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6. Empagliflozin in the treatment of heart failure with reduced ejection fraction in addition to background therapies and therapeutic combinations (EMPEROR-Reduced): a post-hoc analysis of a randomised, double-blind trial

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Subodh Verma, Nitish K Dhingra, Javed Butler, Stefan D Anker, Joao Pedro Ferreira, Gerasimos Filippatos, James L Januzzi, Carolyn S P Lam, Naveed Sattar, Barbara Peil, Matias Nordaby, Martina Brueckmann, Stuart J Pocock, Faiez Zannad, Milton Packer, M Packer, S Anker, J Butler, G Filippatos, S Pocock, F Zannad, JP Ferreira, M Brueckmann, J George, W Jamal, FK Welty, M Palmer, T Clayton, KG Parhofer, TR Pedersen, B Greenberg, MA Konstam, KR Lees, P Carson, W Doehner, A Miller, M Haas, S Pehrson, M Komajda, I Anand, J Teerlink, A Rabinstein, T Steiner, H Kamel, G Tsivgoulis, J Lewis, J Freston, N Kaplowitz, J Mann, J Petrie, S Perrone, S Nicholls, S Janssens, E Bocchi, N Giannetti, S Verma, J Zhang, J Spinar, M-F Seronde, M Boehm, B Merkely, V Chopra, M Senni, S Taddi, H Tsutsui, D-J Choi, E Chuquiure, HPB La Rocca, P Ponikowski, JRG Juanatey, I Squire, J Januzzi, I Pina, R Bernstein, A Cheung, J Green, S Kaul, C Lam, G Lip, N Marx, P McCullough, C Mehta, J Rosenstock, N Sattar, B Scirica, S Shah, C Wanner, D Aizenberg, L Cartasegna, F Colombo Berra, H Colombo, M Fernandez Moutin, J Glenny, C Alvarez Lorio, D Anauch, R Campos, A Facta, A Fernandez, R Ahuad Guerrero, L Lobo Márquez, RA Leon de la Fuente, M Mansilla, M Hominal, E Hasbani, M Najenson, G Moises Azize, H Luquez, L Guzman, H Sessa, M Amuchástegui, O Salomone, E Perna, D Piskorz, M Sicer, D Perez de Arenaza, C Zaidman, S Nani, C Poy, J Resk, R Villarreal, C Majul, T Smith Casabella, S Sassone, A Liberman, G Carnero, A Caccavo, M Berli, N Budassi, J Bono, A Alvarisqueta, J Amerena, K Kostner, A Hamilton, A Begg, J Beltrame, D Colquhoun, G Gordon, A Sverdlov, G Vaddadi, J Wong, J Coller, D Prior, A Friart, A Leone, G Vervoort, P Timmermans, P Troisfontaines, C Franssen, T Sarens, H Vandekerckhove, P Van De Borne, F Chenot, J De Sutter, E De Vuyst, P Debonnaire, M Dupont, O Pereira Dutra, LH Canani, MdC Vieira Moreira, W de Souza, LM Backes, L Maia, B De Souza Paolino, ER Manenti, W Saporito, F Villaça Guimarães Filho, T Franco Hirakawa, LA Saliba, FC Neuenschwander, CA de Freitas Zerbini, G Gonçalves, Y Gonçalves Mello, J Ascenção de Souza, L Beck da Silva Neto, EA Bocchi, J Da Silveira, JB de Moura Xavier Moraes Junior, JD de Souza Neto, M Hernandes, HC Finimundi, CR Sampaio, E Vasconcellos, FJ Neves Mancuso, MM Noya Rabelo, M Rodrigues Bacci, F Santos, M Vidotti, MV Simões, FL Gomes, C Vieira Nascimento, D Precoma, FA Helfenstein Fonseca, JA Ribas Fortes, PE Leães, D Campos de Albuquerque, JF Kerr Saraiva, S Rassi, FA Alves da Costa, G Reis, S Zieroth, D Dion, D Savard, R Bourgeois, C Constance, K Anderson, M-H Leblanc, D Yung, E Swiggum, L Pliamm, Y Pesant, B Tyrrell, T Huynh, J Spiegelman, J-P Lavoie, M Hartleib, R Bhargava, L Straatman, S Virani, A Costa-Vitali, L Hill, M Heffernan, Y Khaykin, J Ricci, M Senaratne, A Zhai, B Lubelsky, M Toma, L Yao, R McKelvie, L Noronha, M Babapulle, A Pandey, G Curnew, A Lavoie, J Berlingieri, S Kouz, E Lonn, R Chehayeb, Y Zheng, Y Sun, H Cui, Z Fan, X Han, X Jiang, Q Tang, J Zhou, Z Zheng, X Zhang, N Zhang, Y Zhang, A Shen, J Yu, J Ye, Y Yao, J Yan, X Xu, Z Wang, J Ma, Y Li, S Li, S Lu, X Kong, Y Song, G Yang, Z Yao, Y Pan, X Guo, Z Sun, Y Dong, J Zhu, D Peng, Z Yuan, J Lin, Y Yin, O Jerabek, H Burianova, T Fiala, J Hubac, O Ludka, Z Monhart, P Vodnansky, K Zeman, D Foldyna, J Krupicka, I Podpera, L Busak, M Radvan, Z Vomacka, R Prosecky, R Cifkova, V Durdil, J Vesely, J Vaclavik, P Cervinka, A Linhart, T Brabec, R Miklik, H Bourhaial, H-G Olbrich, S Genth-Zotz, E Kemala, B Lemke, M Böhm, S Schellong, W Rieker, T Heitzer, H Ince, M Faghih, A Birkenfeld, A Begemann, A Ghanem, A Ujeyl, S von Haehling, T Dorsel, J Bauersachs, M Prull, F Weidemann, H Darius, G Nickenig, A Wilke, J Sauter, U Rauch-Kroehnert, N Frey, CP Schulze, W König, L Maier, F Menzel, N Proskynitopoulos, H-H Ebert, H-E Sarnighausen, H-D Düngen, M Licka, C Stellbrink, B Winkelmann, N Menck, JL López-Sendón, L de la Fuente Galán, JF Delgado Jiménez, N Manito Lorite, M Pérez de Juan Romero, E Galve Basilio, F Cereto Castro, JR González Juanatey, JJ Gómez, M Sanmartín Fernández, X Garcia-Moll Marimon, D Pascual Figal, R Bover Freire, E Bonnefoy Cudraz, A Jobbe Duval, D Tomasevic, G Habib, R Isnard, F Picard, P Khanoyan, J-L Dubois-Rande, M Galinier, F Roubille, J Alexandre, D Babuty, N Delarche, J-B Berneau, N Girerd, M Saxena, G Rosano, Z Yousef, C Clifford, C Arden, A Bakhai, C Boos, G Jenkins, C Travill, D Price, L Koenyves, F Lakatos, A Matoltsy, E Noori, Z Zilahi, P Andrassy, S Kancz, G Simon, T Sydo, A Vorobcsuk, RG Kiss, K Toth, I Szakal, L Nagy, T Barany, A Nagy, E Szolnoki, VK Chopra, S Mandal, V Rastogi, B Shah, A Mullasari, J Shankar, V Mehta, A Oomman, U Kaul, S Komarlu, D Kahali, A Bhagwat, V Vijan, NK Ghaisas, A Mehta, J Kashyap, Y Kothari, S TaddeI, M Scherillo, V Zacà, S Genovese, A Salvioni, A Fucili, F Fedele, F Cosmi, M Volpe, C Mazzone, G Esposito, M Doi, H Yamamoto, S Sakagami, S Oishi, Y Yasaka, H Tsuboi, Y Fujino, S Matsuoka, Y Watanabe, T Himi, T Ide, M Ichikawa, Y Kijima, T Koga, S Yuda, K Fukui, T Kubota, M Manita, H Fujinaga, T Matsumura, Y Fukumoto, R Kato, Y Kawai, G Hiasa, Y Kazatani, M Mori, A Ogimoto, M Inoko, M Oguri, M Kinoshita, K Okuhara, N Watanabe, Y Ono, K Otomo, Y Sato, T Matsunaga, A Takaishi, N Miyagi, H Uehara, H Takaishi, H Urata, T Kataoka, H Matsubara, T Matsumoto, T Suzuki, N Takahashi, M Imamaki, T Yoshitama, T Saito, H Sekino, Y Furutani, M Koda, T Shinozaki, K Hirabayashi, R Tsunoda, K Yonezawa, H Hori, M Yagi, M Arikawa, T Hashizume, R Ishiki, T Koizumi, K Nakayama, S Taguchi, M Nanasato, Y Yoshida, S Tsujiyama, T