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6 results on '"I. Bexiga"'

1. Hemodiálise crónica com acetato em doentes com idade superior a 70 anos.

Author

P L Neves, I Bexiga, I Pinto, and J P Amorim

Subjects
Medicine, Medicine (General), R5-920
Abstract

During the last years there has a significant increase of elderly patients included in chronic dialysis programs. No agreement has been reached about the preferable treatment modality. In this study we analyse our experience in the management of patients over 70 years of age undergoing chronic acetate hemodialysis (HDCA). Sixty four of those patients have initiated HDCA between May 1982 and December 1990 (Mean age 75.9 +/- 4.8). The etiology of renal disease was unknown in a significant number of cases. Morbility was largely due to vascular disease (both cardiac and cerebral). Main causes of death were also vascular disease and infections. Actuarial survival was 79.6% at 12 months and 46.3% after 5 years. Although HDCA is associated with a greater morbility it is the most widely used modality of treatment for chronic renal failure in Portugal and in our experience, it is an acceptable method for elderly patients.

Published
1992
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2. Cardiovascular complications in CKD 5D

Author

M. Fusaro, M. Noale, G. Tripepi, A. D'angelo, D. Miozzo, M. Gallieni, P.-V. Study Group, M. Tsamelesvili, C. Dimitriadis, A. Papagianni, C. Raidis, G. Efstratiadis, D. Memmos, R. Mutluay, C. Konca Degertekin, U. Derici, S. M. Deger, F. Akkiyal, S. Gultekin, S. Gonen, G. Tacoy, T. Arinsoy, S. Sindel, C. Sanchez-Perales, E. Vazquez, E. Merino, P. Perez Del Barrio, F. J. Borrego, M. J. Borrego, A. Liebana, M. Krzanowski, K. Janda, P. Dumnicka, A. Krasniak, W. Sulowicz, Y.-O. Kim, S.-A. Yoon, Y.-S. Yun, H.-C. Song, B.-S. Kim, M. A. Cheong, A. Pasch, S. Farese, J. Floege, W. Jahnen-Dechent, T. Ohtake, R. Furuya, M. Iwagami, D. Tsutsumi, Y. Mochida, K. Ishioka, M. Oka, K. Maesato, H. Moriya, S. Hidaka, S. Kobayashi, A. Guedes, A. Malho Guedes, A. Pinho, A. Fragoso, A. Cruz, P. Mendes, E. Morgado, I. Bexiga, A. P. Silva, P. Neves, N. Oyake, K. Suzuki, S. Itoh, S. Yano, K. Turkmen, H. Kayikcioglu, O. Ozbek, M. Saglam, A. Toker, H. Z. Tonbul, S. Gelev, L. Trajceska, E. Srbinovska, S. Pavleska, V. Amitov, G. Selim, P. Dzekova, A. Sikole, H. Bouarich, S. Lopez, C. Alvarez, I. Arribas, P. DE Sequera, D. Rodriguez, S. Tanaka, T. Kanemitsu, M. Sugahara, M. Kobayashi, L. Uchida, Y. Ishimoto, N. Kotera, S. Tanimoto, K. Tanabe, K. Hara, T. Sugimoto, N. Mise, B. Goldstein, M. Turakhia, C. Arce, W. Winkelmayer, B. E.-D. Zayed, K. Said, M. Nishimura, Y. Okamoto, T. Tokoro, M. Nishida, T. Hashimoto, N. Iwamoto, H. Takahashi, T. Ono, N. Sato, J. Raimann, L. A. Usvyat, J. Sands, N. W. Levin, P. Kotanko, M. Iwasaki, N. Joki, Y. Tanaka, N. Ikeda, T. Hayashi, S. Kubo, T.-A. Imamura, Y. Takahashi, K. Hirahata, Y. Imamura, H. Hase, K. Claes, B. Meijers, B. Bammens, D. Kuypers, M. Naesens, Y. Vanrenterghem, P. Evenepoel, G. Boscutti, L. Calabresi, M. Bosco, S. Simonelli, E. Boer, C. Vitali, M. Martone, P. L. Mattei, G. Franceschini, E. Baligh, E. El-Shafey, A. Ezaat, A. Zawada, K. Rogacev, B. Hummel, O. Grun, A. Friedrich, B. Rotter, P. Winter, J. Geisel, D. Fliser, G. H. Heine, J.-I. Makino, K.