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11. Respect, Cultural Sensitivity, and Communication: Promoting Participation by Asian Families in the Individualized Family Service Plan.

Author

Hyun, Jinhee K. and Fowler, Susan A.

Abstract

Specific suggestions are offered to promote the participation of Asian families of young, special-needs children in the Individualized Family Service Plan (IFSP) process. Suggestions address: enhancing one's own cultural awareness, overcoming language differences, holding effective family conferences, and developing family outcomes in the IFSP. (DB)

Published
1995

12. COVID-19 and Risk Factors of Anxiety and Depression in South Korea

Author

Hyun, Jinhee, primary, Kim, Seokjoo, additional, Kim, Heeguk, additional, Choi, Yun-Jung, additional, Choi, Yun-Kyeung, additional, Lee, Yu-Ri, additional, Paik, Jong-Woo, additional, Lee, Jong-Sun, additional, Kim, Kihyun, additional, Jun, Jin Yong, additional, Lee, So Hee, additional, and Sohn, Sunju, additional

Published
2021
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13. Older adults and care: reshaped family roles in societal change : A comparative study of Japan, South Korea, and Sweden

Author

Anbäcken, Els-Marie, Almqvist, Anna-Lena, Johansson, Carl, Kinugasa, Kazushige, Obata, Miho, Hyun, Jinhee, Lee, Jinsook, Park, Young Joon, Anbäcken, Els-Marie, Almqvist, Anna-Lena, Johansson, Carl, Kinugasa, Kazushige, Obata, Miho, Hyun, Jinhee, Lee, Jinsook, and Park, Young Joon

Abstract

Purpose: The aim is to explore how family relations are affected by societal changes in relation to informal and formal caregiving and self-determination of older adults. Design/methodology/approach: Care managers (CMs)/social workers (SWs) (N = 124) participated in a comparative vignette study including Japan, South Korea, and Sweden. Systems theory was used. Findings: Japanese CMs/SWs clearly describe their efforts to create networks in a relational way between formal and informal actors in the community. South Korean CMs/SWs balance between suggesting interventions to support daily life at home or a move to a nursing home, often acknowledging the family as the main caregiver. In Sweden, CMs/SWs highlight the juridical element in meeting the older adult and the interventions offered, and families primarily give social support. Regarding self-determination, the Japanese priority is for CMs/SWs to harmonize within the family and the community. South Korean CMs/SWs express ambivalent attitudes to older adults’ capability for self-determination in the intersection between formal and family care. Swedish CMs/SWs adhere to the older adult’s self-determination, while acknowledging the role of the family in persuading the older adult to accept interventions. The results suggest emerging defamilialization in South Korea, while tendencies to refamilialization are noticed in Japan and Sweden, albeit in different ways. Research limitations/implications: In translation, nuances may be lost. A focus on changing families shows that country-specific details in care services have been reduced. For future research, perspectives of “care” need to be studied on different levels. Originality/value: Using one vignette in three countries with different welfare regimes, discussing changing views on families’, communities’ and societal caregiving is unique. This captures changes in policy, influencing re- and defamilialization.

Published
2021
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18. Psychosocial Support during the COVID-19 Outbreak in Korea: Activities of Multidisciplinary Mental Health Professionals

Author

Hyun, Jinhee, primary, You, Sungeun, additional, Sohn, Sunju, additional, Kim, Seok-Joo, additional, Bae, Jeongyee, additional, Baik, Myungjae, additional, Cho, In Hee, additional, Choi, Hyunjung, additional, Choi, Kyeong-Sook, additional, Chung, Chan-Seung, additional, Jeong, Chanyoung, additional, Joo, Hyesun, additional, Kim, Eunji, additional, Kim, Heeguk, additional, Kim, Hyun Soo, additional, Ko, Jinsun, additional, Lee, Jung Hyun, additional, Lee, Sang Min, additional, Lee, So Hee, additional, and Chung, Un Sun, additional

Published
2020
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21. HIV and HCV augments inflammatory responses through increased TREM-1 expression and signaling in Kupffer and Myeloid cells

