Author: "I. Franzetti" - Searchworks@Jio Institute Digital Library Search Results

33 results on '"I. Franzetti"'

1. Quality of Life, Wishes, and Needs in Women with Gestational Diabetes: Italian DAWN Pregnancy Study

Author: A. Lapolla, G. Di Cianni, A. Di Benedetto, I. Franzetti, A. Napoli, L. Sciacca, E. Torlone, L. Tonutti, E. Vitacolonna, and D. Mannino
Subjects: Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: The DAWN (Diabetes Attitudes, Wishes and Needs) study is a survey promoted by the International Diabetes Federation to recognize the perceptions and attitudes of people suffering from diabetes mellitus. In this context, we evaluated the quality of life of Italian and immigrant women with gestational diabetes mellitus (GDM). Information was gathered using a structured questionnaire for patients’ self-compilation. In a 3-month period, a 51-item questionnaire was submitted to 198 Italians and 88 immigrants (from 27 different foreign nationalities). Italian women were older and had higher education than the immigrants. 60% of the Italians and 38% of the immigrants had a family history of diabetes mellitus. In both groups, the diagnosis of GDM caused anxiety; one-third of women feared their child could contract diabetes at delivery and/or have congenital malformations. Some women had trouble in following treatment regimens: the major concern being dietary advice and blood glucose testing. Most women were satisfied (34%) or highly satisfied (60%) with the quality of care, although the degree of cooperation between diabetes specialists and gynaecologists was considered sometimes unsatisfactory. In order to optimize maternal and foetal outcomes, educational projects and improved communication between patients and the healthcare provider team are recommended.
Published: 2012
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2. Rationale and design of the DARWIN-T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes)

Author: G.P. Fadini, G. Zatti, A. Consoli, E. Bonora, G. Sesti, A. Avogaro, G. Formoso, D. Antenucci, G. Grossi, A. Pucci, F. Andreozzi, L. Indrieri, G. Capobianco, A. Gatti, R. Bonadonna, I. Zavaroni, A. Dei Cas, G. Felace, P. Li Volsi, R. Buzzetti, G. Leto, F. D'Angelo, S. Morano, A. Giaccari, G. Sorice, E. Orsi, A. Carlo Bossi, F. Querci, E. Duratorre, C. Malagola, I. Franzetti, P. Silvia Morpurgo, M. Boemi, M. Petrelli, G. Aimaretti, I. Karamouzis, F. Cavalot, G. Saglietti, G. Gruden, E. Devangelio, G. Cazzetta, O. Lamacchia, S. Cervone, L. Frittitta, S. Arena, A. Di Benedetto, S. Piro, C. Giordano, M. Rizzo, R. Chianetta, C. Mannina, A. Solini, A. Natali, R. Anichini, F. Dotta, B. Fattor, M. Cigolini, N. Simioni, V. Frison, M. Poli, A. Lapolla, N. Cristiano Chilelli, and C. Vinci
Subjects: Research design, medicine.medical_specialty, Nutrition and Dietetics, business.industry, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), 030209 endocrinology & metabolism, Retrospective cohort study, Evidence-based medicine, 030204 cardiovascular system & hematology, Crowdsourcing, Marketing authorization, law.invention, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Randomized controlled trial, chemistry, law, Medicine, Outpatient clinic, Dapagliflozin, Cardiology and Cardiovascular Medicine, business, Intensive care medicine
Abstract: Background Randomized controlled trials (RCTs) in the field of diabetes have limitations inherent to the fact that design, setting, and patient characteristics may be poorly transferrable to clinical practice. Thus, evidence from studies using routinely accumulated clinical data are increasingly valued. Aims We herein describe rationale and design of the DARWIN-T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes), a multicenter retrospective nationwide study conducted at 50 specialist outpatient clinics in Italy and promoted by the Italian Diabetes Society. Data synthesis The primary objective of the study is to describe the baseline clinical characteristics (particularly HbA1c) of patients initiated on dapagliflozin from marketing authorization approval to the end of 2016. Secondary and exploratory objectives will evaluate the changes in glycaemic and extraglycaemic efficacy parameters after initiation of dapagliflozin or after initiation of comparator glucose lowering medications (DPP-4 inhibitors, gliclazide extended release, and long-acting GLP-1 receptor agonists). An automated software will extract relevant data from the same electronic chart system at all centres, thereby minimizing data treatment and human intervention. Conclusion The study is expected to collect an enormous dataset of information on dapagliflozin- and comparator-using patients. After study completion, the Italian Diabetes Society will launch an open crowdsourcing call on the DARWIN-T2D database, challenging diabetes researchers to apply their ideas and approaches to address new unmet needs and knowledge gaps in diabetes. We believe this will move DARWIN-T2D to the next generation of real world studies.
Published: 2017
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3. Author response for 'Similar effectiveness of dapagliflozin versus GLP‐1 receptor agonists on combined endpoints in routine clinical practice. A multicenter retrospective study'

Author: Daniele Bottigliengo, Carmela Vinci, Veronica Sciannameo, Paola Berchialla, Angelo Avogaro, Gian Paolo Fadini, Raffaella Buzzetti, I. Franzetti, Paola D'Angelo, and Salvatore Arena
Subjects: medicine.medical_specialty, chemistry.chemical_compound, chemistry, business.industry, Internal medicine, Medicine, Retrospective cohort study, Routine clinical practice, Dapagliflozin, business, Glucagon-like peptide 1 receptor
Published: 2019
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4. Masked Hypertension in Type 2 Diabetes MellitusRelationship With Left-Ventricular Structure and Function

Author: E. Nicolini, Chiara Marchesi, Francesco Solbiati, Luigina Guasti, I Franzetti, Andrea Maria Maresca, Patrizio Marnini, Emanuela Laurita, Achille Venco, Monica Gianni, and Anna Maria Grandi
Subjects: Male, medicine.medical_specialty, Heart Ventricles, Diastole, Blood Pressure, Type 2 diabetes, Ventricular Dysfunction, Left, Risk Factors, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Humans, Ventricular remodeling, Antihypertensive Agents, Ventricular Remodeling, business.industry, Case-control study, Type 2 Diabetes Mellitus, Blood Pressure Monitoring, Ambulatory, Middle Aged, medicine.disease, Circadian Rhythm, Masked Hypertension, Blood pressure, Diabetes Mellitus, Type 2, Cardiovascular Diseases, Echocardiography, Case-Control Studies, Hypertension, Cardiology, Female, business
Abstract: To evaluate in type 2 diabetes mellitus the relationship between masked hypertension (MH) and left ventricular (LV) morpho-functional characteristics.Using 24-hour BP monitoring and echocardiography, we evaluated 71 type 2 diabetic patients, without overt cardiac disease and never treated with antihypertensive drugs: 45 normotensive subjects with clinic BP130/85 mmHg and 26 sustained hypertensives (SH)(clinic BPor = 140 and/or 90 mmHg and 24-hour BPor =125 and/or 80 mmHg), matched for age, gender, BMI and duration of diabetes with clinically normotensive patients. MH was diagnosed with clinic BP130/85 mmHg and 24-hour BPor =125 and/or 80 mmHg.Among clinically normotensive patients, 21 (47%) had MH and 24 were true normotensive (NT, 24-hour BP125/80 mmHg). LV mass increased from NT to MH to SH (p0.001); the parameters of LV diastolic function were similar between MH and SH and significantly lower than in NT.In type 2 diabetic patients with clinic BP130/85 mmHg, MH is frequent and is associated with LV remodelling characterized by increased myocardial mass and preclinical impairment of LV diastolic function; the remodelling is qualitatively and for some aspects also quantitatively similar to that found in sustained hypertensive patients. Therefore it would be useful to look for MH in diabetic subjects with clinic BP130/85 mmHg, who, following the guidelines, are not entitled to antihypertensive treatment: the finding of MH could identify a subgroup of patients at higher cardiovascular risk and therefore needing a prompt antihypertensive treatment.
Published: 2007
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5. Effect of Glycemic Control on Left Ventricular Diastolic Function in Type 1 Diabetes Mellitus

Author: Anna Maria Grandi, M Bernasconi, Luigina Guasti, Eliana Piantanida, Andrea Maria Maresca, I Franzetti, Achille Venco, and Patrizio Marnini
Subjects: Adult, Blood Glucose, Male, medicine.medical_specialty, Heart disease, Systole, Diastole, Body Mass Index, Ventricular Dysfunction, Left, chemistry.chemical_compound, Internal medicine, Diabetes mellitus, Image Processing, Computer-Assisted, medicine, Humans, Hypoglycemic Agents, Insulin, Prospective Studies, Glycemic, Glycated Hemoglobin, Type 1 diabetes, business.industry, Blood Pressure Monitoring, Ambulatory, medicine.disease, Diabetes Mellitus, Type 1, Blood pressure, chemistry, Echocardiography, Cardiology, Female, Glycated hemoglobin, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies
Abstract: Left ventricular (LV) diastolic dysfunction is a main feature of diabetic heart disease. The aim of this prospective study was to evaluate the influence of glycemic control on diastolic function in type 1 diabetes mellitus. Thirty-six normotensive (24-hour blood pressure130/80 mm Hg) subjects with inadequately controlled (glycated hemoglobin7%) type 1 diabetes, without clinically detectable heart disease, were enrolled. After the basal evaluation, insulin therapy was modified to improve glycemic control. Glycated hemoglobin, LV echocardiography, 24-hour blood pressure monitoring, and laboratory tests were repeated after 6 months in all patients and after 12 months in 27 patients. At the basal evaluation, LV anatomy and systolic function were normal in all, and diastolic function was impaired in 14 patients. After 6 months, the mean values of body mass index, 24-hour blood pressure, and LV anatomy and systolic function were unchanged; mean glycated hemoglobin was decreased (p0.001), and mean values of diastolic parameters were significantly improved. After 12 months, the mean values of all blood pressure, metabolic, and LV parameters were unchanged. Percent changes of diastolic parameters were inversely correlated with percent changes of glycated hemoglobin, considering changes from the basal to the 6-month evaluation, as well as changes from the 6- to the 12-month evaluation. In conclusion, in normotensive patients with type 1 diabetes, a close relation was found between glycemic control and LV diastolic function, which improves when glycemic control improves. Therefore, diastolic dysfunction can be prevented or reversed, at least partly, by tight glycemic control.
Published: 2006
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6. QUALITY OF LIFE AND TREATMENT SATISFACTION IN PATIENTS WITH TYPE 1 DIABETES: A COMPARISON BETWEEN CONTINUOUS SUBCUTANEOUS INSULIN INJECTION AND MULTIPLE DAILY INJECTIONS