Nakamura, K Oku, M Shimizu, M Suwa, Y Momiyama, H Sugiyama, K Kobayashi, S Inoue, T Kadokami, K Maeno, K Kawamitsu, Y Maruyama, A Nakata, T Shibata, A Wada, H-J Cho, JO Na, B-S Yoo, J-O Choi, SK Hong, J-H Shin, M-C Cho, SH Han, J-O Jeong, J-J Kim, SM Kang, D-S Kim, MH Kim, G Llamas Esperon, J Illescas Díaz, P Fajardo Campos, J Almeida Alvarado, A Bazzoni Ruiz, J Echeverri Rico, I Lopez Alcocer, L Valle Molina, C Hernandez Herrera, C Calvo Vargas, FG Padilla Padilla, I Rodriguez Briones, EJJR Chuquiure Valenzuela, ME Aguilera Real, J Carrillo Calvillo, M Alpizar Salazar, JL Cervantes Escárcega, R Velasco Sanchez, N Al - Windy, L van Heerebeek, L Bellersen, H-P Brunner-La Rocca, J Post, GCM Linssen, M van de Wetering, R Peters, R van Stralen, R Groutars, P Smits, A Yilmaz, WEM Kok, P Van der Meer, P Dijkmans, R Troquay, AP van Alem, R Van de Wal, L Handoko, ICD Westendorp, PFMM van Bergen, BJWM Rensing, P Hoogslag, B Kietselaer, JA Kragten, FR den Hartog, A Alings, L Danilowicz-Szymanowicz, G Raczak, W Piesiewicz, W Zmuda, W Kus, P Podolec, W Musial, G Drelich, G Kania, P Miekus, S Mazur, A Janik, J Spyra, J Peruga, P Balsam, B Krakowiak, J Szachniewicz, M Ginel, J Grzybowski, W Chrustowski, P Wojewoda, A Kalinka, A Zurakowski, R Koc, M Debinski, W Fil, M Kujawiak, J Forys, M Kasprzak, M Krol, P Michalski, E Mirek-Bryniarska, K Radwan, G Skonieczny, K Stania, G Skoczylas, A Madej, J Jurowiecki, B Firek, B Wozakowska-Kaplon, K Cymerman, J Neutel, K Adams, P Balfour, A Deswal, A Djamson, P Duncan, M Hong, C Murray, D Rinde-Hoffman, S Woodhouse, R MacNevin, B Rama, C Broome-Webster, S Kindsvater, D Abramov, M Barettella, S Pinney, J Herre, A Cohen, K Vora, K Challappa, S West, S Baum, J Cox, S Jani, A Karim, A Akhtar, O Quintana, L Paukman, R Goldberg, Z Bhatti, M Budoff, E Bush, A Potler, R Delgado, B Ellis, J Dy, J Fialkow, R Sangrigoli, K Ferdinand, C East, S Falkowski, S Donahoe, R Ebrahimi, G Kline, B Harris, R Khouzam, N Jaffrani, N Jarmukli, N Kazemi, M Koren, K Friedman, W Herzog, J Silva Enciso, D Cheung, M Grover-McKay, P Hauptman, D Mikhalkova, V Hegde, J Hodsden, S Khouri, F McGrew, R Littlefield, P Bradley, B McLaurin, S Lupovitch, I Labin, V Rao, M Leithe, M Lesko, N Lewis, D Lombardo, S Mahal, V Malhotra, I Dauber, A Banerjee, J Needell, G Miller, L Paladino, K Munuswamy, M Nanna, E McMillan, M Mumma, M Napoli, W Nelson, T O'Brien, A Adlakha, A Onwuanyi, H Serota, J Schmedtje, A Paraschos, R Potu, C Sai-Sudhakar, M Saltzberg, A Sauer, P Shah, H Skopicki, H Bui, K Carr, G Stevens, N Tahirkheli, J Tallaj, K Yousuf, B Trichon, J Welker, P Tolerico, A Vest, R Vivo, X Wang, R Abadier, S Dunlap, N Weintraub, A Malik, P Kotha, V Zaha, G Kim, N Uriel, T Greene, A Salacata, R Arora, R Gazmuri, J Kobayashi, B Iteld, R Vijayakrishnan, R Dab, Z Mirza, V Marques, M Nallasivan, D Bensimhon, B Peart, H Saint-Jacques, K Barringhaus, J Contreras, A Gupta, S Koneru, V Nguyen, Verma, S, Dhingra, N, Butler, J, Anker, S, Ferreira, J, Filippatos, G, Januzzi, J, Lam, C, Sattar, N, Peil, B, Nordaby, M, Brueckmann, M, Pocock, S, Zannad, F, Packer, M, George, J, Jamal, W, Welty, F, Palmer, M, Clayton, T, Parhofer, K, Pedersen, T, Greenberg, B, Konstam, M, Lees, K, Carson, P, Doehner, W, Miller, A, Haas, M, Pehrson, S, Komajda, M, Anand, I, Teerlink, J, Rabinstein, A, Steiner, T, Kamel, H, Tsivgoulis, G, Lewis, J, Freston, J, Kaplowitz, N, Mann, J, Petrie, J, Perrone, S, Nicholls, S, Janssens, S, Bocchi, E, Giannetti, N, Zhang, J, Spinar, J, Seronde, M, Boehm, M, Merkely, B, Chopra, V, Senni, M, Taddi, S, Tsutsui, H, Choi, D, Chuquiure, E, La Rocca, H, Ponikowski, P, Juanatey, J, Squire, I, Pina, I, Bernstein, R, Cheung, A, Green, J, Kaul, S, Lip, G, Marx, N, Mccullough, P, Mehta, C, Rosenstock, J, Scirica, B, Shah, S, Wanner, C, Aizenberg, D, Cartasegna, L, Colombo Berra, F, Colombo, H, Fernandez Moutin, M, Glenny, J, Alvarez Lorio, C, Anauch, D, Campos, R, Facta, A, Fernandez, A, Ahuad Guerrero, R, Lobo Marquez, L, Leon de la Fuente, R, Mansilla, M, Hominal, M, Hasbani, E, Najenson, M, Moises Azize, G, Luquez, H, Guzman, L, Sessa, H, Amuchastegui, M, Salomone, O, Perna, E, Piskorz, D, Sicer, M, Perez de Arenaza, D, Zaidman, C, Nani, S, Poy, C, Resk, J, Villarreal, R, Majul, C, Smith Casabella, T, Sassone, S, Liberman, A, Carnero, G, Caccavo, A, Berli, M, Budassi, N, Bono, J, Alvarisqueta, A, Amerena, J, Kostner, K, Hamilton, A, Begg, A, Beltrame, J, Colquhoun, D, Gordon, G, Sverdlov, A, Vaddadi, G, Wong, J, Coller, J, Prior, D, Friart, A, Leone, A, Vervoort, G, Timmermans, P, Troisfontaines, P, Franssen, C, Sarens, T, Vandekerckhove, H, Van De Borne, P, Chenot, F, De Sutter, J, De Vuyst, E, Debonnaire, P, Dupont, M, Pereira Dutra, O, Canani, L, Vieira Moreira, M, de Souza, W, Backes, L, Maia, L, De Souza Paolino, B, Manenti, E, Saporito, W, Villaca Guimaraes Filho, F, Franco Hirakawa, T, Saliba, L, Neuenschwander, F, de Freitas Zerbini, C, Goncalves, G, Goncalves Mello, Y, Ascencao de Souza, J, Beck da Silva Neto, L, Da Silveira, J, de Moura Xavier Moraes Junior, J, de Souza Neto, J, Hernandes, M, Finimundi, H, Sampaio, C, Vasconcellos, E, Neves Mancuso, F, Noya Rabelo, M, Rodrigues Bacci, M, Santos, F, Vidotti, M, Simoes, M, Gomes, F, Vieira Nascimento, C, Precoma, D, Helfenstein Fonseca, F, Ribas Fortes, J, Leaes, P, Campos de Albuquerque, D, Kerr Saraiva, J, Rassi, S, Alves da