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Objectives: To assess malignant transformation rate, non‐sinonasal malignancies, and factors contributing to recurrence in patients treated for sinonasal inverted papilloma (SNIP). Study Design: Retrospective study. Methods: We retrospectively reviewed medical records of all patients treated for SNIP (n = 296) between the years 1984–2014 at Helsinki University Hospital. Data from the Finnish Cancer Registry confirmed the number of those patients with sinonasal and non‐sinonasal malignancies. Results: Only 2 of 296 (0.7%) patients primarily diagnosed with benign SNIP developed sinonasal cancer in a mean follow‐up of 5.8 years. The most common non‐sinonasal cancer sites were similar to those reported for the whole Finnish population. None of the patients presented with an HPV‐associated non‐sinonasal malignancy. The recurrence rate among patients who underwent attachment‐oriented surgery was significantly lower compared to those operated on with other approaches (40.2% vs. 56.6%, p = 0.006). Dysplasia in SNIP was associated with a higher recurrence rate (p < 0.001). Conclusions: Malignant transformation of SNIP was rare. Patients with SNIP were not prone to HPV‐associated non‐sinonasal malignancies. Endoscopic resection and attachment‐oriented surgery have become predominant approaches in the treatment of SNIP; meanwhile, the total number of SNIP recurrences has decreased. Level of Evidence: 3 Laryngoscope, 133:506–511, 2023 [ABSTRACT FROM AUTHOR]

Objectives: The present study aimed to evaluate human papillomavirus (HPV) occurrence in sinonasal inverted papilloma (SNIP), and to assess factors associated with HPV positivity and SNIP recurrence. Study Design: Prospective study. Methods: We prospectively collected clinical data and fresh tissue specimens from 90 consecutive patients treated for SNIP at Helsinki University Hospital, between 2015 and 2019. Fourteen patients with recurrent SNIP underwent repeated tumor sampling. All tissue specimens were analyzed for the presence of HPV. Factors associated with SNIP recurrence and HPV positivity were assessed. Results: Among 107 SNIP specimens, 14 (13.1%) were positive for low‐risk HPV and 6 (5.6%) were positive for high‐risk HPV. HPV positivity was associated with an increased risk of recurrence (P =.004). Smoking was significantly associated with HPV positivity in SNIP (P =.01), but a history of HPV‐related diseases or patient sexual habits did not correlate with HPV positivity. The recurrence rate was lower among patients with SNIP that underwent an attachment‐oriented resection, compared to patients treated without attachment‐oriented resections (78.6% vs 25.8%, P <.001). Conclusions: The risk of SNIP recurrence was highly associated with 1) HPV positivity and 2) surgery without an attachment‐oriented resection. Oncogenic HPV was rare in SNIP. Level of Evidence: 3 Laryngoscope, 132:1714–1718, 2022 [ABSTRACT FROM AUTHOR]

Objectives: Postoperative infection is the most common complication after septoplasty. Pre‐ or postoperative prophylactic antibiotics are commonly used, although no official guidelines exist. Design: We retrospectively collected data on postoperative infections from 772 septoplasties performed in 2015, 2016 and 2018, and classified the infections according to surgical site infection (SSI) criteria by the Centers for Disease Control and Prevention (CDC). We evaluated the infections according to antibiotic use (preoperative or postoperative, both, or none) and accounted for patient and surgical confounding factors. We compared the results with three previous studies from our department to find out the trend in the occurrence of postoperative infections and in the use of antibiotics. Results: Twenty‐nine cases (3.8%) fulfilled CDC infection criteria. Any kind of antibiotic prophylaxis reduced the risk of SSI (p =.018). One dose of intravenous cefuroxime before incision was the most effective preventive measure (p =.045). We found no significant effect of postoperative antibiotics. However, postoperative antibiotics lowered the infection rate to 1.8% compared to 6.1% among those not treated with any antibiotics. The only other factor reducing the risk of SSI was local anaesthesia compared with general anaesthesia. Conclusion: Preoperative antibiotic prophylaxis effectively reduced postoperative infection rate after septoplasty. [ABSTRACT FROM AUTHOR]

Conclusion:In terms of operation time, anesthesia method, and low complication rate, ESS and balloon sinuplasty seemed comparable. The advantages of balloon sinuplasty were shown to be shortness of sick leave, possibility to be performed as an in-office procedure, and lower adhesion formation. Background:Endoscopic sinus surgery (ESS) has been considered as a treatment of choice for persistent chronic rhinosinusitis (CRS). During the last decade balloon sinuplasty has been introduced as an alternative technique to dilate the ostium. Although balloon sinuplasty is considered relatively safe and efficient, comparative evidence of its putative intra-operative and post-operative advantages remain limited. Objectives:The aim of this retrospective controlled study was to evaluate intra-operative factors and early post-operative outcomes among CRS patients who had undergone maxillary sinus operation with either balloon sinuplasty or ESS technique. Materials and methods:Data were collected from 208 patients with CRS treated either with ESS or balloon sinuplasty during the years 2008–2010. Intra- and peri-operative factors were collected from patient records of the patients who met the inclusion criteria (n = 39 in ESS group andn = 36 in balloon sinuplasty group). Results:There was no significant difference in operation time and anesthesia method between the two groups. No complications occurred with either technique. All ESS procedures and 67% of the balloon sinuplasty procedures were done in the hospital setting, whereas 33% of the balloon sinuplasty procedures were done in the office setting. The duration of sick leave and the number of patients with adhesions were significantly higher in the ESS group compared to the balloon sinuplasty group. [ABSTRACT FROM PUBLISHER]