Author

Hyun, Jinhee, primary, McMahon, Robert S., additional, Lang, Anna L., additional, Edwards, Jasmine S., additional, Badilla, Alejandro Dmitar, additional, Greene, Morgan E., additional, Stone, Geoffrey W., additional, Pallikkuth, Suresh, additional, Stevenson, Mario, additional, Dykxhoorn, Derek M., additional, Kottilil, Shyam, additional, Pahwa, Savita, additional, and Thomas, Emmanuel, additional

Published
2019
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25. Human intestinal epithelial cells express IL-10 through Toll-like receptor 4 (TLR4)-mediated epithelial-macrophage crosstalk

Author

Hyun, Jinhee, Romero, Laura, Riveron, Reldy, Flores, Claudia, Kanagavelu, Saravana, Chung, Kristina D., Alonso, Ana, Sotolongo, John, Ruiz, Jose, Manukyan, Armine, Chun, Sally, Singh, Gaurav, Pedro, Salas, Targan, Stephan R., and Fukata, Masayuki

Subjects
MAP Kinase Signaling System, Prostaglandin D2, Macrophages, Epithelial Cells, Cell Communication, digestive system, Article, Gene Expression Regulation, Enzymologic, Interleukin-10, Toll-Like Receptor 4, Cyclooxygenase 2, Humans, Intestinal Mucosa, Cells, Cultured
Abstract

In the intestine, interaction between epithelial cells and macrophages (MΦs) create a unique immunoregulatory microenvironment necessary to maintain local immune and tissue homeostasis. Human intestinal epithelial cells (IECs) have been shown to express interleukin (IL)-10, which keeps epithelial integrity. We have demonstrated that bacterial signaling through Toll-like receptor (TLR) 4 induces 15-deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) synthesis in intestinal MΦs by cyclooxygenase (Cox)-2 expression. Here, we show that TLR4 signaling generates crosstalk between IECs and MΦs that enhances IL-10 expression in IECs. Direct stimulation of TLR4 leads to the expression of IL-10 in IECs, while the presence of MΦs in a Transwell system induces another peak in IL-10 expression in IECs at a later time point. The second peak of the IL-10 expression is two times greater than the first peak. This late induction of IL-10 depends on the nuclear receptor peroxisome proliferator-activated receptor (PPAR) γ that is accumulated in IECs by TLR4-mediated inhibition of the ubiquitin-proteasomal pathway. TLR4 signaling in MΦs in turn synthesizes 15d-PGJ2 through p38 and ERK activation and Cox-2 induction, which activates PPARγ in IECs. These results suggest that TLR4 signaling maintains IL-10 production in IECs by generating epithelial-MΦs crosstalk, which is an important mechanism in the maintenance of intestinal homeostasis mediated through host-bacterial interactions.

Published
2014

32. Human Intestinal Epithelial Cells Express Interleukin-10 through Toll-Like Receptor 4-Mediated Epithelial-Macrophage Crosstalk

Author

Hyun, Jinhee, primary, Romero, Laura, additional, Riveron, Reldy, additional, Flores, Claudia, additional, Kanagavelu, Saravana, additional, Chung, Kristina D., additional, Alonso, Ana, additional, Sotolongo, John, additional, Ruiz, Jose, additional, Manukyan, Armine, additional, Chun, Sally, additional, Singh, Gaurav, additional, Salas, Pedro, additional, Targan, Stephan R., additional, and Fukata, Masayuki, additional

Published
2014
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38. TIR-Domain-Containing Adapter-Inducing Interferon- β (TRIF) Regulates CXCR5+ T helper Cells in the Intestine.

