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2. List of contributors

Author

Abalo, Raquel, primary, Abdelghffar, Eman A., additional, Abdelkhalek, Yasmin M., additional, Acuña, Sabrina, additional, Adeyemo, Oluwatobi, additional, Ahlawat, Jyoti, additional, Ahmad, Aftab, additional, Ahsan, Khansa, additional, Ajeigbe, Olufunke Florence, additional, Alberto-Silva, Carlos, additional, Ali, Javed, additional, Almeida, Carlos Gabriel Moreira, additional, Almeida, Áurea Maria Alves Nunes, additional, Alves, Anna Beatriz Pereira Simões, additional, Anamelechi, Joy, additional, Andreatini, R., additional, Arbo, Bruno Dutra, additional, Arent, Camila O., additional, Ashraf, Hagar, additional, Aslim, Belma, additional, Atarase, Oyepeju, additional, Awasthi, Rajendra, additional, Baboota, Sanjula, additional, Bagatini, Margarete Dulce, additional, Bakrim, Saad, additional, Barajas-Saucedo, C.E., additional, Bassols, Anna, additional, Batagin-Neto, Augusto, additional, Benameur, Tarek, additional, Bermúdez-Guzmán, M.J., additional, Bernardi, María Alejandra, additional, Bertollo, Amanda Gollo, additional, Beulaja, M., additional, Bhattacharya, Pallab, additional, Binda, Nancy Scardua, additional, Bisagno, Verónica, additional, Boeira, Silvana Peterini, additional, Bonjorno, Andressa Francielli, additional, Borah, Anupom, additional, Borsini, Alessandra, additional, Botelho, Maria Eduarda M., additional, Boudreau, Luc H., additional, Bouyahya, Abdelhakim, additional, Brimson, James Michael, additional, Bujtor, Melissa, additional, Büsselberg, Dietrich, additional, Butt, Arthur Morgan, additional, Čagalj, Martina, additional, Candeias, Emanuel, additional, Cardoso, Sandra Morais, additional, Carlini, Celia R., additional, Carrazoni, Thiago, additional, Carreira, Rodrigo Barreto, additional, Carrera-González, María Pilar, additional, Castro e Silva, Juliana Helena, additional, Catherene, M. Livya, additional, Chamorro, María E., additional, Charlotte, Lechevallier, additional, Chaudhary, Antra, additional, Chiba, Diego Eidy, additional, Choonara, Yahya E., additional, Chukwudozie, Kingsley Ikechukwu, additional, Convertini, Paolo, additional, Correa, Florencia, additional, Costa, Silvia Lima, additional, Cox, Paul Alan, additional, Crispi, Stefania, additional, Cuciniello, Rossana, additional, urko-Cofek, Božena, additional, da Cunha, Israel Cordeiro Eller, additional, da Rocha Fernandes, Livia, additional, da Silva, Gilnei Bruno, additional, da Silva, Juliana Figueira, additional, da Silva, Victor Diogenes Amaral, additional, Dakka, Nadia, additional, Dal Belo, Cháriston André, additional, Datta, Aishika, additional, de Almeida, Monique Marylin Alves, additional, de Araújo, Fillipe Mendes, additional, de Bari, Lidia, additional, de Faria Lopes, Giselle Pinto, additional, de Gomes, Marcelo Gomes, additional, de Oliveira, Juciele Valéria Ribeiro, additional, de Oliveira, Marcos Roberto, additional, de Oliveira, Êndel Alves Gomes, additional, de Sampaio Schitine, Clarissa, additional, de Souza, Suzana Braga, additional, de Souza, Veronica Moreira, additional, Del Fabbro, Lucian, additional, Dhiman, Neerupma, additional, Di Meo, Francesco, additional, Dias Costa, Maria de Fatima, additional, do Nascimento, Ravena Pereira, additional, Dora, Cristiana Lima, additional, dos Santos, Balbino Lino, additional, dos Santos, Cleonice Creusa, additional, dos Santos, Jean Leandro, additional, dos Santos, Michele Goulart, additional, Dourado, Naiara Silva, additional, El Idrissi, Abdeslem, additional, El