Author: Nicolucci A, Maione A, Franciosi M, Amoretti R, Busetto R, Capani F, Bruttomesso D, Di Bartolo P, Girelli A, Leonetti F, Morviducci L, Ponzi P, VitacolonnaE on behalf of the EQuality Study Group:LV Cassano, N. Tota Ospedale Generale Regionale Miulli, Acquaviva delle Fonti, V. Cherubini, A. Iannilli Università Politecnica di Ancona, AO G. Salesi, Ancona, A. Corsi, P. Ponzani UOC Genova Ponente, SO La Colletta, Arenzano, V. Montani, P. Di Berardino PO di Atri, M. Velussi Casa di Cura Pineta del Carso, Aurisina, F. Giorgino, V. Gigantelli Università degli Studi di Bari, G. Beltramello, A. Pianta CAD Bassano Bassano del Grappa, R. Trevisan, G. Lepore Ospedali Riuniti di Bergamo, G. Forlani, G. Marchesini Università degli Studi di Bologna, D. Crazzolara, M. Marchesi Ospedale di Bolzano, E. Zarra, B. Agosti Spedali Civili di Brescia, G. Careddu Ospedale SS Prosperie Caterina, Camogli, L. Tomaselli, R. Vigneri Ospedale Garibaldi Nesima, Catania, M. Agrusta, V. Di Blasi PO di Cava dei Tirreni, S. Tumini, MT Anzellotti / E. Vitacolonna, F. Capani Università G. D’Annunzio, Chieti e. Pescara, P. Ruggeri Azienda Istituti Ospedalieri, Cremona, P. Foglini, M. Rossana Ospedale A. Murri, Fermo, S. Toni, MF Reali AO Universitaria degli Studi Meyer, Firenze, M. Nizzoli, S. Aquati Ospedale Morgagni, Forlì, G. d'Annunzio, N. Minuto Istituto G. Gaslini, Genova, L. Cataldi, C. Bordone AO Università San Martino, R. Iannarelli, F. Sciarretta PO San Salvatore, L'Aquila, M. Tagliaferri, MA Lezzi Ospedale G. Vietri, Larino, L. Sciangula, A. Ciucci Ospedale di Mariano Comense, M. Bonomo, E. Meneghini AO Ospedale Niguarda Ca' Granda, Milano, G. Mariani, P. Colapinto AO San Carlo Borromeo, G. Testori, P. Rampini AO Fatebenefratelli e. Oftalmico, R. Bonfanti, F. Meschi / G. Galimberti, A. Laurenzi Istituto Scientifico Ospedale San Raffaele, A. Veronelli, C. Mauri Ospedale San Paolo, C. Tortul, AM Cernigoi Ospedale San Paolo, Monfalcone, ME De Feo, M. Piscopo AORN A. Cardarelli, Napoli, G. Annuzzi, L. Bozzetto / A. Franzese, P. Buono / S. Turco, AA Turco AOU Università Federico II, F. Prisco, Seconda Università di Napoli, M. Trovati, P. Massucco AS Ospedale San Luigi Gonzaga, Orbassano, S. Costa, M. Dal Pos Università degli Studi di Padova, V. Provenzano, L. Strazzera Ospedale Civico di Partitico, Palermo, G. Ridola Poliambulatorio Oreto Guadagna, E. Torlone, M. Orsini Federici Università degli Studi di Perugia, A. Bertolotto, M. Aragona AO Universitaria Pisana, Pisa, P. Di Bartolo, F. Pellicano AUSL Provincia di Ravenna, V. Manicardi, M. Michelini Ospedale di Montecchio, Reggio Emilia, M. Parenti, AC Babini Ospedale degli Infermi, Rimini, P. Borboni, A. Di Flaviani / ML Manca Bitti, S. Piccinini AO Universitaria Policlinico Tor Vergata, Roma, A. Clementi, C. Tubili – AO San Camillo Forlanini, C. Suraci, S. Carletti Ospedale Sandro Pertini, ASL RMB, A. Moretti, M. Maiello F. Leonetti, VC Iannucci N. Sulli, B. Shashaj Università La Sapienza, Policlinico Umberto I, D. Fava, F. Massimiani AO S. Giovanni Addolorata, P. Pozzilli, S. Manfrini Università Campus Bio Medico, S. Manfrini, C. Landi ASUR Marche, Zona Territoriale n. 4, Senigallia, I. Tanganelli Università degli Studi di Siena, G. Grassi, M. Tomelini ASO San Giovanni Battista di Torino, R. De Luca, L. Corgiat Mansin Ospedale Oftalmico ASL 1, Torino, R. Candido, E. Manca ASS 1 Triestina, Trieste, L. Tonutti, C. Noacco AO Universitaria, Udine, I. Franzetti, P. Marnini AO Universitaria, Varese, IAFUSCO, Dario, Nicolucci, A, Maione, A, Franciosi, M, Amoretti, R, Busetto, R, Capani, F, Bruttomesso, D, Di Bartolo, P, Girelli, A, Leonetti, F, Morviducci, L, Ponzi, P, VitacolonnaE on behalf of the EQuality Study Group:LV, Cassano, N., Tota Ospedale Generale Regionale Miulli, Acquaviva delle, Fonti, V., Cherubini, A., Iannilli Università Politecnica di Ancona, AO G., Salesi, Ancona, A., Corsi, P., Ponzani UOC Genova Ponente, SO La, Colletta, Arenzano, V., Montani, P., Di Berardino PO di Atri, M., Velussi Casa di Cura Pineta del Carso, Aurisina, F., Giorgino, V., Gigantelli Università degli Studi di Bari, G., Beltramello, A., Pianta CAD Bassano Bassano del Grappa, R., Trevisan, G., Lepore Ospedali Riuniti di Bergamo, G., Forlani, G., Marchesini Università degli Studi di Bologna, D., Crazzolara, M., Marchesi Ospedale di Bolzano, E., Zarra, B., Agosti Spedali Civili di Brescia, G., Careddu Ospedale SS Prosperie Caterina, Camogli, L., Tomaselli, R., Vigneri Ospedale Garibaldi Nesima, Catania, M., Agrusta, V., Di Blasi PO di Cava dei Tirreni, S., Tumini, MT Anzellotti / E., Vitacolonna, F. Capani Università G., D’Annunzio, Chieti e., Pescara, P., Ruggeri Azienda Istituti Ospedalieri, Cremona, P., Foglini, M. Rossana Ospedale A., Murri, Fermo, S., Toni, MF Reali AO Universitaria degli Studi, Meyer, Firenze, M., Nizzoli, S., Aquati Ospedale Morgagni, Forlì, G., D'Annunzio, N. Minuto Istituto G., Gaslini, Genova, L., Cataldi, C., Bordone AO Università San Martino, R., Iannarelli, F., Sciarretta PO San Salvatore, L'Aquila, M., Tagliaferri, MA Lezzi Ospedale G., Vietri, Larino, L., Sciangula, A., Ciucci Ospedale di Mariano Comense, M., Bonomo, E., Meneghini AO Ospedale Niguarda Ca' Granda, Milano, G., Mariani, P., Colapinto AO San Carlo Borromeo, G., Testori, P. Rampini AO Fatebenefratelli e., Oftalmico, R., Bonfanti, F. Meschi / G., Galimberti, A., Laurenzi Istituto Scientifico Ospedale San Raffaele, A., Veronelli, C., Mauri Ospedale San Paolo, C., Tortul, AM Cernigoi Ospedale San, Paolo, Monfalcone, ME De, Feo, M. Piscopo AORN A., Cardarelli, Napoli, G., Annuzzi, L. Bozzetto / A., Franzese, P. Buono / S., Turco, AA Turco AOU Università Federico, Ii, F., Prisco, Iafusco, Dario, Seconda Università di, Napoli, M., Trovati, P., Massucco AS Ospedale San Luigi Gonzaga, Orbassano, S., Costa, M., Dal Pos Università degli Studi di Padova, V., Provenzano, L., Strazzera Ospedale Civico di Partitico, Palermo, G., Ridola Poliambulatorio Oreto Guadagna, E., Torlone, M., Orsini Federici Università degli Studi di Perugia, A., Bertolotto, M., Aragona AO Universitaria Pisana, Pisa, P., Di Bartolo, F., Pellicano AUSL Provincia di Ravenna, V., Manicardi, M., Michelini Ospedale di Montecchio, Reggio, Emilia, M., Parenti, AC Babini Ospedale degli, Infermi, Rimini, P., Borboni, A., Di Flaviani / ML Manca Bitti, S., Piccinini AO Universitaria Policlinico Tor Vergata, Roma, A., Clementi, C., Tubili – AO San Camillo Forlanini, C., Suraci, S., Carletti Ospedale Sandro Pertini, Asl, Rmb, A., Moretti, M. Maiello F., Leonetti, VC Iannucci N., Sulli, B., Shashaj Università La Sapienza, Policlinico Umberto, I, D., Fava, F. Massimiani AO S., Giovanni Addolorata, P., Pozzilli, S., Manfrini Università Campus Bio Medico, S., Manfrini, C., Landi ASUR Marche, Zona Territoriale n., 4, Senigallia, I., Tanganelli Università degli Studi di Siena, G., Grassi, M., Tomelini ASO San Giovanni Battista di Torino, R., De Luca, L., Corgiat Mansin Ospedale Oftalmico ASL 1, Torino, R., Candido, E., Manca ASS 1 Triestina, Trieste, L., Tonutti, C., Noacco AO Universitaria, Udine, I., Franzetti, P., Marnini AO Universitaria, and Varese
Published: 2007

7. Quality of Life, Wishes, and Needs in Women with Gestational Diabetes: Italian DAWN Pregnancy Study

Author: Elisabetta Torlone, Laura Sciacca, Angela Napoli, Annunziata Lapolla, L. Tonutti, I. Franzetti, A. Di Benedetto, Ester Vitacolonna, Domenico Mannino, and G. Di Cianni
Subjects: medicine.medical_specialty, Pediatrics, Pregnancy, lcsh:RC648-665, Article Subject, Endocrine and Autonomic Systems, business.industry, Endocrinology, Diabetes and Metabolism, Alternative medicine, Context (language use), medicine.disease, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Gestational diabetes, GESTATIONAL DIABETES, Endocrinology, Quality of life, Diabetes mellitus, Family medicine, medicine, Clinical Study, Anxiety, medicine.symptom, Family history, business
Abstract: The DAWN (Diabetes Attitudes, Wishes and Needs) study is a survey promoted by the International Diabetes Federation to recognize the perceptions and attitudes of people suffering from diabetes mellitus. In this context, we evaluated the quality of life of Italian and immigrant women with gestational diabetes mellitus (GDM). Information was gathered using a structured questionnaire for patients’ self-compilation. In a 3-month period, a 51-item questionnaire was submitted to 198 Italians and 88 immigrants (from 27 different foreign nationalities). Italian women were older and had higher education than the immigrants. 60% of the Italians and 38% of the immigrants had a family history of diabetes mellitus. In both groups, the diagnosis of GDM caused anxiety; one-third of women feared their child could contract diabetes at delivery and/or have congenital malformations. Some women had trouble in following treatment regimens: the major concern being dietary advice and blood glucose testing. Most women were satisfied (34%) or highly satisfied (60%) with the quality of care, although the degree of cooperation between diabetes specialists and gynaecologists was considered sometimes unsatisfactory. In order to optimize maternal and foetal outcomes, educational projects and improved communication between patients and the healthcare provider team are recommended.
Published: 2012

8. Quality of life and treatment satisfaction in adults with Type 1 diabetes: a comparison between continuous subcutaneous insulin infusion and multiple daily injections

