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2. A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint

Author

Kevin P. Guay, Roberta Ibba, J.L. Kiappes, Snežana Vasiljević, Francesco Bonì, Maria De Benedictis, Ilaria Zeni, James D. Le Cornu, Mario Hensen, Anu V. Chandran, Anastassia L. Kantsadi, Alessandro T. Caputo, Juan I. Blanco Capurro, Yusupha Bayo, Johan C. Hill, Kieran Hudson, Andrea Lia, Juliane Brun, Stephen G. Withers, Marcelo Martí, Emiliano Biasini, Angelo Santino, Matteo De Rosa, Mario Milani, Carlos P. Modenutti, Daniel N. Hebert, Nicole Zitzmann, and Pietro Roversi

Subjects
Chemistry, Cell biology, Functional aspects of cell biology, Science
Abstract

Summary: Misfolded glycoprotein recognition and endoplasmic reticulum (ER) retention are mediated by the ER glycoprotein folding quality control (ERQC) checkpoint enzyme, UDP-glucose glycoprotein glucosyltransferase (UGGT). UGGT modulation is a promising strategy for broad-spectrum antivirals, rescue-of-secretion therapy in rare disease caused by responsive mutations in glycoprotein genes, and many cancers, but to date no selective UGGT inhibitors are known. The small molecule 5-[(morpholin-4-yl)methyl]quinolin-8-ol (5M-8OH-Q) binds a CtUGGTGT24 “WY” conserved surface motif conserved across UGGTs but not present in other GT24 family glycosyltransferases. 5M-8OH-Q has a 47 μM binding affinity for CtUGGTGT24 in vitro as measured by ligand-enhanced fluorescence. In cellula, 5M-8OH-Q inhibits both human UGGT isoforms at concentrations higher than 750 μM. 5M-8OH-Q binding to CtUGGTGT24 appears to be mutually exclusive to M5-9 glycan binding in an in vitro competition experiment. A medicinal program based on 5M-8OH-Q will yield the next generation of UGGT inhibitors.

Published
2023
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4. Unveiling crucial amino acids in the carbohydrate recognition domain of a viral protein through a structural bioinformatic approach.

Author

Gamarra, Marcelo D, Dieterle, Maria Eugenia, Ortigosa, Juan, Lannot, Jorge O, Capurro, Juan I Blanco, Paola, Matias Di, Radusky, Leandro, Duette, Gabriel, Piuri, Mariana, and Modenutti, Carlos P

Subjects
PROTEIN-carbohydrate interactions, PROTEIN domains, VIRAL proteins, MOLECULAR dynamics, MOLECULAR docking
Abstract

Carbohydrate binding modules (CBMs) are protein domains that typically reside near catalytic domains, increasing substrate-protein proximity by constraining the conformational space of carbohydrates. Due to the flexibility and variability of glycans, the molecular details of how these protein regions recognize their target molecules are not always fully understood. Computational methods, including molecular docking and molecular dynamics simulations, have been employed to investigate lectin-carbohydrate interactions. In this study, we introduce a novel approach that integrates multiple computational techniques to identify the critical amino acids involved in the interaction between a CBM located at the tip of bacteriophage J-1's tail and its carbohydrate counterparts. Our results highlight three amino acids that play a significant role in binding, a finding we confirmed through in vitro experiments. By presenting this approach, we offer an intriguing alternative for pinpointing amino acids that contribute to protein-sugar interactions, leading to a more thorough comprehension of the molecular determinants of protein-carbohydrate interactions. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Metabolic profile in endothelial cells of chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension

Author

V. F. E. D. Smolders, C. Rodríguez, I. Blanco, R. Szulcek, Wim Timens, L. Piccari, Y. Roger, X. Hu, Constanza Morén, C. Bonjoch, L. Sebastián, M. Castellà, J. Osorio, V. I. Peinado, Harm Jan Bogaard, P. H. A. Quax, M. Cascante, J. A. Barberà, and O. Tura-Ceide

Subjects
Medicine, Science
Abstract

Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH) are two forms of pulmonary hypertension (PH) characterized by obstructive vasculopathy. Endothelial dysfunction along with metabolic changes towards increased glycolysis are important in PAH pathophysiology. Less is known about such abnormalities in endothelial cells (ECs) from CTEPH patients. This study provides a systematic metabolic comparison of ECs derived from CTEPH and PAH patients. Metabolic gene expression was studied using qPCR in cultured CTEPH-EC and PAH-EC. Western blot analyses were done for HK2, LDHA, PDHA1, PDK and G6PD. Basal viability of CTEPH-EC and PAH-EC with the incubation with metabolic inhibitors was measured using colorimetric viability assays. Human pulmonary artery endothelial cells (HPAEC) were used as healthy controls. Whereas PAH-EC showed significant higher mRNA levels of GLUT1, HK2, LDHA, PDHA1 and GLUD1 metabolic enzymes compared to HPAEC, CTEPH-EC did not. Oxidative phosphorylation associated proteins had an increased expression in PAH-EC compared to CTEPH-EC and HPAEC. PAH-EC, CTEPH-EC and HPAEC presented similar HOXD macrovascular gene expression. Metabolic inhibitors showed a dose-dependent reduction in viability in all three groups, predominantly in PAH-EC. A different metabolic profile is present in CTEPH-EC compared to PAH-EC and suggests differences in molecular mechanisms important in the disease pathology and treatment.

Published
2022
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6. Anàlisi de les activitats laborals y processos operatius en una empresa

Author

Universitat Politècnica de Catalunya. Departament de Tecnologia de l'Arquitectura, SBS, Simon i Blanco, Capellà Llovera, Joaquim, Petit Saludes, Núria, Ayala Ovelar, Julian Tadeo, Universitat Politècnica de Catalunya. Departament de Tecnologia de l'Arquitectura, SBS, Simon i Blanco, Capellà Llovera, Joaquim, Petit Saludes, Núria, and Ayala Ovelar, Julian Tadeo

Abstract

Els processos de recepció i execució han estat punts centrals en la gestió d'aquest projecte immobiliari. La meticulosa verificació dels materials durant la recepció ha estat crucial per assegurar que compleixin els requisits tècnics, establint les bases per a una execució exitosa. En el procés d'execució, la supervisió directa dels replantejaments, materials i disposició dels elements constructius ha mantingut els estàndards de qualitat desitjats i ha previngut possibles desviacions. Pel que fa als elements acabats, reconec la seva importància crucial, malgrat no haver-me centrat totalment en aquesta fase. La continuïtat dels materials, com la poliurea i la làmina asfàltica, és essencial per prevenir filtracions i assegurar la solidesa estructural a llarg termini. Encara que no l'he vist completament, aquesta fase és crucial per garantir la conformitat amb els estàndards de qualitat fins a l'últim detall. Amb una obra d'aquesta envergadura, he tingut l'oportunitat de presenciar diverses fases, des de les fonamentacions fins als acabats, vivint de prop el desenvolupament de les cases. L'experiència de construir a la Cerdanya, en comparació amb l'àrea metropolitana de Barcelona, ha revelat diferències notables. Pel que fa als processos de control de qualitat, he notat la necessitat de molta documentació, amb cada material passant per diverses verificacions abans de la seva col·locació final. Tots els processos són essencials, i em satisfà veure que el nostre criteri és ben rebut. Entre els aspectes menys satisfactoris destaco el control fotogràfic del sanejament, un procés monòton que requereix revisar cada foto individualment a les carpetes del servidor des del principi de l'obra. No obstant això, el que m'ha agradat més és la revisió del ferro, especialment el del forjat del soterrani, que es presenta com una tasca fascinant.

Published
2024

7. Examining the sustainability and development challenge in agricultural-forest frontiers of the Amazon Basin through the eyes of locals

Author

I. Blanco-Gutiérrez, R. Manners, C. Varela-Ortega, A. M. Tarquis, L. G. Martorano, and M. Toledo

Subjects
Environmental technology. Sanitary engineering, TD1-1066, Geography. Anthropology. Recreation, Environmental sciences, GE1-350, Geology, QE1-996.5
Abstract

The Amazon basin is the world's largest rainforest and the most biologically diverse place on Earth. Despite the critical importance of this region, Amazon forests continue inexorably to be degraded and deforested for various reasons, mainly a consequence of agricultural expansion. The development of novel policy strategies that provide balanced solutions, associating economic growth with environmental protection, is still challenging, largely because the perspective of those most affected – local stakeholders – is often ignored. Participatory fuzzy cognitive mapping (FCM) was implemented to examine stakeholder perceptions towards the sustainable development of two agricultural-forest frontier areas in the Bolivian and Brazilian Amazon. A series of development scenarios were explored and applied to stakeholder-derived FCM, with climate change also analysed. Stakeholders in both regions perceived landscapes of socio-economic impoverishment and environmental degradation driven by governmental and institutional deficiencies. Under such abject conditions, governance and well-integrated social and technological strategies offered socio-economic development, environmental conservation, and resilience to climatic changes. The results suggest there are benefits of a new type of thinking for development strategies in the Amazon basin and that continued application of traditional development policies reduces the resilience of the Amazon to climate change, whilst limiting socio-economic development and environmental conservation.

Published
2020
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8. Consenso de procesamiento de endoscopios flexibles

Author

Claudia I. Blanco-Vela, Mario Peláez-Luna, Clara L. Martínez-García, Jony Cerna-Cardona, Claudia Martínez-Camacho, Xochiquétzal Sánchez-Chávez, Ángel Reyes-Dorantes, Omar E. Trujillo-Benavides, Héctor Espino-Cortés, Samantha González-Labrada, Félix I. Téllez-Ávila, María E. López-Acosta, Diego Angulo-Molina, Martha Moreno, Esteban de Icaza-del Río, Einar Guzmán-Islas, Pablo Baltazar-Montufar, Rodrigo Soto-Solís, Orlando Bada-Yllán, and Rachel Campos-Jiménez

Subjects
Endoscopia. Endoscopio flexible. Limpieza. Desinfección. Procesamiento., Other systems of medicine, RZ201-999
Abstract

La garantía de calidad en la higiene y el control de infecciones es una herramienta importante para prevenir las infecciones asociadas a la atención de salud. En endoscopia es indispensable contar con el equipo de protección adecuado para el manejo de material potencialmente infeccioso durante el procedimiento y el reprocesamiento de los equipos. El presente manuscrito es el consenso alcanzado por miembros de la Asociación Mexicana de Endoscopia Gastrointestinal (AMEG) sobre el procesamiento de endoscopios flexibles y propone estrategias de limpieza y desinfección del material utilizado en los procedimientos endoscópicos de acuerdo con los lineamientos internacionales y la disponibilidad de recursos en nuestro país, basándose en la evidencia científica disponible en la actualidad.

Published
2022
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9. Consenso de indicadores de calidad en la atención en colangiopancreatografía retrógrada endoscópica

Author

Claudia I. Blanco-Vela, Mario Peláez-Luna, Clara L. Martínez-García, Jordán Zamora-Godínez, Ángela Saúl-Pérez, Jony Cerna-Cardona, Enrique Murcio-Pérez, Claudia Martínez-Camacho, Aurelio López-Colombo, Fernando Pérez-Aguilar, Ana L. Desales-Iturbe, Fernando Rojas-Mendoza, Luis Mejía-Cuan, Héctor Espino-Cortés, Rodrigo Soto-Solís, María E. López-Acosta, Angélica Hernández-Guerrero, Ma del Carmen Manzano-Robleda, Juan O. Alonso-Larrága, Ariosto Hernández-Lara, Sergio Solana-Sentíes, Orlando Bada-Yllán, Joel O. Jáquez-Quintana, and Yolanda Zamorano-Orozco

Subjects
Indicadores de calidad, CPRE, Colangiopancreatografía, Cuidado de la salud., Other systems of medicine, RZ201-999
Abstract

La colangiopancreatografía retrógrada endoscópica (CPRE) es uno de los procedimientos endoscópicos más complejos y ampliamente utilizados. El equipo encargado de realizar una CPRE debe ofrecer la máxima eficiencia y seguridad durante el procedimiento. Para lograr calidad en la realización de CPRE deben establecerse indicadores de calidad. El presente manuscrito es el consenso desarrollado por la AMEG sobre indicadores de calidad en atención de la salud al efectuar una CPRE. Dichos indicadores se establecen dentro de un marco conceptual que toma en cuenta la evidencia científica disponible en la actualidad y la disponibilidad de recursos en nuestro país.