Menyiy, Naoual, additional, Eldahshan, Omayma A., additional, El-Nashar, Heba A.S., additional, El-Shazly, Mohamed, additional, Empadinhas, Nuno, additional, Esteban, S., additional, Esteves, A. Raquel, additional, Ezenandu, Emmanuel Obinna, additional, Ezeorba, Timothy Prince Chidike, additional, Ezeudoka, Brendan Chukwuemeka, additional, Fagiolino, Pietro, additional, Farombi, Ebenezer O., additional, Ferreira, Rafael Short, additional, Finnie, John W., additional, Furian, Ana Flávia, additional, Gaitán-Hinojosa, M.A., additional, Galván-Hernández, A.R., additional, García-Villalvazo, P.E., additional, Garg, Chahat, additional, Gazerani, Parisa, additional, Ghosh, Bijoyani, additional, Gomez, Marcus Vinícius, additional, González-Bulnes, Antonio, additional, Goyal, Lav, additional, Grewal, Amarjot Kaur, additional, Grubi Kezele, Tanja, additional, Guedes, Beatriz, additional, Guevara, Natalia, additional, Gutierrez, Antonia, additional, Habtemariam, Solomon, additional, Haghdoost-Yazdi, Hashem, additional, Hassoun, Abdo, additional, Heidari, Reza, additional, Hernández-González, Ignacio, additional, Horn, Ana Paula, additional, Hort, Mariana Appel, additional, Hritcu, Lucian, additional, Hyslop, Stephen, additional, Ibarra-Vega, R., additional, Ignácio, Zuleide Maria, additional, Ikeji, Cynthia Nwamaka, additional, Infantino, Vittoria, additional, James, Adewale Segun, additional, Jauquet, Mélissa, additional, Jimenez-García, M., additional, Jiménez-Vargas, J.M., additional, Junge, Stephanie, additional, Kalapos, Miklós Péter, additional, Kalra, Palak, additional, Kanazawa, L.K.S., additional, Kanekar, Shami, additional, Kargieman, Lucila, additional, Kaur, Jasleen, additional, Kaushik, Medha, additional, Kaushik, Pooja, additional, Khan, Farha Deeba, additional, Kharkwal, Harsha, additional, Komane, Patrick P., additional, Kubatka, Peter, additional, Kulkarni, G.T., additional, Kumar, Pradeep, additional, Kumar, Shobhit, additional, la Torre, Maria Ester, additional, Lahyaoui, Manal, additional, Lefebvre, Kathi A., additional, Leite, José Roberto S.A., additional, Lemarchand, Eloïse, additional, Lino-López, G.J., additional, Lopes, Flávia Garcia, additional, Lopes, Juliana Romano, additional, Lopez del Castillo, Ines, additional, López-Gómez, Laura, additional, Loureiro, Joana, additional, Luhach, Kanishk, additional, Magalhães, João Duarte, additional, Mahalakshmi, K., additional, Malar, Dicson Sheeja, additional, Maldonado, Cecilia, additional, Maltaneri, Romina E., additional, Manikandan, R., additional, Manosso, Luana M., additional, Marciniak, Stefan J., additional, Marín-Prida, Javier, additional, Marques, Magno da Silva, additional, Martínez-Martos, José Manuel, additional, Martyniuk, Christopher J., additional, Matosinhos, Rafaela Cunha, additional, Maurya, Shashank Kumar, additional, Melo-Marques, Inês, additional, Messina, Antonietta, additional, Messina, Giovanni, additional, Metcalf, James S., additional, Mihaiela, Cornea-Cipcigan, additional, Miralles, A., additional, Mishra, Rajeev, additional, Mishra, Rajnikant, additional, Monda, Marcellino, additional, Monda, Vincenzo, additional, Moranta, D., additional, Moreira, Daniel C., additional, Moreno-Gonzalez, Ines, additional, Morin, Pier, additional, Munawar, Nayla, additional, Naqvi, Saba, additional, Nedel, Cláudia Beatriz, additional, Nelissen, E., additional, Nesse, Alcira B., additional, Nigdelioglu Dolanbay, Serap, additional, Nunes-Costa, Daniela, additional, Ojo, Mercy Olubunmi, additional, Okeke, Emmanuel Sunday, additional, Okoye, Charles