Author: A. Nicolucci, A. Maione, M. Franciosi, R. Amoretti, E. Busetto, F. Capani, D. Bruttomesso, P. Di Bartolo, A. Girelli, F. Leonetti, L. Morviducci, P. Ponzi, E. Vitacolonna, L. V. Cassano, N. Tota, V. Cherubini, A. Iannilli A. Corsi, P. Ponzani, V. Montani, P. Di Berardino, M. Velussi, F. Giorgino, V. Gigantelli, G. Beltramello, A. Pianta, R. Trevisan, G. Lepore, G. Forlani, G. Marchesini, D. Crazzolara, M. Marchesi, E. Zarra, B. Agosti, G. Careddu, L. Tomaselli, R. Vigneri, M. Agrusta, V. Di Blasi, S. Tumini, M. T. Anzellotti, P. Ruggeri, P. Foglini, M. Rossana, A Murri, S. Toni, M. F. Reali, M. Nizzoli, S. Aquati, G. d’Annunzio, N. Minuto, L. Cataldi, C. Bordone, R. Iannarelli, F. Sciarretta, M. Tagliaferri, M. A. Lezzi, L. Sciangula, A. Ciucci, M. Bonomo, E. Meneghini, G. Mariani, P. Colapinto, G. Testori, P. Rampini, R. Bonfanti, F. Meschi, G. Galimberti, A. Laurenzi, A. Veronelli, C. Mauri, C. Tortul, A. M. Cernigoi, M. E. De Feo, M. Piscopo, G. Annuzzi, L. Bozzetto, A. Franzese, P. Buono, S. Turco, A. Turco, F. Prisco, D. Iafusco, M. Trovati, P. Massucco, S. Costa, M, V. Provenzano, L. Strazzera, G. Ridola, E. Torlone, M. Orsini Federici, A. Bertolotto, M. Aragona, F. Pellicano, V. Manicardi, M. Michelini, M. Parenti, A. C. Babini, P. Borboni, A. Di Flaviani, M. L. Manca Bitti, S. Piccinini, A. Clementi, C. Tubili, C. Suraci, S. Carletti, A. Moretti, M. Maiello, V. C. Iannucci, N. Sulli, B. Shashaj, D. Fava, F. Massimiani, P. Pozzilli, S. Manfrini, C. Landi, I. Tanganelli, G. Grassi, M. Tomelini, R. De Luca, L. Corgiat Mansin, R. Candido, E. Manca, L. Tonutti, C. Noacco, I. Franzetti, P. Marnini., Nicolucci, A., Maione, A., Franciosi, M., Amoretti, R., Busetto, E., Capani, F., Bruttomesso, D., Di Bartolo, P., Girelli, A., Leonetti, F., Morviducci, L., Ponzi, P., Vitacolonna, E., Cassano, L. V., Tota, N., Cherubini, V., Corsi, A. Iannilli A., Ponzani, P., Montani, V., Di Berardino, P., Velussi, M., Giorgino, F., Gigantelli, V., Beltramello, G., Pianta, A., Trevisan, R., Lepore, G., Forlani, G., Marchesini, G., Crazzolara, D., Marchesi, M., Zarra, E., Agosti, B., Careddu, G., Tomaselli, L., Vigneri, R., Agrusta, M., Di Blasi, V., Tumini, S., Anzellotti, M. T., Ruggeri, P., Foglini, P., Rossana, M., Murri, A, Toni, S., Reali, M. F., Nizzoli, M., Aquati, S., D’Annunzio, G., Minuto, N., Cataldi, L., Bordone, C., Iannarelli, R., Sciarretta, F., Tagliaferri, M., Lezzi, M. A., Sciangula, L., Ciucci, A., Bonomo, M., Meneghini, E., Mariani, G., Colapinto, P., Testori, G., Rampini, P., Bonfanti, R., Meschi, F., Galimberti, G., Laurenzi, A., Veronelli, A., Mauri, C., Tortul, C., Cernigoi, A. M., De Feo, M. E., Piscopo, M., Annuzzi, G., Bozzetto, L., Franzese, A., Buono, P., Turco, S., Turco, A., Prisco, F., Iafusco, D., Trovati, M., Massucco, P., Costa, S., M, Provenzano, V., Strazzera, L., Ridola, G., Torlone, E., Orsini Federici, M., Bertolotto, A., Aragona, M., Pellicano, F., Manicardi, V., Michelini, M., Parenti, M., Babini, A. C., Borboni, P., Di Flaviani, A., Manca Bitti, M. L., Piccinini, S., Clementi, A., Tubili, C., Suraci, C., Carletti, S., Moretti, A., Maiello, M., Iannucci, V. C., Sulli, N., Shashaj, B., Fava, D., Massimiani, F., Pozzilli, P., Manfrini, S., Landi, C., Tanganelli, I., Grassi, G., Tomelini, M., De Luca, R., Corgiat Mansin, L., Candido, R., Manca, E., Tonutti, L., Noacco, C., Franzetti, I., and Marnini., P.
Subjects: multiple daily injections, Insulin pump, Adult, Male, medicine.medical_specialty, Continuous subcutaneous insulin infusion, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Injections, Subcutaneous, Insulin Glargine, Endocrinology, Patient satisfaction, Insulin Infusion Systems, Quality of life, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Insulin, Multiple daily injection, continuous subcutaneous insulin infusion, quality of life, questionnaires, type 1 diabetes, Type 1 diabetes, Questionnaire, Insulin glargine, business.industry, Middle Aged, medicine.disease, Obesity, Surgery, Insulin, Long-Acting, Diabetes Mellitus, Type 1, Patient Satisfaction, Quality of Life, Female, business, Epidemiologic Methods, medicine.drug
Abstract: Aims The aim of this case–control study was to compare quality of life (QoL) and treatment satisfaction in adults with Type 1 diabetes (T1DM) treated with either continuous subcutaneous insulin infusion (CSII) or multiple daily injections (MDI). Methods Consecutive patients aged between 18 and 55 years, and attending diabetes clinics for a routine visit, completed the Diabetes-Specific Quality-of-Life Scale (DSQOLS), the Diabetes Treatment Satisfaction Questionnaire (DTSQ) and the SF-36 Health Survey (SF-36). Case (CSII) and control subjects (MDI) were recruited in a 1 : 2 ratio. Results Overall, 1341 individuals were enrolled by 62 diabetes clinics; 481 were cases and 860 control subjects. Cases had a longer diabetes duration and were more likely to have eye and renal complications. Age, school education, occupation and HbA 1c were similar. Of control subjects, 90% followed glargine-based MDI regimens and 10% used NPH-based MDI regimens. On multivariate analysis, after adjusting for socioeconomic and clinical characteristics, scores in the following areas of the DSQOLS were higher in cases than control subjects: diet restrictions ( β = 5.96; P < 0.0001), daily hassles ( β = 3.57; P = 0.01) and fears about hypoglycaemia ( β = 3.88; P = 0.006). Treatment with CSII was also associated with a markedly higher DTSQ score ( β = 4.13; P < 0.0001) compared with MDI. Results were similar when CSII was compared separately with glargine- or NPH-based MDI regimens. Conclusions This large, non-randomized, case–control study suggests quality of life gains deriving from greater lifestyle flexibility, less fear of hypoglycaemia, and higher treatment satisfaction, when CSII is compared with either glargine-based or NPH-based MDI regimens. Diabet. Med. 25, 213–220 (2008)
Published: 2008

9. Outcome of pregnancy in type 1 diabetic patients treated with insulin lispro or regular insulin: an Italian experience

Author: R. Gentilella, Aldo Galluzzo, R. Spezia, Domenico Valle, G. Di Cianni, L. Scaldaferri, Elena Parretti, M. Songini, Claudia Santini, Roberto Anichini, Matteo Bonomo, Angela Napoli, G. Noacco, Annunziata Lapolla, L. Tonutti, M. G. Dalfrà, Andrea Rossi, Guido Menato, E. Scaldaferri, Elisabetta Torlone, Giorgio Mello, I. Franzetti, Daniela Bruttomesso, LAPOLLA A, DALFRÀ MG, SPEZIA R, ANICHINI R, BONOMO M, BRUTTOMESSO D, DI CIANNI G, FRANZETTI I, GALLUZZO A, MELLO G, MENATO G, NAPOLI A, NOACCO G, PARRETTI E, SANTINI C, SCALDAFERRI E, SCALDAFERRI L, SONGINI M, TONUTTI L, TORLONE E, GENTILELLA R, ROSSI A, and VALLE D
Subjects: medicine.medical_specialty, Pediatrics, neonatal mortality, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Birth weight, Endocrinology, Pregnancy, Internal medicine, Diabetes mellitus, Internal Medicine, Birth Weight, Humans, Hypoglycemic Agents, Insulin, Medicine, Insulin lispro, Chromatography, High Pressure Liquid, Retrospective Studies, Glycated Hemoglobin, Type 1 diabetes, Insulin Lispro, diabetes, business.industry, Infant, Newborn, nutritional and metabolic diseases, Retrospective cohort study, General Medicine, medicine.disease, malformations, pregnancy, Pregnancy Complications, Diabetes Mellitus, Type 1, Italy, Infant, Small for Gestational Age, Regular insulin, Small for gestational age, Female, business, medicine.drug
Abstract: Some studies have shown that fetal outcome observed in patients using insulin lispro is much the same as in pregnant women using regular insulin. This study aims to analyze the Italian data emerging from a multinational, multicenter, retrospective study on mothers with type 1 diabetes mellitus before pregnancy, comparing those treated with insulin lispro for at least 3 months before and 3 months after conception with those treated with regular insulin. The data collected on pregnant women with diabetes attending 15 Italian centers from 1998 to 2001 included: HbA1c at conception and during the first and third trimesters, frequency of severe hypoglycemic episodes, spontaneous abortions, mode and time of delivery, fetal malformations and mortality. Seventy-two diabetic pregnancies treated with lispro and 298 treated with regular insulin were analyzed, revealing a trend towards fewer hypoglycemic episodes in the former, who also had a significantly greater reduction in HbA1c during the first trimester. The rate of congenital malformations was similar in the offspring of the two groups of women treated with insulin lispro or regular insulin. These findings suggest that insulin lispro could be useful for the treatment of hyperglycemia in type 1 diabetic pregnant women.
Published: 2008

10. Simvastatin treatment modifies polymorphonuclear leukocyte function in high-risk individuals: a longitudinal study

Author: Catherine Klersy, Marco Cosentino, Daniela Restelli, Ramona Consuelo Maio, Giovanni Gaudio, Sergio Lecchini, Luigina Guasti, I Franzetti, Chiara Crespi, Franca Marino, Cinzia Simoni, Patrizio Marnini, Achille Venco, Anna Maria Grandi, and Mariagrazia Cimpanelli
Subjects: Male, medicine.medical_specialty, Chemokine, Simvastatin, Physiology, Neutrophils, Neutrophile, Proinflammatory cytokine, Risk Factors, Internal medicine, Human polymorphonuclear leukocytes, Internal Medicine, medicine, Humans, Interleukin 8, Longitudinal Studies, Vascular Diseases, chemistry.chemical_classification, Reactive oxygen species, biology, business.industry, Interleukin-8, Human polymorphonuclear leukocytes, Interleukin-8, Reactive oxygen species, Statins, Statins, Chemotaxis, Middle Aged, Hydroxymethylglutaryl-CoA reductase, Endocrinology, chemistry, Immunology, biology.protein, Female, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract: Background Although extensive experimental evidence supports a primary role of polymorphonuclear leukocytes (PMNs) in atherosclerosis, few data exist concerning the functional properties of these cells and their pharmacological modulation in high-risk individuals. Objective The production of the proinflammatory chemokine interleukin-8 (IL-8), migration and chemotaxis, and reactive oxygen species (ROS) generation were investigated in a longitudinal study in PMNs obtained from high-risk individuals during statin treatment. As a secondary endpoint we compared PMN function of high-risk patients with that of controls. Methods and results PMNs were isolated from 21 high-risk individuals before treatment and 3 and 30 days after the beginning of simvastatin treatment, and from healthy controls. During treatment a significant reduction was observed both in resting (P = 0.009) and N-formyl-Met-Leu-Phe (fMLP)-stimulated (P = 0.008) IL-8 production, and in the chemotactic index (P = 0.038), whereas ROS generation did not significantly change. In comparison with cells from controls, PMNs obtained from patients before starting simvastatin treatment showed higher resting and fMLP-stimulated IL-8 release (P = 0.007 and P = 0.002, respectively) and ROS generation (resting, P = 0.009; and fMLP-stimulated, P = 0.046), whereas migration and the chemotactic index did not significantly differ. Conclusions An activation of neutrophils is present in high-risk individuals, shown by the enhanced production of IL-8, and increased ROS generation. The 4-week statin treatment is able to reduce the cell capability to produce IL-8, and to decrease chemotaxis, thus affecting the proinflammatory properties of PMNs.
Published: 2006