Costa, F, Reis, G, Zieroth, S, Dion, D, Savard, D, Bourgeois, R, Constance, C, Anderson, K, Leblanc, M, Yung, D, Swiggum, E, Pliamm, L, Pesant, Y, Tyrrell, B, Huynh, T, Spiegelman, J, Lavoie, J, Hartleib, M, Bhargava, R, Straatman, L, Virani, S, Costa-Vitali, A, Hill, L, Heffernan, M, Khaykin, Y, Ricci, J, Senaratne, M, Zhai, A, Lubelsky, B, Toma, M, Yao, L, Mckelvie, R, Noronha, L, Babapulle, M, Pandey, A, Curnew, G, Lavoie, A, Berlingieri, J, Kouz, S, Lonn, E, Chehayeb, R, Zheng, Y, Sun, Y, Cui, H, Fan, Z, Han, X, Jiang, X, Tang, Q, Zhou, J, Zheng, Z, Zhang, X, Zhang, N, Zhang, Y, Shen, A, Yu, J, Ye, J, Yao, Y, Yan, J, Xu, X, Wang, Z, Ma, J, Li, Y, Li, S, Lu, S, Kong, X, Song, Y, Yang, G, Yao, Z, Pan, Y, Guo, X, Sun, Z, Dong, Y, Zhu, J, Peng, D, Yuan, Z, Lin, J, Yin, Y, Jerabek, O, Burianova, H, Fiala, T, Hubac, J, Ludka, O, Monhart, Z, Vodnansky, P, Zeman, K, Foldyna, D, Krupicka, J, Podpera, I, Busak, L, Radvan, M, Vomacka, Z, Prosecky, R, Cifkova, R, Durdil, V, Vesely, J, Vaclavik, J, Cervinka, P, Linhart, A, Brabec, T, Miklik, R, Bourhaial, H, Olbrich, H, Genth-Zotz, S, Kemala, E, Lemke, B, Bohm, M, Schellong, S, Rieker, W, Heitzer, T, Ince, H, Faghih, M, Birkenfeld, A, Begemann, A, Ghanem, A, Ujeyl, A, von Haehling, S, Dorsel, T, Bauersachs, J, Prull, M, Weidemann, F, Darius, H, Nickenig, G, Wilke, A, Sauter, J, Rauch-Kroehnert, U, Frey, N, Schulze, C, Konig, W, Maier, L, Menzel, F, Proskynitopoulos, N, Ebert, H, Sarnighausen, H, Dungen, H, Licka, M, Stellbrink, C, Winkelmann, B, Menck, N, Lopez-Sendon, J, de la Fuente Galan, L, Delgado Jimenez, J, Manito Lorite, N, Perez de Juan Romero, M, Galve Basilio, E, Cereto Castro, F, Gonzalez Juanatey, J, Gomez, J, Sanmartin Fernandez, M, Garcia-Moll Marimon, X, Pascual Figal, D, Bover Freire, R, Bonnefoy Cudraz, E, Jobbe Duval, A, Tomasevic, D, Habib, G, Isnard, R, Picard, F, Khanoyan, P, Dubois-Rande, J, Galinier, M, Roubille, F, Alexandre, J, Babuty, D, Delarche, N, Berneau, J, Girerd, N, Saxena, M, Rosano, G, Yousef, Z, Clifford, C, Arden, C, Bakhai, A, Boos, C, Jenkins, G, Travill, C, Price, D, Koenyves, L, Lakatos, F, Matoltsy, A, Noori, E, Zilahi, Z, Andrassy, P, Kancz, S, Simon, G, Sydo, T, Vorobcsuk, A, Kiss, R, Toth, K, Szakal, I, Nagy, L, Barany, T, Nagy, A, Szolnoki, E, Mandal, S, Rastogi, V, Shah, B, Mullasari, A, Shankar, J, Mehta, V, Oomman, A, Kaul, U, Komarlu, S, Kahali, D, Bhagwat, A, Vijan, V, Ghaisas, N, Mehta, A, Kashyap, J, Kothari, Y, Taddei, S, Scherillo, M, Zaca, V, Genovese, S, Salvioni, A, Fucili, A, Fedele, F, Cosmi, F, Volpe, M, Mazzone, C, Esposito, G, Doi, M, Yamamoto, H, Sakagami, S, Oishi, S, Yasaka, Y, Tsuboi, H, Fujino, Y, Matsuoka, S, Watanabe, Y, Himi, T, Ide, T, Ichikawa, M, Kijima, Y, Koga, T, Yuda, S, Fukui, K, Kubota, T, Manita, M, Fujinaga, H, Matsumura, T, Fukumoto, Y, Kato, R, Kawai, Y, Hiasa, G, Kazatani, Y, Mori, M, Ogimoto, A, Inoko, M, Oguri, M, Kinoshita, M, Okuhara, K, Watanabe, N, Ono, Y, Otomo, K, Sato, Y, Matsunaga, T, Takaishi, A, Miyagi, N, Uehara, H, Takaishi, H, Urata, H, Kataoka, T, Matsubara, H, Matsumoto, T, Suzuki, T, Takahashi, N, Imamaki, M, Yoshitama, T, Saito, T, Sekino, H, Furutani, Y, Koda, M, Shinozaki, T, Hirabayashi, K, Tsunoda, R, Yonezawa, K, Hori, H, Yagi, M, Arikawa, M, Hashizume, T, Ishiki, R, Koizumi, T, Nakayama, K, Taguchi, S, Nanasato, M, Yoshida, Y, Tsujiyama, S, Nakamura, T, Oku, K, Shimizu, M, Suwa, M, Momiyama, Y, Sugiyama, H, Kobayashi, K, Inoue, S, Kadokami, T, Maeno, K, Kawamitsu, K, Maruyama, Y, Nakata, A, Shibata, T, Wada, A, Cho, H, Na, J, Yoo, B, Choi, J, Hong, S, Shin, J, Cho, M, Han, S, Jeong, J, Kim, J, Kang, S, Kim, D, Kim, M, Llamas Esperon, G, Illescas Diaz, J, Fajardo Campos, P, Almeida Alvarado, J, Bazzoni Ruiz, A, Echeverri Rico, J, Lopez Alcocer, I, Valle Molina, L, Hernandez Herrera, C, Calvo Vargas, C, Padilla Padilla, F, Rodriguez Briones, I, Chuquiure Valenzuela, E, Aguilera Real, M, Carrillo Calvillo, J, Alpizar Salazar, M, Cervantes Escarcega, J, Velasco Sanchez, R, Al - Windy, N, van Heerebeek, L, Bellersen, L, Brunner-La Rocca, H, Post, J, Linssen, G, van de Wetering, M, Peters, R, van Stralen, R, Groutars, R, Smits, P, Yilmaz, A, Kok, W, Van der Meer, P, Dijkmans, P, Troquay, R, van Alem, A, Van de Wal, R, Handoko, L, Westendorp, I, van Bergen, P, Rensing, B, Hoogslag, P, Kietselaer, B, Kragten, J, den Hartog, F, Alings, A, Danilowicz-Szymanowicz, L, Raczak, G, Piesiewicz, W, Zmuda, W, Kus, W, Podolec, P, Musial, W, Drelich, G, Kania, G, Miekus, P, Mazur, S, Janik, A, Spyra, J, Peruga, J, Balsam, P, Krakowiak, B, Szachniewicz, J, Ginel, M, Grzybowski, J, Chrustowski, W, Wojewoda, P, Kalinka, A, Zurakowski, A, Koc, R, Debinski, M, Fil, W, Kujawiak, M, Forys, J, Kasprzak, M, Krol, M, Michalski, P, Mirek-Bryniarska, E, Radwan, K, Skonieczny, G, Stania, K, Skoczylas, G, Madej, A, Jurowiecki, J, Firek, B, Wozakowska-Kaplon, B, Cymerman, K, Neutel, J, Adams, K, Balfour, P, Deswal, A, Djamson, A, Duncan, P, Hong, M, Murray, C, Rinde-Hoffman, D, Woodhouse, S, Macnevin, R, Rama, B, Broome-Webster, C, Kindsvater, S, Abramov, D, Barettella, M, Pinney, S, Herre, J, Cohen, A, Vora, K, Challappa, K, West, S, Baum, S, Cox, J, Jani, S, Karim, A, Akhtar, A, Quintana, O, Paukman, L, Goldberg, R, Bhatti, Z, Budoff, M, Bush, E, Potler, A, Delgado, R, Ellis, B, Dy, J, Fialkow, J, Sangrigoli, R, Ferdinand, K, East, C, Falkowski, S, Donahoe, S, Ebrahimi, R, Kline, G, Harris, B, Khouzam, R, Jaffrani, N, Jarmukli, N, Kazemi, N, Koren, M, Friedman, K, Herzog, W, Silva Enciso, J, Cheung, D, Grover-McKay, M, Hauptman, P, Mikhalkova, D, Hegde, V, Hodsden, J, Khouri, S, Mcgrew, F, Littlefield, R, Bradley, P, Mclaurin, B, Lupovitch, S, Labin, I, Rao, V, Leithe, M, Lesko, M, Lewis, N, Lombardo, D, Mahal, S, Malhotra, V, Dauber, I, Banerjee, A, Needell, J, Miller, G, Paladino, L, Munuswamy, K, Nanna, M, Mcmillan, E, Mumma, M, Napoli, M, Nelson, W, O'Brien, T, Adlakha, A, Onwuanyi, A, Serota, H, Schmedtje, J, Paraschos, A, Potu, R, Sai-Sudhakar, C, Saltzberg, M, Sauer, A, Shah, P, Skopicki, H, Bui, H, Carr, K, Stevens, G, Tahirkheli, N, Tallaj, J, Yousuf, K, Trichon, B, Welker, J, Tolerico, P, Vest, A, Vivo, R, Wang, X, Abadier, R, Dunlap, S, Weintraub, N, Malik, A, Kotha, P, Zaha, V, Kim, G, Uriel, N, Greene, T, Salacata, A, Arora, R, Gazmuri, R, Kobayashi, J, Iteld, B, Vijayakrishnan, R, Dab, R, Mirza, Z, Marques, V, Nallasivan, M, Bensimhon, D, Peart, B, Saint-Jacques, H, Barringhaus, K, Contreras, J, Gupta, A, Koneru, S, Nguyen, V, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)