Obinwanne, additional, Okoye, Henrietta Ukamaka, additional, Oliveira, R.M.W., additional, Oliveira, Raquel Soares, additional, Ommati, Mohammad Mehdi, additional, Onaolapo, Adejoke Y., additional, Onaolapo, Olakunle J., additional, Panaro, Maria Antonietta, additional, Pappalardo, Ilaria, additional, Parimalanandhini, D., additional, Parvez, Suhel, additional, Patel, Mayank, additional, Pavan, Aline Renata, additional, Pedro, Lucas C., additional, Pentón-Rol, Giselle, additional, Pereira, Erica Patrícia, additional, Pereira-Santos, A. Raquel, additional, Pérez-Valle, Jorge, additional, Perissinotti, Paula P., additional, Phadke, Girija Gajanan, additional, Piermartiri, Tetsade C.B., additional, Pinto, João Victor Krüger, additional, Pizzolorusso, Ilaria, additional, Polito, Rita, additional, Porro, Chiara, additional, Portaro, Fernanda Calheta Vieira, additional, Prasad, K.V.S.R.G., additional, Prasanth, Mani Iyer, additional, Prickaerts, J., additional, Prokai, Laszlo, additional, Prokai-Tatrai, Katalin, additional, Quevedo, João, additional, Rabbani, Syed Arman, additional, Raj, Khadga, additional, Ramírez-Expósito, María Jesús, additional, Ramis, M.R., additional, Rana, Nikita, additional, Rathod, Nikheel Bhojraj, additional, Rawat, Kajal, additional, Retana-Marquez, Socorro, additional, Réus, Gislaine Z., additional, Ribeiro, Paulo Roberto, additional, Ríos-Bracamontes, E.F., additional, Rivero-Echeto, María Celeste S., additional, Rodica, Mrgoan, additional, Rodríguez-Leone, Nazarena, additional, Roussel, Benoit D., additional, Ruggiero, Melania, additional, Rupasree, P., additional, Saha, Lekha, additional, Salau, Veronica F., additional, Sangeetha, R., additional, Sardana, Satish, additional, Sarduy-Chávez, Rocío de la Caridad, additional, Sarmah, Deepaneeta, additional, Sarubbo, F., additional, Schimith, Lucia Emanueli, additional, Shahidul Islam, Md., additional, Sharika, Rajasekharan, additional, Sharma, Bhupesh, additional, Sharma, Poonam, additional, Sharma, Shrestha, additional, Shrivastava, Rahul, additional, Siddique, Yasir Hasan, additional, Silva, Marilyn H., additional, Šimat, Vida, additional, Singh, Gyanendra, additional, Singh, Neha, additional, Singh, Shamsher, additional, Singh, Thakur Gurjeet, additional, Singh, Varinder, additional, Sirin, Seda, additional, Soares, Janaina Ribeiro Pereira, additional, Souza, Cleide dos Santos, additional, Souza, Nara, additional, Srivastava, Vikas, additional, Su, Kuan-Pin, additional, Sujatha, D., additional, Sukach, Volodymyr, additional, Sunitha, S., additional, Tabassum, Heena, additional, Tasca, Carla I., additional, Tasker, R. Andrew, additional, Tasleem, Ammar, additional, Tejada, S., additional, Tencomnao, Tewin, additional, Torres, Rosimere Oliveira, additional, Triniac, Hortense, additional, Tripathi, Swapnil, additional, Trotta, Teresa, additional, Ugbaja, Regina Ngozi, additional, Ugbaja, Victory Chukwudalu, additional, Ugwor, Emmanuel Ifeanyichukwu, additional, Urbano, Francisco J., additional, Uzal, Francisco A., additional, Valdez-Velazquez, L.L., additional, Vaz, Gustavo Richter, additional, Vázquez, Marta, additional, Vegas-Gomez, Laura, additional, Victor, Mauricio Moraes, additional, Villalba, Sofia, additional, Villano, Ines, additional, Vinadé, Lucia, additional, Vital, M.A.B.F., additional, Vittori, Daniela C., additional, Vivien, Denis, additional, Yachou, Yassine, additional, Yeste, Natalia, additional, Zaman, Khadiza, additional, Zavalza-Gálvez, D.I., additional, Zeb, Alam, additional, and Zhai, Kevin, additional