11. 40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004

Author: S. Artigas, A V Dreval, Mark I. McCarthy, C Watson, Peter H. Bennett, M Quint, Y Ikeda, E Alpert, F Schiele, H Sekihara, Erik Gylfe, P Lowe, J Kuhlmann, Alain Golay, V Longo, Shahidul Alam Khan Akm., L G Mantovani, M Zawodniak-Szalapska, G Winkler, T Harrity, L Virág, U Johne, Kuo S-W., Linda C Tapsell, J Rodriguez, Michel Komajda, K Kankova, Carole A. Cull, M Sporna, E Estilles, U Ribel, M C Spruce, E Buzzigoli, T Prazak, J K McLaughlin, M K Lingohr, M Lim, F Calara, A Siebenhofer, G Meregalli, Roberto Anichini, A D Baron, R Kurashvili, P C Butler, G I Fantus, T. E. De Gooyer, Park Y-M., R. Walther, S Heinrich, Agnieszka Zawiejska, S Mukherjee, Nikolaos Papanas, G Wong, Ian D. Caterson, David M. Maahs, Shuichi Kaneko, Alexandra E. Butler, Francisco Javier Ampudia-Blasco, O N Kong, Attali J-R., C A Hedman, K Oshinyemi, Nicolle Müller, I C Cranston, N Okumus, M V Vlaiculescu, Balasubramanian Ravikumar, W W Cheatham, K Mukasa, K B Biswas, Annunziata Lapolla, Phil McEwan, G Mader, Gilles Chassot, Dragi Anevski, Werner A. Scherbaum, M Donath, C Hesselmann, R A Gandhi, David E. Moller, Ezio Bonifacio, C Garcia, V Ifandi, P Hornnes, Nieuwenhoven Fav., C Puech, S Pérez-Del-Pulgar, Kim S-R., G Hines, C Rubio Terrés, Michael Gaster, N. Hosszufalusi, A Scholze, Andrew A. Young, Stavros Liatis, F Hariri, S Tan, Paul Valensi, Allan E. Karlsen, J Kim, E. Moberg, J Kaiser, L Berman, G Nelson, A Altkrüger, P Kothare, D B Cook, S Doran, G. van Dijk, Shahnaz Shahinfar, Kim C-S., P Stahl, M Manousaki, S Sigrist, S K Lim, M. P. Stern, A Guberti, C Rezzani, J McKenney, Karl Thomaseth, Sofia Carlsson, M Julia, R Brillante, I Rubesova, T Darkow, E Matsumoto, Wendy M. Macfarlane, M Di Martino, G Bardini, Rossella Menghini, D Duhot, E Farcasiu, Annalisa Natalicchio, I Lindner, J Buvat, Christian L. Brand, Harry Dorchy, Iwona Pietrzak, Z T Luo, P Home, M Ekelund, Jesper Gromada, Kristine Færch, F Piarulli, H Kim, R Mentel, Zsuzsanna K. Zsengellér, Dullaart Rpf., Anton Luger, Thomas A. Pearson, V Manicardi, P Rösen, Feng Y-M., R Morganti, Lars Hansen, Demuth H-U., Haruo Kasai, A Shostak, Rudi Steffensen, G Taylor, Markolf Hanefeld, C Santini, E Hamaguchi, Roberto Miccoli, F Storms, M Cooper, Y Lee, Allison E. Aiello, P Smith, T Suehiro, K Treece, M Waluś, Timothy A Welborn, Simone Baltrusch, E Kontela, S Chai, J Crean, H Yokoyama, Johan G. Eriksson, Rafael Hernández Hernández, J Rodríguez-Saldaña, M P Tornero, G Formoso, D. Lovell, E Bingham, A Mylonakis, M Manteghetti, D Fedele, Antonio Martín-Duce, Ralph A. DeFronzo, D Salcedo, Kurt Højlund, Antonio Petrone, Sheu Whh., C Gutierrez, Flavia Pricci, S Kurita, Z G Abbas, M M Benedetti, Philippe A. Halban, Daniel J. Cox, O Ljungkvist, Justine Davies, J Palsgaard, Lars Sjöström, E Bosi, L Janin-Manificat, W. F. Kelly, M. Fernandez, E Colak, O V Mulyarchik, B Kronshage, F Lang, M Erfurth, Takashi Kadowaki, N Jendrike, U Walter, J Wishart, Y. Neye, D Kim, N Furuhashi, M Barsotti, D Florow, L Ke, L Borgquist, N C Jackson, Ffolliott M. Fisher, V Baskar, K Yoshioka, Bryan A. Wolf, G Chabrier, R Skoumal, Livio Luzi, H Kose, I Pharisien, B. Klein, H Winiarska, M C Johnson, L Griffiths, Nonna Kravchun, C Combe, Baptist Gallwitz, J Zdychova, L Skorda, Jorma Ilonen, W Gao, I N Steen, A Terrinoni, P D Ambery, W Kern, C M Kusminski, Cho M-H., Paolo Pozzilli, Louise G. Grunnet, E Schönle, David R Matthews, Robert W. Taylor, Y Cohen, Kim H-S., M P Eccles, N B Tutuncu, D McDowell, Richard M. Bergenstal, K Takamatsu, T Steiner, Jaan Palgi, Valdemar Grill, N Niculescu, G Federici, S Lehto, P. M. McKeigue, M Barone, Michael E. Trautmann, S Smirnov, J Mannion, M Eto, C Rousseau, M Conti, C S Ernest, Antonio Ceriello, D H Schweitzer, Jung E-D., Andreas Festa, Avijit Lahiri, A Shepelkevich, A Murro, A Kollmann, Jonathan R.S. Arch, R Landgraf, Son H-Y., I Engelsberger, E Agardh, S Rodríguez-Mulero, P J Kraml, K Lee, D. F. Du Toit, E Kim, G Fadini, Williams Ajk., Philip Home, M B Antcieferov, C Perlemoine, D Perrea, Song X-L., D Ruggieri, Krister Bokvist, Heidi Sørensen, Bilbao, G Yoshino, J P Taylor, Shen H-M., S M Furier, R Urquhart, J Wohlgelernter, Jianping Weng, T. Baba, Q Hong, C Silva, Castaigne J-P., M Felaco, X X Zhang, M Jaroň, Milla Rosengård-Bärlund, J G Papp, Toshio Miyata, Lervang H-H., Park M-K., I Kinalska, A Long, Oomen Phn., N Kogawa, Ippolita Patrizia Patera, S. Karadeniz, Dinesh Selvarajah, D S Chung, A Wensaas, Richard Imrich, M Recasens, J Ruxer, O Buchea, E Wilpart, S P Stepanenko, Le Ttd., H Ohgawara, Mariaconsuelo Valentini, A Mondok, M Peltonen, Marianne O. Larsen, K Chatzianagnostou, Agneta Ståhle, A L Ferrari, L Bordier, F Maingrette, A Matsuda, G Vukomanovic, Jakob D. Wikstrom, T Yamakita, E Gorostiaga, J Jin, B Gopalan, Heinz Drexel, S Hewitt, Rury R. Holman, C Dieterle, T L Ruchti, N Asatiani, M Sidira, A Iezzi, A J Sommerfield, D Châtenet, M L Olsen, R Bergemann, C Koehler, T L Kuraeva, B Balas, Christian Berne, E Santos-Mazo, G Smith, A Siejka, R Kožnarová, A Mattina, S Sheikh, A Adomeit, M Rasmussen, J. Fagerudd, N Busciantella Ricci, Nuria Vilarrasa, E Hammar, T L Thoms, L Aydın, Ron G. Rosenfeld, A Nikolajuk, R Gos, C L Morgan, H L Yu, D Dheelchand, S Ramrath, N Boudriga, Jerome I. Rotter, C Jahannault, W M Weston, Folke Lindgärde, M Hertlova, D Knight, A Monroy-Mayorga, E Pardini, A Chamson-Reig, B Franke, Janie McCluskey, Joseph Bryan, C Nikolopoulou, Christie M. Ballantyne, Fausto Santeusanio, L Pegoraro, M Lee, A Klimenko, S Jaiveer, K. Pettersson-Fernholm, Michael A. 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Liu, H, Jeong, I, Chae, M, Choi, M, Yoo, H, Kim, C, Yun, M, Na, M, Kang, Y, Kong, O, Son, S, Kim, I, Tanaka, N, Hosoi, M, Matsuyama, Y, Fukumoto, M, Yamakita, T, Yoshioka, K, Ishii, T, Sato, T, Fujii, S, Aoki, T, Shibata, T, Mizutani, N, Suzuki, J, Fowelin, J, Samuelsson, P, Brandrup wogsen, G, Okumura, K, Tokmakova, A, Staroverova, D, Antcieferov, M, Shutichina, I, Kuntchevich, G, Vriesendorp, T, Morélis, Q, Legemate, D, Schaper, F, Mainas, E, Gkioulmpasanis, I, Panagiotou, I, Vassilikos, G, Skorda, L, Sidira, M, Christoforidou, M, Alaveras, A, Artikis, V, Evdemon, E, Lechleitner, M, Koch, T, Ebenbichler, C, Sturm, W, Moretti, L, Moruzzo, D, Boldrini, E, Pandolfo, C, Kameyama, M, Iwasa, R, Cho, M, Nam, J, Huh, K, Kaplar, M, Paragh, G, Erdei, A, Csongradi, E, Garai, I, Varga, J, Galuska, L, Udvardy, M, Higa, M, Kaneko, Y, Hiroi, N, Koziarska, D, Nowacki, P, Majkowska, L, Luzniak, P, Wojciechowska luźniak, A, Tushuizen, M, Nieuwland, R, Snoeck, D, Sturk, A, Diamant, M, Aguiar, L, Bahia, L, Villela, N, Laflor, C, Conde, C, Bottino, D, Dorigo, D, Bouskela, E, Pu, S, Luo, Z, Lam, K, Dan, Q, Xu, A, Shen, J, Cheng, K, Xu, J, Thamer, C, Stefan, N, Haap, M, Heller, E, Tschritter, O, De Prado, A, Ortiz, A, Ybarra, J, Gich, I, Pou, J, Ehren, M, Roggenland, D, Reinsen, B, Klein, H, Rittig, K, Stock, J, Kocher, B, Balletshofer, B, Shon, H, Chung, D, Nakatani, Y, Matsuhisa, M, Kaneto, H, Hatazaki, M, Yoshiuchi, K, Katakami, N, Kawamori, D, Ohtoshi, K, Sakamoto, K, Matsuoka, T, Ozawa, K, Ogawa, S, Hori, M, Yamasaki, Y, Zitouni, K, Harry, D, Nourooz zadeh, J, Earle, K, Olesen, P, Franco, L, Corvaja, C, Semplicini, A, Ceylan işık, A, Arı, N, Rösen, P, Lee, I, Park, K, Jung, E, Shin, D, Jo, S, Obuobie, K, Prakash, P, Hanna, F, Lazarus, J, Varadhan, L, Gurushankar, J, James, D, Sheikh, S, Gaede, P, Zou, D, Vilarrasa, N, Perez maraver, M, Mena, E, Perez, D, Setti, G, Buckingham, R, Urbančič, V, Stefanovska, A, Bernjak, A, Ažman juvan, K, Kocijančič, A, Glowania, A, Filters, T, Fosmark, D, Torjesen, P, Kilhovd, B, Berg, T, Sandvik, L, Hanssen, K, Mentink, C, Donchenko, G, Stepanenko, S, Maingrette, F, Deng, H, Lindenmair, A, Freudenthaler, A, Baumgartner parzer, S, Nizheradze, K, Khoruzhenko, A, Tronko, N, Sheu, W, Ou, H, Shen, H, Lin, T, Wu, H, Yang, C, Mogylnytska, L, Schmoelzer, I, Davies, J, Band, M, Struthers, A, Prázný, M, Škrha, J, Kasalová, Z, Neelotpol, S, Jahan, P, Kauschke, S, Harrop, C, Schäfer, A, Widder, J, Eigenthaler, M, Walter, U, Uchimura, I, Ikebukuro, M, Kaibara, M, Hirata, M, Helal, R, Pervin, F, Yang, X, Jansson, P, Nagaev, I, Jack, M, Carvalho, E, Sunnerhagen, K, Cam, M, Cushman, S, Smith, U, Creely, S, Farmer, J, Gustafson, B, Kusminski, C, Krusinova, E, Wohl, P, Klementova, M, Lanska, V, Mcdougall, C, Kelly, I, Abbas, Z, Lutale, J, Archibald, L, Karunajeewa, H, Stingemore, N, Stuccio, G, Mcgechie, D, Muller, L, Hak, E, Goudzwaard, W, Montorsi, F, Homering, M, Sprenger, K, Goldstein, I, Asnaghi, V, Ferrari, G, Rastaldi, M, Gabellini, D, Dell'Antonio, G, Maestroni, A, Ruggieri, D, Luzi, L, Piemonti, L, Zerbini, G, Anafaroglu, I, Tutuncu, N, Sultana, M, Siddiqua, N, Iwasaki, T, Nakajima, A, Yoneda, M, Mukasa, K, Tanaka, S, and Sekihara, H
Subjects: 0303 health sciences, medicine.medical_specialty, business.industry, EASD, Endocrinology, Diabetes and Metabolism, Human physiology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Family medicine, Internal Medicine, Medicine, business, 030217 neurology & neurosurgery, 030304 developmental biology
Published: 2004