Subjects
Male, medicine.medical_specialty, Angiotensin receptor, Glucoside, Endocrinology, Diabetes and Metabolism, [SDV]Life Sciences [q-bio], Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Adrenergic beta-Antagonists, Angiotensin-Converting Enzyme Inhibitors, 030204 cardiovascular system & hematology, Placebo, 03 medical and health sciences, Angiotensin Receptor Antagonists, 0302 clinical medicine, Endocrinology, Mineralocorticoid receptor, Glucosides, Double-Blind Method, Internal medicine, Post-hoc analysis, Internal Medicine, medicine, Empagliflozin, Humans, 030212 general & internal medicine, Benzhydryl Compounds, ComputingMilieux_MISCELLANEOUS, Aged, Benzhydryl Compound, Heart Failure, Ejection fraction, business.industry, Angiotensin Receptor Antagonist, Adrenergic beta-Antagonist, Angiotensin-Converting Enzyme Inhibitor, Stroke Volume, medicine.disease, 3. Good health, Heart failure, ACE inhibitor, Female, Hypotension, business, medicine.drug, Human
Abstract

Contains fulltext : 249977.pdf (Publisher’s version ) (Closed access) BACKGROUND: It is important to evaluate whether a new treatment for heart failure with reduced ejection fraction (HFrEF) provides additive benefit to background foundational treatments. As such, we aimed to evaluate the efficacy and safety of empagliflozin in patients with HFrEF in addition to baseline treatment with specific doses and combinations of disease-modifying therapies. METHODS: We performed a post-hoc analysis of the EMPEROR-Reduced randomised, double-blind, parallel-group trial, which took place in 520 centres (hospitals and medical clinics) in 20 countries in Asia, Australia, Europe, North America, and South America. Patients with New York Heart Association (NYHA) classification II-IV with an ejection fraction of 40% or less were randomly assigned (1:1) to receive the addition of either oral empagliflozin 10 mg per day or placebo to background therapy. The primary composite outcome was cardiovascular death and heart failure hospitalisation; the secondary outcome was total heart failure hospital admissions. An extended composite outcome consisted of inpatient and outpatient HFrEF events was also evaluated. Outcomes were analysed according to background use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs) or angiotensin receptor neprilysin inhibitors (ARNIs), as well as β blockers and mineralocorticoid receptor antagonists (MRAs) at less than 50% or 50% or more of target doses and in various combinations. This study is registered with ClinicalTrials.gov, NCT03057977. FINDINGS: In this post-hoc analysis of 3730 patients (mean age 66·8 years [SD 11·0], 893 [23·9%] women; 1863 [49·9%] in the empagliflozin group, 1867 [50·1%] in the placebo group) assessed between March 6, 2017, and May 28, 2020, empagliflozin reduced the risk of the primary outcome (361 in 1863 participants in the empagliflozin group and 462 of 1867 in the placebo group; HR 0·75 [95% CI 0·65-0·86]) regardless of background therapy or its target doses for ACE inhibitors or ARBs at doses of less than 50% of the target dose (HR 0·85 [0·69-1·06]) and for doses of 50% or more of the target dose (HR 0·67 [0·52-0·88]; p(interaction)=0·18). A similar result was seen for β blockers at doses of less than 50% of the target dose (HR 0·66 [0·54-0·80]) and for doses of 50% or more of the target dose (HR 0·81 [0·66-1·00]; p(interaction)=0·15). Empagliflozin also reduced the risk of the primary outcome irrespective of background use of triple therapy with an ACE inhibitor, ARB, or ARNI plus β blocker plus MRA (given combination HR 0·73 [0·61-0·88]; not given combination HR 0·76 [0·62-0·94]; p(interaction)=0·77). Similar patterns of benefit were observed for the secondary and extended composite outcomes. Empagliflozin was well tolerated and rates of hypotension, symptomatic hypotension, and hyperkalaemia were similar across all subgroups. INTERPRETATION: Empagliflozin reduced serious heart failure outcomes across doses and combinations of disease-modifying therapies for HFrEF. Clinically, these data suggest that empagliflozin might be considered as a foundational therapy in patients with HFrEF regardless of their existing background therapy. FUNDING: Boehringer Ingelheim and Eli Lilly and Company.

