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3. Short-term outcomes of extremely low birth weight infants in a tertiary neonatal intensive care unit in Türkiye.

Author

Kavurt, Sumru, Baş, Ahmet Yağmur, İşleyen, Fatih, Tosun, Mehtap Durukan, Işık, Dilek Ulubaş, and Demirel, Nihal

Abstract

Background. Advances in neonatal care have led to increased survival of extremely preterm infants. Extremely low-birth-weight (ELBW) infants, defined as infants weighing less than 1000 g at birth, constitute a significant portion of neonatal intensive care unit (NICU) patients. The aim of this study is to determine the mortality and short-term morbidities of ELBW infants and assess the risk factors related to mortality. Methods. The medical records of ELBW neonates hospitalized in the NICU of a tertiary-level hospital between January 2017 and December 2021 were evaluated retrospectively. Results. 616 ELBW (289 females and 327 males) infants were admitted to the NICU during the study period. Mean birth weight (BW) and gestational age (GA) for the total cohort were 725 ± 134 g (range 420-980 g) and 26.3 ± 2.1 weeks (range 22-31), respectively. The rate of survival to discharge was 54.5% (336/616) [33% for the infants with ≤750 g BW, 76% for the infants with 750-1000 g BW], and 45.2% of survived infants had no major neonatal morbidity at discharge. Independent risk factors for mortality of ELBW infants were asphyxia at birth, birth weight, respiratory distress syndrome, pulmonary hemorrhage, severe intraventricular hemorrhage, and meningitis. Conclusions. The incidence of mortality and morbidity was very high in ELBW infants, particularly for neonates born weighing less than 750 g in our study. We suggest that preventive and more effective treatment strategies are needed for improved outcomes in ELBW infants. [ABSTRACT FROM AUTHOR]

Published
2023
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4. Early neonatal outcomes of very-low-birth-weight infants in Turkey: a prospective multicenter study of the Turkish Neonatal Society

Author

Gürsoy, Tuğba (ORCID 0000-0002-6084-4067 & YÖK ID 214691), Koç, Esin; Demirel, Nihal; Baş, Ahmet Yağmur; Işık, Dilek Ulubaş; Hirfanoğlu, İbrahim Murat; Tunc, Turan; Sarı, Fatma Nur; Karatekin, Güner; Özdemir, Ramazan; Altunhan, Hüseyin; Çetinkaya, Merih; Özcan, Beyza; Özkiraz, Servet; Çalkavur, Sebnem; Tekgündüz, Kadir Şerafettin; Taştekin, Ayhan; Özlü, Ferda; Özyurt, Banu Mutlu; Özdemir, Ahmet; Çetinkaya, Bilin; Demirelli, Yaşar; Köklü, Esad; Çelik, Ülker; Tarakçı, Nuriye; Armangil, Didem; Okulu, Emel; Narter, Fatma; Mutlu, Birgul; Mert, Mustafa Kurthan; Bülbül, Ali; Asker, Hüseyin Selim; Uygur, ÖzgÜn; Uslu, İlker Sait; Ertuğrul, Sabahattin; Aydemir, Cumhur; Çelik, Hasan Tolga; Küçüktaşçı, Kazım; Arslan, Selda; Ergin, Hacer; Zenciroğlu, Aysegül; Yurttutan, Sadık; Orman, Ayşen; Tuncer, Oğuz; Yaşa, Beril; Acunas, Betül; Takci, Şahin; Gökmen, Zeynel; Özkan, Hilal; Cömert, Serdar; Üstün, Nuran; Mutlu, Mehmet; Bayraktar, Bilge Tanyeri; Bilgin, Leyla; Tuzun, Funda; Aydemir, Özge; Akdağ, Arzu; Memisoğlu, Aslı; Can, Emrah; Terek, Demet; Beken, Serdar; Turan, Özden; Güzoğlu, Nilüfer; Örs, Rahmi; Kale, Yusuf; Hekimoğlu, Berna; Aylanc, Hakan; Eroğlu, Funda; Şahin, Suzan; Konak, Murat; Sarıcı, Dilek; Kılıç, İlknur; Hakan, Nilay, School of Medicine, Gürsoy, Tuğba (ORCID 0000-0002-6084-4067 & YÖK ID 214691), Koç, Esin; Demirel, Nihal; Baş, Ahmet Yağmur; Işık, Dilek Ulubaş; Hirfanoğlu, İbrahim Murat; Tunc, Turan; Sarı, Fatma Nur; Karatekin, Güner; Özdemir, Ramazan; Altunhan, Hüseyin; Çetinkaya, Merih; Özcan, Beyza; Özkiraz, Servet; Çalkavur, Sebnem; Tekgündüz, Kadir Şerafettin; Taştekin, Ayhan; Özlü, Ferda; Özyurt, Banu Mutlu; Özdemir, Ahmet; Çetinkaya, Bilin; Demirelli, Yaşar; Köklü, Esad; Çelik, Ülker; Tarakçı, Nuriye; Armangil, Didem; Okulu, Emel; Narter, Fatma; Mutlu, Birgul; Mert, Mustafa Kurthan; Bülbül, Ali; Asker, Hüseyin Selim; Uygur, ÖzgÜn; Uslu, İlker Sait; Ertuğrul, Sabahattin; Aydemir, Cumhur; Çelik, Hasan Tolga; Küçüktaşçı, Kazım; Arslan, Selda; Ergin, Hacer; Zenciroğlu, Aysegül; Yurttutan, Sadık; Orman, Ayşen; Tuncer, Oğuz; Yaşa, Beril; Acunas, Betül; Takci, Şahin; Gökmen, Zeynel; Özkan, Hilal; Cömert, Serdar; Üstün, Nuran; Mutlu, Mehmet; Bayraktar, Bilge Tanyeri; Bilgin, Leyla; Tuzun, Funda; Aydemir, Özge; Akdağ, Arzu; Memisoğlu, Aslı; Can, Emrah; Terek, Demet; Beken, Serdar; Turan, Özden; Güzoğlu, Nilüfer; Örs, Rahmi; Kale, Yusuf; Hekimoğlu, Berna; Aylanc, Hakan; Eroğlu, Funda; Şahin, Suzan; Konak, Murat; Sarıcı, Dilek; Kılıç, İlknur; Hakan, Nilay, and School of Medicine

