1. Cardiopulmonary deconditioning and plasma volume loss are not sufficient to provoke orthostatic hypertension.
- Author
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Hoenemann JN, Moestl S, de Boni L, Hoffmann F, Arz M, Berger L, Pesta D, Heusser K, Mulder E, Lee SMC, Macias BR, Tank J, and Jordan J
- Subjects
- Humans, Male, Female, Adult, Middle Aged, Cardiovascular Deconditioning physiology, Hypovolemia physiopathology, Hypovolemia complications, Hemodynamics physiology, Oxygen Consumption physiology, Plasma Volume, Bed Rest adverse effects, Head-Down Tilt, Blood Pressure physiology, Hypertension physiopathology
- Abstract
Orthostatic hypertension, defined by an increase of systolic blood pressure (SBP) of ≥20 mmHg upon standing, harbors an increased cardiovascular risk. We pooled data from two rigorously conducted head-down tilt bedrest studies to test the hypothesis that cardiopulmonary deconditioning and hypovolemia predispose to orthostatic hypertension. With bedrest, peak VO
2 decreased by 6 ± 4 mlO2 /min/kg (p < 0.0001) and plasma volume by 367 ± 348 ml (p < 0.0001). Supine SBP increased from 127 ± 9 mmHg before to 133 ± 10 mmHg after bedrest (p < 0.0001). In participants with stable hemodynamics following head-up tilt, the incidence of orthostatic hypertension was 2 out of 67 participants before bedrest and 2 out of 57 after bedrest. We conclude that in most healthy persons, cardiovascular deconditioning and volume loss associated with long-term bedrest are not sufficient to cause orthostatic hypertension., (© 2024. The Author(s).)- Published
- 2024
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