Published
2021
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11. Amperometric detection of triclosan with screen-printed carbon nanotube electrodes modified with Guinea Grass (Panicum maximum) peroxidase

Author

Angie E Orduz, Angie E Orduz, Sergio I Blanco, John J Castillo

Subjects
amperometric biosensor, carbon nanotubes, guinea grass peroxidase, screen printed electrodes, triclosan., Science (General), Q1-390
Abstract

Triclosan is a compound with antimicrobial activity broadly used in consumer products. Because of its well-documented toxicity, the amount of triclosan present in different products needs to be tightly controlled. This paper outlines a new amperometric sensor for triclosan detection consisting of a screen-printed carbon nanotube electrode (SPCNE) modified with Guinea grass peroxidase (GGP). The GGP-modified SPCNE was able to detect an enhanced electrochemical response of triclosan, unlike the bare SPCNE. The cyclic voltammograms of the GGP-modified SPCNE in a solution of potassium ferrocyanide showed an increase in the current values and linearity between scan rates and oxidation peak currents, suggesting a surface-controlled process. The GGP-modified SPCNE showed an excellent electrocatalytic activity to triclosan oxidation, at a redox potential of 370 mV, in the presence of hydrogen peroxide, exhibiting a linear response between 20 mM to 80 mM and a detection limit of 3 µM. This new amperometry system, based on carbon nanotubes integrated with GGP, becomes a potential tool for environmental analysis and food quality control.

Published
2019
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12. Effects of a participatory approach, with systematic impact matrix analysis in herd health planning in organic dairy cattle herds

Author

K. Sjöström, S. Sternberg-Lewerin, I. Blanco-Penedo, J.E. Duval, M. Krieger, U. Emanuelson, and N. Fall

Subjects
animal health, decision making, farm-specific tools, on-farm assessment, advisory, Animal culture, SF1-1100
Abstract

The animal health and welfare status in European organic dairy production does not in all aspects meet the organic principles and consumers’ expectations and needs to be improved. To achieve this, tailored herd health planning, targeted to the specific situation of individual farms could be of use. The aim of this study was to apply herd health planning in a structured participatory approach, with impact matrix analysis, not previously used in this context, in European organic dairy farms and to assess changes in animal health and welfare. Herd health planning farm visits were conducted on 122 organic dairy farms in France, Germany and Sweden. The farmer, the herd veterinarian and/or an advisor took part in the farm discussions. The researcher served as facilitator. Baseline data on the animal health status of the individual farm, collected from national milk recording schemes, were presented as an input for the discussion. Thereafter a systematic impact matrix analysis was performed. This was to capture the complexity of individual farms with the aim to identify the farm-specific factors that could have a strong impact on animal health. The participants (i.e. farmer, veterinarian and advisor) jointly identified areas in need of improvement, taking the health status and the interconnected farm system components into account, and appropriate actions were jointly identified. The researcher took minutes during the discussions, and these were shared with the participants. No intervention was made by the researcher, and further actions were left with the participants. The number of actions per farm ranged from 0 to 22. The change in mortality, metabolic diseases, reproductive performance and udder health was assessed at two time points, and potential determinators of the change were evaluated with linear regression models. A significant association was seen between change in udder health, as measured by the somatic cell count, and country. At the first follow-up, a significant association was also found between change in the proportion of prolonged calving interval and the farmers’ desire to improve reproductive health as well as with an increase in herd size, but this was not seen at the second follow-up. The degree of implementation of the actions was good (median 67%, lower quartile 40%, upper quartile 83%). To conclude, the degree of implementation was quite high, improvement of animal health could not be linked to the herd health planning approach. However, the approach was highly appreciated by the participants and deserves further study.

Published
2019
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16. Non-destructive evaluation of carcass and ham traits and meat quality assessment applied to early and late immunocastrated Iberian pigs

Author

M. Font-i-Furnols, J. García-Gudiño, M. Izquierdo, A. Brun, M. Gispert, I. Blanco-Penedo, and F.I. Hernández-García

Subjects
Computed tomography, Consumer, Fatness, Pork, Ultrasound, Animal culture, SF1-1100
Abstract

Castration is a common practice in Iberian pigs due to their advanced age and high weight at slaughter. Immunocastration (IC) is an alternative to surgical castration that influences carcass and cut fatness. These traits need to be evaluated in vivo and postmortem. The aims of the present work were (a) to determine the relationship between ham composition measured with computed tomography (CT) and in vivo ultrasound (US) and carcass fat thickness measurements, (b) to apply these technologies to early (EIP) and late (LIP) immunocastrated Iberian pigs in order to evaluate carcass fatness and ham tissue composition and (c) to assess meat quality on these animals and to find the relationships between meat quality traits (namely, intramuscular fat (IMF)) and fat depot thicknesses. For this purpose, 20 purebred Iberian pigs were immunocastrated with three doses of Improvac ®, at either 4.5, 5.5 and 9 or 11, 12 and 14 months of age (EIP or LIP; respectively; n = 10 each) and slaughtered at 17 months of age. Fat depots were evaluated in vivo by US, in carcass with a ruler and in hams by CT. Carcass and cut yields, loin meat quality and loin acceptability by consumers were determined. Also, IMF was determined in the loin and three muscles of the ham. Carcass weight was 14.9 kg heavier in EIP vs LIP, and loin backfat thickness (US- and ruler-measured) was also greater in EIP. Similarly, CT-evaluated ham bone and fat contents were greater and smaller for EIP vs LIP, respectively. Loin and ham IMF were also greater in EIP, but the other meat quality parameters were similar. The acceptability of meat by consumers was high and it did not differ between IC protocols. Correlations between several fat depots measured with the different technologies were high. In conclusion, all these technologies allowed fat depot measurements, which were highly correlated despite being obtained at different anatomical locations.

Published
2021
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17. Short communication: Identifying key parameters for modelling the impacts of livestock health conditions on greenhouse gas emissions

Author

R.P. Kipling, A. Bannink, D.J. Bartley, I. Blanco-Penedo, P. Faverdin, A.-I. Graux, N.J. Hutchings, I. Kyriazakis, M. Macleod, S. Østergaard, T.P. Robinson, A. Vitali, B. Vosough Ahmadi, and Ş. Özkan

Subjects
Agricultural modelling, Climate change, Dairy production, Greenhouse gas emissions, Livestock health, Animal culture, SF1-1100
Abstract

Improved animal health can reduce greenhouse gas (GHG) emissions intensity in livestock systems while increasing productivity. Integrated modelling of disease impacts on farm-scale emissions is important in identifying effective health strategies to reduce emissions. However, it requires that modellers understand the pathways linking animal health to emissions and how these might be incorporated into models. A key barrier to meeting this need has been the lack of a framework to facilitate effective exchange of knowledge and data between animal health experts and emissions modellers. Here, these two communities engaged in workshops, online exchanges and a survey to i) identify a comprehensive list of disease-related model parameters and ii) test its application to evaluating models. Fifty-six parameters were identified and proved effective in assessing the potential of farm-scale models to characterise livestock disease impacts on GHG emissions. Easy wins for the emissions models surveyed include characterising disease impacts related to feeding.

Published
2021
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19. Three‐Dimensional Magnetic Models of La Gomera (Canary Islands): Insights Into the Early Evolution of an Ocean Island Volcano

Author

I. Blanco‐Montenegro, F. G. Montesinos, I. Nicolosi, J. Arnoso, and M. Chiappini

Subjects
Magnetic anomalies, inversion of potential fields, volcanic islands, aeromagnetic data, basal complex, canary islands, Geophysics. Cosmic physics, QC801-809, Geology, QE1-996.5
Abstract

Abstract An aeromagnetic data set from the island of La Gomera was studied through two inverse modeling approaches that produced complementary views of the inner structure of this volcanic island: (1) a variable magnetization model that identified the main lateral magnetization contrasts and (2) a constant magnetization model that imaged the main magnetic source by assuming that it was a uniformly magnetized body. The modeling reveals intense magnetizations beneath the northern part of La Gomera, which occupy an important portion of the northern submarine edifice, correspond well with outcrops of the submarine volcano (Basal Complex), and confirm that most of the magnetic signal revealed by aeromagnetic mapping in the Canary Islands is due to the intense magnetizations of the intrusive complexes (plutonic bodies and dike complexes) emplaced during the initial stages of growth of the volcanic edifices. The consistency of our models with the results of a previous gravimetric study suggests that these intrusive complexes are denser and more magnetic than the surrounding rocks. The location of the main magnetic source reinforces the interpretation, first suggested by geological evidence, that the submarine and early subaerial growth of La Gomera started to the north of the present island. The elongated shape of these intrusive complexes with a nearly E‐W strike agrees with the orientation of analogous structures on Tenerife and Gran Canaria, suggesting that the initial formation of the central islands of the Canary Archipelago was controlled by a set of regional fractures in a strike‐slip tectonic framework.

Published
2020
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22. The IASLC Lung Cancer Staging Project: External Validation of the Revision of the TNM Stage Groupings in the Eighth Edition of the TNM Classification of Lung Cancer

Author

Goldstraw, Peter, Rami-Porta, Ramón, Asamura, Hisao, Ball, David, Beer, David G., Beyruti, Ricardo, Bolejack, Vanessa, Chansky, Kari, Crowley, John, Detterbeck, Frank, Erich Eberhardt, Wilfried Ernst, Edwards, John, Galateau-Sallé, Françoise, Giroux, Dorothy, Gleeson, Fergus, Groome, Patti, Huang, James, Kennedy, Catherine, Kim, Jhingook, Kim, Young Tae, Kingsbury, Laura, Kondo, Haruhiko, Krasnik, Mark, Kubota, Kaoru, Lerut, Antoon, Lyons, Gustavo, Marino, Mirella, Marom, Edith M., van Meerbeeck, Jan, Mitchell, Alan, Nakano, Takashi, Nicholson, Andrew G., Nowak, Anna, Peake, Michael, Rice, Thomas, Rosenzweig, Kenneth, Ruffini, Enrico, Rusch, Valerie, Saijo, Nagahiro, Van Schil, Paul, Sculier, Jean-Paul, Shemanski, Lynn, Stratton, Kelly, Suzuki, Kenji, Tachimori, Yuji, Thomas, Charles F., Jr., Travis, William, Tsao, Ming S., Turrisi, Andrew, Vansteenkiste, Johan, Watanabe, Hirokazu, Wu, Yi-Long, Baas, Paul, Erasmus, Jeremy, Hasegawa, Seiki, Inai, Kouki, Kernstine, Kemp, Kindler, Hedy, Krug, Lee, Nackaerts, Kristiaan, Pass, Harvey, Rice, David, Falkson, Conrad, Filosso, Pier Luigi, Giaccone, Giuseppe, Kondo, Kazuya, Lucchi, Marco, Okumura, Meinoshin, Blackstone, Eugene, Cavaco, F. Abad, Barrera, E. Ansótegui, Arca, J. Abal, Lamelas, I. Parente, Obrer, A. Arnau, Jorge, R. Guijarro, Ball, D., Bascom, G.K., Orozco, A. I. Blanco, Castro, M. A. González, Blum, M.G., Chimondeguy, D., Cvijanovic, V., Defranchi, S., de Olaiz Navarro, B., Campuzano, I. Escobar, Vidueira, I. Macía, Araujo, E. Fernández, García, F. Andreo, Fong, K.M., Corral, G. Francisco, González, S. Cerezo, Gilart, J. Freixinet, Arangüena, L. García, Barajas, S. García, Girard, P., Goksel, T., Budiño, M. T. González, Casaurrán, G. González, Blanco, J. A. Gullón, Hernández, J. Hernández, Rodríguez, H. Hernández, Collantes, J. Herrero, Heras, M. Iglesias, Elena, J. M. Izquierdo, Jakobsen, E., Kostas, S., Atance, P. León, Ares, A. Núñez, Liao, M., Losanovscky, M., Lyons, G., Magaroles, R., De Esteban Júlvez, L., Gorospe, M. Mariñán, McCaughan, B., Kennedy, C., Íñiguez, R. Melchor, Sorribes, L. Miravet, Gozalo, S. Naranjo, Álvarez de Arriba, C., Delgado, M. Núñez, Alarcón, J. Padilla, Cuesta, J. C. Peñalver, Park, J.S., Pass, H., Fernández, M. J. Pavón, Rosenberg, M., Ruffini, E., Rusch, V., Sánchez de Cos Escuín, J., Vinuesa, A. Saura, Mitjans, M. Serra, Strand, T.E., Subotic, D., Swisher, S., Terra, R., Thomas, C., Tournoy, K., Van Schil, P., Velasquez, M., Wu, Y.L., Yokoi, K., Detterbeck, Frank C., Rusch, Valerie W., Vallières, Eric, and Crowley, John J.

