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THE CONCENTRATION OF HSP70 IN THE CYTOSOL AND MITOCHONDRIA OF THE BRAIN IN ANIMALS WITH EXPERIMENTAL AUTOIMMUNE ENCEPHALO- MYELITIS AND AFTER THE TIME COURSE OF INTRANASALLY ADMINISTERED N-PHENYLACETYL-L-PROLYLGLYCINE ETHYL ESTER (NOOPEPT)

The current stage of social and economic development of Ukraine, entry into European educational space, modern processes of social and economic development determine the need for theoretical comprehension, and qualitative updating of the professional training in higher medical educational institutions, and the learning process requires further development. Aim — to increase educational process efficiency, and form a skill to perceive, comprehend independently any visual or verbal information, make their own substantiated decisions, determine the optimal ways to implement this solution from professional point of view. Material and methods. In recent years, the modernization of the Ukrainian medical education is focused on finding new, effective methods of learning. On the basis of content analysis of key conceptions of the study, it has been established that the case method is not only a realistic description of the events, but integrated information system that allows understanding the situation. Results. New educational standards of higher medical education are focused on the implementation of competence-based approach to the process of training for future physicians. Lecturer should focus on personal and professional individuality of each student, and use a differentiated approach in the learning process, as well as interactive forms and methods of teaching. For the realization of these objectives the lecture has to learn to design practical classes, preferring modern active and interactive learning methods and technologies, among which — the case method. Introduction of case technologies in educational process contrib-utes to the development of skills in students to make competent and constructive actions during conduction of effective and safe pharmacotherapy. In a competency-based approach, evaluations rests on a methodology linked on one hand, to the nature of the problem situation or situational task fac-ing the student being evaluated and, on the other, to the analysis of results ob-tained during the course of study or at the end of training. A key role belongs to disclosure of the main ideas of case-method, as well as identifying the benefits and drawbacks of this method. The classification of case-method has been given, and the approximate algorithm of the lecturer’s and the students’ work over the case has been determined. Conclusions. The application of case study method in the study of the sub-jects “Pharmacology” and “Side effects of drugs” by the medical students allows to improve the quality of mastering of these subjects, improves the application of theoretical knowledge about drugs and their side effects, as well as ensures the development of the personality of students, their professional qualities, and clinical thinking.

A method was developed for preparing previously unreported 8-amino-substituted 7-ethyltheophyllines, potential biologically active compounds. Their physicochemical properties and diuretic activity were studied.

The aim of the work – to consider examination as a main form of control in the modern system of higher education in terms of its effectiveness as well as assess the positive aspects and shortcomings of this form of boundary control, and analyze the ways of updating the exam, its new forms, the possibility of their administration in the practice of teaching in the Medical Higher Education Institutions. The main body. The article presents the different forms of knowledge control used at the Departments of Zaporizhzhia State Medical University: initial (preliminary, diagnostic, propaedeutic), current (continuously carried out monitoring of the level of knowledge and skills of students during practical classes), boundary (control of acquired knowledge and skills after the module, course), delayed and final forms of control. The final control, the state certification, is conducted ­ is conducted in the form of state examinations, including defence of a final qualifying work. Conclusions. The main form of differentiated boundary control in the university is the examination. The study of the subject or its main section is completed by examination, and the teacher can not refuse from this form of control, if only because it is indicated in the curriculum, a mandatory to comply with document.

The design of physician programs creates special challenges for providing pharmacology education. The article presents examples pertaining to improving teaching methods in pharmacology to foreign students at Medical Department. The paper has revealed peculiarities of theoretical knowledge and practical skills acquisition in the process of teaching pharmacology, and the stimulation technics for cognitive interest of students have been discussed. In particular, it has been analyzed the contributing factors that prove the need for the introduction and regular application of interactive teaching methods, testing students, the discussion of complex and unresolved scientific problems of dynamic and constantly developing science of pharmacology, and its interaction with other modern biomedical sciences.

The paper aimed to determine the effects of mixtures of selected medicinal plants on some physiological renal functions, i.e. excretion of urine and electrolytes and changes in the quantity of prostaglandins E2 (PGE2) and kallikrein-kinins in rat blood plasma after water and salt load. The following medicinal plants were selected for the examination: downy birch (Betula pubescens EHRH.), everlasting flower (Helichrysum arenarium L. MOENCH.), hawthorn (Crataegus oxyacantha L.), woodland strawberry (Fragaria vesca L.), sweet corn (Zea mays L.), German chamomile (Matricaria recutita L.), and field horsetail (Equisetum arvense L.). Herbal drugs were used to compose 6 mixtures. Extracts from these mixtures were administered to Wistar strain males and their effects were compared with the effects of an administered suspension of hydrochlorothiazide, an extract from field horsetail herb alone, and a control group of animals which was not administered any preparation. The greatest diuretic effect was found in a mixture composed of birch leaves (Betulae folium), hawthorn berries (Crataegi fructus), strawberry leaves (Fragariae folium), corn silk (Maydis stigmata), chamomile flowers (Matricariae flos), and horsetail herb (Equiseti herba). Its effect was greater by 47% and 34% than the effect of a horsetail herb extract and a hydrochlorothiazide suspension (p0.05), respectively. The extract from this mixture also increased the quantity of prostaglandins E2 and kallikrein-kinins in rat blood plasma in water and salt load.