12. GLYCEMIC CONTROL IN TYPE 2 DIABETES MELLITUS: RELATIONSHIP WITH LEFT VENTRICULAR DIASTOLIC DYSFUNCTION AND MATRIX METALLOPROTEINASES

Author: Filippo Annoni, Chiara Marchesi, E. Nicolini, Anna Maria Grandi, L. Merletti, Andrea Bertolini, Alberto Passi, A.M. Maresca, Achille Venco, I Franzetti, and C. Mongiardi
Subjects: medicine.medical_specialty, Physiology, business.industry, Internal medicine, Internal Medicine, medicine, Cardiology, Type 2 Diabetes Mellitus, Left ventricular diastolic dysfunction, Matrix metalloproteinase, Cardiology and Cardiovascular Medicine, business, Glycemic
Published: 2011
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13. [Lactic acidosis and severe hyperkalemia in a diabetic patient treated with metformin and enalapril: influence of acute renal disease and drugs]

Author: I, Franzetti, P, Donnini, M, Gaiazzi, E, Mazzola, E, Zibetti, and R, Uccella
Subjects: Time Factors, Injections, Subcutaneous, Iatrogenic Disease, Acidosis, Renal Tubular, Metformin, Diabetes Mellitus, Type 2, Enalapril, Acute Disease, Hypertension, Humans, Hyperkalemia, Insulin, Acidosis, Lactic, Female, Aged, Follow-Up Studies
Abstract: A 71 year old hypertensive and non insulin-dependent diabetic patients with moderate renal insufficiency taking 500 mg/d of metformin and 5 mg/d of enalapril, developed metabolic acidosis characterized by fairly elevated anion gap, hyperchloremia, severe hyperkalemia, normal plasma level of beta-hydroxybutyric acid, absence of ketonuria and high plasma level of lactic acid. This biochemical feature allowed us to ascribe the pathogenesis of metabolic acidosis both to the increased plasma level of lactic acid and to the type IV renal tubular acidosis syndrome, the precipitating factor being an infection of urinary tract (as we assumed on the basis of the urine culture). The patient was dehydrated and lethargic; the ECG revealed the presence of nonparoxysmal junctional tachycardia. The clinical evolution was favorable thanks to the treatment with the infusion of isotonic saline solutions, mild alkalinizing solutions, low-dose regular insulin and antibiotics. It is likely that metformin and enalapril, regularly assumed by the patient, could have played a iatrogenic role even if they were taken in low dosages. This event points out the importance of complying with the indications and especially the contraindications of these drugs, to avoid life threatening complications as that one occurred in this case.
Published: 1995

14. Serum lipid pattern as severity indicator of angiographically assessed coronary artery disease

Author: R, Uccella, P, Donnini, I, Franzetti, and M, Gaiazzi
Subjects: Adult, Male, Analysis of Variance, Apolipoprotein A-I, Cholesterol, HDL, Coronary Disease, Cholesterol, LDL, Middle Aged, Coronary Angiography, Lipids, Apolipoproteins, Cholesterol, Apolipoprotein B-100, Humans, Regression Analysis, Female, Biomarkers, Triglycerides, Apolipoproteins B
Abstract: In this study we compared the relative utility of plasma lipid and apolipoprotein pattern as predictor of extent of Coronary Artery Disease as angiographically established. The lipid and apolipoprotein values were plotted in multiple stepwise analysis against coronary score determined as follows: at least 1 coronary artery system (left, anterior, descendent, circumflex, right) with a/= 25% stenosis 1 point, number of involved vessel 1, 2, 3, .... adjunctive points; sequential lesions +1 point;= %50% stenosis +1 point; 75-95 % +2 points;95% +3 points. The statistical analysis demonstrate a strong influence on extent of disease by total-cholesterol, % HDL-cholesterol on total cholesterol and by the difference between LDL and HDL-cholesterol. We conclude that, in predicting the extension of CAD, is important to know how total cholesterol is distributed in plasma apolipoprotein system.
Published: 1993

15. Effects of simvastatin on polymorphonuclear leukocyte function in high-risk patients

Author: I Franzetti, Mariagrazia Cimpanelli, Gianmario Frigo, Marco Cosentino, Giovanni Gaudio, Luigina Guasti, Daniela Restelli, Sergio Lecchini, Lorenzo Maroni, Ramona Consuelo Maio, Cinzia Simoni, Franca Marino, Patrizio Marnini, and Achille Venco
Subjects: Polymorphonuclear leukocyte, medicine.medical_specialty, High risk patients, Statin, business.industry, medicine.drug_class, N-Formylmethionine leucyl-phenylalanine, medicine.disease, Gastroenterology, chemistry.chemical_compound, Endocrinology, chemistry, Simvastatin, Cell surface receptor, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, LDL Cholesterol Lipoproteins, business, medicine.drug
Published: 2005
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16. Treatment with simvastatin reduces interleukin-8 production by polymorphonuclear leukocytes in high-risk patients

Author: Achille Venco, Mariagrazia Cimpanelli, Cinzia Simoni, Patrizio Marnini, Daniela Restelli, Sergio Lecchini, Marco Cosentino, Gianmario Frigo, Giovanni Gaudio, Luigina Guasti, Franca Marino, Ramona Consuelo Maio, Lorenzo Maroni, and I Franzetti
Subjects: Chemokine, High risk patients, Statin, biology, business.industry, medicine.drug_class, Interleukin, N-Formylmethionine leucyl-phenylalanine, medicine.disease, chemistry.chemical_compound, chemistry, Simvastatin, Diabetes mellitus, Immunology, Internal Medicine, biology.protein, medicine, Interleukin 8, business, medicine.drug
Published: 2005
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17. Mental Arithmetic Stress as a Test for Evaluation of Diabetic Sympathetic Autonomic Neuropathy

Author: G. Pozza, A. Locatelli, I. Franzetti, E. Gaudio, F. Caviezel, G. Lepore, and M. L. Maglio
Subjects: Adult, Blood Glucose, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Mental arithmetic, Basal (phylogenetics), Endocrinology, Diabetic Neuropathies, Heart Rate, Reference Values, Internal medicine, Diabetes mellitus, Heart rate, Internal Medicine, medicine, Humans, Diabetic Autonomic Neuropathy, business.industry, medicine.disease, Diabetes Mellitus, Type 1, Circulatory system, Cardiology, Female, Skin Temperature, Complication, Autonomic neuropathy, business, Mathematics, Stress, Psychological
Abstract: The effects of a 1-min mental arithmetic stress test on heart rate change were studied in 72 Type 1 diabetic patients, 36 without and 36 with diabetic autonomic neuropathy (mean age 33 and 44 yr, respectively), and in 80 matched normal subjects. Variation in hand skin temperature was also recorded in 25 normal subjects and 30 diabetic patients without and 32 with autonomic neuropathy. While mental arithmetic rapidly reduced skin temperature of normal volunteers and of patients without autonomic neuropathy, no effect was found in autonomic neuropath (a drop of 0.63 +/- 0.05 (+/- SE), 0.52 +/- 0.04 and 0.16 +/- 0.02 degrees C (p less than 0.001), respectively). In control subjects and in diabetic patients without and with autonomic neuropathy the heart rate increase was 22.9 +/- 6.8 (+/- SD), 21.4 +/- 8.4 and 7.0 +/- 3.7 beats min-1, respectively (p less than 0.001). The ratio between maximum mental arithmetic-induced heart rate and basal heart rate was 1.29 +/- 0.10, 1.24 +/- 0.10 and 1.07 +/- 0.05 (p less than 0.001) for healthy subjects, non-neuropathic patients, and neuropathic patients. Cut-off values (the low normal limit for these variables) are proposed: skin temperature 0.23 degrees C, heart rate increase 11.6 beats min-1 and heart rate ratio 1.12. Anxiety state, blood glucose concentration (excluding hypoglycaemia), body position, basal heart rate, and age did not interfere with responses to mental arithmetic stress.
Published: 1989
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18. Dapagliflozin acutely improves kidney function in type 2 diabetes mellitus. The PRECARE study.

Author: Lazzaroni E, Lunati ME, Montefusco L, Pastore I, Chebat E, Cimino V, Morpurgo PS, Muratori M, Plebani L, Bolla A, Rossi A, Vallone L, Gandolfi A, Tinari C, D'Addio F, Nasr MB, Loretelli C, Scaranna C, Bellante R, Manfrini R, Muratori F, Franzetti I, Orsi E, Gazzaruso C, Ghelardi R, Desenzani P, Genovese S, Girelli A, Folli F, Berra C, and Fiorina P
Subjects: Albuminuria drug therapy, Benzhydryl Compounds adverse effects, Blood Glucose, Glucosides, Humans, Kidney, Diabetes Mellitus, Type 2, Sodium-Glucose Transporter 2 Inhibitors therapeutic use
Abstract: Dapagliflozin has been demonstrated to improve glycemic control, blood pressure, and body weight in type 2 diabetes mellitus (T2D); indeed, it can also reduce the risk of progression to renal failure, of hospitalization for heart failure and of cardiovascular death. We aim to investigate the acute effect of Dapagliflozin on kidney function in the common clinical practice in T2D. This is a study including 1402 patients with T2D recruited from 11 centers in Lombardia, Italy, who were evaluated at baseline and after 6 months of treatment with Dapagliflozin 10 mg per day. The primary outcome of the study was the change in HbA1c, while the secondary outcomes were modification of weight, BMI, systolic and diastolic pressure, creatinine, eGFR and albuminuria status. After 24 weeks of treatment with Dapagliflozin, a reduction in Hb1Ac was observed (-0.6 ± 1.8%) as well as in BMI (-1.5 ± 5.2 kg/m 2 ). Statistically significant changes were also found for systolic and diastolic blood pressure, cholesterol and triglycerides. Interestingly, a statistically significant acute improvement of kidney function was evident. Our analyses confirm the beneficial effects of dapagliflozin after 6 months of therapy, with improvements of glycemic and lipid profiles, blood pressure, BMI. Finally, an acute positive effect on albuminuria and KIDGO classes was observed during a 6 months treatment with dapagliflozin in patients with T2D., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Ltd. All rights reserved.)
Published: 2022
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19. Similar effectiveness of dapagliflozin and GLP-1 receptor agonists concerning combined endpoints in routine clinical practice: A multicentre retrospective study.