Abstract

Objective: to investigate the early neonatal outcomes of very-low-birth-weight (VLBW) infants discharged home from neonatal intensive care units (NICUs) in Turkey. Material and methods: a prospective cohort study was performed between April 1, 2016 and April 30, 2017. The study included VLBW infants admitted to level III NICUs. Perinatal and neonatal data of all infants born with a birth weight of.1500 g were collected for infants who survived. Results: data from 69 NICUs were obtained. The mean birth weight and gestational age were 1137 +/- 245 g and 29 +/- 2.4 weeks, respectively. During the study period, 78% of VLBW infants survived to discharge and 48% of survived infants had no major neonatal morbidity. VLBW infants who survived were evaluated in terms of major morbidities: bronchopulmonary dysplasia was detected in 23.7% of infants, necrotizing enterocolitis in 9.1%, blood culture proven late-onset sepsis (LOS) in 21.1%, blood culture negative LOS in 21.3%, severe intraventricular hemorrhage in 5.4% and severe retinopathy of prematurity in 11.1%. Hemodynamically significant patent ductus arteriosus was diagnosed in 24.8% of infants. Antenatal steroids were administered to 42.9% of mothers. Conclusion: the present investigation is the first multicenter study to include epidemiological information on VLBW infants in Turkey. Morbidity rate in VLBW infants is a serious concern and higher than those in developed countries. Implementation of oxygen therapy with appropriate monitoring, better antenatal and neonatal care and control of sepsis may reduce the prevalence of neonatal morbidities. Therefore, monitoring standards of neonatal care and implementing quality improvement projects across the country are essential for improving neonatal outcomes in Turkish NICUs., Turkish Neonatal Society