Published
2024
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7. Effect of the phospholipase A2 inhibitor Varespladib, and its synergism with crotalic antivenom, on the neuromuscular blockade induced by Crotalus durissus terrificus venom (with and without crotamine) in mouse neuromuscular preparations

Author

de Souza, Jocimar, Oliveira, Isadora C.F., Yoshida, Edson H., Cantuaria, Nathalia M., Cogo, José C., Torres-Bonilla, Kristian A., Hyslop, Stephen, Silva Junior, Nelson J., Floriano, Rafael S., Gutiérrez, José María, and Oshima-Franco, Yoko

Published
2022
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12. The Cloning and Characterization of a Three-Finger Toxin Homolog (NXH8) from the Coralsnake Micrurus corallinus That Interacts with Skeletal Muscle Nicotinic Acetylcholine Receptors.

Author

Roman-Ramos, Henrique, Prieto-da-Silva, Álvaro R. B., Dellê, Humberto, Floriano, Rafael S., Dias, Lourdes, Hyslop, Stephen, Schezaro-Ramos, Raphael, Servent, Denis, Mourier, Gilles, de Oliveira, Jéssica Lopes, Lemes, Douglas Edgard, Costa-Lotufo, Letícia V., Oliveira, Jane S., Menezes, Milene Cristina, Markus, Regina P., and Ho, Paulo Lee

Subjects
NICOTINIC acetylcholine receptors, VENOM, CHOLINERGIC receptors, SKELETAL muscle, MOLECULAR cloning, TOXINS, SEQUENCE analysis
Abstract

Coralsnakes (Micrurus spp.) are the only elapids found throughout the Americas. They are recognized for their highly neurotoxic venom, which is comprised of a wide variety of toxins, including the stable, low-mass toxins known as three-finger toxins (3FTx). Due to difficulties in venom extraction and availability, research on coralsnake venoms is still very limited when compared to that of other Elapidae snakes like cobras, kraits, and mambas. In this study, two previously described 3FTx from the venom of M. corallinus, NXH1 (3SOC1_MICCO), and NXH8 (3NO48_MICCO) were characterized. Using in silico, in vitro, and ex vivo experiments, the biological activities of these toxins were predicted and evaluated. The results showed that only NXH8 was capable of binding to skeletal muscle cells and modulating the activity of nAChRs in nerve–diaphragm preparations. These effects were antagonized by anti-rNXH8 or antielapidic sera. Sequence analysis revealed that the NXH1 toxin possesses eight cysteine residues and four disulfide bonds, while the NXH8 toxin has a primary structure similar to that of non-conventional 3FTx, with an additional disulfide bond on the first loop. These findings add more information related to the structural diversity present within the 3FTx class, while expanding our understanding of the mechanisms of the toxicity of this coralsnake venom and opening new perspectives for developing more effective therapeutic interventions. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Involvement of phospholipase A2 in the neuromuscular blockade caused by coralsnake (Micrurus spp.) venoms in mouse phrenic nerve-diaphragm preparations in vitro

Author

Couceiro, Fernanda Y.G.M., primary, Demico, Poliana J., additional, Dias, Samuel R., additional, Oliveira, Isabele N., additional, Pacagnelli, Francis L., additional, Silva, Elisangela O., additional, Sant’Anna, Sávio S., additional, Grego, Kathleen F., additional, Morais-Zani, Karen, additional, Torres-Bonilla, Kristian A., additional, Hyslop, Stephen, additional, and Floriano, Rafael S., additional

Published
2023
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22. Fipronil affects cockroach behavior and olfactory memory

Author

Rosa, Maria Eduarda, primary, Campos, Letícia, additional, Borges, Bruna Trindade, additional, Santos, Sara, additional, Barreto, Yuri Correia, additional, de Assis, Denis Reis, additional, Hyslop, Stephen, additional, de Souza, Velci Queiroz, additional, Vinadé, Lúcia, additional, and Dal Belo, Cháriston André, additional

Published
2023
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25. Functional [[beta].sub.2]-adrenoceptors in rat left atria: effect of foot-shock stress

Author

de Moura, Andre Luiz, Hyslop, Stephen, Grassi-Kassisse, Dora M., and Spadari, Regina C.