Published
2017
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23. Follow-up of Specialist in Cardiology Graduates at University of Buenos Aires. Cosme Argerich Hospital Experience

Author

Lucía R. Kazelián, Leandro A. Bono, Mariela Tolusso, Horacio G. Cestari, Rodrigo I. Blanco, and Juan A. Gagliardi

Abstract

Background: Follow-up of graduates in a career is an indicator of educational quality, and their professional and academic work allows evaluating the results of long-term instituted programs Objective: The aim of this study was to explore the perception of graduates from the postgraduate specialist course (PSC) in cardiology at University of Buenos Aires (UBA) Hospital Argerich venue on the quality of training received, how they insert in the professional world, and their engagement in subspecialties. Methods: A descriptive, cross-sectional study was carried out from January 1 to 31, 2020. A self-administered opinion survey was designed using surveymonkey.com and submitted to 28 graduates of the PSC in cardiology UBA-Hospital Argerich, corresponding to 7 consecutive promotions (2010-2016 years of admission). Results: The survey was answered by 25 graduates (89.2%). Mean age was 34 years and 14 (56%) were men. The questions explored the global assessment, the evaluation of the scientific and academic activity at the hospital venue as well as that of the Argentine Society of Cardiology Biennial Course of Cardiology. Most of the answers were favorable. All the graduates continue practicing the profession and 76% have received advanced training in a subspecialty. Conclusions: Graduates from the PSC in cardiology at Hospital Argerich perceive that their training has been very good or excellent and has been essential for their professional development. All the data collected are a source of information to provide feedback and optimize teaching in the training institution.

Published
2022
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24. Seguimiento de graduados de la Carrera de Médico Especialista en cardiología de la Universidad de Buenos Aires. Experiencia del Hospital Cosme Argerich

Author

Lucía R. Kazelián, Leandro A. Bono, Mariela E. Tolusso, Horacio G. Cestari, Rodrigo I. Blanco, and Juan A. Gagliardi

Abstract

El seguimiento de los graduados en una carrera es un indicador de la calidad educativa de la misma. Su labor profesional y académica permite evaluar los resultados de los programas instituidos a largo plazo. Objetivo: Explorar la percepción de los egresados de la Carrera de Médico Especialista (CME) en cardiología de la Universidad de Buenos Aires (UBA) sede Hospital Argerich sobre la calidad de la formación recibida durante la carrera; conocer su inserción laboral en el mundo profesional, y la realización de subespecialidades. Material y métodos: Estudio descriptivo, de corte transversal, realizado del 1° al 31 de enero de 2020. Se diseñó una encuesta de opinión autoadministrada a través de surveymonkey.com. El universo encuestado fueron 28 egresados de 7 promociones consecutivas (año de admisión 2010-2016) de la Carrera de Médico Especialista (CME) en cardiología UBA-sede Argerich. Resultados: Del total de los egresados contestaron la encuesta 25 (89,2%). La edad promedio fue 34 años, sexo masculino 14 (56%). Se realizaron preguntas para la evaluación global, valoración de la actividad científica y académica en la Sede del Hospital, al igual que la valoración del Curso Bianual de Cardiología en la Sociedad Argentina de Cardiología. Las respuestas en su mayoría fueron favorables Los egresados continúan ejerciendo la profesión en un 100%, el 76% se perfeccionó en una subespecialidad. Conclusiones: Los egresados de la CME en cardiología sede Hospital Argerich perciben que su formación ha sido muy buena o excelente y ha contribuido a su desarrollo profesional de manera esencial. Toda la información recabada genera una fuente de información para retroalimentar y optimizar la enseñanza en la institución formadora.

Published
2022
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26. The Structural Biology of Galectin-Ligand Recognition: Current Advances in Modeling Tools, Protein Engineering, and Inhibitor Design

Author

Carlos P. Modenutti, Juan I. Blanco Capurro, Santiago Di Lella, and Marcelo A. Martí

Subjects
galectin, structure, carbohydrate, water sites, docking, drug-design, Chemistry, QD1-999
Abstract

Galectins (formerly known as “S-type lectins”) are a subfamily of soluble proteins that typically bind β-galactoside carbohydrates with high specificity. They are present in many forms of life, from nematodes and fungi to animals, where they perform a wide range of functions. Particularly in humans, different types of galectins have been described differing not only in their tissue expression but also in their cellular location, oligomerization, fold architecture and carbohydrate-binding affinity. This distinct yet sometimes overlapping distributions and physicochemical attributes make them responsible for a wide variety of both intra- and extracellular functions, including tremendous importance in immunity and disease. In this review, we aim to provide a general description of galectins most important structural features, with a special focus on the molecular determinants of their carbohydrate-recognition ability. For that purpose, we structurally compare the human galectins, in light of recent mutagenesis studies and novel X-ray structures. We also offer a detailed description on how to use the solvent structure surrounding the protein as a tool to get better predictions of galectin-carbohydrate complexes, with a potential application to the rational design of glycomimetic inhibitory compounds. Finally, using Gal-1 and Gal-3 as paramount examples, we review a series of recent advances in the development of engineered galectins and galectin inhibitors, aiming to dissect the structure-activity relationship through the description of their interaction at the molecular level.

Published
2019
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27. The IASLC Lung Cancer Staging Project: Methodology and Validation Used in the Development of Proposals for Revision of the Stage Classification of NSCLC in the Forthcoming (Eighth) Edition of the TNM Classification of Lung Cancer

Author

Goldstraw, Peter, Rami-Porta, Ramón, Asamura, Hisao, Ball, David, Beer, David G., Beyruti, Ricardo, Bolejack, Vanessa, Chansky, Kari, Crowley, John, Detterbeck, Frank, Eberhardt, Wilfried Ernst Erich, Edwards, John, Galateau-Sallé, Françoise, Giroux, Dorothy, Gleeson, Fergus, Groome, Patti, Huang, James, Kennedy, Catherine, Kim, Jhingook, Kim, Young Tae, Kingsbury, Laura, Kondo, Haruhiko, Krasnik, Mark, Kubota, Kaoru, Lerut, Antoon, Lyons, Gustavo, Marino, Mirella, Marom, Edith M., van Meerbeeck, Jan, Mitchell, Alan, Nakano, Takashi, Nicholson, Andrew G., Nowak, Anna, Peake, Michael, Rice, Thomas, Rosenzweig, Kenneth, Ruffini, Enrico, Rusch, Valerie, Saijo, Nagahiro, Van Schil, Paul, Sculier, Jean-Paul, Shemanski, Lynn, Stratton, Kelly, Suzuki, Kenji, Tachimori, Yuji, Thomas, Charles F., Jr., Travis, William, Tsao, Ming S., Turrisi, Andrew, Vansteenkiste, Johan, Watanabe, Hirokazu, Wu, Yi-Long, Baas, Paul, Erasmus, Jeremy, Hasegawa, Seiki, Inai, Kouki, Kernstine, Kemp, Kindler, Hedy, Krug, Lee, Nackaerts, Kristiaan, Pass, Harvey, Rice, David, Falkson, Conrad, Filosso, Pier Luigi, Giaccone, Giuseppe, Kondo, Kazuya, Lucchi, Marco, Okumura, Meinoshin, Blackstone, Eugene, Cavaco, F. Abad, Barrera, E. Ansótegui, Arca, J. Abal, Lamelas, I. Parente, Obrer, A. Arnau, Jorge, R. Guijarro, Ball, D., Bascom, G.K., Orozco, A. I. Blanco, Castro, M. A. González, Blum, M.G., Chimondeguy, D., Cvijanovic, V., Defranchi, S., de Olaiz Navarro, B., Campuzano, I. Escobar, Vidueira, I. Macía, Araujo, E. Fernández, García, F. Andreo, Fong, K.M., Corral, G. Francisco, González, S. Cerezo, Gilart, J. Freixinet, Arangüena, L. García, Barajas, S. García, Girard, P., Goksel, T., Budiño, M. T. González, Casaurrán, G. González, Blanco, J. A. Gullón, Hernández, J. Hernández, Rodríguez, H. Hernández, Collantes, J. Herrero, Heras, M. Iglesias, Elena, J. M. Izquierdo, Jakobsen, E., Kostas, S., Atance, P. León, Ares, A. Núñez, Liao, M., Losanovscky, M., Lyons, G., Magaroles, R., De Esteban Júlvez, L., Gorospe, M. Mariñán, McCaughan, B., Kennedy, C., Íñiguez, R. Melchor, Sorribes, L. Miravet, Gozalo, S. Naranjo, de Arriba, C. Álvarez, Delgado, M. Núñez, Alarcón, J. Padilla, Cuesta, J. C. Peñalver, Park, J.S., Fernández, M. J. Pavón, Rosenberg, M., Ruffini, E., Rusch, V., de Cos Escuín, J. Sánchez, Vinuesa, A. Saura, Mitjans, M. Serra, Strand, T.E., Subotic, D., Swisher, S., Terra, R., Thomas, C., Tournoy, K., Van Schil, P., Velasquez, M., Wu, Y.L., Yokoi, K., Rami-Porta, Ramon, Giroux, Dorothy J., Travis, William D., van Schil, Paul, Zielinski, Marcin, Eberhardt, Wilfried, van Meeerbeeck, Jan, Nicholson, Andrew, Kubota, Kouru, Bankier, Alex, Beasley, Mary Beth, Flieder, Douglas B., Goo, Jin Mo, MacMahon, Heber, Naidich, David, Powell, Charles A., Prokop, Mathias, Yatabe, Yasushi, Arenberg, Douglas A., Donington, Jessica S., Franklin, Wilbur A., Girard, Nicolas, Mazzone, Peter J., Rusch, Valerie W., Tanoue, Lynn T., and Detterbeck, Frank C.

Published
2016
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34. Cetylpyridinium Chloride Mouthwash to Reduce Shedding of Infectious SARS-CoV-2: A Double-Blind Randomized Clinical Trial

Author

A, Alemany, D, Perez-Zsolt, D, Raïch-Regué, J, Muñoz-Basagoiti, D, Ouchi, C, Laporte-Villar, B, Baro, N, Henríquez, N, Prat, M Ochoa, Gianinetto, M Viaplana, Gutiérrez, M Garcia, Sánchez-Paniagua, N Larrosa, Henríquez, J Moreno, Vicente, J, Ara, M A, Rodriguez-Arias, J, Puig, I, Blanco, C Casañ, Lopez, Á, Hernández, A E, Bordoy, C Esteban, Redondo, V González, Soler, M, Giménez, V, Blanc, R, León, J, Gispert, B, Clotet, N, Izquierdo-Useros, and O, Mitjà

Subjects
viral shedding, SARS-CoV-2, Mouthwashes, COVID-19, mouthwashes, Cetylpyridinium, Middle Aged, Nucleocapsid Proteins, Virus Shedding, Chlorides, Double-Blind Method, randomized controlled trials, cetylpyridinium chloride, Humans, RNA, Viral, General Dentistry
Abstract

The airborne transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via respiratory fluids and droplets suggests that mouthwashes containing substances with virucidal activity can help reduce viral spread. We conducted a multicenter, double-blind, placebo-controlled, randomized trial to assess the virucidal activity of cetylpyridinium chloride (CPC) mouthwashes. Outpatients who tested positive for SARS-CoV-2 infection with or without symptoms were randomized to perform washes and gargles for 1 min with 15 mL of either colored distilled water or 0.07% CPC (Vitis CPC Protect) mouthwash. The study outcomes were the SARS-CoV-2 log10 viral RNA load and the nucleocapsid protein levels, both in saliva at 1 and 3 h after the intervention. In total, 118 patients were enrolled and randomized (mean [SD], age 46 [14] y). Thirteen of 118 participants (11%) did not complete follow-up or had insufficient sample volume for testing and were excluded from the analysis. The assessment of the viral load showed no significant differences between groups at any of the investigated points. However, the levels of SARS-CoV-2 nucleocapsid protein of lysed viruses were significantly higher in the CPC group compared with the control group at 1 h (adjusted difference 269.3 pg/mL; 95% confidence interval [CI], 97.1–441.5) and at 3 h postintervention (561.1 pg/mL; 95% CI, 380.0–742.2). In nonhospitalized patients with asymptomatic or mild symptomatic SARS-CoV-2 infection, a 0.07% CPC mouthwash, compared to placebo, was associated with a significant increase of nucleocapsid protein levels in saliva, indicating enhanced disruption of viral particles.