Published
2019

5. Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units

Author

Uludağ, Günay (ORCID & YÖK ID 175586); Gürsoy, Tuğba (ORCID 0000-0002-6084-4067 & YÖK ID 214691), Baş, Ahmet Yağmur; Demirel, Nihal; Koç, Esin; Işık, Dilek Ulubaş; Hirfanoğlu, İbrahim Murat; Tunç, Turan; Sarı, Fatma Nur; Karatekin, Güner; Köklü, Esad; Altunhan, Hüseyin; Turgut, Hatice; Narter, Fatma; Tarakçı, Nuriye; Tekgündüz, Kadir Şerafettin; Özkiraz, Servet; Aydemir, Cumhur; Özdemir, Ahmet; Çetinkaya, Bilin; Kazancı, Ebru; Taştekin, Ayhan; Calkavur, Şebnem; Özyurt, Banu Mutlu; Demirelli, Yaşar; Asker, Hüseyin Selim; Mutlu, Birgul; Uygur, Özgün; Özkan, Hilal; Armangil, Didem; Özlü, Ferda; Mert, Mustafa Kurthan; Ergin, Hacer; Özcan, Beyza; Baş, Evrim Kıray; Okulu, Emel; Acunas, Betül; Çelik, Ülker; Uslu, Sait İlker; Mutlu, Mehmet; Demir, Nihat; Eroğlu, Funda; Gökmen, Zeynel; Beken, Serdar; Bayraktar, Bilge Tanyeri; Hakan, Nilay; Küçüktaşçı, Kazım; Orman, Ayşen; Cömert, Serdar; Ertuğrul, Sabahattin; Üstün, Nuran; Şahin, Özlem; Terek, Demet; Kale, Yusuf; Konak, Murat; Yurttutan, Sadık; Aydemir, Özge; Zenciroğlu, Aysegül; Sarıcı, Dilek; Güzoğlu, Nilüfer; Hamilçıkan, Şahin; Tüzün, Funda; Örs, Rahmi; Arslan, Selda; Akdağ, Arzu; Memişoğlu, Aslı; Yasa, Beril; Hekimoğlu, Berna; Turan, Özden; Aylanc, Hakan; Takçı, Şahin; Çelik, Tolga; Şahin, Suzan; Kılıç, İlknur; Kara, Caner; Tunay, Zuhal Özen; Çelik, Gökhan; Gözen, İbrahim; Satırtav, Günhal; Polat, Nihat; Oral, Ayşe Yeşim; Tokgöz, Mine; Keleş, Sadullah; Bilgin, Burak; Uğurbaş, Silay Cantürk; Karaca, Çağatay; Keşkek, Nedime Şahinoğlu; Ekinci, Dilbade Yıldız; Balcı, Özlem; Altan, Emir Volkan; Bakbak, Sevda; Ceylan, Nihan Aksu; Kimyon, Sabit; Alyamaç, Günay; Türe, Gamze; Yıldız, Meral; Çalış, Feyza; Sızmaz, Selçuk; Sukgen, Emine; Çetin, Ebru Nevin; Özçimen, Muammer; Demir, Semra Tiryaki; Atila, Huban; Özal, Altan; Tufaner, Gökhan; Yücel, Özlem Eski; Kola, Mehmet; Seven, Erbil; Özdek, Şengül; Durukan, Ali Hakan; Kal, Ali; Çelebi, Ali Riza Cenk; Koytak, İbrahim Arif; Alaçamlı, Göksu; Esme, Arif; Çatak, Onur; Perente, İrfan; Şahin, Alparslan; Akçakaya, Aylin Ardagil; Kıray, Gülünay; Nalçacı, Serhat; Aksoy, Ümit; Bakbak, Ber, School of Medicine, Department of Internal Medicine, Uludağ, Günay (ORCID & YÖK ID 175586); Gürsoy, Tuğba (ORCID 0000-0002-6084-4067 & YÖK ID 214691), Baş, Ahmet Yağmur; Demirel, Nihal; Koç, Esin; Işık, Dilek Ulubaş; Hirfanoğlu, İbrahim Murat; Tunç, Turan; Sarı, Fatma Nur; Karatekin, Güner; Köklü, Esad; Altunhan, Hüseyin; Turgut, Hatice; Narter, Fatma; Tarakçı, Nuriye; Tekgündüz, Kadir Şerafettin; Özkiraz, Servet; Aydemir, Cumhur; Özdemir, Ahmet; Çetinkaya, Bilin; Kazancı, Ebru; Taştekin, Ayhan; Calkavur, Şebnem; Özyurt, Banu Mutlu; Demirelli, Yaşar; Asker, Hüseyin Selim; Mutlu, Birgul; Uygur, Özgün; Özkan, Hilal; Armangil, Didem; Özlü, Ferda; Mert, Mustafa Kurthan; Ergin, Hacer; Özcan, Beyza; Baş, Evrim Kıray; Okulu, Emel; Acunas, Betül; Çelik, Ülker; Uslu, Sait İlker; Mutlu, Mehmet; Demir, Nihat; Eroğlu, Funda; Gökmen, Zeynel; Beken, Serdar; Bayraktar, Bilge Tanyeri; Hakan, Nilay; Küçüktaşçı, Kazım; Orman, Ayşen; Cömert, Serdar; Ertuğrul, Sabahattin; Üstün, Nuran; Şahin, Özlem; Terek, Demet; Kale, Yusuf; Konak, Murat; Yurttutan, Sadık; Aydemir, Özge; Zenciroğlu, Aysegül; Sarıcı, Dilek; Güzoğlu, Nilüfer; Hamilçıkan, Şahin; Tüzün, Funda; Örs, Rahmi; Arslan, Selda; Akdağ, Arzu; Memişoğlu, Aslı; Yasa, Beril; Hekimoğlu, Berna; Turan, Özden; Aylanc, Hakan; Takçı, Şahin; Çelik, Tolga; Şahin, Suzan; Kılıç, İlknur; Kara, Caner; Tunay, Zuhal Özen; Çelik, Gökhan; Gözen, İbrahim; Satırtav, Günhal; Polat, Nihat; Oral, Ayşe Yeşim; Tokgöz, Mine; Keleş, Sadullah; Bilgin, Burak; Uğurbaş, Silay Cantürk; Karaca, Çağatay; Keşkek, Nedime Şahinoğlu; Ekinci, Dilbade Yıldız; Balcı, Özlem; Altan, Emir Volkan; Bakbak, Sevda; Ceylan, Nihan Aksu; Kimyon, Sabit; Alyamaç, Günay; Türe, Gamze; Yıldız, Meral; Çalış, Feyza; Sızmaz, Selçuk; Sukgen, Emine; Çetin, Ebru Nevin; Özçimen, Muammer; Demir, Semra Tiryaki; Atila, Huban; Özal, Altan; Tufaner, Gökhan; Yücel, Özlem Eski; Kola, Mehmet; Seven, Erbil; Özdek, Şengül; Durukan, Ali Hakan; Kal, Ali; Çelebi, Ali Riza Cenk; Koytak, İbrahim Arif; Alaçamlı, Göksu; Esme, Arif; Çatak, Onur; Perente, İrfan; Şahin, Alparslan; Akçakaya, Aylin Ardagil; Kıray, Gülünay; Nalçacı, Serhat; Aksoy, Ümit; Bakbak, Ber, School of Medicine, and Department of Internal Medicine

Abstract

Background to evaluate the prevalence, risk factors and treatment of retinopathy of prematurity (ROP) in Turkey and to establish screening criteria for this condition. Methods: a prospective cohort study (TR-ROP) was performed between 1 April 2016 and 30 April 2017 in 69 neonatal intensive care units (NICUs). Infants with a birth weight (BW)=1500 g or gestational age (GA)<= 32 weeks and those with a BW> 1500 g or GA> 32 weeks with an unstable clinical course were included in the study. Predictors for the development of ROP were determined by logistic regression analyses. Results: the TR-ROP study included 6115 infants: 4964 (81%) with a GA <= 32 weeks and 1151 (19%) with a GA>32 weeks. Overall, 27% had any stage of ROP and 6.7% had severe ROP. A lower BW, smaller GA, total days on oxygen, late-onset sepsis, frequency of red blood cell transfusions and relative weight gain were identified as independent risk factors for severe ROP in infants with a BW=1500 g. Of all infants, 414 needed treatment and 395 (95.4%) of the treated infants had a BW <= 1500 g. Sixty-six (16%) of the treated infants did not fulfil the Early Treatment for Retinopathy of Prematurity requirements for treatment. Conclusions: screening of infants with a GA <= 34 weeks or a BW<1700 g appears to be appropriate in Turkey. Monitoring standards of neonatal care and conducting quality improvement projects across the country are recommended to improve neonatal outcomes in Turkish NICUs., NA

Published
2018

6. Effect of birth weight on retinopathy of prematurity in discordant twin pairs.

Author

Petriçli, İkbal, Kara, Caner, Işık, Dilek, Demirel, Nihal, Baş, Ahmet, Petricli, İkbal Seza, Işık, Dilek Ulubaş, and Baş, Ahmet Yağmur

Subjects
RETROLENTAL fibroplasia, BIRTH weight, GESTATIONAL age, REGRESSION analysis, ODDS ratio
Abstract