Author: Fadini GP, Sciannameo V, Franzetti I, Bottigliengo D, D'Angelo P, Vinci C, Berchialla P, Arena S, Buzzetti R, and Avogaro A
Subjects: Adult, Aged, Blood Glucose drug effects, Blood Pressure drug effects, Body Weight drug effects, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 physiopathology, Diabetic Angiopathies etiology, Drug Therapy, Combination, Exenatide therapeutic use, Female, Glycated Hemoglobin drug effects, Humans, Liraglutide therapeutic use, Male, Middle Aged, Retrospective Studies, Treatment Outcome, Benzhydryl Compounds therapeutic use, Diabetes Mellitus, Type 2 drug therapy, Diabetic Angiopathies prevention & control, Glucosides therapeutic use, Hypoglycemic Agents therapeutic use, Glucagon-Like Peptide-1 Receptor Agonists
Abstract: Aims: According to cardiovascular outcome trials, some sodium-glucose contransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) are recommended for secondary cardiovascular prevention in type 2 diabetes (T2D). In this real-world study, we compared the simultaneous reductions in HbA1c, body weight and systolic blood pressure after initiation of dapagliflozin or GLP-1RA as second or a more advanced line of therapy., Materials and Methods: DARWIN-T2D was a retrospective multi-centre study conducted at diabetes specialist clinics in Italy that compared T2D patients who initiated dapagliflozin or GLP-1RA (exenatide once weekly or liraglutide). Data were collected at baseline and at the first follow-up visit after 3 to 12 months. The primary endpoint was the proportion of patients achieving a simultaneous reduction in HbA1c, body weight and systolic blood pressure. To reduce confounding, we used multivariable adjustment (MVA) or propensity score matching (PSM)., Results: Totals of 473 patients initiating dapagliflozin and 336 patients initiating GLP-1RA were included. The two groups differed in age, diabetes duration, HbA1c, weight and concomitant medications. The median follow-up was 6 months in both groups. Using MVA or PSM, the primary endpoint was observed in 30% to 32% of patients, with no difference between groups. Simultaneous reduction of HbA1c, BP and SBP by specific threshold, as well as achievement of final goals, did not differ between groups. GLP-1RA reduced HbA1c by 0.3% more than the reduction achieved with dapagliflozin., Conclusion: In routine specialist care, initiation of dapagliflozin can be as effective as initiation of a GLP-1RA for attainment of combined risk factor goals., (© 2019 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.)
Published: 2019
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20. Hypomagnesaemia as a trigger of relapsing non-alcoholic Wernicke encephalopathy: a case report.

Author: Baroncini D, Annovazzi P, Minonzio G, Franzetti I, and Zaffaroni M
Subjects: Adult, Brain diagnostic imaging, Humans, Magnesium Deficiency diet therapy, Male, Wernicke Encephalopathy diet therapy, Magnesium Deficiency complications, Magnesium Deficiency diagnosis, Wernicke Encephalopathy diagnosis, Wernicke Encephalopathy etiology
Published: 2017
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21. Effect of Acarbose on Glycemic Variability in Patients with Poorly Controlled Type 2 Diabetes Mellitus Receiving Stable Background Therapy: A Placebo-Controlled Trial.

Author: Derosa G, Franzetti I, Querci F, D'Angelo A, and Maffioli P
Subjects: Acarbose adverse effects, Adamantane analogs & derivatives, Adamantane therapeutic use, Double-Blind Method, Drug Therapy, Combination, Female, Glycoside Hydrolase Inhibitors therapeutic use, Humans, Hypoglycemic Agents therapeutic use, Male, Metformin therapeutic use, Middle Aged, Monitoring, Ambulatory, Nitriles therapeutic use, Pyrrolidines therapeutic use, Vildagliptin, Acarbose therapeutic use, Blood Glucose drug effects, Diabetes Mellitus, Type 2 blood, Diabetes Mellitus, Type 2 drug therapy
Abstract: Study Objective: To evaluate the effect of acarbose on glycemic control and glycemic variability, using a continuous glucose-monitoring system, in patients with type 2 diabetes mellitus who were not well controlled on metformin and vildagliptin therapy., Design: Multicenter, randomized, double-blind, placebo-controlled study., Setting: Clinical research units at three hospitals in Italy., Patients: Fifty-three patients with type 2 diabetes who were taking stable dosages of metformin 850 mg 3 times/day and vildagliptin 50 mg twice/day for at least 3 months and who were not adequately controlled with these therapies., Intervention: Patients were randomized to either placebo or acarbose 100 mg 3 times/day to be added to their metformin-vildagliptin regimen., Measurements and Main Results: Glycemic excursions were assessed by using a continuous glucose-monitoring system for 1 week. Glycemic control was estimated as the mean blood glucose (MBG) level, the area under the glucose concentration-time curve for a glucose level above 70 mg/dl (AUC above 70) or 180 mg/dl (AUC above 180), and the percentage of time that the glucose level was above 70 mg/dl (T above 70) or 180 mg/dl (T above 180). Intraday glycemic variability was assessed by the standard deviation of the blood glucose level, the mean amplitude of glycemic excursions (MAGE), the M value, and continuous overlapping net glycemic action. Day-to-day glycemic variability was assessed as the mean of daily difference (MODD). The MBG level was ~20 mg/dl lower in the acarbose group than in the placebo group (p<0.05), particularly during the postprandial period. The AUC above 70 did not significantly differ between the two groups, whereas the AUC above 180 was ~40% lower in the acarbose group than in the placebo group during the daytime (p<0.01). The T above 180 was significantly higher in the placebo group than in the acarbose group (31% vs 8%, p<0.01. Moreover, the standard deviation and MAGE values were significantly lower in the acarbose group. The MODD value was not significantly changed in either group, and no significant differences were recorded between groups. All adverse events were mild in both groups, with only a significantly greater frequency of flatulence noted in the acarbose group (5% with acarbose vs 0.5% with placebo, p<0.05)., Conclusion: The addition of acarbose to metformin and vildagliptin background therapy in patients with inadequately controlled type 2 diabetes decreased intraday glycemic variability, especially postprandial variability, but it was not associated with a significant change in interday glycemic variability., (© 2015 Pharmacotherapy Publications, Inc.)
Published: 2015
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22. Comparison of the effects of barnidipine+losartan compared with telmisartan+hydrochlorothiazide on several parameters of insulin sensitivity in patients with hypertension and type 2 diabetes mellitus.

Author: Derosa G, Querci F, Franzetti I, Dario Ragonesi P, D'Angelo A, and Maffioli P
Subjects: Adipokines metabolism, Aged, Diabetes Mellitus, Type 2 complications, Double-Blind Method, Drug Combinations, Female, Glucose Clamp Technique, Humans, Hypertension complications, Male, Middle Aged, Nifedipine therapeutic use, Telmisartan, Angiotensin II Type 1 Receptor Blockers therapeutic use, Antihypertensive Agents therapeutic use, Benzimidazoles therapeutic use, Benzoates therapeutic use, Calcium Channel Blockers therapeutic use, Diabetes Mellitus, Type 2 drug therapy, Diuretics therapeutic use, Hydrochlorothiazide therapeutic use, Hypertension drug therapy, Insulin Resistance, Losartan therapeutic use, Nifedipine analogs & derivatives
Abstract: The aim of this study was to evaluate the effects of barnidipine+losartan compared with telmisartan+hydrochlorothiazide on several parameters of insulin sensitivity in patients with hypertension and type 2 diabetes mellitus. We enrolled 148 normocholesterolemic patients with mild-to-moderate hypertension and type 2 diabetes mellitus. Patients were treated with barnidipine, 20 mg day(-1), in combination with losartan, 100 mg day(-1), or with telmisartan+hydrochlorothiazide, 80/12.5 mg day(-1), for 6 months. We assessed blood pressure (BP) on a monthly basis; additionally, blood samples were collected to assess, at baseline and after 6 months, the following parameters: fasting plasma glucose; glycated hemoglobin; fasting plasma insulin; HOMA index; and some adipocytokines, such as adiponectin (ADN), resistin, leptin, visfatin and vaspin. Patients were also subjected to an euglycemic hyperinsulinemic clamp to assess the M value and glucose infusion rate to ascertain their insulin sensitivity. One hundred and forty-one patients completed the study. The BP was reduced in both groups, although the reduction was greater with barnidipine+losartan (P<0.001 vs. baseline and P<0.01 vs. telmisartan+hydrochlorothiazide). Barnidipine+losartan increased the M value and glucose infusion rate during the euglycemic hyperinsulinemic clamp (P<0.05 vs. baseline and vs. telmisartan+hydrochlorothiazide). With respect to the levels of adipocytokines, ADN was increased (P<0.05), and resistin and leptin were reduced from baseline with barnidipine+losartan (P<0.05 vs. baseline), but they were not reduced with telmisartan+hydrochlorothiazide. Visfatin and vaspin were reduced by barnidipine+losartan compared with baseline (P<0.05). The adipocytokine levels obtained with barnidipine+losartan were significantly better than those obtained with telmisartan+hydrochlorothiazide (P<0.05 for all parameters). In addition to providing a greater BP reduction, barnidipine+losartan improved the insulin sensitivity, as assessed by an euglycemic hyperinsulinemic clamp, and improved some of the adipocytokines related to insulin resistance.
Published: 2015
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23. Barnidipine or Lercanidipine on Echocardiographic Parameters in Hypertensive, Type 2 Diabetics with Left Ventricular Hypertrophy: A Randomized Clinical Trial.

Author: Derosa G, Mugellini A, Querci F, Franzetti I, Pesce RM, D'Angelo A, and Maffioli P
Subjects: Aged, Antihypertensive Agents pharmacology, Calcium Channel Blockers pharmacology, Dihydropyridines pharmacology, Double-Blind Method, Drug Therapy, Combination, Echocardiography, Female, Humans, Hypertension diagnostic imaging, Hypertension drug therapy, Hypertension etiology, Hypertrophy, Left Ventricular diagnostic imaging, Hypertrophy, Left Ventricular etiology, Losartan pharmacology, Male, Middle Aged, Nifedipine pharmacology, Nifedipine therapeutic use, Treatment Outcome, Antihypertensive Agents therapeutic use, Calcium Channel Blockers therapeutic use, Diabetes Mellitus, Type 2 complications, Dihydropyridines therapeutic use, Hypertrophy, Left Ventricular drug therapy, Losartan therapeutic use, Nifedipine analogs & derivatives
Abstract: The aim of this study was to evaluate the effects of lercanidipine or barnidipine on echocardiographic parameters, in hypertensive, type 2 diabetics with left ventricular hypertrophy. One hundred and forty-four patients were randomized to lercanidipine, 20 mg/day, or barnidipine, 20 mg/day, in addition to losartan, 100 mg/day, for 6 months. We evaluated: blood pressure, fasting plasma glucose (FPG), glycated hemoglobin (HbA(1c)), lipid profile, creatinine, estimated glomerular filtration rate (eGFR), sodium, potassium, and acid uric. Echocardiography was performed at baseline and after 6 months. Both lercanidipine and barnidipine decreased blood pressure. Left ventricular mass index was reduced to a greater extent with barnidipine + losartan. Interventricular septal thickness in diastole was reduced by barnidipine + losartan. Posterior wall thickness in diastole was decreased by both treatments, even if barnidipine + losartan were more effective. Ratio of peak early diastolic filling velocity to peak filling velocity at atrial contraction was increased by barnidipine + losartan, but not by lercanidipine + losartan. Finally, isovolumetric relaxation and time and left atrial volume index were reduced by barnidipine + losartan, while lercanidipine + losartan did not affect them. In conclusion, barnidipine + losartan provided a greater improvement of echocardiographic parameters compared to lercanidipine + losartan.
Published: 2015
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24. Glucose-lowering effect and glycaemic variability of insulin glargine, insulin detemir and insulin lispro protamine in people with type 1 diabetes.