Published
2022
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35. ESICM LIVES 2016: part one

Author

L. Bos, L. Schouten, L. van Vught, M. Wiewel, D. Ong, O. Cremer, A. Artigas, I. Martin-Loeches, A. Hoogendijk, T. van der Poll, J. Horn, N. Juffermans, M. Schultz, N. de Prost, T. Pham, G. Carteaux, A. Mekontso Dessap, C. Brun-Buisson, E. Fan, G. Bellani, J. Laffey, A. Mercat, L. Brochard, B. Maitre, LUNG SAFE investigators and the ESICM study group, P. A. Howells, D. R. Thickett, C. Knox, D. P. Park, F. Gao, O. Tucker, T. Whitehouse, D. F. McAuley, G. D. Perkins, LUNG SAFE Investigators and the ESICM Trials Group, L. Pisani, J. P. Roozeman, F. D. Simonis, A. Giangregorio, L. R. Schouten, S. M. Van der Hoeven, A. Serpa Neto, E. Festic, A. M. Dondorp, S. Grasso, L. D. Bos, M. J. Schultz, M. Koster-Brouwer, D. Verboom, B. Scicluna, K. van de Groep, J. Frencken, M. Bonten, J. I. Ko, K. S. Kim, G. J. Suh, W. Y. Kwon, K. Kim, J. H. Shin, O. T. Ranzani, E. Prina, R. Menendez, A. Ceccato, R. Mendez, C. Cilloniz, A. Gabarrus, M. Ferrer, A. Torres, A. Urbano, L. A. Zhang, D. Swigon, F. Pike, R. S. Parker, G. Clermont, C. Scheer, S. O. Kuhn, A. Modler, M. Vollmer, C. Fuchs, K. Hahnenkamp, S. Rehberg, M. Gründling, A. Taggu, N. Darang, N. Öveges, I. László, K. Tánczos, M. Németh, G. Lebák, B. Tudor, D. Érces, J. Kaszaki, W. Huber, D. Trásy, Z. Molnár, G. Ferrara, V. S. Kanoore Edul, H. S. Canales, E. Martins, C. Canullán, G. Murias, M. O. Pozo, J. F. Caminos Eguillor, M. G. Buscetti, C. Ince, A. Dubin, H. D. Aya, A. Rhodes, N. Fletcher, R. M. Grounds, M. Cecconi, M. Jacquet-Lagrèze, M. Riche, R. Schweizer, P. Portran, W. Fornier, M. Lilot, J. Neidecker, J. L. Fellahi, A. Escoresca-Ortega, A. Gutiérrez-Pizarraya, L. Charris-Castro, Y. Corcia-Palomo, E. Fernandez-Delgado, J. Garnacho-Montero, C. Roger, L. Muller, L. Elotmani, J. Lipman, J. Y. Lefrant, J. A. Roberts, R. Muñoz-Bermúdez, M. Samper, C. Climent, F. Vasco, V. Sara, S. Luque, N. Campillo, S. Grau Cerrato, J. R. Masclans, F. Alvarez-Lerma, S. Carvalho Brugger, G. Jimenez Jimenez, M. Miralbés Torner, J. Trujillano Cabello, B. Balsera Garrido, X. Nuvials Casals, F. Barcenilla Gaite, M. Vallverdú Vidal, M. Palomar Martínez, V. Gusarov, D. Shilkin, M. Dementienko, E. Nesterova, N. Lashenkova, A. Kuzovlev, M. Zamyatin, A. Demoule, S. Carreira, S. Lavault, O. Palancca, E. Morawiec, J. Mayaux, I. Arnulf, T. Similowski, B. S. Rasmussen, R. G. Maltesen, M. Hanifa, S. Pedersen, S. R. Kristensen, R. Wimmer, M. Panigada, G. Li Bassi, T. Kolobow, A. Zanella, M. Cressoni, L. Berra, V. Parrini, H. Kandil, G. Salati, S. Livigni, A. Amatu, A. Andreotti, F. Tagliaferri, G. Moise, G. Mercurio, A. Costa, A. Vezzani, S. Lindau, J. Babel, M. Cavana, D. Consonni, A. Pesenti, L. Gattinoni, for the GRAVITY-VAP TRIAL NETWORK, P. Mansouri, F. Zand, L. Zahed, F. Dehghanrad, M. Bahrani, M. Ghorbani, B. Cambiaghi, O. Moerer, T. Mauri, N. Kunze-Szikszay, C. Ritter, M. Quintel, L. M. Vilander, M. A. Kaunisto, S. T. Vaara, V. Pettilä, FINNAKI Study Group, J. L. G. Haitsma Mulier, S. Rozemeijer, A. M. E. Spoelstra-de Man, P. E. Elbers, P. R. Tuinman, M. C. de Waard, H. M. Oudemans-van Straaten, A. M. A. Liberatore, R. B. Souza, A. M. C. R. P. F. Martins, J. C. F. Vieira, I. H. J. Koh, M. Galindo Martínez, R. Jiménez Sánchez, L. Martínez Gascón, M. D. Rodríguez Mulero, A. Ortín Freire, A. Ojados Muñoz, S. Rebollo Acebes, Á. Fernández Martínez, S. Moreno Aliaga, L. Herrera Para, J. Murcia Payá, F. Rodríguez Mulero, P. Guerci, Y. Ince, P. Heeman, B. Ergin, Z. Uz, M. Massey, R. Papatella, E. Bulent, F. Toraman, E. R. Longbottom, H. D. Torrance, H. C. Owen, C. J. Hinds, R. M. Pearse, M. J. O’Dywer, Z. Trogrlic, M. van der Jagt, H. Lingsma, H. H. Ponssen, J. F. Schoonderbeek, F. Schreiner, S. J. Verbrugge, S. Duran, T. van Achterberg, J. Bakker, D. A. M. P. J. Gommers, E. Ista, A. Krajčová, P. Waldauf, F. Duška, A. Shah, N. Roy, S. McKechnie, C. Doree, S. Fisher, S. J. Stanworth, J. F. Jensen, D. Overgaard, M. H. Bestle, D. F. Christensen, I. Egerod, The RAPIT Group, A. Pivkina, I. Zhivotneva, N. Pasko, A. Alklit, R. L. Hansen, H. Knudsen, L. B. Grode, The RAPIT group, M. Hravnak, L. Chen, A. Dubrawski, M. R. Pinsky, S. M. Parry, L. D. Knight, B. C. Connolly, C. E. Baldwin, Z. A. Puthucheary, L. Denehy, N. Hart, P. E. Morris, J. Mortimore, C. L. Granger, H. I. Jensen, R. Piers, B. Van den Bulcke, J. Malmgren, V. Metaxa, A. K. Reyners, M. Darmon, K. Rusinova, D. Talmor, A. P. Meert, L. Cancelliere, L. Zubek, P. Maia, A. Michalsen, J. Decruyenaere, E. Kompanje, S. Vanheule, E. Azoulay, S. Vansteelandt, D. Benoit, C. Ryan, D. Dawson, J. Ball, K. Noone, B. Aisling, S. Prudden, A. Ntantana, D. Matamis, S. Savvidou, M. Giannakou, M. Gouva, G. Nakos, V. Koulouras, J. Aron, G. Lumley, D. Milliken, K. Dhadwal, B. A. McGrath, S. J. Lynch, B. Bovento, G. Sharpe, E. Grainger, S. Pieri-Davies, S. Wallace, B. McGrath, M. Jung, J. Cho, H. Park, G. Suh, O. Kousha, J. Paddle, L. Gamrin Gripenberg, M. Sundström Rehal, J. Wernerman, O. Rooyackers, H. J. de Grooth, W. P. Choo, A. M. Spoelstra-de Man, E. L. Swart, L. Talan, G. Güven, N. D. Altıntas, M. Padar, G. Uusvel, L. Starkopf, J. Starkopf, A. Reintam Blaser, M. S. Kalaiselvan, A. S. Arunkumar, M. K. Renuka, R. L. Shivkumar, M. Volbeda, D. ten Kate, M. Hoekstra, J. M. van der Maaten, M. W. Nijsten, A. Komaromi, Å. Norberg, M. Smedberg, M. Mori, L. Pettersson, M. Theodorakopoulou, T. Christodoulopoulou, A. Diamantakis, F. Frantzeskaki, M. Kontogiorgi, E. Chrysanthopoulou, M. Lygnos, C. Diakaki, A. Armaganidis, K. Gundogan, E. Dogan, R. Coskun, S. Muhtaroglu, M. Sungur, T. Ziegler, M. Guven, A. Kleyman, W. Khaliq, D. Andreas, M. Singer, R. Meierhans, R. Schuepbach, I. De Brito-Ashurst, G. Sabetian, R. Nikandish, F. Hagar, M. Masjedi, B. Maghsudi, A. Vazin, E. Asadpour, K. C. Kao, L. C. Chiu, C. Y. Hung, C. H. Chang, S. H. Li, H. C. Hu, S. El Maraghi, M. Ali, D. Rageb, M. Helmy, J. Marin-Corral, C. Vilà, A. Vàzquez, I. Martín-Loeches, E. Díaz, J. C. Yébenes, A. Rodriguez, F. Álvarez-Lerma, H1N1 SEMICYUC/GETGAG Working Group, N. Varga, A. Cortina-Gutiérrez, L. Dono, M. Martínez-Martínez, C. Maldonado, E. Papiol, M. Pérez-Carrasco, R. Ferrer, K. Nweze, B. Morton, I. Welters, M. Houard, B. Voisin, G. Ledoux, S. Six, E. Jaillette, S. Nseir, S. Romdhani, R. Bouneb, D. Loghmari, N. Ben Aicha, J. Ayachi, K. Meddeb, I. Chouchène, A. Khedher, M. Boussarsar, K. S. Chan, W. L. Yu, J. Nolla, L. Vidaur, J. Bonastre, B. Suberbiola, J. E. Guerrero, H1N1 SEMICYUC/GETGAG working group, N. Ramon Coll, G. Jiménez Jiménez, J. Codina Calero, M. García, M. C. de la Torre, E. Vendrell, E. Palomera, E. Güell, M. Serra-Prat, J. F. Bermejo-Martín, J. Almirall, E. Tomas, A. Escoval, F. Froe, M. H. Vitoria Pereira, N. Velez, E. Viegas, E. Filipe, C. Groves, M. Reay, A. Ballin, F. Facchin, G. Sartori, F. Zarantonello, E. Campello, C. M. Radu, S. Rossi, C. Ori, P. Simioni, N. Umei, I. Shingo, A. C. Santos, C. Candeias, I. Moniz, R. Marçal, Z. Costa e Silva, J. M. Ribeiro, J. F. Georger, J. P. Ponthus, M. Tchir, V. Amilien, M. Ayoub, E. Barsam, G. Martucci, G. Panarello, F. Tuzzolino, G. Capitanio, V. Ferrazza, T. Carollo, L. Giovanni, A. Arcadipane, M. López Sánchez, M. A. González-Gay, F. J. Llorca Díaz, M. I. Rubio López, E. Zogheib, L. Villeret, J. Nader, M. Bernasinski, P. Besserve, T. Caus, H. Dupont, P. Morimont, S. Habran, R. Hubert, T. Desaive, F. Blaffart, N. Janssen, J. Guiot, A. Pironet, P. Dauby, B. Lambermont, T. Pettenuzzo, G. Citton, C. Kirakli, O. Ediboglu, S. Ataman, M. Yarici, F. Tuksavul, S. Keating, A. Gibson, M. Gilles, M. Dunn, G. Price, N. Young, P. Remeta, P. Bishop, M. D. Fernández Zamora, J. Muñoz-Bono, E. Curiel-Balsera, E. Aguilar-Alonso, R. Hinojosa, A. Gordillo-Brenes, J. A. Arboleda-Sánchez, ARIAM-CARDIAC SURGERY PROJECT AUTHORS, I. Skorniakov, D. Vikulova, C. Whiteley, O. Shaikh, A. Jones, M. Ostermann, L. Forni, M. Scott, J. Sahatjian, W. Linde-Zwirble, D. Hansell, P. Laoveeravat, N. Srisawat, M. Kongwibulwut, S. Peerapornrattana, N. Suwachittanont, T. O. Wirotwan, P. Chatkaew, P. Saeyub, K. Latthaprecha, K. Tiranathanagul, S. Eiam-ong, J. A. Kellum, R. E. Berthelsen, A. Perner, A. E. K. Jensen, J. U. Jensen, D. J. Gebhard, J. Price, C. E. Kennedy, A. Akcan-Arikan, Y. R. Kang, M. N. Nakamae, K. Hamed, M. M. Khaled, R. Aly Soliman, M. Sherif Mokhtar, G. Seller-Pérez, D. Arias-Verdú, E. Llopar-Valdor, I. De-Diós-Chacón, G. Quesada-García, M. E. Herrera-Gutierrez, R. Hafes, G. Carroll, P. Doherty, C. Wright, I. G. Guerra Vera, M. Ralston, M. L. Gemmell, A. MacKay, E. Black, R. I. Docking, R. Appleton, M. R. Ralston, L. Gemmell, A. Mackay, J. G. Röttgering, P. W. G. Elbers, N. Mejeni, J. Nsiala, A. Kilembe, P. Akilimali, G. Thomas, A. E. Andersson, A. M. Fagerdahl, V. Knudsen, P-INFECT, A. Ben Cheikh, Y. Hamdaoui, A. Guiga, N. Fraj, N. Sma, I. Chouchene, N. Bouafia, A. Amirian, B. Ziaian, C. Fleischmann, D. O. Thomas-Rueddel, A. Schettler, D. Schwarzkopf, A. Stacke, K. Reinhart, A. Martins, P. Sousa, G. Snell, R. Matsa, T. T. S. Paary, A. M. Cavalheiro, L. L. Rocha, C. S. Vallone, A. Tonilo, M. D. S. Lobato, D. T. Malheiro, G. Sussumo, N. M. Lucino, V. D. Rosenthal, A. Sanaei Dashti, A. Yousefipour, J. R. Goodall, M. Williamson, E. Tant, N. Thomas, C. Balci, C. Gonen, E. Haftacı, H. Gurarda, E. Karaca, B. Paldusová, I. Zýková, D. Šímová, S. Houston, L. D’Antona, J. Lloyd, V. Garnelo-Rey, M. Sosic, V. Sotosek-Tokmazic, J. Kuharic, I. Antoncic, S. Dunatov, A. Sustic, C. T. Chong, M. Sim, T. Lyovarin, F. M. Acosta Díaz, S. Narbona Galdó, M. Muñoz