Purpose: Since twin pairs with discordance have equal gestational age (GA), discordant twins may constitute an appropriate group to investigate the specific effect that birth weight (BW) has on the development of retinopathy of prematurity (ROP). The present study aims to investigate the effect of BW on any and severe stages of ROP development in twin pairs.Methods: Fifty-two discordant twin pairs (104 preterms) born ≤32 gestational weeks, who were diagnosed with a minimum of 18% discordance between their BWs, were retrospectively analyzed. Twin pairs were separated into two groups based on the BW of each pair. The rate of any stage of ROP, Type 1 ROP, and perinatal risk factors were compared statistically among twin pairs.Results: The rate of any stage of ROP and Type 1 ROP was 24.0% and 4.8% in the whole group, respectively. A statistically significant difference was shown between lower and higher BW groups at any stage of ROP development (34.6% vs. 13.4%, P = 0.02). However, no difference was observed in Type 1 ROP development (7.7% vs. 1.9%, P = 0.17). No significant differences were found between twin pairs regarding neonatal morbidities. The number of small GA (SGA) infants in the smaller twin group was statistically higher than larger group and regression analysis showed that being SGA had significant correlation with any stage of ROP (odds ratio: 4.98, P = 0.02).Conclusion: This study showed that BW serves an effective role at any stage of ROP development in discordant twin pairs; however, no significant difference in terms of Type 1 ROP. [ABSTRACT FROM AUTHOR]

Published
2019
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7. Non-immune Hydrops Fetalis: Retrospective Evaluation of Pathophysiological Mechanisms.

Author

Unal, Sezin, Işık, Dilek Ulubaş, Demirel, Nihal, Özcan, Beyza, Çelik, İstemi Han, and Baş, Ahmet Yağmur

Subjects
*HYDROPS fetalis, *PATHOLOGICAL physiology, *RETROSPECTIVE studies
Abstract

Objective: Nonimmune hydrops fetalis (NIHF) is associated with abnormal fluid collections in fetal soft tissues and serous cavities due to nonimmunologic causes, it should be considered as a symptom, rather than a disorder. We aimed to investigate etiology and pathophysiology in cases with NIHF during a four-year time period. Methods: Eleven live-born infants with NIHF were evaluated retrospectively. Demographic data, laboratory values, and results of specified tests were recorded. Etiology and pathophysiological mechanisms were established. Results: The mean gestational age at birth was 32.8±2.6 weeks and the mean birth weight was 25451809 grams. All cases presented with edema and ascites. Chromosomal disorders (5/11) were the leading etiology. Pathophysiological mechanisms were observed as fetal hypotonia, fetal hypoxia, lymphatic disorders, hypoalbuminemia, early closure of ductus arteriosus, anemia, and right-sided heart failure. Mortality was 72%. Conclusion: In the presented study NIHF occurred as a symptom which was presented in various conditions based on different mechanisms. Evaluations made in infants with NIHF should aim both diagnosis of the condition as well as finding out the underlying pathophysiological mechanisms. Mortality rate in infants with NIHF is high even though the improvements in neonatal care. [ABSTRACT FROM AUTHOR]

Published
2017
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8. Case Series of Congenital Cytomegalovirus Infection in Neonatal Period.

Author

Işık, Dilek Ulubaş, Özcan, Beyza, Demirel, Nihal, Ünal, Sezin, Çelik, İstemi Han, and Baş, Ahmet Yağmur

Subjects
*CYTOMEGALOVIRUS diseases, *NEONATAL diseases, *FETAL growth retardation, *GENETICS
Abstract

Objective: Cytomegalovirus (CMV) is one of the most common cause of congenital infections in the newborn. CMV infection is a multisystem disease, which symptomatic infants generally present with intrauterine growth restriction, hepatosplenomegaly, cholestasis, rash, thrombocytopenia, and microcephaly. Methods: Retrospective chart review was performed for newborns who were diagnosed with congenital CMV infection at tertiary neonatal intensive care unit (NICU) in Turkey, between October 2012 and January 2015. Results: We identified eight cases with congenital CMV infection with an incidence of 0.15% among admitted neonates. Mean gestational age and birth weight of cases were 32.6 (±4.2) weeks and 1591 (±681) g respectively. Six (75%) cases were premature. The symptoms at presentation were as follows; thrombocytopenia, cholestatic hepatitis, blue-berry muffin rash, intracranial calcification, microcephaly, pneumonia, and bilateral cataract. Five cases were treated with ganciclovir. Three of them died in follow-up. Conclusion: Congenital CMV infection is an important cause of neonatal morbidity and mortality. Physicians should be aware of the preventive measures and postnatal interventions of congenital CMV infection. [ABSTRACT FROM AUTHOR]

Published
2018
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9. Görme fonksiyonunu bozan kutenöz hemanjiomun prematüre bir bebekte propranolol ile tedavisi.

Author

Kale, Yusuf, Işık, Dilek Ulubaş, Yücel, Hüsniye, Emir, Suna, Aydemir, Özge, Baş, Ahmet Yağmur, and Demirel, Nihal

Subjects
*HEMANGIOMAS, *PREMATURE infant diseases, *AMBLYOPIA, *PROPRANOLOL, *THERAPEUTICS, EYELID tumors
Abstract

Hemangiomas are the most common benign tumors of the eyelids in infancy. They may arise as small isolated lesions or large lesions affecting visual function. In most cases, treatment is not needed. However, if the lesion leads to functional impairment or ulcerates, treatment is necessary. Herein, we present the case of a preterm infant with rapidly growing cutaneous hemangioma of the eyelid with a potential risk of amblyopia, which was successfully treated with propranolol. [ABSTRACT FROM AUTHOR]

Published
2013

11. Early neonatal outcomes of very-low-birthweight infants in Turkey: A prospective multicenter study of the Turkish Neonatal Society