Subjects
Cell receptors -- Physiological aspects, Heart atrium -- Physiological aspects, Biological sciences
Abstract

Altered sensitivity to the chronotropic effect of catecholamines and a reduction in the [[beta].sub.1]/[[beta].sub.2]-adrenoceptor ratio have previously been reported in right atria of stressed rats, human failing heart, and aging. In this report, we investigated whether left atrial inotropism was affected by foot-shock stress. Male rats were submitted to 3 foot-shock sessions and the left atrial inotropic response, adenylyl cyclase activity, and [beta]-adrenoceptor expression were investigated. Left atria of stressed rats were supersensitive to isoprenaline when compared with control rats and this effect was abolished by ICI118,551, a selective [[beta].sub.2]-receptor antagonist. Schild plot slopes for the antagonism between CGP20712A (a selective [[beta].sub.1]-receptor antagonist) and isoprenaline differed from unity in atria of stressed but not control rats. Atrial sensitivity to norepinephrine, as well as basal and forskolin-or isoprenaline-stimulated adenylyl cyclase activities were not altered by stress. The effect of isoprenaline on adenylyl cyclase stimulation was partially blocked by ICI118,551 in atrial membranes of stressed rats. These findings indicate that foot-shock stress equally affects inotropism and chronotropism and that [[beta].sub.2]-adrenoceptor upregulation contributes to the enhanced inotropic response to isoprenaline. Key words: adenylate cyclase, CGP20712A, foot-shock stress, forskolin, inotropic response, isoprenaline, left atria, ICI118,551. La diminution de la sensibilite aux effets chronotropes des catecholamines et la reduction du ratio entre les recepteurs [[beta].sub.1] et [[beta].sub.2] adrenergiques ont deja ete rapportees pour l'oreillette droite de rats soumis a un stress, dans le creur insuffisant chez l'homme et avec le vieillissement. Dans cet article, nous avons tente de savoir si les proprietes inotropes de l'oreillette gauche sont affectees par le stress provoque par le choc au pied (<>). Nous avons soumis des rats males a trois seances de choc au pied et etudie la reaction inotrope de l'oreillette gauche, ainsi que l'activite de l'adenylate cyclase et l'expression des recepteurs [beta] adrenergiques. L'oreillette gauche des rats soumis a un stress etait plus sensible a l'isoprenaline que dans le groupe temoin, et cet effet etait aboli par le ICI118,551, un antagoniste selectif des recepteurs [[beta].sub.2] adrenergiques. Contrairement a chez les rats temoins, les pentes du diagramme de Schild de l'antagonisme entre le CGP20712A (un antagoniste selectif des recepteurs [[beta].sub.1] adrenergiques) et l'isoprenaline n'etaient pas egales a un chez les rats soumis a un stress. Le stress ne modifiait ni la sensibilite des oreillettes a la norepinephrine ni l'activite de l'adenylate cyclase de base ou stimulee par la forskoline ou l'isoprenaline. Dans les membranes auriculaires de rats soumis a un stress, le ICI118,551 permettait d'inhiber partiellement les effets de l'isoprenaline sur la stimulation de l'adenylate cyclase. Ces resultats montrent que le stress provoque par le choc au pied entraine des modifications inotropes et chronotropes equivalentes et que la regulation a la hausse des recepteurs [[beta].sub.2] adrenergiques contribue a l'accentuation des proprietes inotropes en reaction a l'isoprenaline. [Traduit par la Redaction] Mots-cles : adenylate cyclase, CGP20712A, stress provoque par le choc au pied, forskoline, reaction inotrope, isoprenaline, oreillette gauche, ICI118,551., Introduction [Beta.sub.1]-and [beta.sub.2]-adrenoceptors ([[beta].sub.1]-and [[beta].sub.2]-ARs) are expressed in rat and human heart, with [[beta].sub.1]-AR predominating over [[beta].sub.2]-AR in a ratio of about 4:1 (Juberg et al. 1985; Kaumann and Molenaar [...]