Published
2022
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7. Prevalence and Influence of COVID-19 in Asthma Control and Lung Function in Severe Asthma Patients Receiving Biological Treatment

Author

Rocío Magdalena Díaz-Campos, I García-Moguel, C Melero-Moreno, I Pina-Maiquez, and C Fernández-Rodríguez

Subjects
Adult, Male, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Adolescent, Severe asthma, Immunology, Pulmonary function testing, Asthma control, Internal medicine, Prevalence, Immunology and Allergy, Medicine, Humans, Lung, Lung function, Asthma, Aged, Retrospective Studies, business.industry, SARS-CoV-2, COVID-19, Retrospective cohort study, Middle Aged, medicine.disease, Biological Therapy, Hospitalization, medicine.anatomical_structure, Female, business
Published
2021

8. Survival comparison of HER2 breast cancer patients according to HR status: analysis of a single Portuguese centre

Author

C. Trabulo, I. Pina, I. Fernandes, G. Nogueira-Costa, J. Gramaça, and J. Gonçalves

Subjects
Oncology, medicine.medical_specialty, business.industry, General Medicine, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, language.human_language, Breast cancer, Internal medicine, medicine, language, Surgery, Portuguese, business
Published
2021

9. On the quantum-limit of the noise temperature in balanced correlation receivers

Author

Miguel I. Pina, Ernest A. Michael, Daniella Pollarolo, Massinissa Hadjara, Antonio Rodriguez, and Felipe E. Besser

Subjects
Signal light, Physics, Noise temperature, business.industry, Quantum limit, Radiation, Polarization (waves), law.invention, Interferometry, Halogen lamp, Optics, law, Thermal, business
Abstract

Recent results for the cross-correlation signal of a newly proposed balanced correlation receiver at 1.5 μm pointed towards a possible bypassing of the standard quantum limit for the receiver noise-temperature hν⁄k in cross-correlation by a factor of 4-6. The only radiation source strong enough for a clear hot-cold measurement was a heavily attenuated fiber-coupled superluminant LED (SLED), because a multi-mode fiber-coupled thermal halogen lamp was difficult to control in polarization due to its weakness when coupled to a single-mode fiber. This peculiarity left some doubts regarding a possible “strange” quantum-mechanical behavior of the signal light from the SLED. Here we want to present the concept for more convincing measurements using a true thermal signal source.

Published
2020
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10. Single mode fiber coupling tip tilt control for a small amateur telescope

Author

Ernest A. Michael, Kevin Espinoza, Ricardo Jara, Nicolas Ramos, Miguel I. Pina, Massinissa Hadjara, Benjamin Cornejo, Pablo Zorzi, Alfredo Rates, Carolina Garcia, Felipe E. Besser, and Joaquin Rojas

Subjects
Physics, Coupling, Heterodyne, Optical fiber, business.industry, Controller (computing), Astrophysics::Instrumentation and Methods for Astrophysics, Single-mode optical fiber, law.invention, Telescope, Interferometry, Optics, law, Actuator, business
Abstract

The current work presents a fiber coupling tip-tilt controller developed for a three-telescope experimental prototype of an Astronomical Fiber-Based Near-Infrared Heterodyne Interferometer. It is based on a commercial magneto-mechanical compact-disk laser-beam actuator on which the fiber-ferrule is mounted. The actuator is driven by a two-axis controller electronics board which was developed by us based on digital processing in a dsPIC33EP device with analog periphery, which reads the quad-photodiode signals amplified by 109, and drives the actuator with two high-current outputs. While this realizes the very fine and relatively fast (up to 100 Hz) fiber-position control in the telescope focus, as a basis to this, a relatively coarse and slow auto-guiding is given by an amateur guiding camera. During first optical bench testing we obtained an average coupled power increase of up to 50% under certain perturbations.

Published
2020
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11. Prognostic utility of neutrophil-to-lymphocyte ratio in patients with metastatic colorectal cancer treated using different modalities

Author

R. Gameiro, A T Xavier, I. Fernandes, J. Gramaça, G. Nogueira-Costa, and I. Pina

Subjects
Adult, Male, Vascular Endothelial Growth Factor A, medicine.medical_specialty, Colorectal cancer, Neutrophils, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, 030212 general & internal medicine, Lymphocytes, Neutrophil to lymphocyte ratio, Survival analysis, Aged, Retrospective Studies, Aged, 80 and over, Receiver operating characteristic, Proportional hazards model, business.industry, Hazard ratio, fungi, Middle Aged, medicine.disease, Prognosis, nlr, metastatic, 030220 oncology & carcinogenesis, Colonic Neoplasms, Biomarker (medicine), Female, Original Article, Metastasectomy, business, metastasectomy
Abstract

Inflammation is a critical component in carcinogenesis. The neutrophil-to-lymphocyte ratio (nlr) has been retrospectively studied as a biomarker of prognosis in metastatic colorectal cancer (mcrc). Compared with a low nlr, a high nlr is associated with worse prognosis. In the present study, we compared real-world survival for patients with mcrc based on their nlr group, and we assessed the utility of the nlr in determining first-line chemotherapy and metastasectomy benefit. In this retrospective and descriptive analysis of patients with mcrc undergoing first-line chemotherapy in a single centre, the last systemic absolute neutrophil and lymphocyte count before treatment was used for the nlr. A receiver operating characteristic curve was used to estimate the nlr cut-off value, dividing the patients into low and high nlr groups. Median overall survival (mos) was compared using Kaplan&ndash, Meier curves and the log-rank test. A multivariate analysis was performed using a Cox regression model. The 102 analyzed patients had a median follow-up of 15 months. Regardless of systemic therapy, approximately 20% of patients underwent metastasectomy. The nlr cut-off was established at 2.35, placing 45 patients in the low-risk group (nlr < 2.35) and 57 in the high-risk group (nlr &ge, 2.35). The Kaplan&ndash, Meier analysis showed a mos of 39.1 months in the low-risk group and 14.4 months in the high-risk group (p < 0.001). Multivariate Cox regression on the nlr estimated a hazard ratio of 3.08 (p = 0.01). Survival analysis in each risk subgroup, considering the history of metastasectomy, was also performed. In the low-risk group, mos was longer for patients undergoing metastasectomy than for those not undergoing the procedure (95.2 months vs. 22.6 months, p = 0.05). In the high-risk group, mos was not statistically different for patients undergoing or not undergoing metastasectomy (24.3 months vs. 12.7 months, p = 0.08). Our real-world data analysis of nlr in patients with mcrc confirmed that this biomarker is useful in predicting survival. It also suggests that nlr is an effective tool to choose first-line treatment and to predict the benefit of metastasectomy.