Author

Hüseyin Selim Asker, Emrah Can, Cumhur Aydemir, Betül Acunaş, Ali Bulbul, Turan Tunc, Kadir Şerafettin Tekgündüz, Hasan Tolga Çelik, Şahin Takcı, Ramazan Ozdemir, Ahmet Ozdemir, Mehmet Mutlu, Ferda Özlü, Yasar Demirelli, Beyza Ozcan, Rahmi Ors, Fatma Nur Sari, Ilknur Kilic, Guner Karatekin, Dilek Ulubas Isik, Banu Mutlu Özyurt, Berna Hekimoğlu, Sabahattin Ertuğrul, Murat Konak, Selda Arslan, Nuriye Tarakci, Ozgun Uygur, Serdar Cömert, Sadık Yurttutan, Kazim Kucuktasci, Emel Okulu, Arzu Akdag, Nilay Hakan, Nilüfer Güzoğlu, Tugba Gursoy, Hakan Aylanç, Şebnem Çalkavur, Asli Memisoglu, Ayşegül Zenciroğlu, Bilin Cetinkaya, Serdar Beken, Ozge Aydemir, Hacer Ergin, Ibrahim Murat Hirfanoglu, Yusuf Kale, Didem Armangil, Suzan Sahin, Bilge Tanyeri Bayraktar, Özden Turan, Huseyin Altunhan, Servet Ozkiraz, İlker Uslu, Nihal Demirel, Funda Eroglu, Zeynel Gokmen, Aysen Orman, Leyla Bilgin, Esin Koç, Beril Yasa, Demet Terek, Funda Tuzun, Esad Koklu, Nuran Üstün, Birgul Mutlu, Ahmet Yagmur Bas, Merih Cetinkaya, Hilal Özkan, Fatma Narter, Mustafa Kurthan Mert, Ayhan Tastekin, Ulker Celik, Dilek Sarici, Oğuz Tuncer, KOÇ E., DEMİREL N., BAŞ A. Y., Isik D. U., HIRFANOĞLU İ. M., Tunc T., Sari F. N., Karatekin G., ÖZDEMİR R., Altunhan H., et al., Ege Üniversitesi, MÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Hakan, Nilay, Dicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı, Ertuǧrul, Sabahattin, Selçuk Üniversitesi, OMÜ, Gürsoy, Tuğba (ORCID 0000-0002-6084-4067 & YÖK ID 214691), Koç, Esin, Demirel, Nihal, Baş, Ahmet Yağmur, Işık, Dilek Ulubaş, Hirfanoğlu, İbrahim Murat, Tunc, Turan, Sarı, Fatma Nur, Karatekin, Güner, Özdemir, Ramazan, Altunhan, Hüseyin, Çetinkaya, Merih, Özcan, Beyza, Özkiraz, Servet, Çalkavur, Sebnem, Tekgündüz, Kadir Şerafettin, Taştekin, Ayhan, Özlü, Ferda, Özyurt, Banu Mutlu, Özdemir, Ahmet, Çetinkaya, Bilin, Demirelli, Yaşar, Köklü, Esad, Çelik, Ülker, Tarakçı, Nuriye, Armangil, Didem, Okulu, Emel, Narter, Fatma, Mutlu, Birgul, Mert, Mustafa Kurthan, Bülbül, Ali, Asker, Hüseyin Selim, Uygur, ÖzgÜn, Uslu, İlker Sait, Ertuğrul, Sabahattin, Aydemir, Cumhur, Çelik, Hasan Tolga, Küçüktaşçı, Kazım, Arslan, Selda, Ergin, Hacer, Zenciroğlu, Aysegül, Yurttutan, Sadık, Orman, Ayşen, Tuncer, Oğuz, Yaşa, Beril, Acunas, Betül, Takci, Şahin, Gökmen, Zeynel, Özkan, Hilal, Cömert, Serdar, Üstün, Nuran, Mutlu, Mehmet, Bayraktar, Bilge Tanyeri, Bilgin, Leyla, Tuzun, Funda, Aydemir, Özge, Akdağ, Arzu, Memisoğlu, Aslı, Can, Emrah, Terek, Demet, Beken, Serdar, Turan, Özden, Güzoğlu, Nilüfer, Örs, Rahmi, Kale, Yusuf, Hekimoğlu, Berna, Aylanc, Hakan, Eroğlu, Funda, Şahin, Suzan, Konak, Murat, Sarıcı, Dilek, Kılıç, İlknur, School of Medicine, Acibadem University Dspace, KKÜ, and Kırıkkale Üniversitesi

Subjects
Male, Turkey, Temel Bilimler (SCI), very low birth weight, ÇOK DİSİPLİNLİ BİLİMLER, Pathology and Laboratory Medicine, blood culture, Pediatrics, Infant, Newborn, Diseases, lung dysplasia, sepsis, Families, 0302 clinical medicine, newborn, Pregnancy, Birth Weight, Medicine, Prospective Studies, Children, [Anahtar Kelime Yok], Organic Compounds, adult, steroid, Pregnancy Outcome, clinical trial, Retinopathy of prematurity, cohort analysis, Bronchopulmonary dysplasia, Necrotizing enterocolitis, Morbidity, Mortality, Health, Prematurity, Infections, Countries, Distress, Sepsis, Physical Sciences, disease severity, prospective study, survival rate, medicine.medical_specialty, Science, Article, patent ductus arteriosus, 03 medical and health sciences, Signs and Symptoms, turkey (bird), Intensive Care Units, Neonatal, Intensive care, Humans, Retinopathy of Prematurity, human, Retinopathy, necrotizing enterocolitis, MULTIDISCIPLINARY SCIENCES, Chemical Compounds, Biology and Life Sciences, Neonates, Doğa Bilimleri Genel, medicine.disease, major clinical study, neonatal intensive care unit, Health Care, hospital discharge, Ophthalmology, Low birth weight, multicenter study, NATURAL SCIENCES, GENERAL, Population Groupings, Health Statistics, Neonatology, Developmental Biology, genetic structures, morbidity, hemodynamics, Neonatal Care, Turkey (republic), Medicine and Health Sciences, Infant, Very Low Birth Weight, 030212 general & internal medicine, gestational age, Prospective cohort study, Science and technology, Multidisciplinary, Temel Bilimler, Gestational age, newborn disease, Chemistry, female, Natural Sciences (SCI), brain hemorrhage, Retinal Disorders, Steroids, Female, Neonatal Sepsis, newborn morbidity, medicine.symptom, Natural Sciences, Infants, Research Article, Adult, Birth weight, Gestational Age, Turkish Neonatal Society, Diagnostic Medicine, 030225 pediatrics, retinopathy, controlled study, outcome assessment, perinatal period, Multidisipliner, business.industry, Organic Chemistry, prematurity, Infant, Newborn, infant, Age Groups, People and Places, Study, business, Early Neonatal Outcomes
Abstract

