivan, K. D. Carson, W. P. Blunnie, D. C. Moriarty, B. Kinirons, B. Lyons, N. Cregg, W. Casey, K. P. Moore, S. A. Colbert, C. Ecoffey, D. O’Gorman, J. Fitzgerald, P. Diamond, M. B. Codd, D. D. Sugrue, J. Kellett, M. Tighe, C. J. McKenna, J. Galvin, H. A. McCann, A. Scallon, A. Fraser, M. Norton, G. Tomkin, I. Graham, A. Byrne, M. Maher, N. Moran, D. Fitzgerald, D. O’Callaghan, D. Coyle, A. G. Nugent, C. McGurk, G. D. Johnston, A. Nugent, B. Silke, N. Murphy, L. Jennings, D. Pratico, C. Doyle, T. Hennessy, H. McCann, D. Sugrue, S. Donnelly, A. Hennessy, C. Hartigan, D. MacDonald, S. Blake, D. McDonald, D. Dominque, S. R. McMechan, G. MacKenzie, J. Allen, G. T. Wright, G. J. Dempsey, M. Crawley, J. Anderson, A. A. J. Adgey, M. T. Harbinson, N. P. S. Campbell, C. M. Wilson, P. K. Ellis, E. M. McIlrath, A. McShane, T. V. Keaveny, K. Rabenstein, F. Scheller, D. Pfeiffer, C. Urban, I. Moser, G. Jobst, A. Manz, S. Verpoorte, F. Dempsey, D. Diamond, M. Smyth, E. Dempsey, V. Hamilton, J. Twomey, R. Crowley, L. Fenelon, F. Walsh, J. McCann, P. McDonagh, E. McGovern, D. Luke, K. Crowley, D. Mannion, D. Murphy, K. Clarkson, E. Carton, I. Leonard, D. O’Toole, M. Staunton, M. Griffin, D. Owens, P. Collins, A. Johnson, G. H. Tomkin, N. A. Herity, J. D. Allen, R. O’Moore, G. M. Crotty, M. DeArce, K. Nikookam, P. Keenan, D. Cregan, N. O’Meara, S. Forman, D. A. Cusack, and B. Farrell
- Subjects
medicine.medical_specialty ,business.industry ,Family medicine ,medicine ,MEDLINE ,General Medicine ,business - Published
- 1995
- Full Text
- View/download PDF
6. Irish Thoracic Society: Proceeds of Annual Scientific Meeting held Friday & Saturday 8th & 9th November, 1996
- Author
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R. Coakley, S. O’Neill, P. Glynn, G. A. Finlay, K. J. Russell, K. McMahon, E. M. D’Arcy, J. B. Masterson, M. X. Fitzgerald, C. M. O’Connor, L. R. O’Driscoll, L. P. A. McGarvey, P. Forsythe, L. G. Heaney, J. MacMahon, M. Ennis, C. Leonard, V. Tormey, C. M. Burke, L. W. Poulter, V. M. Keatings, M. X. FitzGerald, P. J. Barnes, H. R. Harty, D. R. Corfield, L. Adams, R. M. Schwartzstein, J. F. Kiely, A. Buckley, P. Shiels, P. C. Deegan, B. Maurer, W. T. McNicholas, K. A. Dunlop, B. Martin, M. Riley, M. D. Shields, I. Kilgallen, N. G. McElvaney, D. Cervantes-Laurean, N. Wehr, K. Gabriele, W. Robinson, J. Moss, R. L. Levine, V. Urbach, D. Walsh, B. Harvey, M. C. McElroy, J-F. Pittet, L. Allen, J. Wiener-Kroonish, L. G. Dobbs, D. M. O’Donnell, K. J. McMahon, C. O’Connor, P. McGuirk, B. Mahon, F. Griffin, K. H. G. Mills, R. Murphy, F. Brijker, E. Mulloy, J. W. Cohen Tervaert, J. Walshe, R. C. Lowry, D. R. T. Shepherd, L. A. Gamble, C. Carton, R. Memon, D. Winter, A. Chan, T. Aherne, P. O’Reilly, J. A. Harbison, S. O’Callaghan, M. Keane, M. McKenna, S. Woods, A. Lamon, J. Faul, M. Murphy, J. Porszasz, M. P. K. J. Engelen, B. Brundage, K. Wasserman, M. Sweeney, R. G. O’Regan, P. McLoughlin, V. Honner, B. Sinnott, D. S. McGrath, J. Kiely, B. Cryan, C. P. Bredin, C. Shortt, M. Stack, N. Kelleher, J. McRedmond, N. Mulkerji, V. Keatings, G. M. Boylan, L. J. M. Cross, S. Davern, T. J. McDonnell, J. L. Kiely, G. Lawless, S. Cunningham, J. Lordan, L. Clancy, P. Manning, P. Plunkett, D. Donaghy, F. Ben Musbah, B. G. Loftus, R. Rutherford, S. N. E. Watson, J. J. Gilmartin, M. Henry, G. Mullins, and N. Brennan
- Subjects
medicine.medical_specialty ,Irish ,business.industry ,Ophthalmology ,language ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Library science ,Medicine ,General Medicine ,business ,language.human_language - Abstract
The abstract is included in the text.