Author: Derosa G, Franzetti I, Querci F, Romano D, D'Angelo A, and Maffioli P
Subjects: Adult, Analysis of Variance, Area Under Curve, Blood Glucose Self-Monitoring statistics & numerical data, Diabetes Mellitus, Type 1 blood, Diabetes Mellitus, Type 1 complications, Double-Blind Method, Female, Humans, Hypoglycemia epidemiology, Hypoglycemia etiology, Male, Young Adult, Blood Glucose analysis, Diabetes Mellitus, Type 1 drug therapy, Hypoglycemic Agents therapeutic use, Insulin Detemir therapeutic use, Insulin Glargine therapeutic use, Insulin Lispro therapeutic use
Abstract: Aim: To compare, using a continuous glucose monitoring (CGM) system, the effect on glycaemic variability of insulin glargine, detemir and lispro protamine., Methods: A total of 49 white people with type 1 diabetes, not well controlled by three times daily insulin lispro, taken for at least 2 months before study and on a stable dose, were enrolled. The study participants were randomized to add insulin glargine, detemir or lispro protamine, once daily, in the evening. We used a CGM system, the iPro Digital Recorder (Medtronic MiniMed, Northridge, CA, USA) for 1 week. Glycaemic control was assessed according to mean blood glucose values, the area under the glucose curve above 3.9 mmol/l (AUC(>3.9)) or above 10.0 mmol/l (AUC(>10.0)), and the percentage of time spent with glucose values >3.9 or >10.0 mmol/l. Intraday glycaemic variability was assessed using standard deviation (s.d.) values, the mean amplitude of glycaemic excursions and continuous overlapping of net glycaemic action. Day-to-day glycaemic variability was assessed using the mean of daily differences., Results: The s.d. was found to be significantly lower with insulin lispro protamine and glargine compared with insulin detemir. AUC(>3.9) was higher and AUC(>10.0) was lower with insulin lispro protamine and glargine compared with detemir. The mean amplitude of glycaemic excursions and continuous overlapping net glycaemic action values were lower with insulin lispro protamine and glargine compared with detemir. In addition, the mean of daily differences was significantly lower with insulin lispro protamine and glargine compared with detemir. Fewer hypoglycaemic events were recorded during the night-time with insulin lispro protamine compared with glargine and detemir., Conclusions: The results suggest that insulin lispro protamine and glargine are more effective than detemir in reducing glycaemic variability and improving glycaemic control in people with type 1 diabetes. Insulin lispro protamine seems to lead to fewer hypoglycaemic events than other insulin regimens., (© 2015 John Wiley & Sons Ltd.)
Published: 2015
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25. Effects of a combination of sitagliptin plus metformin vs metformin monotherapy on glycemic control, β-cell function and insulin resistance in type 2 diabetic patients.

Author: Derosa G, Carbone A, Franzetti I, Querci F, Fogari E, Bianchi L, Bonaventura A, Romano D, Cicero AF, and Maffioli P
Subjects: Blood Glucose metabolism, C-Peptide blood, C-Reactive Protein metabolism, Diabetes Mellitus, Type 2 blood, Double-Blind Method, Drug Therapy, Combination, Exercise, Fasting blood, Female, Glucagon blood, Glucose Clamp Technique, Glycated Hemoglobin metabolism, Humans, Hypoglycemic Agents pharmacology, Italy, Male, Metformin pharmacology, Middle Aged, Pyrazines pharmacology, Sitagliptin Phosphate, Treatment Outcome, Triazoles pharmacology, Diabetes Mellitus, Type 2 drug therapy, Hypoglycemic Agents administration & dosage, Insulin Resistance, Insulin-Secreting Cells drug effects, Insulin-Secreting Cells metabolism, Metformin administration & dosage, Pyrazines administration & dosage, Triazoles administration & dosage
Abstract: Aims: To evaluate the impact on glycemic control, insulin resistance, and insulin secretion of sitagliptin+metformin compared to metformin in type 2 diabetic patients., Methods: Patients were instructed to take metformin for 8 ± 2 months, then they were randomly assigned to sitaglipin 100 mg or placebo for 12 months. We evaluated at 3, 6, 9, and 12 months: body mass index (BMI), glycemic control, fasting plasma insulin (FPI), HOMA-IR, HOMA-β, fasting plasma proinsulin (FPPr), proinsulin/fasting plasma insulin ratio (Pr/FPI ratio), C-peptide, glucagon, adiponectin (ADN), and high sensitivity-C reactive protein (Hs-CRP). Before, and after 12 months since the addition of sitagliptin, patients underwent a combined euglycemic hyperinsulinemic and hyperglycemic clamp, with subsequent arginine stimulation., Results: Both treatments similarly decreased body weight, and BMI; on the other hand, they both improved glycemic control, glucagon and HOMA-IR, but sitagliptin+metformin were more effective in reducing these parameters. Sitagliptin+metformin, but not placebo+metformin, decreased FPPr, FPPR/FPI ratio, and increased C-peptide values, even if no differences between the groups were recorded. Sitaglitin+metformin gave also a greater increase of HOMA-β, M value, C-peptide response to arginine and disposition index compared to placebo+metformin group., Conclusions: Other than improving glycemic control, sitagliptin+metformin also improved β-cell function better than metformin alone., (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)
Published: 2012
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26. Outcome of pregnancy in type 1 diabetic patients treated with insulin lispro or regular insulin: an Italian experience.

Author: Lapolla A, Dalfrà MG, Spezia R, Anichini R, Bonomo M, Bruttomesso D, Di Cianni G, Franzetti I, Galluzzo A, Mello G, Menato G, Napoli A, Noacco G, Parretti E, Santini C, Scaldaferri E, Scaldaferri L, Songini M, Tonutti L, Torlone E, Gentilella R, Rossi A, and Valle D
Subjects: Birth Weight, Chromatography, High Pressure Liquid, Diabetes Mellitus, Type 1 complications, Female, Glycated Hemoglobin metabolism, Humans, Infant, Newborn, Infant, Small for Gestational Age, Insulin Lispro, Italy, Pregnancy, Retrospective Studies, Diabetes Mellitus, Type 1 drug therapy, Hypoglycemic Agents therapeutic use, Insulin analogs & derivatives, Insulin therapeutic use, Pregnancy Complications drug therapy
Abstract: Some studies have shown that fetal outcome observed in patients using insulin lispro is much the same as in pregnant women using regular insulin. This study aims to analyze the Italian data emerging from a multinational, multicenter, retrospective study on mothers with type 1 diabetes mellitus before pregnancy, comparing those treated with insulin lispro for at least 3 months before and 3 months after conception with those treated with regular insulin. The data collected on pregnant women with diabetes attending 15 Italian centers from 1998 to 2001 included: HbA1c at conception and during the first and third trimesters, frequency of severe hypoglycemic episodes, spontaneous abortions, mode and time of delivery, fetal malformations and mortality. Seventy-two diabetic pregnancies treated with lispro and 298 treated with regular insulin were analyzed, revealing a trend towards fewer hypoglycemic episodes in the former, who also had a significantly greater reduction in HbA1c during the first trimester. The rate of congenital malformations was similar in the offspring of the two groups of women treated with insulin lispro or regular insulin. These findings suggest that insulin lispro could be useful for the treatment of hyperglycemia in type 1 diabetic pregnant women.
Published: 2008
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27. Simvastatin treatment modifies polymorphonuclear leukocyte function in high-risk individuals: a longitudinal study.

Author: Guasti L, Marino F, Cosentino M, Cimpanelli M, Maio RC, Klersy C, Crespi C, Restelli D, Simoni C, Franzetti I, Gaudio G, Marnini P, Grandi AM, Lecchini S, and Venco A
Subjects: Female, Humans, Longitudinal Studies, Male, Middle Aged, Risk Factors, Vascular Diseases prevention & control, Hydroxymethylglutaryl-CoA Reductase Inhibitors pharmacology, Neutrophils drug effects, Neutrophils physiology, Simvastatin pharmacology
Abstract: Background: Although extensive experimental evidence supports a primary role of polymorphonuclear leukocytes (PMNs) in atherosclerosis, few data exist concerning the functional properties of these cells and their pharmacological modulation in high-risk individuals., Objective: The production of the proinflammatory chemokine interleukin-8 (IL-8), migration and chemotaxis, and reactive oxygen species (ROS) generation were investigated in a longitudinal study in PMNs obtained from high-risk individuals during statin treatment. As a secondary endpoint we compared PMN function of high-risk patients with that of controls., Methods and Results: PMNs were isolated from 21 high-risk individuals before treatment and 3 and 30 days after the beginning of simvastatin treatment, and from healthy controls. During treatment a significant reduction was observed both in resting (P = 0.009) and N-formyl-Met-Leu-Phe (fMLP)-stimulated (P = 0.008) IL-8 production, and in the chemotactic index (P = 0.038), whereas ROS generation did not significantly change. In comparison with cells from controls, PMNs obtained from patients before starting simvastatin treatment showed higher resting and fMLP-stimulated IL-8 release (P = 0.007 and P = 0.002, respectively) and ROS generation (resting, P = 0.009; and fMLP-stimulated, P = 0.046), whereas migration and the chemotactic index did not significantly differ., Conclusions: An activation of neutrophils is present in high-risk individuals, shown by the enhanced production of IL-8, and increased ROS generation. The 4-week statin treatment is able to reduce the cell capability to produce IL-8, and to decrease chemotaxis, thus affecting the proinflammatory properties of PMNs.
Published: 2006
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28. Metabolic variations with oral antidiabetic drugs in patients with Type 2 diabetes: comparison between glimepiride and metformin.

Author: Derosa G, Franzetti I, Gadaleta G, Ciccarelli L, and Fogari R
Subjects: Aged, Blood Glucose analysis, Fasting, Female, Food, Glycated Hemoglobin analysis, Homocysteine blood, Humans, Hypoglycemic Agents administration & dosage, Lipoprotein(a) blood, Male, Metformin administration & dosage, Middle Aged, Plasminogen Activator Inhibitor 1 blood, Sulfonylurea Compounds administration & dosage, Diabetes Mellitus, Type 2 blood, Diabetes Mellitus, Type 2 drug therapy, Hypoglycemic Agents therapeutic use, Metformin therapeutic use, Sulfonylurea Compounds therapeutic use
Abstract: Patients with Type 2 diabetes (T2DM) are at high risk of morbidity and mortality from cardiovascular complications, and hypoglycaemia increases this risk. Furthermore, other metabolic parameters exacerbate cardiovascular risk in these patients. The aim of the study was to compare the metabolic effects of glimepiride and metformin in patients with T2DM. We evaluated 164 patients with T2DM (80 males, 84 females) in a multicentre, randomised, controlled, open, parallel group study comparing glimepiride with metformin. Eighty-one patients (aged 56+/-10 yr) received glimepiride (3+/-1 mg/d); 83 patients (aged 58+/-9 yr) received metformin (2500+/-500 mg/d). Patients had been diagnosed for < or = 6 months; they were non-smokers; had no hypertension or coronary heart disease; were not taking hypolipidaemic drugs, diuretics, beta-blockers or thyroxin; and had normal renal function. Metabolic parameters were measured after 6 and 12 months of treatment. Glimepiride significantly lowered lipoprotein(a) [Lp(a)] and homocysteine levels (HCT) at 6 and 12 months. Both glimepiride and metformin lowered plasminogen activator inhibitor Type 1 (PAI-1) at 12 months and significantly improved levels of glycosylated haemoglobin, fasting plasma glucose and post-prandial plasma glucose after 6 and 12 months. Metformin significantly lowered fasting plasma insulin and postprandial plasma insulin. Glimepiride and metformin also reduced levels of other metabolic parameters in patients with T2DM. In particular, glimepiride significantly reduced HCT, Lp(a), and PAI-1 levels, important metabolic risk factors for atherosclerotic vascular disease. These reductions may be owing to improved glucose metabolism, but it cannot be excluded that these drugs have a direct effect on additional metabolic parameters.
Published: 2004