Beken, Serdar/0000-0002-8609-2684; BAS, AHMET YAGMUR/0000-0002-1329-2167; Bulbul, Ali/0000-0002-3510-3056; Karatekin, Guner/0000-0001-7112-0323, WOS: 000534242500056, PubMed: 31851725, Objective To investigate the early neonatal outcomes of very-low-birth-weight (VLBW) infants discharged home from neonatal intensive care units (NICUs) in Turkey. Material and methods A prospective cohort study was performed between April 1, 2016 and April 30, 2017. the study included VLBW infants admitted to level III NICUs. Perinatal and neonatal data of all infants born with a birth weight of.1500 g were collected for infants who survived. Results Data from 69 NICUs were obtained. the mean birth weight and gestational age were 1137 +/- 245 g and 29 +/- 2.4 weeks, respectively. During the study period, 78% of VLBW infants survived to discharge and 48% of survived infants had no major neonatal morbidity. VLBW infants who survived were evaluated in terms of major morbidities: bronchopulmonary dysplasia was detected in 23.7% of infants, necrotizing enterocolitis in 9.1%, blood culture proven late-onset sepsis (LOS) in 21.1%, blood culture negative LOS in 21.3%, severe intraventricular hemorrhage in 5.4% and severe retinopathy of prematurity in 11.1%. Hemodynamically significant patent ductus arteriosus was diagnosed in 24.8% of infants. Antenatal steroids were administered to 42.9% of mothers. Conclusion the present investigation is the first multicenter study to include epidemiological information on VLBW infants in Turkey. Morbidity rate in VLBW infants is a serious concern and higher than those in developed countries. Implementation of oxygen therapy with appropriate monitoring, better antenatal and neonatal care and control of sepsis may reduce the prevalence of neonatal morbidities. Therefore, monitoring standards of neonatal care and implementing quality improvement projects across the country are essential for improving neonatal outcomes in Turkish NICUs., Turkish Neonatal Society [2-2016]; Turkish Neonatal Society, This study was supported by the Turkish Neonatal Society, http://www.neonatology.org.tr, number 2-2016, received by AYB. Turkish Neonatal Society funded the study's online registry system. the funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Published
2019

12. Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units

Author

Bas, Ahmet Yagmur, Demirel, Nihal, Koc, Esin, Isik, Dilek Ulubas, Hirfanoglu, Ibrahim Murat, Tunc, Turan, Sari, Fatma Nur, Karatekin, Guner, Koklu, Esad, Altunhan, Huseyin, Turgut, Hatice, Narter, Fatma, Tarakci, Nuriye, Tekgunduz, Kadir Serafettin, Ozkiraz, Servet, Aydemir, Cumhur, Ozdemir, Ahmet, Cetinkaya, Bilin, Kazanci, Ebru, Tastekin, Ayhan, Calkavur, Sebnem, Ozyurt, Banu Mutlu, Demirelli, Yasar, Asker, Huseyin Selim, Mutlu, Birgul, Uygur, Ozgun, Ozkan, Hilal, Armangil, Didem, Ozlu, Ferda, Mert, Mustafa Kurthan, Ergin, Hacer, Ozcan, Beyza, Bas, Evrim Kiray, Okulu, Emel, Acunas, Betul, Celik, Ulker, Uslu, Sait Ilker, Mutlu, Mehmet, Demir, Nihat, Eroglu, Funda, Gokmen, Zeynel, Beken, Serdar, Bayraktar, Bilge Tanyeri, Hakan, Nilay, Kucuktasci, Kazim, Orman, Aysen, Comert, Serdar, Ertugrul, Sabahattin, Ustun, Nuran, Sahin, Ozlem, Terek, Demet, Kale, Yusuf, Konak, Murat, Yurttutan, Sadik, Aydemir, Ozge, Zenciroglu, Aysegul, Sarici, Dilek, Guzoglu, Nilufer, Hamilcikan, Sahin, Gursoy, Tugba, Tuzun, Funda, Ors, Rahmi, Arslan, Selda, Akdag, Arzu, Memisoglu, Asli, Yasa, Beril, Hekimoglu, Berna, Turan, Ozden, Aylanc, Hakan, Takci, Sahin, Celik, Tolga, Sahin, Suzan, Kilic, Ilknur, Kara, Caner, Tunay, Zuhal Ozen, Celik, Gokhan, Gozen, Ibrahim, Satirtav, Gunhal, Polat, Nihat, Oral, Ayse Yesim, Tokgoz, Mine, Keles, Sadullah, Bilgin, Burak, Ugurbas, Silay Canturk, Karaca, Cagatay, Keskek, Nedime Sahinoglu, Ekinci, Dilbade Yildiz, Balci, Ozlem, Altan, Emir Volkan, Bakbak, Sevda, Ceylan, Nihan Aksu, Kimyon, Sabit, Alyamac, Gunay, Ture, Gamze, Yildiz, Meral, Calis, Feyza, Sizmaz, Selcuk, Sukgen, Emine, Cetin, Ebru Nevin, Ozcimen, Muammer, Demir, Semra Tiryaki, Atila, Huban, Ozal, Altan, Tufaner, Gokhan, Yucel, Ozlem Eski, Kola, Mehmet, Seven, Erbil, Ozdek, Sengul, Durukan, Ali Hakan, Kal, Ali, Celebi, Ali Riza Cenk, Koytak, Ibrahim Arif, Alacamli, Goksu, Esme, Arif, Catak, Onur, Perente, Irfan, Sahin, Alparslan, Akcakaya, Aylin Ardagil, Kiray, Gulunay, Nalcaci, Serhat, Aksoy, Umit, Bakbak, Berker, Comez, Aysegul, Gursoy, Huseyin, Kabatas, Emrah Utku, Petricli, Ikbal Seza, Yumusak, Mehmet Erhan, Kirgiz, Ahmet, Uludag, Gunay, Yaman, Aylin, Dadaci, Zeynep, Karatas, Ali, Celiker, Hande, Cebeci, Zafer, Esenulku, Mahmut Cenap, Akkoyun, Imren, Ersan, Ismail, Demir, Selim, Kadayifcilar, Sibel, Unsal, Ayse Ipek Akyuz, Hocaoglu, Mumin, Grp, T. R.-R.O.P. Study, Ege Üniversitesi, Zonguldak Bülent Ecevit Üniversitesi, Çukurova Üniversitesi, Çocuk Sağlığı ve Hastalıkları, KOYTAK, İBRAHİM ARİF, Uludağ, Günay (ORCID & YÖK ID 175586), Gürsoy, Tuğba (ORCID 0000-0002-6084-4067 & YÖK ID 214691), Baş, Ahmet Yağmur, Demirel, Nihal, Koç, Esin, Işık, Dilek Ulubaş, Hirfanoğlu, İbrahim Murat, Tunç, Turan, Sarı, Fatma Nur, Karatekin, Güner, Köklü, Esad, Altunhan, Hüseyin, Turgut, Hatice, Narter, Fatma, Tarakçı, Nuriye, Tekgündüz, Kadir Şerafettin, Özkiraz, Servet, Aydemir, Cumhur, Özdemir, Ahmet, Çetinkaya, Bilin, Kazancı, Ebru, Taştekin, Ayhan, Calkavur, Şebnem, Özyurt, Banu Mutlu, Demirelli, Yaşar, Asker, Hüseyin Selim, Mutlu, Birgul, Uygur, Özgün, Özkan, Hilal, Armangil, Didem, Özlü, Ferda, Mert, Mustafa Kurthan, Ergin, Hacer, Özcan, Beyza, Baş, Evrim Kıray, Okulu, Emel, Acunas, Betül, Çelik, Ülker, Uslu, Sait İlker, Mutlu, Mehmet, Demir, Nihat, Eroğlu, Funda, Gökmen, Zeynel, Beken, Serdar, Bayraktar, Bilge Tanyeri, Hakan, Nilay, Küçüktaşçı, Kazım, Orman, Ayşen, Cömert, Serdar, Ertuğrul, Sabahattin, Üstün, Nuran, Şahin, Özlem, Terek, Demet, Kale, Yusuf, Konak, Murat, Yurttutan, Sadık, Aydemir, Özge, Zenciroğlu, Aysegül, Sarıcı, Dilek, Güzoğlu, Nilüfer, Hamilçıkan, Şahin, Tüzün, Funda, Örs, Rahmi, Arslan, Selda, Akdağ, Arzu, Memişoğlu, Aslı, Yasa, Beril, Hekimoğlu, Berna, Turan, Özden, Aylanc, Hakan, Takçı, Şahin, Çelik, Tolga, Şahin, Suzan, Kılıç, İlknur, Kara, Caner, Tunay, Zuhal Özen, Çelik, Gökhan, Gözen, İbrahim, Satırtav, Günhal, Polat, Nihat, Oral, Ayşe Yeşim, Tokgöz, Mine, Keleş, Sadullah, Bilgin, Burak, Uğurbaş, Silay Cantürk, Karaca, Çağatay, Keşkek, Nedime Şahinoğlu, Ekinci, Dilbade Yıldız, Balcı, Özlem, Altan, Emir Volkan, Bakbak, Sevda, Ceylan, Nihan Aksu, Kimyon, Sabit, Alyamaç, Günay, Türe, Gamze, Yıldız, Meral, Çalış, Feyza, Sızmaz, Selçuk, Sukgen, Emine, Çetin, Ebru Nevin, Özçimen, Muammer, Demir, Semra Tiryaki, Atila, Huban, Özal, Altan, Tufaner, Gökhan, Yücel, Özlem Eski, Kola, Mehmet, Seven, Erbil, Özdek, Şengül, Durukan, Ali Hakan, Kal, Ali, Çelebi, Ali Riza Cenk, Koytak, İbrahim Arif, Alaçamlı, Göksu, Esme, Arif, Çatak, Onur, Perente, İrfan, Şahin, Alparslan, Akçakaya, Aylin Ardagil, Kıray, Gülünay, Nalçacı, Serhat, Aksoy, Ümit, Bakbak, Berker, Çömez, Ayşegül, Gürsoy, Hüseyin, Kabataş, Emrah Utku, Petricli, İkbal Seza, Yumuşak, Mehmet Erhan, Kırgız, Ahmet, Yaman, Aylin, Dadacı, Zeynep, Karataş, Ali, Çeliker, Hande, Cebeci, Zafer, Esenülkü, Mahmut Cenap, Akkoyun, İmren, Ersan, İsmail, Demir, Selim, Kadayıfçılar, Sibel, Ünsal, Ayşe İpek Akyüz, Hocaoğlu, Mümin, School of Medicine, Department of Internal Medicine, MÜ, Kırıkkale Üniversitesi, Selçuk Üniversitesi, Bas, Ahmet Yagmur, Koc, Esin, Isik, Dilek Ulubas, Hirfanoglu, Ibrahim Murat, Tunc, Turan, Sari, Fatma Nur, Karatekin, Guner, Koklu, Esad, Altunhan, Huseyin, Tarakci, Nuriye, Tekgunduz, Kadir Serafettin, Ozkiraz, Servet, Ozdemir, Ahmet, Cetinkaya, Bilin, Kazanci, Ebru, Tastekin, Ayhan, Calkavur, Sebnem, Ozyurt, Banu Mutlu, Demirelli, Yasar, Asker, Huseyin Selim, Uygur, Ozgun, Ozkan, Hilal, Ozlu, Ferda, Ozcan, Beyza, Bas, Evrim Kiray, Acunas, Betul, Celik, Ulker, Uslu, Sait Ilker, Eroglu, Funda, Gokmen, Zeynel, Kucuktasci, Kazim, Orman, Aysen, Comert, Serdar, Ertugrul, Sabahattin, Ustun, Nuran, Sahin, Ozlem, Yurttutan, Sadik, Aydemir, Ozge, Zenciroglu, Aysegul, Sarici, Dilek, Guzoglu, Nilufer, Hamilcikan, Sahin, Gursoy, Tugba, Tuzun, Funda, Ors, Rahmi, Akdag, Arzu, Memisoglu, Asli, Hekimoglu, Berna, Turan, Ozden, Takci, Sahin, Celik, Tolga, Sahin, Suzan, Kilic, Ilknur, Tunay, Zuhal Ozen, Celik, Gokhan, Gozen, Ibrahim, Satirtav, Gunhal, Oral, Ayse Yesim, Tokgoz, Mine, Keles, Sadullah, Ugurbas, Silay Canturk, Karaca, Cagatay, Keskek, Nedime Sahinoglu, Ekinci, Dilbade Yildiz, Balci, Ozlem, Alyamac, Gunay, Ture, Gamze, Yildiz, Meral, Calis, Feyza, Sizmaz, Selcuk, Cetin, Ebru Nevin, Ozcimen, Muammer, Ozal, Altan, Tufaner, Gokhan, Yucel, Ozlem Eski, Ozdek, Sengul, Celebi, Ali Riza Cenk, Koytak, Ibrahim Arif, Alacamli, Goksu, Catak, Onur, Perente, Irfan, Sahin, Alparslan, Akcakaya, Aylin Ardagil, Kiray, Gulunay, Nalcaci, Serhat, Aksoy, Umit, Comez, Aysegul, Gursoy, Huseyin, Kabatas, Emrah Utku, Petricli, Ikbal Seza, Yumusak, Mehmet Erhan, Kirgiz, Ahmet, Uludag, Gunay, Dadaci, Zeynep, Karatas, Ali, Celiker, Hande, Esenulku, Mahmut Cenap, Akkoyun, Imren, Ersan, Ismail, Kadayifcilar, Sibel, Unsal, Ayse Ipek Akyuz, Hocaoglu, Mumin, OMÜ, Tıp Fakültesi, and Acibadem University Dspace