Published
2020

13. Body composition and the cancer patient

Author

I. Fernandes, J. Gramaça, I. Pina, R. Gameiro-dos-Santos, P. Ravasco, and C. Trabulo

Subjects
Oncology, medicine.medical_specialty, Nutrition and Dietetics, business.industry, Endocrinology, Diabetes and Metabolism, Internal medicine, medicine, Cancer, medicine.disease, business, Composition (language)
Published
2021
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18. Aspectos radiológicos de la colitis granulomatosa

Author

J. L. Villavieja Atance, J. I. Pina Leita, and E. J. Freile García

Abstract

La colitis granulomatosa representa las particulares manifestaciones clínicas y radiológicas de la enfermedad de Crohn, con localización en el colon. Aunque puede localizarse en cualquier órgano del aparato digestivo, la afección del colon sigue en importancia a la ileocecal, con idénticas características anatomopatológicas. La radiología es un pilar Fundamental del diagnóstico al establecer signos directos e indirectos de las alteraciones macroscópicas, de su evolución y complicaciones. Presentamos nuestra experiencia en 53 casos de colitis granulomatosa, de los que en 25 existía además afectación ileal. Tres pacientes en fase precoz, presentaron contornos irregulares y pólipos inflamatorios, destacando la importancia del estudio del patrón mucoso. En fase no estenótica con signos evidentes de afectación granulomatosa, se observaron 42 casos con típico patrón en suelo de guijarros y 8 casos en fase no estenótica, con pérdida de relieve mucoso y de haustras. La presencia de fistulizaciones fue poco frecuente; solamente dos casos.

Published
2016
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20. Apartado 12121

Author

MARTIN I PINA, ALVAR, POLLMANN, LEO, VALLEJO, DOMINGO, HUERTAS, MANUEL SÁNCHEZ, AGUILAR, JUAN CARLOS, CORTÉS, JOAQUÍN RUIZ-GIMÉNEZ, and RUIZ, JUAN JOSÉ MORALES

Published
1992

22. Fiber-based heterodyne infrared interferometry: an instrumentation study platform on the way to the proposed Infrared Planet Formation Imager

Author

Miguel I. Pina, Matias Lasen, Ernest A. Michael, Nicolas Ramos, Claudio Yañez, Clemente Pollarolo, Nicolas M. Ortega, Alfredo Rates, Felipe E. Besser, and Mauricio Romero

Subjects
Heterodyne, Physics, business.industry, Infrared, Instrumentation, Near-infrared spectroscopy, Astrophysics::Instrumentation and Methods for Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, law.invention, 010309 optics, Telescope, Interferometry, Optics, Planet, law, 0103 physical sciences, Astronomical interferometer, Astrophysics::Earth and Planetary Astrophysics, 010306 general physics, business, Astrophysics::Galaxy Astrophysics, Remote sensing
Abstract

We present concept and first experimental lab results for a low-cost near-infrared heterodyne interferometer based on commercial 1.55μm fiber components with relative phase-stabilization between both telescopes. After a demonstration with 14”-telescopes, the concept should be upgradable to larger numbers of mid- or large-class telescopes. Given that the employed fiber phase stabilization scheme should enable the operation of long baselines, we discuss the applicability of this concept for long-baseline, high telescope number systems (scalability of the concept) and mid-infrared wavelengths. This could finally result in contributions to the design of the large infrared Planet Formation Imager which is being proposed currently.

Published
2016
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23. Applied Ecology and Human Dimensions in Biological Conservation

Author

Luciano M. Verdade, Maria Carolina Lyra-Jorge, Carlos I. Piña, Luciano M. Verdade, Maria Carolina Lyra-Jorge, and Carlos I. Piña

Subjects
Applied ecology, Biodiversity conservation, Ecosystem management
Abstract

This book provides both the conceptual basis and technological tools that are necessary to identify and solve problems related to biodiversity governance. The authors discuss intriguing evolutionary questions, which involve the sometimes surprising adaptive capacity of certain organisms to dwell in altered and/or changing environments that apparently lost most of their structure and functionality. Space and time heterogeneities are considered in order to understand the patterns of distribution and abundance of species and the various processes that mold them. The book also discusses at which level—from genes to the landscape, including individuals, populations, communities, and ecosystems—men should intervene in nature in order to prevent the loss of biodiversity.

Published
2014

25. Embolismo gaseoso cerebral por accidente de buceo

Author

E. Freile-García, F. Roche-Campo, J.L. Trigeros-Martín, I. López-Jurado, I. Pina-Leita, and J. Mozota-Duarte

Subjects
Axial tomography, business.industry, Anesthesia, Aphasia, Medicine, medicine.symptom, Critical Care and Intensive Care Medicine, business
Abstract

Clinical alterations related to diving accidents are little known perhaps because of its low prevalence. They can be classified as dysbarism-related and non-dysbarism-related according to its relation with pressure changes. We present the case of a diver that showed bradypsychia and transitory aphasia after carrying out an immersion of 30 minutes in duration and 22 meters deep. A left sylvian cerebral infarct was demostrated in cranial computerized axial tomography. Treatment was carried out in a hyperbaric chamber with good clinical evolution. We review with regard to this case the different forms of clinical presentation of dysbarism-related accidents, as well as the usefulness of the hyperbaric chamber in their treatment.

Published
2005
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26. Cap a una ciutadania intercultural. Un tema emergent a la recerca educativa

Author

Bartolomé i Pina, Margarida and Universitat de Barcelona

Subjects
Multicultural education, Democràcia, Civics education, Educació cívica, Democracy, Educació intercultural
Abstract