Garach, O. Moreno Romero, A. M. Pérez Bailón, A. Carranza Pinel, M. Colmenero, A. Gritsan, A. Gazenkampf, E. Korchagin, N. Dovbish, R. M. Lee, M. P. P. Lim, B. C. L. Lim, J. J. See, R. Assis, F. Filipe, N. Lopes, L. Pessoa, T. Pereira, N. Catorze, M. S. Aydogan, C. Aldasoro, P. Marchio, A. Jorda, M. D. Mauricio, S. Guerra-Ojeda, M. Gimeno-Raga, M. Colque-Cano, A. Bertomeu-Artecero, M. Aldasoro, S. L. Valles, D. Tonon, T. Triglia, J. C. Martin, M. C. Alessi, N. Bruder, P. Garrigue, L. Velly, S. Spina, V. Scaravilli, C. Marzorati, E. Colombo, D. Savo, A. Vargiolu, G. Cavenaghi, G. Citerio, A. H. V. Andrade, P. Bulgarelli, J. A. P. Araujo, V. Gonzalez, V. A. Souza, C. Massant, C. A. C. Abreu Filho, R. A. Morbeck, L. E. Burgo, R. van Groenendael, L. T. van Eijk, G. P. Leijte, B. Koeneman, M. Kox, P. Pickkers, A. García-de la Torre, M. de la Torre-Prados, A. Fernández-Porcel, C. Rueda-Molina, P. Nuevo-Ortega, T. Tsvetanova-Spasova, E. Cámara-Sola, A. García-Alcántara, L. Salido-Díaz, X. Liao, T. Feng, J. Zhang, X. Cao, Q. Wu, Z. Xie, H. Li, Y. Kang, M. S. Winkler, A. Nierhaus, E. Mudersbach, A. Bauer, L. Robbe, C. Zahrte, E. Schwedhelm, S. Kluge, C. Zöllner, E. Mitsi, S. H. Pennington, J. Reine, A. D. Wright, R. Parker, I. D. Welters, J. D. Blakey, G. Rajam, E. W. Ades, D. M. Ferreira, D. Wang, A. Kadioglu, S. B. Gordon, R. Koch, J. Rahamat-Langedoen, J. Schloesser, M. de Jonge, J. Bringue, R. Guillamat-Prats, E. Torrents, M. L. Martinez, M. Camprubí-Rimblas, L. Blanch, S. Y. Park, Y. B. Park, D. K. Song, S. Shrestha, S. H. Park, Y. Koh, M. J. Park, C. W. Hong, O. Lesur, D. Coquerel, X. Sainsily, J. Cote, T. Söllradl, A. Murza, L. Dumont, R. Dumaine, M. Grandbois, P. Sarret, E. Marsault, D. Salvail, M. Auger-Messier, F. Chagnon, Apelin Group, M. P. Lauretta, E. Greco, A. Dyson, S. Preau, M. Ambler, A. Sigurta, S. Saeed, L. Topcu Sarıca, N. Zibandeh, D. Genc, F. Gul, T. Akkoc, E. Kombak, L. Cinel, I. Cinel, S. J. Pollen, N. Arulkumaran, G. Warnes, D. J. Pennington, K. Brohi, M. J. O’Dwyer, H. Y. Kim, S. Na, J. Kim, Y. F. Chang, A. Chao, P. Y. Shih, C. T. Lee, Y. C. Yeh, L. W. Chen, M. Adriaanse, W. Rietdijk, S. Funcke, S. Sauerlaender, B. Saugel, H. Pinnschmidt, D. A. Reuter, R. Nitzschke, S. Perbet, C. Biboulet, A. Lenoire, D. Bourdeaux, B. Pereira, B. Plaud, J. E. Bazin, V. Sautou, A. Mebazaa, J. M. Constantin, M. Legrand, Y. Boyko, P. Jennum, M. Nikolic, H. Oerding, R. Holst, P. Toft, H. K. Nedergaard, T. Haberlandt, S. Park, S. Kim, Y. J. Cho, Y. J. Lim, A. Chan, S. Tang, S. L. Nunes, S. Forsberg, H. Blomqvist, L. Berggren, M. Sörberg, T. Sarapohja, C. J. Wickerts, J. G. M. Hofhuis, L. Rose, B. Blackwood, E. Akerman, J. Mcgaughey, M. Fossum, H. Foss, E. Georgiou, H. J. Graff, M. Kalafati, R. Sperlinga, A. Schafer, A. G. Wojnicka, P. E. Spronk, F. Khalili, R. Afshari, H. Haddad Khodaei, S. Javadpour, P. Petramfar, S. Nasimi, H. Tabei, A. Gunther, J. O. Hansen, P. Sackey, H. Storm, J. Bernhardsson, Ø. Sundin, A. Bjärtå, A. Bienert, P. Smuszkiewicz, P. Wiczling, K. Przybylowski, A. Borsuk, I. Trojanowska, J. Matysiak, Z. Kokot, M. Paterska, E. Grzeskowiak, A. Messina, E. Bonicolini, D. Colombo, G. Moro, S. Romagnoli, A. R. De Gaudio, F. Della Corte, S. M. Romano, J. A. Silversides, E. Major, E. E. Mann, A. J. Ferguson, D. F. Mcauley, J. C. Marshall, J. A. Diaz-Rodriguez, R. Silva-Medina, E. Gomez-Sandoval, N. Gomez-Gonzalez, R. Soriano-Orozco, P. L. Gonzalez-Carrillo, M. Hernández-Flores, K. Pilarczyk, J. Lubarksi, D. Wendt, F. Dusse, J. Günter, B. Huschens, E. Demircioglu, H. Jakob, A. Palmaccio, A. M. Dell’Anna, D. L. Grieco, F. Torrini, C. Iaquaniello, F. Bongiovanni, M. Antonelli, L. Toscani, D. Antonakaki, D. Bastoni, M. Jozwiak, F. Depret, J. L. Teboul, J. Alphonsine, C. Lai, C. Richard, X. Monnet, G. Demeter, I. Kertmegi, A. Hasanin, A. Lotfy, A. El-adawy, H. Nassar, S. Mahmoud, A. Abougabal, A. Mukhtar, F. Quinty, S. Habchi, A. Luzi, E. Antok, G. Hernandez, B. Lara, L. Enberg, M. Ortega, P. Leon, C. Kripper, P. Aguilera, E. Kattan, M. Lehmann, S. Sakka, B. Bein, R. M. Schmid, J. Preti, J. Creteur, A. Herpain, J. Marc, F. Trojette, S. Bar, L. Kontar, D. Titeca, J. Richecoeur, B. Gelee, N. Verrier, R. Mercier, E. Lorne, J. Maizel, M. Slama, M. E. Abdelfattah, A. Eladawy, M. A. Ali Elsayed, A. Pedraza Montenegro, E. Monares Zepeda, J. Franco Granillo, J. S. Aguirre Sánchez, G. Camarena Alejo, A. Rugerio Cabrera, A. A. Tanaka Montoya, C. Lee, F. Hatib, M. Cannesson, P. Theerawit, T. Morasert, Y. Sutherasan, G. Zani, S. Mescolini, M. Diamanti, R. Righetti, A. Scaramuzza, M. Papetti, M. Terenzoni, C. Gecele, M. Fusari, K. A. Hakim, A. Chaari, M. Ismail, A. H. Elsaka, T. M. Mahmoud, K. Bousselmi, V. Kauts, W. F. Casey, S. D. Hutchings, D. Naumann, J. Wendon, S. Watts, E. Kirkman, Z. Jian, S. Buddi, J. Settels, P. Bertini, F. Guarracino, C. Trepte, P. Richter, S. A. Haas, V. Eichhorn, J. C. Kubitz, M. S. Soliman, W. I. Hamimy, A. Z. Fouad, A. M. Mukhtar, M. Charlton, L. Tonks, L. Mclelland, T. J. Coats, J. P. Thompson, M. R. Sims, D. Williams, D. Z. Roushdy, R. A. Soliman, R. A. Nahas, M. Y. Arafa, W. T. Hung, C. C. Chiang, W. C. Huang, K. C. Lin, S. C. Lin, C. C. Cheng, P. L. Kang, S. R. Wann, G. Y. Mar, C. P. Liu, M. Lopez Carranza, H. Sancho Fernandez, J. A. Sanchez Roman, F. Lucena, A. Campanario Garcia, A. Loza Vazquez, A. Lesmes Serrano, ARIAM-SEMICYUC Registry Investigators, L. Sayagues Moreira, R. Vidal-Perez, U. Anido Herranz, J. M. Garcia Acuna, C. Pena Gil, J. L. Garcia Allut, P. Rascado Sedes, C. Martin Lopez, E. Saborido Paz, C. Galban Rodriguez, J. R. Gonzalez-Juanatey, A. Vallejo-Baez, M. V. de la Torre-Prados, ARIAM Group, R. Marharaj, K. Gervasio, M. Bottiroli, M. Mondino, D. De Caria, A. Calini, E. Montrasio, F. Milazzo, M. P. Gagliardone, A. Vallejo-Báez, ARIAM group, U. Anido, M. Cheikh-Bouhlel, M. P. R. D. L. Dela Cruz, J. M. Bernardo, F. Galfo, A. Marino, C. C. Chao, P. Hou, C. C. Hung, C. H. Chiang, Y. J. Liou, S. M. Hung, Y. S. Lin, F. Y. Kuo, K. R. Chiou, C. J. Chen, L. S. Yan, C. Y. Liu, H. H. Wang, H. L. Chen, C. K. Ho, S. Grewal, S. Gopal, C. Corbett, A. Wilson, J. Capps, W. Ayoub, A. Lomas, S. Ghani, J. Moore, D. Atkinson, M. Sharman, W. Swinnen, J. Pauwels, K. Mignolet, E. Pannier, A. Koch, T. Sarens, W. Temmerman, A. M. Elmenshawy, A. M. Fayed, M. Elboriuny, E. Hamdy, E. Zakaria, A. C. Falk, A. Petosic, K. Olafsen, H. Wøien, H. Flaatten, K. Sunde, J. J. Cáceres Agra, J. L. Santana Cabrera, J. D. Martín Santana, L. Melián Alzola, H. Rodríguez Pérez, T. Castro Pires, H. Calderón, A. Pereira, S. Castro, C. Granja, I. Norkiene, I. Urbanaviciute, G. Kezyte, D. Ringaitiene, T. Jovaisa, G. Vogel, U. B. Johansson, A. Sandgren, C. Svensen, E. Joelsson-Alm, M. A. Leite, L. D. Murbach, E. F. Osaku, C. R. L. M. Costa, M. Pelenz, N. M. Neitzke, M. M. Moraes, J. L. Jaskowiak, M. M. M. Silva, R. S. Zaponi, L. R. L. Abentroth, S. M. Ogasawara, A. C. Jorge, P. A. D. Duarte, J. Barreto, S. T. Duarte, S. Taba, D. Miglioranza, D. P. Gund, C. F. Lordani, H. Vollmer, M. Gager, C. Waldmann, A. T. Mazzeo, R. Tesio, C. Filippini, M. E. Vallero, C. Giolitti, S. Caccia, M. Medugno, T. Tenaglia, R. Rosato, I. Mastromauro, L. Brazzi, P. P. Terragni, R. Urbino, V. Fanelli, V. M. Ranieri, L. Mascia, J. Ballantyne, L. Paton, P. Perez-Teran, O. Roca, J. C. Ruiz-Rodriguez, A. Zapatero, J. Serra, S. Bianzina, P. Cornara, G. Rodi, G. Tavazzi, M. Pozzi, G. A. Iotti, F. Mojoli, A. Braschi, A. Vishnu, D. Buche, R. Pande, D. L. J. Moolenaar, F. Bakhshi-Raiez, D. A. Dongelmans, N. F. de Keizer, D. W. de Lange, I. Fuentes Fernández, D. Martínez Baño, J. L. Buendía Moreno, R. Jara Rubio, J. Scott, D. Phelan, D. Morely, J. O’Flynn, P. Stapleton, M. Lynch, B. Marsh, E. Carton, C. O’Loughlin, K. C. Cheng, M. I. Sung, M. O. Elghonemi, M. H. Saleh, T. S. Meyhoff, M. Krag, P. B. Hjortrup, M. H. Møller, T. Öhman, T. Sigmundsson, E. Redondo, M. Hallbäck, F. Suarez-Sipmann, H. Björne, C. Hällsjö Sander, KARISMA, D. Chiumello, C. Chiurazzi, M. Brioni, I. Algieri, M. Guanziroli, G. Vergani, T. Tonetti, I. Tomic, A. Colombo, F. Crimella, E. Carlesso, V. Gasparovic, R. El-Sherif, M. Abd Al-Basser, A. Raafat, A. El-Sherif, L. R. A. Schouten, O. L. Cremer, D. S. Y. Ong, G. Amoruso, G. Cinnella, L. D. J. Bos, P. Schmidle, M. Findeisen, P. Hoppmann, J. Jaitner, F. Brettner, T. Lahmer, EXODUS-investigators, G. Rajagopalan, V. Bansal, R. Frank, R. Hinds, J. Levitt, United States Critical Illness and Injury Trials Group/LIPS-B investigators, S. Siddiqui, SICM NICER Group, J. P. Gilbert, K. Sim, C. H. Wang, I. J. Li, W. R. Tang, P. Persona, A. De Cassai, M. Franco, A. Goffi, B. Llorente Ruiz, J. Lujan Varas, R. Molina Montero, C. Pintado Delgado, O. Navarrete, M. Vazquez Mezquita, E. Alonso Peces, M. A. M. Nakamura, L. A. Hajjar, F. R. B. G. Galas, T. A. Ortiz, M. B. P. Amato, L. Bitker, N. Costes, D. Le Bars, F. Lavenne, D. Mojgan, J. C. Richard, D. Massari, M. Gotti, P. Cadringher, A. Zerman, M. Türkoğlu, G. Arık, F. Yıldırım, Z. Güllü, I. Kara, N. Boyacı, B. Basarık Aydoğan, Ü. Gaygısız, K. Gönderen, G. Aygencel, M. Aydoğdu, Z. Ülger, G. Gürsel, J. Riera, C. Maldonado Toral, C. Mazo, M. Martínez, J. Baldirà, L. Lagunes, A. Roman, M. Deu, J. Rello, D. J. Levine, R. M. Mohus, Å. Askim, J. Paulsen, A. Mehl, A. T. Dewan, J. K. Damås, E. Solligård, B. O. Åsvold, Mid-Norway Sepsis Research Center, A. DeWan, O. Aktepe, A. Kara, H. Yeter, A. Topeli, M. Norrenberg, M. Devroey, H. Khader, J. C. Preiser, Z. Tang, C. Qiu, L. Tong, C. Cai, O. Apostolopoulou, J. Y. Moon, M. R. Park, I. S. Kwon, G. R. Chon, J. Y. Ahn, S. J. Kwon, Y. J. Chang, J. Y. Lee, S. Y. Yoon, J. W. Lee, The