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3 results on '"I E Gerbek"'

1. Age-related characteristics of the efficacy of different glucocorticosteroids in the therapy of acute lymphoblastic leukemia

Author

A I Karachunsky, Yu V Rumyantseva, S N Lagoiko, C Bührer, G Tallen, O V Aleinikova, O I Bydanov, N V Korepanova, L V Baidun, T V Nasedkina, A Von Stackelberg, G A Novichkova, A A Maschan, D V Litvinov, N I Ponomareva, K L Kondratchik, E G Mansurova, L G Fechina, O V Streneva, N B Yudina, G R Sharapova, A V Shamardina, I E Gerbek, A P Shapochnik, A G Rumyantsev, and G Henze

Subjects
acute lymphoblastic leukemia, children, therapy, glucocorticosteroids, dexamethasone, prednisolone, induction, Medicine
Abstract

Aim. To determine predictors for decision-making on a differential approach to choosing glucocorticosteroids (GCS) for children and adolescents with acute lymphoblastic leukemia (ALL). Subjects and methods. The analysis covered 1064 primary patients aged to 1 to 18 years with ALL who had been registered at the clinics of Russia and Belorussia in April 2002 to November 2006. Before induction therapy, the patients were randomized into a dexamethasone (DEXA) 6 mg/m2 group (n=539) and a methylprednisolone (MePRED) 60 mg/m2 one (n=525). Results. The entire group showed no statistically significant differences in survival rates between the patients receiving DEXA or MePRED. However, an analysis of age groups revealed the benefits of DEXA in children younger than 14 years (the event-free survival (EFS) was 76±2 and 71±2%, respectively (p=0.048); the overall survival (OS) was 81±2 and 77±2%, respectively (р=0.046); therapy-induced mortality was 6.4% (DEXA) and11.1% (MePRED) (р=0.014); the rate of isolated extramedullary relapses was 1.5% (DEXA) and 4.4% (MePRED) ( р=0.009). At the same time, EFS and OS in 14-to-18-year-old adolescents were statistically significantly higher than in those who used MePRED (EFS, 65±6 and 52±6%, respectively (р=0.087); OS, 72±6 and 61±6%, respectively; (р=0.17). Conclusion. The findings suggest that it is possible that the choice of a GCS for ALL therapy must be also based on a patient’s age. There is a need for further studies of this matter in prospective randomized multicenter trials in children and adolescents.

Published
2015

2. A pilot screening of prevalence of atopic states and opisthorchosis and their relationship in people of Tomsk Oblast

Author

I. E. Gerbek, Maxim B. Freidin, Ludmila M. Ogorodova, A. E. Sazonov, O. S. Fedorova, N. Yu. Lebedeva, and N. A. Cherevko

Subjects
Adult, Hypersensitivity, Immediate, Male, Rural Population, Adolescent, Urban Population, Population, Antibodies, Helminth, Pilot Projects, Negative association, Disease, Opisthorchiasis, Russia, Atopy, Environmental protection, Rural people, Environmental health, Opisthorchis, Prevalence, medicine, Animals, Humans, Opisthorchis felineus, Child, education, Skin Tests, education.field_of_study, General Veterinary, biology, business.industry, General Medicine, Middle Aged, biology.organism_classification, medicine.disease, Infectious Diseases, Insect Science, Female, Parasitology, business
Abstract

The study was aimed to estimate the relationship between the prevalence of allergic disease and helminth invasion by the trematode Opisthorchis felineus in rural and urban populations of Tomsk Oblast (West Siberia, Russia). Two hundred and one people from Kargasok village of Tomsk Oblast and 196 from the city of Tomsk were screened for the presence of atopy and O. felineus invasion. Opisthorchosis was found in 66 participants (32.8%) from Kargasok and in 22 people (11.2%) from Tomsk. Atopic diseases were more common in the urban population than in the rural: 52.8 and 31.4%, respectively. Positive skin-prick tests were significantly higher in the urban population than in rural people: 83.2 vs 24.4%, respectively. It was found that in the city, the presence of antibodies to O. felineus negatively correlates with the atopic sensitization by skin-prick tests. However, in the village, opisthorchosis was positively associated with atopic diseases. The data obtained confirm the negative association of rural lifestyle and atopic diseases prevalence and indicate that O. felineus invasion might be a modifying factor of this relationship in Tomsk Oblast.

Published
2007
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3. Study of occurrence and correlation between allergic diseases and opisthorchiasis in the population of the Tomsk Region

Author

T. V. Perevozchikova, N. A. Cherevko, Maxim B. Freidin, Ye. A. Fait, O. S. Fedorova, I. E. Gerbek, Ludmila M. Ogorodova, Ye. Yu. Bragina, A. E. Sazonov, N. Yu. Lebedeva, and A. A. Roudko

Subjects
allergic diseases, education.field_of_study, business.industry, эпидемиология, Population, specific sensitization, описторхозная инвазия, medicine.disease, opisthorchiasis, Opisthorchiasis, аллергическая патология, Immunology, специфическая сенсибилизация, medicine, Medicine, Molecular Medicine, epidemiology, business, education
Abstract

The aim was to estimate the epidemiological and pathogenetic correlation between allergic diseases and opisthorchiasis in the population of Tomsk and the Tomsk Region. The program was a cross-sectional epidemiological snap study based on two samples: village inhabitants ( n = 201; mean age 12,1 ± 3,4) and Tomsk inhabitants ( n = 196; mean age 30,16 ± 12,86). The epidemiological, clinical, parasitological, allergological, immunological, and statistical methods were used in the study. It has been found that allergic diseases affected about 40.9% of village patients with opisthorchiasis and 26,1% people without parasites ( р < 0.05). For Tomsk inhabitants, this proportion was 54,5 and 52,6%.

Published
2006
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