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1. Advances in Plant Phenolics: From Chemistry to Human Health

Author

G. K. Jayaprakasha, Bhimangouda S. Patil, Giuseppe Gattuso, Jie Li, P. Annécie Benatrehina, Andrea L. Rague, Li Pan, A. Douglas Kinghorn, C. Benjamin Naman, Daniel Petinatti Pavarini, Anelize Bauermeister, João Semir, Marcelo Monge, João Luís Callegari Lopes, Norberto Peporine Lopes, Živoslav Lj. Tešić, Uroš M. Gašić, Dušanka M. Milojković-Opsenica, Davide Barreca, Ersilia Bellocco, Silvana Ficarra, Giuseppina Laganà, Antonio Galtieri, Ester Tellone, G. Yalcin, C. Demirbag, I. Bahsi, L. Ozgul, D. Bilgic Alkaya, H. I. Onurlu, S. Ayaz Seyhan, Jashbir Singh, Bhimanagouda S. Patil, D. Aoki, Y. Matsushita, K. Fukushima, Haripriya Shanmugam, Guddadarangavvanahally K. Jayaprakasha, G. A. Nagana Gowda, Daniel Raftery, Yu Zhang, Shiguo Chen, Yu Fu, Haihua Yang, Xingqian Ye, Muntha K. Reddy, Jinhee Kim, Eun-Jin Park, Deepak M. Kasote, Dipayan Sarkar, Kalidas Shetty, J. F. Stevens, J. S. Revel, José Fernando Rinaldi de Alvarenga, Julián Lozano-Castellón, Miriam Martínez-Huélamo, Anna Vallverdú-Queralt, Rosa María Lamuela-Raventós, Jerzy Zawistowski, Anet, G. K. Jayaprakasha, Bhimangouda S. Patil, Giuseppe Gattuso, Jie Li, P. Annécie Benatrehina, Andrea L. Rague, Li Pan, A. Douglas Kinghorn, C. Benjamin Naman, Daniel Petinatti Pavarini, Anelize Bauermeister, João Semir, Marcelo Monge, João Luís Callegari Lopes, Norberto Peporine Lopes, Živoslav Lj. Tešić, Uroš M. Gašić, Dušanka M. Milojković-Opsenica, Davide Barreca, Ersilia Bellocco, Silvana Ficarra, Giuseppina Laganà, Antonio Galtieri, Ester Tellone, G. Yalcin, C. Demirbag, I. Bahsi, L. Ozgul, D. Bilgic Alkaya, H. I. Onurlu, S. Ayaz Seyhan, Jashbir Singh, Bhimanagouda S. Patil, D. Aoki, Y. Matsushita, K. Fukushima, Haripriya Shanmugam, Guddadarangavvanahally K. Jayaprakasha, G. A. Nagana Gowda, Daniel Raftery, Yu Zhang, Shiguo Chen, Yu Fu, Haihua Yang, Xingqian Ye, Muntha K. Reddy, Jinhee Kim, Eun-Jin Park, Deepak M. Kasote, Dipayan Sarkar, Kalidas Shetty, J. F. Stevens, J. S. Revel, José Fernando Rinaldi de Alvarenga, Julián Lozano-Castellón, Miriam Martínez-Huélamo, Anna Vallverdú-Queralt, Rosa María Lamuela-Raventós, Jerzy Zawistowski, and Anet

Subjects
Phenols--Physiological effect, Phytochemicals--Physiological effect, Phenols in the body
Published
2018

2. Evaluation of peripheral inflammatory markers, serum B12, folate, ferritin levels and clinical correlations in children with autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD).

Author

Topal Z, Tufan AE, Karadag M, Gokcen C, Akkaya C, Sarp AS, Bahsi I, and Kilinc M

Subjects
Biomarkers blood, Child, Ferritins blood, Folic Acid blood, Humans, Vitamin B 12 blood, Attention Deficit Disorder with Hyperactivity diagnosis, Attention Deficit Disorder with Hyperactivity epidemiology, Autism Spectrum Disorder diagnosis, Autism Spectrum Disorder epidemiology
Abstract

Aim: The aim of the current study is to compare serum B12, folate, and ferritin levels and peripheral inflammatory indicators between children with Autism Spectrum Disorders (ASD), Attention Deficit Hyperactivity Disorder (ADHD), and healthy controls (HC) and to evaluate the correlation of those with symptoms., Materials and Methods: A total of 203 children were evaluated (ASD = 72; ADHD = 61; HC = 70). Diagnoses of ASD and ADHD were ascertained according to Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime Version (K-SADS-PL). Control group was chosen among the healthy children who applied to general pediatrics outpatient clinic. Gilliam Autism Rating Scale-2 is used to assess autistic symptoms and Atilla Turgay DSM-IV Based Child and Adolescent Behavior Disorders Screening and Rating Scale is used for ADHD symptoms., Results: Neutrophil levels ( p  = 0.014) and neutrophil/lymphocyte ratio (NLR) ( p  = 0.016) were higher in the ADHD and ASD groups compared to HC. Neutrophil values explained 70.1% of the variance across groups while NLR explained a further 29.9% of the variance. NLR significantly correlated with social interaction problems in ASD ( r  = 0.26, p  = 0.04). There were no significant differences between groups in terms of vitamin B12, folate and ferritin levels., Conclusion: Our results may support involvement of inflammation in the underlying pathophysiology of neurodevelopmental disorders. However, these parameters should be analyzed in a wider population to clarify the effect on the etiology and symptomatology of neurodevelopmental disorders.

Published
2022
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