29. Possible synergistic effect of metformin and enalapril on the development of hyperkaliemic lactic acidosis.

Author: Franzetti I, Paolo D, Marco G, Emanuela M, Elisabetta Z, and Renato U
Subjects: Acidosis blood, Aged, Antihypertensive Agents therapeutic use, Chlorides blood, Diabetes Mellitus, Type 2 drug therapy, Drug Synergism, Drug Therapy, Combination, Enalapril therapeutic use, Female, Humans, Hypertension drug therapy, Hypoglycemic Agents therapeutic use, Lactic Acid blood, Metformin therapeutic use, Acidosis chemically induced, Antihypertensive Agents adverse effects, Enalapril adverse effects, Hypoglycemic Agents adverse effects, Metformin adverse effects
Abstract: A 71 year old hypertensive, non insulin-dependent diabetic patient with moderate renal insufficiency taking 500 mg/d of metformin and 5 mg/d of enalapril, developed metabolic acidosis characterized by fairly elevated anion gap, hyperchloremia, severe hyperkaliemia, normal plasma level of 3-hydroxybutyric acid, absence of ketonuria and high plasma level of lactic acid. This biochemical feature allowed us to ascribe the pathogenesis of metabolic acidosis, both to the increased plasma level of lactic acid and to the type IV renal tubular acidosis syndrome, the precipitating factor being an infection of urinary tract (as we assumed on the basis of the urine culture). The patient was dehydrated and lethargic; the ECG revealed the presence of nonparoxysmal junctional tachycardia. The clinical evolution was favorable under the treatment with an infusion of isotonic saline solutions, mild alkalinizing solutions, low-dose regular insulin and antibiotics. It is likely that metformin and enalapril, regularly taken by this nephropathic patient, could have played an iatrogenic role, even if the doses were low. This case highlights the importance of complying with the contraindications of these drugs, to avoid the rare but reported life-threatening complications of metformin administration.
Published: 1997
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30. [Lactic acidosis and severe hyperkalemia in a diabetic patient treated with metformin and enalapril: influence of acute renal disease and drugs].

Author: Franzetti I, Donnini P, Gaiazzi M, Mazzola E, Zibetti E, and Uccella R
Subjects: Acidosis, Lactic therapy, Acute Disease, Aged, Diabetes Mellitus, Type 2 drug therapy, Female, Follow-Up Studies, Humans, Hyperkalemia therapy, Hypertension drug therapy, Iatrogenic Disease, Injections, Subcutaneous, Insulin administration & dosage, Time Factors, Acidosis, Lactic chemically induced, Acidosis, Renal Tubular complications, Diabetes Mellitus, Type 2 complications, Enalapril adverse effects, Hyperkalemia chemically induced, Metformin adverse effects
Abstract: A 71 year old hypertensive and non insulin-dependent diabetic patients with moderate renal insufficiency taking 500 mg/d of metformin and 5 mg/d of enalapril, developed metabolic acidosis characterized by fairly elevated anion gap, hyperchloremia, severe hyperkalemia, normal plasma level of beta-hydroxybutyric acid, absence of ketonuria and high plasma level of lactic acid. This biochemical feature allowed us to ascribe the pathogenesis of metabolic acidosis both to the increased plasma level of lactic acid and to the type IV renal tubular acidosis syndrome, the precipitating factor being an infection of urinary tract (as we assumed on the basis of the urine culture). The patient was dehydrated and lethargic; the ECG revealed the presence of nonparoxysmal junctional tachycardia. The clinical evolution was favorable thanks to the treatment with the infusion of isotonic saline solutions, mild alkalinizing solutions, low-dose regular insulin and antibiotics. It is likely that metformin and enalapril, regularly assumed by the patient, could have played a iatrogenic role even if they were taken in low dosages. This event points out the importance of complying with the indications and especially the contraindications of these drugs, to avoid life threatening complications as that one occurred in this case.
Published: 1995

31. Pheochromocytoma.

Author: Uccella R, Franzetti I, Donnini P, and Gaiazzi M
Subjects: Adrenal Gland Neoplasms complications, Adrenal Gland Neoplasms epidemiology, Adrenal Gland Neoplasms pathology, Aged, Aged, 80 and over, Female, Glucagon, Humans, Italy epidemiology, Pheochromocytoma complications, Pheochromocytoma epidemiology, Pheochromocytoma pathology, Prevalence, Adrenal Gland Neoplasms diagnosis, Diabetes Mellitus, Type 2 complications, Pheochromocytoma diagnosis
Published: 1993
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32. Serum lipid pattern as severity indicator of angiographically assessed coronary artery disease.

Author: Uccella R, Donnini P, Franzetti I, and Gaiazzi M
Subjects: Adult, Analysis of Variance, Apolipoprotein A-I analysis, Apolipoprotein B-100, Apolipoproteins B analysis, Biomarkers blood, Cholesterol blood, Cholesterol, HDL blood, Cholesterol, LDL blood, Coronary Angiography, Coronary Disease diagnostic imaging, Female, Humans, Lipids blood, Male, Middle Aged, Regression Analysis, Triglycerides blood, Apolipoproteins analysis, Coronary Disease blood, Coronary Disease diagnosis
Abstract: In this study we compared the relative utility of plasma lipid and apolipoprotein pattern as predictor of extent of Coronary Artery Disease as angiographically established. The lipid and apolipoprotein values were plotted in multiple stepwise analysis against coronary score determined as follows: at least 1 coronary artery system (left, anterior, descendent, circumflex, right) with a >/= 25% stenosis 1 point, number of involved vessel 1, 2, 3, .... adjunctive points; sequential lesions +1 point; < = %50% stenosis +1 point; 75-95 % +2 points; > 95% +3 points. The statistical analysis demonstrate a strong influence on extent of disease by total-cholesterol, % HDL-cholesterol on total cholesterol and by the difference between LDL and HDL-cholesterol. We conclude that, in predicting the extension of CAD, is important to know how total cholesterol is distributed in plasma apolipoprotein system.
Published: 1993

33. Epidural spinal electrostimulatory system (ESES) in the management of diabetic foot and peripheral arteriopathies.

Author: Franzetti I, De Nale A, Bossi A, Greco M, Morricone L, Ruggerini M, Meazza D, Sciolla A, Caviezel F, and Oriani G
Subjects: Aged, Epidural Space, Female, Follow-Up Studies, Humans, Male, Middle Aged, Arteriosclerosis therapy, Diabetic Angiopathies therapy, Electric Stimulation Therapy, Foot Diseases therapy, Intermittent Claudication therapy, Palliative Care methods, Spinal Cord physiology
Abstract: Epidural spinal electrostimulatory system (ESES) or dorsal column stimulation (DCS) may be used for the treatment of peripheral vascular diseases of the lower extremities. ESES has been used in our metabolic and surgical department as a way to ameliorate inadequate blood supply in patients suffering from diabetic foot (seven patients), painful chronic arterial narrowing, or inoperable occlusions (25 patients). The continuous stimulation by an implantable apparatus (Medtronic model Itrel, Medtronic, Inc., Minneapolis, MN, USA) led to a reduction or disappearance of pain, an improvement in plethysmographic curves, functional performance, and trophic lesions in about 75% of the patients. The system is safe and well-tolerated by patients.
Published: 1989
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33 results on '"I. Franzetti"'

1. Quality of Life, Wishes, and Needs in Women with Gestational Diabetes: Italian DAWN Pregnancy Study

2. Rationale and design of the DARWIN-T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes)

3. Author response for 'Similar effectiveness of dapagliflozin versus GLP‐1 receptor agonists on combined endpoints in routine clinical practice. A multicenter retrospective study'

4. Masked Hypertension in Type 2 Diabetes MellitusRelationship With Left-Ventricular Structure and Function

5. Effect of Glycemic Control on Left Ventricular Diastolic Function in Type 1 Diabetes Mellitus

6. QUALITY OF LIFE AND TREATMENT SATISFACTION IN PATIENTS WITH TYPE 1 DIABETES: A COMPARISON BETWEEN CONTINUOUS SUBCUTANEOUS INSULIN INJECTION AND MULTIPLE DAILY INJECTIONS

7. Quality of Life, Wishes, and Needs in Women with Gestational Diabetes: Italian DAWN Pregnancy Study

8. Quality of life and treatment satisfaction in adults with Type 1 diabetes: a comparison between continuous subcutaneous insulin infusion and multiple daily injections

9. Outcome of pregnancy in type 1 diabetic patients treated with insulin lispro or regular insulin: an Italian experience

10. Simvastatin treatment modifies polymorphonuclear leukocyte function in high-risk individuals: a longitudinal study

11. 40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004

12. GLYCEMIC CONTROL IN TYPE 2 DIABETES MELLITUS: RELATIONSHIP WITH LEFT VENTRICULAR DIASTOLIC DYSFUNCTION AND MATRIX METALLOPROTEINASES

13. [Lactic acidosis and severe hyperkalemia in a diabetic patient treated with metformin and enalapril: influence of acute renal disease and drugs]

14. Serum lipid pattern as severity indicator of angiographically assessed coronary artery disease

15. Effects of simvastatin on polymorphonuclear leukocyte function in high-risk patients

16. Treatment with simvastatin reduces interleukin-8 production by polymorphonuclear leukocytes in high-risk patients

17. Mental Arithmetic Stress as a Test for Evaluation of Diabetic Sympathetic Autonomic Neuropathy

18. Dapagliflozin acutely improves kidney function in type 2 diabetes mellitus. The PRECARE study.

19. Similar effectiveness of dapagliflozin and GLP-1 receptor agonists concerning combined endpoints in routine clinical practice: A multicentre retrospective study.

20. Hypomagnesaemia as a trigger of relapsing non-alcoholic Wernicke encephalopathy: a case report.

21. Effect of Acarbose on Glycemic Variability in Patients with Poorly Controlled Type 2 Diabetes Mellitus Receiving Stable Background Therapy: A Placebo-Controlled Trial.

22. Comparison of the effects of barnidipine+losartan compared with telmisartan+hydrochlorothiazide on several parameters of insulin sensitivity in patients with hypertension and type 2 diabetes mellitus.

23. Barnidipine or Lercanidipine on Echocardiographic Parameters in Hypertensive, Type 2 Diabetics with Left Ventricular Hypertrophy: A Randomized Clinical Trial.

24. Glucose-lowering effect and glycaemic variability of insulin glargine, insulin detemir and insulin lispro protamine in people with type 1 diabetes.

25. Effects of a combination of sitagliptin plus metformin vs metformin monotherapy on glycemic control, β-cell function and insulin resistance in type 2 diabetic patients.

26. Outcome of pregnancy in type 1 diabetic patients treated with insulin lispro or regular insulin: an Italian experience.

27. Simvastatin treatment modifies polymorphonuclear leukocyte function in high-risk individuals: a longitudinal study.

28. Metabolic variations with oral antidiabetic drugs in patients with Type 2 diabetes: comparison between glimepiride and metformin.

29. Possible synergistic effect of metformin and enalapril on the development of hyperkaliemic lactic acidosis.

30. [Lactic acidosis and severe hyperkalemia in a diabetic patient treated with metformin and enalapril: influence of acute renal disease and drugs].

31. Pheochromocytoma.

32. Serum lipid pattern as severity indicator of angiographically assessed coronary artery disease.

33. Epidural spinal electrostimulatory system (ESES) in the management of diabetic foot and peripheral arteriopathies.

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