Author

Kanagavelu S, Flores C, Hagiwara S, Ruiz J, Hyun J, Cho EE, Sun F, Romero L, Shih DQ, and Fukata M

Abstract

Objective: Establishing an effective humoral immunity is an important host defense mechanism in intestinal mucosa. T follicular helper (Tfh) cells are a spectrum of CXCR5 expressing T helper cells that induce antigen-specific B cell differentiation. Because the differentiation of T helper cells is largely regulated by innate immunity, we addressed whether TRIF signaling regulates Tfh cell differentiation and its ability to trigger humoral immune responses in the intestine., Method: CD4 + CXCR5 + T cells, B cells, and plasma cells in the Peyer's patches (PPs) of WT and TRIF-deficient (Trif LPS2 ) mice were analyzed by flow cytometry at the baseline, 9 days post primary infection, and 7 days post-secondary infection with Y. enterocolitica . Y. enterocolitica -specific CD4 + CXCR5 + T cells were generated in vitro by co-culturing peritoneal macrophages with splenic naïve T cells in the presence of Y. enterocolitica lysate. WT and Trif LPS2 mice received CD4 + CXCR5 + T cells isolated either from Y. enterocolitica -primed WT mice or generated in vitro . These mice were infected with Y. enterocolitica and followed up to 4 weeks. Y. enterocolitica -specific IgA and IgG were measured in stool and serum samples, respectively., Results: At baseline, CD4 + CXCR5 + T cell proportion was higher but the proportion of B cells and plasma cells was lower in the PPs of Trif LPS2 mice compared to WT mice. After infection, the proportion of plasma cells also became higher in the PPs of Trif LPS2 mice compared to WT mice. Corresponding increase of Y. enterocolitica -specific stool IgA but not serum IgG was found in Trif LPS2 mice compared to WT mice. Both in vivo isolated and in vitro generated CD4 + CXCR5 + T cells induced protective immunity against Y. enterocolitica infection., Conclusion: Our results reveal a novel role of TRIF in the regulation of humoral immunity in the intestine that can be utilized as a basis for a unique vaccine strategy., Competing Interests: The authors have no conflicts of interest to disclose.

Published
2016
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39. Human intestinal epithelial cells express interleukin-10 through Toll-like receptor 4-mediated epithelial-macrophage crosstalk.

Author

Hyun J, Romero L, Riveron R, Flores C, Kanagavelu S, Chung KD, Alonso A, Sotolongo J, Ruiz J, Manukyan A, Chun S, Singh G, Salas P, Targan SR, and Fukata M

Subjects
Cells, Cultured, Cyclooxygenase 2 immunology, Gene Expression Regulation, Enzymologic immunology, Humans, Prostaglandin D2 analogs & derivatives, Prostaglandin D2 immunology, Cell Communication immunology, Epithelial Cells immunology, Interleukin-10 immunology, Intestinal Mucosa immunology, MAP Kinase Signaling System immunology, Macrophages immunology, Toll-Like Receptor 4 immunology
Abstract

In the intestine, interaction between epithelial cells and macrophages (MΦs) create a unique immunoregulatory microenvironment necessary to maintain local immune and tissue homeostasis. Human intestinal epithelial cells (IECs) have been shown to express interleukin (IL)-10, which keeps epithelial integrity. We have demonstrated that bacterial signaling through Toll-like receptor (TLR) 4 induces 15-deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) synthesis in intestinal MΦs by cyclooxygenase (Cox)-2 expression. Here, we show that TLR4 signaling generates crosstalk between IECs and MΦs that enhances IL-10 expression in IECs. Direct stimulation of TLR4 leads to the expression of IL-10 in IECs, while the presence of MΦs in a Transwell system induces another peak in IL-10 expression in IECs at a later time point. The second peak of the IL-10 expression is two times greater than the first peak. This late induction of IL-10 depends on the nuclear receptor peroxisome proliferator-activated receptor (PPAR) γ that is accumulated in IECs by TLR4-mediated inhibition of the ubiquitin-proteasomal pathway. TLR4 signaling in MΦs in turn synthesizes 15d-PGJ2 through p38 and ERK activation and Cox-2 induction, which activates PPARγ in IECs. These results suggest that TLR4 signaling maintains IL-10 production in IECs by generating epithelial-MΦs crosstalk, which is an important mechanism in the maintenance of intestinal homeostasis mediated through host-bacterial interactions., (© 2014 S. Karger AG, Basel.)

Published
2015
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