-S. Makino, T. Ito, S. Genovesi, A. Santoro, P. Fabbrini, E. Rossi, D. Pogliani, A. Stella, G. Bonforte, G. Remuzzi, S. Bertoli, C. Pozzi, S. Pasquali, L. Cagnoli, F. Conte, I. Buzadzic, J. Tosic, N. Dimkovic, Z. Djuric, J. Popovic, I. Pejin Grubisa, N. Barjaktarevic, A. DI Napoli, D. DI Lallo, M. F. Salvatori, F. Franco, S. Chicca, G. Guasticchi, M. Onofriescu, S. Hogas, V. Luminita, A. Mugurel, V. Gabriel, F. Laura, M. Irina, C. Adrian, E. Bosch, E. Baamonde, C. Culebras, G. Perez, B. El Hayek, J. I. Ramirez, A. Ramirez, C. Garcia, M. Lago, A. Toledo, M. D. Checa, T. Taira, T. Hirano, K. Nohtomi, T. Hyodo, T. Chiba, A. Saito, Y. K. Kim, E. J. Choi, C. W. Yang, Y.-S. Kim, P. S. Lim, W. Ming Ying, J. Ya-Chung, I. Zaripova, I. Kayukov, A. Essaian, A. Nimgirova, H. Young, M. Dungey, E. L. Watson, R. Baines, J. O. Burton, A. C. Smith, K. Yamazaki, M. Bossola, L. Colacicco, D. Scribano, C. Vulpio, L. Tazza, T. Okada, N. Okada, I. Michibata, T. Yura, N. Montero, M. Soler, M. Pascual, C. Barrios, E. Marquez, E. Rodriguez, M. A. Orfila, H. Cao, E. Arcos, J. Comas, J. Pascual, M. Ferrario, F. Garzotto, T. Sironi, S. Monacizzo, F. Basso, D. N. Cruz, U. Moissl, C. Tetta, M. G. Signorini, S. Cerutti, C. Ronco, I. Mostovaya, M. Grooteman, M. Van den Dorpel, L. Penne, N. Van der Weerd, A. Mazairac, C. Den Hoedt, R. Levesque, M. Nube, P. Ter Wee, M. Bots, P. Blankestijn, J. Liu, K. L. MA, X. Zhang, B. C. Liu, I.-D. Vladu, R. Mustafa, D. Cana-Ruiu, C. Vaduva, C. Grauntanu, E. Mota, R. Singh, N. Abbasian, C. Stover, N. Brunskill, J. Burton, K. Herbert, A. Bevington, M. Wu, R.-N. Tang, M. Gao, H. Liu, L. Chen, L.-L. LV, B.-C. Liu, M. Nikodimopoulou, S. Liakos, S. Kapoulas, C. Karvounis, D. Fedak, M. Kuzniewski, D. Paulina, B. Kusnierz-Cabala, M. Kapusta, B. Solnica, A. Junque, E. S. Vicent, L. Moreno, M. Fulquet, V. Duarte, A. Saurina, M. Pou, J. Macias, M. Lavado, M. Ramirez de Arellano, M. Ryuzaki, H. Nakamoto, S. Kinoshita, E. Kobayashi, C. Takimoto, T. Shishido, G. Enia, C. Torino, R. Tripepi, V. Panuccio, M. Postorino, A. Clementi, M. Garozzo, G. Bonanno, R. Boito, G. Natale, T. Cicchetti, A. Chippari, D. Logozzo, G. Alati, S. Cassani, A. Sellaro, C. Zoccali, B. Quiroga, E. Verde, S. Abad, A. Vega, M. Goicoechea, J. Reque, J. M. Lopez-Gomez, J. Luno, C. Cabre Menendez, V. Moles, J. P. Vives, D. Villa, J. Vinas, T. Compte, M. Arruche, C. Diaz, J. Soler, J. Aguilera, A. Martinez Vea, A. De Mauri, P. David, M. M. Conte, D. Chiarinotti, C. E. Ruva, M. De Leo, A.-S. Bargnoux, M. Morena, I. Jaussent, L. Chalabi, P. Bories, J.-J. Dion, P. Henri, M. Delage, A.-M. Dupuy, S. Badiou, B. Canaud, J.-P. Cristol, E. Sironi, F. Pieruzzi, E. Galbiati, M. R. Vigano, S. Anpalakhan, S. Rocha, N. Chitalia, R. Sharma, J. C. Kaski, J. Chambers, D. Goldsmith, D. Banerjee, V. Cernaro, A. Lacquaniti, R. Lupica, S. Lucisano, M. R. Fazio, V. Donato, M. Buemi, I. Segalen, U. Vinsonneau, T. Tanquerel, G. Quiniou, Y. Le Meur, E. Seibert, M. Girndt, K. Zohles, C. Ulrich, A. Kluttig, S. Nuding, C. Swenne, J. Kors, K. Werdan, R. Fiedler, N. C. Van der Weerd, M. P. Grooteman, M. A. Van den Dorpel, M. J. Nube, J. Wetzels, D. W. Swinkels, P. M. Ter Wee, A. Khandekar, J. Khandge, J. E. Lee, S. J. Moon, K. H. Choi, H. Y. Lee, B. S. Kim, E. Tuaillon, A. Rodriguez, L. Chenine, J.-P. Vendrell, Y.-M. Sue, C.-H. Tang, Y.-C. Chen, P. Segura, M. J. Garcia Cortes, J. M. Gil, M. M. Biechy, D. Poulikakos, A. Shah, M. Persson, P. Dattolo, M. Amidone, S. Michelassi, L. Moriconi, G. Betti, P. Conti, A. Rosati, A. Mannarino, V. Panichi, F. Pizzarelli, K. Klejna, B. Naumnik, E. Koc-Zorawska, M. Mysliwiec, S. Dimitrie, H. Simona, O. Mihaela, O. Gabriela, S. Radu, P. Octavian, H. Akdam, H. Akar, Y. Yenicerioglu, O. Kucuk, I. Kurt Omurlu, S. Thambiah, R. Roplekar, P. Manghat, I. Fogelman, W. Fraser, G. Hampson, E. Likaj, G. Caco, S. Seferi, M. Rroji, M. Barbullushi, N. Thereska, A. Serban, V. Carmen, S. Cristian, L. Silvia, and A. Covic