Korean Chungcheong Critical Care Research Group, M. Kostalas, J. Mckinlay, G. Kooner, G. Dudas, A. Horton, C. Kerr, N. Karanjia, B. Creagh-Brown, N. D. Altintas, S. Izdes, O. Keremoglu, A. Alkan, S. Neselioglu, O. Erel, N. Tardif, T. Gustafsson, K. N. MacEachern, M. Traille, I. Bromberg, S. E. Lapinsky, M. J. Moore, J. L. García-Garmendia, F. Villarrasa-Clemente, F. Maroto-Monserrat, O. Rufo-Tejeiro, V. Jorge-Amigo, M. Sánchez-Santamaría, C. Colón-Pallarés, A. Barrero-Almodóvar, S. Gallego-Lara, C. T. Anthon, R. B. Müller, N. Haase, K. Møller, J. Wetterslev, M. Nakanishi, A. Kuriyama, T. Fukuoka, M. A. Abd el Halim, M. H. Elsaid hafez, A. M. Moktar, H. M. Elazizy, K. Abdel Hakim, M. Elbahr, T. Mahmoud, E. Khalil, W. Casey, S. H. Zaky, A. Rizk, R. Ahmed, G. A. Ospina-Tascón, A. F. Garcia Marin, G. J. Echeverry, W. F. Bermudez, H. J. Madriñan-Navia, J. D. Valencia, E. Quiñonez, A. Marulanda, C. A. Arango-Dávila, A. Bruhn, D. De Backer, D. Orbegozo Cortes, F. Su, J. L. Vincent, L. Tullo, L. Mirabella, P. Di Molfetta, M. Dambrosio, C. Villavicencio Lujan, J. Leache irigoyen, M. Cartanya ferré, R. Carbonell García, M. Ahmed, M. El Ayashi, E. Ayman, M. Salem, S. Fathy, A. Zaghlol, M. F. Aguilar Arzapalo, Å. Valsø, T. Rustøen, I. Schou-Bredal, L. Skogstad, K. Tøien, C. Padilla, Y. Palmeiro, W. Egbaria, R. Kigli, B. Maertens, K. Blot, S. Blot, E. Santana-Santos, E. R. dos Santos, R. E. D. L. Ferretti-Rebustini, R. D. C. C. D. O. dos Santos, R. G. S. Verardino, L. A. Bortolotto, A. M. Doyle, I. Naldrett, J. Tillman, S. Price, P. Pearson, J. Greaves, D. Goodall, A. Berry, A. Richardson, G. O. Odundo, P. Omengo, P. Obonyo, N. M. Chanzu, R. Kleinpell, S. J. Sarris, P. Nedved, M. Heitschmidt, H. Ben-Ghezala, S. Snouda, S. Djobbi, N. K. J. Adhikari, D. Leasa, D. Fergusson, D. A. Mckim, J. Weblin, D. McWilliams, F. Doesburg, F. Cnossen, W. Dieperink, W. Bult, M. W. N. Nijsten, G. A. Galvez-Blanco, C. I. Olvera Guzman, J. Santos Stroud, R. Thomson, M. Llaurado-Serra, A. Lobo-Civico, M. Pi-Guerrero, I. Blanco-Sanchez, A. Piñol-Tena, C. Paños-Espinosa, Y. Alabart-Segura, B. Coloma-Gomez, A. Fernandez-Blanco, F. Braga-Dias, M. Treso-Geira, A. Valeiras-Valero, L. Martinez-Reyes, A. Sandiumenge, M. F. Jimenez-Herrera, CAPCRI Study, R. Prada, P. Juárez, R. Argandoña, J. J. Díaz, C. Sánchez Ramirez, P. Saavedra, S. Ruiz Santana, O. Obukhova, S. Kashiya, I. A. Kurmukov, A. M. Pronina, P. Simeone, L. Puybasset, G. Auzias, O. Coulon, B. Lesimple, G. Torkomian, A. Bartkowska-Sniatkowska, O. Szerkus, D. Siluk, J. Bartkowiak-Wieczorek, J. Rosada-Kurasinska, J. Warzybok, R. Kaliszan, C. Hernandez Caballero, S. Roberts, G. Isgro, D. Hall, G. Guillaume, O. Passouant, F. Dumas, W. Bougouin, B. Champigneulle, M. Arnaout, J. Chelly, J. D. Chiche, O. Varenne, J. P. Mira, E. Marijon, A. Cariou, M. Beerepoot, H. R. Touw, K. Parlevliet, C. Boer, P. W. Elbers, Á. J. Roldán Reina, Y. Corcia Palomo, R. Martín Bermúdez, L. Martín Villén, I. Palacios García, J. R. Naranjo Izurieta, J. B. Pérez Bernal, F. J. Jiménez Jiménez, Cardiac Arrest Group HUVR, F. Cota-Delgado, T. Kaneko, H. Tanaka, M. Kamikawa, R. Karashima, S. Iwashita, H. Irie, S. Kasaoka, O. Arola, R. Laitio, A. Saraste, J. Airaksinen, M. Pietilä, M. Hynninen, J. Wennervirta, M. Bäcklund, E. Ylikoski, P. Silvasti, E. Nukarinen, J. Grönlund, V. P. Harjola, J. Niiranen, K. Korpi, M. Varpula, R. O. Roine, T. Laitio, for the Xe-HYPOTHECA study group, S. Salah, B. G. Hassen, A. Mohamed Fehmi, Y. C. Hsu, J. Barea-Mendoza, C. García-Fuentes, M. Castillo-Jaramillo, H. Dominguez-Aguado, R. Viejo-Moreno, L. Terceros-Almanza, S. Bermejo Aznárez, C. Mudarra-Reche, W. Xu, M. Chico-Fernández, J. C. Montejo-González, K. Crewdson, M. Thomas, M. Merghani, L. Fenner, P. Morgan, D. Lockey, E. J. van Lieshout, B. Oomen, J. M. Binnekade, R. J. de Haan, N. P. Juffermans, M. B. Vroom, R. Algarte, L. Martínez, B. Sánchez, I. Romero, F. Martínez, S. Quintana, J. Trenado, O. Sheikh, D. Pogson, R. Clinton, F. Riccio, A. Arthur, L. Young, A. Sinclair, D. Markopoulou, K. Venetsanou, L. Filippou, E. Salla, S. Stratouli, I. Alamanos, A. H. Guirgis, R. Gutiérrez Rodriguez, M. J. Furones Lorente, I. Macias Guarasa, A. Ukere, S. Meisner, G. Greiwe, B. Opitz, D. Benten, B. Nashan, L. Fischer, C. J. C. Trepte, C. R. Behem, B. Ana, A. Vazir, D. Gibson, M. R. Hadavi, M. Riahi alam, M. R. Sasani, N. Parenti, F. Agrusta, C. Palazzi, B. Pifferi, R. Sganzerla, F. Tagliazucchi, A. Luciani, M. Möller, J. Müller-Engelmann, G. Montag, P. Adams, C. Lange, J. Neuzner, R. Gradaus, K. H. Wodack, F. Thürk, A. D. Waldmann, M. F. Grässler, S. Nishimoto, S. H. Böhm, E. Kaniusas, C. J. Trepte, M. Wallin, F. Suarez Sipman, A. Oldner, L. Colinas, R. Vicho, M. Serna, R. Cuena, A. Canabal, ECOCRITIC group, M. Etman, M. El Bahr, A. El Sakka, A. Arali, O. Bond, P. De Santis, E. Iesu, F. Franchi, S. Scolletta, F. S. Taccone, Z. Marutyan, L. Hamidova, A. Shakotko, V. Movsisyan, I. Uysupova, A. Evdokimov, S. Petrikov, F. J. Redondo Calvo, N. Bejarano, V. Baladron, R. Villazala, J. Redondo, D. Padilla, P. Villarejo, C. Gomez-Gonzalez, S. Mas-Font, A. Puppo-Moreno, M. Herrera-Gutierrez, M. Garcia-Garcia, S. Aldunate-Calvo, NEFROCON Investigators, E. P. Plata-Menchaca, X. L. Pérez-Fernández, M. Estruch, A. Betbese-Roig, P. Cárdenas Campos, M. Rojas Lora, N. D. Toapanta Gaibor, R. S. Contreras Medina, V. D. Gumucio Sanguino, E. J. Casanova, J. Sabater Riera, SIRAKI group, K. Kritmetapak, S. Peerapornratana, P. Kittiskulnam, T. Dissayabutra, P. Susantithapong, K. Praditpornsilpa, K. Tungsanga, S. Eiam-Ong, T. Winkelmann, T. Busch, J. Meixensberger, S. Bercker, E. M. Flores Cabeza, M. Sánchez Sánchez, N. Cáceres Giménez, C. Gutierrez Melón, E. Herrero de Lucas, P. Millán Estañ, M. Hernández Bernal, A. Garcia de Lorenzo y Mateos, P. A. C. Specht, M. Balik, M. Zakharchenko, F. Los, H. Brodska, C. de Tymowski, P. Augustin, M. Desmard, P. Montravers, S. N. Stapel, R. de Boer, H. M. Oudemans, A. Hollinger, T. Schweingruber, F. Jockers, M. Dickenmann, M. Siegemund, Clinical Intensive Care Research Basel, N. Runciman, L. Alban, C. Turrini, T. Sasso, T. Langer, P. Taccone, C. Marenghi, G. Grasselli, P. Wibart, T. Reginault, M. Garcia, B. Barbrel, A. Benard, C. Bader, F. Vargas, H. N. Bui, G. Hilbert, J. M. Serrano Simón, P. Carmona Sánchez, F. Ruiz Ferrón, M. García de Acilu, J. Marin, V. Antonia, L. Ruano, M. Monica, G. Hong, D. H. Kim, Y. S. Kim, J. S. Park, Y. K. Jee, Z. Yu xiang, W. Jia-xing, W. Xiao dan, N. Wen long, W. Yu, Z. Yan, X. Cheng, T. Kobayashi, Y. Onodera, R. Akimoto, A. Sugiura, H. Suzuki, M. Iwabuchi, M. Nakane, K. Kawamae, P. Carmona Sanchez, M. D. Bautista Rodriguez, M. Rodriguez Delgado, V. Martínez de Pinillos Sánchez, A. Mula Gómez, P. Beuret, C. Fortes, M. Lauer, M. Reboul, J. C. Chakarian, X. Fabre, B. Philippon-Jouve, S. Devillez, M. Clerc, N. Rittayamai, M. Sklar, M. Dres, M. Rauseo, C. Campbell, B. West, D. E. Tullis, M. Okada, N. Ahmad, M. Wood, A. Glossop, J. Higuera Lucas, A. Blandino Ortiz, D. Cabestrero Alonso, R. De Pablo Sánchez, L. Rey González, R. Costa, G. Spinazzola, A. Pizza, G. Ferrone, M. Rossi, G. Conti, H. Ribeiro, J. Alves, M. Sousa, P. Reis, C. S. Socolovsky, R. P. Cauley, J. E. Frankel, A. L. Beam, K. O. Olaniran, F. K. Gibbons, K. B. Christopher, J. Pennington, P. Zolfaghari, H. S. King, H. H. Y. Kong, H. P. Shum, W. W. Yan, C. Kaymak, N. Okumus, A. Sari, B. Erdogdu, S. Aksun, H. Basar, A. Ozcan, N. Ozcan, D. Oztuna, J. A. Malmgren, S. Lundin, K. Torén, M. Eckerström, A. Wallin, A. C. Waldenström, for the Section on Ethics of the ESICM, F. C. Riccio, A. C. P. Antonio, A. F. Leivas, F. Kenji, E. James, S. Jonnada, C. S. Gerrard, N. Jones, J. D. Salciccioli, D. C. Marshall, M. Komorowski, A. Hartley, M. C. Sykes, R. Goodson, J. Shalhoub, J. R. Fernández Villanueva, R. Fernández Garda, A. M. López Lago, E. Rodríguez Ruiz, R. Hernández Vaquero, C. Galbán Rodríguez, E. Varo Pérez, C. Hilasque, I. Oliva, G. Sirgo, M. C. Martin, M. Olona, M. C. Gilavert, M. Bodí, C. Ebm, G. Aggarwal, S. Huddart, N. Quiney, S. M. Fernandes, J. Santos Silva, J. Gouveia, D. Silva, R. Marques, H. Bento, A. Alvarez, Z. Costa Silva, D. Díaz Diaz, M. Villanova Martínez, E. Palencia Herrejon, A. Martinez de la Gandara, G. Gonzalo, M. A. Lopez, P. Ruíz de Gopegui Miguelena, C. I. Bernal Matilla, P. Sánchez Chueca, M. D. C. Rodríguez Longares, R. Ramos Abril, A. L. Ruíz Aguilar, R. Garrido López de Murillas, R. Fernández Fernández, P. Morales Laborías, M. A. Díaz Castellanos, M. E. Morales Laborías, J. Park, S. Woo, T. West, E. Powell, A. Rimmer, C. Orford, J. Williams, P. Ruiz de Gopegui Miguelena, R. S. Bourne, R. Shulman, M. Tomlin, G. H. Mills, M. Borthwick, W. Berry, D. García Huertas, F. Manzano, F. Villagrán-Ramírez, A. Ruiz-Perea, C. Rodríguez-Mejías, F. Santiago-Ruiz, M. Colmenero-Ruiz, C. König, B. Matt, A. Kortgen, C. S. Hartog, A. Wong, C. Balan, G. Barker, S. Tachaboon, J. Paratz, G. Kayambu, R. Boots, R. Vlasenko, E. Gromova, S. Loginov, M. Kiselevskiy, Y. Dolgikova, K. B. Tang, C. M. Chau, K. N. Lam, E. Gil, G. Y. Suh, C. M. Park, C. R. Chung, C. H. Lai, Y. J. Cheng, V. Colella, N. Zarrillo, M. D’Amico, F. Forfori, B. Pezza, T. Laddomada, V. Beltramelli, M. L. Pizzaballa, A. Doronzio, B. Balicco, D. Kiers, W. van der Heijden, J. Gerretsen, Q. de Mast, S. el Messaoudi, G. Rongen, M. Gomes, N. P. Riksen, Y. Kashiwagi, K. Hayashi, Y. Inagaki, S. Fujita, A. Blet, M. Sadoune, J. Lemarié, N. Bihry, R. Bern, E. Polidano, R. Merval, J. M. Launay, B. Lévy, J. L. Samuel, J. Hartmann, S. Harm, and V. Weber