En este artículo ofrecemos una aproximación al estudio de la ciudadanía intercultural desde la investigación educativa. Para ello, hemos resumido en primer lugar, los nuevos planteamientos de la ciudadanía que fundamentan la investigación realizada por el GREDI en estos últimos años. Nuestro modelo recoge, como rasgos claves de la ciudadanía que pretendemos se desarrolle desde la educación, el hecho de ser, al tiempo, activa y responsable, crítica e intercultural; desarrollada en el ámbito local pero abierta a niveles más amplios. Posteriormente el artículo sintetiza algunas de las investigaciones llevadas a cabo en este campo. La segunda parte de este artículo ofrece un resumen de una de las investigaciones realizadas por el GREDI y que ha permitido diagnosticar los elementos que configuran el concepto y la práctica de la ciudadanía en los jóvenes de 14 a 16 años en Barcelona. Se concluye señalando los elementos significativos que pueden encontrarse en las investigaciones presentadas y que permiten dibujar las líneas de avance para quienes deseen adentrarse en la investigación de esta área temática. ___________________________________________________________________________________________________________________________________________ Cette approche de l’étude de la citoyenneté interculturelle à partir de la recherche éducative débute par une synthèse des nouveaux concepts de citoyenneté élaborés par le GREDI au cours des recherches effectuées ces dernières années. L’auteur défend que c’est l’éducation qui débouchera sur cette nouvelle citoyenneté à la fois active et responsable, critique et interculturelle, appelée à s’exercer au niveau local mais ouverte également sur des horizons plus larges. Après une synthèse des principales recherches effectuées dans ce domaine, la deuxième partie de l’article est consacrée au compte-rendu d’un travail du GREDI ayant permis de diagnostiquer les éléments constituants la théorie et la pratique de la citoyenneté chez les jeunes Barcelonais âgés de 14 à 16 ans. Enfin, un relevé des aspects significatifs des travaux publiés récemment donne des orientations qui peuvent être utiles pour ceux qui souhaiteraient poursuivre des recherches dans ce domaine., This article examines the study of intercultural citizenship within educational research. In so doing, the article first summarises the new approaches to citizenship underpinning the research conducted by the GREDI (Intercultural Education Research Group) in recent years. A model is presented which incorporates, as key traits of the citizenship that we seek to develop through education, the fact of being both active and responsible, critical and intercultural; played out in the local sphere but open to wider levels. The article moves on to summarise some of the research undertaken in this field. The second part offers a précis of one of the studies carried out by the GREDI and which has enabled us to diagnose the elements, both conceptually and in practice, that make up the citizenship of adolescents aged between 14 and 16 years old in Barcelona. The article concludes by identifying the significant elements to be found in the research presented, and which allow the way forward to be mapped out for those seeking to conduct research in this field., En este artículo ofrecemos una aproximación al estudio de la ciudadanía intercultural desde la investigación educativa. Para ello, hemos resumido en primer lugar, los nuevos planteamientos de la ciudadanía que fundamentan la investigación realizada por el GREDI en estos últimos años. Nuestro modelo recoge, como rasgos claves de la ciudadanía que pretendemos se desarrolle desde la educación, el hecho de ser, al tiempo, activa y responsable, crítica e intercultural; desarrollada en el ámbito local pero abierta a niveles más amplios. Posteriormente el artículo sintetiza algunas de las investigaciones llevadas a cabo en este campo. La segunda parte de este artículo ofrece un resumen de una de las investigaciones realizadas por el GREDI y que ha permitido diagnosticar los elementos que configuran el concepto y la práctica de la ciudadanía en los jóvenes de 14 a 16 años en Barcelona. Se concluye señalando los elementos significativos que pueden encontrarse en las investigaciones presentadas y que permiten dibujar las líneas de avance para quienes deseen adentrarse en la investigación de esta área temática.

Published
2012

29. [Persistent primitive trigeminal artery associated to aneurysm of the posterior communicating artery: a case report]

Author

M J, Gimeno Peribáñez, J I, Pina Leita, R, Lasierra Díaz, and B, Carro Alonso

Subjects
Humans, Female, Intracranial Aneurysm, Middle Aged, Subarachnoid Hemorrhage, Magnetic Resonance Imaging
Abstract

We report the case of a patient that presented with an intense headache caused by a subarachnoid hemorrhage. Magnetic resonance angiography demonstrated the existence of an aneurysm of the left posterior communicating artery, as well as of a persistent primitive trigeminal artery.

Published
2007

32. [Heterotopia as the cause of seizures. A case report of familial periependymal heterotopia]

Author

E, Navarro-Cantarero, J I, Pina-Leita, and R, Lasierra-Díaz

Subjects
Brain Diseases, Chromosomes, Human, X, Epilepsy, Filamins, Microfilament Proteins, Brain, Infant, Choristoma, Magnetic Resonance Imaging, Rats, Contractile Proteins, Ependyma, Animals, Humans, Female, Agenesis of Corpus Callosum, Child, Tomography, X-Ray Computed
Abstract

Cortical development disorders constitute a group of entities resulting from an interruption in the development of the central nervous system. Most of them derive from the stoppage of migration, but proliferation and organisation can also be affected. Heterotopia is the most frequent of all migration disorders.We describe three cases of familial periependymal heterotopia consisting in three sisters who, after having seizures in infancy, were submitted to a magnetic resonance (MR) scan that revealed isointense nodules in the cortical grey matter in all the MR sequences. They were diagnosed as having periependymal heterotopia. The existence of a history of early onset seizures in the family of the mother supported the diagnosis of familial heterotopia.Heterotopia is the most frequently occurring anomaly affecting cortical development and, of these, the periependymal form is the most common. Periependymal heterotopia may be determined by sex-linked inheritance (X chromosome). It is considered to be one of the most common congenital disorders in familial and early onset epilepsy. MR is the preferred diagnostic technique, since its high resolution allows it to identify and characterise heterotopias.

Published
2005

33. [Radiological aspects in the diagnosis of Takayasu's arteritis]

Author

B, Carro-Alonso, E, Navarro-Cantarero, C, Castillo-Lario, R, Lasierra-Díaz, J I, Pina-Leita, and I, Ariño-Galve

Subjects
Humans, Female, Middle Aged, Magnetic Resonance Imaging, Takayasu Arteritis, Magnetic Resonance Angiography, Echocardiography, Doppler, Color
Published
2004

34. [Marchiafava-Bignami disease. Four case reports]

Author

M J, Gimeno, R, Lasierra, and J I, Pina

Subjects
Adult, Male, Humans, Neurodegenerative Diseases, Atrophy, Middle Aged, Tomography, X-Ray Computed, Alcohol-Related Disorders, Magnetic Resonance Imaging, Corpus Callosum, Demyelinating Diseases
Published
2002

38. [Scintigraphy with 99MTc-HMPAO labeled leukocytes and computed tomography in the diagnosis of vascular graft infection. A comparative study]

Author

M, Delgado, E, Prats, J L, Benito, M D, Abós, F, García-López, A, Tomás, P, Razola, J I, Pina, and J, Banzo

Subjects
Aged, 80 and over, Male, Prosthesis-Related Infections, Middle Aged, Sensitivity and Specificity, Blood Vessel Prosthesis, Diagnosis, Differential, Technetium Tc 99m Exametazime, Leukocytes, Humans, Radiopharmaceuticals, Radionuclide Imaging, Tomography, X-Ray Computed, Aged
Abstract

The purpose of this work was to compare the results obtained with a scitigraphy using 99mTc-HMPAO labeled leukocyte and a computed tomography (CT) in the diagnosis of vascular graft infection (VGI). We carried out 22 studies with both scintigraphy and CT in 20 patients with vascular grafts with VGI suspicion. One patient had two grafts, thus a total of 23 grafts were analyzed. In addition, 6 control studies were performed. The persistent increase in leukocyte uptake in the graft area was considered as evidence of VGI and the scintigraphy with HMPAO-99mTc labeled leukocytes. For the CT, the presence of perigraft fluid and/or gas collection in the graft bed was also considered to be evidence of VGI. The total number of VGI was 12. The VGI diagnosis was confirmed by culture in all cases. The sensitivity and specificity of the scintigraphy in the diagnosis of VGI was 100%, while the CT has a sensitivity of 58% and specificity of 91%. Five grafts presented pseudoaneurysm in distal aorto-bifemoral graft anastomosis. All theses cases were detected with CT and only one patient with pseudoaneurysms showed scintigraphic evidence of VGI. In addition, both techniques detected two soft tissue infections associated with cutaneous fistulae, one case of abdominal abscess and another of acute diverticulitis. The scintigraphy was also pathologic in one infection of the surgical wound while that the CT was negative. In conclusion, although both techniques are useful to evaluate patients with suspicion of VGI, the scintigraphy with 99m-Tc-HMPAO labeled leukocytes has been shown to be more sensitive than the CT in the assessment of patients with VGI suspicion.