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, medicine, Intensive care medicine, business
Published
2012
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3. Elderly patients on chronic hemodialysis with hyperparathyroidism: increase of hemoglobin level after intravenous calcitriol.

Author

Neves PL, Triviño J, Casaubon F, Santos V, Mendes P, Romão P, Bexiga I, and Bernardo I

Subjects
Aged, Epoetin Alfa, Erythropoietin administration & dosage, Female, Follow-Up Studies, Hematinics administration & dosage, Humans, Hyperparathyroidism, Secondary etiology, Infusions, Intravenous, Kidney Failure, Chronic complications, Kidney Failure, Chronic therapy, Male, Recombinant Proteins, Calcitriol administration & dosage, Calcium Channel Agonists administration & dosage, Hemoglobins metabolism, Hyperparathyroidism, Secondary blood, Hyperparathyroidism, Secondary therapy, Kidney Failure, Chronic blood, Renal Dialysis
Abstract

In patients on chronic hemodialysis (CHD), hyperparathyroidism (HPTH) is associated with anemia and resistance to erythropoietin (EPO). In the last few years, calcitriol intravenously (IV) has been used with success in the treatment of the HPTH, secondary to chronic renal failure. However, the effects of calcitriol on the hematological parameters of these patients have never been well evaluated. This study included 11 elderly CHD patients (f = 6, m = 5; mean age = 73.6 years, mean time on CHD = 42.8 months) with HPTH under EPO therapy (IV). They were treated for 12 months with calcitriol IV (mean dose = 2.33 mcg/pt/week). Patients with iron deficiency anemia (ferritin < 200 ng/ml) were excluded. The patients were compared before and after 12 months of calcitriol treatment, with respect to several laboratory parameters and with respect to EPO dose. A paired t-test was used. After treatment, we found a decrease of PTH (634 vs. 418 pg/ml, P = 0.029); the serum calcium increased (8.8 vs. 9.9 mg/dl, P = 0.002); no differences were noted in the plasma levels of alkaline phosphatase, phosphorous, BUN, creatinine, Na and K. Mean levels of Hb (10.2 vs. 11.4 g/dl, P = 0.004) and the Hct (30 vs. 34.3, P = 0.004) increased after 12 months of calcitriol; the levels of serum iron (70 vs. 78 microg/dl, P = ns) and ferritin (531 vs. 785 ng/ml, P = ns) and the EPO dose (105 vs. 100 U/kg/week, P = ns) were similar before and after treatment. Our data show that the treatment of HPTH in CHD elderly patients with calcitriol can increase Hb level without increasing EPO dose.