Subjects
Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Published
2016
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36. Sharp wave ripple coupling in zebrafish hippocampus and basolateral amygdala

Author

I. Blanco, A. Caccavano, J. Wu, S. Vicini, E. Glasgow, and K. Conant

Abstract

The mammalian hippocampus exhibits sharp wave events (1-30 Hz) with an often-present superimposed fast ripple oscillation (120-200 Hz) forming a sharp wave ripple (SWR) complex. During slow wave sleep or consummatory behaviors, SWRs result from the sequential spiking of hippocampal cell assemblies initially activated during imagined or learned experiences. SWRs occur in tandem with cortical/subcortical assemblies critical to the long-term storage of specific memory types. Leveraging juvenile zebrafish, we show that SWR events in their hippocampal homologue, the anterodorsolateral lobe (ADL), inex vivowhole-brains are locally generated and maintained. SWR events were also recorded in the basolateral amygdala (BLA). Concomitant single cell calcium imaging and local field potential (LFP) recordings showed that BLA SWs couple to ADL SWs. Calcium imaging recordings of whole-brains demonstrated that ADL and BLA SWRs are endogenously and spontaneously silenced by the activation of a more caudal population of putative cholinergic cells. Electrical stimulation of this caudal region silenced ADL SWs. Our results suggest that the SWR-generating circuit is evolutionarily conserved through shared acetylcholine modulating mechanisms. These findings further our understanding of neuronal population dynamics in the zebrafish brain and highlights their advantage for simultaneously recording SW/SWRs and single cell activity in diverse brain regions.

Published
2023
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37. Imaging the Volcanic Structures Beneath Gran Canaria Island Using New Gravity Data

Author

F. G. Montesinos, J. Arnoso, D. Gómez‐Ortiz, M. Benavent, I. Blanco‐Montenegro, E. Vélez, T. Martín‐Crespo, A. V. Gorbatikov, and M. Y. Stepanova

Subjects
Geophysics, Space and Planetary Science, Geochemistry and Petrology, Geodesia, Earth and Planetary Sciences (miscellaneous), Geofísica
Abstract

From a new gravity data set that covers homogeneously the whole surface of Gran Canaria (Canary Islands, Spain) and marine gravity data in the nearest offshore, we have obtained a Bouguer anomaly gravity map of the island which improves the previous ones. Using these gravity anomalies, we have applied a gravity inversion approach to investigate the structures beneath the surface of Gran Canaria Island and derive a 3D gravity sources model. The geometry of structures with anomalous density values is constrained up to a depth of approximately 20,000 m below the sea level. The interpretation of the density model identified structures related to the different volcanic stages of Gran Canaria. Several deep-rooted high-density structures represent the intrusive bodies emplaced in the early formation of Gran Canaria and the magma plumbing system of the Miocene volcanic edifices. A low-density body in the center of the island may be associated with the syenitic core of the felsic central volcanic edifice (Tejeda Caldera). Shallow low-density structures identified fractures which acted as feeder dikes of monogenetic volcanoes during the rejuvenated stage. Finally, the NW-SE rift, which is the most important volcano-tectonic structure of Gran Canaria, has a characteristic gravimetric signature and represents a long-lived extensional fracture zone that has controlled the volcanic activity at least since the Miocene.

Published
2022
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38. Consenso de indicadores de calidad en la atención en colangiopancreatografía retrógrada endoscópica

Author

Claudia I. Blanco-Vela, Mario Peláez-Luna, Clara L. Martínez-García, Jordán Zamora-Godínez, Ángela Saúl-Pérez, Jony Cerna-Cardona, Enrique Murcio-Pérez, Claudia Martínez-Camacho, Aurelio López-Colombo, Fernando Pérez-Aguilar, Ana L. Desales-Iturbe, Fernando Rojas-Mendoza, Luis Mejía-Cuan, Héctor Espino-Cortés, Rodrigo Soto-Solís, María E. López-Acosta, Angélica Hernández-Guerrero, Ma del Carmen Manzano-Robleda, Juan O. Alonso-Larrága, Ariosto Hernández-Lara, Sergio Solana-Sentíes, Orlando Bada-Yllán, Joel O. Jáquez-Quintana, and Yolanda Zamorano-Orozco

Subjects
General Medicine
Published
2022
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39. The patient with Down syndrome and pulmonary arterial hypertension associated with congenital heart disease: from childhood to adulthood

Author

J Playan Escribano, E Garrido-Lestache, R Luna, M Alvarez Fuente, M Lopez-Meseguer, I Guillen Rodriguez, G M Perez Penate, A Sabate Rotes, T Elias Hernandez, M Lopez Ramon, J Rueda Soriano, F Perin, I Blanco, M J Del Cerro Marin, and P Escribano Subias

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Pulmonary arterial hypertension (PAH) is a common complication of congenital heart disease (CHD) that significantly affects its prognosis. Down syndrome is a common comorbidity among patients with PAH associated with CHD. Children born in recent years with CHD have benefited from advances in pediatric cardiac surgery that have modified their evolution compared to adults with the same pathologies. Our objective was to know and compare the characteristics of the adult and pediatric population with DS and PAH associated with CHD. REHAP and REHIPED are Spanish, voluntary, multicenter registries that include patients with PAH associated with CHD. REHAP started in 2007 and includes patients over 18 years of age. Patients diagnosed with PAH after this time were prospectively included, until 2021. Patients who were followed in the participating centers and diagnosed after January 1998 were retrospectively included in the registry. REHIPED started in 2009 and collects patients between 2 months and 18 years of age. Patients diagnosed with PAH after this time were prospectively included, until 2021. Patients who were followed and diagnosed after January 1998 were retrospectively included. 131 adults and 47 children with DS and PAH associated with CHD were analyzed. Their baseline characteristics, hemodynamics, treatment, and 10-year survival were compared. Adult patients with DS presented more frequently complete atrioventricular canal defect as underlying heart disease and were mostly in Eisenmenger's situation (84%). In pediatric patients the largest group was post-repair PAH (50%). Functional class was similar in both groups, although adults presented significantly greater hemodynamic severity. Regarding medical treatment, no differences were observed between both groups: there was a very low use of prostanoids both at baseline and at follow-up, and a majority use of oral monotherapy. There were no significant differences in survival. Corrective surgery in patients with DS has become more frequent over the years: adults are mostly in Eisenmenger's situation, while post-repair PAH is the most numerous group in children. Although adults show greater hemodynamic severity, survival is similar in both groups. Medical treatment, which showed no differences between pediatric and adult age, is very conservative, with most patients on oral monotherapy and rare use of prostanoids. Funding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Janssen MSD