Published
1999

39. Quiste dermoide de la fontanela anterior

Author

J. I. Pina Leita, B. Carro Alonso, R. Lasierra Díaz, and M.aJ. Gimeno Peribáñez

Subjects
business.industry, Pediatrics, Perinatology and Child Health, Medicine, business, Pediatrics, RJ1-570
Published
2008
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41. Presentació

Author

Bartolomé i Pina, Margarida

Published
1995

43. Mecanismes de resistència als [beta]-lactàmics en enterobacteris, 1994-1996

Author

Navarro Risueño, Ferran, Sabaté i Pina, Montse, Navarro Risueño, Ferran, and Sabaté i Pina, Montse

Abstract

Consultable des del TDX, Títol obtingut de la portada digitalitzada, All clinically relevant Enterobacteriaceae strains isolated between 1994 and 1996 without inducible chromosomal b-lactamase, that showed decreased susceptibility to broad-spectrum cephalosporins and/or aztreonam, were selected. The mechanism implicated in the decreased susceptibility was determined by analytical isoelectric focusing, PCR and/or sequenciation. The results obtained showed that the most frequent mechanism implicated in the decreased susceptibility to broad-spectrum cephalosporins and/or aztreonam in E. coli and K. oxytoca was the hyperproduction of the chromosomal b-lactamase, followed by the SHV-1 hyperproduction in E. coli and K. pneumoniae. In our hospital, the incidence of plasmid-mediated extended-spectrum b-lactamases (ESBLs) between 1994 and 1996 was low (0.14%). The b-lactamase that couldn't be identified by the techniques previously described, was characterised by conjugation studies, clonation, and sequenciation experiments, allowing us to describe a new b-lactamase, CTX-M-9, that was the most frequent ESBL detected in our laboratory. The CTX-M-type b-lactamases has been described in various species of the family Enterobacteriaceae in geographically and temporally widely distant areas, most of them being plasmid-encoded. To know more about the dissemination of these enzymes around the world, we decided to study the environment of blaCTX-M-9. This study suggested us that blaCTX-M-9 is contained in a new complex integron, In60. This integron has the common 5'-CS and 3'-CS conserved sequences of class 1 integron and two gene cassettes encoding for a dihydrofolate reductase (dfrA16) and aminoglycoside-adenylytransferase (aadA2). Downstream of the first sul1 gene is present the orf513. Following this region there is the blaCTX-M-9 and an orf3-like region showing both about 80% identity with blaKLUA-1 and orf3 of K. ascorbata, respectively. Downstream of the orf3-like region, a new insertion sequence designated IS3000, is found. This IS is flanked

Published
2002

44. [Percutaneous and surgical gastrostomies: our clinical experience in enteral nutrition]

Author

A, Sanz, M A, de Gregorio, E, Civeira, A, Jiménez, J I, Pina, and S, Celaya

Subjects
Gastrostomy, Male, Radiography, Enteral Nutrition, Time Factors, Evaluation Studies as Topic, Stomach, Humans, Female, Middle Aged, Aged
Abstract

Percutaneous gastrostomy (PG) was performed on 18 patients and 11 patients were subjected to surgical gastrostomy (SG) in the HCU of Zaragoza from October 1990 to November 1991. Involvement of the high digestive tract was the most common finding: 11 patients had CA of the oesophagus and stomach, 2 suffered from extrinsic pressure of the oesophagus due to metastatic adenopathy of a lung and breast tumour and 9 patients had CA of the larynx with total dysphagia. Another less common indication in our series, although still of great importance, was a severe involvement of the CMS, which made oral nutrition impossible due to functional dysphagia. Due to the long-term nature of this pathology, feeding by nasogastric tube was not considered. This was the case of 4 patients. The duration of enteral nutritional in the patients' home was 112.8 +/- 61 days with PG and 37 +/- 26 days with SG (p: 0.007). The incidence of complications was 33% in PG and 73% in SG, and for both techniques, the most common complication was blockage of the tube. Percutaneous gastrostomy is a simple technique, with no surgical risks involved, but with the benefits of traditional surgical techniques which, despite the small number of cases recorded, has very few complications both with regard to placing and afterwards, and also enables the patient to receive nutrients earlier than would be the case with traditional surgical techniques during prolonged periods at the patient's home.

Published
1992

45. Enfermedad de Marchiafava-Bignami. A propósito de cuatro casos

Author

J I Pina, M J Gimeno, and Lasierra R

Subjects
medicine.medical_specialty, medicine.diagnostic_test, X ray computed, business.industry, Medicine, Magnetic resonance imaging, Neurology (clinical), General Medicine, Radiology, Marchiafava–Bignami disease, business, medicine.disease
Published
2002
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47. Construcción de un electrodo selectivo a cimetidina

Author

M Troconis, Jorge Palmar, Lisbeth Rolon, L Araujo, A Prieto, and I Piña

Subjects
Cimetidina, electrodo selectivo, membrana heterogénea, potenciometría directa., Engineering (General). Civil engineering (General), TA1-2040, Technology (General), T1-995
Abstract

En este trabajo, se construyó y evaluó la respuestaelectroquímica de un electrodo de membran aheterogénea selectivo a cimetidina incorporando un complejo de par iónicocimetidina - ácidofosfotúngstico (CMT-AFT) como material electroactivo, dibutilftalato (DBP) comoplastificante y policloruro de vinilo (PVC) comosoporte. Se optimizaron los parámetros que afectan el funcionamiento del electrodo, tales como: composición de la membrana, concentración de la disolución interna y pH. El electrodo mostró una respuesta rápida y estable con un intervalo lineal desde 1,00x10-4 hasta 1,00x10-1 M encimetidina al serutilizadoen un rango de pH entre 2,73 – 5,00 unidades, unapendiente de 56,63 ± 0,06 mV pordécada y un límite de detección de 3,98x10-5 M a 25,00 ± 1,00 ° C. El electrodoexhibióunabuenaselectividad para la cimetidina con respecto a un número de ionesinorgánicoscomunes. El electrodo de membranafueaplicadoen la determinación de cimetidina en formulacione sfarmacéuticas mediante potenciometría directa obteniéndose resultados que no difieren significativamente con los declarados por las empresasfarmacéuticas.

Published
2019

49. Study of modified lead titanate ceramics by Auger electron spectroscopy

Author

J. L. Sacedon, J. I. Pina, and Lorena Pardo

Subjects
Auger electron spectroscopy, Surface rupture, Materials science, Mechanical Engineering, Fracture (mineralogy), Mineralogy, chemistry.chemical_compound, chemistry, Mechanics of Materials, Sputtering, visual_art, visual_art.visual_art_medium, General Materials Science, Ceramic, Lead titanate, Composite material, Electroceramics, High potential
Abstract

Calcium-modified lead titanate extruded and isostatically pressed ceramics have been studied, for the first time, by depth profile Auger electron spectroscopy. Our results show the high potential of the technique to determine the composition of inter- and intragranular fracture surfaces. Two different mechanisms of lead enrichment of the fracture surfaces are observed. Finally, the results are compared with a model of preferential sputtering of the different oxides.

Published
1988
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50. Propranolol in the treatment of renin-mediated hypertension

Author

Jorge I. Pina, Veeraiah C. Karumanchi, and Budh D. Bhagat

Subjects
Pharmacology, medicine.medical_specialty, Sympathetic nervous system, Sympathetic Nervous System, Physiology, business.industry, General Medicine, Propranolol, Juxtaglomerular apparatus, Juxtaglomerular Apparatus, Receptors, Adrenergic, medicine.anatomical_structure, Endocrinology, Text mining, Physiology (medical), Internal medicine, Hypertension, Renin, Renin–angiotensin system, medicine, Humans, business, medicine.drug
Published
1980
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