Subjects
Male, BLOOD-TRANSFUSION, Pediatrics, Turkey, INFANTS, Logistic regression, 0302 clinical medicine, Risk Factors, FOR-GESTATIONAL-AGE, Prevalence, Birth Weight, Infant, Very Low Birth Weight, Prospective Studies, Prospective cohort study, [Anahtar Kelime Yok], Neovascularisation, Incidence, Incidence (epidemiology), Gestational age, Retinopathy of prematurity, Clinical Science, Sensory Systems, Female, Infant, Premature, Child health (paediatrics), Retina, Treatment medical, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Birth weight, Gestational Age, Sepsis, 03 medical and health sciences, Cellular and Molecular Neuroscience, Neonatal Screening, Intensive Care Units, Neonatal, 030225 pediatrics, Intensive care, medicine, Humans, Retinopathy of Prematurity, business.industry, Child Health (paediatrics), Infant, Newborn, [No Keywords], Infant, medicine.disease, eye diseases, Ophthalmology, For-Gestational-Age, TR-ROP Study, 030221 ophthalmology & optometry, Treatment Medical, Blood-Transfusion, WEIGHT, Weight, Infants, Severity of Retinopathy, business, Medicine
Abstract

Background To evaluate the prevalence, risk factors and treatment of retinopathy of prematurity (ROP) in Turkey and to establish screening criteria for this condition., Methods A prospective cohort study (TR-ROP) was performed between 1 April 2016 and 30 April 2017 in 69 neonatal intensive care units (NICUs). Infants with a birth weight (BW)=1500 g or gestational age (GA) 1500 g or GA> 32 weeks with an unstable clinical course were included in the study. Predictors for the development of ROP were determined by logistic regression analyses., Results The TR-ROP study included 6115 infants: 4964 (81%) with a GA 32 weeks. Overall, 27% had any stage of ROP and 6.7% had severe ROP. A lower BW, smaller GA, total days on oxygen, late-onset sepsis, frequency of red blood cell transfusions and relative weight gain were identified as independent risk factors for severe ROP in infants with a BW=1500 g. Of all infants, 414 needed treatment and 395 (95.4%) of the treated infants had a BW, Conclusions Screening of infants with a GA

Published
2018

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