1. A CMOS, fully integrated sensor for electronic detection of DNA hybridization
- Author
-
Andrea Alessandrini, Paolo Facci, Massimo Barbaro, Annalisa Bonfiglio, I. BarakBarak, and Luigi Raffo
- Subjects
Bioelectronics ,Materials science ,Detector ,Transistor ,FET ,Nanotechnology ,Hardware_PERFORMANCEANDRELIABILITY ,Integrated circuit ,biosensor ,Electronic, Optical and Magnetic Materials ,law.invention ,Capacitor ,CMOS ,Hardware_GENERAL ,law ,MOSFET ,Hardware_INTEGRATEDCIRCUITS ,Hardware_ARITHMETICANDLOGICSTRUCTURES ,Electrical and Electronic Engineering ,CHARGE ,Biosensor - Abstract
An integrated field-effect device for fully electronic deoxyribonucleic acid (DNA) detection was realized in a standard CMOS process. The device is composed of a floating-gate MOS transistor, a control-capacitor acting as integrated counterelectrode, and an exposed active area for DNA immobilization. The drain-current of the transistor is modulated by the electric charge carried by the DNA molecules. After DNA hybridization, this charge increases and a change in the output current is measured. Experimental results are provided. Full compatibility with a standard CMOS process-opens the way to the realization of low-cost large-scale integration of fast electronic DNA detectors.
- Published
- 2006