Published
2006
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4. Elderly patients on chronic hemodialysis: effect of the secondary hyperparathyroidism on the hemoglobin level.

Author

Neves PL, Triviño J, Casaubon F, Romão P, Mendes P, Bexiga I, Pinto I, Santos V, and Bernardo I

Subjects
Age Factors, Aged, Aged, 80 and over, Female, Humans, Male, Hemoglobins analysis, Hyperparathyroidism, Secondary blood, Renal Dialysis
Abstract

In patients on chronic hemodialysis (CHD) hyperparathyroidism (HPTH) is associated with anemia and resistance to erythropoietin (EPO). This study included 86 CHD elderly pts (mean age 74.8 y, mean time on CHD = 50.5 mos); they were divided into two groups: I (n = 31) - PTH > 250 pg/mL and II (n = 55) - PTH < 250 pg/mL. All these patients had been on CHD for > 6 mos. No differences were found between groups in respect to age, sex distribution and time on CHD. The levels of creatinine, BUN, Ca, Al, Fe, albumin and ferritin were similar. Group I had a higher P level (5.4 vs 4.3 mg/dL, p = 0.001) and Ca x P (53.5 vs 43.7, p = 0.009). Also the Hct (31 vs 33.5%, p = 0.008) and the Hb (10.4 vs 11.2 g/dL, p = 0.009) values were lower in Group I. The EPO dose (88 vs 85 U/kg/week, p = ns) was similar in the two groups. Our data showed that elderly patients with HPTH have lower Hct and Hb levels than do younger patients on a similar EPO dose. We believe these patients will need a more aggressive therapy with calcitriol.

Published
2002
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5. Chronic haemodialysis for very old patients.

Author

Neves PL, Sousa A, Bernardo I, Anunciada AI, Pinto I, Bexiga I, Aniceto J, and Amorim JP

Subjects
Aged, Aged, 80 and over, Cost Control trends, Female, Health Care Rationing economics, Humans, Kidney Failure, Chronic economics, Kidney Failure, Chronic etiology, Male, Portugal, Quality of Life, Treatment Outcome, Kidney Failure, Chronic therapy, Renal Dialysis economics
Abstract

There is in the Western World a progressive ageing of the population, and consequently haemodialysis patients are also getting older. Some ethical questions have been raised as a consequence of the economic issues related to the scarcity of available resources. In this paper we review our experience in the treatment of very old chronic haemodialysis patients. Fifty patients (7.2% of our haemodialysis patients) aged over 80 years at the beginning of dialysis were included (f = 25, m = 26, age = 82.6 +/- 0.3 years). In 42% of the patients the aetiology of renal disease was unknown. In the remainder, the aetiology was: interstitial nephritis 26%, hypertensive nephrosclerosis 14%, chronic glomerulonephritis 8%, diabetes 8% and polycystic disease 2%. There was a great comorbidity: intradialytic hypotension 82%, cardiac disease 74%, gastrointestinal disease 32%, cerebrovascular disease 26%. Vascular access related problems were the main reason for hospitalization. The major cause of death was vascular (cardiac and cerebral disease). Actuarial survival was 89%, 78%, 56% and 48% at 6, 12, 24 and 36 months, respectively. We think that haemodialysis is the best available choice for treating very old chronic renal failure patients. However further studies are needed to improve the quality of life of these patients.

Published
1994
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6. [Chronic hemodialysis with acetate in patients over 70 years old].

Author

Neves PL, Bexiga I, Pinto I, and Amorim JP

Subjects
Aged, Aged, 80 and over, Female, Humans, Kidney Diseases complications, Male, Time Factors, Acetates administration & dosage, Kidney Diseases therapy, Renal Dialysis
Abstract

During the last years there has a significant increase of elderly patients included in chronic dialysis programs. No agreement has been reached about the preferable treatment modality. In this study we analyse our experience in the management of patients over 70 years of age undergoing chronic acetate hemodialysis (HDCA). Sixty four of those patients have initiated HDCA between May 1982 and December 1990 (Mean age 75.9 +/- 4.8). The etiology of renal disease was unknown in a significant number of cases. Morbility was largely due to vascular disease (both cardiac and cerebral). Main causes of death were also vascular disease and infections. Actuarial survival was 79.6% at 12 months and 46.3% after 5 years. Although HDCA is associated with a greater morbility it is the most widely used modality of treatment for chronic renal failure in Portugal and in our experience, it is an acceptable method for elderly patients.

Published
1992

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