Published
2022
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40. Ecuaciones de referencia de la capacidad aeróbica máxima ciclo-ergoespirometría para la población española adulta

Author

Felip Burgos, Luis Puente-Maestu, María Jesús Rodríguez-Nieto, Xavier Muñoz, Joaquim Gea, I. Blanco, Francisco García-Río, Julio Gómez-Seco, Julia García de Pedro, Francisco Ortega, Diego A. Rodríguez-Chiaradía, Batxi Galdiz, Iñigo Ojanguren, and Sociedad Española de Neumología y Cirugía Torácica

Subjects
Adult, Male, Pulmonary and Respiratory Medicine, Population, Adult population, Physical activity, Work rate, Prueba de ergometría en bicicleta, Young Adult, 03 medical and health sciences, Oxygen Consumption, 0302 clinical medicine, Bicycle ergometry test, Reference Values, Maximal WR, Maximal oxygen consumption, Cycle-ergometer, Consumo máximo de oxígeno, Humans, Cycle ergometer, Medicine, Aptitud física, education, Cardiopulmonary exercise test, Aged, Aged, 80 and over, education.field_of_study, Exercise Tolerance, business.industry, VO2 max, Cardiopulmonary exercise testing, General Medicine, Middle Aged, Physical fitness, Cicloergómetro, Pruebas de ejercicio cardiopulmonar, 030228 respiratory system, Cohort, Exercise Test, Female, business, Demography, Carga de trabajo máxima
Abstract

[EN] Background: Frequently used reference values for clinical exercise testing have been derived from non-random samples and some with poorly defined maximal criteria. Our objective was to obtain population based reference values for peak oxygen uptake ( ̇VO2 ) and work rate (WR) for cardiopulmonary exercise testing in a representative sample of Caucasian Spanish men and women. Methods: 182 men and women, 20–85 years old, were included and exercised on cycle-ergometer to exhaustion. ( ̇VO2 ) and WR were measured. The equations obtained from this sample were validated in an independent cohort of 69 individuals, randomly sampled form the same population. Then a final equation merging the two cohorts (=251) was produced. Results: Height, sex and age resulted predictive of both ̇VO2 peak and WR. Weight and physical activity added very little to the accuracy to the equations. The formulas ̇VO2 peak = 0.017 · height (cm) − 0.023 · age (years) + 0.864 · sex (female = 0/male = 1) ± 179 l min−1 , and peak WR = 1.345 · height (cm) − 2.074 · age (years) + 76.54 · sex (female = 0/male = 1) ± 21.2 W were the best compromise between accuracy and parsimony. Conclusions: This study provides new and accurate ̇VO2 peak and WR rate reference values for individuals of European Spanish descent, [ES] Antecedentes: Los valores de referencia utilizados con frecuencia para las pruebas de esfuerzo clínicas derivan de muestras no aleatorias y los criterios máximos para algunos de ellos están mal definidos. Nuestro objetivo fue obtener valores de referencia basados en la población general para el consumo máximo de oxígeno (VO 2 ) y la carga de trabajo (CT) para las pruebas de ejercicio cardiopulmonar a partir de una muestra representativa de varones y mujeres caucásicos españoles. Métodos: Se incluyeron 182 varones y mujeres, de entre 20 y 85 a ̃nos, que realizaron ejercicio en el cicloergómetro hasta el agotamiento. Se midieron el VO 2 y la CT. Las ecuaciones obtenidas de esta muestra se validaron en una cohorte independiente de 69 individuos, seleccionados aleatoriamente de la misma población. A continuación, se creó una ecuación final que fusionó las dos cohortes (n = 251). Resultados: La altura, el sexo y la edad resultaron predictivos tanto del ̇VO2 máximo como de la CT. El peso y la actividad física contribuyeron muy poco a la precisión de las ecuaciones. Las fórmulas ̇VO2 máximo = 0,017 × altura (cm) − 0,023 × edad (a ̃nos) + 0,864 × sexo (mujer = 0/varón = 1) ± 179 L × min−1 ; y CT máxima = 1,345 × altura (cm) − 2,074 × edad (a ̃nos) + 76,54 × sexo (mujer = 0/varón = 1) ± 21,2 W fueron el mejor equilibrio entre precisión y parsimonia. Conclusiones: Este estudio proporciona valores de referencia del ̇VO 2 máximo y la CT nuevos y precisos para personas de ascendencia espa ̃nola europea., This study was supported by a SEPAR (Sociedad Española de Neumología y Cirugía Torácica/Spanish society of Pulmonology and Thoracic Surgery) grant and NEUMOMADRD (Sociedad Madrileña de Neumología y Cirugía Torácica/Madrilenian Society of Pulmonology and Thoracic Surgery) research award.

Published
2021
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41. P114 SARS-CoV-2 infection in IBD: pandemic waves and predictors of severe or persistent COVID-19

Author

C Taxonera Samso, D Olivares, I Blanco, E Velasco, S Molina, G López, O N López-García, C Alba, and E Rey

Subjects
Gastroenterology, General Medicine
Abstract

Background This study aimed to compare the risk of COVID-19 in patients with IBD versus the general population, and to evaluate predictors of infection acquisition, progression to severe forms, and risk of developing persistent COVID-19. We also assess the differences between cases across the different COVID-19 pandemic waves in our target population. Methods This single-centre prospective, cohort study included consecutive IBD patients diagnosed of COVID-19 either by a positive polymerase chain reaction test and/or antigen test in nasopharyngeal swabs, or by anti-SARS-CoV-2 antibodies, and that they had a follow-up of at least 4 months. Using logistic regression, we evaluated cases versus IBD controls included in the IBD Unit database for predictors of COVID-19 acquisition. COVID-19 cases were distributed according to pandemic waves. Cox regression analysis was used for predictors of severe and persistent COVID-19. Results By May 31, 2021, 160 out of 1911 IBD patients (8.3%) were diagnosed with COVID-19. IBD patients had a similar adjusted incidence of COVID-19 (OR 0.94; 95% CI 0.86–1.02; P=0.42), and a similar associated mortality ratio (OR 0.83; 95% CI 0.6–1.06; P=0.48), compared to the general population. In multivariable analysis, treatment with biologics was associated with a higher risk (OR 2.22, P48 (HR 3.68, P=0.007), cases diagnosed in the first wave (HR 6.04, P Conclusion IBD patients have a similar risk of COVID-19 and associated mortality as the general population. Cases diagnosed during the first wave of the pandemic had severe and persistent forms of COVID-19 more frequently. Age and comorbidity were the main risk factors for severe forms of the disease.

Published
2022
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47. Baseline characteristics of patients included into the ERS Clinical Research Collaboration: 'Pulmonary Hemodynamics during Exercise - Research Network' (PEX-NET) registry

Author

G Kovacs, M Humbert, P Herve, A Avian, N Galie, G Lewis, R Souza, S Ulrich, A Vonk Noordegraaf, M Andersen, J A Barbera, I Blanco, R Condliffe, M D'Alto, B Egenlauf, R Ewert, E Gruenig, A Heine, S Herkenrath, S Hsu, K Kasperowicz, S Mak, B Maron, C Mccabe, R Oliveira, S Rosenkranz, L Savale, S Saxer, D Systrom, R Tedford, A Torbicki, and H Olschewski

Published
2022
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48. Irrigation efficiency and water-policy implications for river basin resilience

Author

C. A. Scott, S. Vicuña, I. Blanco-Gutiérrez, F. Meza, and C. Varela-Ortega

Subjects
Technology, Environmental technology. Sanitary engineering, TD1-1066, Geography. Anthropology. Recreation, Environmental sciences, GE1-350
Abstract

Rising demand for food, fiber, and biofuels drives expanding irrigation withdrawals from surface water and groundwater. Irrigation efficiency and water savings have become watchwords in response to climate-induced hydrological variability, increasing freshwater demand for other uses including ecosystem water needs, and low economic productivity of irrigation compared to most other uses. We identify three classes of unintended consequences, presented here as paradoxes. Ever-tighter cycling of water has been shown to increase resource use, an example of the efficiency paradox. In the absence of effective policy to constrain irrigated-area expansion using "saved water", efficiency can aggravate scarcity, deteriorate resource quality, and impair river basin resilience through loss of flexibility and redundancy. Water scarcity and salinity effects in the lower reaches of basins (symptomatic of the scale paradox) may partly be offset over the short-term through groundwater pumping or increasing surface water storage capacity. However, declining ecological flows and increasing salinity have important implications for riparian and estuarine ecosystems and for non-irrigation human uses of water including urban supply and energy generation, examples of the sectoral paradox. This paper briefly considers three regional contexts with broadly similar climatic and water-resource conditions – central Chile, southwestern US, and south-central Spain – where irrigation efficiency directly influences basin resilience. The comparison leads to more generic insights on water policy in relation to irrigation efficiency and emerging or overdue needs for environmental protection.

Published
2014
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49. Actualización sobre el uso de estándares de crecimiento de la Organización Mundial de la Salud en la red de atención primaria de Rosario

Author

Yanina Sguassero, Guillermina B Harvey, and Virginia I. Blanco

Abstract

Objetivo: a más de 10 años del cambio del patrón de referencia del crecimiento infantil en argentina, se realizó un estudio para conocer el estado de implementación de los estándares de crecimiento de 0 a 5 años de la organización mundial de la salud en atención primaria de la salud. Métodos: estudio transversal realizado en la ciudad de rosario, santa fe (mayo 2018—mayo 2019). Se enviaron encuestas en línea a médicos pediatras y generalistas, y se entrevistaron a informantes clave. Los ejes de indagación fueron: valoración de la herramienta, estrategias de capacitación, e intervenciones para promover el uso e interpretación. El análisis fue cuali—cuantitativo. Resultados: se completaron 95 encuestas y se realizaron ocho entrevistas. La adopción de los estándares oms fue considerado un cambio favorable para la argentina. Las intervenciones de valoradas como de mayor utilidad para optimizar el uso de los estándares de la organización mundial de la salud por los médicos encuestados fueron: mantenimiento de los equipos para mediciones antropométricas, promoción de consejería nutricional e impresión de gráficas de crecimiento para uso individual. Las diferencias de opinión entre los médicos de los centros de salud y quienes ocupan un cargo en gestión estuvieron dadas por la factibilidad de algunas intervenciones en atención primaria de la salud. Conclusión: existen estrategias tendientes a favorecer la implementación de intervenciones valoradas por los médicos de la red de atención primaria que permitirían un mayor aprovechamiento de los estándares de la organización mundial de la salud.

Published
2021
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50. Neoplasia intraepitelial vulvar: Cribado en población de riesgo

Author

I. Blanco Herraez, C. Álvarez Gil, C. Redondo Guisasola, L. Pineda Domínguez, R. Sanz Baro, and I.M. Ferreira Borrego

Subjects
0301 basic medicine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Reproductive Medicine, business.industry, 030220 oncology & carcinogenesis, Obstetrics and Gynecology, Medicine, business, Humanities
Abstract

Resumen Antecedentes Las pacientes con neoplasias cervicales intraepiteliales (CIN) tienen mayor riesgo de desarrollar lesiones causadas por el virus del papiloma humano (VPH) en otras localizaciones del tracto genital inferior (entre ellas, la vulva). La vulvoscopia no esta incluida en el seguimiento de las mujeres con CIN. Se propone estudiar la eficiencia de incluir la vulvoscopia en dicho seguimiento. Se analiza tambien la incidencia de la displasia vulvar de alto grado y la influencia de los factores protectores y de riesgo. Material y metodos Se incluyeron 95 pacientes con diagnostico de CIN (en pieza de conizacion). Se recogio toda la informacion relativa a sus caracteristicas sociodemograficas y clinicas; se realizo vulvoscopia y, eventualmente, biopsia. Resultados y conclusiones La media de edad de las pacientes fue de 40 anos. El 62,1% de ellas eran o habian sido fumadoras (mas de la mitad habian abandonado el habito tabaquico en el momento del estudio). Solo el 21,1% declararon no utilizar metodo de barrera. Aunque el 78,9% de las estudiadas eran o habian sido usuarias de anticoncepcion hormonal, solo ocho de ellas seguian utilizandola. Ochenta y ocho de las 95 mujeres (92,6%) estaban vacunadas contra el VPH (la mayoria postconizacion). No se diagnostico ninguna displasia vulvar de alto grado. La modificacion en el estilo de vida tras el diagnostico de la patologia cervical, la transitoriedad de la infeccion por el VPH y la mayor susceptibilidad del epitelio cervical a esta, se nos muestran como las causas mas probables de la discordancia entre la prevalencia de la patologia vulvar esperada y la encontrada en la poblacion estudiada.

Published
2021
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