- Published
- 1998
7. Neutrophil CD11b and soluble ICAM-1 and E-selectin in community acquired pneumonia.
- Author
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Glynn P, Coakley R, Kilgallen I, and O'Neill S
- Subjects
- APACHE, Adolescent, Adult, Aged, Aged, 80 and over, Aging immunology, Community-Acquired Infections metabolism, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Humans, Middle Aged, Up-Regulation, E-Selectin metabolism, Intercellular Adhesion Molecule-1 metabolism, Macrophage-1 Antigen metabolism, Neutrophils metabolism, Pneumonia, Bacterial metabolism
- Abstract
It was hypothesized that there would be an upregulation of systemic neutrophil CD11b expression in pneumonia. Expression of CD11b and concentrations of soluble intercellular adhesion molecule (ICAM)-1 and E-selectin were evaluated as potential surrogate markers of the severity of pneumonia. Possible age-related immunosenescence in relation to neutrophil CD11b expression in elderly patients with pneumonia was examined for. In patients with community-acquired pneumonia (n = 36) neutrophil CD11b expression was measured by flow cytometry and soluble ICAM-1 and E-selectin concentrations by enzyme-linked immunosorbent assay. An upregulation of neutrophil CD11b expression and increased soluble adhesion molecule concentrations on admission were confirmed, but the concentrations did not correlate with patient Acute Physiology and Chronic Health Evaluation II scores. Neutrophil CD11b expression was similar between elderly (age range 70-100 yrs) and younger (age range 18-70 yrs) patients with pneumonia. In conclusion, there is evidence of neutrophil and endothelial cell activation in pneumonia as indicated by upregulation of CD11b and increased soluble intercellular adhesion molecule and E-selectin, however, they do not appear to be good surrogate markers of severity of infection. Advanced age does not influence adhesion molecule expression in pneumonia.
- Published
- 1999
8. Circulating interleukin 6 and interleukin 10 in community acquired pneumonia.
- Author
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Glynn P, Coakley R, Kilgallen I, Murphy N, and O'Neill S
- Subjects
- APACHE, Adult, Age Distribution, Aged, Community-Acquired Infections metabolism, Enzyme-Linked Immunosorbent Assay methods, Humans, Middle Aged, Interleukin-10 metabolism, Interleukin-6 metabolism, Pneumonia metabolism, Systemic Inflammatory Response Syndrome metabolism
- Abstract
Background: Inflammatory cytokine concentrations correlate with severity of sepsis. We hypothesised that patients with community acquired pneumonia (CAP) associated with systemic inflammatory response syndrome (SIRS) would have greater interleukin 6 (IL-6) production due to activation of the inflammatory cytokine cascade, matched by a significant anti-inflammatory cytokine response. Interleukin 10 (IL-10) was evaluated as a potential surrogate marker of severity of sepsis in CAP and age related impairment of the cytokine response was studied in elderly patients with CAP., Methods: Circulating immunoreactive IL-6 and IL-10 levels were measured in 38 patients with CAP subdivided into a group fulfilling the criteria for SIRS (n = 28) and a non-SIRS group (n = 10) in a variety of age groups and correlated with APACHE II scores., Results: 80% had circulating IL-6 levels (median 46.7 pg/ml, range 4.6-27,000) and 60% had circulating IL-10 levels (median 15.5 pg/ml, range 2.5-765). Concentrations of both were significantly increased in patients with SIRS compared with non-SIRS patients. Those with activation of the inflammatory cytokine cascade (IL-6 positive) produced more IL-10 than IL-6 negative patients. Older patients had a similar cytokine response. Both cytokines correlated positively with APACHE II scores., Conclusions: This is the first demonstration of circulating IL-10 in CAP. A greater counter-inflammatory response in patients with SIRS and in IL-6 positive patients suggests a potential immunomodulatory role for IL-10 in controlling the inflammatory cytokine response in CAP. IL-10 concentrations correlate with severity of illness in CAP and may be of prognostic importance. There is no age related impairment in the cytokine response.
- Published
- 1999
- Full Text
- View/download PDF
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