Published
2017
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28. Partial efficacy of a Brazilian coralsnake antivenom and varespladib in neutralizing distinct toxic effects induced by sublethal Micrurus dumerilii carinicauda envenoming in rats

Author

Silva-Carvalho, Rosimeire, primary, Gaspar, Matheus Z., additional, Quadros, Luiz H.B., additional, Lobo, Luís G.G., additional, Giuffrida, Rogério, additional, Santarém, Cecília L., additional, Silva, Elisangela O., additional, Gerez, Juliana R., additional, Silva, Nelson J., additional, Hyslop, Stephen, additional, Lomonte, Bruno, additional, and Floriano, Rafael S., additional

Published
2022
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31. Entomotoxicity of jaburetox: revisiting the neurotoxic mechanisms in insects

Author

Barreto, Yuri Correia, Rosa, Maria Eduarda, Zanatta, Ana Paula, Borges, Bruna Trindade, Hyslop, Stephen, Vinadé, Lúcia Helena, and Dal Belo, Cháriston André

Subjects
animal structures, neuromuscular blockade, Canavalia ensiformis, jack bean urease, parasitic diseases, fungi, entomotoxicity, voltage-gated sodium channel, plant ureases, Mini-Review, Behavioral alterations
Abstract

Ureases are metalloenzymes that hydrolyze urea to ammonia and carbamate. The main urease isoforms present in the seeds of Canavalia ensiformis (jack bean urease – JBU and canatoxin) exert a variety of biological activities. The insecticidal activity of JBU is mediated, at least in part, by jaburetox (Jbtx), a recombinant peptide derived from the JBU amino acid sequence. In this article, we review the neurotoxicity of Jbtx in insects. The insecticidal activity of Jbtx has been investigated in a variety of insect orders and species, including Blattodea (the cockroaches Blatella germânica, Nauphoeta cinerea, Periplaneta americana e Phoetalia pallida), Bruchidae (Callosobruchus maculatus – cowpea weevil), Diptera (Aedes aegypti – mosquito), Hemiptera (Dysdercus peruvianus – cotton stainer bug; Oncopeltus fasciatus – large milkweed bug, and the kissing bugs Rhodnius prolixus and Triatoma infestans), Lepidoptera (Spodoptera frugiperda – fall army worm) and Orthoptera (Locusta migratoria – locust). In N. cinerea, the injection of Jbtx induces marked alteration of locomotor and grooming behavior, whereas in T. infestans Jbtx causes leg paralysis, an extension of the proboscis and abnormal antennal movements. Electromyographical analysis showed that Jbtx causes complete neuromuscular blockade in P. pallida. The same treatment in N. cinerea and L. migratoria causes a decrease in the action potential firing rate. Jbtx forms membrane pore-channels compatible with cations in bilipid membranes. A study using B. germanica voltage-gated sodium (Nav1.1) channels that were heterologously expressed in Xenopus laevis oocytes correlated the entomotoxicity of Jbtx with the activation of these channels. Taken together, these findings demonstrate the potential of this peptide as a natural pesticide.

Published
2020

33. Action of Varespladib (LY-315920), a Phospholipase A2 Inhibitor, on the Enzymatic, Coagulant and Haemorrhagic Activities of Lachesis muta rhombeata (South-American Bushmaster) Venom

Author

Gutierres, Pamella G., primary, Pereira, Diego R., additional, Vieira, Nataly L., additional, Arantes, Lilian F., additional, Silva, Nelson J., additional, Torres-Bonilla, Kristian A., additional, Hyslop, Stephen, additional, Morais-Zani, Karen, additional, Nogueira, Rosa M. B., additional, Rowan, Edward G., additional, and Floriano, Rafael S., additional

Published
2022
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35. Evaluation of Protection by Caffeic Acid, Chlorogenic Acid, Quercetin and Tannic Acid against the In Vitro Neurotoxicity and In Vivo Lethality of Crotalus durissus terrificus (South American Rattlesnake) Venom

Author

Oliveira, Isadora, primary, Yoshida, Edson, additional, Dini, Murilo, additional, Paschoal, Ana, additional, Cogo, José, additional, da Cruz-Höfling, Maria, additional, Hyslop, Stephen, additional, and Oshima-Franco, Yoko, additional

Published
2021
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